{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:05:22Z","timestamp":1789473922580,"version":"build-2803163510"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82371937"],"award-info":[{"award-number":["82371937"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82071883"],"award-info":[{"award-number":["82071883"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","award":["CSTB2025NSCQ-GPX0698"],"award-info":[{"award-number":["CSTB2025NSCQ-GPX0698"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100005230","name":"Chongqing Natural Science Foundation","doi-asserted-by":"publisher","award":["CSTB2024NSCQ-MSX0236"],"award-info":[{"award-number":["CSTB2024NSCQ-MSX0236"]}],"id":[{"id":"10.13039\/501100005230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012334","name":"Graduate Scientific Research and Innovation Foundation of Chongqing","doi-asserted-by":"publisher","award":["CYB240063"],"award-info":[{"award-number":["CYB240063"]}],"id":[{"id":"10.13039\/501100012334","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100032579","name":"Beijing Medical Award Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100032579","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbi.2026.106819","type":"journal-article","created":{"date-parts":[[2026,5,20]],"date-time":"2026-05-20T06:43:00Z","timestamp":1779259380000},"page":"106819","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Systemic inflammation and white matter free water jointly explain chemotherapy-related cognitive decline in breast cancer"],"prefix":"10.1016","volume":"137","author":[{"given":"Xiaoyu","family":"Zhou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yixin","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yong","family":"Tan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lin","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jiahui","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hua","family":"Lan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ting","family":"Yin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daihong","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0239-6988","authenticated-orcid":false,"given":"Jiuquan","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.106819_b0005","first-page":"229","article-title":"Global cancer statistics 2022: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries","volume":"74","author":"Bray","year":"2024","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbi.2026.106819_b0010","first-page":"10","article-title":"Cancer statistics, 2025","volume":"75","author":"Siegel","year":"2025","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbi.2026.106819_b0015","doi-asserted-by":"crossref","first-page":"1925","DOI":"10.1093\/annonc\/mdz410","article-title":"Cancer-related cognitive impairment: an update on state of the art, detection, and management strategies in cancer survivors","volume":"30","author":"Lange","year":"2019","journal-title":"Ann. Oncol."},{"key":"10.1016\/j.bbi.2026.106819_b0020","doi-asserted-by":"crossref","first-page":"e848","DOI":"10.1093\/oncolo\/oyae090","article-title":"Cognitive impairment following breast cancer treatments: an umbrella review","volume":"29","author":"Oliva","year":"2024","journal-title":"Oncologist"},{"key":"10.1016\/j.bbi.2026.106819_b0025","doi-asserted-by":"crossref","DOI":"10.1016\/j.apjon.2023.100334","article-title":"Chemotherapy-related cognitive impairment: what we need to know and what we can do","volume":"11","author":"Miyashita","year":"2024","journal-title":"Asia Pac. J. Oncol. Nurs."},{"key":"10.1016\/j.bbi.2026.106819_b0030","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1016\/j.ejon.2012.06.002","article-title":"Impact of perceived cognitive impairment in breast cancer survivors","volume":"17","author":"Von Ah","year":"2013","journal-title":"Eur. J. Oncol. Nurs."},{"key":"10.1016\/j.bbi.2026.106819_b0035","doi-asserted-by":"crossref","first-page":"2135","DOI":"10.1038\/s41598-022-05682-1","article-title":"Prevalence of cognitive impairment following chemotherapy treatment for breast cancer: a systematic review and meta-analysis","volume":"12","author":"Whittaker","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2026.106819_b0040","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/s41568-025-00863-2","article-title":"Mechanisms and treatment of cancer therapy-induced peripheral and central neurotoxicity","volume":"25","author":"Karschnia","year":"2025","journal-title":"Nat. Rev. Cancer"},{"key":"10.1016\/j.bbi.2026.106819_b0045","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2020.173078","article-title":"Doxorubicin