{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,26]],"date-time":"2026-10-26T17:26:53Z","timestamp":1793035613055,"version":"4.5.0"},"reference-count":83,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T00:00:00Z","timestamp":1777593600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,1,12]],"date-time":"2026-01-12T00:00:00Z","timestamp":1768176000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100011272","name":"European Commission Seventh Framework Programme for Research and Technological Development Health","doi-asserted-by":"publisher","award":["602461"],"award-info":[{"award-number":["602461"]}],"id":[{"id":"10.13039\/100011272","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100011102","name":"Seventh Framework Programme","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011102","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002839","name":"Charit\u00e9 \u2013 Universit\u00e4tsmedizin Berlin","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100002839","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100017268","name":"Berlin Institute of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100017268","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,5]]},"DOI":"10.1016\/j.bbi.2026.106283","type":"journal-article","created":{"date-parts":[[2026,1,14]],"date-time":"2026-01-14T16:14:04Z","timestamp":1768407244000},"page":"106283","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Altered gene expression associated with postoperative delirium in patients undergoing surgery and anesthesia"],"prefix":"10.1016","volume":"134","author":[{"given":"Maria","family":"Heinrich","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna-Rosa","family":"Kr\u00fcger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sreyoshi","family":"Chatterjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anna","family":"Fournier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7371-3947","authenticated-orcid":false,"given":"Florian","family":"Lammers-Lietz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roland","family":"Krause","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"N\u00fcrnberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard","family":"Schneider","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georg","family":"Winterer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maik","family":"Pietzner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Spies","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbi.2026.106283_b0005","doi-asserted-by":"crossref","first-page":"R257","DOI":"10.1186\/cc13084","article-title":"Outcome and quality of life in patients with postoperative delirium during an ICU stay following major surgery","volume":"17","author":"Abelha","year":"2013","journal-title":"Crit. Care"},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0010","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1097\/EJA.0000000000000594","article-title":"European Society of Anaesthesiology evidence-based and consensus-based guideline on postoperative delirium","volume":"34","author":"Aldecoa","year":"2017","journal-title":"Eur. J. Anaesthesiol."},{"issue":"2","key":"10.1016\/j.bbi.2026.106283_b0015","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1097\/EJA.0000000000001876","article-title":"Update of the European Society of Anaesthesiology and Intensive Care Medicine evidence-based and consensus-based guideline on postoperative delirium in adult patients","volume":"41","author":"Aldecoa","year":"2024","journal-title":"Eur. J. Anaesthesiol."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0020","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.3233\/JAD-201080","article-title":"Hemochromatosis mutations, brain iron imaging, and dementia in the UK Biobank Cohort","volume":"79","author":"Atkins","year":"2021","journal-title":"J. Alzheimers Dis."},{"issue":"2","key":"10.1016\/j.bbi.2026.106283_b0025","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.bja.2020.08.061","article-title":"Association between plasma tau and postoperative delirium incidence and severity: a prospective observational study","volume":"126","author":"Ballweg","year":"2021","journal-title":"Br. J. Anaesth."},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0030","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.blre.2009.04.001","article-title":"Platelet alpha-granules: basic biology and clinical correlates","volume":"23","author":"Blair","year":"2009","journal-title":"Blood Rev."},{"issue":"7343","key":"10.1016\/j.bbi.2026.106283_b0035","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1038\/nature09788","article-title":"Caspase signalling controls microglia activation and neurotoxicity","volume":"472","author":"Burguillos","year":"2011","journal-title":"Nature"},{"issue":"6","key":"10.1016\/j.bbi.2026.106283_b0040","article-title":"Antipsychotics for treatment of delirium in hospitalised non-ICU patients","volume":"6","author":"Burry","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"11","key":"10.1016\/j.bbi.2026.106283_b0045","article-title":"Non-pharmacological interventions for preventing delirium in hospitalised non-ICU patients","volume":"11","author":"Burton","year":"2021","journal-title":"Cochrane Database Syst. Rev."