{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,28]],"date-time":"2026-07-28T14:13:32Z","timestamp":1785248012245,"version":"3.55.0"},"reference-count":99,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T00:00:00Z","timestamp":1772668800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA057884"],"award-info":[{"award-number":["R01DA057884"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01DA057145"],"award-info":[{"award-number":["R01DA057145"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbi.2026.106528","type":"journal-article","created":{"date-parts":[[2026,3,4]],"date-time":"2026-03-04T00:17:22Z","timestamp":1772583442000},"page":"106528","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["The role of NLRP3 inflammasome in opioid-induced neurochemical markers, therapeutic effects, and adverse effects in male mice"],"prefix":"10.1016","volume":"135","author":[{"given":"Myosotys","family":"Rodriguez","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dileepkumar","family":"Veeragoni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Candy","family":"Carbajal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Florida","family":"Owens","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shainnel O.","family":"Eans","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashai K.","family":"Williams","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryosuke","family":"Shinouchi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jay P.","family":"McLaughlin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8154-6763","authenticated-orcid":false,"given":"Nazira","family":"El-Hage","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.106528_b0005","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1097\/ALN.0b013e318238bba6","article-title":"Molecular mechanisms of opioid receptor-dependent signaling and behavior","volume":"115","author":"Al-Hasani","year":"2011","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbi.2026.106528_b0010","doi-asserted-by":"crossref","DOI":"10.3390\/v15020415","article-title":"Virally suppressed People living with HIV who use opioids have diminished latency reversal","volume":"15","author":"Basukala","year":"2023","journal-title":"Viruses"},{"key":"10.1016\/j.bbi.2026.106528_b0015","doi-asserted-by":"crossref","first-page":"799","DOI":"10.1016\/j.jpain.2012.05.005","article-title":"Differential development of antinociceptive tolerance to morphine and fentanyl is not linked to efficacy in the ventrolateral periaqueductal gray of the rat","volume":"13","author":"Bobeck","year":"2012","journal-title":"J. Pain"},{"key":"10.1016\/j.bbi.2026.106528_b0020","doi-asserted-by":"crossref","first-page":"4209","DOI":"10.1111\/bph.15165","article-title":"Multifunctional opioid receptor agonism and antagonism by a novel macrocyclic tetrapeptide prevents reinstatement of morphine-seeking behaviour","volume":"177","author":"Brice-Tutt","year":"2020","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106528_b0025","article-title":"Morphine and fentanyl repeated administration induces different levels of NLRP3-dependent pyroptosis in the dorsal raphe nucleus of male rats via cell-specific activation of TLR4 and opioid receptors","author":"Carranza-Aguilar","year":"2020","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106528_b0030","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1007\/s10571-020-00957-5","article-title":"Morphine and fentanyl repeated administration induces different levels of NLRP3-dependent pyroptosis in the dorsal raphe nucleus of male rats via cell-specific activation of TLR4 and opioid receptors","volume":"42","author":"Carranza-Aguilar","year":"2022","journal-title":"Cell. Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106528_b0035","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1472-8206.1995.tb00517.x","article-title":"Opioid and anti-opioid peptides","volume":"9","author":"Cesselin","year":"1995","journal-title":"Fundam. Clin. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106528_b0040","article-title":"The roles of c-Jun N-terminal kinase (JNK) in Infectious Diseases","volume":"22","author":"Chen","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106528_b0045","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1186\/s12974-021-02131-0","article-title":"The NLRP3 inflammasome: an emerging therapeutic target for chronic pain","volume":"18","author":"Chen","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106528_b0050","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2019.104339","article-title":"Pharmacological inhibition of the NLRP3 inflammasome as a potential target for cancer-induced bone