chemotherapy-induced \u201cchemo-brain\u201d: meta-analysis","volume":"881","author":"Eide","year":"2020","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106819_b0050","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12987-020-00196-2","article-title":"Choroid plexus and the blood-cerebrospinal fluid barrier in disease","volume":"17","author":"Sol\u00e1r","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.bbi.2026.106819_b0055","doi-asserted-by":"crossref","DOI":"10.3389\/fphar.2022.750507","article-title":"Mechanisms of chemotherapy-induced neurotoxicity","volume":"13","author":"Was","year":"2022","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106819_b0060","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26083532","article-title":"Breaking the barrier: the role of proinflammatory cytokines in BBB dysfunction","volume":"26","author":"Gryka-Marton","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106819_b0065","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/j.bbi.2022.12.004","article-title":"Microglia are implicated in the development of paclitaxel chemotherapy-associated cognitive impairment in female mice","volume":"108","author":"Grant","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106819_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2024.117085","article-title":"Chemotherapy-induced cognitive impairment and glia: a new take on chemobrain?","volume":"492","author":"Barbosa-Azevedo","year":"2024","journal-title":"Toxicol. Appl. Pharmacol."},{"key":"10.1016\/j.bbi.2026.106819_b0075","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2022.798704","article-title":"Paclitaxel chemotherapy elicits widespread brain anisotropy changes in a comprehensive mouse model of breast cancer survivorship: evidence from in vivo diffusion weighted imaging","volume":"12","author":"Otto","year":"2022","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbi.2026.106819_b0080","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1186\/s13058-018-1062-3","article-title":"Inflammation markers and cognitive performance in breast cancer survivors 20 years after completion of chemotherapy: a cohort study","volume":"20","author":"van der Willik","year":"2018","journal-title":"Breast Cancer Res."},{"key":"10.1016\/j.bbi.2026.106819_b0085","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1186\/s12905-025-03674-7","article-title":"Expression of inflammatory states in response to psychological distress in breast cancer survivors and its relationship to subjective memory function complaints","volume":"25","author":"Gan","year":"2025","journal-title":"BMC Womens Health"},{"key":"10.1016\/j.bbi.2026.106819_b0090","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1007\/s11682-016-9665-8","article-title":"Recovery from chemotherapy-induced white matter changes in young breast cancer survivors?","volume":"12","author":"Billiet","year":"2018","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.bbi.2026.106819_b0095","doi-asserted-by":"crossref","first-page":"2429","DOI":"10.1016\/j.neurobiolaging.2015.04.015","article-title":"Brain network alterations and vulnerability to simulated neurodegeneration in breast cancer","volume":"36","author":"Kesler","year":"2015","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2026.106819_b0100","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.jgo.2019.09.016","article-title":"Effects of chemotherapy on aging white matter microstructure: a longitudinal diffusion tensor imaging study","volume":"11","author":"Chen","year":"2020","journal-title":"J. Geriatr. Oncol."},{"key":"10.1016\/j.bbi.2026.106819_b0105","doi-asserted-by":"crossref","DOI":"10.1002\/hbm.70101","article-title":"Genetic associations among inflammation, white matter architecture, and extracellular free water","volume":"46","author":"Rodrigue","year":"2025","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.bbi.2026.106819_b0110","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1186\/s13229-021-00456-4","article-title":"Neurite orientation dispersion and density imaging reveals white matter microstructural alterations in adults with autism","volume":"12","author":"Andica","year":"2021","journal-title":"Mol. Autism"},{"key":"10.1016\/j.bbi.2026.106819_b0115","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1001\/jamaneurol.2025.1601","article-title":"White matter abnormalities and cognition in aging and alzheimer disease","volume":"82","author":"Peter","year":"2025","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbi.2026.106819_b0120","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1016\/j.bbi.2025.04.005","article-title":"Association