{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:54:30Z","timestamp":1790898870644,"version":"4.1.0"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,9,10]],"date-time":"2026-09-10T00:00:00Z","timestamp":1788998400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2024_EKEA.149"],"award-info":[{"award-number":["2024_EKEA.149"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KR 4555\/9-1"],"award-info":[{"award-number":["KR 4555\/9-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["KR 4555\/10-1"],"award-info":[{"award-number":["KR 4555\/10-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbi.2026.107002","type":"journal-article","created":{"date-parts":[[2026,9,9]],"date-time":"2026-09-09T10:44:34Z","timestamp":1788950674000},"page":"107002","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["A psychometric evaluation of diffusion basis spectrum imaging indicates altered white matter microstructure consistent with elevated edema in depression"],"prefix":"10.1016","volume":"139","author":[{"given":"Luisa","family":"Kaluza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"K\u00fchnel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ekaterina","family":"Kuskova","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim","family":"Studener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise","family":"Rommel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jana","family":"Lieberz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9552-3781","authenticated-orcid":false,"given":"Nils B.","family":"Kroemer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.107002_b0005","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neubiorev.2017.08.019","article-title":"Treatment resistant depression: A multi-scale, systems biology approach","volume":"84","author":"Akil","year":"2018","journal-title":"Neuroscience and Biobehavioral Reviews"},{"issue":"3","key":"10.1016\/j.bbi.2026.107002_b0010","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1016\/j.nurt.2007.05.011","article-title":"Diffusion Tensor Imaging of the Brain","volume":"4","author":"Alexander","year":"2007","journal-title":"Neurotherapeutics, Advances in Neuroimaging\/Neuroethics"},{"issue":"2","key":"10.1016\/j.bbi.2026.107002_b0015","doi-asserted-by":"crossref","first-page":"870","DOI":"10.1016\/S1053-8119(03)00336-7","article-title":"How to correct susceptibility distortions in spin-echo echo-planar images: Application to diffusion tensor imaging","volume":"20","author":"Andersson","year":"2003","journal-title":"NeuroImage"},{"issue":"12","key":"10.1016\/j.bbi.2026.107002_b0020","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1002\/da.23294","article-title":"White matter alterations associated with lifetime and current depression in adolescents: Evidence for cingulum disruptions","volume":"39","author":"Barch","year":"2022","journal-title":"Depression and anxiety"},{"key":"10.1016\/j.bbi.2026.107002_b0025","doi-asserted-by":"crossref","unstructured":"Bekhbat, M., Li, Z., Mehta, N. D., Treadway, M. T., Lucido, M. J., Woolwine, B. J., Haroon, E., Miller, A. H., & Felger, J. C. (2022). Functional connectivity in reward circuitry and symptoms of anhedonia as therapeutic targets in depression with high inflammation: Evidence from a dopamine challenge study. Molecular Psychiatry, 27(10), Artikel 10. https:\/\/doi.org\/10.1038\/s41380-022-01715-3.","DOI":"10.1038\/s41380-022-01715-3"},{"key":"10.1016\/j.bbi.2026.107002_b0030","article-title":"Sustained effects of repeated levodopa (L-DOPA) administration on reward circuitry, effort-based motivation, and anhedonia in depressed patients with higher inflammation","author":"Bekhbat","year":"2024","journal-title":"Brain, Behavior, and Immunity."},{"issue":"3","key":"10.1016\/j.bbi.2026.107002_b0035","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1002\/hbm.20872","article-title":"Age\u2010related differences in multiple measures of white matter integrity: A diffusion tensor imaging study of healthy aging","volume":"31","author":"Bennett","year":"2009","journal-title":"Human Brain Mapping"},{"key":"10.1016\/j.bbi.2026.107002_b0040","doi-asserted-by":"crossref","first-page":"200","DOI":"10.1186\/1741-7015-11-200","article-title":"So depression is an inflammatory disease, but where does the inflammation come from?","volume":"11","author":"Berk","year":"2013","journal-title":"BMC