pain","volume":"147","author":"Chen","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbi.2026.106528_b0055","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/0896-6273(92)90245-9","article-title":"The rat brain postsynaptic density fraction contains a homolog of the drosophila discs-large tumor suppressor protein","volume":"9","author":"Cho","year":"1992","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2026.106528_b0060","doi-asserted-by":"crossref","first-page":"1906","DOI":"10.1002\/glia.24374","article-title":"Focal mu-opioid receptor activation promotes neuroinflammation and microglial activation in the mesocorticolimbic system: Alterations induced by inflammatory pain","volume":"71","author":"Cuitavi","year":"2023","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2026.106528_b0065","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1038\/mt.2011.42","article-title":"Perturbing PSD-95 interactions with NR2B-subtype receptors attenuates spinal nociceptive plasticity and neuropathic pain","volume":"19","author":"D'Mello","year":"2011","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbi.2026.106528_b0070","first-page":"10","article-title":"The role of opioid receptors in immune system function","author":"Eisenstein","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106528_b0075","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/glia.20148","article-title":"Synergistic increases in intracellular Ca2+, and the release of MCP-1, RANTES, and IL-6 by astrocytes treated with opiates and HIV-1 Tat","volume":"50","author":"El-Hage","year":"2005","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2026.106528_b0080","doi-asserted-by":"crossref","first-page":"e4093","DOI":"10.1371\/journal.pone.0004093","article-title":"Morphine exacerbates HIV-1 Tat-induced cytokine production in astrocytes through convergent effects on [Ca(2+)](i), NF-kappaB trafficking and transcription","volume":"3","author":"El-Hage","year":"2008","journal-title":"Plos One"},{"key":"10.1016\/j.bbi.2026.106528_b0085","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s11481-008-9127-1","article-title":"CCL5\/RANTES gene deletion attenuates opioid-induced increases in glial CCL2\/MCP-1 immunoreactivity and activation in HIV-1 Tat-exposed mice","volume":"3","author":"El-Hage","year":"2008","journal-title":"J. Neuroimmune Pharmacol."},{"key":"10.1016\/j.bbi.2026.106528_b0090","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.bbi.2016.08.004","article-title":"Morphine amplifies mechanical allodynia via TLR4 in a rat model of spinal cord injury","volume":"58","author":"Ellis","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106528_b0095","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1016\/j.jpain.2005.02.003","article-title":"Effects of N-methyl-D-aspartate receptor antagonists on acute morphine-induced and l-methadone-induced antinociception in mice","volume":"6","author":"Fischer","year":"2005","journal-title":"J. Pain"},{"key":"10.1016\/j.bbi.2026.106528_b0100","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1111\/j.1600-065X.2008.00734.x","article-title":"Function of Nod-like receptors in microbial recognition and host defense","volume":"227","author":"Franchi","year":"2009","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbi.2026.106528_b0105","doi-asserted-by":"crossref","DOI":"10.3390\/v13081472","article-title":"Buprenorphine increases HIV-1 infection in vitro but does not reactivate HIV-1 from latency","volume":"13","author":"Gornalusse","year":"2021","journal-title":"Viruses"},{"key":"10.1016\/j.bbi.2026.106528_b0110","doi-asserted-by":"crossref","first-page":"E3441","DOI":"10.1073\/pnas.1602070113","article-title":"Morphine paradoxically prolongs neuropathic pain in rats by amplifying spinal NLRP3 inflammasome activation","volume":"113","author":"Grace","year":"2016","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2026.106528_b0120","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/j.1600-065X.2011.01046.x","article-title":"The inflammasome: an integrated view","volume":"243","author":"Gross","year":"2011","journal-title":"Immunol. Rev."},{"key":"10.1016\/j.bbi.2026.106528_b0125","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1038\/nm.3893","article-title":"Inflammasomes: mechanism of action, role in disease, and therapeutics","volume":"21","author":"Guo","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2026.106528_b9000","series-title":"NLRP3 inflammasome is involved in cocaine-mediated potentiation on behavioral changes in CX3CR1-deficient mice","first-page":"11","author":"Guo","year":"2021"},{"key":"10.1016\/j.bbi.2026.106528_b0135","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0006-8993(96)00103-5","article-title":"mu-Opioid receptor-induced Ca2+ mobilization and astroglial development: morphine inhibits DNA synthesis and stimulates cellular hypertrophy through a Ca(2+)-dependent mechanism","volume":"720","author":"Hauser","year":"1996","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2026.106528_b0145","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1097\/FBP.0b013e32835f3d2f","article-title":"Inhibition of G\u03b2\u03b3-subunit signaling potentiates morphine-induced antinociception but not respiratory depression, constipation, locomotion, and reward","volume":"24","author":"Hoot","year":"2013","journal-title":"Behav. