{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T17:50:27Z","timestamp":1791568227449,"version":"4.3.4"},"reference-count":73,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,1,1]],"date-time":"2027-01-01T00:00:00Z","timestamp":1798761600000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82473629"],"award-info":[{"award-number":["82473629"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012246","name":"Priority Academic Program Development of Jiangsu Higher Education Institutions","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012246","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100012659","name":"Foundation for Innovative Research Groups of the National Natural Science Foundation of China","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100012659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2027,1]]},"DOI":"10.1016\/j.bbi.2026.107042","type":"journal-article","created":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T23:40:49Z","timestamp":1791243649000},"page":"107042","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Dietary advanced glycation end products are associated with anxiety- and depression-like behavior in male mice via gut microbiota mediated disruption of tryptophan metabolism"],"prefix":"10.1016","volume":"139","author":[{"given":"Guoqi","family":"Yang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yebing","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mengru","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dengping","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yu","family":"Xia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Runxiong","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lili","family":"Xin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li-Qiang","family":"Qin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6297-5933","authenticated-orcid":false,"given":"Zhongxiao","family":"Wan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbi.2026.107042_b0005","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1016\/j.chom.2018.05.003","article-title":"Gut Microbiota Regulation of Tryptophan Metabolism in Health and Disease","volume":"23","author":"Agus","year":"2018","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbi.2026.107042_b0010","doi-asserted-by":"crossref","DOI":"10.1002\/cph4.70100","article-title":"The Microbiota-Gut-Brain Axis in the Pathophysiology of Major Depressive Disorder: a Mechanistic Review","volume":"16","author":"Akif","year":"2026","journal-title":"Compr. Physiol."},{"key":"10.1016\/j.bbi.2026.107042_b0015","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1038\/s41423-020-00585-5","article-title":"The aryl hydrocarbon receptor and the gut-brain axis","volume":"18","author":"Barroso","year":"2021","journal-title":"Cell. Mol. Immunol."},{"key":"10.1016\/j.bbi.2026.107042_b0020","series-title":"Frontiers in Neuroscience. Methods of Behavior Analysis in Neuroscience","year":"2009"},{"key":"10.1016\/j.bbi.2026.107042_b0025","doi-asserted-by":"crossref","DOI":"10.3390\/nu14163384","article-title":"The effect of Short-Term Consumption of Lactic Acid Bacteria on the Gut Microbiota in Obese People","volume":"14","author":"Burakova","year":"2022","journal-title":"Nutrients"},{"key":"10.1016\/j.bbi.2026.107042_b0030","doi-asserted-by":"crossref","DOI":"10.3390\/ijms27010465","volume":"27","author":"Chehadi","year":"2026","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.107042_b0035","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/bs.acc.2019.08.005","article-title":"Tryptophan in health and disease","volume":"95","author":"Comai","year":"2020","journal-title":"Adv. Clin. Chem."},{"key":"10.1016\/j.bbi.2026.107042_b0040","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1186\/s12916-024-03248-8","article-title":"Dysfunction in endocannabinoids, palmitoylethanolamide, and degradation of tryptophan into kynurenine in individuals with depressive symptoms","volume":"22","author":"Comai","year":"2024","journal-title":"BMC Med."},{"key":"10.1016\/j.bbi.2026.107042_b0045","doi-asserted-by":"crossref","first-page":"1877","DOI":"10.1152\/physrev.00018.2018","article-title":"The Microbiota-Gut-Brain Axis","volume":"99","author":"Cryan","year":"2019","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbi.2026.107042_b0050","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2026.107042_b0055","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1038\/s41366-021-01049-0","article-title":"Association between the indole pathway of tryptophan metabolism and subclinical depressive symptoms in obesity: a preliminary study","volume":"46","author":"Delgado","year":"2022","journal-title":"Int. J. Obes. (Lond)"},{"key":"10.1016\/j.bbi.2026.107042_b0060","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2020.1869501","article-title":"Involvement of the microbiota-gut-brain axis in chronic restraint stress: disturbances of the kynurenine metabolic pathway in both the gut and brain","volume":"13","author":"Deng","year":"2021","journal-title":"Gut Microbes"},{"issue":"2591\u2013602","key":"10.1016\/j.bbi.2026.107042_b0065","first-page":"e8","article-title":"Advanced Glycation End Products Promote Melanogenesis by Activating NLRP3 Inflammasome in Human Dermal Fibroblasts","volume":"142","author":"Fang","year":"2022","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbi.2026.107042_b0070","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1177\/0023677217738268","article-title":"On determining sample size in experiments involving laboratory animals","volume":"52","author":"Festing","year":"2018","journal-title":"Lab Anim."