Medicine"},{"key":"10.1016\/j.bbi.2026.107002_b0045","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.bbi.2021.01.016","article-title":"Elevated peripheral inflammation is associated with attenuated striatal reward anticipation in major depressive disorder","volume":"93","author":"Burrows","year":"2021","journal-title":"Brain, Behavior, and Immunity"},{"issue":"11","key":"10.1016\/j.bbi.2026.107002_b0050","doi-asserted-by":"crossref","first-page":"2384","DOI":"10.1038\/sj.npp.1301362","article-title":"Basal ganglia hypermetabolism and symptoms of fatigue during interferon-alpha therapy. Neuropsychopharmacology: Official Publication of the American College of","volume":"32","author":"Capuron","year":"2007","journal-title":"Neuropsychopharmacology"},{"issue":"10","key":"10.1016\/j.bbi.2026.107002_b0055","doi-asserted-by":"crossref","first-page":"1044","DOI":"10.1001\/archgenpsychiatry.2011.2094","article-title":"Dopaminergic mechanisms of reduced basal ganglia responses to hedonic reward during interferon alfa administration","volume":"69","author":"Capuron","year":"2012","journal-title":"Archives of General Psychiatry"},{"issue":"8","key":"10.1016\/j.bbi.2026.107002_b0060","doi-asserted-by":"crossref","first-page":"660","DOI":"10.1016\/j.biopsych.2025.06.026","article-title":"Impact of Inflammation on White Matter Integrity and Functional Connectivity in Chronic Major Depressive Disorder","volume":"99","author":"Cha","year":"2026","journal-title":"Biological Psychiatry"},{"issue":"2","key":"10.1016\/j.bbi.2026.107002_b0065","first-page":"123","article-title":"Central and Peripheral Inflammation Link Metabolic Syndrome and Major Depressive Disorder","volume":"34","author":"Chan","year":"2019","journal-title":"Physiology (Bethesda, Md.)"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0070","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1038\/s41380-024-02656-9","article-title":"PET imaging of neuroinflammation: Any credible alternatives to TSPO yet?","volume":"30","author":"Chauveau","year":"2025","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.bbi.2026.107002_b0075","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2025.120027","article-title":"The relationship between changes in white matter microstructure and cognition in untreated major depressive disorder","volume":"390","author":"Chen","year":"2025","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.bbi.2026.107002_b0080","article-title":"Test-Retest Reliability of Diffusion Tensor Imaging in Huntington\u2019s Disease. PLoS","volume":"6","author":"Cole","year":"2014","journal-title":"Currents"},{"key":"10.1016\/j.bbi.2026.107002_b0085","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2019.101710","article-title":"White matter abnormalities in depression: A categorical and phenotypic diffusion MRI study","volume":"22","author":"Coloigner","year":"2019","journal-title":"NeuroImage. Clinical"},{"key":"10.1016\/j.bbi.2026.107002_b0090","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.jneuroim.2016.10.002","article-title":"A new imaging modality to non-invasively assess multiple sclerosis pathology","volume":"40 Years-Neuroimmunology, 304","author":"Cross","year":"2017","journal-title":"Journal of Neuroimmunology, SI"},{"issue":"6","key":"10.1016\/j.bbi.2026.107002_b0095","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1017\/S003329171300158X","article-title":"Microstructural white-matter abnormalities associated with treatment resistance, severity and duration of illness in major depression","volume":"44","author":"de Diego-Adeli\u00f1o","year":"2014","journal-title":"Psychological Medicine"},{"issue":"3","key":"10.1016\/j.bbi.2026.107002_b0100","doi-asserted-by":"crossref","first-page":"968","DOI":"10.1016\/j.neuroimage.2006.01.021","article-title":"An automated labeling system for subdividing the human cerebral cortex on MRI scans into gyral based regions of interest","volume":"31","author":"Desikan","year":"2006","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0105","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1002\/oby.24188","article-title":"Relationships between abdominal adipose tissue and neuroinflammation with diffusion basis spectrum imaging in midlife obesity","volume":"33","author":"Dolatshahi","year":"2025","journal-title":"Obesity"},{"key":"10.1016\/j.bbi.2026.107002_b0110","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.pscychresns.2019.04.004","article-title":"Longitudinal