{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:28:22Z","timestamp":1793608102479,"version":"4.5.0"},"reference-count":66,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100012173","name":"China-Japan Friendship Hospital","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012173","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbi.2026.106567","type":"journal-article","created":{"date-parts":[[2026,3,28]],"date-time":"2026-03-28T00:42:13Z","timestamp":1774658533000},"page":"106567","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Dorsal root ganglion macrophages mediate osteoarthritis pain via disruption of sensory neuron perineuronal nets"],"prefix":"10.1016","volume":"136","author":[{"given":"Fengrun","family":"Sun","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaofen","family":"Tian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ning","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huamei","family":"Cai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ziqi","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Peng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1346-6961","authenticated-orcid":false,"given":"Chao","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tao","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2013-7851","authenticated-orcid":false,"given":"Xiaowen","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.106567_b0005","doi-asserted-by":"crossref","DOI":"10.1016\/j.bcp.2024.116182","article-title":"Neuroinflammation in osteoarthritis: from pain to mood disorders","volume":"228","author":"Amodeo","year":"2024","journal-title":"Biochem. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106567_b0010","doi-asserted-by":"crossref","first-page":"2021","DOI":"10.1001\/jama.2021.19415","article-title":"Effect of Intra-articular Platelet-Rich Plasma vs Placebo Injection on Pain and Medial Tibial Cartilage volume in patients with knee Osteoarthritis: the RESTORE Randomized Clinical Trial","volume":"326","author":"Bennell","year":"2021","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbi.2026.106567_b0015","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1021\/acs.accounts.0c00864","article-title":"Strategy for Treatment of Infected Diabetic Foot Ulcers","volume":"54","author":"Chang","year":"2021","journal-title":"Acc. Chem. Res."},{"key":"10.1016\/j.bbi.2026.106567_b0020","doi-asserted-by":"crossref","first-page":"7651","DOI":"10.1038\/s41598-019-44172-9","article-title":"Adjacent intact nociceptive neurons drive the acute outburst of pain following peripheral axotomy","volume":"9","author":"Chen","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2026.106567_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2024.106614","article-title":"Phagocytosis of aggrecan-positive perineuronal nets surrounding motor neurons by reactive microglia expressing MMP-9 in TDP-43(Q331K) ALS model mice","volume":"200","author":"Cheung","year":"2024","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2026.106567_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.nbd.2025.106803","article-title":"Peripherally administered TNF inhibitor is not protective against \u03b1-synuclein-induced dopaminergic neuronal death in rats","volume":"206","author":"Christiansen","year":"2025","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2026.106567_b0035","doi-asserted-by":"crossref","first-page":"1397","DOI":"10.1016\/j.joca.2024.07.014","article-title":"Osteoarthritis year in review 2024: Epidemiology and therapy","volume":"32","author":"Courties","year":"2024","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bbi.2026.106567_b0040","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1016\/j.joca.2021.12.003","article-title":"Association between knee inflammation and knee pain in patients with knee osteoarthritis: a systematic review","volume":"30","author":"Dainese","year":"2022","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bbi.2026.106567_b0045","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1097\/j.pain.0000000000001879","article-title":"Regulatory T cells counteract neuropathic pain through inhibition of the Th1 response at the site of peripheral nerve injury","volume":"161","author":"Davoli-Ferreira","year":"2020","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2026.106567_b0050","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1097\/j.pain.0000000000003346","article-title":"Transient receptor potential