{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,28]],"date-time":"2026-08-28T02:04:33Z","timestamp":1787882673733,"version":"build-2784847793"},"reference-count":33,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2016HQ14"],"award-info":[{"award-number":["ZR2016HQ14"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Natural Science Foundation of Shandong Province","doi-asserted-by":"publisher","award":["ZR2021MH135"],"award-info":[{"award-number":["ZR2021MH135"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007322","name":"Binzhou Medical University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007322","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81601108"],"award-info":[{"award-number":["81601108"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbi.2026.106510","type":"journal-article","created":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T06:50:21Z","timestamp":1772347821000},"page":"106510","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Lnc-USP28-6\/ZBTB16 axis orchestrates NLRP3 inflammasome activation and \u03b1-synuclein SUMOylation to drive Parkinson\u2019s disease pathogenesis"],"prefix":"10.1016","volume":"135","author":[{"given":"Nan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yifei","family":"You","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiajia","family":"An","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Jia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bin","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhang","family":"Cao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianzhi","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruli","family":"Ge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chen","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongcai","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.106510_b0005","doi-asserted-by":"crossref","first-page":"8465","DOI":"10.1038\/s41467-023-43945-1","article-title":"Inflammasome activity is controlled by ZBTB16-dependent SUMOylation of ASC","volume":"14","author":"Dong","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2026.106510_b0010","doi-asserted-by":"crossref","DOI":"10.1016\/j.gene.2024.148691","article-title":"ZBTB16 as potential biomarkers mediate the inflammatory response in keratoconjunctivitis sicca","volume":"927","author":"Dong","year":"2024","journal-title":"Gene"},{"key":"10.1016\/j.bbi.2026.106510_b0015","doi-asserted-by":"crossref","first-page":"1317","DOI":"10.2217\/epi-2017-0062","article-title":"The emerging molecular biology toolbox for the study of long noncoding RNA biology","volume":"9","author":"Fok","year":"2017","journal-title":"Epigenomics"},{"key":"10.1016\/j.bbi.2026.106510_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.1001676","article-title":"PLZF regulates fibroblast growth factor responsiveness and maintenance of neural progenitors","volume":"11","author":"Gaber","year":"2013","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbi.2026.106510_b0025","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.878771","article-title":"Neuroinflammation in Parkinson\u2019s Disease - putative pathomechanisms and targets for disease-modification","volume":"13","author":"Grotemeyer","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106510_b0030","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.763323","article-title":"Parkinson\u2019s disease is associated with dysregulation of circulatory levels of lncRNAs","volume":"12","author":"Honarmand Tamizkar","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106510_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2024.e38822","article-title":"SHANK2-AS3: a potential biomarker for Parkinson\u2019s disease and its role in neuronal apoptosis via NF-\u03baB signaling in SH-SY5Y cells","volume":"10","author":"Huang","year":"2024","journal-title":"Heliyon"},{"key":"10.1016\/j.bbi.2026.106510_b0040","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2023.115735","article-title":"The interplay between \u03b1-Synuclein and NLRP3 inflammasome in Parkinson's disease","volume":"168","author":"Huang","year":"2023","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbi.2026.106510_b0045","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.brainres.2019.01.041","article-title":"Altered expression of dopaminergic cell fate regulating genes prior to manifestation of symptoms in a transgenic rat model of Huntington\u2019s disease","volume":"1712","author":"Huguet","year":"2019","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2026.106510_b0050","doi-asserted-by":"crossref","first-page":"281","DOI":"10.37349\/ent.2023.00052","article-title":"The effects of post-translational modifications on alpha-synuclein aggregation and immune cell activation in Parkinson\u2019s disease","volume":"3","author":"Khan","year":"2023","journal-title":"Explor. Neuroprot. Ther."},{"key":"10.1016\/j.bbi.2026.106510_b0055","doi-asserted-by":"crossref","first-page":"S106","DOI":"10.5213\/inj.2244254.127","article-title":"Striatal ZBTB16 is associated with cognitive deficits in alzheimer disease mice","volume":"26","author":"Lee","year":"2022","journal-title":"Int. Neurourol. J."},{"key":"10.1016\/j.bbi.2026.106510_b0060","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1007\/s12035-012-8267-8","article-title":"Inflammation and \u03b1-synuclein\u2019s prion-like behavior in Parkinson\u2019s disease\u2013is there a link?","volume":"47","author":"Lema Tom\u00e9","year":"2013","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106510_b0065","doi-asserted-by":"crossref","first-page":"744","DOI":"10.3389\/fgene.2018.00744","article-title":"Long non-coding RNA in neuronal development and neurological disorders","volume":"9","author":"Li","year":"2019","journal-title":"Front. Genet."},{"key":"10.1016\/j.bbi.2026.106510_b0070","doi-asserted-by":"crossref","unstructured":"Liu, Y. L., Wang, R., Sun, F. J., Wang, N., Wang, M. D., Cai, J. F., Zhao, B., Zhang, Q. Q., Ge, R. L., Wang, H. C., 2025. Stereotactic infusion of rotenone into the SN induced a late-stage model of Parkinson's disease. Exp. Neurol. 