diffusion weighted imaging of limbic regions in patients with major depressive disorder after 6 years and partial to full remission","volume":"287","author":"Doolin","year":"2019","journal-title":"Psychiatry Research: Neuroimaging"},{"issue":"8","key":"10.1016\/j.bbi.2026.107002_b0115","doi-asserted-by":"crossref","first-page":"748","DOI":"10.1016\/j.biopsych.2010.06.010","article-title":"Inflammation-induced anhedonia: Endotoxin reduces ventral striatum responses to reward","volume":"68","author":"Eisenberger","year":"2010","journal-title":"Biological Psychiatry"},{"key":"10.1016\/j.bbi.2026.107002_b0120","unstructured":"Eklund, A., & Trimble, J. (2021). beeswarm: The Bee Swarm Plot, an Alternative to Stripchart [Software]."},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0125","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: A robust preprocessing pipeline for functional MRI","volume":"16","author":"Esteban","year":"2019","journal-title":"Nature Methods"},{"issue":"11","key":"10.1016\/j.bbi.2026.107002_b0130","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1016\/j.biopsych.2007.05.026","article-title":"Effects of Interferon-alpha on Rhesus Monkeys: A Non-Human Primate Model of Cytokine-Induced Depression","volume":"62","author":"Felger","year":"2007","journal-title":"Biological psychiatry"},{"issue":"10","key":"10.1016\/j.bbi.2026.107002_b0135","doi-asserted-by":"crossref","first-page":"1358","DOI":"10.1038\/mp.2015.168","article-title":"Inflammation is associated with decreased functional connectivity within corticostriatal reward circuitry in depression","volume":"21","author":"Felger","year":"2016","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.bbi.2026.107002_b0140","first-page":"2179","volume":"38","author":"Felger","year":"2013","journal-title":"Chronic interferon-\u03b1 decreases dopamine 2 receptor binding and striatal dopamine release in association with anhedonia-like behavior in nonhuman primates"},{"key":"10.1016\/j.bbi.2026.107002_b0145","doi-asserted-by":"crossref","unstructured":"Felger, J. C., & Treadway, M. T. (2017). Inflammation Effects on Motivation and Motor Activity: Role of Dopamine. Neuropsychopharmacology, 42(1), Artikel 1. https:\/\/doi.org\/10.1038\/npp.2016.143.","DOI":"10.1038\/npp.2016.143"},{"issue":"14","key":"10.1016\/j.bbi.2026.107002_b0150","doi-asserted-by":"crossref","first-page":"3029","DOI":"10.1017\/S0033291720005073","article-title":"Non-invasive vagus nerve stimulation boosts mood recovery after effort exertion","volume":"52","author":"Ferstl","year":"2022","journal-title":"Psychological Medicine"},{"issue":"11","key":"10.1016\/j.bbi.2026.107002_b0155","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1038\/nn.4135","article-title":"Functional connectome fingerprinting: Identifying individuals using patterns of brain connectivity","volume":"18","author":"Finn","year":"2015","journal-title":"Nature Neuroscience"},{"key":"10.1016\/j.bbi.2026.107002_b0160","doi-asserted-by":"crossref","unstructured":"Friston, K., Ashburner, J., Kiebel, S., Nichols, T., & Penny, W. (2007). Statistical Parametric Mapping. Elsevier\/Academic Press.","DOI":"10.1016\/B978-012372560-8\/50002-4"},{"key":"10.1016\/j.bbi.2026.107002_b0165","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroimage.2019.03.053","article-title":"Addressing the reliability fallacy in fMRI: Similar group effects may arise from unreliable individual effects","volume":"195","author":"Fr\u00f6hner","year":"2019","journal-title":"NeuroImage"},{"key":"10.1016\/j.bbi.2026.107002_b0170","unstructured":"Garnier, S., Ross, N., Rudis, R., Carmago, A. P., Scaini, M., & Scherer, C. (2024). viridis(Lite)\u2014Colorblind-Friendly Color Maps for R. viridis package version 0.6.5.."