{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T16:30:24Z","timestamp":1789662624709,"version":"4.0.1"},"reference-count":110,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T00:00:00Z","timestamp":1763424000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004359","name":"Swedish Research Council","doi-asserted-by":"publisher","award":["2022-00564"],"award-info":[{"award-number":["2022-00564"]}],"id":[{"id":"10.13039\/501100004359","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011727","name":"Stockholm l\u00e4ns landsting","doi-asserted-by":"publisher","award":["972455"],"award-info":[{"award-number":["972455"]}],"id":[{"id":"10.13039\/501100011727","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007949","name":"Reumatikerf\u00f6rbundet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007949","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001447","name":"Rita Allen Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001447","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014034","name":"Foundation for Research in Rheumatology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014034","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004348","name":"Stockholm County Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004348","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bbi.2025.106185","type":"journal-article","created":{"date-parts":[[2025,11,20]],"date-time":"2025-11-20T14:55:13Z","timestamp":1763650513000},"page":"106185","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Searching for blood biomarkers and treatment targets in Women with fibromyalgia \u2013 Protein interaction patterns and anti-satellite glia cell IgG antibodies as promising candidates"],"prefix":"10.1016","volume":"132","author":[{"given":"Karolina af","family":"Ekenstam","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joana","family":"Menezes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jenny E.","family":"Jakobsson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helene","family":"Silverstein","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emerson","family":"Krock","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeanette","family":"Tour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katalin","family":"Sandor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Kuliszkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Matthew","family":"Hunt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Kultima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Macarena","family":"Tejos-Bravo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Camilla I.","family":"Svensson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Kosek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2025.106185_b0005","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbi.2018.09.018","article-title":"Brain glial activation in fibromyalgia - a multi-site positron emission tomography investigation","volume":"75","author":"Albrecht","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2025.106185_b0010","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2019.12.020","article-title":"Peripheral immune aberrations in fibromyalgia: a systematic review, meta-analysis and meta-regression","volume":"87","author":"Andr\u00e9s-Rodr\u00edguez","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"Pt 2","key":"10.1016\/j.bbi.2025.106185_b0015","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1242\/jcs.02814","article-title":"Dystroglycan: from biosynthesis to pathogenesis of human disease","volume":"119","author":"Barresi","year":"2006","journal-title":"J. Cell Sci."},{"issue":"19","key":"10.1016\/j.bbi.2025.106185_b0020","doi-asserted-by":"crossref","first-page":"15935","DOI":"10.1074\/jbc.M112.341156","article-title":"Matrix metalloproteinase-10 (MMP-10) interaction with tissue inhibitors of metalloproteinases TIMP-1 and TIMP-2: binding studies and crystal structure","volume":"287","author":"Batra","year":"2012","journal-title":"J. Biol. Chem."},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0025","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1096\/fasebj.4.2.2404817","article-title":"Structure and function of laminin: anatomy of a multidomain glycoprotein","volume":"4","author":"Beck","year":"1990","journal-title":"FASEB J."