{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:27:56Z","timestamp":1793608076870,"version":"4.5.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100010870","name":"Qingdao Municipal Science and Technology Bureau","doi-asserted-by":"publisher","award":["22-3-3-hygg-25-hy"],"award-info":[{"award-number":["22-3-3-hygg-25-hy"]}],"id":[{"id":"10.13039\/501100010870","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014103","name":"Key Technology Research and Development Program of Shandong Province","doi-asserted-by":"publisher","award":["2025CXPT137"],"award-info":[{"award-number":["2025CXPT137"]}],"id":[{"id":"10.13039\/100014103","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100012905","name":"Shandong Province Department of Science and Technology","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012905","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002855","name":"Ministry of Science and Technology of the People's Republic of China","doi-asserted-by":"publisher","award":["STI2030-MajorProjects2021ZD0202900"],"award-info":[{"award-number":["STI2030-MajorProjects2021ZD0202900"]}],"id":[{"id":"10.13039\/501100002855","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbi.2026.106775","type":"journal-article","created":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T23:41:21Z","timestamp":1776728481000},"page":"106775","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Identification of Fibrinogen C Domain-Containing protein 1 (FIBCD1) as a novel target for treatment of Post-Traumatic stress disorder (PTSD) and discovery of a novel FIBCD1 inhibitor"],"prefix":"10.1016","volume":"136","author":[{"given":"Shengyao","family":"Ma","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhe","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4694-8801","authenticated-orcid":false,"given":"Fang","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hanting","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.106775_b0005","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jare.2018.10.002","article-title":"A selective inhibitor of the Polo-box domain of Polo-like kinase 1 identified by virtual screening","volume":"16","author":"Abdelfatah","year":"2019","journal-title":"J. Adv. Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0010","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1038\/s41467-019-13809-8","article-title":"Ketamine disinhibits dendrites and enhances calcium signals in prefrontal dendritic spines","volume":"11","author":"Ali","year":"2020","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2026.106775_b0015","doi-asserted-by":"crossref","first-page":"31209","DOI":"10.1038\/srep31209","article-title":"Dysregulated immune system networks in war veterans with PTSD is an outcome of altered miRNA expression and DNA methylation","volume":"6","author":"Bam","year":"2016","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbi.2026.106775_b0020","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0282347","article-title":"The role of FIBCD1 in response to Aspergillus fumigatus in lung epithelial cells","volume":"18","author":"Bhattacharya","year":"2023","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0025","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1003080","article-title":"Innate sensing of chitin and chitosan","volume":"9","author":"Bueter","year":"2013","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbi.2026.106775_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.bmc.2024.117829","article-title":"Chiral pyrrolidines as multipotent agents in Alzheimer and neurodegenerative diseases","volume":"110","author":"Carrieri","year":"2024","journal-title":"Bioorg. Med. Chem."},{"key":"10.1016\/j.bbi.2026.106775_b0035","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1146\/annurev-pharmtox-010617-052645","article-title":"Development and Therapeutic potential of Small-Molecule Modulators of Circadian Systems","volume":"58","author":"Chen","year":"2018","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"6","key":"10.1016\/j.bbi.2026.106775_b0040","doi-asserted-by":"crossref","first-page":"4279","DOI":"10.4049\/jimmunol.181.6.4279","article-title":"TLR-2 and IL-17A in chitin-induced macrophage activation and acute inflammation","volume":"181","author":"Da Silva","year":"2008","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2026.106775_b0045","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1222826","article-title":"Mitochondrial dysfunction as a possible trigger of neuroinflammation at post-traumatic stress disorder (PTSD)","volume":"14","author":"Dmytriv","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbi.2026.106775_b0050","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2024.1411652","article-title":"Phosphodiesterase 7 inhibitor reduces stress-induced behavioral and cytoarchitectural changes in C57BL\/6J mice by activating the BDNF\/TrkB pathway","volume":"15","author":"Dong","year":"2024","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0055","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12974-020-01842-0","article-title":"Stress-induced NLRP3 inflammasome activation negatively regulates fear memory in mice","volume":"17","author":"Dong","year":"2020","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106775_b0060","doi-asserted-by":"crossref","unstructured":"Elieh Ali Komi, D., Sharma, L., & Dela Cruz, C. S. 2018. Chitin and Its Effects on Inflammatory and Immune Responses. Clin Rev Allergy Immunol. 