{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:54:36Z","timestamp":1790898876794,"version":"4.1.0"},"reference-count":77,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T00:00:00Z","timestamp":1787011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002996","name":"Netherlands Heart Foundation","doi-asserted-by":"publisher","award":["2019T056"],"award-info":[{"award-number":["2019T056"]}],"id":[{"id":"10.13039\/501100002996","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001826","name":"Netherlands Organisation for Health Research and Development","doi-asserted-by":"publisher","award":["10250022110004"],"award-info":[{"award-number":["10250022110004"]}],"id":[{"id":"10.13039\/501100001826","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100014470","name":"Netherlands Heart Institute","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100014470","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100010663","name":"H2020 European Research Council","doi-asserted-by":"publisher","award":["725229"],"award-info":[{"award-number":["725229"]}],"id":[{"id":"10.13039\/100010663","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000781","name":"European Research Council","doi-asserted-by":"publisher","award":["834513"],"award-info":[{"award-number":["834513"]}],"id":[{"id":"10.13039\/501100000781","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["1292.19.077"],"award-info":[{"award-number":["1292.19.077"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["2021\/TTW\/01038252"],"award-info":[{"award-number":["2021\/TTW\/01038252"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003246","name":"Dutch Research Council","doi-asserted-by":"publisher","award":["SPI 93-539"],"award-info":[{"award-number":["SPI 93-539"]}],"id":[{"id":"10.13039\/501100003246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100023794","name":"Genetic Heart Muscle Disease Foundation PLN","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100023794","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100023482","name":"Electronic Recycling Association","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100023482","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbi.2026.106962","type":"journal-article","created":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T15:13:12Z","timestamp":1787238792000},"page":"106962","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Doxorubicin administration modulates cancer-related fatigue in a time-of-day-dependent manner"],"prefix":"10.1016","volume":"139","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9099-5050","authenticated-orcid":false,"given":"Anneke","family":"Kastelein","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilse R.","family":"Kelters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amy Chin","family":"On","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Han","family":"Jiao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia Martinez","family":"Arenas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rico J.E.","family":"Derks","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elena","family":"S\u00e1nchez-L\u00f3pez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke M.","family":"Smits","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesco","family":"Angeli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Guglielmo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joost P.G.","family":"Sluijter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Giera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Xia","family":"Yi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacques","family":"Neefjes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vasco","family":"Sampaio-Pinto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Kervezee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda W.","family":"van Laake","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Johanna H.","family":"Meijer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"6","key":"10.1016\/j.bbi.2026.106962_b0005","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1093\/annonc\/mdw099","article-title":"Risk factors, prevalence, and course of severe fatigue after breast cancer treatment: a meta-analysis involving 12 327 breast cancer survivors","volume":"27","author":"Abrahams","year":"2016","journal-title":"Ann. Oncol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0010","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1186\/s40478-019-0838-8","article-title":"Attenuation of neuroinflammation reverses Adriamycin-induced cognitive impairments","volume":"7","author":"Allen","year":"2019","journal-title":"Acta Neuropathol. Commun."