},{"key":"10.1016\/j.bbi.2025.106185_b0030","doi-asserted-by":"crossref","DOI":"10.1097\/j.pain.0000000000003527","article-title":"Early-life adversity as a predictor of fibromyalgia syndrome: the central role of perceived stress over endocrine stress indicators","author":"Beiner","year":"2025","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.bbi.2025.106185_b0035","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1097\/j.pain.0000000000002857","article-title":"Stress biomarkers in individuals with fibromyalgia syndrome: a systematic review with meta-analysis","volume":"164","author":"Beiner","year":"2023","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2025.106185_b0040","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1186\/1478-811X-7-13","article-title":"Crk and CrkL adaptor proteins: networks for physiological and pathological signaling","volume":"7","author":"Birge","year":"2009","journal-title":"Cell Commun. Signal"},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0045","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-3999(01)00296-3","article-title":"The validity of the Hospital anxiety and Depression Scale. an updated literature review","volume":"52","author":"Bjelland","year":"2002","journal-title":"J. Psychosom. Res."},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0050","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1093\/pm\/pnz255","article-title":"A Comparative Study of Fibromyalgia, Rheumatoid Arthritis, Spondyloarthritis, and Sj\u00f6gren's Syndrome; Impact of the Disease on Quality of Life, Psychological Adjustment, and use of Coping strategies","volume":"22","author":"Bucourt","year":"2021","journal-title":"Pain Med."},{"issue":"5","key":"10.1016\/j.bbi.2025.106185_b0055","first-page":"728","article-title":"The fibromyalgia impact questionnaire: development and validation","volume":"18","author":"Burckhardt","year":"1991","journal-title":"J. Rheumatol."},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0060","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh sleep Quality Index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbi.2025.106185_b0065","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2147\/JPR.S128508","article-title":"Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma","volume":"10","author":"B\u00e4ckryd","year":"2017","journal-title":"J. Pain Res."},{"issue":"5","key":"10.1016\/j.bbi.2025.106185_b0070","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1097\/j.pain.0000000000002451","article-title":"Hepatocyte growth factor, colony-stimulating factor 1, CD40, and 11 other inflammation-related proteins are associated with pain in diabetic neuropathy: exploration and replication serum data from the Pain in Neuropathy Study","volume":"163","author":"B\u00e4ckryd","year":"2022","journal-title":"Pain"},{"issue":"12","key":"10.1016\/j.bbi.2025.106185_b0075","doi-asserted-by":"crossref","first-page":"5877","DOI":"10.1073\/pnas.93.12.5877","article-title":"The recombinant proregion of transforming growth factor beta1 (latency-associated peptide) inhibits active transforming growth factor beta1 in transgenic mice","volume":"93","author":"B\u00f6ttinger","year":"1996","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2025.106185_b0080","doi-asserted-by":"crossref","unstructured":"Cai, W., Haddad, M., Haddad, R., Kesten, I., Hoffman, T., Laan, R., Westfall, S., Defaye, M., Abdullah, N. S., Wong, C., Brown, N., Tansley, S., Lister, K. C., Hooshmandi, M., Wang, F., Lorenzo, L.-E., Hovhannisyan, V., Ho-Tieng, D., Kumar, V., . . . Khoutorsky, A. The gut microbiota promotes pain in fibromyalgia. Neuron. doi:10.1016\/j.neuron.2025.03.032.","DOI":"10.1016\/j.neuron.2025.03.032"},{"issue":"6 Suppl 69","key":"10.1016\/j.bbi.2025.106185_b0085","first-page":"S118","article-title":"Chronic widespread pain and fibromyalgia: could there be some relationships with infections and vaccinations?","volume":"29","author":"Cassisi","year":"2011","journal-title":"Clin. Exp. Rheumatol."},{"issue":"17","key":"10.1016\/j.bbi.2025.106185_b0090","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2211631120","article-title":"Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia","volume":"120","author":"Caxaria","year":"2023","journal-title":"PNAS"},{"issue":"7480","key":"10.1016\/j.bbi.2025.106185_b0095","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1038\/nature12776","article-title":"Astrocytes mediate synapse elimination through MEGF10 and MERTK pathways","volume":"504","author":"Chung","year":"2013","journal-title":"Nature"},{"issue":"12","key":"10.1016\/j.bbi.2025.106185_b0100","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1002\/bies.201000063","article-title":"An immune paradox: how can the same chemokine axis regulate both immune tolerance and activation?: CCR6\/CCL20: a chemokine axis balancing immunological tolerance and inflammation in autoimmune disease","volume":"32","author":"Comerford","year":"2010","journal-title":"Bioessays"},{"key":"10.1016\/j.bbi.2025.106185_b0105","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.pharmthera.2017.08.008","article-title":"The role of the leukemia inhibitory factor receptor in neuroprotective signaling","volume":"183","author":"Davis","year":"2018","journal-title":"Pharmacol. Ther."