54(2), 213-223. https:\/\/doi.org\/10.1007\/s12016-017-8600-0.","DOI":"10.1007\/s12016-017-8600-0"},{"key":"10.1016\/j.bbi.2026.106775_b0065","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuint.2020.104921","article-title":"Involvement of microglia in disturbed fear memory regulation: possible microglial contribution to the pathophysiology of posttraumatic stress disorder","volume":"142","author":"Enomoto","year":"2021","journal-title":"Neurochem. Int."},{"issue":"4","key":"10.1016\/j.bbi.2026.106775_b0070","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1001\/jamapsychiatry.2013.4374","article-title":"Assessment of plasma C-reactive protein as a biomarker of posttraumatic stress disorder risk","volume":"71","author":"Eraly","year":"2014","journal-title":"JAMA Psychiat."},{"issue":"9","key":"10.1016\/j.bbi.2026.106775_b0075","doi-asserted-by":"crossref","DOI":"10.15252\/emmm.202215829","article-title":"FIBCD1 is an endocytic GAG receptor associated with a novel neurodevelopmental disorder","volume":"14","author":"Fell","year":"2022","journal-title":"EMBO Mol. Med."},{"issue":"4","key":"10.1016\/j.bbi.2026.106775_b0080","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1208\/s12248-016-9888-z","article-title":"Multi-Functional Diarylurea Small Molecule Inhibitors of TRPV1 with Therapeutic potential for Neuroinflammation","volume":"18","author":"Feng","year":"2016","journal-title":"AAPS J."},{"issue":"3","key":"10.1016\/j.bbi.2026.106775_b0085","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1007\/s11481-023-10064-z","article-title":"Emphasizing the Crosstalk between Inflammatory and Neural Signaling in Post-traumatic stress Disorder (PTSD)","volume":"18","author":"Govindula","year":"2023","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"13","key":"10.1016\/j.bbi.2026.106775_b0090","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.3390\/cells11132034","article-title":"Involvement of Nuclear factor-\u03baB in Inflammation and Neuronal Plasticity Associated with Post-Traumatic stress Disorder","volume":"11","author":"Gupta","year":"2022","journal-title":"Cells"},{"issue":"2","key":"10.1016\/j.bbi.2026.106775_b0095","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1192\/bjp.bp.114.148551","article-title":"Pharmacotherapy for post-traumatic stress disorder: systematic review and meta-analysis","volume":"206","author":"Hoskins","year":"2015","journal-title":"Br. J. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106775_b0100","doi-asserted-by":"crossref","first-page":"1967","DOI":"10.3389\/fimmu.2018.01967","article-title":"FIBCD1 Binds Aspergillus fumigatus and Regulates Lung Epithelial Response to Cell Wall Components","volume":"9","author":"Jepsen","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbi.2026.106775_b0105","doi-asserted-by":"crossref","first-page":"474","DOI":"10.1093\/ajcp\/aqy013","article-title":"Overexpression of FIBCD1 is Predictive of Poor Prognosis in Gastric Cancer","volume":"149","author":"Jiang","year":"2018","journal-title":"Am. J. Clin. Pathol."},{"issue":"12","key":"10.1016\/j.bbi.2026.106775_b0110","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.3390\/pharmaceutics16121611","article-title":"Drug delivery across the Blood-Brain Barrier: a New Strategy for the Treatment of Neurological Diseases","volume":"16","author":"Jiao","year":"2024","journal-title":"Pharmaceutics"},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0115","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1038\/s41398-022-02094-7","article-title":"The role of the immune system in posttraumatic stress disorder","volume":"12","author":"Katrinli","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"9","key":"10.1016\/j.bbi.2026.106775_b0120","doi-asserted-by":"crossref","first-page":"1825","DOI":"10.1007\/s00213-023-06424-5","article-title":"Therapeutic potential of NOX inhibitors in neuropsychiatric disorders","volume":"240","author":"Kaur","year":"2023","journal-title":"Psychopharmacology"},{"issue":"2","key":"10.1016\/j.bbi.2026.106775_b0125","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3390\/antiox9020107","article-title":"Inflammation in Post-Traumatic stress Disorder (PTSD): a Review of potential Correlates of PTSD with a Neurological Perspective","volume":"9","author":"Kim","year":"2020","journal-title":"Antioxidants (basel)."