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106528_b0150","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.neuron.2013.10.025","article-title":"AMPARs and synaptic plasticity: the last 25 Years","volume":"80","author":"Huganir Richard","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2026.106528_b0155","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.neuroscience.2010.02.011","article-title":"Possible involvement of toll-like receptor 4\/myeloid differentiation factor-2 activity of opioid inactive isomers causes spinal proinflammation and related behavioral consequences","volume":"167","author":"Hutchinson","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2026.106528_b0160","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1124\/pr.110.004135","article-title":"Exploring the neuroimmunopharmacology of opioids: an integrative review of mechanisms of central immune signaling and their implications for opioid analgesia","volume":"63","author":"Hutchinson","year":"2011","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbi.2026.106528_b0165","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1146\/annurev.neuro.29.051605.113009","article-title":"Neural mechanisms of addiction: the role of reward-related learning and memory","volume":"29","author":"Hyman","year":"2006","journal-title":"Annu. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2026.106528_b0170","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12974-017-0980-9","article-title":"Targeting the NLRP3 inflammasome to attenuate spinal cord injury in mice","volume":"14","author":"Jiang","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106528_b0175","doi-asserted-by":"crossref","first-page":"680","DOI":"10.1016\/S0022-3565(25)09535-7","article-title":"Preventing morphine antinociceptive tolerance by irreversible mu opioid antagonists before the onset of their antagonism","volume":"273","author":"Jiang","year":"1995","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2026.106528_b0180","doi-asserted-by":"crossref","first-page":"37","DOI":"10.3389\/fmolb.2020.00037","article-title":"MCC950, a selective inhibitor of NLRP3 inflammasome, reduces the inflammatory response and improves neurological outcomes in mice model of spinal cord injury","volume":"7","author":"Jiao","year":"2020","journal-title":"Front. Mol. Biosci."},{"key":"10.1016\/j.bbi.2026.106528_b0185","doi-asserted-by":"crossref","first-page":"8903","DOI":"10.1021\/jm500989n","article-title":"Nonpeptide small molecule agonist and antagonist original leads for neuropeptide FF1 and FF2 receptors","volume":"57","author":"Journigan","year":"2014","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbi.2026.106528_b0190","doi-asserted-by":"crossref","first-page":"15304","DOI":"10.1523\/JNEUROSCI.4255-10.2010","article-title":"Morphine induces AMPA receptor internalization in primary hippocampal neurons via calcineurin-dependent dephosphorylation of GluR1 subunits","volume":"30","author":"Kam","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106528_b0195","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1038\/nrn2234","article-title":"Synaptic plasticity and addiction","volume":"8","author":"Kauer","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2026.106528_b0200","doi-asserted-by":"crossref","DOI":"10.3390\/ijms20133328","article-title":"The NLRP3 inflammasome: an overview of mechanisms of activation and regulation","volume":"20","author":"Kelley","year":"2019","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106528_b0205","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1111\/dar.14093","article-title":"Fentanyl polysubstance use patterns and their associations with hepatitis C virus, skin and soft tissue infections, and non-fatal overdose among people who inject drugs in New York City","volume":"44","author":"Khezri","year":"2025","journal-title":"Drug Alcohol Rev."