{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T12:31:41Z","timestamp":1793449901930,"version":"4.5.0"},"reference-count":123,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-017"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-037"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-012"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-029"},{"start":{"date-parts":[[2027,2,1]],"date-time":"2027-02-01T00:00:00Z","timestamp":1801440000000},"content-version":"stm-asf","delay-in-days":0,"URL":"https:\/\/doi.org\/10.15223\/policy-004"}],"funder":[{"DOI":"10.13039\/501100003803","name":"The University of Hong Kong","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003803","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, and Immunity"],"published-print":{"date-parts":[[2027,2]]},"DOI":"10.1016\/j.bbi.2026.107077","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T16:09:01Z","timestamp":1792166941000},"page":"107077","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Melatonin ameliorates behavioral deficits in 5xFAD mice through modulation of neurogenesis, neuroimmune responses, neurotransmission, and metabolic pathways"],"prefix":"10.1016","volume":"140","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8934-738X","authenticated-orcid":false,"given":"Jaydeep","family":"Roy","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ka Chun","family":"Tsui","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chi Him","family":"Poon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0003-6497-3848","authenticated-orcid":false,"given":"Jingyi","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yunfan","family":"Lai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kan Yin","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mazel","family":"Mihardja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vera","family":"Tse","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pui Ching","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching","family":"Au","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jonah","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ersoy","family":"Kocabicak","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luca","family":"Aquili","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kah Hui","family":"Wong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiliang","family":"Lu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasin","family":"Temel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Man Lung","family":"Fung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6692-6285","authenticated-orcid":false,"given":"Lee Wei","family":"Lim","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0565","doi-asserted-by":"crossref","first-page":"1631","DOI":"10.1007\/s12035-024-04333-y","article-title":"An Expanded Narrative Review of Neurotransmitters on Alzheimer's Disease: the Role of Therapeutic Interventions on Neurotransmission","volume":"62","author":"Akyuz","year":"2025","journal-title":"Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.bbi.2026.107077_b0065","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1038\/s41419-021-04237-y","article-title":"Hippocampal disruptions of synaptic and astrocyte metabolism are primary events of early amyloid pathology in the 5xFAD mouse model of Alzheimer's disease","volume":"12","author":"Andersen","year":"2021","journal-title":"Cell Death Dis."},{"issue":"9770","key":"10.1016\/j.bbi.2026.107077_b0005","doi-asserted-by":"crossref","first-page":"1019","DOI":"10.1016\/S0140-6736(10)61349-9","article-title":"Alzheimer's disease. the","volume":"377","author":"Ballard","year":"2011","journal-title":"Lancet"},{"issue":"11","key":"10.1016\/j.bbi.2026.107077_b0435","doi-asserted-by":"crossref","first-page":"e674","DOI":"10.1038\/tp.2015.166","article-title":"Neuroplasticity-dependent and -independent mechanisms of chronic deep brain stimulation in stressed rats","volume":"5","author":"Bambico","year":"2015","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0200","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Roy. Stat. Soc.: Ser. B (Methodol.)"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0305","doi-asserted-by":"crossref","first-page":"8965","DOI":"10.1038\/s41598-017-08121-8","article-title":"Classification of M1\/M2-polarized human macrophages by label-free hyperspectral reflectance confocal microscopy and multivariate analysis","volume":"7","author":"Bertani","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0215","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1523\/JNEUROSCI.4800-06.2007","article-title":"Learning decreases a beta*56 and tau pathology and ameliorates behavioral decline in 3xTg-AD mice","volume":"27","author":"Billings","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.107077_b0420","doi-asserted-by":"crossref","first-page":"55","DOI":"10.3389\/fnbeh.2019.00055","article-title":"Deficits in Social Behavior Precede Cognitive Decline in Middle-Aged mice","volume":"13","author":"Boyer","year":"2019","journal-title":"Front. Behav. Neurosci."