},{"key":"10.1016\/j.bbi.2026.106775_b0130","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.bbr.2017.12.037","article-title":"Using c-Jun to identify fear extinction learning-specific patterns of neural activity that are affected by single prolonged stress","volume":"341","author":"Knox","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0135","doi-asserted-by":"crossref","DOI":"10.1080\/20008198.2022.2040818","article-title":"Sex hormones and cortisol during experimental trauma memory consolidation: prospective association with intrusive memories","volume":"13","author":"Krinke","year":"2022","journal-title":"Eur. J. Psychotraumatol."},{"issue":"12","key":"10.1016\/j.bbi.2026.106775_b0140","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/s41398-017-0050-1","article-title":"Gene expression associated with PTSD in World Trade Center responders: an RNA sequencing study","volume":"7","author":"Kuan","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"Pt B","key":"10.1016\/j.bbi.2026.106775_b0145","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.expneurol.2016.04.019","article-title":"Neuroimaging genetic approaches to Posttraumatic stress Disorder","volume":"284","author":"Lebois","year":"2016","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.bbi.2026.106775_b0150","first-page":"953","volume":"10","author":"Lee","year":"2022","journal-title":"Neuroinflammation in Post-Traumatic Stress Disorder. Biomedicines."},{"issue":"7","key":"10.1016\/j.bbi.2026.106775_b0155","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1016\/j.cub.2023.02.035","article-title":"Mouse spontaneous behavior reflects individual variation rather than estrous state","volume":"33","author":"Levy","year":"2023","journal-title":"Curr. Biol."},{"issue":"7","key":"10.1016\/j.bbi.2026.106775_b0160","doi-asserted-by":"crossref","first-page":"3963","DOI":"10.1007\/s12035-023-03320-z","article-title":"Post-traumatic stress Disorder: Focus on Neuroinflammation","volume":"60","author":"Li","year":"2023","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0165","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12974-020-02069-9","article-title":"Microglial deletion and inhibition alleviate behavior of post-traumatic stress disorder in mice","volume":"18","author":"Li","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106775_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2025.115116","article-title":"Inhibition of phosphodiesterase-4 by rolipram alleviates anxiety-like behavior in mice with PTSD by modulating neuroinflammation and synaptic plasticity via cAMP signaling","volume":"162","author":"Lin","year":"2025","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.bbi.2026.106775_b0175","doi-asserted-by":"crossref","first-page":"1455","DOI":"10.3892\/etm.2020.8889","article-title":"Carboxyamidotriazole exerts anti-inflammatory activity in lipopolysaccharide-induced RAW264.7 macrophages by inhibiting NF-\u03baB and MAPKs pathways","volume":"20","author":"Lu","year":"2020","journal-title":"Exp. Ther. Med."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0180","first-page":"42","article-title":"Oxytocin vs. placebo effects on intrusive memory consolidation using a trauma film paradigm: a randomized, controlled experimental study in healthy women. Transl","volume":"13","author":"Maslahati","year":"2023","journal-title":"Psychiatry"},{"key":"10.1016\/j.bbi.2026.106775_b0185","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1016\/j.bbi.2022.01.004","article-title":"Subfornical organ interleukin 1 receptor: a novel regulator of spontaneous and conditioned fear associated behaviors in mice","volume":"101","author":"McMurray","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bbi.2026.106775_b0190","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1007\/s40801-022-00298-3","article-title":"Polypharmacy in Australian Veterans with Post-traumatic stress Disorder upon Admission to a Mental Health Facility: a Retrospective Chart Review","volume":"9","author":"Mellor","year":"2022","journal-title":"Drugs Real World Outcomes."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0195","first-page":"32","article-title":"Posttraumatic stress disorder: from diagnosis to prevention","volume":"5","author":"Miao","year":"2018","journal-title":"Mil. Med. Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0200","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1038\/npp.2016.167","article-title":"Therapeutic Implications of Brain-Immune Interactions: Treatment in translation","volume":"42","author":"Miller","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"20","key":"10.1016\/j.bbi.2026.106775_b0205","doi-asserted-by":"crossref","first-page":"12504","DOI":"10.3390\/ijms232012504","article-title":"The Genetic Basis for the increased Prevalence of Metabolic Syndrome among Post-Traumatic stress Disorder patients","volume":"23","author":"Misganaw","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106775_b0210","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbi.2014.06.201","article-title":"Greater amygdala activity and dorsomedial prefrontal-amygdala coupling are associated with enhanced inflammatory