{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:35:39Z","timestamp":1763444139318,"version":"3.45.0"},"reference-count":60,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2025,8,1]],"date-time":"2025-08-01T00:00:00Z","timestamp":1754006400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003074","name":"Agencia Nacional de Promoci\u00f3n Cient\u00edfica y Tecnol\u00f3gica","doi-asserted-by":"publisher","award":["PICT 2019-03960"],"award-info":[{"award-number":["PICT 2019-03960"]}],"id":[{"id":"10.13039\/501100003074","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100010253","name":"Secretar\u00eda de Ciencia y T\u00e9cnica, Universidad de Buenos Aires","doi-asserted-by":"publisher","award":["20020190200110BA"],"award-info":[{"award-number":["20020190200110BA"]}],"id":[{"id":"10.13039\/501100010253","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009891","name":"International Society of Nephrology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009891","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002923","name":"Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002923","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005363","name":"Universidad de Buenos Aires","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005363","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007351","name":"University of Buenos Aires Secretariat of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007351","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2025,8]]},"DOI":"10.1016\/j.bbi.2025.04.019","type":"journal-article","created":{"date-parts":[[2025,4,14]],"date-time":"2025-04-14T11:05:30Z","timestamp":1744628730000},"page":"323-335","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Inducing elevated glucose levels in vitro: A model to simulate prediabetes (preDBT) states in primary cultures"],"prefix":"10.1016","volume":"128","author":[{"given":"Maria Pilar","family":"Canal","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Florencia","family":"Acutain","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karen Agustina","family":"Nini","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariana","family":"Munner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ornella","family":"Caruso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anna","family":"De Tomas-Liorio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adelina","family":"Badolati","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mar\u00eda Ver\u00f3nica","family":"Baez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2025.04.019_b0005","doi-asserted-by":"crossref","first-page":"312","DOI":"10.2174\/18715273113126660133","article-title":"A molecular bridge: connecting type 2 diabetes and Alzheimer\u2019s disease","volume":"13","author":"Ahmed","year":"2014","journal-title":"CNS & Neurol. Disord. - Drug Targets"},{"key":"10.1016\/j.bbi.2025.04.019_b0010","first-page":"S20","article-title":"2. Diagnosis and classification of diabetes: standards of care in diabetes\u20142024","volume":"47","author":"Committee","year":"2023","journal-title":"Diabetes Care"},{"key":"10.1016\/j.bbi.2025.04.019_b0015","doi-asserted-by":"crossref","first-page":"778","DOI":"10.3390\/biomedicines10040778","article-title":"Type 2 Diabetes mellitus as a risk factor for Alzheimer\u2019s disease: review and meta-analysis","volume":"10","author":"Athanasaki","year":"2022","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbi.2025.04.019_b0020","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1080\/13803390490514875","article-title":"The Relationship between Impaired Glucose Tolerance, Type 2 Diabetes, and Cognitive Function","volume":"26","author":"Awad","year":"2004","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.bbi.2025.04.019_b0025","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1007\/s11064-020-02964-w","article-title":"Aerobic glycolysis in the brain: warburg and crabtree contra pasteur","volume":"46","author":"Barros","year":"2021","journal-title":"Neurochem Res"},{"key":"10.1016\/j.bbi.2025.04.019_b0030","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1146\/annurev.med.46.1.223","article-title":"Advanced protein glycosylation in diabetes and aging","volume":"46","author":"Brownlee","year":"1995","journal-title":"Annu. Rev. Med."