},{"issue":"3","key":"10.1016\/j.bbi.2025.106185_b0110","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S1074-7613(00)80615-9","article-title":"A novel lysosome-associated membrane glycoprotein, DC-LAMP, induced upon DC maturation, is transiently expressed in MHC class II compartment","volume":"9","author":"de Saint-Vis","year":"1998","journal-title":"Immunity"},{"issue":"3","key":"10.1016\/j.bbi.2025.106185_b0115","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1007\/s10072-021-05806-x","article-title":"The puzzle of fibromyalgia between central sensitization syndrome and small fiber neuropathy: a narrative review on neurophysiological and morphological evidence","volume":"43","author":"de Tommaso","year":"2022","journal-title":"Neurol. Sci."},{"issue":"6","key":"10.1016\/j.bbi.2025.106185_b0120","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1016\/j.cell.2020.05.003","article-title":"The Physiology, Pathology, and potential Therapeutic applications of the TREM2 Signaling Pathway","volume":"181","author":"Deczkowska","year":"2020","journal-title":"Cell"},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0125","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/j.1600-065X.2009.00782.x","article-title":"Molecular mechanism and function of CD40\/CD40L engagement in the immune system","volume":"229","author":"Elgueta","year":"2009","journal-title":"Immunol. Rev."},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0130","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.ejpain.2005.02.001","article-title":"Decreased muscle blood flow in fibromyalgia patients during standardised muscle exercise: a contrast media enhanced colour Doppler study","volume":"10","author":"Elvin","year":"2006","journal-title":"Eur. J. Pain"},{"issue":"22","key":"10.1016\/j.bbi.2025.106185_b0135","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1080\/09638280601055782","article-title":"Assessment of fatigue in patients with fibromyalgia and chronic widespread pain. Reliability and validity of the swedish version of the MFI-20","volume":"29","author":"Ericsson","year":"2007","journal-title":"Disabil. Rehabil."},{"issue":"4","key":"10.1016\/j.bbi.2025.106185_b0140","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1002\/ana.25565","article-title":"Reduction of skin innervation is associated with a severe fibromyalgia phenotype","volume":"86","author":"Evdokimov","year":"2019","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0145","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.semarthrit.2017.01.005","article-title":"Frequency of concomitant fibromyalgia in rheumatic diseases: Monocentric study of 691 patients","volume":"47","author":"Fan","year":"2017","journal-title":"Semin. Arthritis Rheum."},{"key":"10.1016\/j.bbi.2025.106185_b0150","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbi.2023.09.003","article-title":"Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior cingulate cortex","volume":"114","author":"Fanton","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0155","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1097\/j.pain.0000000000002309","article-title":"The translocator protein gene is associated with endogenous pain modulation and the balance between glutamate and \u03b3-aminobutyric acid in fibromyalgia and healthy subjects: a multimodal neuroimaging study","volume":"163","author":"Fanton","year":"2022","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.bbi.2025.106185_b0160","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1016\/j.bbabio.2016.02.004","article-title":"The ATPase Inhibitory factor 1 (IF1): a master regulator of energy metabolism and of cell survival","volume":"1857","author":"Garc\u00eda-Berm\u00fadez","year":"2016","journal-title":"Biochim. Biophys. Acta"},{"issue":"12","key":"10.1016\/j.bbi.2025.106185_b0165","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1089\/jir.2022.0132","article-title":"IFN-\u03b3 and TGF-\u03b2, crucial players in Immune responses: a Tribute to Howard Young","volume":"42","author":"Gauthier","year":"2022","journal-title":"J. Interferon Cytokine Res."