{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T02:03:29Z","timestamp":1790906609598,"version":"4.1.0"},"reference-count":122,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,1,30]],"date-time":"2025-01-30T00:00:00Z","timestamp":1738195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000026","name":"National Institute on Drug Abuse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000026","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program, National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA050542"],"award-info":[{"award-number":["R01DA050542"]}],"id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program, National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA044582"],"award-info":[{"award-number":["R01DA044582"]}],"id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program, National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["F31DA059204"],"award-info":[{"award-number":["F31DA059204"]}],"id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program, National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["R01DA043252"],"award-info":[{"award-number":["R01DA043252"]}],"id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100030692","name":"Intramural Research Program, National Institute on Drug Abuse","doi-asserted-by":"publisher","award":["T32DA045734"],"award-info":[{"award-number":["T32DA045734"]}],"id":[{"id":"10.13039\/100030692","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bbi.2025.01.021","type":"journal-article","created":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T11:03:20Z","timestamp":1738407800000},"page":"3-23","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Neonatal exposure to morphine results in prolonged pain hypersensitivity during adolescence, driven by gut microbial dysbiosis and gut-brain axis-mediated inflammation"],"prefix":"10.1016","volume":"126","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1439-2028","authenticated-orcid":false,"given":"Danielle","family":"Antoine","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Tao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salma","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Praveen Kumar","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara G","family":"Marin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabita","family":"Roy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2025.01.021_b0005","article-title":"Brief Hydromorphone Exposure During Pregnancy Sufficient to Induce Maternal and Neonatal Microbial Dysbiosis","author":"Abu","year":"2021","journal-title":"Journal of Neuroimmune Pharmacology"},{"key":"10.1016\/j.bbi.2025.01.021_b0010","doi-asserted-by":"crossref","unstructured":"Y. F. Abu et al., \u201cOpioid-induced dysbiosis of maternal gut microbiota during gestation alters offspring gut microbiota and pain sensitivity,\u201d Gut Microbes, vol. 16, no. 1, 2024, doi: 10.1080\/19490976.2023.2292224.","DOI":"10.1080\/19490976.2023.2292224"},{"key":"10.1016\/j.bbi.2025.01.021_b0015","doi-asserted-by":"crossref","unstructured":"A. Agus, J. Planchais, and H. Sokol, \u201cGut Microbiota Regulation of Tryptophan Metabolism in Health and Disease,\u201d 2018. doi: 10.1016\/j.chom.2018.05.003.","DOI":"10.1016\/j.chom.2018.05.003"},{"key":"10.1016\/j.bbi.2025.01.021_b0020","doi-asserted-by":"crossref","unstructured":"R. Aiyer, N. Mehta, S. Gungor, and A. Gulati, \u201cA Systematic Review of NMDA Receptor Antagonists for Treatment of Neuropathic Pain in Clinical Practice,\u201d 2018. doi: 10.1097\/AJP.0000000000000547.","DOI":"10.1097\/AJP.0000000000000547"},{"key":"10.1016\/j.bbi.2025.01.021_b0025","doi-asserted-by":"crossref","unstructured":"M. M. Al-Mouqdad, T. M. Khalil, and S. S. Asfour, \u201cRetrospective study of short-term complications associated with early morphine use in intubated premature infants,\u201d Sci Rep, vol. 10, no. 1, 2020, doi: 10.1038\/s41598-020-67891-w.","DOI":"10.1038\/s41598-020-67891-w"},{"key":"10.1016\/j.bbi.2025.01.021_b0030","doi-asserted-by":"crossref","unstructured":"C. F. Anderson, M. Oukka, V. J. Kuchroo, and D. Sacks, \u201cCD4+CD25-Foxp3- Th1 cells are the source of IL-10-mediated immune suppression in chronic cutaneous leishmaniasis,\u201d Journal of Experimental Medicine, vol. 204, no. 2, 2007, doi: 10.1084\/jem.20061886.","DOI":"10.1084\/jem.20061886"},{"key":"10.1016\/j.bbi.2025.01.021_b0035","doi-asserted-by":"crossref","unstructured":"D. Antoine, P. K. Singh, J. Tao, and S. Roy, \u201cNeonatal Morphine Results in Long-Lasting Alterations to the Gut Microbiome in Adolescence and Adulthood in a Murine Model,\u201d Pharmaceutics, vol. 14, no. 9, 2022, doi: 10.3390\/pharmaceutics14091879.","DOI":"10.3390\/pharmaceutics14091879"},{"key":"10.1016\/j.bbi.2025.01.021_b0040","doi-asserted-by":"crossref","unstructured":"S. Attarian, L. C. Tran, A. Moore, G. Stanton, E. Meyer, and R. P. Moore, \u201cThe neurodevelopmental impact of neonatal morphine administration,\u201d 2014. doi: 10.3390\/brainsci4020321.","DOI":"10.3390\/brainsci4020321"},{"key":"10.1016\/j.bbi.2025.01.021_b0045","doi-asserted-by":"crossref","unstructured":"S. Banerjee et al., \u201cOpioid-induced gut microbial disruption and bile dysregulation leads to gut barrier compromise and sustained systemic inflammation,\u201d Mucosal Immunol, vol. 9, no. 6, 2016, doi: 