},{"key":"10.1016\/j.bbi.2026.106528_b0210","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1093\/infdis\/jiaa634","article-title":"Nonstructured treatment interruptions are associated with higher human immunodeficiency virus reservoir size measured by intact proviral DNA assay in people who inject drugs","volume":"223","author":"Kirk","year":"2021","journal-title":"J Infect Dis"},{"key":"10.1016\/j.bbi.2026.106528_b0215","doi-asserted-by":"crossref","first-page":"1737","DOI":"10.1126\/science.7569905","article-title":"Domain interaction between NMDA receptor subunits and the postsynaptic density protein PSD-95","volume":"269","author":"Kornau","year":"1995","journal-title":"Science"},{"key":"10.1016\/j.bbi.2026.106528_b0220","doi-asserted-by":"crossref","first-page":"1013","DOI":"10.1016\/j.cell.2014.04.007","article-title":"Mechanisms and functions of inflammasomes","volume":"157","author":"Lamkanfi","year":"2014","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2026.106528_b0225","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1038\/nri3452","article-title":"Activation and regulation of the inflammasomes","volume":"13","author":"Latz","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2026.106528_b0230","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a001651","article-title":"The nuclear factor NF-kappaB pathway in inflammation","volume":"1","author":"Lawrence","year":"2009","journal-title":"Cold Spring Harb. Perspect. Biol."},{"key":"10.1016\/j.bbi.2026.106528_b0235","first-page":"11","article-title":"Monitoring and modulating inflammation-associated alterations in synaptic plasticity: role of brain stimulation and the blood-brain interface","author":"Lenz","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbi.2026.106528_b9005","article-title":"NLRP3-mediated neuroinflammation in the ventrolateral orbital cortex contributes to the formation of morphine-induced addiction memory by upregulating GRIN3B","volume":"257","author":"Liu","year":"2025","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106528_b0245","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1007\/s12031-022-01989-w","article-title":"Blocking of caveolin-1 attenuates morphine-induced inflammation, hyperalgesia, and analgesic tolerance via inhibiting NLRP3 inflammasome and ERK\/c-JUN pathway","volume":"72","author":"Liu","year":"2022","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbi.2026.106528_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2020.101560","article-title":"Melatonin alleviates morphine analgesic tolerance in mice by decreasing NLRP3 inflammasome activation","volume":"34","author":"Liu","year":"2020","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbi.2026.106528_b0255","doi-asserted-by":"crossref","first-page":"16046","DOI":"10.1038\/sigtrans.2016.46","article-title":"Erratum: USP21 deubiquitylates Nanog to regulate protein stability and stem cell pluripotency","volume":"2","author":"Liu","year":"2017","journal-title":"Signal Transduct. Target. Ther."},{"key":"10.1016\/j.bbi.2026.106528_b0260","doi-asserted-by":"crossref","first-page":"886","DOI":"10.3389\/fnins.2018.00886","article-title":"The Contribution of the Descending Pain Modulatory Pathway in Opioid Tolerance","volume":"12","author":"Lueptow","year":"2018","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbi.2026.106528_b0270","doi-asserted-by":"crossref","first-page":"2273","DOI":"10.1093\/brain\/awx133","article-title":"Inflammasomes in neurological diseases: emerging pathogenic and therapeutic concepts","volume":"140","author":"Mamik","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2026.106528_b0275","doi-asserted-by":"crossref","first-page":"7731","DOI":"10.1073\/pnas.96.14.7731","article-title":"Cellular mechanisms of neuropathic pain, morphine tolerance, and their interactions","volume":"96","author":"Mayer","year":"1999","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2026.106528_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugpo.2023.104063","article-title":"Understanding intentionality of fentanyl use and drug overdose risk: Findings from a mixed methods study of people who inject drugs in New York City","volume":"118","author":"McKnight","year":"2023","journal-title":"Int. J. Drug Policy"},{"issue":"103","key":"10.1016\/j.bbi.2026.106528_b0285","first-page":"45","article-title":"Prescription opioid prescribing in western Europe and the United States","volume":"2013","author":"Meyer","year":"2020","journal-title":"R I Med. J."},{"key":"10.1016\/j.bbi.2026.106528_b0290","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.toxlet.2012.12.021","article-title":"Comparison of tolerance to morphine-induced respiratory and analgesic effects in mice","volume":"217","author":"Mohammed","year":"2013","journal-title":"Toxicol. Lett."