},{"issue":"8","key":"10.1016\/j.bbi.2025.106185_b0170","doi-asserted-by":"crossref","first-page":"1205","DOI":"10.1002\/j.1532-2149.2013.00284.x","article-title":"Decreased muscle concentrations of ATP and PCR in the quadriceps muscle of fibromyalgia patients\u2013a 31P-MRS study","volume":"17","author":"Gerdle","year":"2013","journal-title":"Eur. J. Pain"},{"issue":"6","key":"10.1016\/j.bbi.2025.106185_b0175","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1080\/14789450.2020.1797499","article-title":"Proteomic studies of common chronic pain conditions - a systematic review and associated network analyses","volume":"17","author":"Gerdle","year":"2020","journal-title":"Expert Rev. Proteomics"},{"issue":"11","key":"10.1016\/j.bbi.2025.106185_b0180","doi-asserted-by":"crossref","DOI":"10.3390\/jcm9113527","article-title":"Evidence of Mitochondrial Dysfunction in Fibromyalgia: Deviating Muscle Energy Metabolism Detected using Microdialysis and magnetic Resonance","volume":"9","author":"Gerdle","year":"2020","journal-title":"J. Clin. Med."},{"issue":"13","key":"10.1016\/j.bbi.2025.106185_b0185","doi-asserted-by":"crossref","DOI":"10.1172\/JCI144201","article-title":"Passive transfer of fibromyalgia symptoms from patients to mice","volume":"131","author":"Goebel","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2025.106185_b0190","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jprot.2018.04.004","article-title":"Proteome-based systems biology in chronic pain","volume":"190","author":"Gomez-Varela","year":"2019","journal-title":"J. Proteomics"},{"key":"10.1016\/j.bbi.2025.106185_b0195","doi-asserted-by":"crossref","first-page":"721","DOI":"10.3389\/fimmu.2020.00721","article-title":"The CD83 Molecule - an Important Immune Checkpoint","volume":"11","author":"Grosche","year":"2020","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0200","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1038\/s41592-019-0650-1","article-title":"CLIJ: GPU-accelerated image processing for everyone","volume":"17","author":"Haase","year":"2020","journal-title":"Nat. Methods"},{"issue":"3","key":"10.1016\/j.bbi.2025.106185_b0205","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1006\/mcne.2002.1181","article-title":"The calsyntenins\u2013a family of postsynaptic membrane proteins with distinct neuronal expression patterns","volume":"21","author":"Hintsch","year":"2002","journal-title":"Mol. Cell. Neurosci."},{"issue":"3","key":"10.1016\/j.bbi.2025.106185_b0210","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/j.1440-1827.2010.02634.x","article-title":"Downregulation of the B-cell receptor signaling component CD79b in plasma cell myeloma: a possible post transcriptional regulation","volume":"61","author":"Huang","year":"2011","journal-title":"Pathol. Int."},{"key":"10.1016\/j.bbi.2025.106185_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2022.109497","article-title":"DRGquant: a new modular AI-based pipeline for 3D analysis of the DRG","volume":"371","author":"Hunt","year":"2022","journal-title":"J. Neurosci. Methods"},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0220","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1515\/sjpain-2018-0340","article-title":"Detection of systemic inflammation in severely impaired chronic pain patients and effects of a multimodal pain rehabilitation program","volume":"19","author":"Hysing","year":"2019","journal-title":"Scand J Pain"},{"issue":"4","key":"10.1016\/j.bbi.2025.106185_b0225","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1038\/cmi.2017.107","article-title":"The unique structural and functional features of CXCL12","volume":"15","author":"Janssens","year":"2018","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbi.2025.106185_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.cyto.2021.155684","article-title":"Unravelling the broader complexity of IL-6 involvement in health and disease","volume":"148","author":"Jenkins","year":"2021","journal-title":"Cytokine"},{"issue":"1\u20132","key":"10.1016\/j.bbi.2025.106185_b0235","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1016\/j.pain.2004.12.032","article-title":"Widespread pain in fibromyalgia is related to a deficit of endogenous pain inhibition","volume":"114","author":"Julien","year":"2005","journal-title":"Pain"},{"issue":"1\u20132","key":"10.1016\/j.bbi.2025.106185_b0240","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.jneuroim.2011.10.013","article-title":"Evidence of central inflammation in fibromyalgia-increased cerebrospinal fluid interleukin-8 levels","volume":"242","author":"Kadetoff","year":"2012","journal-title":"J. Neuroimmunol."},{"issue":"12","key":"10.1016\/j.bbi.2025.106185_b0245","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1016\/j.tins.2022.10.007","article-title":"Interferon \u03b3: a master cytokine in microglia-mediated neural network dysfunction and neurodegeneration","volume":"45","author":"Kann","year":"2022","journal-title":"Trends Neurosci."},{"issue":"3\u20134","key":"10.1016\/j.bbi.2025.106185_b0250","first-page":"69","article-title":"CD40\/CD40 ligand interactions in immune responses and pulmonary immunity","volume":"73","author":"Kawabe","year":"2011","journal-title":"Nagoya J. Med. Sci."