{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T09:48:19Z","timestamp":1789984099495,"version":"4.0.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82274334"],"award-info":[{"award-number":["82274334"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82205084"],"award-info":[{"award-number":["82205084"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbi.2026.106273","type":"journal-article","created":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T16:52:49Z","timestamp":1767891169000},"page":"106273","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis"],"prefix":"10.1016","volume":"135","author":[{"given":"Jing","family":"Qiu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guang","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingling","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shiting","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haohao","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lianting","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bbi.2026.106273_b0005","doi-asserted-by":"crossref","first-page":"1527","DOI":"10.1038\/s41590-022-01321-z","article-title":"The neuroimmunology of social-stress-induced sensitization","volume":"23","author":"Biltz","year":"2022","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbi.2026.106273_b0010","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3389\/fphar.2020.00091","article-title":"Treatment with 2-pentadecyl-2-oxazoline restores mild traumatic brain injury-induced sensorial and neuropsychiatric dysfunctions","volume":"11","author":"Boccella","year":"2020","journal-title":"Front. Pharmacol."},{"issue":"38","key":"10.1016\/j.bbi.2026.106273_b0015","article-title":"Hypocretin-1\/hypocretin receptor 1 regulates neuroplasticity and cognitive function through hippocampal lactate homeostasis in depressed model","volume":"11","author":"Chen","year":"2024","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"7","key":"10.1016\/j.bbi.2026.106273_b0020","doi-asserted-by":"crossref","first-page":"1590","DOI":"10.1038\/mp.2017.130","article-title":"A direct test of the diathesis-stress model for depression","volume":"23","author":"Colodro-Conde","year":"2018","journal-title":"Mol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2026.106273_b0025","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1186\/s12974-020-01973-4","article-title":"Inhibiting HMGB1-RAGE axis prevents pro-inflammatory macrophages\/microglia polarization and affords neuroprotection after spinal cord injury","volume":"17","author":"Fan","year":"2020","journal-title":"J. Neuroinflammation"},{"issue":"7","key":"10.1016\/j.bbi.2026.106273_b0030","doi-asserted-by":"crossref","DOI":"10.1172\/JCI160016","article-title":"O-GlcNAc transferase in astrocytes modulates depression-related stress susceptibility through glutamatergic synaptic transmission","volume":"133","author":"Fan","year":"2023","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2026.106273_b0035","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1016\/j.ynstr.2015.12.004","article-title":"Stress-induced neuroinflammatory priming: a liability factor in the etiology of psychiatric disorders","volume":"4","author":"Frank","year":"2016","journal-title":"Neurobiol. Stress"},{"issue":"8","key":"10.1016\/j.bbi.2026.106273_b0040","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1016\/S1474-4422(20)30182-4","article-title":"Clinical characteristics and outcomes in patients with traumatic brain injury in China: a prospective, multicentre, longitudinal, observational study","volume":"19","author":"Gao","year":"2020","journal-title":"Lancet Neurol."},{"issue":"11","key":"10.1016\/j.bbi.2026.106273_b0045","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1089\/neu.2013.3283","article-title":"Impact of depression and post-traumatic stress disorder on functional outcome and health-related quality of life of patients with mild traumatic brain injury","volume":"32","author":"Haagsma","year":"2015","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbi.2026.106273_b0050","doi-asserted-by":"crossref","first-page":"350","DOI":"10.3389\/fneur.2020.00350","article-title":"Characterizing the risk of depression following mild traumatic brain injury: a meta-analysis of the literature comparing chronic mtbi to non-mTBI populations","volume":"11","author":"Hellewell","year":"2020","journal-title":"Front Neurol."},{"key":"10.1016\/j.bbi.2026.106273_b0055","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/j.pharmthera.2019.02.016","article-title":"Animal models of closed-skull, repetitive mild traumatic brain injury","volume":"198","author":"Hoogenboom","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2026.106273_b0060","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1146\/annurev-med-041316-085215","article-title":"Targeting RAGE signaling in inflammatory disease","volume":"69","author":"Hudson","year":"2018","journal-title":"Annu. Rev. Med."},{"issue":"4","key":"10.1016\/j.bbi.2026.106273_b0065","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.molimm.2013.07.008","article-title":"RAGE and TLRs: relatives, friends or neighbours?","volume":"56","author":"Ibrahim","year":"2013","journal-title":"Mol. Immunol."},{"key":"10.1016\/j.bbi.2026.106273_b0070","first-page":"38","article-title":"ROS-responsive 18\u03b2-glycyrrhetic acid-conjugated polymeric nanoparticles mediate neuroprotection in ischemic stroke through HMGB1 inhibition and microglia polarization regulation","volume":"19","author":"Jin","year":"2023","journal-title":"Bioact. Mater."