{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T08:27:44Z","timestamp":1793608064819,"version":"4.5.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301722"],"award-info":[{"award-number":["82301722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["32471027"],"award-info":[{"award-number":["32471027"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbi.2026.106794","type":"journal-article","created":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T22:21:56Z","timestamp":1777674116000},"page":"106794","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Rescuing prefrontal cortical excitation-inhibition imbalance with early-life microglial ablation ameliorates ASD-like behaviors in male BTBR mice"],"prefix":"10.1016","volume":"136","author":[{"given":"Xinggao","family":"Zhang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Meifeng","family":"Gong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenyang","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Luo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zijun","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhirui","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghui","family":"Zhao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuanyuan","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lina","family":"Nie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaotang","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.106794_b0005","doi-asserted-by":"crossref","first-page":"546","DOI":"10.3390\/toxics11060546","article-title":"Exposure to methylmercury at juvenile stage worsens autism-like symptoms in adult BTBR T+tf\/J mice due to lack of nuclear factor erythroid 2-related factor 2 signaling upregulation in periphery and brain","volume":"11","author":"Algahtani","year":"2023","journal-title":"Toxics"},{"key":"10.1016\/j.bbi.2026.106794_b0010","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1186\/s12974-024-03067-x","article-title":"The immunomodulatory effect of oral NaHCO3 is mediated by the splenic nerve: multivariate impact revealed by artificial neural networks","volume":"21","author":"Alvarez","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106794_b0015","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2019.112028","article-title":"Differences in the expression of restricted repetitive behaviors in female and Male BTBR T\u00a0+\u00a0tf\/J mice","volume":"372","author":"Amodeo","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2026.106794_b0020","article-title":"Prenatal maternal immune activation triggers lasting cell-specific transcriptomic dysregulation in the amygdala of primate offspring","author":"Ander","year":"2025","journal-title":"Mol. Psychiatry 31, 2803\u20132814"},{"key":"10.1016\/j.bbi.2026.106794_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2024.110134","article-title":"Sex differences in the BTBR idiopathic mouse model of autism spectrum disorders: behavioural and redox-related hippocampal alterations","volume":"260","author":"Bove","year":"2024","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbi.2026.106794_b0030","doi-asserted-by":"crossref","first-page":"1221","DOI":"10.1002\/glia.70000","article-title":"Myelination trajectory and microglial dynamics following repeated sevoflurane exposure in developing brain","volume":"73","author":"Che","year":"2025","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2026.106794_b0035","doi-asserted-by":"crossref","DOI":"10.1016\/j.jare.2025.01.030","article-title":"Astragaloside IV ameliorates autism-like behaviors in BTBR mice by modulating Camk2n2-dependent OXPHOS and neurotransmission in the mPFC","author":"Chen","year":"2025","journal-title":"J. Adv. Res. 77, 763-777"},{"key":"10.1016\/j.bbi.2026.106794_b0040","article-title":"From circuits to lifespan: translating mouse and human timelines with neuroimaging-based tractography. J. Neurosci.: off","volume":"45","author":"Cottam","year":"2025","journal-title":"J Soc. Neurosci."},{"key":"10.1016\/j.bbi.2026.106794_b0045","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12955-021-01669-0","article-title":"Impact of antipsychotics in children and adolescents with autism spectrum disorder: a systematic review and meta-analysis","volume":"19","author":"D\u2019Al\u00f2, G.L., De Crescenzo, F., Amato, L., Cruciani, F., Davoli, M., Fulceri, F., Minozzi, S., Mitrova, Z., Morgano, G.P., Nardocci, F., Saulle, R., Sch\u00fcnemann, H.J., Scattoni, M.L., ISACAGuideline Working Group","year":"2021","journal-title":"Health Qual. Life Outcomes"},{"key":"10.1016\/j.bbi.2026.106794_b0050","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.neuron.2019.10.035","article-title":"CUL3 deficiency causes social deficits and anxiety-like behaviors by impairing excitation-inhibition balance through the promotion of cap-dependent translation","volume":"105","author":"Dong","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2026.106794_b0055","doi-asserted-by":"crossref","first-page":"380","DOI":"10.1016\/j.neuron.2014.02.040","article-title":"CSF1 receptor signaling is necessary for microglia viability, which unmasks a cell that rapidly repopulates the microglia-depleted adult brain","volume":"82","author":"Elmore","year":"2014","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2026.106794_b0060","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0324191","article-title":"An experimental study of the dual modulation of the colchicine-induced rat model of alzheimer\u2019s disease by superparamagnetic iron oxide nanoparticles (SPIONs) and the soluble product of dipylidium caninum adult