melastatin 8 contributes to the interleukin-33-mediated cold allodynia in a mouse model of neuropathic pain","volume":"166","author":"Du","year":"2025","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2026.106567_b0055","doi-asserted-by":"crossref","DOI":"10.1172\/JCI153563","article-title":"A nerve injury-specific long noncoding RNA promotes neuropathic pain by increasing Ccl2 expression","volume":"132","author":"Du","year":"2022","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbi.2026.106567_b0060","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1038\/s41583-019-0196-3","article-title":"The roles of perineuronal nets and the perinodal extracellular matrix inneuronal function","volume":"20","author":"Fawcett","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2026.106567_b0065","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2215906120","article-title":"Self-renewing macrophages in dorsal root ganglia contribute to promote nerve regeneration","volume":"120","author":"Feng","year":"2023","journal-title":"PNAS"},{"key":"10.1016\/j.bbi.2026.106567_b0070","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1002\/glia.22722","article-title":"White matter injury: Ischemic and nonischemic","volume":"62","author":"Fern","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2026.106567_b0075","doi-asserted-by":"crossref","DOI":"10.1093\/rheumatology\/kex419","article-title":"Osteoarthritis: the genesis of pain","volume":"57","author":"Fu","year":"2018","journal-title":"Rheumatology (Oxford)"},{"key":"10.1016\/j.bbi.2026.106567_b0080","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1002\/art.42530","article-title":"Age-Associated changes in knee Osteoarthritis, Pain-Related Behaviors, and Dorsal root Ganglia Immunophenotyping of Male and Female mice","volume":"75","author":"Geraghty","year":"2023","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bbi.2026.106567_b0085","doi-asserted-by":"crossref","first-page":"e892","DOI":"10.1097\/PR9.0000000000000892","article-title":"Neuroimmune interactions and osteoarthritis pain: focus on macrophages","volume":"6","author":"Geraghty","year":"2021","journal-title":"Pain Reports"},{"key":"10.1016\/j.bbi.2026.106567_b0090","first-page":"376","volume":"386","author":"Glyn-Jones","year":"2015","journal-title":"Osteoarthritis. Lancet"},{"key":"10.1016\/j.bbi.2026.106567_b0095","doi-asserted-by":"crossref","first-page":"e1185","DOI":"10.1002\/cti2.1187","article-title":"Blockade of IL-33 signalling attenuates osteoarthritis","volume":"9","author":"He","year":"2020","journal-title":"Clin Transl Immunology"},{"key":"10.1016\/j.bbi.2026.106567_b0100","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41584-021-00724-w","article-title":"Mechanosignalling in cartilage: an emerging target for the treatment of osteoarthritis","volume":"18","author":"Hodgkinson","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbi.2026.106567_b0105","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s13041-021-00752-3","article-title":"The IL33 receptor ST2 contributes to mechanical hypersensitivity in mice with neuropathic pain","volume":"14","author":"Huang","year":"2021","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbi.2026.106567_b0110","doi-asserted-by":"crossref","first-page":"775","DOI":"10.1038\/nm.4324","article-title":"Local clearance of senescent cells attenuates the development of post-traumatic osteoarthritis and creates a pro-regenerative environment","volume":"23","author":"Jeon","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbi.2026.106567_b0115","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1078\/0344-0338-5710261","article-title":"Grading of chronic synovitis\u2013a histopathological grading system for molecular and diagnostic pathology","volume":"198","author":"Krenn","year":"2002","journal-title":"Pathol. Res. Pract."},{"key":"10.1016\/j.bbi.2026.106567_b0120","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00401-016-1653-y","article-title":"An updated histological classification system for multiple sclerosis lesions","volume":"133","author":"Kuhlmann","year":"2017","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbi.2026.106567_b0125","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.tig.2017.12.004","article-title":"Releasing Addiction Memories Trapped in Perineuronal Nets","volume":"34","author":"Lasek","year":"2018","journal-title":"Trends Genet."