},{"issue":"13","key":"10.1016\/j.bbi.2025.106185_b0255","doi-asserted-by":"crossref","DOI":"10.3390\/cancers15133466","article-title":"Regulation and Functions of \u03b16-Integrin (CD49f) in Cancer Biology","volume":"15","author":"Khademi","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"43","key":"10.1016\/j.bbi.2025.106185_b0260","doi-asserted-by":"crossref","first-page":"11138","DOI":"10.1523\/JNEUROSCI.1238-16.2016","article-title":"TREM2\/DAP12 Signal Elicits Proinflammatory Response in Microglia and Exacerbates Neuropathic Pain","volume":"36","author":"Kobayashi","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2025.106185_b0265","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.npep.2016.11.002","article-title":"The neuropeptide galanin modulates natural killer cell function","volume":"64","author":"Koller","year":"2017","journal-title":"Neuropeptides"},{"issue":"6","key":"10.1016\/j.bbi.2025.106185_b0270","doi-asserted-by":"crossref","first-page":"866","DOI":"10.4103\/1673-5374.158332","article-title":"Matrilin-2, an extracellular adaptor protein, is needed for the regeneration of muscle, nerve and other tissues","volume":"10","author":"Korpos","year":"2015","journal-title":"Neural Regen. Res."},{"issue":"12","key":"10.1016\/j.bbi.2025.106185_b0275","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1007\/s00262-018-2165-5","article-title":"Cystatin F as a regulator of immune cell cytotoxicity","volume":"67","author":"Kos","year":"2018","journal-title":"Cancer Immunol. Immunother."},{"issue":"3","key":"10.1016\/j.bbi.2025.106185_b0280","doi-asserted-by":"crossref","first-page":"117","DOI":"10.2340\/165019771993117124","article-title":"A comparison of pressure pain thresholds in different tissues and body regions. long-term reliability of pressure algometry in healthy volunteers","volume":"25","author":"Kosek","year":"1993","journal-title":"Scand. J. Rehabil. Med."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0285","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0304-3959(96)03295-2","article-title":"Modulatory influence on somatosensory perception from vibration and heterotopic noxious conditioning stimulation (HNCS) in fibromyalgia patients and healthy subjects","volume":"70","author":"Kosek","year":"1997","journal-title":"Pain"},{"issue":"8","key":"10.1016\/j.bbi.2025.106185_b0290","doi-asserted-by":"crossref","first-page":"1828","DOI":"10.1097\/j.pain.0000000000002881","article-title":"Fibromyalgia patients with elevated levels of anti-satellite glia cell immunoglobulin G antibodies present with more severe symptoms","volume":"164","author":"Krock","year":"2023","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.bbi.2025.106185_b0295","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1038\/s41590-023-01510-4","article-title":"CD4(+) T cell memory","volume":"24","author":"K\u00fcnzli","year":"2023","journal-title":"Nat. Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0300","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.pharmthera.2007.05.009","article-title":"The galanin peptide family: receptor pharmacology, pleiotropic biological actions, and implications in health and disease","volume":"115","author":"Lang","year":"2007","journal-title":"Pharmacol. Ther."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0305","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pain.2010.06.021","article-title":"Dysfunction of endogenous pain inhibition during exercise with painful muscles in patients with shoulder myalgia and fibromyalgia","volume":"151","author":"Lannersten","year":"2010","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0310","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/ar3306","article-title":"The role of the central nervous system in the generation and maintenance of chronic pain in rheumatoid arthritis, osteoarthritis and fibromyalgia","volume":"13","author":"Lee","year":"2011","journal-title":"Arthritis Res. Ther."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0315","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.cyto.2014.10.014","article-title":"Interferon gamma in autoimmunity: a complicated player on a complex stage","volume":"74","author":"Lees","year":"2015","journal-title":"Cytokine"},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0320","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/BOR.0000000000000464","article-title":"The complexities of fibromyalgia and its comorbidities","volume":"30","author":"Lichtenstein","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0325","doi-asserted-by":"crossref","first-page":"26","DOI":"10.3892\/br.2020.1402","article-title":"Functions of CD169 positive macrophages in human diseases (Review)","volume":"14","author":"Liu","year":"2021","journal-title":"Biomed Rep"},{"key":"10.1016\/j.bbi.2025.106185_b0330","doi-asserted-by":"crossref","DOI":"10.1155\/2012\/925135","article-title":"CD4+T cells: differentiation and functions","volume":"2012","author":"Luckheeram","year":"2012","journal-title":"Clin. Dev. Immunol."