},{"issue":"17","key":"10.1016\/j.bbi.2026.107077_b0150","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27175543","article-title":"Chronic Treatment with Melatonin Improves Hippocampal Neurogenesis in the Aged Brain and under Neurodegeneration","volume":"27","author":"Cach\u00e1n-Vega","year":"2022","journal-title":"Molecules"},{"issue":"3","key":"10.1016\/j.bbi.2026.107077_b0120","doi-asserted-by":"crossref","first-page":"218","DOI":"10.2174\/157015910792246209","article-title":"Clinical aspects of melatonin intervention in Alzheimer's disease progression","volume":"8","author":"Cardinali","year":"2010","journal-title":"Curr. Neuropharmacol."},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0090","doi-asserted-by":"crossref","first-page":"482","DOI":"10.1007\/s43440-023-00466-4","article-title":"GLUT inhibitor WZB117 induces cytotoxicity with increased production of amyloid-beta peptide in SH-SY5Y cells preventable by beta-hydroxybutyrate: implications in Alzheimer\u2019s disease: G. Chandan et al","volume":"75","author":"Chandan","year":"2023","journal-title":"Pharmacol. Rep."},{"key":"10.1016\/j.bbi.2026.107077_b0530","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.cbi.2018.02.023","article-title":"Melatonin attenuates scopolamine-induced cognitive impairment via protecting against demyelination through BDNF-TrkB signaling in the mouse dentate gyrus","volume":"285","author":"Chen","year":"2018","journal-title":"Chem. Biol. Interact."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0155","doi-asserted-by":"crossref","DOI":"10.1111\/jpi.12774","article-title":"Melatonin ameliorates cognitive deficits through improving mitophagy in a mouse model of Alzheimer\u2019s disease","volume":"71","author":"Chen","year":"2021","journal-title":"J. Pineal Res."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0550","first-page":"439","article-title":"Paeoniflorin regulates the hypothalamic-pituitary-adrenal axis negative feedback in a rat model of post-traumatic stress disorder","volume":"23","author":"Chen","year":"2020","journal-title":"Iran. J. Basic Med. Sci."},{"issue":"6406","key":"10.1016\/j.bbi.2026.107077_b0460","doi-asserted-by":"crossref","DOI":"10.1126\/science.aan8821","article-title":"Combined adult neurogenesis and BDNF mimic exercise effects on cognition in an Alzheimer's mouse model","volume":"361","author":"Choi","year":"2018","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0175","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1186\/s13020-021-00546-8","article-title":"Neurogenesis-dependent antidepressant-like activity of Hericium erinaceus in an animal model of depression","volume":"16","author":"Chong","year":"2021","journal-title":"Chin. Med."},{"key":"10.1016\/j.bbi.2026.107077_b0095","doi-asserted-by":"crossref","DOI":"10.3389\/fnint.2021.733007","article-title":"Disruption of Glucose Metabolism in Aged Octodon degus: a sporadic Model of Alzheimer's Disease","volume":"15","author":"Cisternas","year":"2021","journal-title":"Front. Integr. Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0225","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1038\/s41598-018-37312-0","article-title":"Dissociable cognitive impairments in two strains of transgenic Alzheimer\u2019s disease mice revealed by a battery of object-based tests","volume":"9","author":"Creighton","year":"2019","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bbi.2026.107077_b0040","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/nrn2822","article-title":"New neurons and new memories: how does adult hippocampal neurogenesis affect learning and memory?","volume":"11","author":"Deng","year":"2010","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbi.2026.107077_b0350","doi-asserted-by":"crossref","first-page":"35","DOI":"10.3389\/fnbeh.2017.00035","article-title":"The Role of Early Growth Response 1 (EGR1) in Brain Plasticity and Neuropsychiatric Disorders","volume":"11","author":"Duclot","year":"2017","journal-title":"Front. Behav. Neurosci."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0440","doi-asserted-by":"crossref","first-page":"e1101","DOI":"10.1038\/tp.2017.68","article-title":"Depletion of adult neurogenesis using the chemotherapy drug temozolomide in mice induces behavioural and biological changes relevant to depression","volume":"7","author":"Egeland","year":"2017","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0600","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1750-1326-8-2","article-title":"Neuron loss in the 5XFAD mouse model of Alzheimer\u2019s disease correlates with intraneuronal A\u03b242 accumulation and Caspase-3 activation","volume":"8","author":"Eimer","year":"2013","journal-title":"Mol. Neurodegener."