},{"key":"10.1016\/j.bbi.2025.04.019_b0035","first-page":"1693","article-title":"Elevated risk of type 2 diabetes for development of Alzheimer disease: a key role for oxidative stress in brain","volume":"1842","author":"Butterfield","year":"2014","journal-title":"BBA"},{"key":"10.1016\/j.bbi.2025.04.019_b0040","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.911331","article-title":"Impaired fasting glucose, oxidative distress, and cognitive impairment. Is this the starting point on DBT cognitive decline?","volume":"14","author":"Canal","year":"2022","journal-title":"Front Aging Neurosci."},{"key":"10.1016\/j.bbi.2025.04.019_b0045","doi-asserted-by":"crossref","first-page":"1055","DOI":"10.1007\/s11011-016-9849-3","article-title":"Methylglyoxal-induced neuroinflammatory response in in vitro astrocytic cultures and hippocampus of experimental animals","volume":"31","author":"Chu","year":"2016","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbi.2025.04.019_b0050","article-title":"Type 2 diabetes mellitus - Poster","volume":"2012","author":"Cooper","year":"2012","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbi.2025.04.019_b0055","doi-asserted-by":"crossref","first-page":"4409","DOI":"10.1210\/jc.2015-2012","article-title":"Cognitive performance at late adolescence and the risk for impaired fasting glucose among young adults","volume":"100","author":"Cukierman-Yaffe","year":"2015","journal-title":"J. Clin. Endocrinol. Metab."},{"key":"10.1016\/j.bbi.2025.04.019_b0060","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.3233\/JAD-230555","article-title":"Malignant brain aging: the formidable link between dysregulated signaling through mechanistic target of rapamycin pathways and Alzheimer\u2019s disease (Type 3 Diabetes)","volume":"95","author":"de la Monte","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbi.2025.04.019_b0065","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1038\/s41572-020-0165-1","article-title":"Diabetic ketoacidosis","volume":"6","author":"Dhatariya","year":"2020","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbi.2025.04.019_b0070","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/ane.12474","article-title":"Role of inflammation in sensory neuropathy in prediabetes or diabetes","volume":"133","author":"Duksal","year":"2016","journal-title":"Acta Neurol. Scand."},{"key":"10.1016\/j.bbi.2025.04.019_b0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1186\/s12902-018-0318-3","article-title":"Pre-diabetes and diabetes are independently associated with adverse cognitive test results: a cross-sectional, population-based study","volume":"18","author":"Dybjer","year":"2018","journal-title":"BMC Endocr. Disord."},{"key":"10.1016\/j.bbi.2025.04.019_b0080","doi-asserted-by":"crossref","DOI":"10.1111\/ijpo.13063","article-title":"Hyperglycemia: A determinant of cardiac autonomic dysfunction in youth with obesity across the spectrum of glycemic regulation","volume":"18","author":"El-Ayash","year":"2023","journal-title":"Pediatr. Obes."},{"key":"10.1016\/j.bbi.2025.04.019_b0085","doi-asserted-by":"crossref","first-page":"291","DOI":"10.2741\/4718","article-title":"Amelioration of prediabetes-induced changes of dendritic structural plasticity","volume":"24","author":"Fan","year":"2019","journal-title":"Front. Biosci. (Landmark Edition)"},{"key":"10.1016\/j.bbi.2025.04.019_b0090","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.3390\/biom13121778","article-title":"The association between Serum 25-hydroxyvitamin D3 levels and pro-inflammatory markers in new-onset type 2 diabetes mellitus and prediabetes","volume":"13","author":"Fenercioglu","year":"2023","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbi.2025.04.019_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1375908","article-title":"The role of neurovascular coupling dysfunction in cognitive decline of diabetes patients","volume":"18","author":"Feng","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbi.2025.04.019_b0100","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1002\/glia.20671","article-title":"Modulation of astrocytic metabolic phenotype by proinflammatory cytokines","volume":"56","author":"Gavillet","year":"2008","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2025.04.019_b0105","doi-asserted-by":"crossref","first-page":"602","DOI":"10.1111\/bcpt.14003","article-title":"A review on the new age methodologies for early detection of Alzheimer\u2019s and Parkinson\u2019s disease","volume":"134","author":"Ghosh","year":"2024","journal-title":"Basic Clin. Pharmacol. Toxicol."