},{"key":"10.1016\/j.bbi.2026.106528_b0295","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.bbi.2014.06.011","article-title":"Dissociation of immunosuppressive and nociceptive effects of fentanyl, but not morphine, after repeated administration in mice: Fentanyl-induced sensitization to LPS","volume":"42","author":"Molina-Mart\u00ednez","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106528_b0300","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/j.jhep.2017.01.022","article-title":"NLRP3 inflammasome blockade reduces liver inflammation and fibrosis in experimental NASH in mice","volume":"66","author":"Mridha","year":"2017","journal-title":"J. Hepatol."},{"key":"10.1016\/j.bbi.2026.106528_b0305","doi-asserted-by":"crossref","DOI":"10.1002\/14651858.CD006605.pub2","article-title":"Long-term opioid management for chronic noncancer pain","author":"Noble","year":"2010","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbi.2026.106528_b0310","doi-asserted-by":"crossref","first-page":"5119","DOI":"10.1021\/acs.jmedchem.9b01924","article-title":"Preventing morphine-seeking behavior through the re-engineering of vincamine's biological activity","volume":"63","author":"Norwood","year":"2020","journal-title":"J. Med. Chem."},{"key":"10.1016\/j.bbi.2026.106528_b0315","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1038\/s41586-024-07587-7","article-title":"A micro-opioid receptor modulator that works cooperatively with naloxone","volume":"631","author":"O'Brien","year":"2024","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2026.106528_b0320","doi-asserted-by":"crossref","first-page":"1490","DOI":"10.1021\/acscentsci.4c00525","article-title":"Signaling Modulation Mediated by Ligand Water Interactions with the Sodium Site at \u03bcOR","volume":"10","author":"Ople","year":"2024","journal-title":"ACS Cent. Sci."},{"key":"10.1016\/j.bbi.2026.106528_b0325","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.freeradbiomed.2023.12.023","article-title":"Blocking \u03bc-opioid receptor by naltrexone exaggerates oxidative stress and airway inflammation via the MAPkinase pathway in a murine model of asthma","volume":"212","author":"Pandey","year":"2024","journal-title":"Free Radic. Biol. Med."},{"key":"10.1016\/j.bbi.2026.106528_b0330","doi-asserted-by":"crossref","first-page":"8618","DOI":"10.1038\/s41598-018-26775-w","article-title":"MCC950, a specific small molecule inhibitor of NLRP3 inflammasome attenuates colonic inflammation in spontaneous colitis mice","volume":"8","author":"Perera","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2026.106528_b0335","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1007\/s003930170003","article-title":"Nociception, pain, and antinociception: current concepts","volume":"60","author":"Riedel","year":"2001","journal-title":"Z. Rheumatol."},{"key":"10.1016\/j.bbi.2026.106528_b0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0138583","article-title":"PD98059 influences immune factors and enhances opioid analgesia in model of neuropathy","volume":"10","author":"Rojewska","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2026.106528_b0345","doi-asserted-by":"crossref","first-page":"5748","DOI":"10.1523\/JNEUROSCI.2875-12.2016","article-title":"Nucleus Accumbens AMPA Receptors are Necessary for Morphine-Withdrawal-Induced Negative-Affective States in Rats","volume":"36","author":"Russell","year":"2016","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106528_b0350","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2012.00288","article-title":"NLRP3-inflammasome activating DAMPs stimulate an inflammatory response in glia in the absence of priming which contributes to brain inflammation after injury","volume":"3","author":"Savage","year":"2012","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106528_b0355","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12987-017-0080-3","article-title":"The opioid epidemic: a central role for the blood brain barrier in opioid analgesia and abuse","volume":"14","author":"Schaefer","year":"2017","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.bbi.2026.106528_b0360","doi-asserted-by":"crossref","first-page":"262","DOI":"10.3389\/fphar.2015.00262","article-title":"NLRP3 inflammasome and its inhibitors: a review","volume":"6","author":"Shao","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106528_b0365","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1186\/gb-2007-8-2-206","article-title":"The homer family proteins","volume":"8","author":"Shiraishi-Yamaguchi","year":"2007","journal-title":"Genome Biol."