10.1038\/mi.2016.9.","DOI":"10.1038\/mi.2016.9"},{"key":"10.1016\/j.bbi.2025.01.021_b0050","doi-asserted-by":"crossref","unstructured":"G. A. Barr and S. Wang, \u201cTolerance and withdrawal to chronic morphine treatment in the week-old rat pup,\u201d Eur J Pharmacol, vol. 215, no. 1, 1992, doi: 10.1016\/0014-2999(92)90605-4.","DOI":"10.1016\/0014-2999(92)90605-4"},{"key":"10.1016\/j.bbi.2025.01.021_b0055","doi-asserted-by":"crossref","unstructured":"M. Bersudsky et al., \u201cNon-redundant properties of IL-1\u03b1 and IL-1\u03b2 during acute colon inflammation in mice,\u201d Gut, vol. 63, no. 4, 2014, doi: 10.1136\/gutjnl-2012-303329.","DOI":"10.1136\/gutjnl-2012-303329"},{"key":"10.1016\/j.bbi.2025.01.021_b0060","doi-asserted-by":"crossref","unstructured":"S. C. Bokoliya, Y. Dorsett, H. Panier, and Y. Zhou, \u201cProcedures for Fecal Microbiota Transplantation in Murine Microbiome Studies,\u201d 2021. doi: 10.3389\/fcimb.2021.711055.","DOI":"10.3389\/fcimb.2021.711055"},{"key":"10.1016\/j.bbi.2025.01.021_b0065","doi-asserted-by":"crossref","unstructured":"E. Bolyen et al., \u201cReproducible, interactive, scalable and extensible microbiome data science using QIIME 2,\u201d 2019. doi: 10.1038\/s41587-019-0209-9.","DOI":"10.1038\/s41587-019-0209-9"},{"key":"10.1016\/j.bbi.2025.01.021_b0070","doi-asserted-by":"crossref","unstructured":"R. R. Bonomo et al., \u201cFecal transplantation and butyrate improve neuropathic pain, modify immune cell profile, and gene expression in the PNS of obese mice,\u201d Proc Natl Acad Sci U S A, vol. 117, no. 42, 2020, doi: 10.1073\/pnas.2006065117.","DOI":"10.1073\/pnas.2006065117"},{"key":"10.1016\/j.bbi.2025.01.021_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fpain.2021.691689","article-title":"Probiotic VSL#3 Treatment Reduces Colonic Permeability and Abdominal Pain Symptoms in Patients With Irritable Bowel Syndrome","volume":"2","author":"Boonma","year":"2021","journal-title":"Front. Pain Res."},{"key":"10.1016\/j.bbi.2025.01.021_b0080","doi-asserted-by":"crossref","unstructured":"K. N. Borrelli et al., \u201cSex differences in behavioral and brainstem transcriptomic neuroadaptations following neonatal opioid exposure in outbred mice,\u201d eNeuro, vol. 8, no. 5, 2021, doi: 10.1523\/ENEURO.0143-21.2021.","DOI":"10.1523\/ENEURO.0143-21.2021"},{"key":"10.1016\/j.bbi.2025.01.021_b0085","doi-asserted-by":"crossref","unstructured":"L. Bozzo, J. Puyal, and J. Y. Chatton, \u201cLactate Modulates the Activity of Primary Cortical Neurons through a Receptor-Mediated Pathway,\u201d PLoS One, vol. 8, no. 8, 2013, doi: 10.1371\/journal.pone.0071721.","DOI":"10.1371\/journal.pone.0071721"},{"key":"10.1016\/j.bbi.2025.01.021_b0090","doi-asserted-by":"crossref","unstructured":"M. W. Brand et al., \u201cThe altered schaedler flora: Continued applications of a defined murine microbial community,\u201d ILAR J, vol. 56, no. 2, 2015, doi: 10.1093\/ilar\/ilv012.","DOI":"10.1093\/ilar\/ilv012"},{"key":"10.1016\/j.bbi.2025.01.021_b0095","doi-asserted-by":"crossref","unstructured":"C. Kasai et al., \u201cComparison of the gut microbiota composition between obese and non-obese individuals in a Japanese population, as analyzed by terminal restriction fragment length polymorphism and next-generation sequencing,\u201d BMC Gastroenterol, vol. 15, no. 1, 2015, doi: 10.1186\/s12876-015-0330-2.","DOI":"10.1186\/s12876-015-0330-2"},{"key":"10.1016\/j.bbi.2025.01.021_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.foodres.2019.108939","article-title":"Ethanol extract of propolis prevents high-fat diet-induced insulin resistance and obesity in association with modulation of gut microbiota in mice","volume":"130","author":"Cai","year":"2020","journal-title":"Food Res. Int."},{"key":"10.1016\/j.bbi.2025.01.021_b0105","doi-asserted-by":"crossref","unstructured":"B. J. Callahan, P. J. McMurdie, M. J. Rosen, A. W. Han, A. J. A. Johnson, and S. P. Holmes, \u201cDADA2: High-resolution sample inference from Illumina amplicon data,\u201d Nat Methods, vol. 13, no. 7, 2016, doi: 10.1038\/nmeth.3869.","DOI":"10.1038\/nmeth.3869"},{"key":"10.1016\/j.bbi.2025.01.021_b0110","doi-asserted-by":"crossref","unstructured":"C. Chambers Ph.D. et al., \u201cThe prevalence of chronic pain in children and adolescents: a systematic review update and meta-analysis,\u201d Pain, Jul. 2024, doi: 10.1097\/j.pain.0000000000003267.","DOI":"10.1097\/j.pain.0000000000003267"},{"key":"10.1016\/j.bbi.2025.01.021_b0115","doi-asserted-by":"crossref","unstructured":"M. Chichlowski, N. Shah, J. L. Wampler, S. S. Wu, and J. A. Vanderhoof, \u201cBifidobacterium longum subspecies infantis (B. infantis) in pediatric nutrition: Current state of knowledge,\u201d 2020. doi: 10.3390\/nu12061581.","DOI":"10.3390\/nu12061581"},{"key":"10.1016\/j.bbi.2025.01.021_b0120","doi-asserted-by":"crossref","unstructured":"M. M. Craig and D. Bajic, \u201cLong-term behavioral effects in a rat model of prolonged postnatal morphine exposure,\u201d Behavioral Neuroscience, vol. 129, no. 5, 2015, doi: 10.1037\/bne0000081.","DOI":"10.1037\/bne0000081"},{"key":"10.1016\/j.bbi.2025.01.021_b0125","doi-asserted-by":"crossref","unstructured":"J. Crawford, S. Liu, R. Tao, P. Kramer, S. Bender, and F. Tao, \u201cThe ketogenic diet mitigates opioid-induced hyperalgesia by restoring short-chain fatty acids-producing bacteria in the gut,\u201d Pain, vol. 165, no. 9, 2024, doi: 