between peripheral inflammation and body mass index on white matter integrity and free water in bipolar II depression","volume":"128","author":"Cao","year":"2025","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106819_b0125","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/j.bbi.2023.10.009","article-title":"Infection burden and its association with neurite orientation dispersion and density imaging markers in the UK Biobank","volume":"115","author":"Beydoun","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106819_b0130","doi-asserted-by":"crossref","DOI":"10.1002\/hbm.70334","article-title":"Glymphatic, structural, and cognitive changes during breast cancer chemotherapy: a longitudinal MRI study","volume":"46","author":"Zhou","year":"2025","journal-title":"Hum. Brain Mapp."},{"key":"10.1016\/j.bbi.2026.106819_b0135","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1016\/j.jval.2013.06.017","article-title":"Psychometric properties and measurement equivalence of the English and chinese versions of the functional assessment of cancer therapy-cognitive in asian patients with breast cancer","volume":"16","author":"Cheung","year":"2013","journal-title":"Value Health"},{"key":"10.1016\/j.bbi.2026.106819_b0140","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1200\/JCO.22.00406","article-title":"Elevated C-reactive protein and subsequent patient-reported cognitive problems in older breast cancer survivors: the thinking and living with cancer study","volume":"41","author":"Carroll","year":"2023","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbi.2026.106819_b0145","doi-asserted-by":"crossref","DOI":"10.1200\/JCO.18.00140","article-title":"Cancer-related cognitive outcomes among older breast cancer survivors in the thinking and living with cancer study","volume":"36","author":"Mandelblatt","year":"2018","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbi.2026.106819_b0150","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/S0033-3182(71)71479-0","article-title":"A rating instrument for anxiety disorders","volume":"12","author":"Zung","year":"1971","journal-title":"Psychosomatics"},{"key":"10.1016\/j.bbi.2026.106819_b0155","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1080\/13803395.2010.493149","article-title":"Improving digit span assessment of short-term verbal memory","volume":"33","author":"Woods","year":"2011","journal-title":"J. Clin. Exp. Neuropsychol."},{"key":"10.1016\/j.bbi.2026.106819_b0160","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1080\/23279095.2021.1961774","article-title":"The classical backward digit span task detects changes in working memory but is unsuitable for classifying the severity of dementia","volume":"30","author":"Yoshimura","year":"2023","journal-title":"Appl. Neuropsychol. Adult"},{"key":"10.1016\/j.bbi.2026.106819_b0165","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1177\/1073191115602552","article-title":"The trail making test","volume":"24","author":"Llin\u00e0s-Regl\u00e0","year":"2017","journal-title":"Assessment"},{"key":"10.1016\/j.bbi.2026.106819_b0170","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.1111\/1460-6984.12855","article-title":"Executive functioning during verbal fluency tasks in bilinguals: a systematic review","volume":"58","author":"Giovannoli","year":"2023","journal-title":"Int. J. Lang. Commun. Disord."},{"key":"10.1016\/j.bbi.2026.106819_b0175","doi-asserted-by":"crossref","first-page":"8","DOI":"10.3389\/fninf.2014.00008","article-title":"Dipy, a library for the analysis of diffusion MRI data","volume":"8","author":"Garyfallidis","year":"2014","journal-title":"Front. Neuroinf."},{"issue":"Suppl 1","key":"10.1016\/j.bbi.2026.106819_b0180","doi-asserted-by":"crossref","first-page":"S208","DOI":"10.1016\/j.neuroimage.2004.07.051","article-title":"Advances in functional and structural MR image analysis and implementation as FSL","volume":"23","author":"Smith","year":"2004","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2026.106819_b0185","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/mrm.22055","article-title":"Free water elimination and mapping from diffusion MRI","volume":"62","author":"Pasternak","year":"2009","journal-title":"Magn. Reson. Med."