},{"issue":"18","key":"10.1016\/j.bbi.2026.106283_b0050","doi-asserted-by":"crossref","first-page":"8836","DOI":"10.7150\/thno.63396","article-title":"Role of prostaglandin E2 in tissue repair and regeneration","volume":"11","author":"Cheng","year":"2021","journal-title":"Theranostics"},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0055","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1042\/BST0390945","article-title":"Systemic inflammation and delirium: important co-factors in the progression of dementia","volume":"39","author":"Cunningham","year":"2011","journal-title":"Biochem. Soc. Trans."},{"issue":"9","key":"10.1016\/j.bbi.2026.106283_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/biom13091395","article-title":"Aptamer-based proteomics measuring preoperative cerebrospinal fluid protein alterations associated with postoperative delirium","volume":"13","author":"Dillon","year":"2023","journal-title":"Biomolecules"},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0065","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1097\/EJA.0000000000000107","article-title":"Postoperative delirium is an independent risk factor for posttraumatic stress disorder in the elderly patient: a prospective observational study","volume":"32","author":"Drews","year":"2015","journal-title":"Eur. J. Anaesthesiol."},{"key":"10.1016\/j.bbi.2026.106283_b0070","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.2147\/CIA.S137182","article-title":"Increased neutrophil-lymphocyte ratio in delirium: a pilot study","volume":"12","author":"Egberts","year":"2017","journal-title":"Clin. Interv. Aging"},{"key":"10.1016\/j.bbi.2026.106283_b0075","doi-asserted-by":"crossref","first-page":"271","DOI":"10.2147\/CIA.S193605","article-title":"Differences in potential biomarkers of delirium between acutely ill medical and elective cardiac surgery patients","volume":"14","author":"Egberts","year":"2019","journal-title":"Clin. Interv. Aging"},{"issue":"7","key":"10.1016\/j.bbi.2026.106283_b0080","doi-asserted-by":"crossref","first-page":"1370","DOI":"10.1097\/00003246-200107000-00012","article-title":"Evaluation of delirium in critically ill patients: validation of the confusion Assessment Method for the Intensive Care Unit (CAM-ICU)","volume":"29","author":"Ely","year":"2001","journal-title":"Crit. Care Med."},{"issue":"7","key":"10.1016\/j.bbi.2026.106283_b0085","doi-asserted-by":"crossref","first-page":"3259","DOI":"10.18632\/aging.204011","article-title":"Cholesterol-induced leucine aminopeptidase 3 (LAP3) upregulation inhibits cell autophagy in pathogenesis of NAFLD","volume":"14","author":"Feng","year":"2022","journal-title":"Aging (Albany NY)"},{"key":"10.1016\/j.bbi.2026.106283_b0090","first-page":"112","article-title":"Biomarkers of postoperative delirium and cognitive dysfunction","volume":"7","author":"Fournier","year":"2015","journal-title":"Front. Aging Neurosci."},{"issue":"8","key":"10.1016\/j.bbi.2026.106283_b0095","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.1002\/bjs.11148","article-title":"Age of patients undergoing surgery","volume":"106","author":"Fowler","year":"2019","journal-title":"Br. J. Surg."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0100","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.jvs.2017.03.439","article-title":"Risk factors for postoperative delirium in patients undergoing vascular surgery","volume":"66","author":"Galyfos","year":"2017","journal-title":"J. Vasc. Surg."},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0105","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.jpainsymman.2004.07.009","article-title":"Fast, systematic, and continuous delirium assessment in hospitalized patients: the nursing delirium screening scale","volume":"29","author":"Gaudreau","year":"2005","journal-title":"J. Pain Symptom Manage."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0110","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1016\/j.ncl.2006.03.010","article-title":"Age and neuroinflammation: a lifetime of psychoneuroimmune consequences","volume":"24","author":"Godbout","year":"2006","journal-title":"Neurol. Clin."},{"issue":"1","key":"10.1016\/j.bbi.2026.106283_b0115","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1186\/s12974-016-0636-1","article-title":"Cerebrospinal fluid levels of neopterin are elevated in delirium after hip fracture","volume":"13","author":"Hall","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"5","key":"10.1016\/j.bbi.2026.106283_b0120","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1111\/j.1600-0447.1980.tb00640.x","article-title":"Haematological changes and state of hydration during delirium tremens and related clinical states","volume":"62","author":"Hemmingsen","year":"1980","journal-title":"Acta Psychiatr. Scand."