10.1097\/j.pain.0000000000003212.","DOI":"10.1097\/j.pain.0000000000003212"},{"key":"10.1016\/j.bbi.2025.01.021_b0130","doi-asserted-by":"crossref","unstructured":"A. D\u2019Andrea et al., \u201cProduction of natural killer cell stimulatory factor (interleukin 12) by peripheral blood mononuclear cells,\u201d Journal of Experimental Medicine, vol. 176, no. 5, 1992, doi: 10.1084\/jem.176.5.1387.","DOI":"10.1084\/jem.176.5.1387"},{"key":"10.1016\/j.bbi.2025.01.021_b0135","doi-asserted-by":"crossref","unstructured":"D. Dowell, T. M. Haegerich, and R. Chou, \u201cCDC guideline for prescribing opioids for chronic pain-United States, 2016,\u201d JAMA - Journal of the American Medical Association, vol. 315, no. 15, 2016, doi: 10.1001\/jama.2016.1464.","DOI":"10.1001\/jama.2016.1464"},{"key":"10.1016\/j.bbi.2025.01.021_b0140","doi-asserted-by":"crossref","unstructured":"D. Dowell, K. R. Ragan, C. M. Jones, G. T. Baldwin, and R. Chou, \u201cCDC Clinical Practice Guideline for Prescribing Opioids for Pain - United States, 2022,\u201d MMWR Recomm Rep, vol. 71, no. 3, 2022, doi: 10.15585\/mmwr.rr7103a1.","DOI":"10.15585\/mmwr.rr7103a1"},{"key":"10.1016\/j.bbi.2025.01.021_b0145","doi-asserted-by":"crossref","unstructured":"L. D\u00fchrsen et al., \u201cEffects of repetitive exposure to pain and morphine treatment on the neonatal rat brain,\u201d Neonatology, vol. 103, no. 1, 2012, doi: 10.1159\/000341769.","DOI":"10.1159\/000341769"},{"key":"10.1016\/j.bbi.2025.01.021_b0150","doi-asserted-by":"crossref","unstructured":"S. H. Duncan, G. Holtrop, G. E. Lobley, A. G. Calder, C. S. Stewart, and H. J. Flint, \u201cContribution of acetate to butyrate formation by human faecal bacteria,\u201d British Journal of Nutrition, vol. 91, no. 6, 2004, doi: 10.1079\/bjn20041150.","DOI":"10.1079\/BJN20041150"},{"key":"10.1016\/j.bbi.2025.01.021_b0155","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2023.1202099","article-title":"Molecular and long-term behavioral consequences of neonatal opioid exposure and withdrawal in mice","volume":"17","author":"Dunn","year":"2023","journal-title":"Front Behav Neurosci"},{"key":"10.1016\/j.bbi.2025.01.021_b0160","doi-asserted-by":"crossref","unstructured":"X. Durrmeyer, L. Vutskits, K. J. S. Anand, and P. C. Rimensberger, \u201cUse of analgesic and sedative drugs in the NICU: Integrating clinical trials and laboratory data,\u201d 2010. doi: 10.1203\/PDR.0b013e3181c8eef3.","DOI":"10.1203\/PDR.0b013e3181c8eef3"},{"key":"10.1016\/j.bbi.2025.01.021_b0165","doi-asserted-by":"crossref","unstructured":"Z. Dworsky-Fried, B. J. Kerr, and A. M. W. Taylor, \u201cMicrobes, microglia, and pain,\u201d 2020. doi: 10.1016\/j.ynpai.2020.100045.","DOI":"10.1016\/j.ynpai.2020.100045"},{"key":"10.1016\/j.bbi.2025.01.021_b0170","doi-asserted-by":"crossref","unstructured":"F. S. Cheng, D. Pan, B. Chang, M. Jiang, and L. X. Sang, \u201cProbiotic mixture VSL#3: An overview of basic and clinical studies in chronic diseases,\u201d World J Clin Cases, vol. 8, no. 8, 2020, doi: 10.12998\/WJCC.V8.I8.1361.","DOI":"10.12998\/wjcc.v8.i8.1361"},{"key":"10.1016\/j.bbi.2025.01.021_b0175","doi-asserted-by":"crossref","unstructured":"S. A. Ferguson, W. L. Ward, M. G. Paule, R. W. Hall, and K. J. S. Anand, \u201cA pilot study of preemptive morphine analgesia in preterm neonates: Effects on head circumference, social behavior, and response latencies in early childhood,\u201d Neurotoxicol Teratol, vol. 34, no. 1, 2012, doi: 10.1016\/j.ntt.2011.10.008.","DOI":"10.1016\/j.ntt.2011.10.008"},{"key":"10.1016\/j.bbi.2025.01.021_b0180","doi-asserted-by":"crossref","unstructured":"R. B. Fillingim and T. J. Ness, \u201cSex-related hormonal influences on pain and analgesic responses,\u201d Neurosci Biobehav Rev, vol. 24, no. 4, 2000, doi: 10.1016\/S0149-7634(00)00017-8.","DOI":"10.1016\/S0149-7634(00)00017-8"},{"issue":"6","key":"10.1016\/j.bbi.2025.01.021_b0185","doi-asserted-by":"crossref","first-page":"e325","DOI":"10.1542\/neo.25-6-e325","article-title":"Developmental Outcomes after Opioid Exposure in the Fetus and Neonate","volume":"25","author":"Fong","year":"2024","journal-title":"NeoReviews"},{"key":"10.1016\/j.bbi.2025.01.021_b0190","unstructured":"M. Foote and Y. Zhou, \u201c14-3-3 proteins in neurological disorders,\u201d Int J Biochem Mol Biol, vol. 3, no. 2, 2012."},{"key":"10.1016\/j.bbi.2025.01.021_b0195","doi-asserted-by":"crossref","unstructured":"R. Franceschi, C. Rizzardi, E. Maines, A. Liguori, M. Soffiati, and G. Tornese, \u201cFailure to thrive in infant and toddlers: a practical flowchart-based approach in a hospital setting,\u201d Ital J Pediatr, vol. 47, no. 1, 2021, doi: 10.1186\/s13052-021-01017-4.","DOI":"10.1186\/s13052-021-01017-4"},{"key":"10.1016\/j.bbi.2025.01.021_b0200","doi-asserted-by":"crossref","unstructured":"S. Fukuda et al., \u201cBifidobacteria can protect from enteropathogenic infection through production of acetate,\u201d Nature, vol. 469, no. 7331, 2011, doi: 10.1038\/nature09646.","DOI":"10.1038\/nature09646"},{"key":"10.1016\/j.bbi.2025.01.021_b0205","unstructured":"J. Geitsen and J. Gerritsen, \u201cThe genus Romboutsia\u00a0: genomic and functional characterization of novel bacteria dedicated to life in the intestinal tract,\u201d 2015. [Online]. Available: https:\/\/api.semanticscholar.org\/CorpusID:90496170."