},{"key":"10.1016\/j.bbi.2026.106567_b0130","doi-asserted-by":"crossref","first-page":"2707","DOI":"10.1038\/s41467-024-46746-2","article-title":"The IL-33\/ST2 axis is protective against acute inflammation during the course of periodontitis","volume":"15","author":"Liu","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2026.106567_b0135","doi-asserted-by":"crossref","first-page":"1172","DOI":"10.1002\/art.42089","article-title":"Prevalence Trends of Site-specific Osteoarthritis from 1990 to 2019: Findings from the Global Burden of Disease Study 2019","volume":"74","author":"Long","year":"2022","journal-title":"Arthritis Rheumatol."},{"key":"10.1016\/j.bbi.2026.106567_b0140","first-page":"425","article-title":"miR-204 ameliorates osteoarthritis pain by inhibiting SP1-LRP1 signaling and blocking neuro-cartilage interaction","volume":"26","author":"Lu","year":"2023","journal-title":"Bioact. Mater."},{"key":"10.1016\/j.bbi.2026.106567_b0145","doi-asserted-by":"crossref","first-page":"2098","DOI":"10.1152\/jn.00748.2005","article-title":"Inflammatory mediators enhance the excitability of chronically compressed dorsal root ganglion neurons","volume":"95","author":"Ma","year":"2006","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbi.2026.106567_b0150","doi-asserted-by":"crossref","first-page":"14059","DOI":"10.1523\/JNEUROSCI.3699-07.2007","article-title":"Multiple sites for generation of ectopic spontaneous activity in neurons of the chronically compressed dorsal root ganglion","volume":"27","author":"Ma","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106567_b0155","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/s44158-025-00228-z","article-title":"A type-5 metabotropic glutamate receptor-perineuronal net axis shapes the function of cortical GABAergic interneurons in chronic pain","volume":"5","author":"Mascio","year":"2025","journal-title":"J Anesth Analg Crit Care"},{"key":"10.1016\/j.bbi.2026.106567_b0160","doi-asserted-by":"crossref","first-page":"1128","DOI":"10.1097\/j.pain.0000000000003563","article-title":"Formation of perineuronal nets within a thalamocortical circuit shapes mechanical and thermal pain thresholds in mice with neuropathic pain","volume":"166","author":"Mascio","year":"2025","journal-title":"Pain"},{"key":"10.1016\/j.bbi.2026.106567_b0165","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1523\/JNEUROSCI.1714-21.2022","article-title":"A Progressive Build-up of Perineuronal Nets in the Somatosensory Cortex is Associated with the Development of Chronic Pain in mice","volume":"42","author":"Mascio","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106567_b0170","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1038\/mt.2010.19","article-title":"Comparison of AAV serotypes for gene delivery to dorsal root ganglion neurons","volume":"18","author":"Mason","year":"2010","journal-title":"Mol. Ther."},{"key":"10.1016\/j.bbi.2026.106567_b0175","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.1001\/jama.2017.5283","article-title":"Effect of Intra-articular Triamcinolone vs Saline on knee Cartilage volume and Pain in patients with knee Osteoarthritis: a Randomized Clinical Trial","volume":"317","author":"McAlindon","year":"2017","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbi.2026.106567_b0180","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.nbd.2010.05.015","article-title":"Aggrecan expression, a component of the inhibitory interneuron perineuronal net, is altered following an early-life seizure","volume":"39","author":"McRae","year":"2010","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbi.2026.106567_b0185","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1016\/j.joca.2019.11.006","article-title":"The innate immune response as a mediator of osteoarthritis pain","volume":"28","author":"Miller","year":"2020","journal-title":"Osteoarthritis Cartilage"},{"key":"10.1016\/j.bbi.2026.106567_b0190","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1038\/s41584-025-01223-y","article-title":"The role of the immune system in osteoarthritis: mechanisms, challenges and future directions","volume":"21","author":"Moulin","year":"2025","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbi.2026.106567_b0195","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.907750","article-title":"Obesity, Inflammation, and Immune System in Osteoarthritis","volume":"13","author":"Nedunchezhiyan","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106567_b0200","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1007\/s11914-018-0477-1","article-title":"Mechanisms of Osteoarthritis (OA) Pain","volume":"16","author":"O'Neill","year":"2018","journal-title":"Curr. Osteoporos. Rep."