},{"issue":"8","key":"10.1016\/j.bbi.2025.106185_b0335","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1111\/j.1526-4637.2011.01168.x","article-title":"An evolutionary stress-response hypothesis for chronic widespread pain (fibromyalgia syndrome)","volume":"12","author":"Lyon","year":"2011","journal-title":"Pain Med."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0340","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/nprot.2006.461","article-title":"Production of dissociated sensory neuron cultures and considerations for their use in studying neuronal function and plasticity","volume":"2","author":"Malin","year":"2007","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbi.2025.106185_b0345","article-title":"Fibromyalgia: when Distress Becomes (Un)sympathetic Pain","volume":"2012","author":"Martinez-Lavin","year":"2012","journal-title":"Pain Res. Treat."},{"key":"10.1016\/j.bbi.2025.106185_b0350","article-title":"The ITGB6 gene: its role in experimental and clinical biology","volume":"5","author":"Meecham","year":"2020","journal-title":"Gene X"},{"issue":"7","key":"10.1016\/j.bbi.2025.106185_b0355","doi-asserted-by":"crossref","DOI":"10.1016\/j.autrev.2021.102846","article-title":"CCR6-CCL20 axis as a therapeutic target for autoimmune diseases","volume":"20","author":"Meitei","year":"2021","journal-title":"Autoimmun. Rev."},{"issue":"6","key":"10.1016\/j.bbi.2025.106185_b0360","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1007\/s10787-013-0177-5","article-title":"The multiple faces of CCL13 in immunity and inflammation","volume":"21","author":"Mendez-Enriquez","year":"2013","journal-title":"Inflammopharmacology"},{"issue":"11","key":"10.1016\/j.bbi.2025.106185_b0365","doi-asserted-by":"crossref","first-page":"2589","DOI":"10.1097\/j.pain.0000000000001640","article-title":"Altered microbiome composition in individuals with fibromyalgia","volume":"160","author":"Minerbi","year":"2019","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2025.106185_b0370","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.intimp.2017.08.012","article-title":"CCL28 chemokine: an anchoring point bridging innate and adaptive immunity","volume":"51","author":"Mohan","year":"2017","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbi.2025.106185_b0375","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1146\/annurev.iy.07.040189.001045","article-title":"TH1 and TH2 cells: different patterns of lymphokine secretion lead to different functional properties","volume":"7","author":"Mosmann","year":"1989","journal-title":"Annu. Rev. Immunol."},{"key":"10.1016\/j.bbi.2025.106185_b0380","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1007\/978-3-030-36667-4_3","article-title":"CCL4 Signaling in the Tumor Microenvironment","volume":"1231","author":"Mukaida","year":"2020","journal-title":"Adv. Exp. Med. Biol."},{"key":"10.1016\/j.bbi.2025.106185_b0385","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2020.577391","article-title":"Elevated inflammatory proteins in cerebrospinal fluid from patients with painful knee osteoarthritis are associated with reduced symptom severity","volume":"349","author":"Palada","year":"2020","journal-title":"J. Neuroimmunol."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0390","doi-asserted-by":"crossref","first-page":"91","DOI":"10.2741\/4089","article-title":"Scratching the surface: signaling and routing dynamics of the CSF3 receptor","volume":"18","author":"Palande","year":"2013","journal-title":"Front Biosci (landmark Ed)"},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0395","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/nyas.14111","article-title":"Influence of the regulatory peptide galanin on cytokine expression in human monocytes","volume":"1455","author":"Ramspacher","year":"2019","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0400","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/S1357-4310(99)01635-4","article-title":"Eotaxin and eosinophil recruitment: implications for human disease","volume":"6","author":"Rankin","year":"2000","journal-title":"Mol. Med. Today"},{"issue":"5","key":"10.1016\/j.bbi.2025.106185_b0405","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1084\/jem.20170277","article-title":"CCL22 controls immunity by promoting regulatory T cell communication with dendritic cells in lymph nodes","volume":"216","author":"Rapp","year":"2019","journal-title":"J. Exp. Med."