{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T01:30:24Z","timestamp":1789695024589,"version":"4.0.1"},"reference-count":39,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/100007834","name":"Ningbo Municipal Natural Science Foundation","doi-asserted-by":"publisher","award":["2025J060"],"award-info":[{"award-number":["2025J060"]}],"id":[{"id":"10.13039\/100007834","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82301397"],"award-info":[{"award-number":["82301397"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071239"],"award-info":[{"award-number":["82071239"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbi.2026.106797","type":"journal-article","created":{"date-parts":[[2026,5,11]],"date-time":"2026-05-11T11:44:38Z","timestamp":1778499878000},"page":"106797","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Role of AQP4 mediated glymphatic system dysfunction in postoperative neuroinflammation and cognitive dysfunction"],"prefix":"10.1016","volume":"137","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9829-5472","authenticated-orcid":false,"given":"Han","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lan","family":"Mo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wei","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Binkang","family":"Huang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daofan","family":"Sun","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Meng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhexi","family":"Chi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingying","family":"Lv","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rongjun","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiuzhong","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hui","family":"Yuan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junping","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaowei","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.106797_b0005","unstructured":"Monk TG, Weldon Bc Fau - Garvan CW, Garvan Cw Fau - Dede DE, Dede De Fau - van der Aa MT, van der Aa Mt Fau - Heilman KM, Heilman Km Fau - Gravenstein JS, et al. Predictors of cognitive dysfunction after major noncardiac surgery. (1528-1175 (Electronic))."},{"key":"10.1016\/j.bbi.2026.106797_b0010","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/9829487","article-title":"The Impact of Age on Clinical Outcomes of Coronary Artery Bypass Grafting: Long-Term results of a Real-World Registry","volume":"2017","author":"Nicolini","year":"2017","journal-title":"Biomed Res. Int."},{"issue":"10","key":"10.1016\/j.bbi.2026.106797_b0015","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.36985","article-title":"Postsurgery Subjective Cognitive and Short-Term memory Impairment among Middle-Aged chinese patients","volume":"6","author":"Yang","year":"2023","journal-title":"JAMA Netw. Open"},{"key":"10.1016\/j.bbi.2026.106797_b0020","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1426718","article-title":"Surgery induces neurocognitive disorder via neuroinflammation and glymphatic dysfunction in middle-aged mice with brain lymphatic drainage impairment","volume":"18","author":"Zhu","year":"2024","journal-title":"Front. Neurosci."},{"issue":"6","key":"10.1016\/j.bbi.2026.106797_b0025","doi-asserted-by":"crossref","first-page":"986","DOI":"10.1002\/ana.22664","article-title":"Resolving postoperative neuroinflammation and cognitive decline","volume":"70","author":"Terrando","year":"2011","journal-title":"Ann. Neurol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106797_b0030","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10787-018-00559-0","article-title":"Postoperative cognitive dysfunction in the aged: the collision of neuroinflammaging with perioperative neuroinflammation","volume":"27","author":"Luo","year":"2019","journal-title":"Inflammopharmacology"},{"issue":"3","key":"10.1016\/j.bbi.2026.106797_b0035","doi-asserted-by":"crossref","first-page":"2633","DOI":"10.1097\/JS9.0000000000002156","article-title":"The association between diabetes mellitus and postoperative cognitive dysfunction: a systematic review and meta-analysis","volume":"111","author":"Liu","year":"2025","journal-title":"Int. J. Surg."},{"key":"10.1016\/j.bbi.2026.106797_b0040","doi-asserted-by":"crossref","DOI":"10.1177\/17562864221114356","article-title":"Identification of individuals at risk for postoperative cognitive dysfunction (POCD)","volume":"15","author":"Yang","year":"2022","journal-title":"Ther. Adv. Neurol. Disord."},{"key":"10.1016\/j.bbi.2026.106797_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneuroim.2024.578403","article-title":"Macrophage-derived exosomes exacerbate postoperative cognitive dysfunction in mice through inflammation","volume":"394","author":"Qin","year":"2024","journal-title":"J. Neuroimmunol."