},{"key":"10.1016\/j.bbi.2025.01.021_b0210","doi-asserted-by":"crossref","unstructured":"E. Giannetti et al., \u201cA Mixture of 3 Bifidobacteria Decreases Abdominal Pain and Improves the Quality of Life in Children with Irritable Bowel Syndrome,\u201d J Clin Gastroenterol, vol. 51, no. 1, 2017, doi: 10.1097\/MCG.0000000000000528.","DOI":"10.1097\/MCG.0000000000000528"},{"key":"10.1016\/j.bbi.2025.01.021_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijpharm.2020.120120","article-title":"The enhanced intestinal permeability of infant mice enables oral protein and macromolecular absorption without delivery technology","volume":"593","author":"Gleeson","year":"2021","journal-title":"Int J Pharm"},{"key":"10.1016\/j.bbi.2025.01.021_b0220","doi-asserted-by":"crossref","unstructured":"M. A. R. Gomez and M. Ibba, \u201cAminoacyl-tRNA synthetases,\u201d RNA, vol. 26, no. 8, 2020, doi: 10.1261\/RNA.071720.119.","DOI":"10.1261\/rna.071720.119"},{"key":"10.1016\/j.bbi.2025.01.021_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2021.108914","article-title":"Prenatal opioid administration induces shared alterations to the maternal and offspring gut microbiome: A preliminary analysis","volume":"227","author":"Grecco","year":"2021","journal-title":"Drug Alcohol Depend"},{"key":"10.1016\/j.bbi.2025.01.021_b0230","doi-asserted-by":"crossref","unstructured":"U. Grohmann et al., \u201cPositive Regulatory Role of IL-12 in Macrophages and Modulation by IFN-\u03b3,\u201d The Journal of Immunology, vol. 167, no. 1, 2001, doi: 10.4049\/jimmunol.167.1.221.","DOI":"10.4049\/jimmunol.167.1.221"},{"key":"10.1016\/j.bbi.2025.01.021_b0235","doi-asserted-by":"crossref","unstructured":"R. Guo, L. H. Chen, C. Xing, and T. Liu, \u201cPain regulation by gut microbiota: molecular mechanisms and therapeutic potential,\u201d 2019. doi: 10.1016\/j.bja.2019.07.026.","DOI":"10.1016\/j.bja.2019.07.026"},{"key":"10.1016\/j.bbi.2025.01.021_b0240","doi-asserted-by":"crossref","unstructured":"R. W. Hall and K. J. S. Anand, \u201cPain management in newborns,\u201d 2014. doi: 10.1016\/j.clp.2014.08.010.","DOI":"10.1016\/j.clp.2014.08.010"},{"key":"10.1016\/j.bbi.2025.01.021_b0245","doi-asserted-by":"crossref","unstructured":"S. Haq et al., \u201cDisruption of autophagy by increased 5-HT alters gut microbiota and enhances susceptibility to experimental colitis and Crohn\u2019s disease,\u201d Sci Adv, vol. 7, no. 45, 2021, doi: 10.1126\/sciadv.abi6442.","DOI":"10.1126\/sciadv.abi6442"},{"key":"10.1016\/j.bbi.2025.01.021_b0250","doi-asserted-by":"crossref","unstructured":"B. M. Henrick et al., \u201cColonization by B. infantis EVC001 modulates enteric inflammation in exclusively breastfed infants,\u201d Pediatr Res, vol. 86, no. 6, 2019, doi: 10.1038\/s41390-019-0533-2.","DOI":"10.1038\/s41390-019-0533-2"},{"key":"10.1016\/j.bbi.2025.01.021_b0255","doi-asserted-by":"crossref","unstructured":"A. Hiraku et al., \u201cEarly Probiotic Supplementation of Healthy Term Infants with Bifidobacterium longum subsp. infantis M-63 Is Safe and Leads to the Development of Bifidobacterium-Predominant Gut Microbiota: A Double-Blind, Placebo-Controlled Trial,\u201d Nutrients, vol. 15, no. 6, 2023, doi: 10.3390\/nu15061402.","DOI":"10.3390\/nu15061402"},{"key":"10.1016\/j.bbi.2025.01.021_b0260","doi-asserted-by":"crossref","unstructured":"J. Huang, W. Hong, M. Wan, and L. Zheng, \u201cMolecular mechanisms and therapeutic target of NETosis in diseases,\u201d 2022. doi: 10.1002\/mco2.162.","DOI":"10.1002\/mco2.162"},{"key":"10.1016\/j.bbi.2025.01.021_b0265","article-title":"Structure, Function and Diversity of the Healthy Human Microbiome The Human Microbiome Project Consortium HHS Public Access","volume":"486","author":"Human Microbiome Project Consortium","year":"2013","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2025.01.021_b0270","doi-asserted-by":"crossref","unstructured":"S. S. Iyer and G. Cheng, \u201cRole of interleukin 10 transcriptional regulation in inflammation and autoimmune disease,\u201d Crit Rev Immunol, vol. 32, no. 1, 2012, doi: 10.1615\/critrevimmunol.v32.i1.30.","DOI":"10.1615\/CritRevImmunol.v32.i1.30"},{"key":"10.1016\/j.bbi.2025.01.021_b0275","doi-asserted-by":"crossref","unstructured":"R. Jalodia et al., \u201cMorphine mediated neutrophil infiltration in intestinal tissue play essential role in histological damage and microbial dysbiosis,\u201d Gut Microbes, vol. 14, no. 1, 2022, doi: 10.1080\/19490976.2022.2143225.","DOI":"10.1080\/19490976.2022.2143225"},{"key":"10.1016\/j.bbi.2025.01.021_b0280","doi-asserted-by":"crossref","unstructured":"R. R. Ji, A. Nackley, Y. Huh, N. Terrando, and W. Maixner, \u201cNeuroinflammation and central sensitization in chronic and widespread pain,\u201d Anesthesiology, vol. 129, no. 2, 2018, doi: 10.1097\/ALN.0000000000002130.","DOI":"10.1097\/ALN.0000000000002130"},{"key":"10.1016\/j.bbi.2025.01.021_b0285","doi-asserted-by":"crossref","unstructured":"K. L. Jones and G. A. Barr, \u201cOntogeny of Morphine Withdrawal in the Rat,\u201d Behavioral Neuroscience, vol. 109, no. 6, 1995, doi: 10.1037\/0735-7044.109.6.1189.","DOI":"10.1037\/\/0735-7044.109.6.1189"},{"key":"10.1016\/j.bbi.2025.01.021_b0290","doi-asserted-by":"crossref","DOI":"10.1038\/srep30887","article-title":"Chronic Repression of mTOR Complex 2 Induces Changes in the Gut Microbiota of Diet-induced Obese Mice","volume":"6","author":"Jung","year":"2016","journal-title":"Sci Rep"},{"key":"10.1016\/j.bbi.2025.01.021_b0295","doi-asserted-by":"crossref","unstructured":"A. M. Kabat, N. Srinivasan, and