{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,19]],"date-time":"2026-04-19T18:10:44Z","timestamp":1776622244171,"version":"3.51.2"},"reference-count":25,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,9,2]],"date-time":"2025-09-02T00:00:00Z","timestamp":1756771200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1186384"],"award-info":[{"award-number":["1186384"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["GNT118 7962"],"award-info":[{"award-number":["GNT118 7962"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["2938884"],"award-info":[{"award-number":["2938884"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100021856","name":"Ministero dell'Universit\u00e0 e della Ricerca","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021856","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["PE00000007"],"award-info":[{"award-number":["PE00000007"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000780","name":"European Commission","doi-asserted-by":"publisher","award":["2022E8T4FM"],"award-info":[{"award-number":["2022E8T4FM"]}],"id":[{"id":"10.13039\/501100000780","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bbi.2025.106099","type":"journal-article","created":{"date-parts":[[2025,9,3]],"date-time":"2025-09-03T06:51:34Z","timestamp":1756882294000},"page":"106099","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Comparing two anti-inflammatory reflexes: Splanchnic and hypothalamic\u2013pituitary\u2013adrenal"],"prefix":"10.1016","volume":"130","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6590-8720","authenticated-orcid":false,"given":"Michael","family":"McKinley","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Song T","family":"Yao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Davide","family":"Martelli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robin","family":"McAllen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5 Suppl 68","key":"10.1016\/j.bbi.2025.106099_b0005","article-title":"History of the development of corticosteroid therapy","volume":"29","author":"Benedek","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"issue":"2","key":"10.1016\/j.bbi.2025.106099_b0010","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/0008-8749(79)90129-1","article-title":"Immunoregulation mediated by the sympathetic nervous system","volume":"48","author":"Besedovsky","year":"1979","journal-title":"Cell. Immunol."},{"issue":"4764","key":"10.1016\/j.bbi.2025.106099_b0015","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1126\/science.3014662","article-title":"Immunoregulatory feedback between interleukin-1 and glucocorticoid hormones","volume":"233","author":"Besedovsky","year":"1986","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bbi.2025.106099_b0020","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1038\/ni0606-537","article-title":"Regulating inflammation by glucocorticoids","volume":"7","author":"Besedovsky","year":"2006","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2025.106099_b0025","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1159\/000542401","article-title":"A Glucocorticoid-Mediated Immunoregulatory Circuit Integrated at Brain Levels: our Early Studies and a present View","volume":"31","author":"Besedovsky","year":"2024","journal-title":"Neuroimmunomodulation"},{"issue":"6","key":"10.1016\/j.bbi.2025.106099_b0030","doi-asserted-by":"crossref","first-page":"1288","DOI":"10.1016\/S0091-6749(96)70197-5","article-title":"Interleukin-10 regulation in normal subjects and patients with asthma","volume":"97","author":"Borish","year":"1996","journal-title":"J. Allergy Clin. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2025.106099_b0035","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1172\/JCI107544","article-title":"The effect of in vivo hydrocortisone on subpopulations of human lymphocytes","volume":"53","author":"Fauci","year":"1974","journal-title":"J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbi.2025.106099_b0040","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1128\/CVI.13.2.281-288.2006","article-title":"General anesthesia delays the inflammatory response and increases survival for mice with endotoxic shock","volume":"13","author":"Fuentes","year":"2006","journal-title":"Clin. Vaccine Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2025.106099_b0045","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/S0165-5728(97)00262-2","article-title":"Glucocorticoids increase IL-10 expression in multiple sclerosis patients with acute relapse","volume":"85","author":"Gayo","year":"1998","journal-title":"J. Neuroimmunol."},{"issue":"3","key":"10.1016\/j.bbi.2025.106099_b0050","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.ygcen.2012.09.012","article-title":"The effect of isoflurane anaesthesia and vasectomy on circulating corticosterone and ACTH in BALB\/c mice","volume":"179","author":"Jacobsen","year":"2012","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.bbi.2025.106099_b0055","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.bbi.2018.06.005","article-title":"Vagal afferent activation suppresses systemic inflammation via the splanchnic anti-inflammatory pathway","volume":"73","author":"Komegae","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2025.106099_b0060","doi-asserted-by":"crossref","unstructured":"Kotanidou, A., et al., Urethan anesthesia protects rats against lethal endotoxemia and reduces TNF-alpha release. J Appl Physiol (1985), 1996. 