},{"issue":"4","key":"10.1016\/j.bbi.2026.106962_b0015","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0095192","article-title":"Homogenous 96-Plex PEA immunoassay exhibiting high sensitivity, specificity, and excellent scalability","volume":"9","author":"Assarsson","year":"2014","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0020","doi-asserted-by":"crossref","first-page":"16878","DOI":"10.1038\/s41598-017-17204-5","article-title":"QuPath: open source software for digital pathology image analysis","volume":"7","author":"Bankhead","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2026.106962_b0025","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v067.i01","article-title":"Fitting linear mixed-effects models using lme4","volume":"67","author":"Bates","year":"2015","journal-title":"J. Stat. Softw."},{"issue":"8","key":"10.1016\/j.bbi.2026.106962_b0030","doi-asserted-by":"crossref","first-page":"970","DOI":"10.1038\/s44161-024-00507-y","article-title":"Cytotoxic T cells drive doxorubicin-induced cardiac fibrosis and systolic dysfunction","volume":"3","author":"Bayer","year":"2024","journal-title":"Nat. Cardiovasc. Res."},{"issue":"8","key":"10.1016\/j.bbi.2026.106962_b0035","doi-asserted-by":"crossref","first-page":"1012","DOI":"10.6004\/jnccn.2015.0122","article-title":"Cancer-Related Fatigue, Version 2.2015","volume":"13","author":"Berger","year":"2015","journal-title":"J. Natl. Compr. Canc. Netw."},{"issue":"10","key":"10.1016\/j.bbi.2026.106962_b0040","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1111\/bph.15017","article-title":"Timing in drug absorption and disposition: the past, present, and future of chronopharmacokinetics","volume":"177","author":"Bicker","year":"2020","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0045","doi-asserted-by":"crossref","first-page":"41220","DOI":"10.1038\/srep41220","article-title":"Time-of-day dictates transcriptional inflammatory responses to cytotoxic chemotherapy","volume":"7","author":"Borniger","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2026.106962_b0050","doi-asserted-by":"crossref","unstructured":"Bouadi O, Yao C, Zeng J, et al. AutoMorFi: Automated Whole-image Morphometry in Fiji\/ImageJ for Diverse Image Analysis Needs. bioRxiv. Preprint posted online July 27, 2024:2024.07.26.605357. doi:10.1101\/2024.07.26.605357.","DOI":"10.1101\/2024.07.26.605357"},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0055","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/j.bbi.2010.09.010","article-title":"Fatigue and gene expression in human leukocytes: increased NF-\u03baB and decreased glucocorticoid signaling in breast cancer survivors with persistent fatigue","volume":"25","author":"Bower","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.106962_b0060","doi-asserted-by":"crossref","first-page":"S48","DOI":"10.1016\/j.bbi.2012.06.011","article-title":"Inflammation and cancer-related fatigue: Mechanisms, contributing factors, and treatment implications","volume":"30","author":"Bower","year":"2013","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0065","first-page":"H1036","article-title":"Disruption of the circadian clock within the cardiomyocyte influences myocardial contractile function, metabolism, and gene expression","volume":"294","author":"Bray","year":"2008","journal-title":"Am. J. Phys. Heart Circ. Phys."},{"issue":"4","key":"10.1016\/j.bbi.2026.106962_b0070","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1046\/j.1365-2826.2003.00989.x","article-title":"Role of melatonin in the regulation of human circadian rhythms and sleep","volume":"15","author":"Cajochen","year":"2003","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.bbi.2026.106962_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejon.2022.102096","article-title":"A pilot study of metabolomic pathways associated with fatigue in patients with colorectal cancer receiving chemotherapy","volume":"56","author":"Chou","year":"2022","journal-title":"Eur. J. Oncol. Nurs."},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0080","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2024.108884","article-title":"Spatially and temporally resolved metabolome of the human oral cavity","volume":"27","author":"Ciurli","year":"2024","journal-title":"iScience"},{"issue":"7","key":"10.1016\/j.bbi.2026.106962_b0085","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/s41569-019-0167-4","article-title":"Circadian rhythms and the molecular clock in cardiovascular biology and disease","volume":"16","author":"Crnko","year":"2019","journal-title":"Nat. Rev. Cardiol."