K. J. Maloy, \u201cModulation of immune development and function by intestinal microbiota,\u201d 2014. doi: 10.1016\/j.it.2014.07.010.","DOI":"10.1016\/j.it.2014.07.010"},{"key":"10.1016\/j.bbi.2025.01.021_b0300","doi-asserted-by":"crossref","unstructured":"S. Kakodkar and E. A. Mutlu, \u201cDiet as a Therapeutic Option for Adult Inflammatory Bowel Disease,\u201d 2017. doi: 10.1016\/j.gtc.2017.08.016.","DOI":"10.1016\/j.gtc.2017.08.016"},{"key":"10.1016\/j.bbi.2025.01.021_b0305","doi-asserted-by":"crossref","unstructured":"A. E. Kalyuzhny, U. Arvidsson, W. Wu, and M. W. Wessendorf, \u201c\u03bc-Opioid and \u03b4-opioid receptors are expressed in brainstem antinociceptive circuits: Studies using immunocytochemistry and retrograde tract-tracing,\u201d Journal of Neuroscience, vol. 16, no. 20, 1996, doi: 10.1523\/jneurosci.16-20-06490.1996.","DOI":"10.1523\/JNEUROSCI.16-20-06490.1996"},{"key":"10.1016\/j.bbi.2025.01.021_b0310","doi-asserted-by":"crossref","unstructured":"A. Koh, F. De Vadder, P. Kovatcheva-Datchary, and F. B\u00e4ckhed, \u201cFrom dietary fiber to host physiology: Short-chain fatty acids as key bacterial metabolites,\u201d 2016. doi: 10.1016\/j.cell.2016.05.041.","DOI":"10.1016\/j.cell.2016.05.041"},{"key":"10.1016\/j.bbi.2025.01.021_b0315","doi-asserted-by":"crossref","unstructured":"G. Kroemer, C. Galassi, L. Zitvogel, and L. Galluzzi, \u201cImmunogenic cell stress and death,\u201d 2022. doi: 10.1038\/s41590-022-01132-2.","DOI":"10.1038\/s41590-022-01132-2"},{"key":"10.1016\/j.bbi.2025.01.021_b0320","doi-asserted-by":"crossref","unstructured":"Y. H. Kwon et al., \u201cModulation of Gut Microbiota Composition by Serotonin Signaling Influences Intestinal Immune Response and Susceptibility to Colitis,\u201d CMGH, vol. 7, no. 4, 2019, doi: 10.1016\/j.jcmgh.2019.01.004.","DOI":"10.1016\/j.jcmgh.2019.01.004"},{"key":"10.1016\/j.bbi.2025.01.021_b0325","doi-asserted-by":"crossref","unstructured":"M. Lee, S. Silverman, H. Hansen, V. Patel, and L. Manchikanti, \u201cA comprehensive review of opioid-induced hyperalgesia,\u201d 2011. doi: 10.36076\/ppj.2011\/14\/145.","DOI":"10.36076\/ppj.2011\/14\/145"},{"key":"10.1016\/j.bbi.2025.01.021_b0330","doi-asserted-by":"crossref","unstructured":"K. Lee, H. E. Vuong, D. J. Nusbaum, E. Y. Hsiao, C. J. Evans, and A. M. W. Taylor, \u201cThe gut microbiota mediates reward and sensory responses associated with regimen-selective morphine dependence,\u201d Neuropsychopharmacology, vol. 43, no. 13, 2018, doi: 10.1038\/s41386-018-0211-9.","DOI":"10.1038\/s41386-018-0211-9"},{"key":"10.1016\/j.bbi.2025.01.021_b0335","doi-asserted-by":"crossref","unstructured":"M. Lei, C. Guo, D. Wang, C. Zhang, and L. Hua, \u201cThe effect of probiotic Lactobacillus casei Shirota on knee osteoarthritis: A randomised double-blind, placebo-controlled clinical trial,\u201d Benef Microbes, vol. 8, no. 5, 2017, doi: 10.3920\/bm2016.0207.","DOI":"10.3920\/BM2016.0207"},{"issue":"8","key":"10.1016\/j.bbi.2025.01.021_b0340","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.1016\/j.cell.2024.03.014","article-title":"Gut microbiome and metabolome profiling in Framingham heart study reveals cholesterol-metabolizing bacteria","volume":"187","author":"Li","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2025.01.021_b0345","doi-asserted-by":"crossref","unstructured":"D. R. Loyd, M. A. Henry, and K. M. Hargreaves, \u201cSerotonergic neuromodulation of peripheral nociceptors,\u201d 2013. doi: 10.1016\/j.semcdb.2012.09.002.","DOI":"10.1016\/j.semcdb.2012.09.002"},{"key":"10.1016\/j.bbi.2025.01.021_b0350","doi-asserted-by":"crossref","unstructured":"E. Lucarini et al., \u201cVisceral sensitivity modulation by faecal microbiota transplantation: The active role of gut bacteria in pain persistence,\u201d Pain, vol. 163, no. 5, 2022, doi: 10.1097\/j.pain.0000000000002438.","DOI":"10.1097\/j.pain.0000000000002438"},{"key":"10.1016\/j.bbi.2025.01.021_b0355","doi-asserted-by":"crossref","unstructured":"M. Luzzati et al., \u201cMorphine exposure and neurodevelopmental outcome in infants born extremely preterm,\u201d Dev Med Child Neurol, vol. 65, no. 8, 2023, doi: 10.1111\/dmcn.15510.","DOI":"10.1111\/dmcn.15510"},{"key":"10.1016\/j.bbi.2025.01.021_b0360","doi-asserted-by":"crossref","unstructured":"J. B. Lynch et al., \u201cGut microbiota Turicibacter strains differentially modify bile acids and host lipids,\u201d Nat Commun, vol. 14, no. 1, 2023, doi: 10.1038\/s41467-023-39403-7.","DOI":"10.1038\/s41467-023-39403-7"},{"key":"10.1016\/j.bbi.2025.01.021_b0365","doi-asserted-by":"crossref","unstructured":"Z. Lyu et al., \u201cLong-Term Effects of Developmental Exposure to Oxycodone on Gut Microbiota and Relationship to Adult Behaviors and Metabolism,\u201d mSystems, vol. 7, no. 4, 2022, doi: 10.1128\/msystems.00336-22.","DOI":"10.1128\/msystems.00336-22"},{"key":"10.1016\/j.bbi.2025.01.021_b0370","doi-asserted-by":"crossref","unstructured":"M. B. Biggs et al., \u201cSystems-level metabolism of the altered Schaedler flora, a complete gut microbiota,\u201d ISME Journal, vol. 11, no. 2, 2017, doi: 10.1038\/ismej.2016.130.","DOI":"10.1038\/ismej.2016.130"},{"key":"10.1016\/j.bbi.2025.01.021_b0375","doi-asserted-by":"crossref","unstructured":"X. Ma et al., \u201cRegulation of IL-10 and IL-12 production and function in macrophages and dendritic cells,\u201d 2015. doi: 