},{"issue":"147","key":"10.1016\/j.bbi.2026.106797_b0050","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3003748","article-title":"A Paravascular Pathway Facilitates CSF Flow through the Brain Parenchyma and the Clearance of Interstitial Solutes, Including Amyloid \u03b2","volume":"4","author":"Iliff","year":"2012","journal-title":"Sci. Transl. Med."},{"issue":"10","key":"10.1016\/j.bbi.2026.106797_b0055","doi-asserted-by":"crossref","first-page":"3092","DOI":"10.1161\/STROKEAHA.114.006617","article-title":"Impaired Glymphatic Perfusion after strokes Revealed by Contrast-Enhanced MRI","volume":"45","author":"Gaberel","year":"2014","journal-title":"Stroke"},{"key":"10.1016\/j.bbi.2026.106797_b0060","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.82232","article-title":"Loss of aquaporin-4 results in glymphatic system dysfunction via brain-wide interstitial fluid stagnation","volume":"12","author":"Gomolka","year":"2023","journal-title":"Elife"},{"issue":"8002","key":"10.1016\/j.bbi.2026.106797_b0065","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/s41586-024-07132-6","article-title":"Multisensory gamma stimulation promotes glymphatic clearance of amyloid","volume":"627","author":"Murdock","year":"2024","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbi.2026.106797_b0070","doi-asserted-by":"crossref","first-page":"1014","DOI":"10.4049\/jimmunol.1200857","article-title":"Molecular Mechanisms responsible for the Selective and Low-Grade Induction of Proinflammatory Mediators in Murine Macrophages by Lipopolysaccharide","volume":"189","author":"Maitra","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbi.2026.106797_b0075","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.bbi.2020.04.057","article-title":"Cocaine-induced structural and functional impairments of the glymphatic pathway in mice","volume":"88","author":"Chen","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106797_b0080","article-title":"Amyloid-\u03b2-driven glymphatic dysfunction in Alzheimer\u2019s disease model mice is driven by Ca2+-mediated increases in astrocytic cholesterol","author":"Zhang","year":"2026","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2026.106797_b0085","doi-asserted-by":"crossref","first-page":"112","DOI":"10.1016\/j.biochi.2018.08.004","article-title":"A chronic LPS-induced low-grade inflammation fails to reproduce in lean mice the impairment of preference for oily solution found in diet-induced obese mice","volume":"159","author":"Bernard","year":"2019","journal-title":"Biochimie"},{"issue":"8","key":"10.1016\/j.bbi.2026.106797_b0090","doi-asserted-by":"crossref","DOI":"10.3390\/nu12082402","article-title":"The potential Effects of Probiotics and \u03c9-3 Fatty Acids on Chronic Low-Grade Inflammation","volume":"12","author":"Hutchinson","year":"2020","journal-title":"Nutrients"},{"issue":"2","key":"10.1016\/j.bbi.2026.106797_b0095","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1007\/s12264-021-00772-y","article-title":"Digoxin Ameliorates Glymphatic Transport and Cognitive Impairment in a Mouse Model of Chronic Cerebral Hypoperfusion","volume":"38","author":"Cao","year":"2021","journal-title":"Neurosci. Bull."},{"issue":"1","key":"10.1016\/j.bbi.2026.106797_b0100","doi-asserted-by":"crossref","DOI":"10.1038\/s41398-023-02614-z","article-title":"Melatonin alleviates depression-like behaviors and cognitive dysfunction in mice by regulating the circadian rhythm of AQP4 polarization","volume":"13","author":"Yao","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/j.bbi.2026.106797_b0105","doi-asserted-by":"crossref","first-page":"577","DOI":"10.1038\/s41593-022-01063-z","article-title":"Meningeal lymphatic vessels mediate neurotropic viral drainage from the central nervous system","volume":"25","author":"Li","year":"2022","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2026.106797_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.114282","article-title":"AQP4 mitigates chronic neuropathic pain-induced cognitive impairment in mice","volume":"440","author":"Zhang","year":"2023","journal-title":"Behav. Brain Res."},{"issue":"14","key":"10.1016\/j.bbi.2026.106797_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22147611","article-title":"Knockout of NPFFR2 Prevents LPS-Induced Depressive-like responses in mice","volume":"22","author":"Yu","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106797_b0120","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbi.2020.11.008","article-title":"Ibrutinib alleviates LPS-induced neuroinflammation and synaptic defects in a mouse model of depression","volume":"92","author":"Li","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"10","key":"10.1016\/j.bbi.2026.106797_b0125","doi-asserted-by":"crossref","first-page":"12574","DOI":"10.1007\/s12035-025-05072-4","article-title":"Trifluoperazine improves postoperative cognition by influencing astrocyte endfoot morphology and aquaporin-4 polarity","volume":"62","author":"Chen","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106797_b0130","article-title":"Dexmedetomidine and the glymphatic system: a new perspective in managing postoperative cognitive dysfunction","volume":"16","author":"Zhang","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106797_b0135","article-title":"Phosphorylation of AQP4 by LRRK2 R1441G impairs glymphatic clearance of IFN\u03b3 and aggravates dopaminergic neurodegeneration","volume":"10","author":"Huang","year":"2024","journal-title":"npj Parkinson's Dis."