},{"key":"10.1016\/j.bbi.2025.04.019_b0110","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.2337\/db15-0596","article-title":"Hippocampal insulin resistance impairs spatial learning and synaptic plasticity","volume":"64","author":"Grillo","year":"2015","journal-title":"Diabetes"},{"key":"10.1016\/j.bbi.2025.04.019_b0115","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.mrgentox.2007.04.006","article-title":"High-throughput spectrophotometric assay of reactive oxygen species in serum","volume":"631","author":"Hayashi","year":"2007","journal-title":"Mutat Res"},{"key":"10.1016\/j.bbi.2025.04.019_b0120","article-title":"The variation and correlation of serum adiponectin, nesfatin-1, IL-6, and TNF-\u03b1 levels in prediabetes","volume":"13","author":"Huang","year":"2022","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbi.2025.04.019_b0125","doi-asserted-by":"crossref","first-page":"3575","DOI":"10.1007\/s10571-023-01366-0","article-title":"BMECs ameliorate high glucose-induced morphological aberrations and synaptic dysfunction via VEGF-mediated modulation of glucose uptake in cortical neurons","volume":"43","author":"Huang","year":"2023","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2025.04.019_b0130","unstructured":"International Diabetes Federation, 2024. Facts & figures [WWW Document]. International Diabetes Federation. URL https:\/\/idf.org\/about-diabetes\/diabetes-facts-figures\/ (accessed 12.13.24)."},{"key":"10.1016\/j.bbi.2025.04.019_b0135","doi-asserted-by":"crossref","first-page":"2406","DOI":"10.1038\/nprot.2006.356","article-title":"Culturing hippocampal neurons","volume":"1","author":"Kaech","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbi.2025.04.019_b0140","doi-asserted-by":"crossref","first-page":"2803","DOI":"10.1073\/pnas.79.9.2803","article-title":"Biosynthesis of rat insulins I and II: evidence for differential expression of the two genes","volume":"79","author":"Kakita","year":"1982","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2025.04.019_b0145","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1499458","article-title":"More than microglia: myeloid cells and biomarkers in neurodegeneration","volume":"18","author":"Kodosaki","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbi.2025.04.019_b0150","doi-asserted-by":"crossref","first-page":"11296","DOI":"10.1038\/s41598-022-15411-3","article-title":"Sesamin protects against neurotoxicity via inhibition of microglial activation under high glucose circumstances through modulating p38 and JNK signaling pathways","volume":"12","author":"Kongtawelert","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2025.04.019_b0155","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1007\/s12035-015-9667-3","article-title":"Hyperglycemia-induced oxidative-nitrosative stress induces inflammation and neurodegeneration via augmented tuberous sclerosis complex-2 (TSC-2) activation in neuronal cells","volume":"54","author":"Kumar","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2025.04.019_b0160","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12933-019-0824-2","article-title":"Circulating microRNA-21 is an early predictor of ROS-mediated damage in subjects with high risk of developing diabetes and in drug-na\u00efve T2D","volume":"18","author":"La Sala","year":"2019","journal-title":"Cardiovasc. Diabetol."},{"key":"10.1016\/j.bbi.2025.04.019_b0165","article-title":"Pathological hyperinsulinemia and hyperglycemia in the impaired glucose tolerance stage mediate endothelial dysfunction through miR-21, PTEN\/AKT\/eNOS, and MARK\/ET-1 pathways","volume":"12","author":"Liu","year":"2021","journal-title":"Front. Endocrinol."},{"key":"10.1016\/j.bbi.2025.04.019_b0170","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1590\/2359-3997000000238","article-title":"Serum fluorescent advanced glycation end (F-AGE) products in gestational diabetes patients","volume":"61","author":"Lobo J\u00fanior","year":"2017","journal-title":"Arch. Endocrinol. Metabol."},{"key":"10.1016\/j.bbi.2025.04.019_b0175","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1515\/revneuro-2013-0050","article-title":"Insulin resistance, neuroinflammation, and Alzheimer\u2019s disease","volume":"25","author":"Najem","year":"2014","journal-title":"Rev. Neurosci."