393. https:\/\/doi.org\/ 10.1016\/j.expneurol.2025.115382.","DOI":"10.1016\/j.expneurol.2025.115382"},{"key":"10.1016\/j.bbi.2026.106510_b0075","doi-asserted-by":"crossref","unstructured":"Liu, W. J., Lu, Y. Q., Liu, J., Yu, Y., Yang, H., 2025. Bridging the gap: investigating the role of phosphorylation at the serine 129 site of \u03b1-synuclein in VAPB-PTPIP51 interactions. acta neuropathol commun. 13, 40. https:\/\/doi.org\/10.1186\/s40478-025-01949-6.","DOI":"10.1186\/s40478-025-01949-6"},{"key":"10.1016\/j.bbi.2026.106510_b0080","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1002\/stem.2270","article-title":"Concise review: balancing stem cell self-renewal and differentiation with PLZF","volume":"34","author":"Liu","year":"2016","journal-title":"Stem Cells"},{"key":"10.1016\/j.bbi.2026.106510_b0085","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aao2110","article-title":"How do lncRNAs regulate transcription?","volume":"3","author":"Long","year":"2017","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbi.2026.106510_b0090","doi-asserted-by":"crossref","first-page":"7602","DOI":"10.1073\/pnas.1601504113","article-title":"Multiple layers of transcriptional regulation by PLZF in NKT-cell development","volume":"113","author":"Mao","year":"2016","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2026.106510_b0095","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1038\/s41467-017-00882-0","article-title":"A shared Runx1-bound Zbtb16 enhancer directs innate and innate-like lymphoid lineage development","volume":"8","author":"Mao","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2026.106510_b0100","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0157852","article-title":"Gene expression differences in peripheral blood of Parkinson\u2019s disease patients with distinct progression profiles","volume":"11","author":"Pinho","year":"2016","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2026.106510_b0105","doi-asserted-by":"crossref","first-page":"17013","DOI":"10.1038\/nrdp.2017.13","article-title":"Parkinson disease","volume":"3","author":"Poewe","year":"2017","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbi.2026.106510_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2021.173914","article-title":"Assessment of the role of non-coding RNAs in the pathophysiology of Parkinson\u2019s disease","volume":"896","author":"Rezaei","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106510_b0115","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0130416","article-title":"NLRP7, involved in hydatidiform molar pregnancy (HYDM1), interacts with the transcriptional repressor ZBTB16","volume":"10","author":"Singer","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2026.106510_b0120","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/s12974-022-02565-0","article-title":"Astrocytic and microglial cells as the modulators of neuroinflammation in Alzheimer\u2019s disease","volume":"19","author":"Singh","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106510_b0125","doi-asserted-by":"crossref","first-page":"74","DOI":"10.3389\/fonc.2012.00074","article-title":"The promyelocytic leukemia zinc finger protein: two decades of molecular oncology","volume":"2","author":"Suliman","year":"2012","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbi.2026.106510_b0130","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/s41398-021-01358-y","article-title":"Zbtb16 regulates social cognitive behaviors and neocortical development","volume":"11","author":"Usui","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106510_b0135","doi-asserted-by":"crossref","first-page":"86","DOI":"10.3390\/ijms22010086","article-title":"Long Non-coding RNAs, the dark matter: an emerging regulatory component in plants","volume":"22","author":"Waseem","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106510_b0140","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1007\/s11064-021-03230-3","article-title":"Long Non-coding RNAs in Parkinson\u2019s disease","volume":"46","author":"Xin","year":"2021","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbi.2026.106510_b0145","doi-asserted-by":"crossref","first-page":"276","DOI":"10.3892\/etm.2023.11975","article-title":"ZBTB16 eases lipopolysaccharide\u2013elicited inflammation, apoptosis and degradation of extracellular matrix in chondrocytes during osteoarthritis by suppressing GRK2 transcription","volume":"25","author":"Xiong","year":"2023","journal-title":"Exp. Ther. Med."},{"key":"10.1016\/j.bbi.2026.106510_b0150","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1038\/s41598-022-06539-3","article-title":"Significant modulations of linc001128 and linc0938 with miR-24-3p and miR-30c-5p in Parkinson disease","volume":"12","author":"Yousefi","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2026.106510_b0155","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.06734","article-title":"G-protein-coupled receptors regulate autophagy by ZBTB16-mediated ubiquitination and proteasomal degradation of Atg14L","volume":"4","author":"Zhang","year":"2015","journal-title":"Elife"},{"key":"10.1016\/j.bbi.2026.106510_b0160","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.bbi.2024.03.038","article-title":"Pyroptosis-mediator GSDMD promotes Parkinson\u2019s disease pathology via microglial activation and dopaminergic neuronal death","volume":"119","author":"Zhang","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2026.106510_b0165","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41593-022-01239-7","article-title":"Post-translational modifications of soluble \u03b1-synuclein regulate the amplification of pathological \u03b1-synuclein","volume":"26","author":"Zhang","year":"2023","journal-title":"Nat. Neurosci."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126002588?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126002588?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:31:40Z","timestamp":1781062300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126002588"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":33,"alternative-id":["S0889159126002588"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106510","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lnc-USP28-6\/ZBTB16 axis orchestrates NLRP3 inflammasome activation and \u03b1-synuclein SUMOylation to drive Parkinson\u2019s disease pathogenesis","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106510","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106510"}}