},{"key":"10.1016\/j.bbi.2026.107042_b0075","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41398-023-02670-5","article-title":"Gut microbiota composition in depressive disorder: a systematic review, meta-analysis, and meta-regression","volume":"13","author":"Gao","year":"2023","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbi.2026.107042_b0080","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.coph.2019.08.004","article-title":"Focus on the essentials: tryptophan metabolism and the microbiome-gut-brain axis","volume":"48","author":"Gheorghe","year":"2019","journal-title":"Curr. Opin. Pharmacol."},{"key":"10.1016\/j.bbi.2026.107042_b0085","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.653208","article-title":"Amino Acid Trp: the Far out Impacts of host and Commensal Tryptophan Metabolism","volume":"12","author":"Grifka-Walk","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbi.2026.107042_b0090","doi-asserted-by":"crossref","DOI":"10.1021\/acs.jafc.4c00365","article-title":"Bifidobacterium bifidum Ameliorates DSS-Induced Colitis in mice by Regulating Microbial Metabolome and Targeting Gut Microbiota","author":"Han","year":"2024","journal-title":"J. Agric. Food Chem."},{"key":"10.1016\/j.bbi.2026.107042_b0095","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1159\/000371679","article-title":"Relationship between Obesity, Gut Microbiome and Hepatocellular Carcinoma Development","volume":"33","author":"Hara","year":"2015","journal-title":"Dig. Dis."},{"key":"10.1016\/j.bbi.2026.107042_b0100","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2026.103055","article-title":"Neuroimmune dysregulation in Alzheimer's disease: Mechanisms and therapeutic strategies","volume":"117","author":"He","year":"2026","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbi.2026.107042_b0105","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1080\/10408444.2024.2362985","article-title":"Dietary glycation compounds - implications for human health","volume":"54","author":"Hellwig","year":"2024","journal-title":"Crit. Rev. Toxicol."},{"key":"10.1016\/j.bbi.2026.107042_b0110","doi-asserted-by":"crossref","DOI":"10.3390\/nu18030507","article-title":"Serotonin, Kynurenine, and Indole Pathways of Tryptophan Metabolism in Humans in Health and Disease","volume":"18","author":"Holecek","year":"2026","journal-title":"Nutrients"},{"key":"10.1016\/j.bbi.2026.107042_b0115","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines14010026","article-title":"Potential Impact of Microbial Dysbiosis and Tryptophan Metabolites in Advanced Stages of Colorectal Cancer","volume":"14","author":"Hulin","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbi.2026.107042_b0120","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2019.100815","article-title":"You've got male: sex and the microbiota-gut-brain axis across the lifespan","volume":"56","author":"Jaggar","year":"2020","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bbi.2026.107042_b0125","series-title":"Khan MAB","first-page":"22","author":"Khalid","year":"2021"},{"key":"10.1016\/j.bbi.2026.107042_b0130","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2020.105083","article-title":"The importance of BDNF and RAGE in diabetes-induced dementia","volume":"160","author":"Kim","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbi.2026.107042_b0135","doi-asserted-by":"crossref","first-page":"48","DOI":"10.5534\/wjmh.190009","article-title":"Sex differences in Gut Microbiota","volume":"38","author":"Kim","year":"2020","journal-title":"World J Mens Health"},{"key":"10.1016\/j.bbi.2026.107042_b0140","doi-asserted-by":"crossref","DOI":"10.1016\/j.jep.2025.119393","article-title":"Biotransformation of Ganoderma lucidum and Hericium erinaceus for ex vivo gut-brain axis modulation and mood-related outcomes in humans: CREB\/BDNF signaling and microbiota-driven synergies","volume":"342","author":"Koszla","year":"2025","journal-title":"J. Ethnopharmacol."},{"key":"10.1016\/j.bbi.2026.107042_b0145","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1111\/j.1365-2826.2008.01772.x","article-title":"Behavioural assays to model cognitive and affective dimensions of depression and anxiety in rats","volume":"20","author":"Lapiz-Bluhm","year":"2008","journal-title":"J. Neuroendocrinol."