{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T10:43:14Z","timestamp":1791110594347,"version":"4.1.0"},"reference-count":81,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,10,1]],"date-time":"2025-10-01T00:00:00Z","timestamp":1759276800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,6,18]],"date-time":"2025-06-18T00:00:00Z","timestamp":1750204800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2025,10]]},"DOI":"10.1016\/j.bbi.2025.06.031","type":"journal-article","created":{"date-parts":[[2025,6,20]],"date-time":"2025-06-20T02:42:15Z","timestamp":1750387335000},"page":"388-398","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Sex-specific spatial memory deficits associated with region-specific neuroinflammatory changes in the dorsal hippocampus of rats exposed to neonatal repeated maternal separation"],"prefix":"10.1016","volume":"129","author":[{"given":"Hannah","family":"Illouz","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yannick","family":"Menger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oph\u00e9lie","family":"Schaack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Lelievre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierrick","family":"Poisbeau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2025.06.031_b0005","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.bbi.2024.08.010","article-title":"Transient impairment in microglial function causes sex-specific deficits in synaptic maturity and hippocampal function in mice exposed to early adversity","volume":"122","author":"Ahmed","year":"2024","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.bbi.2025.06.031_b0010","doi-asserted-by":"crossref","unstructured":"Aisa, B., Elizalde, N., Tordera, R., Lasheras, B., Del R\u00c3\u00ado, J., & Ram\u00c3\u00adrez, M.J. (2009) Effects of neonatal stress on markers of synaptic plasticity in the hippocampus: Implications for spatial memory. Hippocampus, 19, 1222\u20131231.","DOI":"10.1002\/hipo.20586"},{"key":"10.1016\/j.bbi.2025.06.031_b0015","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.psyneuen.2006.12.013","article-title":"Cognitive impairment associated to HPA axis hyperactivity after maternal separation in rats","volume":"32","author":"Aisa","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2025.06.031_b0020","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1016\/j.neuroscience.2022.04.023","article-title":"Effects of Early Life Adversities upon Memory Processes and Cognition in Rodent Models","volume":"497","author":"Alves","year":"2022","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2025.06.031_b0025","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbr.2009.06.005","article-title":"Object location memory in mice: Pharmacological validation and further evidence of hippocampal CA1 participation","volume":"204","author":"Assini","year":"2009","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2025.06.031_b0030","article-title":"Maternal separation leads to regional hippocampal microglial activation and alters the behavior in the adolescence in a sex-specific manner","volume":"9","author":"Bachiller","year":"2020","journal-title":"Brain Behav. Immun. - Health"},{"key":"10.1016\/j.bbi.2025.06.031_b0035","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.bbr.2017.02.006","article-title":"Behavioral effects in adolescence and early adulthood in two length models of maternal separation in male rats","volume":"324","author":"Banqueri","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2025.06.031_b0040","first-page":"114","article-title":"The impact of early life stress on the central oxytocin system and susceptibility for drug addiction: Applicability of oxytocin as a pharmacotherapy","volume":"110","author":"Baracz","year":"2020","journal-title":"Neurosci. Biobehav. Rev., IBNS 2017 - Contemporary Contributions to Basic and Translational Behavioral Neuroscience Research"},{"key":"10.1016\/j.bbi.2025.06.031_b0045","doi-asserted-by":"crossref","first-page":"10721","DOI":"10.1523\/JNEUROSCI.6413-10.2011","article-title":"When Is the Hippocampus Involved in Recognition Memory?","volume":"31","author":"Barker","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0050","doi-asserted-by":"crossref","first-page":"1684","DOI":"10.1038\/s42003-024-07396-8","article-title":"Sex-specific fear acquisition following early life stress is linked to amygdala and hippocampal purine and glutamate metabolism","volume":"7","author":"Bordes","year":"2024","journal-title":"Commun. Biol."