},{"issue":"11","key":"10.1016\/j.bbi.2025.106185_b0410","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1002\/da.22790","article-title":"The association between anxiety, traumatic stress, and obsessive-compulsive disorders and chronic inflammation: a systematic review and meta-analysis","volume":"35","author":"Renna","year":"2018","journal-title":"Depress. Anxiety"},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0415","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.pain.2010.05.031","article-title":"Chronic stress induces transient spinal neuroinflammation, triggering sensory hypersensitivity and long-lasting anxiety-induced hyperalgesia","volume":"150","author":"Rivat","year":"2010","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2025.106185_b0420","series-title":"International Conference on Medical Image Computing and Computer-Assisted Intervention","article-title":"U-net: Convolutional networks for biomedical image segmentation","author":"Ronneberger","year":"2015"},{"issue":"7","key":"10.1016\/j.bbi.2025.106185_b0425","doi-asserted-by":"crossref","first-page":"e65","DOI":"10.1097\/j.pain.0000000000003175","article-title":"Unraveling the neuroimmune interface in chronic pain-the association between cytokines in the cerebrospinal fluid and pain in patients with lumbar disk herniation or degenerative disk disease","volume":"165","author":"Rosenstr\u00f6m","year":"2024","journal-title":"Pain"},{"issue":"7","key":"10.1016\/j.bbi.2025.106185_b0430","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0435","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1046\/j.1365-2249.1999.00935.x","article-title":"Soluble CD40 in the serum of healthy donors, patients with chronic renal failure, haemodialysis and chronic ambulatory peritoneal dialysis (CAPD) patients","volume":"117","author":"Schwabe","year":"1999","journal-title":"Clin. Exp. Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0440","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1002\/ana.24065","article-title":"Hyperexcitable C nociceptors in fibromyalgia","volume":"75","author":"Serra","year":"2014","journal-title":"Ann. Neurol."},{"issue":"3","key":"10.1016\/j.bbi.2025.106185_b0445","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1016\/0022-3999(94)00125-O","article-title":"The Multidimensional Fatigue Inventory (MFI) psychometric qualities of an instrument to assess fatigue","volume":"39","author":"Smets","year":"1995","journal-title":"J. Psychosom. Res."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0450","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1600-065X.2011.01064.x","article-title":"The signaling networks of the herpesvirus entry mediator (TNFRSF14) in immune regulation","volume":"244","author":"Steinberg","year":"2011","journal-title":"Immunol. Rev."},{"issue":"4","key":"10.1016\/j.bbi.2025.106185_b0455","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1037\/1040-3590.7.4.524","article-title":"The pain catastrophizing scale: development and validation","volume":"7","author":"Sullivan","year":"1995","journal-title":"Psychol. Assess."},{"issue":"D1","key":"10.1016\/j.bbi.2025.106185_b0460","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbi.2025.106185_b0465","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.783725","article-title":"Interferons in Pain and Infections: Emerging Roles in Neuro-Immune and Neuro-Glial Interactions","volume":"12","author":"Tan","year":"2021","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.bbi.2025.106185_b0470","doi-asserted-by":"crossref","first-page":"3322","DOI":"10.1021\/acs.jproteome.5b00354","article-title":"Analysis of the Human Adult Urinary Metabolome Variations with Age, Body Mass Index, and Gender by Implementing a Comprehensive Workflow for Univariate and OPLS Statistical analyses","volume":"14","author":"Th\u00e9venot","year":"2015","journal-title":"J. Proteome Res."},{"issue":"6","key":"10.1016\/j.bbi.2025.106185_b0475","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1046\/j.1469-7580.2002.00061.x","article-title":"Complementary actions of VEGF and angiopoietin-1 on blood vessel growth and leakage","volume":"200","author":"Thurston","year":"2002","journal-title":"J. Anat."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0480","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25010010","article-title":"B-Cell Receptor Signaling and beyond: the Role of Ig\u03b1 (CD79a)\/Ig\u03b2 (CD79b) in Normal and Malignant B Cells","volume":"25","author":"Tkachenko","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2025.106185_b0485","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1186\/1471-2474-12-245","article-title":"Systematic review with meta-analysis: cytokines in fibromyalgia syndrome","volume":"12","author":"U\u00e7eyler","year":"2011","journal-title":"BMC Musculoskelet. Disord."