10.12688\/f1000research.7010.1.","DOI":"10.12688\/f1000research.7010.1"},{"key":"10.1016\/j.bbi.2025.01.021_b0380","doi-asserted-by":"crossref","unstructured":"A. Malik et al., \u201cIL-33 regulates the IgA-microbiota axis to restrain IL-1\u03b1 dependent colitis and tumorigenesis,\u201d The Journal of Immunology, vol. 198, no. 1_Supplement, 2017, doi: 10.4049\/jimmunol.198.supp.65.18.","DOI":"10.4049\/jimmunol.198.Supp.65.18"},{"key":"10.1016\/j.bbi.2025.01.021_b0385","doi-asserted-by":"crossref","unstructured":"G. M. Mawe and J. M. Hoffman, \u201cSerotonin signalling in the gut-functions, dysfunctions and therapeutic targets,\u201d 2013. doi: 10.1038\/nrgastro.2013.105.","DOI":"10.1038\/nrgastro.2013.177"},{"key":"10.1016\/j.bbi.2025.01.021_b0390","doi-asserted-by":"crossref","unstructured":"D. P. McKernan, P. Fitzgerald, T. G. Dinan, and J. F. Cryan, \u201cThe probiotic Bifidobacterium infantis 35624 displays visceral antinociceptive effects in the rat,\u201d Neurogastroenterology and Motility, vol. 22, no. 9, 2010, doi: 10.1111\/j.1365-2982.2010.01520.x.","DOI":"10.1111\/j.1365-2982.2010.01520.x"},{"key":"10.1016\/j.bbi.2025.01.021_b0395","doi-asserted-by":"crossref","unstructured":"A. Meimandipour et al., \u201cGastrointestinal tract morphological alteration by unpleasant physical treatment and modulating role of Lactobacillus in broilers,\u201d Br Poult Sci, vol. 51, no. 1, 2010, doi: 10.1080\/00071660903394455.","DOI":"10.1080\/00071660903394455"},{"key":"10.1016\/j.bbi.2025.01.021_b0400","doi-asserted-by":"crossref","unstructured":"J. Meng et al., \u201cMorphine Induces Bacterial Translocation in Mice by Compromising Intestinal Barrier Function in a TLR-Dependent Manner,\u201d PLoS One, vol. 8, no. 1, 2013, doi: 10.1371\/journal.pone.0054040.","DOI":"10.1371\/journal.pone.0054040"},{"key":"10.1016\/j.bbi.2025.01.021_b0405","doi-asserted-by":"crossref","unstructured":"T. Mokhtari, Y. Tu, and L. Hu, \u201cInvolvement of the hippocampus in chronic pain and depression,\u201d Brain Science Advances, vol. 5, no. 4, 2019, doi: 10.26599\/bsa.2019.9050025.","DOI":"10.26599\/BSA.2019.9050025"},{"key":"10.1016\/j.bbi.2025.01.021_b0410","doi-asserted-by":"crossref","unstructured":"A. Mukherjee, C. Lordan, R. P. Ross, and P. D. Cotter, \u201cGut microbes from the phylogenetically diverse genus Eubacterium and their various contributions to gut health,\u201d 2020. doi: 10.1080\/19490976.2020.1802866.","DOI":"10.1080\/19490976.2020.1802866"},{"key":"10.1016\/j.bbi.2025.01.021_b0415","doi-asserted-by":"crossref","unstructured":"G. J. Norman, K. Karelina, N. Zhang, J. C. Walton, J. S. Morris, and A. C. Devries, \u201cStress and IL-1\u0392 contribute to the development of depressive-like behavior following peripheral nerve injury,\u201d Mol Psychiatry, vol. 15, no. 4, 2010, doi: 10.1038\/mp.2009.91.","DOI":"10.1038\/mp.2009.91"},{"key":"10.1016\/j.bbi.2025.01.021_b0420","doi-asserted-by":"crossref","unstructured":"K. J. O\u2019Riordan et al., \u201cShort chain fatty acids: Microbial metabolites for gut-brain axis signalling,\u201d 2022. doi: 10.1016\/j.mce.2022.111572.","DOI":"10.1016\/j.mce.2022.111572"},{"key":"10.1016\/j.bbi.2025.01.021_b0425","doi-asserted-by":"crossref","unstructured":"K. E. Odegaard et al., \u201cCharacterization of the intergenerational impact of in utero and postnatal oxycodone exposure,\u201d Transl Psychiatry, vol. 10, no. 1, 2020, doi: 10.1038\/s41398-020-01012-z.","DOI":"10.1038\/s41398-020-01012-z"},{"key":"10.1016\/j.bbi.2025.01.021_b0430","doi-asserted-by":"crossref","unstructured":"M. Osikowicz, J. Mika, and B. Przewlocka, \u201cThe glutamatergic system as a target for neuropathic pain relief,\u201d Exp Physiol, vol. 98, no. 2, 2013, doi: 10.1113\/expphysiol.2012.069922.","DOI":"10.1113\/expphysiol.2012.069922"},{"key":"10.1016\/j.bbi.2025.01.021_b0435","doi-asserted-by":"crossref","unstructured":"M. H. Ossipov, G. O. Dussor, and F. Porreca, \u201cCentral modulation of pain,\u201d 2010. doi: 10.1172\/JCI43766.","DOI":"10.1172\/JCI43766"},{"key":"10.1016\/j.bbi.2025.01.021_b0440","doi-asserted-by":"crossref","unstructured":"M. H. Ossipov, K. Morimura, and F. Porreca, \u201cDescending pain modulation and chronification of pain,\u201d 2014. doi: 10.1097\/SPC.0000000000000055.","DOI":"10.1097\/SPC.0000000000000055"},{"key":"10.1016\/j.bbi.2025.01.021_b0445","doi-asserted-by":"crossref","unstructured":"C. J. Paller, C. M. Campbell, R. R. Edwards, and A. S. Dobs, \u201cSex-based differences in pain perception and treatment,\u201d 2009. doi: 10.1111\/j.1526-4637.2008.00558.x.","DOI":"10.1111\/j.1526-4637.2008.00558.x"},{"key":"10.1016\/j.bbi.2025.01.021_b0450","doi-asserted-by":"crossref","unstructured":"R. M. Patel, L. S. Myers, A. R. Kurundkar, A. Maheshwari, A. Nusrat, and P. W. Lin, \u201cProbiotic bacteria induce maturation of intestinal claudin 3 expression and barrier function,\u201d American Journal of Pathology, vol. 180, no. 2, 2012, doi: 10.1016\/j.ajpath.2011.10.025.","DOI":"10.1016\/j.ajpath.2011.10.025"},{"key":"10.1016\/j.bbi.2025.01.021_b0455","doi-asserted-by":"crossref","unstructured":"P. Pedersini, M. Savoldi, P. Berjano, and J. H. Villafa\u00f1e, \u201cA probiotic intervention on pain hypersensitivity and microbiota composition in patients with osteoarthritis pain: Study protocol for a randomized controlled trial,\u201d Arch Rheumatol, vol. 36, no. 2, 2021, doi: 