responses to stress","volume":"43","author":"Muscatell","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"13","key":"10.1016\/j.bbi.2026.106775_b0215","doi-asserted-by":"crossref","first-page":"7185","DOI":"10.3390\/ijms23137185","article-title":"The Role of Microglia in the (Mal)adaptive Response to Traumatic Experience in an Animal Model of PTSD","volume":"23","author":"Nahum","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"12","key":"10.1016\/j.bbi.2026.106775_b0220","doi-asserted-by":"crossref","first-page":"861","DOI":"10.1016\/j.biopsych.2017.10.002","article-title":"Associations of Trauma and Posttraumatic stress Disorder with Inflammation and Endothelial Function: on timing, Specificity, and Mechanisms","volume":"82","author":"O'Donovan","year":"2017","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106775_b0225","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2025.111298","article-title":"Serum lipid and plasma fatty acid profiles in PTSD patients and healthy individuals: Associations with symptoms, cognitive function, and inflammatory markers","volume":"138","author":"Ogawa","year":"2025","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0230","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/j.janxdis.2012.08.004","article-title":"The physical health consequences of PTSD and PTSD symptoms: a meta-analytic review","volume":"27","author":"Pacella","year":"2013","journal-title":"J. Anxiety Disord."},{"issue":"11","key":"10.1016\/j.bbi.2026.106775_b0235","doi-asserted-by":"crossref","first-page":"1002","DOI":"10.1016\/S2215-0366(15)00309-0","article-title":"Inflammatory markers in post-traumatic stress disorder: a systematic review, meta-analysis, and meta-regression","volume":"2","author":"Passos","year":"2015","journal-title":"Lancet Psychiatry"},{"issue":"9","key":"10.1016\/j.bbi.2026.106775_b0240","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2022.104861","article-title":"Sex-specific transcriptomic and epitranscriptomic signatures of PTSD-like fear acquisition","volume":"25","author":"Reis","year":"2022","journal-title":"iScience"},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0245","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1007\/s00210-023-02578-3","article-title":"Cilostazol pretreatment prevents PTSD-related anxiety behavior through reduction of hippocampal neuroinflammation","volume":"397","author":"Sadeghi","year":"2024","journal-title":"Naunyn Schmiedebergs Arch. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106775_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2025.108825","article-title":"The (neuro)inflammatory system in anxiety disorders and PTSD: potential treatment targets","volume":"269","author":"Sah","year":"2025","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.bbi.2026.106775_b0255","doi-asserted-by":"crossref","first-page":"3800","DOI":"10.4049\/jimmunol.0901526","article-title":"Characterization of FIBCD1 as an acetyl group-binding receptor that binds chitin","volume":"183","author":"Schlosser","year":"2009","journal-title":"J. Immunol."},{"issue":"5","key":"10.1016\/j.bbi.2026.106775_b0260","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1038\/s41386-021-01247-4","article-title":"Intranasal oxytocin administration impacts the acquisition and consolidation of trauma-associated memories: a double-blind randomized placebo-controlled experimental study in healthy women","volume":"47","author":"Schultebraucks","year":"2022","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2026.106775_b0265","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2023.1280891","article-title":"Expression of FIBCD1 by intestinal epithelial cells alleviates inflammation-driven tumorigenesis in a mouse model of colorectal cancer","volume":"13","author":"Shahgoli","year":"2023","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbi.2026.106775_b0270","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2023.1112837","article-title":"Neuroinflammation is a susceptibility factor in developing a PTSD-like phenotype","volume":"17","author":"Shanazz","year":"2023","journal-title":"Front. Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0275","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.ccell.2020.04.017","article-title":"Targeting FTO Suppresses Cancer Stem Cell Maintenance and Immune Evasion","volume":"38","author":"Su","year":"2020","journal-title":"Cancer Cell"},{"issue":"10","key":"10.1016\/j.bbi.2026.106775_b0280","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1016\/j.biopsych.2019.11.005","article-title":"Posttraumatic stress Disorder and Inflammation: Untangling Issues of Bidirectionality","volume":"87","author":"Sumner","year":"2020","journal-title":"Biol. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2026.106775_b0285","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1002\/jcc.21334","article-title":"AutoDock Vina: improving the speed and accuracy of docking with a new scoring function, efficient optimization, and multithreading","volume":"31","author":"Trott","year":"2010","journal-title":"J. Comput. Chem."