},{"issue":"8","key":"10.1016\/j.bbi.2026.106797_b0140","doi-asserted-by":"crossref","first-page":"1450","DOI":"10.1177\/0271678X241237073","article-title":"Long-term isoflurane anesthesia induces cognitive deficits via AQP4 depolarization mediated blunted glymphatic inflammatory proteins clearance","volume":"44","author":"Dong","year":"2024","journal-title":"J. Cereb. Blood Flow Metab."},{"issue":"5","key":"10.1016\/j.bbi.2026.106797_b0145","doi-asserted-by":"crossref","first-page":"542","DOI":"10.1001\/jamaneurol.2017.4913","article-title":"Association of Changes in Plasma Neurofilament Light and Tau Levels with Anesthesia and Surgery: results from the CAPACITY and ARCADIAN Studies","volume":"75","author":"Evered","year":"2018","journal-title":"JAMA Neurol."},{"issue":"3","key":"10.1016\/j.bbi.2026.106797_b0150","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20211275","article-title":"Glymphatic system clears extracellular tau and protects from tau aggregation and neurodegeneration","volume":"219","author":"Ishida","year":"2022","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.bbi.2026.106797_b0155","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-022-00999-5","article-title":"Loss of perivascular aquaporin-4 localization impairs glymphatic exchange and promotes amyloid \u03b2 plaque formation in mice","volume":"14","author":"Simon","year":"2022","journal-title":"Alzheimers Res. Ther."},{"issue":"11","key":"10.1016\/j.bbi.2026.106797_b0160","doi-asserted-by":"crossref","DOI":"10.3390\/cells9112418","article-title":"Pro-Inflammatory Role of AQP4 in mice Subjected to Intrastriatal Injections of the Parkinsonogenic Toxin MPP+","volume":"9","author":"Prydz","year":"2020","journal-title":"Cells"},{"issue":"13","key":"10.1016\/j.bbi.2026.106797_b0165","doi-asserted-by":"crossref","DOI":"10.1002\/advs.202417449","article-title":"Hybrid Electro\u2010optical Stimulation Improves Ischemic Brain damage by Augmenting the Glymphatic System","volume":"12","author":"Kim","year":"2025","journal-title":"Adv. Sci."},{"issue":"9","key":"10.1016\/j.bbi.2026.106797_b0170","article-title":"Aquaporin 4 deficiency eliminates the beneficial effects of voluntary exercise in a mouse model of Alzheimer\u2019s disease","volume":"17","author":"Wu","year":"2022","journal-title":"Neural Regen. Res."},{"issue":"9","key":"10.1016\/j.bbi.2026.106797_b0175","doi-asserted-by":"crossref","first-page":"11443","DOI":"10.1007\/s12035-025-04992-5","article-title":"Melatonin Mitigates sleep Restriction-Induced Cognitive and Glymphatic Dysfunction Via Aquaporin-4 Polarization","volume":"62","author":"Sun","year":"2025","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106797_b0180","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2024.114770","article-title":"Voluntary wheel exercise improves glymphatic clearance and ameliorates colitis-associated cognitive impairment in aged mice by inhibiting TRPV4-induced astrocytic calcium activity","volume":"376","author":"Li","year":"2024","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbi.2026.106797_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111215","article-title":"MMP-9 inhibition alleviates postoperative cognitive dysfunction by improving glymphatic function via regulating AQP4 polarity","volume":"126","author":"Zhu","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"2","key":"10.1016\/j.bbi.2026.106797_b0190","article-title":"Maiken Nedergaard increased glymphatic influx is correlated with high EEG delta power and low heart rate in mice under anesthesia","volume":"5","author":"Lauren","year":"2019","journal-title":"Sci. Adv."},{"issue":"6512","key":"10.1016\/j.bbi.2026.106797_b0195","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1126\/science.abb8739","article-title":"Glymphatic failure as a final common pathway","volume":"370","author":"Nedergaard","year":"2020","journal-title":"Science"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005453?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005453?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:46:47Z","timestamp":1789472807000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126005453"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":39,"alternative-id":["S0889159126005453"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106797","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Role of AQP4 mediated glymphatic system dysfunction in postoperative neuroinflammation and cognitive dysfunction","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106797","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106797"}}