{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:28:18Z","timestamp":1793608098212,"version":"4.5.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,18]],"date-time":"2026-04-18T00:00:00Z","timestamp":1776470400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbi.2026.106773","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:09:56Z","timestamp":1776726596000},"page":"106773","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Evidence of central neuroimmune alterations in fibromyalgia: a systematic review of case-control studies"],"prefix":"10.1016","volume":"136","author":[{"ORCID":"https:\/\/orcid.org\/0009-0001-9103-3937","authenticated-orcid":false,"given":"Mar\u00e7al","family":"Cast\u00e1n-Sogas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Fust\u00e9-Escolano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.106773_b0005","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbi.2018.09.018","article-title":"Brain glial activation in fibromyalgia - a multi-site positron emission tomography investigation","volume":"75","author":"Albrecht","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2026.106773_b0010","doi-asserted-by":"crossref","first-page":"272","DOI":"10.3390\/medicina60020272","article-title":"Unraveling the complex web of fibromyalgia: a narrative review","volume":"60","author":"Al Sharie","year":"2024","journal-title":"Medicina (Kaunas)"},{"key":"10.1016\/j.bbi.2026.106773_b0015","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2019.12.020","article-title":"Peripheral immune aberrations in fibromyalgia: a systematic review, meta-analysis and meta-regression","volume":"87","author":"Andr\u00e9s-Rodr\u00edguez","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106773_b0020","doi-asserted-by":"crossref","first-page":"515","DOI":"10.2147\/JPR.S128508","article-title":"Evidence of both systemic inflammation and neuroinflammation in fibromyalgia patients, as assessed by a multiplex protein panel applied to the cerebrospinal fluid and to plasma","volume":"10","author":"B\u00e4ckryd","year":"2017","journal-title":"J. Pain Res."},{"issue":"5","key":"10.1016\/j.bbi.2026.106773_b0025","doi-asserted-by":"crossref","DOI":"10.7326\/AITC202003030","article-title":"Fibromyalgia","volume":"172","author":"Bair","year":"2020","journal-title":"Ann. Intern. Med."},{"issue":"12","key":"10.1016\/j.bbi.2026.106773_b0030","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0296103","article-title":"Brain-derived neurotrophic factor in fibromyalgia: a systematic review and meta-analysis of its role as a potential biomarker","volume":"18","author":"Behnoush","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2026.106773_b0035","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1146\/annurev-clinpsy-080621-045153","article-title":"Psychoneuroimmunology: an introduction to immune-to-brain communication and its implications for clinical psychology","volume":"19","author":"Bower","year":"2023","journal-title":"Annu. Rev. Clin. Psychol."},{"issue":"7","key":"10.1016\/j.bbi.2026.106773_b0040","doi-asserted-by":"crossref","first-page":"502","DOI":"10.1038\/nrn3516","article-title":"Cognitive and emotional control of pain and its disruption in chronic pain","volume":"14","author":"Bushnell","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2026.106773_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.semarthrit.2022.152060","article-title":"The economic burden of fibromyalgia: a systematic literature review","volume":"56","author":"D'Onghia","year":"2022","journal-title":"Semin. Arthritis Rheum."},{"issue":"2","key":"10.1016\/j.bbi.2026.106773_b0045","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.bbi.2006.09.006","article-title":"Twenty years of research on cytokine-induced sickness behavior","volume":"21","author":"Dantzer","year":"2007","journal-title":"Brain Behav. Immun."},{"issue":"90","key":"10.1016\/j.bbi.2026.106773_b0050","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3002193","article-title":"CXCL5 mediates UVB irradiation-induced pain","volume":"3","author":"Dawes","year":"2011","journal-title":"Sci. Transl. Med."},{"issue":"7","key":"10.1016\/j.bbi.2026.106773_b0055","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0303573","article-title":"Fibromyalgia pathogenesis explained by a neuroendocrine multistable model","volume":"19","author":"Demori","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2026.106773_b0060","doi-asserted-by":"crossref","first-page":"223","DOI":"10.3389\/fimmu.2015.00223","article-title":"Stress induces endotoxemia and low-grade inflammation by increasing barrier permeability","volume":"6","author":"de Punder","year":"2015","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.bbi.2026.106773_b0070","doi-asserted-by":"crossref","first-page":"456","DOI":"10.3390\/jcm9020456","article-title":"GDNF, a neuron-derived factor upregulated in glial cells during disease","volume":"9","author":"Duarte Azevedo","year":"2020","journal-title":"J. Clin. Med."