},{"key":"10.1016\/j.bbi.2025.04.019_b0180","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.neurobiolaging.2018.03.023","article-title":"High glucose forces a positive feedback loop connecting ErbB4 expression and mTOR\/S6K pathway to aggravate the formation of tau hyperphosphorylation in differentiated SH-SY5Y cells","volume":"67","author":"Nie","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2025.04.019_b0185","first-page":"45","article-title":"Type 2 diabetes mellitus, oxidative stress and inflammation: examining the links","volume":"11","author":"Oguntibeju","year":"2019","journal-title":"Internat. J. Physiol. Pathophysiol. Pharmacol."},{"key":"10.1016\/j.bbi.2025.04.019_b0190","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2020.117914","article-title":"High glucose-induced ROS accumulation is a critical regulator of ERK1\/2-Akt-tuberin-mTOR signalling in RGC-5 cells","volume":"256","author":"Pal","year":"2020","journal-title":"Life Sci."},{"key":"10.1016\/j.bbi.2025.04.019_b0195","doi-asserted-by":"crossref","first-page":"264","DOI":"10.34172\/jcvtr.33272","article-title":"Correlation of inflammatory markers and NFATC4 gene expression among subjects with prediabetes","volume":"16","author":"Rajan","year":"2024","journal-title":"J. Cardiovasc. Thorac. Res."},{"key":"10.1016\/j.bbi.2025.04.019_b0200","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.arcmed.2017.03.018","article-title":"Vitamin E deficiency and oxidative status are associated with prediabetes in apparently healthy subjects","volume":"48","author":"Rodr\u00edguez-Ram\u00edrez","year":"2017","journal-title":"Arch. Med. Res."},{"key":"10.1016\/j.bbi.2025.04.019_b0205","article-title":"Hyperglycemia and advanced glycation end products disrupt BBB and promote occludin and claudin-5 protein secretion on extracellular microvesicles","volume":"10","author":"Rom","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2025.04.019_b0210","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1016\/j.bbadis.2008.12.003","article-title":"(Pre)diabetes, brain aging, and cognition","volume":"1792","author":"Roriz-Filho","year":"2009","journal-title":"Biochim. Biophys. Acta Mol. basis Dis."},{"key":"10.1016\/j.bbi.2025.04.019_b0215","doi-asserted-by":"crossref","first-page":"122","DOI":"10.2174\/0115665232261931231006103234","article-title":"Current updates on the role of microRNA in the diagnosis and treatment of neurodegenerative diseases","volume":"24","author":"Saleem","year":"2024","journal-title":"Curr Gene Ther"},{"key":"10.1016\/j.bbi.2025.04.019_b0220","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1007\/s11357-013-9613-0","article-title":"The impact of glucose disorders on cognition and brain volumes in the elderly: the Sydney Memory and Ageing Study","volume":"36","author":"Samaras","year":"2014","journal-title":"Age (Dordr.)"},{"key":"10.1016\/j.bbi.2025.04.019_b0225","doi-asserted-by":"crossref","first-page":"3663","DOI":"10.1007\/s10072-020-05008-x","article-title":"Diabetes and impaired fasting glucose in a population-based sample of individuals aged 75 + years: associations with cognition, major depressive disorder, functionality and quality of life\u2014the Piet\u00e0 study","volume":"42","author":"Santos","year":"2021","journal-title":"Neurol. Sci."},{"key":"10.1016\/j.bbi.2025.04.019_b0230","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/WAD.0b013e3181b03277","article-title":"Self-administered Gerocognitive Examination (SAGE)","volume":"24","author":"Scharre","year":"2010","journal-title":"Alzheimer Dis. Assoc. Disord."},{"key":"10.1016\/j.bbi.2025.04.019_b0235","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13195-017-0269-3","article-title":"Digitally translated Self-Administered Gerocognitive Examination (eSAGE): relationship with its validated paper version, neuropsychological evaluations, and clinical assessments","volume":"9","author":"Scharre","year":"2017","journal-title":"Alzheimer\u2019s Res. Therapy"},{"key":"10.1016\/j.bbi.2025.04.019_b0240","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1002\/gps.930010209","article-title":"The challenge of time: Clock-drawing and cognitive function in the elderly","volume":"1","author":"Shulman","year":"1986","journal-title":"Int. J. Geriatr. Psychiatry"},{"key":"10.1016\/j.bbi.2025.04.019_b0245","doi-asserted-by":"crossref","first-page":"616","DOI":"10.1080\/13813455.2023.2243651","article-title":"Role of oxidative stress in diabetes-induced complications and their management with antioxidants","volume":"130","author":"Singh","year":"2024","journal-title":"Arch Physiol Biochem"},{"key":"10.1016\/j.bbi.2025.04.019_b0250","doi-asserted-by":"crossref","first-page":"63","DOI":"10.3233\/JAD-2005-7107","article-title":"Impaired insulin and insulin-like growth factor expression and signaling mechanisms in Alzheimer\u2019s disease \u2013 is this type 3 diabetes?","volume":"7","author":"Steen","year":"2005","journal-title":"J. Alzheimer\u2019s Dis."