worm","volume":"20","author":"Elsharkawy","year":"2025","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2026.106794_b0065","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/j.brainresbull.2021.04.002","article-title":"Formalin-induced inflammatory pain increases excitability in locus coeruleus neurons","volume":"172","author":"Farahani","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbi.2026.106794_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2024.107568","article-title":"Targeting S100A9 attenuates social dysfunction by modulating neuroinflammation and myelination in a mouse model of autism","volume":"211","author":"Gong","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbi.2026.106794_b0075","doi-asserted-by":"crossref","first-page":"686","DOI":"10.1002\/glia.24664","article-title":"Microglial depletion, a new tool in neuroinflammatory disorders: comparison of pharmacological inhibitors of the CSF\u20101R","volume":"73","author":"Guenoun","year":"2025","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2026.106794_b0080","doi-asserted-by":"crossref","first-page":"1730","DOI":"10.1016\/j.cell.2015.11.023","article-title":"Neuroinflammatory TNF\u03b1 impairs memory via astrocyte signaling","volume":"163","author":"Habbas","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2026.106794_b0085","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1038\/s41398-023-02317-5","article-title":"Excitatory\/inhibitory imbalance in autism: the role of glutamate and GABA gene-sets in symptoms and cortical brain structure","volume":"13","author":"Hollestein","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106794_b0090","doi-asserted-by":"crossref","first-page":"1808","DOI":"10.1038\/s41380-020-0671-2","article-title":"Inhibition of colony stimulating factor 1 receptor corrects maternal inflammation-induced microglial and synaptic dysfunction and behavioral abnormalities","volume":"26","author":"Ikezu","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106794_b0095","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1002\/glia.23284","article-title":"Alterations in CA1 hippocampal synapses in a mouse model of fragile X syndrome","volume":"66","author":"Jawaid","year":"2018","journal-title":"Glia"},{"key":"10.1016\/j.bbi.2026.106794_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2023.114384","article-title":"Icariin alleviates autistic-like behavior, hippocampal inflammation and vGlut1 expression in adult BTBR mice","volume":"445","author":"Jiang","year":"2023","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2026.106794_b0105","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1016\/j.cell.2025.02.022","article-title":"Meningeal lymphatics-microglia axis regulates synaptic physiology","volume":"188","author":"Kim","year":"2025","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2026.106794_b0110","doi-asserted-by":"crossref","first-page":"9072","DOI":"10.1038\/s41467-024-53254-w","article-title":"Developmental mouse brain common coordinate framework","volume":"15","author":"Kronman","year":"2024","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2026.106794_b0115","article-title":"Isolation of hypothalamic microglia from freshly perfused adult mouse brain by magnetic-activated cell sorting","volume":"211, e66769","author":"Kyriakidou","year":"2024","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbi.2026.106794_b0120","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.bbi.2017.01.019","article-title":"Developmental microglial priming in postmortem autism spectrum disorder temporal cortex","volume":"62","author":"Lee","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106794_b0125","doi-asserted-by":"crossref","first-page":"6380","DOI":"10.1038\/s41380-021-01139-5","article-title":"Loss of liver X receptor \u03b2 in astrocytes leads to anxiety-like behaviors via regulating synaptic transmission in the medial prefrontal cortex in mice","volume":"26","author":"Li","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106794_b0130","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.jpsychires.2020.07.013","article-title":"Microglia mediated neuroinflammation in autism spectrum disorder","volume":"130","author":"Liao","year":"2020","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbi.2026.106794_b0135","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.110594","article-title":"Minocycline improves autism-related behaviors by modulating microglia polarization in a mouse model of autism","volume":"122","author":"Luo","year":"2023","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbi.2026.106794_b0140","article-title":"Nanoformulated bumetanide ameliorates social deficiency in BTBR mice model of autism spectrum disorder","volume":"13","author":"Lv","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106794_b0145","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00281-024-01017-6","article-title":"The role of microglia in early neurodevelopment and the effects of maternal immune activation","volume":"46","author":"Mastenbroek","year":"2024","journal-title":"Semin. Immunopathol."