{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:35:46Z","timestamp":1793450146378,"version":"4.5.0"},"reference-count":42,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2026,11,1]],"date-time":"2026-11-01T00:00:00Z","timestamp":1793491200000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82471560"],"award-info":[{"award-number":["82471560"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2026,11]]},"DOI":"10.1016\/j.bbi.2026.106890","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:50:46Z","timestamp":1783353046000},"page":"106890","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Exosomes from bipolar disorder patients induce mania- and depression-like behaviors in mice via shared and distinct neuroimmune signatures"],"prefix":"10.1016","volume":"138","author":[{"given":"Tongtong","family":"Yao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liguo","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ya","family":"Su","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wanying","family":"Shao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fangcheng","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rui","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinghang","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibin","family":"Xi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7529-4408","authenticated-orcid":false,"given":"Yong","family":"Cheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Fu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bbi.2026.106890_b0005","doi-asserted-by":"crossref","first-page":"2674","DOI":"10.1038\/s41380-023-02073-4","article-title":"Mania-related effects on structural brain changes in bipolar disorder - a narrative review of the evidence","volume":"28","author":"Abe","year":"2023","journal-title":"Mol. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbi.2026.106890_b0010","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1001\/archgenpsychiatry.2010.22","article-title":"Mitochondrial complex I activity and oxidative damage to mitochondrial proteins in the prefrontal cortex of patients with bipolar disorder","volume":"67","author":"Andreazza","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"issue":"12","key":"10.1016\/j.bbi.2026.106890_b0015","doi-asserted-by":"crossref","DOI":"10.3390\/ijms21124407","article-title":"Transport of extracellular vesicles across the blood-brain barrier: brain pharmacokinetics and effects of inflammation","volume":"21","author":"Banks","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bbi.2026.106890_b0025","doi-asserted-by":"crossref","first-page":"1780","DOI":"10.1111\/jnc.16098","article-title":"The emerging neuroimmune hypothesis of bipolar disorder: an updated overview of neuroimmune and microglial findings","volume":"168","author":"Chaves-Filho","year":"2024","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2026.106890_b0030","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2023.106965","article-title":"Blood exosome sensing via neuronal insulin-like growth factor-1 regulates autism-related phenotypes","volume":"197","author":"Chen","year":"2023","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bbi.2026.106890_b0035","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/S2215-0366(21)00395-3","article-title":"Global, regional, and national burden of 12 mental disorders in 204 countries and territories, 1990-2019: a systematic analysis for the Global Burden of Disease Study 2019","volume":"9","author":"Collaborators","year":"2022","journal-title":"Lancet Psychiatry"},{"issue":"5","key":"10.1016\/j.bbi.2026.106890_b0040","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1111\/cns.12390","article-title":"Glial pathology in bipolar disorder: potential therapeutic implications","volume":"21","author":"Dong","year":"2015","journal-title":"CNS Neurosci. Ther."},{"issue":"6","key":"10.1016\/j.bbi.2026.106890_b0045","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1093\/schbul\/sby191","article-title":"Genome-wide, integrative analysis implicates exosome-derived microRNA dysregulation in schizophrenia","volume":"45","author":"Du","year":"2019","journal-title":"Schizophr. Bull."},{"issue":"3","key":"10.1016\/j.bbi.2026.106890_b0050","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1093\/schbul\/sbz114","article-title":"A network analysis of epigenetic and transcriptional regulation in a neurodevelopmental rat model of schizophrenia with implications for translational research","volume":"46","author":"Du","year":"2020","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbi.2026.106890_b0055","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/5717445","article-title":"Metabolomic identification of serum exosome-derived biomarkers for bipolar disorder","volume":"2022","author":"Du","year":"2022","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"1","key":"10.1016\/j.bbi.2026.106890_b0060","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/s41398-025-03370-y","article-title":"Music therapy as a preventive intervention for postpartum depression: modulation of synaptic plasticity, oxidative stress, and inflammation in a mouse model","volume":"15","author":"Fu","year":"2025","journal-title":"Transl. Psychiatry"},{"issue":"10027","key":"10.1016\/j.bbi.2026.106890_b0065","doi-asserted-by":"crossref","first-page":"1561","DOI":"10.1016\/S0140-6736(15)00241-X","article-title":"Bipolar disorder","volume":"387","author":"Grande","year":"2016","journal-title":"Lancet"},{"issue":"Pt 1","key":"10.1016\/j.bbi.2026.106890_b0070","article-title":"Neuroprotective effects of gypenosides on LPS-induced anxiety and depression-like behaviors","volume":"143","author":"Guo","year":"2024","journal-title":"Int. Immunopharmacol."