},{"key":"10.1016\/j.bbi.2025.06.031_b0055","doi-asserted-by":"crossref","DOI":"10.1177\/2398212820979802","article-title":"The role of cytokines in modulating learning and memory and brain plasticity","volume":"4","author":"Bourgognon","year":"2020","journal-title":"Brain Neurosci. Adv."},{"key":"10.1016\/j.bbi.2025.06.031_b0060","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3389\/fphys.2015.00313","article-title":"Protective effects of intermittent hypoxia on brain and memory in a mouse model of apnea of prematurity","volume":"6","author":"Bouslama","year":"2015","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbi.2025.06.031_b0065","doi-asserted-by":"crossref","first-page":"14515","DOI":"10.1073\/pnas.0406344101","article-title":"Spatial memory, recognition memory, and the hippocampus","volume":"101","author":"Broadbent","year":"2004","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbi.2025.06.031_b0070","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3390\/jcm9020468","article-title":"Microglial Function in the Effects of Early-Life Stress on Brain and Behavioral Development","volume":"9","author":"Catale","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbi.2025.06.031_b0075","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1016\/0003-2697(87)90021-2","article-title":"Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction","volume":"162","author":"Chomczynski","year":"1987","journal-title":"Anal. Biochem."},{"key":"10.1016\/j.bbi.2025.06.031_b0080","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2025.06.031_b0085","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1038\/nature01868","article-title":"Trans-synaptic shift in anion gradient in spinal lamina I neurons as a mechanism of neuropathic pain","volume":"424","author":"Coull","year":"2003","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2025.06.031_b0090","doi-asserted-by":"crossref","first-page":"2738","DOI":"10.3390\/ijms20112738","article-title":"Early Life Stress and High FKBP5 Interact to Increase Anxiety-Like Symptoms through Altered AKT Signaling in the Dorsal Hippocampus","volume":"20","author":"Criado-Marrero","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2025.06.031_b0095","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.bbi.2022.09.014","article-title":"Early life stress impairs synaptic pruning in the developing hippocampus","volume":"107","author":"Dayananda","year":"2023","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.bbi.2025.06.031_b0100","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.nlm.2017.04.006","article-title":"Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice","volume":"141","author":"de Azeredo","year":"2017","journal-title":"Neurobiol. Learn. Mem."},{"key":"10.1016\/j.bbi.2025.06.031_b0105","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1159\/000486619","article-title":"Neonatal Stress Has a Long-Lasting Sex-Dependent Effect on Anxiety-Like Behavior and Neuronal Morphology in the Prefrontal Cortex and Hippocampus","volume":"40","author":"de Melo","year":"2018","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0110","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1152\/jn.01105.2012","article-title":"Postnatal maturation of GABAergic transmission in the rat basolateral amygdala","volume":"110","author":"Ehrlich","year":"2013","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbi.2025.06.031_b0115","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/0166-4328(88)90157-X","article-title":"A new one-trial test for neurobiological studies of memory in rats. 1: Behavioral data","volume":"31","author":"Ennaceur","year":"1988","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2025.06.031_b0120","doi-asserted-by":"crossref","first-page":"1252","DOI":"10.1007\/s11064-021-03263-8","article-title":"SAHA Improves Depressive Symptoms, Cognitive Impairment and Oxidative Stress: Rise of a New Antidepressant Class","volume":"46","author":"Ershadi","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbi.2025.06.031_b0125","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of Childhood Abuse and Household Dysfunction to Many of the Leading Causes of Death in Adults: The Adverse Childhood Experiences (ACE) Study","volume":"14","author":"Felitti","year":"1998","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.bbi.2025.06.031_b0130","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/nrn1701","article-title":"The development of nociceptive