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0130","doi-asserted-by":"crossref","DOI":"10.1155\/2022\/8099459","article-title":"Melatonin ameliorates the progression of Alzheimer\u2019s disease by inducing TFEB nuclear translocation, promoting mitophagy, and regulating NLRP3 inflammasome activity","volume":"2022","author":"Fan","year":"2022","journal-title":"Biomed Res. Int."},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0575","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1111\/j.1600-079X.2004.00144.x","article-title":"Melatonin alleviates behavioral deficits associated with apoptosis and cholinergic system dysfunction in the APP 695 transgenic mouse model of Alzheimer's disease","volume":"37","author":"Feng","year":"2004","journal-title":"J. Pineal Res."},{"issue":"5","key":"10.1016\/j.bbi.2026.107077_b0205","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1016\/j.physbeh.2011.05.023","article-title":"Anomalies in social behaviors and exploratory activities in an APPswe\/PS1 mouse model of Alzheimer's disease","volume":"104","author":"Filali","year":"2011","journal-title":"Physiol. Behav."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0505","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1111\/j.1365-2125.2007.02911.x","article-title":"Inflammatory status and kynurenine metabolism in rheumatoid arthritis treated with melatonin","volume":"64","author":"Forrest","year":"2007","journal-title":"Br. J. Clin. Pharmacol."},{"key":"10.1016\/j.bbi.2026.107077_b0220","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.bbr.2018.07.007","article-title":"Depressive-and anxiety-like phenotypes in young adult APPSwe\/PS1dE9 transgenic mice with insensitivity to chronic mild stress","volume":"353","author":"Gao","year":"2018","journal-title":"Behav. Brain Res."},{"issue":"5","key":"10.1016\/j.bbi.2026.107077_b0185","doi-asserted-by":"crossref","first-page":"e5464","DOI":"10.1371\/journal.pone.0005464","article-title":"Adult-generated hippocampal neurons allow the flexible use of spatially precise learning strategies","volume":"4","author":"Garthe","year":"2009","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0285","article-title":"Effects of melatonin supplementation on oxidative stress: a systematic review and meta-analysis of randomized controlled trials","volume":"41","author":"Ghorbaninejad","year":"2020","journal-title":"Horm. Mol. Biol. Clin. Invest."},{"issue":"7","key":"10.1016\/j.bbi.2026.107077_b0410","doi-asserted-by":"crossref","first-page":"762","DOI":"10.1002\/hipo.22267","article-title":"Onset of hippocampus-dependent memory impairments in 5XFAD transgenic mouse model of Alzheimer's disease","volume":"24","author":"Girard","year":"2014","journal-title":"Hippocampus"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0485","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/s41467-021-23111-1","article-title":"Transcriptional signature in microglia associated with A\u03b2 plaque phagocytosis","volume":"12","author":"Grubman","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0515","doi-asserted-by":"crossref","first-page":"42","DOI":"10.32607\/20758251-2015-7-2-42-47","article-title":"NeuN As a Neuronal Nuclear Antigen and Neuron Differentiation Marker","volume":"7","author":"Gusel'nikova","year":"2015","journal-title":"Acta Nat."},{"issue":"1\u20132","key":"10.1016\/j.bbi.2026.107077_b0500","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0165-5728(92)90171-G","article-title":"The pineal hormone melatonin exaggerates development of collagen-induced arthritis in mice","volume":"39","author":"Hansson","year":"1992","journal-title":"J. Neuroimmunol."},{"issue":"6","key":"10.1016\/j.bbi.2026.107077_b0290","doi-asserted-by":"crossref","DOI":"10.3390\/cells10061382","article-title":"TGF-beta\/Smad Signalling in Neurogenesis: Implications for Neuropsychiatric Diseases","volume":"10","author":"Hiew","year":"2021","journal-title":"Cells"},{"key":"10.1016\/j.bbi.2026.107077_b0395","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.brainres.2008.03.079","article-title":"Females exhibit more extensive amyloid, but not tau, pathology in an Alzheimer transgenic model","volume":"1216","author":"Hirata-Fukae","year":"2008","journal-title":"Brain Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0240","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1186\/s13024-017-0207-7","article-title":"Depletion of adult neurogenesis exacerbates cognitive deficits in Alzheimer\u2019s disease by compromising hippocampal inhibition","volume":"12","author":"Hollands","year":"2017","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbi.2026.107077_b0105","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101304","article-title":"Exploring the multifunctional role of melatonin in regulating autophagy and sleep to mitigate Alzheimer\u2019s disease neuropathology","volume":"67","author":"Hossain","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0375","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s40265-023-01851-2","article-title":"Lecanemab: first Approval","volume":"83","author":"Hoy","year":"2023","journal-title":"Drugs"},{"issue":"10","key":"10.1016\/j.bbi.2026.107077_b0265","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1008971","article-title":"Increased phagocytosis in the presence of enhanced M2-like macrophage responses correlates with increased primary and latent HSV-1 infection","volume":"16","author":"Jaggi","year":"2020","journal-title":"PLoS Pathog."