},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0125","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1097\/SLA.0000000000001952","article-title":"Trajectory of functional recovery after postoperative delirium in elective surgery","volume":"265","author":"Hshieh","year":"2017","journal-title":"Ann. Surg."},{"issue":"12","key":"10.1016\/j.bbi.2026.106283_b0130","doi-asserted-by":"crossref","first-page":"941","DOI":"10.7326\/0003-4819-113-12-941","article-title":"Clarifying confusion: the confusion assessment method. a new method for detection of delirium","volume":"113","author":"Inouye","year":"1990","journal-title":"Ann. Intern. Med."},{"issue":"7","key":"10.1016\/j.bbi.2026.106283_b0135","doi-asserted-by":"crossref","first-page":"766","DOI":"10.1016\/j.jalz.2016.03.005","article-title":"The short-term and long-term relationship between delirium and cognitive trajectory in older surgical patients","volume":"12","author":"Inouye","year":"2016","journal-title":"Alzheimers Dement."},{"issue":"2","key":"10.1016\/j.bbi.2026.106283_b0140","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1093\/biostatistics\/4.2.249","article-title":"Exploration, normalization, and summaries of high density oligonucleotide array probe level data","volume":"4","author":"Irizarry","year":"2003","journal-title":"Biostatistics"},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0145","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1177\/0891988718785774","article-title":"Whole-genome mRNA gene expression differs between patients with and without delirium","volume":"31","author":"Kalantar","year":"2018","journal-title":"J. Geriatr. Psychiatry Neurol."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0150","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1093\/bioinformatics\/btn647","article-title":"arrayQualityMetrics\u2013a bioconductor package for quality assessment of microarray data","volume":"25","author":"Kauffmann","year":"2009","journal-title":"Bioinformatics"},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0155","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.athoracsur.2021.03.035","article-title":"Serum biomarkers in postoperative delirium after esophagectomy","volume":"113","author":"Khan","year":"2022","journal-title":"Ann. Thorac. Surg."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2026.106283_b0160","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1007\/s11481-021-10003-w","article-title":"Dexmedetomidine restores autophagic flux, modulates associated microRNAs and the cholinergic anti-inflammatory pathway upon LPS-treatment in rats","volume":"17","author":"Kho","year":"2022","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0165","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1001\/jamainternmed.2018.6738","article-title":"Evaluation of changes in functional status in the year after aortic valve replacement","volume":"179","author":"Kim","year":"2019","journal-title":"JAMA Intern. Med."},{"issue":"9","key":"10.1016\/j.bbi.2026.106283_b0170","doi-asserted-by":"crossref","DOI":"10.1177\/03000605251363408","article-title":"Postoperative delirium after short-acting spinal anesthesia and general anesthesia after shared decision-making","volume":"53","author":"Kipping","year":"2025","journal-title":"J. Int. Med. Res."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0175","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5090\/jcs.23.159","article-title":"Immunological analysis of postoperative delirium after thoracic aortic surgery","volume":"57","author":"Ko","year":"2024","journal-title":"J Chest Surg."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0180","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/1710-1492-2-3-98","article-title":"Mechanisms of degranulation in neutrophils","volume":"2","author":"Lacy","year":"2006","journal-title":"Allergy Asthma Clin. Immunol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106283_b0185","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.biocel.2009.09.013","article-title":"Caspase-7: a protease involved in apoptosis and inflammation","volume":"42","author":"Lamkanfi","year":"2010","journal-title":"Int. J. Biochem. Cell Biol."},{"key":"10.1016\/j.bbi.2026.106283_b0190","article-title":"Interleukin 8 in postoperative delirium - Preliminary findings from two studies","volume":"20","author":"Lammers-Lietz","year":"2022","journal-title":"Brain Behav. Immun. Health"},{"issue":"10","key":"10.1016\/j.bbi.2026.106283_b0195","doi-asserted-by":"crossref","first-page":"2646","DOI":"10.1111\/ejn.16282","article-title":"An exploratory research report on brain mineralization in postoperative delirium and cognitive decline","volume":"59","author":"Lammers-Lietz","year":"2024","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106283_b0200","doi-asserted-by":"crossref","unstructured":"Lammers-Lietz, F., Akyuez, L., Boraschi, D., Borchers F, de Bresser J, Chatterjee S, et al., 2024. Development and internal validation of a gradient-boosted trees model for prediction of delirium after surgery and anesthesia (the BioCog study). medRxiv. 