circuits","volume":"6","author":"Fitzgerald","year":"2005","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0135","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/j.bbi.2018.03.005","article-title":"Neuroinflammatory priming to stress is differentially regulated in male and female rats","volume":"70","author":"Fonken","year":"2018","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.bbi.2025.06.031_b0140","doi-asserted-by":"crossref","first-page":"1557","DOI":"10.1523\/JNEUROSCI.5180-07.2008","article-title":"Dissociated gender-specific effects of recurrent seizures on GABA signaling in CA1 pyramidal neurons: role of GABA(A) receptors","volume":"28","author":"Galanopoulou","year":"2008","journal-title":"J. Neurosci. Off. J. Soc. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0150","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbi.2020.12.010","article-title":"Overexpression of chloride importer NKCC1 contributes to the sensory-affective and sociability phenotype of rats following neonatal maternal separation","volume":"92","author":"Gazzo","year":"2021","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.bbi.2025.06.031_b0155","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2019.0283","article-title":"Does epigenetic \u2018memory\u2019 of early-life stress predispose to chronic pain in later life? A potential role for the stress regulator FKBP5","volume":"374","author":"G\u00e9ranton","year":"2019","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.bbi.2025.06.031_b0160","doi-asserted-by":"crossref","first-page":"4155","DOI":"10.1111\/ejn.16170","article-title":"Towards a central origin of nociceptive hypersensitivity in adult rats after a neonatal maternal separation","volume":"58","author":"Gier\u00e9","year":"2023","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0165","doi-asserted-by":"crossref","first-page":"7244","DOI":"10.1523\/JNEUROSCI.2973-18.2019","article-title":"Early Life Inflammation Increases CA1 Pyramidal Neuron Excitability in a Sex and Age Dependent Manner through a Chloride Homeostasis Disruption","volume":"39","author":"Gomez","year":"2019","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0170","doi-asserted-by":"crossref","DOI":"10.1098\/rstb.2021.0059","article-title":"Oxytocin and microglia in the development of social behaviour","volume":"377","author":"Gonzalez","year":"2022","journal-title":"Philos. Trans. R. Soc. B Biol. Sci."},{"key":"10.1016\/j.bbi.2025.06.031_b0175","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.psyneuen.2016.04.016","article-title":"Cognitive impairment effects of early life stress in adolescents can be predicted with early biomarkers: Impacts of sex, experience, and cytokines","volume":"71","author":"Grassi-Oliveira","year":"2016","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbi.2025.06.031_b0180","doi-asserted-by":"crossref","unstructured":"Herzog, J.I. & Schmahl, C. (2018) Adverse Childhood Experiences and the Consequences on Neurobiological, Psychosocial, and Somatic Conditions Across the Lifespan. Front. Psychiatry, 9.","DOI":"10.3389\/fpsyt.2018.00420"},{"key":"10.1016\/j.bbi.2025.06.031_b0185","doi-asserted-by":"crossref","unstructured":"Hoeijmakers, L., Lucassen, P.J., & Korosi, A. (2015) The interplay of early-life stress, nutrition, and immune activation programs adult hippocampal structure and function. Front. Mol. Neurosci., 7.","DOI":"10.3389\/fnmol.2014.00103"},{"key":"10.1016\/j.bbi.2025.06.031_b0190","doi-asserted-by":"crossref","first-page":"11878","DOI":"10.1038\/s41598-017-12183-z","article-title":"Bumetanide treatment during early development rescues maternal separation-induced susceptibility to stress","volume":"7","author":"Hu","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2025.06.031_b0195","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1016\/j.bbr.2010.08.038","article-title":"Maternal separation decreases adult hippocampal cell proliferation and impairs cognitive performance but has little effect on stress sensitivity and anxiety in adult Wistar rats","volume":"216","author":"Hulshof","year":"2011","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2025.06.031_b0200","first-page":"264","article-title":"Hypersensibilit\u00e9 \u00e0 la douleur et d\u00e9ficit d\u2019analg\u00e9sie induits par la s\u00e9paration maternelle n\u00e9onatale chez le rat\u00a0: identification de m\u00e9canismes \u00e9pig\u00e9n\u00e9tiques","volume":"36","author":"Illouz","year":"2023","journal-title":"Douleur Analg\u00e9sie"},{"key":"10.1016\/j.bbi.2025.06.031_b0205","article-title":"The key 1000 life-changing days","volume":"4","author":"Indrio","year":"2023","journal-title":"Glob. Pediatr."