},{"key":"10.1016\/j.bbi.2026.107002_b0175","doi-asserted-by":"crossref","unstructured":"Giollabhui, N. M., Madison, A. A., Lydston, M., Quang, E. L., Miller, A. H., & Liu, R. T. (2025). Effect of Anti-Inflammatory Treatment on Depressive Symptom Severity and Anhedonia in Depressed Individuals With Elevated Inflammation: Systematic Review and Meta-Analysis of Randomized Controlled Trials. American Journal of Psychiatry. (Washington, DC). https:\/\/psychiatryonline.org\/doi\/10.1176\/appi.ajp.20241115.","DOI":"10.1176\/appi.ajp.20241115"},{"issue":"4","key":"10.1016\/j.bbi.2026.107002_b0180","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1080\/08998280.2005.11928089","article-title":"Use of PET\/CT scanning in cancer patients: Technical and practical considerations","volume":"18","author":"Griffeth","year":"2005","journal-title":"Proceedings (Baylor University. Medical Center)"},{"key":"10.1016\/j.bbi.2026.107002_b0185","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1016\/j.jad.2021.06.001","article-title":"Neuroinflammation in Major Depressive Disorder: A Review of PET Imaging Studies Examining the 18-kDa Translocator Protein","volume":"292","author":"Gritti","year":"2021","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.bbi.2026.107002_b0190","doi-asserted-by":"crossref","first-page":"161","DOI":"10.1016\/j.jad.2024.07.050","article-title":"Intrinsic disruption of white matter microarchitecture in major depressive disorder: A voxel-based meta analysis of diffusion tensor imaging","volume":"363","author":"Guo","year":"2024","journal-title":"Journal of Affective Disorders"},{"key":"10.1016\/j.bbi.2026.107002_b0195","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1016\/j.bbi.2015.06.001","article-title":"Cumulative meta-analysis of interleukins 6 and 1\u03b2, tumour necrosis factor \u03b1 and C-reactive protein in patients with major depressive disorder","volume":"49","author":"Haapakoski","year":"2015","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.bbi.2026.107002_b0200","article-title":"Major depressive disorder shares systemic immune signatures and potential therapeutic targets with inflammatory skin diseases","volume":"1\u201311","author":"He","year":"2026","journal-title":"Molecular Psychiatry"},{"issue":"1126","key":"10.1016\/j.bbi.2026.107002_b0205","doi-asserted-by":"crossref","DOI":"10.1259\/bjr.20210388","article-title":"Cumulative radiation doses from recurrent PET\u2013CT examinations","volume":"94","author":"Hosono","year":"2021","journal-title":"The British Journal of Radiology"},{"issue":"8","key":"10.1016\/j.bbi.2026.107002_b0210","doi-asserted-by":"crossref","first-page":"1107","DOI":"10.2967\/jnumed.119.229443","article-title":"Neuroinflammation PET Imaging: Current Opinion and Future Directions","volume":"61","author":"Jain","year":"2020","journal-title":"Journal of Nuclear Medicine"},{"key":"10.1016\/j.bbi.2026.107002_b0215","doi-asserted-by":"crossref","unstructured":"Jenkinson, M., Beckmann, C. F., Behrens, T. E. J., Woolrich, M. W., & Smith, S. M. (2012). FSL. NeuroImage, 20 YEARS OF fMRI, 62(2), 782\u2013790. https:\/\/doi.org\/10.1016\/j.neuroimage.2011.09.015.","DOI":"10.1016\/j.neuroimage.2011.09.015"},{"issue":"2","key":"10.1016\/j.bbi.2026.107002_bib497","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/mrm.21823","article-title":"Magnetic field correlation as a measure of iron-generated magnetic field inhomogeneities in the brain","volume":"61","author":"Jensen","year":"2009","journal-title":"Magnetic Resonance in Medicine"},{"key":"10.1016\/j.bbi.2026.107002_b0220","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/j.neuroimage.2019.05.082","article-title":"Quantifying performance of machine learning methods for neuroimaging data","volume":"199","author":"Jollans","year":"2019","journal-title":"NeuroImage"},{"issue":"19","key":"10.1016\/j.bbi.2026.107002_b0225","doi-asserted-by":"crossref","first-page":"10535","DOI":"10.3390\/ijms251910535","article-title":"Inflammaging and Brain Aging","volume":"25","author":"Jurcau","year":"2024","journal-title":"International Journal of Molecular Sciences"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0230","doi-asserted-by":"crossref","first-page":"5407","DOI":"10.1038\/s41598-025-89581-1","article-title":"Magnetic resonance imaging signatures of neuroinflammation in major depressive disorder with religious and spiritual problems","volume":"15","author":"Kasz\u00e1s","year":"2025","journal-title":"Scientific Reports"},{"issue":"4","key":"10.1016\/j.bbi.2026.107002_b0235","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1016\/j.biopsych.2012.01.022","article-title":"Cingulum white matter in young women at risk of depression: The effect of family history and anhedonia","volume":"72","author":"Keedwell","year":"2012","journal-title":"Biological Psychiatry"},{"issue":"10","key":"10.1016\/j.bbi.2026.107002_b0240","doi-asserted-by":"crossref","DOI":"10.3390\/life15101599","article-title":"Diffusion Basis Restricted Fraction as a Putative Magnetic Resonance Imaging Marker of Neuroinflammation: Histological Evidence, Diagnostic Accuracy, and Translational Potential","volume":"15","author":"K\u00e9ri","year":"2025","journal-title":"Life"},{"key":"10.1016\/j.bbi.2026.107002_b0245","doi-asserted-by":"crossref","unstructured":"Khalife, S., Bollmann, S., Zalesky, A., & Oestreich, L. K. L. (2025). MRI-Derived Markers of Acute and Chronic Inflammatory Processes in the VTA Associated with Depression (S. 2025.04.30.651588). bioRxiv. https:\/\/doi.org\/10.1101\/2025.04.30.651588.","DOI":"10.1101\/2025.04.30.651588"},{"issue":"2","key":"10.1016\/j.bbi.2026.107002_b0250","first-page":"158","article-title":"Spatiotemporal Dynamics of Stress-Induced Network Reconfigurations Reflect Negative Affectivity","volume":"92","author":"K\u00fchnel","year":"2022","journal-title":"Biological Psychiatry, Molecular Mechanisms of Resilience and Vulnerability to Stress"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0255","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s42003-023-05396-8","article-title":"Stress-induced brain responses are associated with BMI in women","volume":"6","author":"K\u00fchnel","year":"2023","journal-title":"Communications Biology"},{"key":"10.1016\/j.bbi.2026.107002_b0260","doi-asserted-by":"crossref","unstructured":"K\u00fchnel, A., Zietz, J., Theuer, J., Neuser, M. P., Teckentrup, V., M\u00fcller, F. K., Dayan, P., Svaldi, J., & Kroemer, N. B. (2025). Dense sampling of choices links high learning rates to obesity and low reward sensitivity to binge eating (S. 2025.06.19.25329936). medRxiv. https:\/\/doi.org\/10.1101\/2025.06.19.25329936.","DOI":"10.1101\/2025.06.19.25329936"},{"issue":"13","key":"10.1016\/j.bbi.2026.107002_b0265","doi-asserted-by":"crossref","DOI":"10.18637\/jss.v082.i13","article-title":"lmerTest Package: Tests in Linear Mixed Effects Models","volume":"82","author":"Kuznetsova","year":"2017","journal-title":"Journal of Statistical Software"},{"key":"10.1016\/j.bbi.2026.107002_b0270","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jad.2022.06.043","article-title":"Association between peripheral inflammation and free-water imaging in Major Depressive Disorder before and after ketamine treatment \u2013 A pilot study","volume":"314","author":"Langhein","year":"2022","journal-title":"Journal of affective disorders"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0275","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1038\/s41398-025-03238-1","article-title":"Symptom-based depression subtypes: Brain dynamic specificity and its association with gene expression profiles","volume":"15","author":"Liang","year":"2025","journal-title":"Translational Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0280","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1503\/jpn.110180","article-title":"Is depression a disconnection syndrome? Meta-analysis of diffusion tensor imaging studies in patients with MDD","volume":"38","author":"Liao","year":"2013","journal-title":"Journal of Psychiatry & Neuroscience: JPN"},{"key":"10.1016\/j.bbi.2026.107002_b0285","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1016\/j.neuroimage.2014.12.035","article-title":"Reliability and statistical power analysis of cortical and subcortical FreeSurfer metrics in a large sample of healthy elderly","volume":"108","author":"Liem","year":"2015","journal-title":"NeuroImage"},{"key":"10.1016\/j.bbi.2026.107002_b0290","article-title":"Anhedonia correlates with functional connectivity of the nucleus accumbens subregions in patients with major depressive disorder","volume":"30","author":"Liu","year":"2021","journal-title":"NeuroImage : Clinical"},{"issue":"2","key":"10.1016\/j.bbi.2026.107002_b0295","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1002\/nbm.1020","article-title":"Three-dimensional characterization of non-gaussian water diffusion in humans using diffusion kurtosis imaging","volume":"19","author":"Lu","year":"2006","journal-title":"NMR in Biomedicine"},{"key":"10.1016\/j.bbi.2026.107002_b0300","doi-asserted-by":"crossref","DOI":"10.1016\/j.nicl.2020.102168","article-title":"Reproducibility, reliability and variability of FA and MD in the older healthy population: A test-retest multiparametric analysis","volume":"26","author":"Luque Laguna","year":"2020","journal-title":"NeuroImage. Clinical"},{"key":"10.1016\/j.bbi.2026.107002_bib498","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2147\/RMI.S369491","article-title":"Impact of Magnetic Field Inhomogeneity on the Quality of Magnetic Resonance Images and Compensation Techniques: A Review","volume":"15","author":"Manson","year":"2022","journal-title":"Reports in Medical Imaging"},{"issue":"12","key":"10.1016\/j.bbi.2026.107002_b0305","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1016\/S2215-0366(20)30255-8","article-title":"Neuroinflammation in psychiatric disorders: PET imaging and promising new targets","volume":"7","author":"Meyer","year":"2020","journal-title":"The lancet. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0310","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1038\/nri.2015.5","article-title":"The role of inflammation in depression: From evolutionary imperative to modern treatment target","volume":"16","author":"Miller","year":"2016","journal-title":"Nature Reviews. Immunology"},{"key":"10.1016\/j.bbi.2026.107002_b0315","doi-asserted-by":"crossref","DOI":"10.1162\/IMAG.a.1153","article-title":"TRAMFIX: TRavelling Across Melbourne for FIXel-based analysis (a reproducibility and reliability study)","volume":"4","author":"Mito","year":"2026","journal-title":"Imaging Neuroscience"},{"key":"10.1016\/j.bbi.2026.107002_b0320","doi-asserted-by":"crossref","DOI":"10.1016\/j.appet.2021.105813","article-title":"Acute vagus nerve stimulation does not affect liking or wanting ratings of food in healthy participants","volume":"169","author":"M\u00fcller","year":"2022","journal-title":"Appetite"},{"issue":"3","key":"10.1016\/j.bbi.2026.107002_b0325","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1038\/s41380-021-01413-6","article-title":"Genetic heterogeneity and subtypes of major depression","volume":"27","author":"Nguyen","year":"2022","journal-title":"Molecular Psychiatry"},{"issue":"7","key":"10.1016\/j.bbi.2026.107002_b0330","first-page":"638","article-title":"Transdiagnostic InVivo Magnetic Resonance Imaging Markers of Neuroinflammation","volume":"7","author":"Oestreich","year":"2022","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"key":"10.1016\/j.bbi.2026.107002_b0335","article-title":"Microstructural changes in the reward system are associated with post-stroke depression","volume":"28","author":"Oestreich","year":"2020","journal-title":"NeuroImage: Clinical"},{"key":"10.1016\/j.bbi.2026.107002_b0340","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.bbi.2020.02.010","article-title":"Inflammatory markers in depression: A meta-analysis of mean differences and variability in 5,166 patients and 5,083 controls","volume":"87","author":"Osimo","year":"2020","journal-title":"Brain, Behavior, and Immunity"},{"key":"10.1016\/j.bbi.2026.107002_b0345","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.jpsychires.2017.12.011","article-title":"The use of diffusional kurtosis imaging and neurite orientation dispersion and density imaging of the brain in major depressive disorder","volume":"98","author":"Ota","year":"2018","journal-title":"Journal of Psychiatric Research"},{"issue":"4","key":"10.1016\/j.bbi.2026.107002_b0350","doi-asserted-by":"crossref","first-page":"442","DOI":"10.1177\/1352458514546791","article-title":"Cingulum bundle alterations underlie subjective fatigue in multiple sclerosis","volume":"21","author":"Pardini","year":"2015","journal-title":"Multiple Sclerosis"},{"issue":"3","key":"10.1016\/j.bbi.2026.107002_b0355","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1002\/mrm.22055","article-title":"Free water elimination and mapping from diffusion MRI","volume":"62","author":"Pasternak","year":"2009","journal-title":"Magnetic Resonance in Medicine"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0360","doi-asserted-by":"crossref","DOI":"10.1038\/sdata.2018.63","article-title":"A high-resolution probabilistic in vivo atlas of human subcortical brain nuclei","volume":"5","author":"Pauli","year":"2018","journal-title":"Scientific Data"},{"key":"10.1016\/j.bbi.2026.107002_b0365","series-title":"R A Language and Environment for Statistical Computing. R Foundation for Statistical Computing","author":"R Core Team","year":"2024"},{"issue":"8","key":"10.1016\/j.bbi.2026.107002_b0370","doi-asserted-by":"crossref","first-page":"1328","DOI":"10.1002\/oby.23201","article-title":"Nucleus accumbens microstructure mediates the relationship between obesity and eating behavior in adults","volume":"29","author":"Samara","year":"2021","journal-title":"Obesity (Silver Spring, Md.)"