},{"issue":"7","key":"10.1016\/j.bbi.2026.106273_b0075","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1176\/appi.ajp.2020.19111213","article-title":"A prehistory of the diathesis-stress model: predisposing and exciting causes of insanity in the 19th century","volume":"177","author":"Kendler","year":"2020","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106273_b0080","doi-asserted-by":"crossref","first-page":"17042","DOI":"10.1038\/boneres.2017.42","article-title":"Experimental repetitive mild traumatic brain injury induces deficits in trabecular bone microarchitecture and strength in mice","volume":"5","author":"Kesavan","year":"2017","journal-title":"Bone Res."},{"key":"10.1016\/j.bbi.2026.106273_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2024.115244","article-title":"Sex-dependent perturbations in risky choice behavior and prefrontal tyrosine hydroxylase levels induced by repetitive mild traumatic brain injury","volume":"476","author":"Knapp","year":"2025","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2026.106273_b0090","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2024.111153","article-title":"Augmentation of psychiatric symptom onset vulnerability in male mice due to mild traumatic brain injury","volume":"136","author":"Koga","year":"2025","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"8","key":"10.1016\/j.bbi.2026.106273_b0095","doi-asserted-by":"crossref","first-page":"3703","DOI":"10.7150\/thno.72144","article-title":"P2X2 receptors in pyramidal neurons are critical for regulating vulnerability to chronic stress","volume":"12","author":"Kuang","year":"2022","journal-title":"Theranostics"},{"key":"10.1016\/j.bbi.2026.106273_b0100","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.bbi.2021.01.022","article-title":"Acute and late administration of colony stimulating factor 1 attenuates chronic cognitive impairment following mild traumatic brain injury in mice","volume":"94","author":"Li","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"12","key":"10.1016\/j.bbi.2026.106273_b0105","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","article-title":"Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research","volume":"16","author":"Maas","year":"2017","journal-title":"Lancet Neurol."},{"issue":"11","key":"10.1016\/j.bbi.2026.106273_b0110","doi-asserted-by":"crossref","first-page":"1004","DOI":"10.1016\/S1474-4422(22)00309-X","article-title":"Traumatic brain injury: progress and challenges in prevention, clinical care, and research","volume":"21","author":"Maas","year":"2022","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.bbi.2026.106273_b0115","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1001\/jamaneurol.2017.0143","article-title":"Early clinical predictors of 5-year outcome after concussive blast traumatic brain injury","volume":"74","author":"Mac Donald","year":"2017","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbi.2026.106273_b0120","doi-asserted-by":"crossref","DOI":"10.2340\/jrm.v56.13438","article-title":"Stressful life events are associated with self-reported fatigue and depressive symptoms in patients with mild traumatic brain injury","volume":"56","author":"M\u00e4ki","year":"2024","journal-title":"J. Rehabil. Med."},{"issue":"4","key":"10.1016\/j.bbi.2026.106273_b0125","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1089\/neu.2018.5720","article-title":"Chronic white matter degeneration, but no Tau pathology at one-year post-repetitive mild traumatic brain injury in a tau transgenic model","volume":"36","author":"Mouzon","year":"2019","journal-title":"J. Neurotrauma"},{"issue":"Pt A","key":"10.1016\/j.bbi.2026.106273_b0130","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuropharm.2014.10.028","article-title":"Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease","volume":"96","author":"Norden","year":"2015","journal-title":"Neuropharmacology"},{"issue":"2","key":"10.1016\/j.bbi.2026.106273_b0135","doi-asserted-by":"crossref","DOI":"10.1111\/bpa.13034","article-title":"Axonal injury following mild traumatic brain injury is exacerbated by repetitive insult and is linked to the delayed attenuation of NeuN expression without concomitant neuronal death in the mouse","volume":"32","author":"Ogino","year":"2022","journal-title":"Brain Pathol."},{"issue":"2","key":"10.1016\/j.bbi.2026.106273_b0140","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1097\/NEN.0b013e3182814cdf","article-title":"Repetitive mild traumatic brain injury augments tau pathology and glial activation in aged hTau mice","volume":"72","author":"Ojo","year":"2013","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbi.2026.106273_b0145","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcn.2023.103855","article-title":"Deletion of PTEN in microglia ameliorates chronic neuroinflammation following repetitive mTBI","volume":"125","author":"Pearson","year":"2023","journal-title":"Mol. Cell Neurosci."},{"issue":"4","key":"10.1016\/j.bbi.2026.106273_b0150","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nrneurol.2014.38","article-title":"Microglial priming in neurodegenerative disease","volume":"10","author":"Perry","year":"2014","journal-title":"Nat. Rev. Neurol."