},{"key":"10.1016\/j.bbi.2025.06.031_b0210","doi-asserted-by":"crossref","unstructured":"Insausti, R. & Amaral, D.G. (2004) Hippocampal Formation. In The Human Nervous System. Elsevier, pp. 871\u2013914.","DOI":"10.1016\/B978-012547626-3\/50024-7"},{"key":"10.1016\/j.bbi.2025.06.031_b0215","doi-asserted-by":"crossref","first-page":"1952","DOI":"10.1111\/ejn.13294","article-title":"Peripheral and central alterations affecting spinal nociceptive processing and pain at adulthood in rats exposed to neonatal maternal deprivation","volume":"44","author":"Juif","year":"2016","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0220","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/S0306-4522(98)00324-8","article-title":"Morphine reversed formalin-induced CA1 pyramidal cell suppression via an effect on septohippocampal neural processing","volume":"89","author":"Khanna","year":"1999","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2025.06.031_b0225","doi-asserted-by":"crossref","unstructured":"Ladd, C.O., Huot, R.L., Thrivikraman, K.V., Nemeroff, C.B., Meaney, M.J., & Plotsky, P.M. (2000) Chapter 7 - Long-term behavioral and neuroendocrine adaptations to adverse early experience. In Mayer, E.A. & Saper, C.B. (eds), Progress in Brain Research, The Biological Basis for Mind Body Interactions. Elsevier, pp. 81\u2013103.","DOI":"10.1016\/S0079-6123(08)62132-9"},{"key":"10.1016\/j.bbi.2025.06.031_b0230","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1002\/jnr.10153","article-title":"Fibroblast growth factor-2 converts PACAP growth action on embryonic hindbrain precursors from stimulation to inhibition","volume":"67","author":"Lelievre","year":"2002","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2025.06.031_b0235","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.celrep.2016.03.013","article-title":"The Timing of the Excitatory-to-Inhibitory GABA Switch Is Regulated by the Oxytocin Receptor via KCC2","volume":"15","author":"Leonzino","year":"2016","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbi.2025.06.031_b0240","doi-asserted-by":"crossref","DOI":"10.1002\/jnr.25289","article-title":"Dorsoventral hippocampus distinctly modulates visceral sensitivity and anxiety behaviors in male IBS-like rats","volume":"102","author":"Lin","year":"2024","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbi.2025.06.031_b0245","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2023.109769","article-title":"Intranasal oxytocin alleviates comorbid depressive symptoms in neuropathic pain via elevating hippocampal BDNF production in both female and male mice","volume":"242","author":"Liu","year":"2024","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2025.06.031_b0250","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of Relative Gene Expression Data Using Real-Time Quantitative PCR and the 2\u2212\u0394\u0394CT Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbi.2025.06.031_b0255","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.jpain.2005.07.011","article-title":"Calibrated forceps: a sensitive and reliable tool for pain and analgesia studies","volume":"7","author":"Luis-Delgado","year":"2006","journal-title":"J. Pain"},{"key":"10.1016\/j.bbi.2025.06.031_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2022.104746","article-title":"Effects of early life stress on brain cytokines: A systematic review and meta-analysis of rodent studies","volume":"139","author":"Lumertz","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2025.06.031_b0265","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1002\/glia.23546","article-title":"Oxytocin receptor agonist reduces perinatal brain damage by targeting microglia","volume":"67","author":"Mairesse","year":"2019","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2025.06.031_b0270","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1016\/j.neuropharm.2007.11.019","article-title":"Functional interaction between 5-HT6 receptors and hypothalamic\u2013pituitary\u2013adrenal axis: Cognitive implications","volume":"54","author":"Marcos","year":"2008","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2025.06.031_b0275","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1146\/annurev.neuro.22.1.105","article-title":"Stress and hippocampal plasticity","volume":"22","author":"McEwen","year":"1999","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0280","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1111\/j.1749-6632.2001.tb05830.x","article-title":"Plasticity