},{"key":"10.1016\/j.bbi.2026.107077_b0585","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2022.106210","article-title":"An integrated multi-omics approach revealed the regulation of melatonin on age-dependent mitochondrial function impair and lipid dyshomeostasis in mice hippocampus","volume":"179","author":"Jiang","year":"2022","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0330","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1111\/jpi.12114","volume":"56","author":"Juan","year":"2014","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbi.2026.107077_b0125","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.yfrne.2017.02.004","article-title":"Sleep and hippocampal neurogenesis: implications for Alzheimer\u2019s disease","volume":"45","author":"Kent","year":"2017","journal-title":"Front. Neuroendocrinol."},{"issue":"7","key":"10.1016\/j.bbi.2026.107077_b0070","doi-asserted-by":"crossref","DOI":"10.1016\/j.cell.2017.05.018","article-title":"A unique microglia type associated with restricting development of Alzheimer\u2019s disease","volume":"169","author":"Keren-Shaul","year":"2017","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0145","doi-asserted-by":"crossref","first-page":"142","DOI":"10.1111\/j.1600-079X.2008.00568.x","article-title":"Delayed melatonin administration promotes neuronal survival, neurogenesis and motor recovery, and attenuates hyperactivity and anxiety after mild focal cerebral ischemia in mice","volume":"45","author":"Kilic","year":"2008","journal-title":"J. Pineal Res."},{"issue":"11","key":"10.1016\/j.bbi.2026.107077_b0430","first-page":"1","article-title":"Deep proteome profiling of the hippocampus in the 5XFAD mouse model reveals biological process alterations and a novel biomarker of Alzheimer's disease","volume":"51","author":"Kim","year":"2019","journal-title":"Exp. Mol. Med."},{"issue":"3","key":"10.1016\/j.bbi.2026.107077_b0135","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1111\/j.1600-079X.2004.00157.x","article-title":"Melatonin increases cell proliferation in the dentate gyrus of maternally separated rats","volume":"37","author":"Kim","year":"2004","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0270","doi-asserted-by":"crossref","first-page":"11118","DOI":"10.1038\/s41598-017-11634-x","article-title":"TREM2 promotes A\u03b2 phagocytosis by upregulating C\/EBP\u03b1-dependent CD36 expression in microglia","volume":"7","author":"Kim","year":"2017","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0520","doi-asserted-by":"crossref","first-page":"569","DOI":"10.1007\/s10571-007-9212-7","article-title":"Melatonin regulates the viability and differentiation of rat midbrain neural stem cells","volume":"28","author":"Kong","year":"2008","journal-title":"Cell. Mol. Neurobiol."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0470","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060921","article-title":"Functional impairment of microglia coincides with Beta-amyloid deposition in mice with Alzheimer-like pathology","volume":"8","author":"Krabbe","year":"2013","journal-title":"PLoS One"},{"issue":"3","key":"10.1016\/j.bbi.2026.107077_b0475","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1038\/s41582-020-00435-y","article-title":"Neuroinflammation and microglial activation in Alzheimer disease: where do we go from here?","volume":"17","author":"Leng","year":"2021","journal-title":"Nat. Rev. Neurol."},{"issue":"7","key":"10.1016\/j.bbi.2026.107077_b0025","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1111\/cns.14143","article-title":"MicroRNA-128 suppresses tau phosphorylation and reduces amyloid-beta accumulation by inhibiting the expression of GSK3beta, APPBP2, and mTOR in Alzheimer's disease","volume":"29","author":"Li","year":"2023","journal-title":"CNS Neurosci. Ther."},{"key":"10.1016\/j.bbi.2026.107077_b0045","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.04803","article-title":"Ventromedial prefrontal cortex stimulation enhances memory and hippocampal neurogenesis in the middle-aged rats","volume":"4","author":"Liu","year":"2015","journal-title":"Elife"},{"issue":"19","key":"10.1016\/j.bbi.2026.107077_b0260","doi-asserted-by":"crossref","first-page":"3224","DOI":"10.1093\/hmg\/ddaa209","article-title":"Trem2 promotes anti-inflammatory responses in microglia and is suppressed under pro-inflammatory conditions","volume":"29","author":"Liu","year":"2020","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbi.2026.107077_b0365","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2025.102755","article-title":"Past, present, and future of serotonin-targeting therapeutics for Alzheimer's disease: Perspectives from DNA methylation","volume":"108","author":"Liu","year":"2025","journal-title":"Ageing Res. Rev."