},{"key":"10.1016\/j.bbi.2026.107042_b0150","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1111\/hel.12174","article-title":"Enhanced expression of indoleamine 2,3-dioxygenase in Helicobacter pylori-infected human gastric mucosa modulates Th1\/Th2 pathway and interleukin 17 production","volume":"20","author":"Larussa","year":"2015","journal-title":"Helicobacter"},{"key":"10.1016\/j.bbi.2026.107042_b0155","doi-asserted-by":"crossref","first-page":"1400","DOI":"10.1016\/j.neurobiolaging.2011.02.003","article-title":"AGEs induce Alzheimer-like tau pathology and memory deficit via RAGE-mediated GSK-3 activation","volume":"33","author":"Li","year":"2012","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbi.2026.107042_b0160","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1379064","article-title":"Multi-omics analysis of the biological mechanism of the pathogenesis of non-alcoholic fatty liver disease","volume":"15","author":"Lin","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbi.2026.107042_b0165","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1186\/s13020-025-01304-w","article-title":"Multi-omics reveals an association of the gut butyrate-IDO1-tryptophan axis with Yinchenhaotang plus Zexietang-ameliorated NASH in a microbiota-dependent manner","volume":"21","author":"Liu","year":"2026","journal-title":"Chin. Med."},{"key":"10.1016\/j.bbi.2026.107042_b0170","doi-asserted-by":"crossref","DOI":"10.1016\/j.jad.2026.121243","article-title":"Global, regional, and national burden of five major mental disorders in working-age population, 1990-2021: a systematic analysis for the Global Burden of Disease Study 2021","volume":"403","author":"Luo","year":"2026","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2026.107042_b0175","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s11011-024-01450-4","article-title":"Integrated colon microbiome and metabolomics to elucidate the antidepressant mechanisms of the Radix Bupleuri-Radix Paeoniae Alba herb pair","volume":"40","author":"Lv","year":"2024","journal-title":"Metab. Brain Dis."},{"key":"10.1016\/j.bbi.2026.107042_b0180","article-title":"Dietary Advanced Glycation End Products Induced Anxiety- and Depression-like Behaviors in Female C57BL\/6 mice and the Ameliorative Effects of Quercetin","volume":"110363","author":"Ma","year":"2026","journal-title":"J. Nutr. Biochem."},{"key":"10.1016\/j.bbi.2026.107042_b0185","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2026.157772","article-title":"Advanced glycation end products (AGEs) and in vitro and in vivo approaches to study their mechanisms of action and the protective properties of natural compounds","volume":"150","author":"Martati","year":"2026","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbi.2026.107042_b0190","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1186\/s12916-025-04002-4","article-title":"The risk associated with ultra-processed food intake on depressive symptoms and mental health in older adults: a target trial emulation","volume":"23","author":"Mengist","year":"2025","journal-title":"BMC Med."},{"key":"10.1016\/j.bbi.2026.107042_b0195","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1111\/j.1601-183X.2006.00249.x","article-title":"Estrous cycle effects on behavior of C57BL\/6J and BALB\/cByJ female mice: implications for phenotyping strategies","volume":"6","author":"Meziane","year":"2007","journal-title":"Genes Brain Behav."},{"key":"10.1016\/j.bbi.2026.107042_b0200","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.actbio.2021.12.026","article-title":"Macrophage membrane-functionalized nanofibrous mats and their immunomodulatory effects on macrophage polarization","volume":"141","author":"Nakkala","year":"2022","journal-title":"Acta Biomater."},{"key":"10.1016\/j.bbi.2026.107042_b0205","doi-asserted-by":"crossref","first-page":"624","DOI":"10.1016\/j.jad.2023.07.078","article-title":"The kynurenine pathway in major depressive disorder under different disease states: a systematic review and meta-analysis","volume":"339","author":"Ou","year":"2023","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbi.2026.107042_b0210","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24066010","article-title":"Sex differences in Tryptophan Metabolism: a Systematic Review Focused on Neuropsychiatric Disorders","volume":"24","author":"Pais","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.107042_b0215","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1038\/s41573-019-0016-5","article-title":"Tryptophan metabolism as a common therapeutic target in cancer, neurodegeneration and beyond","volume":"18","author":"Platten","year":"2019","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbi.2026.107042_b0220","doi-asserted-by":"crossref","first-page":"978","DOI":"10.1124\/pharmrev.124.000239","article-title":"Neuroactive Kynurenines as Pharmacological Targets: New Experimental Tools and Exciting Therapeutic Opportunities","volume":"76","author":"Pocivavsek","year":"2024","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbi.2026.107042_b0225","article-title":"Bifidobacteria with indole-3-lactic acid-producing capacity exhibit psychobiotic potential via reducing neuroinflammation","volume":"5","author":"Qian","year":"2024","journal-title":"Cell Rep. Med."