},{"key":"10.1016\/j.bbi.2026.106528_b0370","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1002\/glia.22460","article-title":"Astrocytes are a neural target of morphine action via glucocorticoid receptor-dependent signaling","volume":"61","author":"Slezak","year":"2013","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2026.106528_b0375","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1038\/nrneurol.2017.101","article-title":"Peripheral neuropathies: long-term opioid therapy in neuropathy: benefit or harm?","volume":"13","author":"Sommer","year":"2017","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2026.106528_b0380","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1007\/s00213-010-1844-5","article-title":"Endogenous kappa-opioid mediation of stress-induced potentiation of ethanol-conditioned place preference and self-administration","volume":"210","author":"Sperling","year":"2010","journal-title":"Psychopharmacology"},{"key":"10.1016\/j.bbi.2026.106528_b0385","doi-asserted-by":"crossref","first-page":"6154","DOI":"10.4049\/jimmunol.171.11.6154","article-title":"Apoptosis-associated speck-like protein containing a caspase recruitment domain is a regulator of procaspase-1 activation","volume":"171","author":"Stehlik","year":"2003","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2026.106528_b0390","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/0165-3806(93)90207-Q","article-title":"Opiates selectively increase intracellular calcium in developing type-1 astrocytes: role of calcium in morphine-induced morphologic differentiation","volume":"76","author":"Stiene-Martin","year":"1993","journal-title":"Brain Res. Dev. Brain Res."},{"key":"10.1016\/j.bbi.2026.106528_b0395","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.drugalcdep.2016.11.033","article-title":"A review: Fentanyl and non-pharmaceutical fentanyls","volume":"171","author":"Suzuki","year":"2017","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.bbi.2026.106528_b0400","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1080\/02791072.2020.1850946","article-title":"Cognitive impairment among people who use heroin and fentanyl: findings from the miami adult studies on HIV (MASH) Cohort","volume":"53","author":"Tamargo","year":"2021","journal-title":"J. Psychoact. Drugs"},{"key":"10.1016\/j.bbi.2026.106528_b0405","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/S0022-3565(24)29505-7","article-title":"Unifying perspectives of the mechanisms underlying the development of tolerance and physical dependence to opioids","volume":"297","author":"Taylor","year":"2001","journal-title":"J. Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbi.2026.106528_b0410","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/S0896-6273(00)80440-7","article-title":"N-Terminal Palmitoylation of PSD-95 regulates association with cell membranes and interaction with K+ channel Kv1.4","volume":"20","author":"Topinka","year":"1998","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2026.106528_b0415","first-page":"e26","article-title":"Opioid Tolerance in critical Illness","volume":"380","author":"Vanjani","year":"2019","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2026.106528_b0420","doi-asserted-by":"crossref","first-page":"385","DOI":"10.4155\/fmc.13.215","article-title":"Fentanyl-related compounds and derivatives: current status and future prospects for pharmaceutical applications","volume":"6","author":"Vardanyan","year":"2014","journal-title":"Future Med. Chem."},{"key":"10.1016\/j.bbi.2026.106528_b0425","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1056\/NEJMra1507771","article-title":"Opioid Abuse in Chronic Pain-Misconceptions and Mitigation strategies","volume":"374","author":"Volkow","year":"2016","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbi.2026.106528_b0430","doi-asserted-by":"crossref","first-page":"1476","DOI":"10.1016\/j.bbamcr.2013.02.017","article-title":"Inhibition of c-Jun NH2-terminal kinase stimulates mu opioid receptor expression via p38 MAPK-mediated nuclear NF-\u03baB activation in neuronal and non-neuronal cells","volume":"1833","author":"Wagley","year":"2013","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbi.2026.106528_b0435","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/1742-4690-11-35","article-title":"Rapid inflammasome activation in microglia contributes to brain disease in HIV\/AIDS","volume":"11","author":"Walsh","year":"2014","journal-title":"Retrovirology"},{"key":"10.1016\/j.bbi.2026.106528_b0440","doi-asserted-by":"crossref","first-page":"2601","DOI":"10.3389\/fimmu.2019.02601","article-title":"Morphine withdrawal enhances HIV infection of macrophages","volume":"10","author":"Wang","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106528_b0445","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1744-8069-6-5","article-title":"Regulation of AMPA receptors in spinal