},{"key":"10.1016\/j.bbi.2026.106962_b0090","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1016\/j.breast.2019.03.010","article-title":"Patient-reported health problems and healthcare use after treatment for early-stage breast cancer","volume":"46","author":"de Ligt;","year":"2019","journal-title":"Breast"},{"key":"10.1016\/j.bbi.2026.106962_b0095","unstructured":"De Luca A. Use of grip strength meter to assess the limb strength of mdx mice. Published online December 18, 2019. Accessed September 16, 2025. https:\/\/www.treat-nmd.org\/wp-content\/uploads\/2023\/07\/MDX-DMD_M.2.2.001.pdf."},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0100","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1097\/SPC.0000000000000205","article-title":"Impact of chemotherapy on cancer-related fatigue and cytokines in 1312 patients: a systematic review of quantitative studies","volume":"10","author":"Eyob","year":"2016","journal-title":"Curr. Opin. Support. Palliat. Care"},{"issue":"8","key":"10.1016\/j.bbi.2026.106962_b0105","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1038\/s41569-025-01126-1","article-title":"Anthracycline-induced cardiomyopathy: risk prediction, prevention and treatment","volume":"22","author":"Fabiani","year":"2025","journal-title":"Nat. Rev. Cardiol."},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0110","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1093\/toxsci\/kfx267","article-title":"Effects of cyclophosphamide and\/or doxorubicin in a murine model of postchemotherapy cognitive impairment","volume":"162","author":"Flanigan","year":"2018","journal-title":"Toxicol. Sci."},{"key":"10.1016\/j.bbi.2026.106962_b0115","doi-asserted-by":"crossref","DOI":"10.1016\/j.ebiom.2024.105141","article-title":"Association between endocrine adjuvant therapy intake timing and disease-free survival in patients with high-risk early breast cancer: results of a sub-study of the UCBG- UNIRAD trial","volume":"104","author":"Giacchetti","year":"2024","journal-title":"EBioMedicine"},{"issue":"15","key":"10.1016\/j.bbi.2026.106962_b0120","doi-asserted-by":"crossref","first-page":"3833","DOI":"10.1002\/cncr.26226","article-title":"Prolonged impact of chemotherapy on fatigue in breast cancer survivors: a longitudinal comparison with radiotherapy-treated breast cancer survivors and noncancer controls","volume":"118","author":"Goedendorp","year":"2012","journal-title":"Cancer"},{"issue":"3","key":"10.1016\/j.bbi.2026.106962_b0125","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1158\/0008-5472.CAN-17-2168","article-title":"Tumor-associated fatigue in cancer patients develops independently of IL1 signaling","volume":"78","author":"Grossberg","year":"2018","journal-title":"Cancer Res."},{"key":"10.1016\/j.bbi.2026.106962_b0130","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.bbi.2020.05.043","article-title":"Interleukin 6-independent metabolic reprogramming as a driver of cancer-related fatigue","volume":"88","author":"Grossberg","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0135","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1002\/pbc.23392","article-title":"Exercise training mitigates anthracycline-induced chronic cardiotoxicity in a juvenile rat model","volume":"59","author":"Hayward","year":"2012","journal-title":"Pediatr. Blood Cancer"},{"issue":"13","key":"10.1016\/j.bbi.2026.106962_b0140","doi-asserted-by":"crossref","first-page":"3407","DOI":"10.3390\/cancers15133407","article-title":"Relationships among inflammatory biomarkers and self-reported treatment-related symptoms in patients treated with chemotherapy for gynecologic cancer: a controlled comparison","volume":"15","author":"Hoogland","year":"2023","journal-title":"Cancers (Basel)"},{"key":"10.1016\/j.bbi.2026.106962_b0145","doi-asserted-by":"crossref","unstructured":"Jemal A, Ward EM, Johnson CJ, et al. Annual Report to the Nation on the Status of Cancer, 1975-2014, Featuring Survival. J Natl Cancer Inst. 2017;109(9):djx030. doi:10.1093\/jnci\/djx030.","DOI":"10.1093\/jnci\/djx030"},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0150","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.infbeh.2005.11.001","article-title":"Development of the 24-h rest-activity pattern in human infants","volume":"29","author":"Jenni","year":"2006","journal-title":"Infant Behav. Dev."},{"issue":"5","key":"10.1016\/j.bbi.2026.106962_b0155","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1038\/s41416-024-02704-9","article-title":"Why does circadian timing of administration matter for immune checkpoint inhibitors\u2019 efficacy?","volume":"131","author":"Karabou\u00e9","year":"2024","journal-title":"Br. J. Cancer"},{"key":"10.1016\/j.bbi.2026.106962_b0160","doi-asserted-by":"crossref","unstructured":"Kelters IR, Printezi MI, Ballesta A, et al. Chronotherapy as a novel strategy to limit anthracycline-induced cardiotoxicity. Cardiovascular Research. Published online October 2, 2025. doi:https:\/\/doi.org\/10.1093\/cvr\/cvaf179.","DOI":"10.1093\/cvr\/cvaf179"},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0165","doi-asserted-by":"crossref","first-page":"8909","DOI":"10.1038\/s41598-019-45322-9","article-title":"Role of proinflammatory cytokines in feedback modulation of circadian clock gene rhythms by saturated fatty acids","volume":"9","author":"Kim","year":"2019","journal-title":"Sci. Rep."