},{"key":"10.1016\/j.bbi.2026.107002_b0375","doi-asserted-by":"crossref","first-page":"464","DOI":"10.3389\/fnhum.2019.00464","article-title":"Neuroinflammation and White Matter Alterations in Obesity Assessed by Diffusion Basis Spectrum Imaging","volume":"13","author":"Samara","year":"2019","journal-title":"Frontiers in Human Neuroscience"},{"key":"10.1016\/j.bbi.2026.107002_b0380","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2022.119138","article-title":"Accuracy and reliability of diffusion imaging models","volume":"254","author":"Seider","year":"2022","journal-title":"NeuroImage"},{"issue":"2","key":"10.1016\/j.bbi.2026.107002_b0385","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.bbr.2008.09.038","article-title":"Ventral Pallidum Roles in Reward and Motivation","volume":"196","author":"Smith","year":"2009","journal-title":"Behavioural brain research"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0390","doi-asserted-by":"crossref","first-page":"10357","DOI":"10.1038\/s41467-025-65345-3","article-title":"Ventral tegmental area GABA neurons integrate positive and negative valence","volume":"16","author":"Stelzner","year":"2025","journal-title":"Nature Communications"},{"key":"10.1016\/j.bbi.2026.107002_bib496","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.neuroimage.2017.06.013","article-title":"In vivo B0 field shimming methods for MRI at 7 T","volume":"168","author":"Stockmann","year":"2018","journal-title":"NeuroImage"},{"key":"10.1016\/j.bbi.2026.107002_b0395","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.jpsychires.2025.02.007","article-title":"Abnormal neuritic microstructures in the anterior limb of internal capsules in treatment-resistant depression\u2014A cross-sectional NODDI study","volume":"183","author":"Takahashi","year":"2025","journal-title":"Journal of Psychiatric Research"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0400","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1177\/875647939000600106","article-title":"Interpretation of the Correlation Coefficient: A Basic Review","volume":"6","author":"Taylor","year":"1990","journal-title":"Journal of Diagnostic Medical Sonography"},{"key":"10.1016\/j.bbi.2026.107002_b0405","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2021.118679","article-title":"Brain signaling dynamics after vagus nerve stimulation","volume":"245","author":"Teckentrup","year":"2021","journal-title":"NeuroImage"},{"issue":"21","key":"10.1016\/j.bbi.2026.107002_b0410","doi-asserted-by":"crossref","first-page":"4987","DOI":"10.3390\/jcm10214987","article-title":"Same Brain, Different Look?-The Impact of Scanner, Sequence and Preprocessing on Diffusion Imaging Outcome Parameters","volume":"10","author":"Thieleking","year":"2021","journal-title":"Journal of Clinical Medicine"},{"key":"10.1016\/j.bbi.2026.107002_b0415","doi-asserted-by":"crossref","unstructured":"Thomas, M., Savitz, J., Zhang, Y., Burrows, K., Smith, R., Figueroa-Hall, L., Kuplicki, R., Khalsa, S. S., Taki, Y., Teague, T. K., Irwin, M. R., Yeh, F.-C., Paulus, M. P., Zheng, H., & on behalf of Tulsa 1000 Investigators. (2022). Elevated Systemic Inflammation Is Associated with Reduced Corticolimbic White Matter Integrity in Depression. Life, 12(1), 43. https:\/\/doi.org\/10.3390\/life12010043.","DOI":"10.3390\/life12010043"},{"key":"10.1016\/j.bbi.2026.107002_b0420","article-title":"A randomized proof-of-mechanism trial of TNF antagonism for motivational deficits and related corticostriatal circuitry in depressed patients with high inflammation","volume":"1\u201311","author":"Treadway","year":"2024","journal-title":"Molecular Psychiatry"},{"issue":"7","key":"10.1016\/j.bbi.2026.107002_b0425","doi-asserted-by":"crossref","first-page":"1511","DOI":"10.1038\/s41380-019-0477-2","article-title":"White matter disturbances in major depressive disorder: A coordinated analysis across 20 international cohorts in the ENIGMA MDD working group","volume":"25","author":"van Velzen","year":"2020","journal-title":"Molecular Psychiatry"},{"key":"10.1016\/j.bbi.2026.107002_b0430","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.neuroimage.2015.07.069","article-title":"Inscapes: A movie paradigm to improve compliance in functional magnetic resonance imaging","volume":"122","author":"Vanderwal","year":"2015","journal-title":"NeuroImage"},{"key":"10.1016\/j.bbi.2026.107002_b0435","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbi.2025.03.001","article-title":"Inflammation