{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T12:07:23Z","timestamp":1789474043383,"version":"build-2803163510"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,23]],"date-time":"2026-06-23T00:00:00Z","timestamp":1782172800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006578","name":"Chi Mei healthcare system","doi-asserted-by":"publisher","award":["CMFHR112077"],"award-info":[{"award-number":["CMFHR112077"]}],"id":[{"id":"10.13039\/501100006578","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100020595","name":"National Science and Technology Council","doi-asserted-by":"publisher","award":["NSTC112-2314-B-384-005"],"award-info":[{"award-number":["NSTC112-2314-B-384-005"]}],"id":[{"id":"10.13039\/100020595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbi.2026.106878","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T22:23:15Z","timestamp":1781994195000},"page":"106878","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Pre-injury hypercholesterolemia is associated with microbiota-associated neurobehavioral vulnerability following traumatic brain injury"],"prefix":"10.1016","volume":"137","author":[{"given":"Guan-Yu","family":"Chen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiao-Yue","family":"Wee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min-Hsi","family":"Chiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuan-Chi","family":"Tu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Che-Chung","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yao-Tsung","family":"Yeh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinn-Rung","family":"Kuo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.106878_b0005","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1038\/sj.npp.1300677","article-title":"Antidepressant-like effect of D2\/3 receptor, but not D4 receptor, activation in the rat forced swim test","volume":"30","author":"Basso","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbi.2026.106878_b0010","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1001\/jama.2010.599","article-title":"Rates of major depressive disorder and clinical outcomes following traumatic brain injury","volume":"303","author":"Bombardier","year":"2010","journal-title":"J. Am. Med. Assoc."},{"key":"10.1016\/j.bbi.2026.106878_b0015","first-page":"639","article-title":"Next-generation beneficial microbes: the case of Akkermansia muciniphila","volume":"15","author":"Cani","year":"2017","journal-title":"Nat. Rev. Microbiol."},{"key":"10.1016\/j.bbi.2026.106878_b0020","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1007\/s12028-019-00891-5","article-title":"Effects of a high-fat diet on neuroinflammation and apoptosis in the acute stage after moderate traumatic brain injury in rats","volume":"33","author":"Chong","year":"2020","journal-title":"Neurocrit. Care"},{"key":"10.1016\/j.bbi.2026.106878_b0025","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/mp.2012.77","article-title":"The microbiome\u2013gut\u2013brain axis during early life regulates the hippocampal serotonergic system","volume":"18","author":"Clarke","year":"2013","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106878_b0030","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1038\/nrn3346","article-title":"Mind-altering microorganisms: the impact of the gut microbiota on brain and behaviour","volume":"13","author":"Cryan","year":"2012","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2026.106878_b0035","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The microbiota\u2013gut\u2013brain axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbi.2026.106878_b0040","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1038\/nature12820","article-title":"Diet rapidly and reproducibly alters the human gut microbiome","volume":"505","author":"David","year":"2014","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2026.106878_b0045","first-page":"1938","article-title":"The role of neuroinflammatory mediators in the pathogenesis of traumatic brain injury: a narrative review","volume":"13","author":"Do\u011fanyi\u011fit","year":"2022","journal-title":"ACS Chem. Nerosci."},{"key":"10.1016\/j.bbi.2026.106878_b0050","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1186\/s12974-024-03118-3","article-title":"Dysregulated brain\u2013gut axis in the setting of traumatic brain injury: review of mechanisms and anti-inflammatory pharmacotherapies","volume":"21","author":"El Baassiri","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106878_b0055","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1038\/nn.4476","article-title":"Interactions between the microbiota, immune and nervous systems in health and disease","volume":"20","author":"Fung","year":"2017","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbi.2026.106878_b0060","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1089\/089771504774129865","article-title":"Comparison of behavioral deficits and acute neuronal degeneration in rat lateral fluid percussion and weight-drop brain injury models","volume":"21","author":"Hallam","year":"2004","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbi.2026.106878_b0065","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/j.immuni.2017.08.009","article-title":"Foundations of immunometabolism and implications for metabolic health and disease","volume":"47","author":"Hotamisligil","year":"2017","journal-title":"Immunity"},{"key":"10.1016\/j.bbi.2026.106878_b0070","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1001\/archpsyc.61.1.42","article-title":"Major depression following traumatic brain injury","volume":"61","author":"Jorge","year":"2004","journal-title":"Arch. Gen. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106878_b0075","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1089\/neu.2012.2689","article-title":"Involvement of extracellular signal-regulated kinases in traumatic brain injury-induced depression in rodents","volume":"30","author":"Kuo","year":"2013","journal-title":"J. Neurotrauma"},{"key":"10.1016\/j.bbi.2026.106878_b0080","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1016\/j.tem.2022.04.003","article-title":"Metabolic disorders on cognitive dysfunction after traumatic brain injury","volume":"33","author":"Lai","year":"2022","journal-title":"Trends Endocrinol Metab"},{"key":"10.1016\/j.bbi.2026.106878_b0085","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S1474-4422(17)30371-X","article-title":"Traumatic brain injury: integrated approaches to improve prevention, clinical care, and research","volume":"16","author":"Maas","year":"2017","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbi.2026.106878_b0090","first-page":"412","article-title":"The gut microbiota\u2013brain axis in behaviour and brain disorders","volume":"17","author":"Morais","year":"2021","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbi.2026.106878_b0095","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1242\/dev.116.1.201","article-title":"NeuN, a neuronal specific nuclear protein in vertebrates","volume":"116","author":"Mullen","year":"1992","journal-title":"Development"},{"key":"10.1016\/j.bbi.2026.106878_b0100","doi-asserted-by":"crossref","first-page":"875","DOI":"10.3389\/fneur.2019.00875","article-title":"Gut microbiota as a therapeutic target to ameliorate the biochemical, neuroanatomical, and behavioral effects of traumatic brain injuries","volume":"10","author":"Rice","year":"2019","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbi.2026.106878_b0105","doi-asserted-by":"crossref","first-page":"915","DOI":"10.1016\/j.cell.2016.10.027","article-title":"The central nervous system and the gut microbiome","volume":"167","author":"Sharon","year":"2016","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2026.106878_b0110","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1038\/nature18846","article-title":"Diet\u2013microbiota interactions as moderators of human metabolism","volume":"535","author":"Sonnenburg","year":"2016","journal-title":"Nature"},{"key":"10.1016\/j.bbi.2026.106878_b0115","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.brainres.2018.03.015","article-title":"Neurotransmitter modulation by the gut microbiota","volume":"1693","author":"Strandwitz","year":"2018","journal-title":"Brain Res."},{"key":"10.1016\/j.bbi.2026.106878_b0120","first-page":"1590","article-title":"Traumatic brain injury in older adults: epidemiology, outcomes, and future implications","volume":"60","author":"Thompson","year":"2012","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbi.2026.106878_b0125","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.3389\/fimmu.2018.02757","article-title":"Traumatic brain injury in mice induces acute bacterial dysbiosis within the fecal microbiome","volume":"9","author":"Treangen","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106878_b0130","doi-asserted-by":"crossref","first-page":"4341","DOI":"10.1523\/JNEUROSCI.17-11-04341.1997","article-title":"Glial cell line-derived neurotrophic factor protects against ischemia-induced injury in the cerebral cortex","volume":"17","author":"Wang","year":"1997","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106878_b0140","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1093\/bja\/aem131","article-title":"Pathophysiology of traumatic brain injury","volume":"99","author":"Werner","year":"2007","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbi.2026.106878_b0145","first-page":"478","article-title":"Akkermansia muciniphila is a promising probiotic","volume":"10","author":"Zhang","year":"2019","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bbi.2026.106878_b0150","article-title":"Bidirectional crosstalk between microglia and serotonin signaling in neuroinflammation and CNS disorders","volume":"16","author":"Zheng","year":"2025","journal-title":"Front. Immunol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126006264?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126006264?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,15]],"date-time":"2026-09-15T11:47:55Z","timestamp":1789472875000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126006264"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":29,"alternative-id":["S0889159126006264"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106878","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Pre-injury hypercholesterolemia is associated with microbiota-associated neurobehavioral vulnerability following traumatic brain injury","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106878","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106878"}}