},{"issue":"6","key":"10.1016\/j.bbi.2025.106185_b0490","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1016\/j.celrep.2014.02.010","article-title":"Calsyntenins function as synaptogenic adhesion molecules in concert with neurexins","volume":"6","author":"Um","year":"2014","journal-title":"Cell Rep."},{"issue":"4","key":"10.1016\/j.bbi.2025.106185_b0495","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1080\/02813430701706568","article-title":"The fibromyalgia diagnosis: hardly helpful for the patients? a qualitative focus group study","volume":"25","author":"Undeland","year":"2007","journal-title":"Scand. J. Prim. Health Care"},{"issue":"5","key":"10.1016\/j.bbi.2025.106185_b0500","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1159\/000078843","article-title":"Fibromyalgia: a stress disorder? Piecing the biopsychosocial puzzle together","volume":"73","author":"Van Houdenhove","year":"2004","journal-title":"Psychother. Psychosom."},{"issue":"22","key":"10.1016\/j.bbi.2025.106185_b0505","doi-asserted-by":"crossref","first-page":"5813","DOI":"10.1182\/blood-2011-05-356873","article-title":"IL-36R ligands are potent regulators of dendritic and T cells","volume":"118","author":"Vigne","year":"2011","journal-title":"Blood"},{"issue":"4","key":"10.1016\/j.bbi.2025.106185_b0510","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1016\/j.gendis.2021.04.003","article-title":"Targeting LIF\/LIFR signaling in cancer","volume":"9","author":"Viswanadhapalli","year":"2022","journal-title":"Genes Dis"},{"key":"10.1016\/j.bbi.2025.106185_b0515","series-title":"2022 IEEE International Symposium on Biomedical Imaging Challenges (ISBIC)","article-title":"Nuclei instance segmentation and classification in histopathology images with stardist","author":"Weigert","year":"2022"},{"issue":"3","key":"10.1016\/j.bbi.2025.106185_b0520","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/j.semarthrit.2016.08.012","article-title":"2016 Revisions to the 2010\/2011 fibromyalgia diagnostic criteria","volume":"46","author":"Wolfe","year":"2016","journal-title":"Semin. Arthritis Rheum."},{"issue":"5","key":"10.1016\/j.bbi.2025.106185_b0525","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity","volume":"62","author":"Wolfe","year":"2010","journal-title":"Arthritis Care Res (hoboken)"},{"issue":"2","key":"10.1016\/j.bbi.2025.106185_b0530","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1002\/art.1780330203","article-title":"The American College of Rheumatology 1990 Criteria for the Classification of Fibromyalgia. Report of the Multicenter Criteria Committee","volume":"33","author":"Wolfe","year":"1990","journal-title":"Arthritis Rheum."},{"issue":"1","key":"10.1016\/j.bbi.2025.106185_b0535","doi-asserted-by":"crossref","first-page":"12508","DOI":"10.1038\/s41598-020-69422-z","article-title":"Significant correlation between plasma proteome profile and pain intensity, sensitivity, and psychological distress in women with fibromyalgia","volume":"10","author":"W\u00e5hl\u00e9n","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2025.106185_b0540","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.semcdb.2014.01.011","article-title":"Epidermal growth factor, from gene organization to bedside","volume":"28","author":"Zeng","year":"2014","journal-title":"Semin. Cell Dev. Biol."},{"issue":"3","key":"10.1016\/j.bbi.2025.106185_b0545","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2019.06.005","article-title":"The prevalence and impact of comorbid fibromyalgia in inflammatory arthritis","volume":"33","author":"Zhao","year":"2019","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"issue":"6","key":"10.1016\/j.bbi.2025.106185_b0550","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr. Scand."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125004271?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159125004271?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T05:43:24Z","timestamp":1773899004000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159125004271"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":110,"alternative-id":["S0889159125004271"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2025.106185","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Searching for blood biomarkers and treatment targets in Women with fibromyalgia \u2013 Protein interaction patterns and anti-satellite glia cell IgG antibodies as promising candidates","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2025.106185","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106185"}}