},{"issue":"2","key":"10.1016\/j.bbi.2026.106773_b0075","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bpsgos.2022.01.006","article-title":"Systemic inflammatory biomarkers in DSM-5-defined disorders and COVID-19: evidence from published meta-analyses","volume":"3","author":"Duong","year":"2023","journal-title":"Biol. Psych. Global Open Sci."},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0080","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1038\/npp.2016.141","article-title":"In sickness and in health: the co-regulation of inflammation and social behavior","volume":"42","author":"Eisenberger","year":"2017","journal-title":"Neuropsychopharmacol.: Off. Publ. Am. College Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2026.106773_b0085","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.bbi.2023.09.003","article-title":"Anti-satellite glia cell IgG antibodies in fibromyalgia patients are related to symptom severity and to metabolite concentrations in thalamus and rostral anterior cingulate cortex","volume":"114","author":"Fanton","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"13","key":"10.1016\/j.bbi.2026.106773_b0090","doi-asserted-by":"crossref","first-page":"10443","DOI":"10.3390\/ijms241310443","article-title":"Pain Biomarkers in fibromyalgia syndrome: current understanding and future directions","volume":"24","author":"Favretti","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bbi.2026.106773_b0095","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.bbi.2026.106773_b0100","first-page":"1564","article-title":"Increased concentrations of nerve growth factor in cerebrospinal fluid of patients with fibromyalgia","volume":"26","author":"Giovengo","year":"1999","journal-title":"J. Rheumatol."},{"issue":"5","key":"10.1016\/j.bbi.2026.106773_b0105","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1523\/JNEUROSCI.1650-20.2020","article-title":"The neuroimmunology of chronic pain: from rodents to humans","volume":"41","author":"Grace","year":"2021","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0110","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1038\/npp.2016.199","article-title":"Inflammation, glutamate, and glia: a trio of trouble in mood disorders","volume":"42","author":"Haroon","year":"2017","journal-title":"Neuropsychopharmacol.: Off. Publ. Am.College Neuropsychopharmacol."},{"key":"10.1016\/j.bbi.2026.106773_b0115","doi-asserted-by":"crossref","first-page":"1760","DOI":"10.3389\/fimmu.2019.01760","article-title":"Gal-3BP negatively regulates NF-\u03baB signaling by inhibiting the activation of TAK1","volume":"10","author":"Hong","year":"2019","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.bbi.2026.106773_b0120","doi-asserted-by":"crossref","first-page":"5905","DOI":"10.3390\/ijms25115905","article-title":"Substance P's impact on chronic pain and psychiatric conditions-a narrative review","volume":"25","author":"Humes","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"Pt B","key":"10.1016\/j.bbi.2026.106773_b0125","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.nbd.2016.01.021","article-title":"Biology of GDNF and its receptors - relevance for disorders of the central nervous system","volume":"97","author":"Ib\u00e1\u00f1ez","year":"2017","journal-title":"Neurobiol. Dis."},{"issue":"7928","key":"10.1016\/j.bbi.2026.106773_b0130","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41586-022-05161-7","article-title":"Brainstem ADCYAP1+ neurons control multiple aspects of sickness behaviour","volume":"609","author":"Ilanges","year":"2022","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0135","doi-asserted-by":"crossref","first-page":"22333","DOI":"10.1038\/s41598-021-01773-7","article-title":"The trajectory of putative astroglial dysfunction in first episode schizophrenia: a longitudinal 7-Tesla MRS study","volume":"11","author":"Jeon","year":"2021","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.bbi.2026.106773_b0140","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41583-019-0218-1","article-title":"Astrocytes in chronic pain and itch","volume":"20","author":"Ji","year":"2019","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2026.106773_b0145","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.bbi.2021.10.019","article-title":"Inflammatory reactivity to the influenza vaccine is associated with changes in automatic social behavior","volume":"99","author":"Jolink","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"7","key":"10.1016\/j.bbi.2026.106773_b0150","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1097\/j.pain.0000000000001815","article-title":"Magnetic resonance imaging of neuroinflammation in chronic pain: a role for