},{"key":"10.1016\/j.bbi.2026.106890_b0020","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.bbi.2016.05.001","article-title":"Volume, metabolites and neuroinflammation of the hippocampus in bipolar disorder \u2013 A combined magnetic resonance imaging and positron emission tomography study","volume":"61","author":"Haarman","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.bbi.2026.106890_b0075","doi-asserted-by":"crossref","first-page":"932","DOI":"10.1038\/mp.2017.73","article-title":"Cortical abnormalities in bipolar disorder: an MRI analysis of 6503 individuals from the ENIGMA Bipolar Disorder Working Group","volume":"23","author":"Hibar","year":"2018","journal-title":"Mol. Psychiatry"},{"issue":"10","key":"10.1016\/j.bbi.2026.106890_b0080","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines9101428","article-title":"Exosomal let-7e, miR-21-5p, miR-145, miR-146a and miR-155 in predicting antidepressants response in patients with major depressive disorder","volume":"9","author":"Hung","year":"2021","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbi.2026.106890_b0085","doi-asserted-by":"crossref","first-page":"e256","DOI":"10.1017\/S0033291725000741","article-title":"Alterations of plasma neural-derived extracellular vesicles microRNAs in patients with bipolar disorder","volume":"55","author":"Jiang","year":"2025","journal-title":"Psychol. Med."},{"issue":"4","key":"10.1016\/j.bbi.2026.106890_b0090","doi-asserted-by":"crossref","first-page":"1094","DOI":"10.7150\/ijbs.79666","article-title":"Extracellular vesicles in mental disorders: a state-of-art review","volume":"19","author":"Kong","year":"2023","journal-title":"Int. J. Biol. Sci."},{"issue":"1","key":"10.1016\/j.bbi.2026.106890_b0095","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1038\/s41398-019-0492-8","volume":"9","author":"Lanz","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106890_b0100","doi-asserted-by":"crossref","first-page":"2689","DOI":"10.2147\/NDT.S277392","article-title":"Serum exosome-derived miR-139-5p as a potential biomarker for major depressive disorder","volume":"16","author":"Liang","year":"2020","journal-title":"Neuropsychiatr. Dis. Treat."},{"key":"10.1016\/j.bbi.2026.106890_b0105","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.euroneuro.2025.02.009","article-title":"Extracellular vesicles in mood disorders: a systematic review of human studies","volume":"94","author":"Llach","year":"2025","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106890_b0110","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/s40345-024-00327-w","article-title":"Correlations between multimodal neuroimaging and peripheral inflammation in different subtypes and mood states of bipolar disorder: a systematic review","volume":"12","author":"Long","year":"2024","journal-title":"Int. J. Bipolar Disord."},{"key":"10.1016\/j.bbi.2026.106890_b0115","first-page":"676","article-title":"Microglial CD206 Gene has potential as a State Marker of Bipolar Disorder","volume":"7","author":"Ohgidani","year":"2016","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbi.2026.106890_b0120","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1007\/s00406-022-01497-3","article-title":"Extracellular vesicle approach to major psychiatric disorders","volume":"273","author":"Oraki Kohshour","year":"2023","journal-title":"Eur. Arch. Psychiatry Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2026.106890_b0125","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41398-022-01944-8","article-title":"Differential expression of gene co-expression networks related to the mTOR signaling pathway in bipolar disorder","volume":"12","author":"Park","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"5","key":"10.1016\/j.bbi.2026.106890_b0130","doi-asserted-by":"crossref","first-page":"796","DOI":"10.4103\/1673-5374.268893","article-title":"Exosomes as mediators of neuron-glia communication in neuroinflammation","volume":"15","author":"Pascual","year":"2020","journal-title":"Neural Regen. Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.106890_b0135","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/s41398-024-02921-z","article-title":"Inflammatory mediators in major depression and bipolar disorder","volume":"14","author":"Poletti","year":"2024","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2026.106890_b0140","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.neuroscience.2015.05.018","article-title":"The role of inflammation and microglial activation in the pathophysiology of psychiatric disorders","volume":"300","author":"Reus","year":"2015","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.bbi.2026.106890_b0145","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1192\/bjp.2018.144","article-title":"Neurotrophins, cytokines, oxidative stress mediators and mood state in bipolar disorder: systematic review and meta-analyses","volume":"213","author":"Rowland","year":"2018","journal-title":"Br. J. Psychiatry"},{"issue":"9","key":"10.1016\/j.bbi.2026.106890_b0150","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1177\/2045125318769235","article-title":"Epidemiology and risk factors for bipolar disorder","volume":"8","author":"Rowland","year":"2018","journal-title":"Ther. Adv. Psychopharmacol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106890_b0155","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1038\/s41398-019-0459-9","article-title":"The emerging role of exosomes in mental disorders","volume":"9","author":"Saeedi","year":"2019","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbi.2026.106890_b0160","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S2215-0366(18)30048-8","article-title":"Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study","volume":"5","author":"Setiawan","year":"2018","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.bbi.2026.106890_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.670131","article-title":"CD206 expression in induced microglia-like cells from peripheral blood as a surrogate biomarker for the specific immune microenvironment of neurosurgical diseases including glioma","volume":"12","author":"Tanaka","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.106890_b0170","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jpsychires.2025.01.037","article-title":"Clinical studies of blood-borne extracellular vesicles in psychiatry: a systematic review","volume":"182","author":"Tunset","year":"2025","journal-title":"J. Psychiatr. Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.106890_b0175","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1152\/physrev.00042.2016","article-title":"Physiology of astroglia","volume":"98","author":"Verkhratsky","year":"2018","journal-title":"Physiol. Rev."},{"issue":"1","key":"10.1016\/j.bbi.2026.106890_b0180","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s12974-022-02492-0","article-title":"Microglia in depression: an overview of microglia in the pathogenesis and treatment of depression","volume":"19","author":"Wang","year":"2022","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbi.2026.106890_b0185","article-title":"The roles of extracellular vesicles in mental disorders: information carriers, biomarkers, therapeutic agents","volume":"16","author":"Wang","year":"2025","journal-title":"Front. Pharmacol."},{"issue":"6","key":"10.1016\/j.bbi.2026.106890_b0190","doi-asserted-by":"crossref","first-page":"1050","DOI":"10.1038\/s41386-020-0622-2","article-title":"Exosomes from patients with major depression cause depressive-like behaviors in mice with involvement of miR-139-5p-regulated neurogenesis","volume":"45","author":"Wei","year":"2020","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.bbi.2026.106890_b0195","article-title":"Exosomes in the diagnosis of neuropsychiatric diseases: a review","volume":"13","author":"Wu","year":"2024","journal-title":"Biology (Basel)"},{"issue":"3","key":"10.1016\/j.bbi.2026.106890_b0200","doi-asserted-by":"crossref","DOI":"10.5498\/wjp.v15.i3.102643","article-title":"Update on the roles and applications of extracellular vesicles in depression","volume":"15","author":"Wu","year":"2025","journal-title":"World J. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2026.106890_b0205","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s12951-022-01332-w","article-title":"Neuron secrete exosomes containing miR-9-5p to promote polarization of M1 microglia in depression","volume":"20","author":"Xian","year":"2022","journal-title":"J. Nanobiotechnol."},{"issue":"3","key":"10.1016\/j.bbi.2026.106890_b0210","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1111\/nan.12502","article-title":"Pro-inflammatory activation of microglia in the brain of patients with sepsis","volume":"45","author":"Zrzavy","year":"2019","journal-title":"Neuropathol. Appl. Neurobiol."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126006380?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126006380?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:29:41Z","timestamp":1793449781000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126006380"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,11]]},"references-count":42,"alternative-id":["S0889159126006380"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106890","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2026,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exosomes from bipolar disorder patients induce mania- and depression-like behaviors in mice via shared and distinct neuroimmune signatures","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106890","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"106890"}}