},{"key":"10.1016\/j.bbi.2026.106567_b0205","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.bbi.2022.09.008","article-title":"Dorsal root ganglia CX3CR1 expressing monocytes\/macrophages contribute to arthritis pain","volume":"106","author":"Oggero","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106567_b0210","doi-asserted-by":"crossref","DOI":"10.1016\/j.berh.2023.101825","article-title":"Pain in osteoarthritis from a symptom to a disease","volume":"37","author":"Perrot","year":"2023","journal-title":"Best Pract. Res. Clin. Rheumatol."},{"key":"10.1016\/j.bbi.2026.106567_b0215","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.joca.2005.07.014","article-title":"Osteoarthritis cartilage histopathology: grading and staging","volume":"14","author":"Pritzker","year":"2006","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bbi.2026.106567_b0220","doi-asserted-by":"crossref","first-page":"C377","DOI":"10.1152\/ajpcell.00464.2022","article-title":"Cartilage extracellular matrix-derived matrikines in osteoarthritis","volume":"324","author":"Rapp","year":"2023","journal-title":"Am. J. Physiol. Cell Physiol."},{"key":"10.1016\/j.bbi.2026.106567_b0225","doi-asserted-by":"crossref","first-page":"552","DOI":"10.1038\/nrn2852","article-title":"The axon initial segment and the maintenance of neuronal polarity","volume":"11","author":"Rasband","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2026.106567_b0230","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1038\/s41584-022-00749-9","article-title":"Synovial inflammation in osteoarthritis progression","volume":"18","author":"Sanchez-Lopez","year":"2022","journal-title":"Nat. Rev. Rheumatol."},{"key":"10.1016\/j.bbi.2026.106567_b0235","doi-asserted-by":"crossref","first-page":"1045","DOI":"10.1016\/j.joca.2024.04.002","article-title":"Sex differences in osteoarthritis prevalence, pain perception, physical function and therapeutics","volume":"32","author":"Segal","year":"2024","journal-title":"Osteoarthr. Cartil."},{"key":"10.1016\/j.bbi.2026.106567_b0240","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2025.1533335","article-title":"IL-33\/ST2 axis in diverse diseases: regulatory mechanisms and therapeutic potential","volume":"16","author":"Sheng","year":"2025","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106567_b0245","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23158197","article-title":"Reorganization of the Brain Extracellular Matrix in Hippocampal Sclerosis","volume":"23","author":"Sita\u0161","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106567_b0250","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1016\/j.neubiorev.2020.07.015","article-title":"Incubation of depression: ECM assembly and parvalbumin interneurons after stress","volume":"118","author":"Spijker","year":"2020","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2026.106567_b0255","doi-asserted-by":"crossref","first-page":"962","DOI":"10.3389\/fimmu.2018.00962","article-title":"Interleukin-33 Receptor (ST2) Deficiency Improves the Outcome of Staphylococcus aureus-Induced Septic Arthritis","volume":"9","author":"Staurengo-Ferrari","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106567_b0260","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1186\/s12974-020-02066-y","article-title":"Suppression of TLR4-MyD88 signaling pathway attenuated chronic mechanical pain in a rat model of endometriosis","volume":"18","author":"Su","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106567_b0265","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.bbi.2022.02.015","article-title":"Sestrin2 overexpression attenuates osteoarthritis pain via induction of AMPK\/PGC-1\u03b1-mediated mitochondrial biogenesis and suppression of neuroinflammation","volume":"102","author":"Sun","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106567_b0270","doi-asserted-by":"crossref","first-page":"3194","DOI":"10.1111\/bph.16195","article-title":"Inhibition of Brd4 alleviates osteoarthritis pain via suppression of neuroinflammation and activation of Nrf2-mediated antioxidant signalling","volume":"180","author":"Sun","year":"2023","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106567_b0275","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1093\/brain\/awaa102","article-title":"Myelin oligodendrocyte glycoprotein antibody-associated disease: an immunopathological study","volume":"143","author":"Takai","year":"2020","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2026.106567_b0280","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1111\/cei.13007","article-title":"Nerve growth factor regulation and production by macrophages in osteoarthritic synovium","volume":"190","author":"Takano","year":"2017","journal-title":"Clin. Exp. Immunol."