astrogliosis?","volume":"161","author":"Jung","year":"2020","journal-title":"Pain"},{"issue":"13","key":"10.1016\/j.bbi.2026.106773_b0155","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000033305","article-title":"Central metabolites and peripheral parameters associated neuroinflammation in fibromyalgia patients: a preliminary study","volume":"102","author":"Jung","year":"2023","journal-title":"Medicine"},{"key":"10.1016\/j.bbi.2026.106773_bib363","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbi.2021.02.019","article-title":"Depression and interleukin-6 signaling: A Mendelian Randomization study","volume":"95","author":"Kelly","year":"2021","journal-title":"Brain, behavior, and immunity"},{"key":"10.1016\/j.bbi.2026.106773_b0160","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jprot.2018.04.014","article-title":"Systematic analysis of the cerebrospinal fluid proteome of fibromyalgia patients","volume":"190","author":"Khoonsari","year":"2019","journal-title":"J. Proteomics"},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0165","doi-asserted-by":"crossref","DOI":"10.1111\/jnc.16206","article-title":"Unraveling the role of oligodendrocytes and myelin in pain","volume":"169","author":"Kim","year":"2025","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0170","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.semarthrit.2020.10.006","article-title":"The prevalence of psychiatric and chronic pain comorbidities in fibromyalgia: an ACTTION systematic review","volume":"51","author":"Kleykamp","year":"2021","journal-title":"Semin. Arthritis Rheum."},{"issue":"3","key":"10.1016\/j.bbi.2026.106773_b0175","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1007\/s12264-020-00608-1","article-title":"CXCL10\/CXCR3 signaling in the DRG exacerbates neuropathic pain in mice","volume":"37","author":"Kong","year":"2021","journal-title":"Neurosci. Bull."},{"issue":"7","key":"10.1016\/j.bbi.2026.106773_b0180","doi-asserted-by":"crossref","first-page":"1382","DOI":"10.1097\/j.pain.0000000000000507","article-title":"Do we need a third mechanistic descriptor for chronic pain states?","volume":"157","author":"Kosek","year":"2016","journal-title":"Pain"},{"issue":"32","key":"10.1016\/j.bbi.2026.106773_b0185","doi-asserted-by":"crossref","first-page":"10809","DOI":"10.1523\/JNEUROSCI.1487-12.2012","article-title":"Reactive astrocytes overexpress TSPO and are detected by TSPO positron emission tomography imaging","volume":"32","author":"Lavisse","year":"2012","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbi.2026.106773_b0190","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/S0304-3940(00)00901-0","article-title":"Neuroimmune relations in patients with fibromyalgia: a positron emission tomography study","volume":"282","author":"Lekander","year":"2000","journal-title":"Neurosci. Lett."},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0195","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1097\/BOR.0000000000000464","article-title":"The complexities of fibromyalgia and its comorbidities","volume":"30","author":"Lichtenstein","year":"2018","journal-title":"Curr. Opin. Rheumatol."},{"key":"10.1016\/j.bbi.2026.106773_b0200","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.bbi.2022.02.012","article-title":"Small \u201cdoses\u201d of inflammation initiate social sickness behavior","volume":"102","author":"Lindsay","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.bbi.2026.106773_b0205","doi-asserted-by":"crossref","first-page":"942","DOI":"10.3899\/jrheum.211170","article-title":"Microstructural evidence of neuroinflammation for psychological symptoms and pain in patients with fibromyalgia","volume":"49","author":"Lo","year":"2022","journal-title":"J. Rheumatol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_bib361","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1097\/j.pain.0000000000000707","article-title":"Towards a neurophysiological signature for fibromyalgia","volume":"158","author":"L\u00f3pez-Sol\u00e0","year":"2017","journal-title":"Pain"},{"issue":"6","key":"10.1016\/j.bbi.2026.106773_b0210","doi-asserted-by":"crossref","first-page":"e759","DOI":"10.1097\/j.pain.0000000000002480","article-title":"Transcriptional and cellular signatures of cortical morphometric remodelling in chronic pain","volume":"163","author":"Martins","year":"2022","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0215","doi-asserted-by":"crossref","first-page":"3949","DOI":"10.1038\/s41598-024-53874-8","article-title":"Identification of unique genomic signatures in patients with fibromyalgia and chronic pain","volume":"14","author":"Mohapatra","year":"2024","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.bbi.2026.106773_b0220","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1097\/j.pain.0000000000002927","article-title":"Evidence of neuroinflammation in fibromyalgia syndrome: a [18 F]DPA-714 positron emission tomography study","volume":"164","author":"Mueller","year":"2023","journal-title":"Pain"},{"issue":"5","key":"10.1016\/j.bbi.2026.106773_b0225","doi-asserted-by":"crossref","first-page":"e383","DOI":"10.1016\/S2665-9913(21)00032-1","article-title":"Central sensitisation in chronic pain conditions: latest discoveries and their potential for precision medicine","volume":"3","author":"Nijs","year":"2021","journal-title":"Lancet. Rheumatol."