},{"key":"10.1016\/j.bbi.2026.106794_b0150","doi-asserted-by":"crossref","DOI":"10.1126\/science.aad8670","article-title":"Microglia development follows a stepwise program to regulate brain homeostasis","volume":"353","author":"Matcovitch-Natan","year":"2016","journal-title":"Science"},{"key":"10.1016\/j.bbi.2026.106794_b0155","doi-asserted-by":"crossref","first-page":"4958","DOI":"10.1523\/JNEUROSCI.1644-21.2022","article-title":"Microglial Tmem59 deficiency impairs phagocytosis of synapse and leads to autism-like behaviors in mice","volume":"42","author":"Meng","year":"2022","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106794_b0160","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1186\/s12974-024-03259-5","article-title":"Transient CSF1R inhibition ameliorates behavioral deficits in Cntnap2 knockout and valproic acid-exposed mouse models of autism","volume":"21","author":"Meng","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106794_b0165","doi-asserted-by":"crossref","first-page":"368","DOI":"10.1016\/j.biopsych.2010.05.024","article-title":"Microglial activation and increased microglial density observed in the dorsolateral prefrontal cortex in autism","volume":"68","author":"Morgan","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106794_b0170","doi-asserted-by":"crossref","first-page":"3178","DOI":"10.1038\/s41380-020-0748-y","article-title":"Autism spectrum heterogeneity: fact or artifact?","volume":"25","author":"Mottron","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106794_b0175","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2020.107323","article-title":"Aggravation of autism-like behavior in BTBR T+tf\/J mice by environmental pollutant, di-(2-ethylhexyl) phthalate: role of nuclear factor erythroid 2-related factor 2 and oxidative enzymes in innate immune cells and cerebellum","volume":"91","author":"Nadeem","year":"2021","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbi.2026.106794_b0180","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bbr.2019.02.031","article-title":"Nrf2 activator, sulforaphane ameliorates autism-like symptoms through suppression of Th17 related signaling and rectification of oxidant-antioxidant imbalance in periphery and brain of BTBR T+tf\/J mice","volume":"364","author":"Nadeem","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbi.2026.106794_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2021.110249","article-title":"Exposure to the plasticizer, di-(2-ethylhexyl) phthalate during juvenile period exacerbates autism-like behavior in adult BTBR T + tf\/J mice due to DNA hypomethylation and enhanced inflammation in brain and systemic immune cells","volume":"109","author":"Nadeem","year":"2021","journal-title":"Prog. Neuropsychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106794_b0190","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jneuroim.2014.11.018","article-title":"Microglial numbers attain adult levels after undergoing a rapid decrease in cell number in the third postnatal week","volume":"278","author":"Nikodemova","year":"2015","journal-title":"J. Neuroimmunol."},{"key":"10.1016\/j.bbi.2026.106794_b0195","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1038\/s41380-022-01506-w","article-title":"Genetics of glutamate and its receptors in autism spectrum disorder","volume":"27","author":"Nisar","year":"2022","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106794_b0200","doi-asserted-by":"crossref","first-page":"1596","DOI":"10.1016\/j.cell.2013.11.030","article-title":"Microglia promote learning-dependent synapse formation through BDNF","volume":"155","author":"Parkhurst","year":"2013","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2026.106794_b0205","volume":"eNeuro 2","author":"Perez-Pouchoulen","year":"2015","journal-title":"Morphological and Phagocytic Profile of Microglia in the Developing Rat Cerebellum."},{"key":"10.1016\/j.bbi.2026.106794_b0210","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1016\/j.neuron.2020.09.010","article-title":"Rescuing over-activated microglia restores cognitive performance in juvenile animals of the dp(16) mouse model of down syndrome","volume":"108","author":"Pinto","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2026.106794_b0215","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.cell.2019.08.053","article-title":"Microglia biology: one century of evolving concepts","volume":"179","author":"Prinz","year":"2019","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2026.106794_b0220","doi-asserted-by":"crossref","first-page":"4399","DOI":"10.3390\/ijms22094399","article-title":"Effects of haloperidol, risperidone, and aripiprazole on the immunometabolic properties of BV-2 microglial cells","volume":"22","author":"Racki","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106794_b0225","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.bbi.2021.04.008","article-title":"Early postnatal allergic airway inflammation induces dystrophic microglia leading to excitatory postsynaptic surplus and autism-like behavior","volume":"95","author":"Saitoh","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106794_b0230","doi-asserted-by":"crossref","DOI":"10.1136\/bmj-2023-076733","article-title":"Autism intervention meta-analysis of early childhood studies (project AIM): updated systematic review and secondary analysis","volume":"383","author":"Sandbank","year":"2023","journal-title":"BMJ"},{"key":"10.1016\/j.bbi.2026.106794_b0235","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0003067","article-title":"Unusual repertoire of vocalizations in the BTBR T+tf\/J mouse model of autism","volume":"3","author":"Scattoni","year":"2008","journal-title":"PLoS One"},{"key":"10.1016\/j.bbi.2026.106794_b0240","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2026.106794_b0245","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.pneurobio.2013.04.001","article-title":"Brain development in rodents and humans: identifying benchmarks of maturation and vulnerability to injury across