},{"key":"10.1016\/j.bbi.2026.106775_b0290","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.bbi.2015.07.026","article-title":"Divergent responses of inflammatory mediators within the amygdala and medial prefrontal cortex to acute psychological stress","volume":"51","author":"Vecchiarelli","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.bbi.2026.106775_b0295","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1038\/tp.2013.27","article-title":"Anxiety disorders and inflammation in a large adult cohort","volume":"3","author":"Vogelzangs","year":"2013","journal-title":"Transl. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2026.106775_b0300","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1369\/0022155417743694","article-title":"Immunohistochemical Localization of Fibrinogen C Domain Containing 1 on Epithelial and Mucosal Surfaces in Human Tissues","volume":"66","author":"von Huth","year":"2018","journal-title":"J. Histochem. Cytochem."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0305","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1038\/s41398-023-02331-7","article-title":"Acute stress responses of autonomous nervous system, HPA axis, and inflammatory system in posttraumatic stress disorder","volume":"13","author":"von Majewski","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbi.2026.106775_b0310","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1111\/jnc.15439","article-title":"Inhibiting Brd4 alleviated PTSD-like behaviors and fear memory through regulating immediate early genes expression and neuroinflammation in rats","volume":"158","author":"Wang","year":"2021","journal-title":"J. Neurochem."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0315","first-page":"795","article-title":"FIBCD1 overexpression predicts poor prognosis in patients with hepatocellular carcinoma","volume":"19","author":"Wang","year":"2020","journal-title":"Oncol. Lett."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbc.2023.105552","article-title":"Crystal structures of human immune protein FIBCD1 suggest an extended binding site compatible with recognition of pathogen-associated carbohydrate motifs","volume":"300","author":"Williams","year":"2024","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbi.2026.106775_b0325","doi-asserted-by":"crossref","first-page":"945","DOI":"10.1016\/j.bbi.2024.05.016","article-title":"Cannabidiol ameliorates PTSD-like symptoms by inhibiting neuroinflammation through its action on CB2 receptors in the brain of male mice","volume":"119","author":"Xie","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbi.2026.106775_b0330","doi-asserted-by":"crossref","first-page":"21629","DOI":"10.1038\/s41598-020-78410-2","article-title":"Beta-hydroxybutyrate, an endogenous NLRP3 inflammasome inhibitor, attenuates anxiety-related behavior in a rodent post-traumatic stress disorder model","volume":"10","author":"Yamanashi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2026.106775_b0335","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jad.2020.02.044","article-title":"Immune biomarkers alterations in post-traumatic stress disorder: a systematic review and meta-analysis","volume":"268","author":"Yang","year":"2020","journal-title":"J. Affect. Disord."},{"issue":"10","key":"10.1016\/j.bbi.2026.106775_b0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0187017","article-title":"Identification of two immortalized cell lines, ECV304 and bEnd3, for in vitro permeability studies of blood-brain barrier","volume":"12","author":"Yang","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2026.106775_b0345","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2019.107780","article-title":"Social instability is an effective chronic stress paradigm for both male and female mice","volume":"160","author":"Yohn","year":"2019","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2026.106775_b0350","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2024.108729","article-title":"Targeting selective autophagy in CNS disorders by small-molecule compounds","volume":"263","author":"Zheng","year":"2024","journal-title":"Pharmacol. Ther."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005234?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005234?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:44:47Z","timestamp":1793605487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126005234"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":70,"alternative-id":["S0889159126005234"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106775","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Identification of Fibrinogen C Domain-Containing protein 1 (FIBCD1) as a novel target for treatment of Post-Traumatic stress disorder (PTSD) and discovery of a novel FIBCD1 inhibitor","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106775","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106775"}}