},{"issue":"5","key":"10.1016\/j.bbi.2026.107077_b0030","first-page":"2710","article-title":"Homeostatic DNMT3a activity is Required to Restore Cognition and Hippocampal DNA Methylation in the 5xFAD Model of Alzheimer's Disease","volume":"17","author":"Liu","year":"2025","journal-title":"Aging Dis."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0115","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1186\/s13195-026-01990-0","article-title":"Upregulation of SLC38A2 by melatonin attenuates hippocampal ferroptosis in Alzheimer\u2019s disease","volume":"18","author":"Lv","year":"2026","journal-title":"Alzheimers Res. Ther."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0230","doi-asserted-by":"crossref","first-page":"1259","DOI":"10.3233\/JAD-180678","article-title":"5xFAD mice display sex-dependent inflammatory gene induction during the prodromal stage of Alzheimer\u2019s disease","volume":"70","author":"Manji","year":"2019","journal-title":"Journal of Alzheimer\u2019s Disease."},{"issue":"5","key":"10.1016\/j.bbi.2026.107077_b0455","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1046\/j.1471-4159.2003.01654.x","article-title":"Melatonin increases survival and inhibits oxidative and amyloid pathology in a transgenic model of Alzheimer's disease","volume":"85","author":"Matsubara","year":"2003","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbi.2026.107077_b0195","series-title":"Designing experiments and analyzing data","author":"Maxwell","year":"2017"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0100","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/nyas.14436","article-title":"Therapeutic potential of neurogenesis and melatonin regulation in Alzheimer's disease","volume":"1478","author":"Mihardja","year":"2020","journal-title":"Ann. N. Y. Acad. Sci."},{"key":"10.1016\/j.bbi.2026.107077_b0445","article-title":"Knockdown of BACE1-AS Nonprotein-Coding Transcript Modulates Beta-Amyloid-Related Hippocampal Neurogenesis","volume":"2011","author":"Modarresi","year":"2011","journal-title":"Int. J. Alzheimers Dis."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0315","doi-asserted-by":"crossref","first-page":"17005","DOI":"10.1038\/s41598-018-35429-w","article-title":"IL-1\u03b2- and IL-4-polarized macrophages have opposite effects on adipogenesis of intramuscular fibro-adipogenic progenitors in humans","volume":"8","author":"Moratal","year":"2018","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0050","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1038\/s41591-019-0375-9","article-title":"Adult hippocampal neurogenesis is abundant in neurologically healthy subjects and drops sharply in patients with Alzheimer\u2019s disease","volume":"25","author":"Moreno-Jim\u00e9nez","year":"2019","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0140","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1111\/j.1600-079X.2007.00435.x","article-title":"Melatonin influences the proliferative and differentiative activity of neural stem cells","volume":"42","author":"Moriya","year":"2007","journal-title":"J. Pineal Res."},{"key":"10.1016\/j.bbi.2026.107077_b0060","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1196\/annals.1427.007","article-title":"Brain glucose hypometabolism and oxidative stress in preclinical Alzheimer's disease","volume":"1147","author":"Mosconi","year":"2008","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"7863","key":"10.1016\/j.bbi.2026.107077_b0370","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/d41586-021-01546-2","article-title":"Landmark Alzheimer's drug approval confounds research community","volume":"594","author":"Mullard","year":"2021","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0180","doi-asserted-by":"crossref","first-page":"593","DOI":"10.1002\/biof.1369","article-title":"Melatonin ameliorates anxiety and depression-like behaviors and modulates proteomic changes in triple transgenic mice of Alzheimer's disease","volume":"43","author":"Nie","year":"2017","journal-title":"Biofactors"},{"issue":"6","key":"10.1016\/j.bbi.2026.107077_b0085","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1016\/j.neuron.2008.10.047","article-title":"Phosphorylation of the translation initiation factor eIF2\u03b1 increases BACE1 levels and promotes amyloidogenesis","volume":"60","author":"O'Connor","year":"2008","journal-title":"Neuron"},{"key":"10.1016\/j.bbi.2026.107077_b0425","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1186\/s13024-015-0027-6","article-title":"Prophylactic melatonin significantly reduces Alzheimer's neuropathology and associated cognitive deficits independent of antioxidant pathways in A\u03b2PP(swe)\/PS1 mice","volume":"10","author":"O'Neal-Moffitt","year":"2015","journal-title":"Mol. Neurodegener."