and metabolic dysfunction underly anhedonia-like behavior in antidepressant resistant male rats","volume":"127","author":"Varela","year":"2025","journal-title":"Brain, Behavior, and Immunity"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0440","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.neuroimage.2009.01.058","article-title":"The role of the nucleus accumbens and rostral anterior cingulate cortex in anhedonia: Integration of resting EEG, fMRI, and volumetric techniques","volume":"46","author":"Wacker","year":"2009","journal-title":"NeuroImage"},{"key":"10.1016\/j.bbi.2026.107002_b0445","first-page":"116","volume":"eBioMedicine","author":"Wang","year":"2025","journal-title":"Unveiling diverse clinical symptom patterns and neural activity profiles in major depressive disorder subtypes."},{"issue":"12","key":"10.1016\/j.bbi.2026.107002_b0450","doi-asserted-by":"crossref","first-page":"3587","DOI":"10.1093\/brain\/awr307","article-title":"Quantification of increased cellularity during inflammatory demyelination","volume":"134","author":"Wang","year":"2011","journal-title":"Brain"},{"key":"10.1016\/j.bbi.2026.107002_b0455","doi-asserted-by":"crossref","unstructured":"Wickham, H. (2016). ggplot2: Elegant Graphics for Data Analysis [Software].","DOI":"10.1007\/978-3-319-24277-4_9"},{"key":"10.1016\/j.bbi.2026.107002_b0460","unstructured":"Wilke, C. O. (2024). cowplot: Streamlined Plot Theme and Plot Annotations for \u201eggplot2\u201c [Software]."},{"issue":"3","key":"10.1016\/j.bbi.2026.107002_b0465","article-title":"Test-retest reliability of diffusion kurtosis imaging metrics in the healthy adult brain","volume":"2","author":"Wu","year":"2022","journal-title":"Neuroimage: Reports"},{"key":"10.1016\/j.bbi.2026.107002_b0470","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2020.117329","article-title":"Shape analysis of the human association pathways","volume":"223","author":"Yeh","year":"2020","journal-title":"NeuroImage"},{"issue":"1","key":"10.1016\/j.bbi.2026.107002_b0475","doi-asserted-by":"crossref","first-page":"4933","DOI":"10.1038\/s41467-022-32595-4","article-title":"Population-based tract-to-region connectome of the human brain and its hierarchical topology","volume":"13","author":"Yeh","year":"2022","journal-title":"Nature Communications"},{"issue":"11","key":"10.1016\/j.bbi.2026.107002_b0480","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0080713","article-title":"Deterministic Diffusion Fiber Tracking Improved by Quantitative Anisotropy","volume":"8","author":"Yeh","year":"2013","journal-title":"PLOS ONE"},{"issue":"4","key":"10.1016\/j.bbi.2026.107002_b0485","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/j.neuroimage.2012.03.072","article-title":"NODDI: Practical in vivo neurite orientation dispersion and density imaging of the human brain","volume":"61","author":"Zhang","year":"2012","journal-title":"NeuroImage"},{"issue":"9","key":"10.1016\/j.bbi.2026.107002_b0490","first-page":"967","article-title":"Neuroinflammation in the Amygdala Is Associated With Recent Depressive Symptoms","volume":"8","author":"Zhang","year":"2023","journal-title":"Biological Psychiatry: Cognitive Neuroscience and Neuroimaging"},{"issue":"3","key":"10.1016\/j.bbi.2026.107002_b0495","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70416","article-title":"Microstructure Abnormalities of Diffusion Tensor Imaging Measures in First-Episode, Treatment-Na\u00efve Adolescents With Major Depressive Disorder: An Integrated AFQ and TBSS Study","volume":"15","author":"Zhang","year":"2025","journal-title":"Brain and Behavior"}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126007506?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126007506?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T23:10:42Z","timestamp":1790896242000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126007506"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":102,"alternative-id":["S0889159126007506"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.107002","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A psychometric evaluation of diffusion basis spectrum imaging indicates altered white matter microstructure consistent with elevated edema in depression","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.107002","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"107002"}}