},{"issue":"19","key":"10.1016\/j.bbi.2026.106962_b0170","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1016\/j.cell.2024.07.030","article-title":"Macrophage-mediated myelin recycling fuels brain cancer malignancy","volume":"187","author":"Kloosterman","year":"2024","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2026.106962_b0175","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest package: tests in linear mixed effects models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"J. Stat. Softw."},{"issue":"6","key":"10.1016\/j.bbi.2026.106962_b0180","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1016\/j.tics.2010.03.007","article-title":"Circadian clocks: genes, sleep, and cognition","volume":"14","author":"Kyriacou","year":"2010","journal-title":"Trends Cogn. Sci."},{"key":"10.1016\/j.bbi.2026.106962_b0185","doi-asserted-by":"crossref","unstructured":"Laas E, Hamy AS, Bachelot T, et al. Association Between Daily Timing of Everolimus and Survival in High-Risk HR+\/HER2- Early Breast Cancer: A Sub-Analysis of the UCBG-UNIRAD Trial. Clin Pharmacol Ther. Published online August 24, 2025. doi:10.1002\/cpt.70030.","DOI":"10.1002\/cpt.70030"},{"issue":"6","key":"10.1016\/j.bbi.2026.106962_b0190","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1161\/CIRCRESAHA.123.323520","article-title":"Circadian Rhythms in Cardiovascular Metabolism","volume":"134","author":"Lal","year":"2024","journal-title":"Circ. Res."},{"issue":"14","key":"10.1016\/j.bbi.2026.106962_b0195","doi-asserted-by":"crossref","first-page":"3013","DOI":"10.1016\/j.cell.2023.05.039","article-title":"Cooperative sensing of mitochondrial DNA by ZBP1 and cGAS promotes cardiotoxicity","volume":"186","author":"Lei","year":"2023","journal-title":"Cell"},{"key":"10.1016\/j.bbi.2026.106962_b0200","unstructured":"Lenth RV. emmeans: Estimated Marginal Means, aka Least-Squares Means. R package version 1.11.2-80001. Published online 2025. https:\/\/rvlenth.github.io\/emmeans\/."},{"key":"10.1016\/j.bbi.2026.106962_b0205","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev-pharmtox-051920-095416","article-title":"Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy","volume":"64","author":"L\u00e9vi","year":"2024","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0210","doi-asserted-by":"crossref","first-page":"16490","DOI":"10.1038\/s41598-019-52893-0","article-title":"Chemotherapy-induced neuroinflammation is associated with disrupted colonic and bacterial homeostasis in female mice","volume":"9","author":"Loman","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbi.2026.106962_b0215","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijnurstu.2020.103707","article-title":"Prevalence and risk factors of cancer-related fatigue: a systematic review and meta-analysis","volume":"111","author":"Ma","year":"2020","journal-title":"Int. J. Nurs. Stud."},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0220","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbi.2012.10.012","article-title":"Effects of 5-fluorouracil chemotherapy on fatigue: role of MCP-1","volume":"27","author":"Mahoney","year":"2013","journal-title":"Brain Behav. Immun."},{"issue":"37","key":"10.1016\/j.bbi.2026.106962_b0225","doi-asserted-by":"crossref","first-page":"E5472","DOI":"10.1073\/pnas.1607571113","article-title":"Metabolic features of chronic fatigue syndrome","volume":"113","author":"Naviaux","year":"2016","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"6315","key":"10.1016\/j.bbi.2026.106962_b0230","doi-asserted-by":"crossref","first-page":"1008","DOI":"10.1126\/science.aah4967","article-title":"Circadian physiology of metabolism","volume":"354","author":"Panda","year":"2016","journal-title":"Science"},{"issue":"W1","key":"10.1016\/j.bbi.2026.106962_b0235","doi-asserted-by":"crossref","first-page":"W398","DOI":"10.1093\/nar\/gkae253","article-title":"MetaboAnalyst 6.0: towards a unified platform for metabolomics data processing, analysis and interpretation","volume":"52","author":"Pang","year":"2024","journal-title":"Nucleic Acids Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0240","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1038\/ncomms2921","article-title":"Drug-induced histone eviction from open chromatin contributes to the chemotherapeutic effects of doxorubicin","volume":"4","author":"Pang","year":"2013","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0245","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1038\/s41580-019-0179-2","article-title":"Molecular