of the Hippocampus: Adaptation to Chronic Stress and Allostatic Load","volume":"933","author":"McEwen","year":"2001","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2025.06.031_b0285","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1016\/S0197-4580(02)00027-1","article-title":"Sex, stress and the hippocampus: allostasis, allostatic load and the aging process","volume":"23","author":"McEwen","year":"2002","journal-title":"Neurobiol. Aging, Brain Aging: Identifying the Brakes and Accelerators"},{"key":"10.1016\/j.bbi.2025.06.031_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114320","article-title":"Effects of sex and pro-inflammatory cytokines on context discrimination memory","volume":"442","author":"McNaughton","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2025.06.031_b0295","doi-asserted-by":"crossref","first-page":"2630","DOI":"10.1097\/j.pain.0000000000001375","article-title":"Pharmacological rescue of nociceptive hypersensitivity and oxytocin analgesia impairment in a rat model of neonatal maternal separation","volume":"159","author":"Melchior","year":"2018","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2025.06.031_b0300","doi-asserted-by":"crossref","first-page":"2216","DOI":"10.1111\/ejn.15153","article-title":"The burden of early life stress on the nociceptive system development and pain responses","volume":"55","author":"Melchior","year":"2022","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0305","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1016\/j.brainresbull.2015.07.004","article-title":"c-Fos expression correlates with performance on novel object and novel place recognition tests","volume":"117","author":"Mendez","year":"2015","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbi.2025.06.031_b0310","unstructured":"Moore, T., Arefadib, N., Deery, A., & West, S. (2017) The first Thousand Days: an evidence paper."},{"key":"10.1016\/j.bbi.2025.06.031_b0315","doi-asserted-by":"crossref","first-page":"1536","DOI":"10.1126\/science.aaf7003","article-title":"Ventral CA1 neurons store social memory","volume":"353","author":"Okuyama","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbi.2025.06.031_b0325","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1016\/0169-328X(93)90189-V","article-title":"Early, postnatal experience alters hypothalamic corticotropin-releasing factor (CRF) mRNA, median eminence CRF content and stress-induced release in adult rats","volume":"18","author":"Plotsky","year":"1993","journal-title":"Brain Res. Mol. Brain Res."},{"key":"10.1016\/j.bbi.2025.06.031_b0330","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/s41398-020-01027-6","article-title":"Environmental regulation of the chloride transporter KCC2: switching inflammation off to switch the GABA on?","volume":"10","author":"Pozzi","year":"2020","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2025.06.031_b0335","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-022-02265-6","article-title":"Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions","volume":"12","author":"Reemst","year":"2022","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2025.06.031_b0340","doi-asserted-by":"crossref","first-page":"42042","DOI":"10.1038\/srep42042","article-title":"Early-life stress impairs recognition memory and perturbs the functional maturation of prefrontal-hippocampal-perirhinal networks","volume":"7","author":"Reincke","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2025.06.031_b0345","doi-asserted-by":"crossref","first-page":"6098","DOI":"10.1016\/S0021-9258(19)39297-X","article-title":"The human oxytocin gene promoter is regulated by estrogens","volume":"265","author":"Richard","year":"1990","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbi.2025.06.031_b0350","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/16697","article-title":"The K+\/Cl- co-transporter KCC2 renders GABA hyperpolarizing during neuronal maturation","volume":"397","author":"Rivera","year":"1999","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2025.06.031_b0355","first-page":"39","article-title":"Maternal separation activates microglial cells and induces an inflammatory response in the hippocampus of male rat pups, independently of hypothalamic and peripheral cytokine levels. Brain. Behav. Immun","volume":"55","author":"Roque","year":"2016","journal-title":"Microglia, Physiology and Behavior"},{"key":"10.1016\/j.bbi.2025.06.031_b0360","doi-asserted-by":"crossref","first-page":"2721","DOI":"10.1038\/s41467-023-38373-0","article-title":"Neonatal immune challenge poses a sex-specific risk for epigenetic microglial reprogramming and behavioral impairment","volume":"14","author":"Schwabenland","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2025.06.031_b0365","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2022.11.005","article-title":"Early-life stress affects peripheral, blood-brain barrier, and brain responses to immune challenge in juvenile and adult rats","volume":"108","author":"Solarz","year":"2023","journal-title":"Brain. Behav. Immun."