},{"key":"10.1016\/j.bbi.2026.107042_b0230","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201700118","article-title":"Dietary advanced glycation end products modify gut microbial composition and partially increase colon permeability in rats","volume":"61","author":"Qu","year":"2017","journal-title":"Mol. Nutr. Food Res."},{"key":"10.1016\/j.bbi.2026.107042_b0235","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1007\/s12031-024-02297-1","article-title":"Advanced Glycation End Products in Neurodegenerative Diseases","volume":"74","author":"Raghavan","year":"2024","journal-title":"J. Mol. Neurosci."},{"key":"10.1016\/j.bbi.2026.107042_b0240","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbi.2019.03.006","article-title":"Monchaux de Oliveira C, Helbling JC, L\u00e9vy \u00c9, Chevalier G, Leboyer M, Eberl G, Lay\u00e9 S, Capuron L, Vergnolle N, Neunlist M, Boudin H, Lepage P, Darnaud\u00e9ry M: Multi-hit early life adversity affects gut microbiota, brain and behavior in a sex-dependent manner","volume":"80","author":"Rincel","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.107042_b0245","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/s41564-023-01564-y","article-title":"The gut virome is associated with stress-induced changes in behaviour and immune responses in mice","volume":"9","author":"Ritz","year":"2024","journal-title":"Nat. Microbiol."},{"key":"10.1016\/j.bbi.2026.107042_b0250","series-title":"Ge Y","first-page":"22","author":"Roth","year":"2021"},{"key":"10.1016\/j.bbi.2026.107042_b0255","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1038\/s41577-019-0125-8","article-title":"The aryl hydrocarbon receptor: an environmental sensor integrating immune responses in health and disease","volume":"19","author":"Rothhammer","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2026.107042_b0260","doi-asserted-by":"crossref","DOI":"10.1016\/j.numecd.2025.104538","article-title":"Dietary Advanced Glycation End Products (dAGEs): Pathogenesis and nutritional strategies for health longevity-a critical view","volume":"36","author":"Russo","year":"2026","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"10.1016\/j.bbi.2026.107042_b0265","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s13293-023-00490-2","article-title":"Interaction between gut microbiota and sex hormones and their relation to sexual dimorphism in metabolic diseases","volume":"14","author":"Santos-Marcos","year":"2023","journal-title":"Biol. Sex Differ."},{"key":"10.1016\/j.bbi.2026.107042_b0270","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1038\/s41380-019-0414-4","article-title":"The kynurenine pathway: a finger in every pie","volume":"25","author":"Savitz","year":"2020","journal-title":"Mol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.107042_b0275","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1016\/j.clnu.2019.12.011","article-title":"Association between dietary patterns and adult depression symptoms based on principal component analysis, reduced-rank regression and partial least-squares","volume":"39","author":"Shakya","year":"2020","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.bbi.2026.107042_b0280","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1016\/j.bbi.2016.03.002","article-title":"Indoleamine-2,3-dioxygenase mediates neurobehavioral alterations induced by an intracerebroventricular injection of amyloid-beta1-42 peptide in mice","volume":"56","author":"Souza","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.107042_b0285","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbi.2022.08.003","article-title":"Microbiota-derived metabolite Indoles induced aryl hydrocarbon receptor activation and inhibited neuroinflammation in APP\/PS1 mice","volume":"106","author":"Sun","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.107042_b0290","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1038\/s41577-019-0165-0","article-title":"The NLRP3 inflammasome: molecular activation and regulation to therapeutics","volume":"19","author":"Swanson","year":"2019","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbi.2026.107042_b0295","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2147\/DMSO.S346411","article-title":"Dietary Advanced Glycation End Products Shift the Gut Microbiota Composition and Induce Insulin Resistance in mice","volume":"15","author":"Wang","year":"2022","journal-title":"Diabetes Metab Syndr Obes"},{"key":"10.1016\/j.bbi.2026.107042_b0300","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.bbi.2021.06.003","article-title":"Exploring the microbiota-Alzheimer's disease linkage using short-term antibiotic treatment followed by fecal microbiota transplantation","volume":"96","author":"Wang","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbi.2026.107042_b0305","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s40168-024-01750-y","article-title":"Microbiota-derived