nociception","volume":"6","author":"Wang","year":"2010","journal-title":"Mol. Pain"},{"key":"10.1016\/j.bbi.2026.106528_b0450","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1016\/j.phrs.2019.01.035","article-title":"NLRP3 inflammasome inhibition with MCC950 improves diabetes-mediated cognitive impairment and vasoneuronal remodeling after ischemia","volume":"142","author":"Ward","year":"2019","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbi.2026.106528_b0455","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2020.108310","article-title":"Lyophilized kratom tea as a therapeutic option for opioid dependence","volume":"216","author":"Wilson","year":"2020","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.bbi.2026.106528_b0460","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1126\/science.288.5472.1765","article-title":"Neuronal plasticity: increasing the gain in pain","volume":"288","author":"Woolf","year":"2000","journal-title":"Science"},{"key":"10.1016\/j.bbi.2026.106528_b0465","doi-asserted-by":"crossref","first-page":"1449","DOI":"10.2174\/1381612824666180327165604","article-title":"Signaling pathways in inflammation and anti-inflammatory therapies","volume":"24","author":"Yeung","year":"2018","journal-title":"Curr. Pharm. Des."},{"key":"10.1016\/j.bbi.2026.106528_b0470","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1434295","article-title":"Effect of NLRP3 inflammasome induced astrocyte phenotype alteration in morphine tolerance","volume":"15","author":"Yuan","year":"2024","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106528_b0475","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1007\/s10787-023-01402-x","article-title":"NLRs and inflammasome signaling in opioid-induced hyperalgesia and tolerance","volume":"32","author":"Zare","year":"2024","journal-title":"Inflammopharmacology"},{"key":"10.1016\/j.bbi.2026.106528_b0480","doi-asserted-by":"crossref","first-page":"3063","DOI":"10.1007\/s12035-015-9203-5","article-title":"Activation and regulation of NLRP3 inflammasome by intrathecal application of SDF-1a in a spinal cord injury model","volume":"53","author":"Zendedel","year":"2016","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106528_b0485","doi-asserted-by":"crossref","first-page":"19305","DOI":"10.1038\/s41598-021-98437-3","article-title":"The selective NLRP3 inhibitor MCC950 hinders atherosclerosis development by attenuating inflammation and pyroptosis in macrophages","volume":"11","author":"Zeng","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2026.106528_b0490","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2021.112133","article-title":"MCC950 attenuates doxorubicin-induced myocardial injury in vivo and in vitro by inhibiting NLRP3-mediated pyroptosis","volume":"143","author":"Zhang","year":"2021","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbi.2026.106528_b0495","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1152\/jn.00526.2011","article-title":"Activity-dependent regulation of synaptic strength by PSD-95 in CA1 neurons","volume":"107","author":"Zhang","year":"2012","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbi.2026.106528_b0500","doi-asserted-by":"crossref","DOI":"10.1093\/ijnp\/pyv006","article-title":"NLRP3 inflammasome mediates chronic mild stress-induced depression in mice via neuroinflammation","volume":"18","author":"Zhang","year":"2015","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2026.106528_b0505","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1177\/1073858410386384","article-title":"MAGUKs, synaptic development, and synaptic plasticity","volume":"17","author":"Zheng","year":"2011","journal-title":"Neuroscientist"},{"key":"10.1016\/j.bbi.2026.106528_b0510","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.629891","article-title":"Enhanced autolysosomal function ameliorates the inflammatory response mediated by the NLRP3 inflammasome in Alzheimer's disease","volume":"13","author":"Zhou","year":"2021","journal-title":"Front. Aging Neurosci."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088915912600276X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S088915912600276X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T03:17:09Z","timestamp":1781061429000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S088915912600276X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":99,"alternative-id":["S088915912600276X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106528","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The role of NLRP3 inflammasome in opioid-induced neurochemical markers, therapeutic effects, and adverse effects in male mice","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106528","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106528"}}