species","volume":"106\u2013107","author":"Semple","year":"2013","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106794_b0250","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.neuroimage.2007.08.028","article-title":"Automated segmentation of the actively-stained mouse brain using multi-spectral MR microscopy","volume":"39","author":"Sharief","year":"2008","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2026.106794_b0255","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1016\/j.neuroscience.2010.09.059","article-title":"Low stress reactivity and neuroendocrine factors in the BTBR T+tf\/J mouse model of autism","volume":"171","author":"Silverman","year":"2010","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbi.2026.106794_b0260","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/s12993-024-00251-0","article-title":"Assessing sociability using the three-chamber social interaction test and the reciprocal interaction test in a genetic mouse model of ASD","volume":"20","author":"Szab\u00f3","year":"2024","journal-title":"Behav. Brain Funct. : BBF"},{"key":"10.1016\/j.bbi.2026.106794_b0265","doi-asserted-by":"crossref","first-page":"2569","DOI":"10.1007\/s10803-012-1513-0","article-title":"Microglia in the cerebral cortex in autism","volume":"42","author":"Tetreault","year":"2012","journal-title":"J. Autism Dev. Disord."},{"key":"10.1016\/j.bbi.2026.106794_b0270","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neubiorev.2021.07.023","article-title":"Neuroinflammation in autism spectrum disorders: exercise as a \u201cpharmacological\u201d tool","volume":"129","author":"Toscano","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2026.106794_b0275","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.1016\/j.neuron.2022.03.013","article-title":"Microglial phagocytosis of newborn cells is induced by endocannabinoids and sculpts sex differences in juvenile rat social play","volume":"110","author":"VanRyzin","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2026.106794_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.xpro.2024.103395","article-title":"Protocol for the generation of single-nuclei RNA-seq libraries and quantification of heterogeneous cell types activated during social interaction","volume":"5","author":"Walker","year":"2024","journal-title":"STAR Protoc."},{"key":"10.1016\/j.bbi.2026.106794_b0285","doi-asserted-by":"crossref","first-page":"291","DOI":"10.3389\/fnbeh.2018.00290","article-title":"Metformin administration during early postnatal life rescues autistic-like behaviors in the BTBR T+ Itpr3tf\/J mouse model of autism","volume":"12","author":"Wang","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbi.2026.106794_b0290","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000307","article-title":"Neuroinflammation mediates noise-induced synaptic imbalance and tinnitus in rodent models","volume":"17","author":"Wang","year":"2019","journal-title":"PLoS Biol."},{"key":"10.1016\/j.bbi.2026.106794_b0295","doi-asserted-by":"crossref","DOI":"10.1126\/science.adr1015","article-title":"Microglia replacement halts the progression of microgliopathy in mice and humans","volume":"389","author":"Wu","year":"2025","journal-title":"Science"},{"key":"10.1016\/j.bbi.2026.106794_b0300","doi-asserted-by":"crossref","first-page":"3862","DOI":"10.1523\/JNEUROSCI.1520-19.2020","article-title":"Ependymal Vps35 promotes ependymal cell differentiation and survival, suppresses microglial activation, and prevents neonatal hydrocephalus","volume":"40","author":"Wu","year":"2020","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106794_b0305","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2023.1125428","article-title":"Microglia and astrocytes underlie neuroinflammation and synaptic susceptibility in autism spectrum disorder","volume":"17","author":"Xiong","year":"2023","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbi.2026.106794_b0310","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.conb.2021.01.007","article-title":"The social dilemma: prefrontal control of mammalian sociability","volume":"68","author":"Yizhar","year":"2021","journal-title":"Curr. Opin. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106794_b0315","doi-asserted-by":"crossref","first-page":"11516","DOI":"10.3390\/ijms222111516","article-title":"The role of maternal immune activation in the pathogenesis of autism: a review of the evidence, proposed mechanisms and implications for treatment","volume":"22","author":"Zawadzka","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106794_b0320","doi-asserted-by":"crossref","first-page":"3539","DOI":"10.1007\/s00213-020-05634-5","article-title":"Neonatal curcumin treatment restores hippocampal neurogenesis and improves autism-related behaviors in a mouse model of autism","volume":"237","author":"Zhong","year":"2020","journal-title":"Psychopharmacology"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005428?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005428?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,11,2]],"date-time":"2026-11-02T07:46:40Z","timestamp":1793605600000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126005428"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":64,"alternative-id":["S0889159126005428"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106794","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Rescuing prefrontal cortical excitation-inhibition imbalance with early-life microglial ablation ameliorates ASD-like behaviors in male BTBR mice","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106794","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106794"}}