81(5): p. 2305-11.","DOI":"10.1152\/jappl.1996.81.5.2304"},{"issue":"1","key":"10.1016\/j.bbi.2025.106099_b0065","doi-asserted-by":"crossref","first-page":"15009","DOI":"10.1038\/s41598-020-72008-4","article-title":"Sympathetic nerves control bacterial clearance","volume":"10","author":"Lankadeva","year":"2020","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bbi.2025.106099_b0070","doi-asserted-by":"crossref","first-page":"1677","DOI":"10.1113\/jphysiol.2013.268573","article-title":"Reflex control of inflammation by sympathetic nerves, not the vagus","volume":"592","author":"Martelli","year":"2014","journal-title":"J. Physiol."},{"issue":"9","key":"10.1016\/j.bbi.2025.106099_b0075","doi-asserted-by":"crossref","first-page":"R1085","DOI":"10.1152\/ajpregu.00259.2014","article-title":"Reflex control of inflammation by the splanchnic anti-inflammatory pathway is sustained and independent of anesthesia","volume":"307","author":"Martelli","year":"2014","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"3","key":"10.1016\/j.bbi.2025.106099_b0080","doi-asserted-by":"crossref","first-page":"R235","DOI":"10.1152\/ajpregu.00298.2018","article-title":"Anti-inflammatory reflex action of splanchnic sympathetic nerves is distributed across abdominal organs","volume":"316","author":"Martelli","year":"2019","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"20","key":"10.1016\/j.bbi.2025.106099_b0085","doi-asserted-by":"crossref","first-page":"4521","DOI":"10.1113\/JP283217","article-title":"Divergent splanchnic sympathetic efferent nerve pathways regulate interleukin-10 and tumour necrosis factor-alpha responses to endotoxaemia","volume":"600","author":"McKinley","year":"2022","journal-title":"J. Physiol."},{"issue":"6","key":"10.1016\/j.bbi.2025.106099_b0090","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1016\/S0889-1591(03)00084-9","article-title":"Contribution of the adrenal glands and splenic nerve to LPS-induced splenic cytokine production in the rat","volume":"17","author":"Meltzer","year":"2003","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bbi.2025.106099_b0095","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1365-2222.2004.01824.x","article-title":"Glucocorticoids up-regulate constitutive interleukin-10 production by human monocytes","volume":"34","author":"Mozo","year":"2004","journal-title":"Clin Exp Allergy"},{"key":"10.1016\/j.bbi.2025.106099_b0100","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbi.2021.07.019","article-title":"The endogenous inflammatory reflex inhibits the inflammatory response to different immune challenges in mice","volume":"97","author":"Occhinegro","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbi.2025.106099_b0105","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000531469","article-title":"Acute Inhibition of Inflammation Mediated by Sympathetic Nerves: the Inflammatory Reflex","volume":"30","author":"Occhinegro","year":"2023","journal-title":"Neuroimmunomodulation"},{"issue":"3","key":"10.1016\/j.bbi.2025.106099_b0110","first-page":"559","article-title":"The immune response in steroid deficient mice","volume":"24","author":"Streng","year":"1973","journal-title":"Immunology"},{"issue":"1","key":"10.1016\/j.bbi.2025.106099_b0115","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/S0039-6060(96)80217-0","article-title":"Corticosteroids increase blood interleukin-10 levels during cardiopulmonary bypass in men","volume":"119","author":"Tabardel","year":"1996","journal-title":"Surgery"},{"issue":"10","key":"10.1016\/j.bbi.2025.106099_b0120","first-page":"3604","article-title":"Hypercortisolemia increases plasma interleukin-10 concentrations during human endotoxemia\u2013a clinical research center study","volume":"81","author":"van der Poll","year":"1996","journal-title":"J. Clin. Endocrinol. Metab."},{"issue":"11","key":"10.1016\/j.bbi.2025.106099_b0125","doi-asserted-by":"crossref","first-page":"4255","DOI":"10.1182\/blood.V91.11.4255","article-title":"Differential regulation of interleukin-10 (IL-10) and IL-12 by glucocorticoids in vitro","volume":"91","author":"Visser","year":"1998","journal-title":"Blood"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125003344?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125003344?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,7]],"date-time":"2026-03-07T03:13:39Z","timestamp":1772853219000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159125003344"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":25,"alternative-id":["S0889159125003344"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2025.106099","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Comparing two anti-inflammatory reflexes: Splanchnic and hypothalamic\u2013pituitary\u2013adrenal","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2025.106099","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106099"}}