10.46497\/ArchRheumatol.2021.7719.","DOI":"10.46497\/ArchRheumatol.2021.7719"},{"key":"10.1016\/j.bbi.2025.01.021_b0460","doi-asserted-by":"crossref","unstructured":"F. A. Pinho-Ribeiro, W. A. Verri, and I. M. Chiu, \u201cNociceptor Sensory Neuron\u2013Immune Interactions in Pain and Inflammation,\u201d 2017. doi: 10.1016\/j.it.2016.10.001.","DOI":"10.1016\/j.it.2016.10.001"},{"key":"10.1016\/j.bbi.2025.01.021_b0465","doi-asserted-by":"crossref","unstructured":"S. A. Robinson, A. D. Jones, J. K. Brynildsen, M. E. Ehrlich, and J. A. Blendy, \u201cNeurobehavioral effects of neonatal opioid exposure in mice: Influence of the OPRM1 SNP,\u201d Addiction Biology, vol. 25, no. 5, 2020, doi: 10.1111\/adb.12806.","DOI":"10.1111\/adb.12806"},{"key":"10.1016\/j.bbi.2025.01.021_b0470","doi-asserted-by":"crossref","unstructured":"N. Segata et al., \u201cMetagenomic biomarker discovery and explanation,\u201d Genome Biol, vol. 12, no. 6, 2011, doi: 10.1186\/gb-2011-12-6-r60.","DOI":"10.1186\/gb-2011-12-6-r60"},{"key":"10.1016\/j.bbi.2025.01.021_b0475","doi-asserted-by":"crossref","unstructured":"M. S. Shajib et al., \u201cCharacterization of Serotonin Signaling Components in Patients with Inflammatory Bowel Disease,\u201d J Can Assoc Gastroenterol, vol. 2, no. 3, 2019, doi: 10.1093\/jcag\/gwy039.","DOI":"10.1093\/jcag\/gwy039"},{"key":"10.1016\/j.bbi.2025.01.021_b0480","doi-asserted-by":"crossref","unstructured":"J. Shlisky et al., \u201cNutritional considerations for healthy aging and reduction in age-related chronic disease,\u201d 2017. doi: 10.3945\/an.116.013474.","DOI":"10.3945\/an.116.013474"},{"key":"10.1016\/j.bbi.2025.01.021_b0485","doi-asserted-by":"crossref","unstructured":"S. Sikandar and A. H. Dickenson, \u201cVisceral pain: The ins and outs, the ups and downs,\u201d 2012. doi: 10.1097\/SPC.0b013e32834f6ec9.","DOI":"10.1097\/SPC.0b013e32834f6ec9"},{"key":"10.1016\/j.bbi.2025.01.021_b0490","doi-asserted-by":"crossref","unstructured":"K. Sivieri, M. L. V. Morales, M. A. T. Adorno, I. K. Sakamoto, S. M. I. Saad, and E. A. Rossi, \u201cLactobacillus acidophilus CRL 1014 improved \u2018 gut health\u2019 in the SHIME\u00ae reactor,\u201d BMC Gastroenterol, vol. 13, no. 1, 2013, doi: 10.1186\/1471-230X-13-100.","DOI":"10.1186\/1471-230X-13-100"},{"key":"10.1016\/j.bbi.2025.01.021_b0495","doi-asserted-by":"crossref","unstructured":"C. Stolfi, C. Maresca, G. Monteleone, and F. Laudisi, \u201cImplication of Intestinal Barrier Dysfunction in Gut Dysbiosis and Diseases,\u201d 2022. doi: 10.3390\/biomedicines10020289.","DOI":"10.3390\/biomedicines10020289"},{"key":"10.1016\/j.bbi.2025.01.021_b0500","doi-asserted-by":"crossref","unstructured":"R. Temmermand, J. E. Barrett, and A. C. K. Fontana, \u201cGlutamatergic systems in neuropathic pain and emerging non-opioid therapies,\u201d 2022. doi: 10.1016\/j.phrs.2022.106492.","DOI":"10.1016\/j.phrs.2022.106492"},{"key":"10.1016\/j.bbi.2025.01.021_b0505","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2021.113787","article-title":"Fecal microbiota transplantation and antibiotic treatment attenuate naloxone-precipitated opioid withdrawal in morphine-dependent mice","volume":"343","author":"Thomaz","year":"2021","journal-title":"Exp Neurol"},{"key":"10.1016\/j.bbi.2025.01.021_b0510","doi-asserted-by":"crossref","unstructured":"G. Trinchieri, \u201cInterleukin-12: A proinflammatory cytokine with immunoregulatory functions that bridge innate resistance and antigen-specific adaptive immunity,\u201d 1995. doi: 10.1146\/annurev.iy.13.040195.001343.","DOI":"10.1146\/annurev.iy.13.040195.001343"},{"key":"10.1016\/j.bbi.2025.01.021_b0515","doi-asserted-by":"crossref","unstructured":"M. Tsuda, T. Masuda, J. Kitano, H. Shimoyama, H. Tozaki-Saitoh, and K. Inoue, \u201cIFN-\u03b3 receptor signaling mediates spinal microglia activation driving neuropathic pain,\u201d Proc Natl Acad Sci U S A, vol. 106, no. 19, 2009, doi: 10.1073\/pnas.0810420106.","DOI":"10.1073\/pnas.0810420106"},{"key":"10.1016\/j.bbi.2025.01.021_b0520","unstructured":"K. A. M. Ullrich, L. Lou Schulze, E. M. Paap, T. M. M\u00fcller, M. F. Neurath, and S. Zundler, \u201cImmunology of IL-12: An update on functional activities and implications for disease,\u201d 2020. doi: 10.17179\/excli2020-3104."},{"key":"10.1016\/j.bbi.2025.01.021_b0525","doi-asserted-by":"crossref","unstructured":"M. A. Underwood, J. B. German, C. B. Lebrilla, and D. A. Mills, \u201cBifidobacterium longum subspecies infantis: Champion colonizer of the infant gut,\u201d 2015. doi: 10.1038\/pr.2014.156.","DOI":"10.1038\/pr.2014.156"},{"key":"10.1016\/j.bbi.2025.01.021_b0530","doi-asserted-by":"crossref","unstructured":"A. G. Vanderwall and E. D. Milligan, \u201cCytokines in Pain: Harnessing Endogenous Anti-Inflammatory Signaling for Improved Pain Management,\u201d 2019. doi: 10.3389\/fimmu.2019.03009.","DOI":"10.3389\/fimmu.2019.03009"},{"key":"10.1016\/j.bbi.2025.01.021_b0535","doi-asserted-by":"crossref","unstructured":"W. A. Verri et al., \u201cNociceptive effect of subcutaneously injected interleukin-12 is mediated by endothelin (ET) acting on ETB receptors in rats,\u201d Journal of Pharmacology and Experimental Therapeutics, vol. 315, no. 2, 2005, doi: 10.1124\/jpet.105.089409.","DOI":"10.1124\/jpet.105.089409"},{"key":"10.1016\/j.bbi.2025.01.021_b0540","doi-asserted-by":"crossref","unstructured":"K. Vogel et al., \u201cBifidobacteria shape antimicrobial T-helper cell responses during infancy and adulthood,\u201d Nat Commun, vol. 