},{"issue":"10","key":"10.1016\/j.bbi.2026.106773_b0230","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1002\/glia.24052","article-title":"Activated microglia do not increase 18\u2009kDa translocator protein (TSPO) expression in the multiple sclerosis brain","volume":"69","author":"Nutma","year":"2021","journal-title":"Glia"},{"issue":"6","key":"10.1016\/j.bbi.2026.106773_b0240","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.1093\/rheumatology\/keab146","article-title":"Is fibromyalgia associated with a unique cytokine profile? A systematic review and meta-analysis","volume":"60","author":"O'Mahony","year":"2021","journal-title":"Rheumatology (Oxford)"},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0235","doi-asserted-by":"crossref","first-page":"11882","DOI":"10.1038\/s41598-017-11506-4","article-title":"Fibromyalgia and microglial TNF-\u03b1: translational research using human blood induced microglia-like cells","volume":"7","author":"Ohgidani","year":"2017","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bbi.2026.106773_b0245","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1002\/emmm.201202382","article-title":"Resolution of inflammation: an integrated view","volume":"5","author":"Ortega-G\u00f3mez","year":"2013","journal-title":"EMBO Mol. Med."},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0250","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1186\/s13643-016-0384-4","article-title":"Rayyan-a web and mobile app for systematic reviews","volume":"5","author":"Ouzzani","year":"2016","journal-title":"Syst. Rev."},{"key":"10.1016\/j.bbi.2026.106773_b0255","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"372","author":"Page","year":"2021","journal-title":"BMJ (Clin. Res. Ed.)"},{"key":"10.1016\/j.bbi.2026.106773_b0260","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.bbi.2020.11.027","article-title":"HPA axis regulation and epigenetic programming of immune-related genes in chronically stressed and non-stressed mid-life women","volume":"92","author":"Palma-Gudiel","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2026.106773_b0265","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1016\/j.pharmthera.2006.04.010","article-title":"Inhibitory effect of somatostatin on inflammation and nociception","volume":"112","author":"Pint\u00e9r","year":"2006","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbi.2026.106773_b0270","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105235","article-title":"Neurophysiological and psychosocial mechanisms of fibromyalgia: a comprehensive review and call for an integrative model","volume":"151","author":"Pinto","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0275","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1038\/s41584-022-00873-6","article-title":"Emotion regulation and the salience network: a hypothetical integrative model of fibromyalgia","volume":"19","author":"Pinto","year":"2023","journal-title":"Nat. Rev. Rheumatol."},{"issue":"8","key":"10.1016\/j.bbi.2026.106773_b0280","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1007\/s11916-013-0356-5","article-title":"Worldwide epidemiology of fibromyalgia","volume":"17","author":"Queiroz","year":"2013","journal-title":"Curr. Pain Headache Rep."},{"issue":"40","key":"10.1016\/j.bbi.2026.106773_b0285","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.1231-24.2024","article-title":"Neuron-glial interactions: implications for plasticity, behavior, and cognition","volume":"44","author":"Rangel-Gomez","year":"2024","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106773_b0290","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.pnpbp.2014.01.013","article-title":"Inflamed moods: a review of the interactions between inflammation and mood disorders","volume":"53","author":"Rosenblat","year":"2014","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"11","key":"10.1016\/j.bbi.2026.106773_b0295","doi-asserted-by":"crossref","first-page":"1593","DOI":"10.1002\/art.1780371106","article-title":"Elevated cerebrospinal fluid levels of substance P in patients with the fibromyalgia syndrome","volume":"37","author":"Russell","year":"1994","journal-title":"Arthritis Rheum."