12 (30) 24319760.","DOI":"10.1101\/2024.12.30.24319760"},{"key":"10.1016\/j.bbi.2026.106283_b0205","doi-asserted-by":"crossref","unstructured":"Lamping, M., Heinrich M, Farztdinov V, von Haefen C, Sreekanth J, M\u00fclleder M, et al., 2025. Mechanistic Insights Into Postoperative Delirium Using Untargeted High-Throughput Proteomics in Elderly Patients - A Case-Control Study. medRxiv. 05 (05) 25326969.","DOI":"10.1101\/2025.05.05.25326969"},{"issue":"7884","key":"10.1016\/j.bbi.2026.106283_b0210","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1038\/s41586-021-03995-1","article-title":"Virus-induced senescence is a driver and therapeutic target in COVID-19","volume":"599","author":"Lee","year":"2021","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2026.106283_b0215","article-title":"Early alteration of peripheral blood lymphocyte subsets as a risk factor for delirium in critically ill patients after cardiac surgery: a prospective observational study","volume":"14","author":"Li","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbi.2026.106283_b0220","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2023.1174644","article-title":"Biomarkers of delirium risk in older adults: a systematic review and meta-analysis","volume":"15","author":"Lozano-Vicario","year":"2023","journal-title":"Front. Aging Neurosci."},{"issue":"6","key":"10.1016\/j.bbi.2026.106283_b0225","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1532-5415.2011.03428.x","article-title":"Cerebrospinal fluid interleukin-8 levels are higher in people with hip fracture with perioperative delirium than in controls","volume":"59","author":"MacLullich","year":"2011","journal-title":"J. Am. Geriatr. Soc."},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0230","doi-asserted-by":"crossref","DOI":"10.1016\/j.ccc.2008.06.004","article-title":"Pathoetiological model of delirium: a comprehensive understanding of the neurobiology of delirium and an evidence-based approach to prevention and treatment","volume":"24","author":"Maldonado","year":"2008","journal-title":"Crit. Care Clin."},{"issue":"12","key":"10.1016\/j.bbi.2026.106283_b0235","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1016\/j.jagp.2013.09.005","article-title":"Neuropathogenesis of delirium: review of current etiologic theories and common pathways","volume":"21","author":"Maldonado","year":"2013","journal-title":"Am. J. Geriatr. Psychiatry"},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0240","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1016\/j.ccc.2017.03.013","article-title":"Acute brain failure: pathophysiology, diagnosis, management, and sequelae of delirium","volume":"33","author":"Maldonado","year":"2017","journal-title":"Crit. Care Clin."},{"issue":"11","key":"10.1016\/j.bbi.2026.106283_b0245","doi-asserted-by":"crossref","first-page":"1428","DOI":"10.1002\/gps.4823","article-title":"Delirium pathophysiology: an updated hypothesis of the etiology of acute brain failure","volume":"33","author":"Maldonado","year":"2018","journal-title":"Int. J. Geriatr. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2026.106283_b0250","doi-asserted-by":"crossref","first-page":"e254","DOI":"10.1016\/j.bja.2022.05.032","article-title":"Perioperative risk factors associated with increased incidence of postoperative delirium: systematic review, meta-analysis, and Grading of Recommendations Assessment, Development, and Evaluation system report of clinical literature","volume":"130","author":"Mevorach","year":"2023","journal-title":"Br. J. Anaesth."},{"issue":"8","key":"10.1016\/j.bbi.2026.106283_b0255","article-title":"Intravenous versus inhalational maintenance of anaesthesia for postoperative cognitive outcomes in elderly people undergoing non-cardiac surgery","volume":"8","author":"Miller","year":"2018","journal-title":"Cochrane Database Syst. Rev."},{"issue":"6","key":"10.1016\/j.bbi.2026.106283_b0260","doi-asserted-by":"crossref","DOI":"10.1093\/braincomms\/fcad270","article-title":"EEG microstate quantifiers and state space descriptors during anaesthesia in patients with postoperative delirium: a descriptive analysis","volume":"5","author":"Neuner","year":"2023","journal-title":"Brain Commun."},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0265","doi-asserted-by":"crossref","DOI":"10.3390\/ph11040109","article-title":"New perspectives in iron chelation therapy for the treatment of neurodegenerative diseases","volume":"11","author":"Nunez","year":"2018","journal-title":"Pharmaceuticals (Basel)"},{"issue":"19","key":"10.1016\/j.bbi.2026.106283_b0270","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1101\/gad.992102","article-title":"Identification of a polymorphic, neuron-specific chromatin remodeling complex","volume":"16","author":"Olave","year":"2002","journal-title":"Genes Dev."