},{"key":"10.1016\/j.bbi.2026.106819_b0190","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1016\/j.neuroimage.2006.02.024","article-title":"Tract-based spatial statistics: voxelwise analysis of multi-subject diffusion data","volume":"31","author":"Smith","year":"2006","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2026.106819_b0195","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.212780","article-title":"Peak width of skeletonized mean diffusivity: a neuroimaging marker for white matter injury","volume":"306","author":"Zanon Zotin","year":"2023","journal-title":"Radiology"},{"key":"10.1016\/j.bbi.2026.106819_b0200","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1016\/j.neuroimage.2010.09.025","article-title":"A reproducible evaluation of ANTs similarity metric performance in brain image registration","volume":"54","author":"Avants","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2026.106819_b0205","doi-asserted-by":"crossref","DOI":"10.1148\/radiol.250513","article-title":"Susceptibility MRI helps predict mild cognitive impairment onset and cognitive decline in cognitively unimpaired older adults","volume":"316","author":"Chen","year":"2025","journal-title":"Radiology"},{"key":"10.1016\/j.bbi.2026.106819_b0210","doi-asserted-by":"crossref","first-page":"270","DOI":"10.3389\/fnagi.2019.00270","article-title":"Free water in white matter differentiates MCI and AD from control subjects","volume":"11","author":"Dumont","year":"2019","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbi.2026.106819_b0215","article-title":"Free water derived by multi-shell diffusion MRI reflects tau\/neuroinflammatory pathology in Alzheimer's disease","volume":"8","author":"Nakaya","year":"2022","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.1016\/j.bbi.2026.106819_b0220","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24032909","article-title":"Endothelial dysfunction in neurodegenerative diseases","volume":"24","author":"Fang","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106819_b0225","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26062440","article-title":"Impact of peripheral inflammation on blood-brain barrier dysfunction and its role in neurodegenerative diseases","volume":"26","author":"Beltran-Velasco","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.106819_b0230","doi-asserted-by":"crossref","first-page":"2489","DOI":"10.1038\/s41423-021-00757-x","article-title":"The blood-brain barrier in systemic infection and inflammation","volume":"18","author":"Galea","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbi.2026.106819_b0235","doi-asserted-by":"crossref","first-page":"E45","DOI":"10.1503\/jpn.240039","article-title":"Association of systemic inflammatory markers with white matter hyperintensities and microstructural injury: an analysis of UK Biobank data","volume":"50","author":"Qiao","year":"2025","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.bbi.2026.106819_b0240","first-page":"1","article-title":"Free-water: a promising structural biomarker for cognitive decline in aging and mild cognitive impairment","volume":"2","author":"Sathe","year":"2024","journal-title":"Imaging Neurosci. (Camb)"},{"key":"10.1016\/j.bbi.2026.106819_b0245","doi-asserted-by":"crossref","first-page":"e2221","DOI":"10.1212\/WNL.0000000000007449","article-title":"Cerebral white matter free water: a sensitive biomarker of cognition and function","volume":"92","author":"Maillard","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.bbi.2026.106819_b0250","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117040","article-title":"The association of white matter free water with cognition in older adults","volume":"219","author":"Gullett","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2026.106819_b0255","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/s13195-017-0292-4","article-title":"Distinct white matter microstructural abnormalities and extracellular water increases relate to cognitive impairment in Alzheimer's disease with and without cerebrovascular disease","volume":"9","author":"Ji","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bbi.2026.106819_b0260","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1007\/s00429-019-02017-1","article-title":"Diffusion magnetic resonance imaging-derived free water detects neurodegenerative pattern induced by interferon-\u03b3","volume":"225","author":"Febo","year":"2020","journal-title":"Brain Struct. Funct."