},{"issue":"4","key":"10.1016\/j.bbi.2026.106773_b0300","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1111\/j.1468-2982.2005.01048.x","article-title":"Glial cell line-derived neurotrophic factor and somatostatin levels in cerebrospinal fluid of patients affected by chronic migraine and fibromyalgia","volume":"26","author":"Sarchielli","year":"2006","journal-title":"Cephalalgia: An Int. J. Headache"},{"issue":"9","key":"10.1016\/j.bbi.2026.106773_b0305","doi-asserted-by":"crossref","first-page":"737","DOI":"10.1016\/j.jpain.2007.05.002","article-title":"Increased levels of neurotrophins are not specific for chronic migraine: evidence from primary fibromyalgia syndrome","volume":"8","author":"Sarchielli","year":"2007","journal-title":"J. Pain"},{"issue":"11","key":"10.1016\/j.bbi.2026.106773_b0310","doi-asserted-by":"crossref","first-page":"645","DOI":"10.1038\/s41584-020-00506-w","article-title":"Fibromyalgia: an update on clinical characteristics, aetiopathogenesis and treatment","volume":"16","author":"Sarzi-Puttini","year":"2020","journal-title":"Nat. Rev. Rheumatol."},{"issue":"6","key":"10.1016\/j.bbi.2026.106773_b0315","first-page":"514","article-title":"Interoception and inflammation in psychiatric disorders","volume":"3","author":"Savitz","year":"2018","journal-title":"Biol. Psychiatry: Cognit. Neurosci. Neuroimaging"},{"issue":"2","key":"10.1016\/j.bbi.2026.106773_b0320","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0246152","article-title":"Abnormal neuroinflammation in fibromyalgia and CRPS using [11C]-(R)-PK11195 PET","volume":"16","author":"Seo","year":"2021","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2026.106773_b0325","article-title":"Fractalkine\/CX3CR1 pathway in neuropathic pain: an update","volume":"2","author":"Silva","year":"2021","journal-title":"Front. Pain Res. (Lausanne, Switzerland)"},{"key":"10.1016\/j.bbi.2026.106773_b0330","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1146\/annurev-immunol-032713-120257","article-title":"TGF-\u03b2 activation and function in immunity","volume":"32","author":"Travis","year":"2014","journal-title":"Annu. Rev. Immunol."},{"issue":"6","key":"10.1016\/j.bbi.2026.106773_bib362","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178516","article-title":"Resting state electrical brain activity and connectivity in fibromyalgia","volume":"12","author":"Vanneste","year":"2017","journal-title":"PLoS One"},{"issue":"10","key":"10.1016\/j.bbi.2026.106773_b0335","doi-asserted-by":"crossref","first-page":"5085","DOI":"10.3390\/ijms25105085","article-title":"Chronic stress-induced neuroinflammation: relevance of rodent models to human disease","volume":"25","author":"White","year":"2024","journal-title":"Int. J. Mol. Sci."},{"issue":"6312","key":"10.1016\/j.bbi.2026.106773_b0340","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1126\/science.aaf8934","article-title":"Deconstructing the sensation of pain: the influence of cognitive processes on pain perception","volume":"354","author":"Wiech","year":"2016","journal-title":"Science (New York, N.Y.)"},{"issue":"3 Suppl","key":"10.1016\/j.bbi.2026.106773_b0345","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/j.pain.2010.09.030","article-title":"Central sensitization: implications for the diagnosis and treatment of pain","volume":"152","author":"Woolf","year":"2011","journal-title":"Pain"},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0350","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1186\/s12967-023-04477-w","article-title":"Micro-inflammation related gene signatures are associated with clinical features and immune status of fibromyalgia","volume":"21","author":"Yao","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.bbi.2026.106773_b0355","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1038\/s41398-019-0570-y","article-title":"Inflammation-related biomarkers in major psychiatric disorders: a cross-disorder assessment of reproducibility and specificity in 43 meta-analyses","volume":"9","author":"Yuan","year":"2019","journal-title":"Transl. Psychiatry"},{"issue":"6","key":"10.1016\/j.bbi.2026.106773_b0360","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/j.semarthrit.2007.09.003","article-title":"Central sensitivity syndromes: a new paradigm and group nosology for fibromyalgia and overlapping conditions, and the related issue of disease versus illness","volume":"37","author":"Yunus","year":"2008","journal-title":"Semin. Arthritis Rheum."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005210?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005210?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:55:17Z","timestamp":1793606117000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126005210"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":75,"alternative-id":["S0889159126005210"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106773","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Evidence of central neuroimmune alterations in fibromyalgia: a systematic review of case-control studies","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106773","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106773"}}