},{"key":"10.1016\/j.bbi.2026.106567_b0285","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.abl6773","article-title":"Microglia-mediated degradation of perineuronal nets promotes pain","volume":"377","author":"Tansley","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.bbi.2026.106567_b0290","doi-asserted-by":"crossref","unstructured":"van Helvoort, E.M., Welsing, P.M.J., Jansen, M.P., Gielis, W.P., Loef, M., Kloppenburg, M., Blanco, F., Haugen, I.K., Berenbaum, F., Bay-Jensen, A.C., Ladel, C., Lalande, A., Larkin, J., Loughlin, J., Mobasheri, A., Weinans, H., Lafeber, F., Eijkelkamp, N., Mastbergen, S., 2021. Neuropathic pain in the IMI-APPROACH knee osteoarthritis cohort: prevalence and phenotyping. RMD open 7.","DOI":"10.1136\/rmdopen-2021-002025"},{"key":"10.1016\/j.bbi.2026.106567_b0295","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1007\/s12035-022-02772-z","article-title":"Enzymatic Degradation of Cortical Perineuronal Nets Reverses GABAergic Interneuron Maturation","volume":"59","author":"Willis","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106567_b0300","doi-asserted-by":"crossref","first-page":"2159","DOI":"10.1016\/j.cell.2025.02.007","article-title":"Peripheral nervous system microglia-like cells regulate neuronal soma size throughout evolution","volume":"188","author":"Wu","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2026.106567_b0305","doi-asserted-by":"crossref","unstructured":"Yamamoto, Y., Kadoya, K., Terkawi, M.A., Endo, T., Konno, K., Watanabe, M., Ichihara, S., Hara, A., Kaneko, K., Iwasaki, N., Ishijima, M., 2022. Neutrophils delay repair process in Wallerian degeneration by releasing NETs outside the parenchyma. Life Sci Alliance 5.","DOI":"10.26508\/lsa.202201399"},{"key":"10.1016\/j.bbi.2026.106567_b0310","doi-asserted-by":"crossref","first-page":"12189","DOI":"10.7150\/thno.48028","article-title":"IL-33\/ST2 induces neutrophil-dependent reactive oxygen species production and mediates gout pain","volume":"10","author":"Yin","year":"2020","journal-title":"Theranostics"},{"key":"10.1016\/j.bbi.2026.106567_b0315","doi-asserted-by":"crossref","first-page":"3359","DOI":"10.1152\/jn.1999.82.6.3359","article-title":"Enhanced excitability of sensory neurons in rats with cutaneous hyperalgesia produced by chronic compression of the dorsal root ganglion","volume":"82","author":"Zhang","year":"1999","journal-title":"J. Neurophysiol."},{"key":"10.1016\/j.bbi.2026.106567_b0320","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1136\/svn-2023-002791","article-title":"White matter disease derived from vascular and demyelinating origins","volume":"9","author":"Zhang","year":"2024","journal-title":"Stroke Vasc Neurol"},{"key":"10.1016\/j.bbi.2026.106567_b0325","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.57656","article-title":"Aberrant subchondral osteoblastic metabolism modifies Na(V)1.8 for osteoarthritis","volume":"9","author":"Zhu","year":"2020","journal-title":"Elife"},{"key":"10.1016\/j.bbi.2026.106567_b0330","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.jot.2024.07.010","article-title":"Neural and immune roles in osteoarthritis pain: Mechanisms and intervention strategies","volume":"48","author":"Zou","year":"2024","journal-title":"Journal of Orthopaedic Translation"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126003156?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126003156?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:55:30Z","timestamp":1793606130000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126003156"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":66,"alternative-id":["S0889159126003156"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106567","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dorsal root ganglion macrophages mediate osteoarthritis pain via disruption of sensory neuron perineuronal nets","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106567","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106567"}}