},{"key":"10.1016\/j.bbi.2026.106819_b0265","doi-asserted-by":"crossref","first-page":"1707","DOI":"10.1177\/0271678X221093579","article-title":"Free-water diffusion MRI detects structural alterations surrounding white matter hyperintensities in the early stage of cerebral small vessel disease","volume":"42","author":"Mayer","year":"2022","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbi.2026.106819_b0270","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1038\/s41380-019-0428-y","article-title":"Extracellular free water and glutathione in first-episode psychosis-a multimodal investigation of an inflammatory model for psychosis","volume":"26","author":"Lesh","year":"2021","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106819_b0275","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/mp.2017.43","article-title":"Greater extracellular free-water in first-episode psychosis predicts better neurocognitive functioning","volume":"23","author":"Lyall","year":"2018","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106819_b0280","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119029","article-title":"An atlas of white matter anatomy, its variability, and reproducibility based on constrained spherical deconvolution of diffusion MRI","volume":"254","author":"Radwan","year":"2022","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbi.2026.106819_b0285","doi-asserted-by":"crossref","first-page":"618","DOI":"10.1177\/02841851251321104","article-title":"A study on the changes of white matter microstructure in breast cancer patients undergoing chemotherapy based on DTI technology","volume":"66","author":"Li","year":"2025","journal-title":"Acta Radiol."},{"key":"10.1016\/j.bbi.2026.106819_b0290","article-title":"Longitudinal assessment of chemotherapy-induced brain connectivity changes in cerebral white matter and its correlation with cognitive functioning using the GQI","volume":"15","author":"Chen","year":"2024","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbi.2026.106819_b0295","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1007\/s11682-021-00551-3","article-title":"Focal white matter microstructural alteration after anthracycline-based systemic treatment in long-term breast cancer survivors: a structural magnetic resonance imaging study","volume":"16","author":"Zhang","year":"2022","journal-title":"Brain Imaging Behav."},{"key":"10.1016\/j.bbi.2026.106819_b0300","doi-asserted-by":"crossref","first-page":"3908","DOI":"10.1200\/JCO.21.00627","article-title":"Brain white matter microstructure as a risk factor for cognitive decline after chemotherapy for breast cancer","volume":"39","author":"de Ruiter","year":"2021","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbi.2026.106819_b0305","doi-asserted-by":"crossref","first-page":"1951","DOI":"10.1177\/0271678X231186959","article-title":"Cortical spreading depolarization-induced constriction of penetrating arteries can cause watershed ischemia: a potential mechanism for white matter lesions","volume":"43","author":"D\u00f6nmez-Demir","year":"2023","journal-title":"J. Cereb. Blood Flow Metab."},{"key":"10.1016\/j.bbi.2026.106819_b0310","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1016\/j.jaccao.2021.08.011","article-title":"Common pathophysiology in cancer, atrial fibrillation, atherosclerosis, and thrombosis: JACC: cardiooncology state-of-the-art review","volume":"3","author":"Leiva","year":"2021","journal-title":"JACC CardioOncol"},{"key":"10.1016\/j.bbi.2026.106819_b0315","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1007\/s12035-018-1224-4","article-title":"Chemotherapy-induced cognitive impairment is associated with cytokine dysregulation and disruptions in neuroplasticity","volume":"56","author":"Shi","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2026.106819_b0320","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/s11764-020-00863-1","article-title":"Functional connectome biotypes of chemotherapy-related cognitive impairment","volume":"14","author":"Kesler","year":"2020","journal-title":"J. Cancer Surviv."},{"key":"10.1016\/j.bbi.2026.106819_b0325","doi-asserted-by":"crossref","first-page":"5094","DOI":"10.1002\/hbm.24760","article-title":"Neurite orientation dispersion and density imaging (NODDI) and free-water imaging in Parkinsonism","volume":"40","author":"Mitchell","year":"2019","journal-title":"Hum. Brain Mapp."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005672?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126005672?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:39:39Z","timestamp":1789472379000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126005672"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":65,"alternative-id":["S0889159126005672"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106819","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Systemic inflammation and white matter free water jointly explain chemotherapy-related cognitive decline in breast cancer","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106819","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106819"}}