},{"key":"10.1016\/j.bbi.2025.06.031_b0370","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/npp.2010.13","article-title":"Interactions between age, stress and insulin on cognition: implications for Alzheimer\u2019s disease","volume":"35","author":"Solas","year":"2010","journal-title":"Neuropsychopharmacol. Off. Publ. Am. Coll. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2025.06.031_b0375","series-title":"Behavioral Neuroscience of Learning and Memory","first-page":"43","article-title":"Neural Activity Patterns Underlying Spatial Coding in the Hippocampus","author":"Sosa","year":"2018"},{"key":"10.1016\/j.bbi.2025.06.031_b0380","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1016\/j.neuroscience.2009.08.035","article-title":"Developmental up-regulation of the potassium\u2013chloride cotransporter type 2 in the rat lumbar spinal cord","volume":"164","author":"Stil","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2025.06.031_b0385","doi-asserted-by":"crossref","first-page":"1788","DOI":"10.1126\/science.1133212","article-title":"Maternal Oxytocin Triggers a Transient Inhibitory Switch in GABA Signaling in the Fetal Brain During Delivery","volume":"314","author":"Tyzio","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbi.2025.06.031_b0390","doi-asserted-by":"crossref","DOI":"10.1002\/0471142301.ns0831s69","article-title":"Examining object location and object recognition memory in mice","volume":"69","author":"Vogel-Ciernia","year":"2014","journal-title":"Curr. Protoc. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0395","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1097\/j.pain.0000000000002279","article-title":"Activation of the dorsal, but not the ventral, hippocampus relieves neuropathic pain in rodents","volume":"162","author":"Wei","year":"2021","journal-title":"PAIN"},{"key":"10.1016\/j.bbi.2025.06.031_b0400","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.3389\/fnins.2019.01082","article-title":"The Moderating Effects of Sex on Consequences of Childhood Maltreatment: From Clinical Studies to Animal Models","volume":"13","author":"White","year":"2019","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbi.2025.06.031_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108488","article-title":"Oxytocin mediates neuroprotection against hypoxic-ischemic injury in hippocampal CA1 neuron of neonatal rats","volume":"187","author":"Wu","year":"2021","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2025.06.031_b0410","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1016\/j.neuropharm.2018.04.002","article-title":"Dorsal CA1 interneurons contribute to acute stress-induced spatial memory deficits","volume":"135","author":"Yu","year":"2018","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2025.06.031_b0415","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/bs.vh.2021.11.002","article-title":"Oxytocin and vasopressin in the hippocampus","volume":"118","author":"Zagrean","year":"2022","journal-title":"Vitam. Horm."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088915912500248X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088915912500248X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,10,4]],"date-time":"2025-10-04T20:50:49Z","timestamp":1759611049000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088915912500248X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10]]},"references-count":81,"alternative-id":["S088915912500248X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2025.06.031","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex-specific spatial memory deficits associated with region-specific neuroinflammatory changes in the dorsal hippocampus of rats exposed to neonatal repeated maternal separation","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2025.06.031","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}]}}