},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0275","doi-asserted-by":"crossref","first-page":"1269","DOI":"10.1016\/j.jvs.2017.04.077","article-title":"A systematic review and meta-analysis of factors for delirium in vascular surgical patients","volume":"66","author":"Oldroyd","year":"2017","journal-title":"J. Vasc. Surg."},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0280","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1532-5415.2011.03885.x","article-title":"High preoperative plasma neopterin predicts delirium after cardiac surgery in older adults","volume":"60","author":"Osse","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0285","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41577-020-00452-4","article-title":"gammadelta T cells in tissue physiology and surveillance","volume":"21","author":"Ribot","year":"2021","journal-title":"Nat. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.bbi.2026.106283_b0290","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1189\/jlb.1008606","article-title":"Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP","volume":"86","author":"Rorvig","year":"2009","journal-title":"J. Leukoc. Biol."},{"issue":"9","key":"10.1016\/j.bbi.2026.106283_b0295","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1111\/j.1365-2044.2008.05523.x","article-title":"Delirium is associated with early postoperative cognitive dysfunction","volume":"63","author":"Rudolph","year":"2008","journal-title":"Anaesthesia"},{"key":"10.1016\/j.bbi.2026.106283_b0300","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.jpsychires.2020.06.005","article-title":"Epigenetics of neuroinflammation: Immune response, inflammatory response and cholinergic synaptic involvement evidenced by genome-wide DNA methylation analysis of delirious inpatients","volume":"129","author":"Saito","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbi.2026.106283_b0305","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbi.2017.01.010","article-title":"Pathophysiological and behavioral effects of systemic inflammation in aged and diseased rodents with relevance to delirium: a systematic review","volume":"62","author":"Schreuder","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"10","key":"10.1016\/j.bbi.2026.106283_b0310","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.5603\/KP.a2017.0122","article-title":"Age- and gender-related peculiarities of patients with delirium in the cardiac intensive care unit","volume":"75","author":"Serpytis","year":"2017","journal-title":"Kardiol. Pol."},{"issue":"40","key":"10.1016\/j.bbi.2026.106283_b0315","doi-asserted-by":"crossref","first-page":"42504","DOI":"10.18632\/oncotarget.6391","article-title":"Genome-wide haplotype association study identify TNFRSF1A, CASP7, LRP1B, CDH1 and TG genes associated with Alzheimer's disease in Caribbean hispanic individuals","volume":"6","author":"Shang","year":"2015","journal-title":"Oncotarget"},{"issue":"5","key":"10.1016\/j.bbi.2026.106283_b0320","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1016\/j.wneu.2015.05.057","article-title":"Risk factors for delirium after spinal surgery: a meta-analysis","volume":"84","author":"Shi","year":"2015","journal-title":"World Neurosurg."},{"issue":"5","key":"10.1016\/j.bbi.2026.106283_b0325","doi-asserted-by":"crossref","first-page":"1060","DOI":"10.1002\/ajmg.b.31078","article-title":"Genetic pathway-based hierarchical clustering analysis of older adults with cognitive complaints and amnestic mild cognitive impairment using clinical and neuroimaging phenotypes","volume":"153B","author":"Sloan","year":"2010","journal-title":"Am. J. Med. Genet. B Neuropsychiatr. Genet."},{"key":"10.1016\/j.bbi.2026.106283_b0330","doi-asserted-by":"crossref","first-page":"243","DOI":"10.3389\/fnmol.2017.00243","article-title":"Chromatin Remodeling BAF (SWI\/SNF) complexes in neural development and disorders","volume":"10","author":"Sokpor","year":"2017","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbi.2026.106283_b0335","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.665935","article-title":"Integrative analysis of lncRNA and mRNA and profiles in postoperative delirium patients","volume":"13","author":"Song","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"9","key":"10.1016\/j.bbi.2026.106283_b0340","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1097\/EJA.0000000000001456","article-title":"Physostigmine for prevention of postoperative delirium and long-term cognitive dysfunction in liver surgery: a double-blinded randomised controlled trial","volume":"38","author":"Spies","year":"2021","journal-title":"Eur. J. Anaesthesiol."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0345","doi-asserted-by":"crossref","first-page":"548","DOI":"10.1097\/ALN.0b013e318195b569","article-title":"Long-term consequences of postoperative cognitive dysfunction","volume":"110","author":"Steinmetz","year":"2009","journal-title":"Anesthesiology"},{"issue":"Pt B","key":"10.1016\/j.bbi.2026.106283_b0350","article-title":"Recent advances in studies of 15-PGDH as a key enzyme for the degradation of prostaglandins","volume":"101","author":"Sun","year":"2021","journal-title":"Int. Immunopharmacol."