},{"issue":"40","key":"10.1016\/j.bbi.2026.107077_b0595","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal \u03b2-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer's disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbi.2026.107077_b0235","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.713726","article-title":"Comprehensive Evaluation of the 5XFAD Mouse Model for Preclinical Testing applications: a MODEL-AD Study","volume":"13","author":"Oblak","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0325","doi-asserted-by":"crossref","first-page":"276","DOI":"10.2174\/157015909790031210","article-title":"A new aspect of the TrkB signaling pathway in neural plasticity","volume":"7","author":"Ohira","year":"2009","journal-title":"Curr. Neuropharmacol."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0450","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1016\/j.stemcr.2016.08.019","article-title":"Amyloid \u03b2 is not the Major factor Accounting for Impaired Adult Hippocampal Neurogenesis in mice Overexpressing Amyloid Precursor Protein","volume":"7","author":"Pan","year":"2016","journal-title":"Stem Cell Rep."},{"issue":"3","key":"10.1016\/j.bbi.2026.107077_b0295","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1006\/nbdi.2001.0395","article-title":"Corticotropin-releasing hormone protects neurons against insults relevant to the pathogenesis of Alzheimer's disease","volume":"8","author":"Pedersen","year":"2001","journal-title":"Neurobiol. Dis."},{"issue":"32","key":"10.1016\/j.bbi.2026.107077_b0610","doi-asserted-by":"crossref","first-page":"3927","DOI":"10.1016\/j.jchromb.2011.09.020","article-title":"Surrogate based accurate quantification of endogenous acetylcholine in murine brain by hydrophilic interaction liquid chromatography-tandem mass spectrometry","volume":"879","author":"Peng","year":"2011","journal-title":"J. Chromatogr. B Anal. Technol. Biomed. Life Sci."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0190","doi-asserted-by":"crossref","first-page":"112","DOI":"10.14336\/AD.2022.0706","article-title":"Prelimbic cortical stimulation with L-methionine enhances cognition through hippocampal DNA methylation and neuroplasticity mechanisms","volume":"14","author":"Poon","year":"2023","journal-title":"Aging Dis."},{"issue":"5","key":"10.1016\/j.bbi.2026.107077_b0015","doi-asserted-by":"crossref","first-page":"1235","DOI":"10.14336\/AD.2019.1026","article-title":"Rodent models of amyloid-beta feature of Alzheimer\u2019s disease: Development and potential treatment implications","volume":"11","author":"Poon","year":"2020","journal-title":"Aging Dis."},{"issue":"5","key":"10.1016\/j.bbi.2026.107077_b0020","doi-asserted-by":"crossref","first-page":"780","DOI":"10.3390\/cells12050780","article-title":"Sex differences between neuronal loss and the early onset of amyloid deposits and behavioral consequences in 5xFAD transgenic mouse as a model for Alzheimer\u2019s disease","volume":"12","author":"Poon","year":"2023","journal-title":"Cells"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0210","doi-asserted-by":"crossref","first-page":"102","DOI":"10.1186\/s13195-019-0554-4","article-title":"EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer\u2019s disease","volume":"11","author":"Poppe","year":"2019","journal-title":"Alzheimers Res. Ther."},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0590","doi-asserted-by":"crossref","DOI":"10.1016\/j.isci.2021.102126","article-title":"L-lactate exerts a pro-proliferative effect on adult hippocampal precursor cells invitro","volume":"24","author":"P\u00f6tzsch","year":"2021","journal-title":"iScience"},{"issue":"9","key":"10.1016\/j.bbi.2026.107077_b0525","doi-asserted-by":"crossref","first-page":"2180","DOI":"10.1038\/npp.2009.46","article-title":"Melatonin modulates cell survival of new neurons in the hippocampus of adult mice","volume":"34","author":"Ram\u00edrez-Rodr\u00edguez","year":"2009","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0385","article-title":"Donanemab for Alzheimer's Disease: a Systematic Review of Clinical Trials","volume":"11","author":"Rashad","year":"2022","journal-title":"Healthcare (Basel)"},{"key":"10.1016\/j.bbi.2026.107077_b0250","doi-asserted-by":"crossref","first-page":"160","DOI":"10.3389\/fnagi.2016.00160","article-title":"Mechanisms of A\u03b2 clearance and degradation by glial cells","volume":"8","author":"Ries","year":"2016","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.bbi.2026.107077_b0280","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1007\/s00213-008-1344-z","article-title":"Melatonin improves memory acquisition under stress independent of stress hormone release","volume":"202","author":"Rimmele","year":"2009","journal-title":"Psychopharmacology"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0480","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1186\/s12974-019-1645-7","article-title":"IL-1\u03b2-driven amyloid plaque clearance is associated with an expansion of transcriptionally reprogrammed microglia","volume":"16","author":"Rivera-Escalera","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0035","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/j.1469-7580.2011.01343.x","article-title":"Neurogenesis in Alzheimer\u2019s disease","volume":"219","author":"Rodr\u00edguez","year":"2011","journal-title":"J. Anat."