indoles alleviate intestinal inflammation and modulate microbiome by microbial cross-feeding","volume":"12","author":"Wang","year":"2024","journal-title":"Microbiome"},{"key":"10.1016\/j.bbi.2026.107042_b0310","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2025.2470386","article-title":"Indole derivatives ameliorated the methamphetamine-induced depression and anxiety via aryl hydrocarbon receptor along \u201cmicrobiota-brain\u201d axis","volume":"17","author":"Wang","year":"2025","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bbi.2026.107042_b0315","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2026.178720","article-title":"Gut microbiota-derived indole metabolites in depression: mechanisms and therapeutic potential","volume":"1019","author":"Wang","year":"2026","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbi.2026.107042_b0320","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.jchromb.2019.02.021","article-title":"LC-MS\/MS-based quantification of tryptophan metabolites and neurotransmitters in the serum and brain of mice","volume":"1112","author":"Wang","year":"2019","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbi.2026.107042_b0325","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1186\/s40168-023-01635-6","article-title":"Multi-omics reveal microbial determinants impacting the treatment outcome of antidepressants in major depressive disorder","volume":"11","author":"Wang","year":"2023","journal-title":"Microbiome"},{"key":"10.1016\/j.bbi.2026.107042_b0330","doi-asserted-by":"crossref","first-page":"6198","DOI":"10.1038\/s41467-022-34054-6","article-title":"Reduced alcohol preference and intake after fecal transplant in patients with alcohol use disorder is transmissible to germ-free mice","volume":"13","author":"Wolstenholme","year":"2022","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbi.2026.107042_b0335","doi-asserted-by":"crossref","first-page":"9024","DOI":"10.1039\/D4FO01545B","article-title":"Unveiling the dynamic processes of dietary advanced glycation end-products (dAGEs) in absorption, accumulation, and gut microbiota metabolism","volume":"15","author":"Wu","year":"2024","journal-title":"Food Funct."},{"key":"10.1016\/j.bbi.2026.107042_b0340","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2026.108158","article-title":"Lactobacillus johnsonii and 3-indolepropionic acid improve the depression-like behaviors via inhibiting neuroinflammation","volume":"226","author":"Xie","year":"2026","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbi.2026.107042_b0345","doi-asserted-by":"crossref","DOI":"10.3390\/cells14050384","article-title":"Tryptophan and its Metabolite Serotonin Impact Metabolic and Mental Disorders via the Brain-Gut-Microbiome Axis: a Focus on sex differences","volume":"14","author":"Xu","year":"2025","journal-title":"Cells"},{"key":"10.1016\/j.bbi.2026.107042_b0350","doi-asserted-by":"crossref","DOI":"10.1128\/msystems.01027-23","article-title":"New aspects characterizing non-obese NAFLD by the analysis of the intestinal flora and metabolites using a mouse model","volume":"9","author":"Zhang","year":"2024","journal-title":"mSystems"},{"key":"10.1016\/j.bbi.2026.107042_b0355","doi-asserted-by":"crossref","first-page":"296","DOI":"10.1007\/s00394-025-03818-3","article-title":"Associations of dietary advanced glycation end products and the risk of depression and anxiety","volume":"64","author":"Zhang","year":"2025","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.bbi.2026.107042_b0360","article-title":"Dietary advanced glycation products combined with chronic restraint stress induced anxiety-like and depression-like behaviors in male mice. NPJ Sci","author":"Zhang","year":"2026","journal-title":"Food"},{"key":"10.1016\/j.bbi.2026.107042_b0365","doi-asserted-by":"crossref","first-page":"E203","DOI":"10.1152\/ajpendo.00037.2020","article-title":"Fecal microbiota transplantation from high caloric-fed donors alters glucose metabolism in recipient mice, independently of adiposity or exercise status","volume":"319","author":"Zoll","year":"2020","journal-title":"Am. J. Phys. Endocrinol. Metab."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126007907?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126007907?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,9]],"date-time":"2026-10-09T16:54:57Z","timestamp":1791564897000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126007907"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,1]]},"references-count":73,"alternative-id":["S0889159126007907"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.107042","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2027,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Dietary advanced glycation end products are associated with anxiety- and depression-like behavior in male mice via gut microbiota mediated disruption of tryptophan metabolism","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.107042","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107042"}}