mechanisms and physiological importance of circadian rhythms","volume":"21","author":"Patke","year":"2020","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"5","key":"10.1016\/j.bbi.2026.106962_b0250","doi-asserted-by":"crossref","DOI":"10.1093\/ehjopen\/oeaf100","article-title":"Morning administration of anthracyclines is associated with a lower risk of cancer therapy-related cardiac dysfunction","volume":"5","author":"Printezi","year":"2025","journal-title":"Eur Heart J Open"},{"issue":"26","key":"10.1016\/j.bbi.2026.106962_b0255","doi-asserted-by":"crossref","first-page":"15182","DOI":"10.1073\/pnas.1922072117","article-title":"Uncoupling DNA damage from chromatin damage to detoxify doxorubicin","volume":"117","author":"Qiao","year":"2020","journal-title":"Proc. Natl. Acad. Sci."},{"key":"10.1016\/j.bbi.2026.106962_b0260","unstructured":"R Core Team. R: A Language and Environment for Statistical Computing. Published online 2024. https:\/\/www.R-project.org\/."},{"key":"10.1016\/j.bbi.2026.106962_b0265","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.bbr.2016.07.043","article-title":"Long-lasting impairments in adult neurogenesis, spatial learning and memory from a standard chemotherapy regimen used to treat breast cancer","volume":"315","author":"Rendeiro","year":"2016","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0270","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1111\/ejn.14254","article-title":"Periodicity, repression, and the molecular architecture of the mammalian circadian clock","volume":"51","author":"Rosensweig","year":"2020","journal-title":"Eur. J. Neurosci."},{"key":"10.1016\/j.bbi.2026.106962_b0275","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.01195","article-title":"Neuroimmunology of behavioral comorbidities associated with cancer and cancer treatments","volume":"9","author":"Santos","year":"2018","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bbi.2026.106962_b0280","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1038\/nri3386","article-title":"Circadian control of the immune system","volume":"13","author":"Scheiermann","year":"2013","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2026.106962_b0285","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1101\/sqb.2015.80.027490","article-title":"Clock-talk: interactions between central and peripheral circadian oscillators in mammals","volume":"80","author":"Schibler","year":"2015","journal-title":"Cold Spring Harb. Symp. Quant. Biol."},{"key":"10.1016\/j.bbi.2026.106962_b0290","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2021.113607","article-title":"Neutralizing interleukin-6 in tumor-bearing mice does not abrogate behavioral fatigue induced by Lewis lung carcinoma","volume":"417","author":"Scott","year":"2022","journal-title":"Behav. Brain Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.106962_b0295","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/s40168-024-01758-4","article-title":"Distinct intestinal microbial signatures linked to accelerated systemic and intestinal biological aging","volume":"12","author":"Singh","year":"2024","journal-title":"Microbiome"},{"issue":"8","key":"10.1016\/j.bbi.2026.106962_b0300","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1023\/A:1008318932641","article-title":"Cancer-related fatigue: inevitable, unimportant and untreatable? Results of a multi-centre patient survey. Cancer Fatigue Forum","volume":"11","author":"Stone","year":"2000","journal-title":"Ann Oncol."},{"key":"10.1016\/j.bbi.2026.106962_b0305","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.bbi.2021.09.011","article-title":"Paclitaxel chemotherapy disrupts behavioral and molecular circadian clocks in mice","volume":"99","author":"Sullivan","year":"2022","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.bbi.2026.106962_b0310","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/j.tins.2024.12.011","article-title":"Mechanistic insights into chemotherapy-induced circadian disruption using rodent models","volume":"48","author":"Tapp","year":"2025","journal-title":"Trends Neurosci."},{"issue":"11","key":"10.1016\/j.bbi.2026.106962_b0315","doi-asserted-by":"crossref","first-page":"5954","DOI":"10.3390\/ijms23115954","article-title":"Neurotransmitters-key factors in neurological and neurodegenerative disorders of the central nervous system","volume":"23","author":"Teleanu","year":"2022","journal-title":"Int. J. Mol. Sci."