},{"key":"10.1016\/j.bbi.2025.04.019_b0255","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70225","article-title":"The role of inflammation, oxidative stress, neuronal damage, and endothelial dysfunction in the neuropathology of cognitive complications in diabetes: a moderation and mediation analysis","volume":"15","author":"Sumbul-Sekerci","year":"2025","journal-title":"Brain Behav."},{"key":"10.1016\/j.bbi.2025.04.019_b0260","article-title":"Acute glucose fluctuation induces inflammation and neurons apoptosis in hippocampal tissues of diabetic rats","volume":"1\u20139","author":"Wang","year":"2019","journal-title":"J. Cell. Biochem."},{"year":"1997","series-title":"WAIS-III: administration and scoring manual: Wechsler Adult Intelligence Scale","author":"Wechsler","key":"10.1016\/j.bbi.2025.04.019_b0265"},{"key":"10.1016\/j.bbi.2025.04.019_b0270","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.cnur.2017.07.011","article-title":"Prediabetes: Beyond the Borderline","volume":"52","author":"Wilson","year":"2017","journal-title":"Nurs. Clin. North Am."},{"key":"10.1016\/j.bbi.2025.04.019_b0275","unstructured":"World Health Organization, 2024. Diabetes [WWW Document]. URL https:\/\/www.who.int\/health-topics\/diabetes (accessed 12.13.24)."},{"key":"10.1016\/j.bbi.2025.04.019_b0280","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1080\/13803395.2014.985189","article-title":"Fasting glucose and glucose tolerance as potential predictors of neurocognitive function among nondiabetic older adults","volume":"37","author":"Wright","year":"2015","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.bbi.2025.04.019_b0285","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1212\/01.WNL.0000134666.64593.BA","article-title":"Diabetes, impaired fasting glucose, and development of cognitive impairment in older women","volume":"63","author":"Yaffe","year":"2004","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2025.04.019_b0290","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s11357-013-9547-6","article-title":"Association of fasting serum insulin and fasting serum glucose levels with cognitive impairment in Chinese nonagenarians\/centenarians","volume":"36","author":"Yan-Ling","year":"2014","journal-title":"Age (Dordr.)"},{"key":"10.1016\/j.bbi.2025.04.019_b0295","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.clineuro.2018.01.031","article-title":"Inflammation role in sensory neuropathy in Chinese patients with diabetes\/prediabetes","volume":"166","author":"Zeng","year":"2018","journal-title":"Clin. Neurol. Neurosurg."},{"key":"10.1016\/j.bbi.2025.04.019_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.eclinm.2020.100649","article-title":"Proinflammatory cytokines predict the incidence of diabetic peripheral neuropathy over 5 years in Chinese type 2 diabetes patients: A prospective cohort study","volume":"31","author":"Zheng","year":"2021","journal-title":"EClinicalMedicine"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125001552?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125001552?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T05:32:25Z","timestamp":1763443945000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159125001552"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,8]]},"references-count":60,"alternative-id":["S0889159125001552"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2025.04.019","relation":{},"ISSN":["0889-1591"],"issn-type":[{"type":"print","value":"0889-1591"}],"subject":[],"published":{"date-parts":[[2025,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Inducing elevated glucose levels in vitro: A model to simulate prediabetes (preDBT) states in primary cultures","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2025.04.019","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}]}}