},{"issue":"6","key":"10.1016\/j.bbi.2026.106283_b0355","doi-asserted-by":"crossref","first-page":"1881","DOI":"10.1097\/CCM.0b013e3181a00118","article-title":"Comparison of delirium assessment tools in a mixed intensive care unit","volume":"37","author":"van Eijk","year":"2009","journal-title":"Crit. Care Med."},{"issue":"9716","key":"10.1016\/j.bbi.2026.106283_b0360","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/S0140-6736(09)61158-2","article-title":"Systemic infection and delirium: when cytokines and acetylcholine collide","volume":"375","author":"van Gool","year":"2010","journal-title":"Lancet"},{"issue":"4","key":"10.1016\/j.bbi.2026.106283_b0365","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1089\/rej.2011.1155","article-title":"Genetic variations in the interleukin-6 and interleukin-8 genes and the interleukin-6 receptor gene in delirium","volume":"14","author":"van Munster","year":"2011","journal-title":"Rejuvenation Res."},{"issue":"10","key":"10.1016\/j.bbi.2026.106283_b0370","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1111\/anae.15469","article-title":"The effect of peri-operative dexmedetomidine on the incidence of postoperative delirium in cardiac and non-cardiac surgical patients: a randomised, double-blind placebo-controlled trial","volume":"76","author":"van Norden","year":"2021","journal-title":"Anaesthesia"},{"issue":"12","key":"10.1016\/j.bbi.2026.106283_b0375","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1159\/000533789","article-title":"Application of multiple omics to understand postoperative delirium pathophysiology in humans","volume":"69","author":"Vasunilashorn","year":"2023","journal-title":"Gerontology"},{"key":"10.1016\/j.bbi.2026.106283_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105266","article-title":"Emerging role of ficolins in autoimmune diseases","volume":"163","author":"Wang","year":"2021","journal-title":"Pharmacol. Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.106283_b0385","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41398-021-01304-y","article-title":"Neurocognitive disorders in the elderly: altered functional resting-state hyperconnectivities in postoperative delirium patients","volume":"11","author":"Winterer","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106283_b0390","unstructured":"World report on Ageing and Health. Geneva, Switzerland: World Health Organisation; 2015 2015."},{"issue":"468","key":"10.1016\/j.bbi.2026.106283_b0395","doi-asserted-by":"crossref","first-page":"909","DOI":"10.1198\/016214504000000683","article-title":"A model-based background adjustment for oligonucleotide expression arrays","volume":"99","author":"Wu","year":"2004","journal-title":"J. Am. Stat. Assoc."},{"issue":"1","key":"10.1016\/j.bbi.2026.106283_b0400","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1083\/jcb.201110023","article-title":"Structural specializations of alpha(4)beta(7), an integrin that mediates rolling adhesion","volume":"196","author":"Yu","year":"2012","journal-title":"J. Cell Biol."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0405","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2022-066709","article-title":"Quality contract 'prevention of postoperative delirium in the care of elderly patients' study protocol: a non-randomised, pre-post, monocentric, prospective trial","volume":"13","author":"Yurek","year":"2023","journal-title":"BMJ Open"},{"issue":"11","key":"10.1016\/j.bbi.2026.106283_b0410","doi-asserted-by":"crossref","first-page":"6899","DOI":"10.4049\/jimmunol.1001225","article-title":"Secreted M-ficolin anchors onto monocyte transmembrane G protein-coupled receptor 43 and cross talks with plasma C-reactive protein to mediate immune signaling and regulate host defense","volume":"185","author":"Zhang","year":"2010","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.bbi.2026.106283_b0415","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1016\/j.jalz.2018.10.005","article-title":"A rare missense variant of CASP7 is associated with familial late-onset Alzheimer's disease","volume":"15","author":"Zhang","year":"2019","journal-title":"Alzheimers Dement."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126000310?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126000310?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,4,9]],"date-time":"2026-04-09T16:05:04Z","timestamp":1775750704000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126000310"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,5]]},"references-count":83,"alternative-id":["S0889159126000310"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106283","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Altered gene expression associated with postoperative delirium in patients undergoing surgery and anesthesia","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106283","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106283"}}