},{"issue":"4673","key":"10.1016\/j.bbi.2026.106962_b0320","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1126\/science.6093249","article-title":"Adriamycin-induced DNA damage mediated by mammalian DNA topoisomerase II","volume":"226","author":"Tewey","year":"1984","journal-title":"Science"},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0325","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s11864-020-0707-5","article-title":"Cancer-related fatigue: causes and current treatment options","volume":"21","author":"Thong","year":"2020","journal-title":"Curr Treat Options Oncol."},{"issue":"15","key":"10.1016\/j.bbi.2026.106962_b0330","doi-asserted-by":"crossref","first-page":"3882","DOI":"10.3390\/cancers15153882","article-title":"Relationships among inflammatory biomarkers and objectively assessed physical activity and sleep during and after chemotherapy for gynecologic malignancies","volume":"15","author":"Tometich","year":"2023","journal-title":"Cancers (Basel)"},{"issue":"18","key":"10.1016\/j.bbi.2026.106962_b0335","doi-asserted-by":"crossref","first-page":"4262","DOI":"10.1111\/bph.70085","article-title":"Dexrazoxane protects against doxorubicin-induced cardiotoxicity in susceptible human living myocardial slices: a proof-of-concept study","volume":"182","author":"van der Geest","year":"2025","journal-title":"Br. J. Pharmacol."},{"issue":"8","key":"10.1016\/j.bbi.2026.106962_b0340","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0237096","article-title":"RandoMice, a novel, user-friendly randomization tool in animal research","volume":"15","author":"van Eenige","year":"2020","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0345","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1002\/ijc.34252","article-title":"Longitudinal associations of plasma metabolites with persistent fatigue among colorectal cancer survivors up to 2\u2009years after treatment","volume":"152","author":"van Roekel","year":"2023","journal-title":"Int. J. Cancer"},{"issue":"5","key":"10.1016\/j.bbi.2026.106962_b0350","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1161\/CIRCRESAHA.123.323346","article-title":"Exercise Inhibits Doxorubicin-Induced Cardiotoxicity via Regulating B Cells","volume":"134","author":"Wang","year":"2024","journal-title":"Circ. Res."},{"issue":"72","key":"10.1016\/j.bbi.2026.106962_b0355","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.abm2465","article-title":"The circadian immune system","volume":"7","author":"Wang","year":"2022","journal-title":"Sci. Immunol."},{"issue":"10","key":"10.1016\/j.bbi.2026.106962_b0360","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.3390\/cancers14102421","article-title":"Induction of fatigue by specific anthracycline cancer drugs through disruption of the circadian pacemaker","volume":"14","author":"Wang","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.bbi.2026.106962_b0365","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.bbi.2023.11.020","article-title":"Internal circadian misallignment in a mouse model of chemotherapy induced fatigue","volume":"115","author":"Wang","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0370","first-page":"123","article-title":"Clinical characteristics, pathophysiology, and management of noncentral nervous system cancer-related cognitive impairment in adults","volume":"65","author":"Wefel","year":"2015","journal-title":"CA Cancer J. Clin."},{"key":"10.1016\/j.bbi.2026.106962_b0375","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbi.2013.11.003","article-title":"A role for orexin in cytotoxic chemotherapy-induced fatigue","volume":"37","author":"Weymann","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbi.2026.106962_b0380","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1177\/1099800406290932","article-title":"The cancer chemotherapy drug etoposide (VP-16) induces proinflammatory cytokine production and sickness behavior-like symptoms in a mouse model of cancer chemotherapy-related symptoms","volume":"8","author":"Wood","year":"2006","journal-title":"Biol. Res. Nurs."},{"issue":"6","key":"10.1016\/j.bbi.2026.106962_b0385","first-page":"491","article-title":"A clinically translatable mouse model for chemotherapy-related fatigue","volume":"63","author":"Zombeck","year":"2013","journal-title":"Comp. Med."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126007105?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126007105?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:11:59Z","timestamp":1790896319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126007105"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":77,"alternative-id":["S0889159126007105"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106962","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Doxorubicin administration modulates cancer-related fatigue in a time-of-day-dependent manner","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.106962","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"106962"}}