14, no. 1, 2023, doi: 10.1038\/s41467-023-41630-x.","DOI":"10.1038\/s41467-023-41630-x"},{"key":"10.1016\/j.bbi.2025.01.021_b0545","doi-asserted-by":"crossref","unstructured":"F. Wang and S. Roy, \u201cGut Homeostasis, Microbial Dysbiosis, and Opioids,\u201d Toxicol Pathol, vol. 45, no. 1, 2017, doi: 10.1177\/0192623316679898.","DOI":"10.1177\/0192623316679898"},{"key":"10.1016\/j.bbi.2025.01.021_b0550","doi-asserted-by":"crossref","unstructured":"F. Wang, J. Meng, L. Zhang, T. Johnson, C. Chen, and S. Roy, \u201cMorphine induces changes in the gut microbiome and metabolome in a morphine dependence model,\u201d Sci Rep, vol. 8, no. 1, 2018, doi: 10.1038\/s41598-018-21915-8.","DOI":"10.1038\/s41598-018-21915-8"},{"key":"10.1016\/j.bbi.2025.01.021_b0555","doi-asserted-by":"crossref","unstructured":"J. H. Wang, \u201cThe molecular mechanism of oxidative phosphorylation.,\u201d Proc Natl Acad Sci U S A, vol. 58, no. 1, 1967, doi: 10.1073\/pnas.58.1.37.","DOI":"10.1073\/pnas.58.1.37"},{"key":"10.1016\/j.bbi.2025.01.021_b0560","doi-asserted-by":"crossref","unstructured":"J. Wei et al., \u201cSingle nucleus transcriptomics of ventral midbrain identifies glial activation associated with chronic opioid use disorder,\u201d Nat Commun, vol. 14, no. 1, 2023, doi: 10.1038\/s41467-023-41455-8.","DOI":"10.1038\/s41467-023-41455-8"},{"key":"10.1016\/j.bbi.2025.01.021_b0565","doi-asserted-by":"crossref","unstructured":"J. M. Yano et al., \u201cIndigenous bacteria from the gut microbiota regulate host serotonin biosynthesis,\u201d Cell, vol. 161, no. 2, 2015, doi: 10.1016\/j.cell.2015.02.047.","DOI":"10.1016\/j.cell.2015.02.047"},{"key":"10.1016\/j.bbi.2025.01.021_b0570","doi-asserted-by":"crossref","unstructured":"P. Yao and P. L. Fox, \u201cAminoacyl-tRNA synthetases in medicine and disease,\u201d 2013. doi: 10.1002\/emmm.201100626.","DOI":"10.1002\/emmm.201100626"},{"key":"10.1016\/j.bbi.2025.01.021_b0575","doi-asserted-by":"crossref","unstructured":"I. Yusufu et al., \u201cArticle a tryptophan-deficient diet induces gut microbiota dysbiosis and increases systemic inflammation in aged mice,\u201d Int J Mol Sci, vol. 22, no. 9, 2021, doi: 10.3390\/ijms22095005.","DOI":"10.3390\/ijms22095005"},{"key":"10.1016\/j.bbi.2025.01.021_b0580","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2007.12.043","article-title":"Neonatal morphine enhances nociception and decreases analgesia in young rats","volume":"1199","author":"Zhang","year":"2008","journal-title":"Brain Res"},{"key":"10.1016\/j.bbi.2025.01.021_b0585","doi-asserted-by":"crossref","unstructured":"L. Zhang et al., \u201cMorphine tolerance is attenuated in germfree mice and reversed by probiotics, implicating the role of gut microbiome,\u201d Proc Natl Acad Sci U S A, vol. 116, no. 27, 2019, doi: 10.1073\/pnas.1901182116.","DOI":"10.1073\/pnas.1901182116"},{"key":"10.1016\/j.bbi.2025.01.021_b0590","doi-asserted-by":"crossref","unstructured":"D. Zheng, T. Liwinski, and E. Elinav, \u201cInteraction between microbiota and immunity in health and disease,\u201d 2020. doi: 10.1038\/s41422-020-0332-7.","DOI":"10.1038\/s41422-020-0332-7"},{"key":"10.1016\/j.bbi.2025.01.021_b0595","doi-asserted-by":"crossref","unstructured":"X. Zhuang, Z. Tian, L. Li, Z. Zeng, M. Chen, and L. Xiong, \u201cFecal microbiota alterations associated with diarrhea-predominant irritable bowel syndrome,\u201d Front Microbiol, vol. 9, no. JUL, 2018, doi: 10.3389\/fmicb.2018.01600.","DOI":"10.3389\/fmicb.2018.01600"},{"key":"10.1016\/j.bbi.2025.01.021_b0600","doi-asserted-by":"crossref","unstructured":"X. Zhuang et al., \u201cContribution of pro-inflammatory cytokine signaling within midbrain periaqueductal gray to pain sensitivity in parkinson\u2019s disease Via GABAergic pathway,\u201d Front Neurol, vol. 7, no. JUL, 2016, doi: 10.3389\/fneur.2016.00104.","DOI":"10.3389\/fneur.2016.00104"},{"key":"10.1016\/j.bbi.2025.01.021_b0605","doi-asserted-by":"crossref","unstructured":"P. Zhuang et al., \u201cEicosapentaenoic and Docosahexaenoic Acids Differentially Alter Gut Microbiome and Reverse High-Fat Diet\u2013Induced Insulin Resistance,\u201d Mol Nutr Food Res, vol. 64, no. 10, 2020, doi: 10.1002\/mnfr.201900946.","DOI":"10.1002\/mnfr.201900946"},{"key":"10.1016\/j.bbi.2025.01.021_b0610","doi-asserted-by":"crossref","unstructured":"M. H. Zissen, G. Zhang, A. McKelvy, J. T. Propst, J. J. Kendig, and S. M. Sweitzer, \u201cTolerance, opioid-induced allodynia and withdrawal associated allodynia in infant and young rats,\u201d Neuroscience, vol. 144, no. 1, 2007, doi: 10.1016\/j.neuroscience.2006.08.078.","DOI":"10.1016\/j.neuroscience.2006.08.078"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125000327?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125000327?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T13:56:23Z","timestamp":1786024583000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159125000327"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":122,"alternative-id":["S0889159125000327"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2025.01.021","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Neonatal exposure to morphine results in prolonged pain hypersensitivity during adolescence, driven by gut microbial dysbiosis and gut-brain axis-mediated inflammation","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2025.01.021","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}