},{"issue":"9\u201310","key":"10.1016\/j.bbi.2026.106273_b0155","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1089\/neu.2023.0654","article-title":"Translational outcomes project in neurotrauma (TOP-NT) pre-clinical consortium study: a synopsis","volume":"42","author":"Radabaugh","year":"2025","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbi.2026.106273_b0160","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2024.102550","article-title":"HMGB1, an evolving pleiotropic protein critical for cellular and tissue homeostasis: Role in aging and age-related diseases","volume":"102","author":"Ruggieri","year":"2024","journal-title":"Ageing Res Rev."},{"issue":"7","key":"10.1016\/j.bbi.2026.106273_b0165","doi-asserted-by":"crossref","first-page":"4663","DOI":"10.1002\/alz.13898","article-title":"Serum NfL and GFAP as biomarkers of progressive neurodegeneration in TBI","volume":"20","author":"Shahim","year":"2024","journal-title":"Alzheimers Dement."},{"issue":"11","key":"10.1016\/j.bbi.2026.106273_b0170","article-title":"Microglia-derived interleukin-6 triggers astrocyte apoptosis in the hippocampus and mediates depression-like behavior","volume":"12","author":"Shen","year":"2025","journal-title":"Adv. Sci. (Weinh.)"},{"issue":"1","key":"10.1016\/j.bbi.2026.106273_b0175","doi-asserted-by":"crossref","DOI":"10.1080\/20008198.2020.1815279","article-title":"Preliminary study examining the mediational link between mild traumatic brain injury, acute stress, and post-traumatic stress symptoms following trauma","volume":"11","author":"Shih","year":"2020","journal-title":"Eur. J. Psychotraumatol."},{"issue":"Pt B","key":"10.1016\/j.bbi.2026.106273_b0180","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1016\/j.neubiorev.2016.09.014","article-title":"The potential for animal models to provide insight into mild traumatic brain injury: Translational challenges and strategies","volume":"76","author":"Shultz","year":"2017","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.bbi.2026.106273_b0185","first-page":"177","article-title":"Mild traumatic brain injury in 2019-2020","volume":"323","author":"Silverberg","year":"2020","journal-title":"Jama"},{"issue":"9","key":"10.1016\/j.bbi.2026.106273_b0190","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1038\/nrneurol.2017.116","article-title":"The far-reaching scope of neuroinflammation after traumatic brain injury","volume":"13","author":"Simon","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2026.106273_b0195","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2023.578106","article-title":"Repeated mild traumatic brain injury in mice elicits long term innate immune cell alterations in blood, spleen, and brain","volume":"380","author":"Smith","year":"2023","journal-title":"J. Neuroimmunol."},{"issue":"7","key":"10.1016\/j.bbi.2026.106273_b0200","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1016\/j.bbi.2010.02.001","article-title":"Chronic stress alters the density and morphology of microglia in a subset of stress-responsive brain regions","volume":"24","author":"Tynan","year":"2010","journal-title":"Brain. Behav. Immun."},{"issue":"7","key":"10.1016\/j.bbi.2026.106273_b0205","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1136\/jnnp.2010.228254","article-title":"Predictive ability of preinjury stressful life events and post-traumatic stress symptoms for outcomes following mild traumatic brain injury: analysis in a prospective emergency room sample","volume":"82","author":"Van Veldhoven","year":"2011","journal-title":"J. Neurol. Neurosurg. Psychiatry."},{"issue":"5\u20136","key":"10.1016\/j.bbi.2026.106273_b0210","doi-asserted-by":"crossref","first-page":"578","DOI":"10.1089\/neu.2022.0335","article-title":"Mild traumatic brain injury induces time- and sex-dependent cerebrovascular dysfunction and stroke vulnerability","volume":"40","author":"Whitehead","year":"2023","journal-title":"J. Neurotrauma"},{"issue":"1","key":"10.1016\/j.bbi.2026.106273_b0215","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s10565-024-09893-2","article-title":"HMGB1 as an extracellular pro-inflammatory cytokine: Implications for drug-induced organic damage","volume":"40","author":"Yuan","year":"2024","journal-title":"Cell Biol. Toxicol."},{"key":"10.1016\/j.bbi.2026.106273_b0220","article-title":"Astrocyte-mediated inflammatory responses in traumatic brain injury: mechanisms and potential interventions","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2026.106273_b0225","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adj4260","article-title":"Targeting pyroptosis with nanoparticles to alleviate neuroinflammatory for preventing secondary damage following traumatic brain injury","volume":"10","author":"Zhang","year":"2024","journal-title":"Sci. Adv."},{"issue":"37","key":"10.1016\/j.bbi.2026.106273_b0230","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.adx2666","article-title":"Acute REM sleep deprivation alleviated depression-like behavior mediated by inhibiting VIP neurons in the mPFC","volume":"11","author":"Zhu","year":"2025","journal-title":"Sci. Adv."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126000218?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126000218?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:20:44Z","timestamp":1781061644000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126000218"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":46,"alternative-id":["S0889159126000218"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106273","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Injury-environment interaction: microglial priming by mTBI creates vulnerability to subsequent stress via the HMGB1-RAGE axis","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106273","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106273"}}