},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0605","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1111\/j.1600-079X.2011.00937.x","article-title":"Alzheimer\u2019s disease: pathological mechanisms and the beneficial role of melatonin","volume":"52","author":"Rosales-Corral","year":"2012","journal-title":"J. Pineal Res."},{"issue":"13","key":"10.1016\/j.bbi.2026.107077_b0355","doi-asserted-by":"crossref","DOI":"10.3390\/ijms22136841","article-title":"Regulation of Melatonin and Neurotransmission in Alzheimer's Disease","volume":"22","author":"Roy","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.107077_b0110","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2022.100986","article-title":"Role of melatonin in Alzheimer\u2019s disease: from preclinical studies to novel melatonin-based therapies","volume":"65","author":"Roy","year":"2022","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bbi.2026.107077_b0405","doi-asserted-by":"crossref","first-page":"335","DOI":"10.3389\/fnagi.2019.00335","article-title":"Early Cognitive and Behavioral Deficits in Mouse Models for Tauopathy and Alzheimer's Disease","volume":"11","author":"Samaey","year":"2019","journal-title":"Front. Aging Neurosci."},{"issue":"6","key":"10.1016\/j.bbi.2026.107077_b0320","doi-asserted-by":"crossref","first-page":"1514","DOI":"10.1038\/mi.2016.23","article-title":"CD45 regulates GM-CSF, retinoic acid and T-cell homing in intestinal inflammation","volume":"9","author":"Samarakoon","year":"2016","journal-title":"Mucosal Immunol."},{"issue":"8","key":"10.1016\/j.bbi.2026.107077_b0490","doi-asserted-by":"crossref","first-page":"5135","DOI":"10.1007\/s12035-022-02873-9","article-title":"Cyanidin-3-O-Glucoside Regulates the M1\/M2 Polarization of Microglia via PPAR\u03b3 and A\u03b242 Phagocytosis through TREM2 in an Alzheimer's Disease Model","volume":"59","author":"Sanjay","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbi.2026.107077_b0540","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchemneu.2023.102269","article-title":"Agomelatine attenuates cisplatin-induced cognitive impairment via modulation of BDNF\/TrkB signaling in rat hippocampus","volume":"130","author":"Saral","year":"2023","journal-title":"J. Chem. Neuroanat."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0560","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1034\/j.1600-079x.2002.00841.x","article-title":"Increased melatonin 1a-receptor immunoreactivity in the hippocampus of Alzheimer's disease patients","volume":"32","author":"Savaskan","year":"2002","journal-title":"J. Pineal Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0160","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/s12993-025-00271-4","article-title":"Improving effects of melatonin on memory and synaptic potentiation in a mouse model of Alzheimer\u2019s-like disease: the involvement of glutamate homeostasis and mGluRs receptors","volume":"21","author":"Shabani Sadr","year":"2025","journal-title":"Behav. Brain Funct."},{"key":"10.1016\/j.bbi.2026.107077_b0415","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s13041-016-0191-9","article-title":"Age-related changes in behavior in C57BL\/6J mice from young adulthood to middle age","volume":"9","author":"Shoji","year":"2016","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbi.2026.107077_b0010","article-title":"Alzheimer\u2019s disease: risk factors and potentially protective measures","volume":"26(1):33","author":"Silva","year":"2019","journal-title":"J. Biomed. Sci."},{"issue":"6","key":"10.1016\/j.bbi.2026.107077_b0380","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1001\/jama.2023.13239","article-title":"Donanemab in Early Symptomatic Alzheimer Disease: the TRAILBLAZER-ALZ 2 Randomized Clinical Trial","volume":"330","author":"Sims","year":"2023","journal-title":"J. Am. Med. Assoc."},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0345","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1080\/08039488.2018.1563213","article-title":"Correlation of metabolic parameters, neurotrophin-3, and neurotrophin-4 serum levels in women with schizophrenia and first-onset depression","volume":"73","author":"Skibinska","year":"2019","journal-title":"Nord. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0465","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-020-01099-x","article-title":"Microglial gene signature reveals loss of homeostatic microglia associated with neurodegeneration of Alzheimer's disease","volume":"9","author":"Sobue","year":"2021","journal-title":"Acta Neuropathol. Commun."},{"issue":"5","key":"10.1016\/j.bbi.2026.107077_b0340","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1053\/j.gastro.2020.07.018","article-title":"Glial Cell-Derived Neurotrophic factor Induces Enteric Neurogenesis and Improves Colon Structure and Function in Mouse Models of Hirschsprung Disease","volume":"159","author":"Soret","year":"2020","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0245","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1007\/s12035-020-02120-z","article-title":"Chronic memantine treatment ameliorates behavioral deficits, neuron loss, and impaired neurogenesis in a model of Alzheimer\u2019s disease","volume":"58","author":"Stazi","year":"2021","journal-title":"Mol. Neurobiol."},{"issue":"10","key":"10.1016\/j.bbi.2026.107077_b0300","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1038\/nrn3564","article-title":"p11 and its role in depression and therapeutic responses to antidepressants","volume":"14","author":"Svenningsson","year":"2013","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0615","doi-asserted-by":"crossref","first-page":"36","DOI":"10.14336\/AD.2020.0602","article-title":"Interdisciplinary Research in Alzheimer's Disease and the Roles International Societies can Play","volume":"12","author":"Tan","year":"2021","journal-title":"Aging Dis."},{"issue":"13","key":"10.1016\/j.bbi.2026.107077_b0580","doi-asserted-by":"crossref","first-page":"3002","DOI":"10.1002\/jnr.22123","article-title":"Melatonin and its brain metabolite N(1)-acetyl-5-methoxykynuramine prevent mitochondrial nitric oxide synthase induction in parkinsonian mice","volume":"87","author":"Tapias","year":"2009","journal-title":"J. Neurosci. Res."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0080","doi-asserted-by":"crossref","first-page":"9576","DOI":"10.1038\/s41598-018-27839-7","article-title":"Chemical exchange saturation transfer MRI shows low cerebral 2-deoxy-D-glucose uptake in a model of Alzheimer\u2019s Disease","volume":"8","author":"Tolomeo","year":"2018","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0310","doi-asserted-by":"crossref","DOI":"10.1128\/JVI.01511-19","article-title":"CD80 Plays a critical Role in increased Inflammatory responses in Herpes Simplex Virus 1-Infected Mouse Corneas","volume":"94","author":"Tormanen","year":"2020","journal-title":"J. Virol."},{"issue":"8","key":"10.1016\/j.bbi.2026.107077_b0055","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1016\/j.neubiorev.2013.05.008","article-title":"Ascending monoaminergic systems alterations in Alzheimer's disease. translating basic science into clinical care","volume":"37","author":"Trillo","year":"2013","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbi.2026.107077_b0165","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2022.964336","article-title":"Distribution and inter-regional relationship of amyloid-beta plaque deposition in a 5xFAD mouse model of Alzheimer\u2019s disease","volume":"14","author":"Tsui","year":"2022","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbi.2026.107077_b0255","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2022.101622","article-title":"Glial cells in Alzheimer's disease: from neuropathological changes to therapeutic implications","volume":"78","author":"Uddin","year":"2022","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbi.2026.107077_b0275","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2021.101417","article-title":"Exploring ER stress response in cellular aging and neuroinflammation in Alzheimer's disease","volume":"70","author":"Uddin","year":"2021","journal-title":"Ageing Res. Rev."},{"issue":"11","key":"10.1016\/j.bbi.2026.107077_b0075","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/s41582-018-0072-1","article-title":"TREM2\u2014a key player in microglial biology and Alzheimer disease","volume":"14","author":"Ulland","year":"2018","journal-title":"Nat. Rev. Neurol."},{"issue":"12","key":"10.1016\/j.bbi.2026.107077_b0570","doi-asserted-by":"crossref","first-page":"2691","DOI":"10.1016\/j.neurobiolaging.2014.05.031","article-title":"Monoaminergic neurotransmitter alterations in postmortem brain regions of depressed and aggressive patients with Alzheimer's disease","volume":"35","author":"Vermeiren","year":"2014","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0390","article-title":"Translational animal models for Alzheimer's disease: an Alzheimer's Association Business Consortium think Tank","volume":"6","author":"Vitek","year":"2020","journal-title":"Alzheimers Dement (n y)."},{"issue":"15","key":"10.1016\/j.bbi.2026.107077_b0510","doi-asserted-by":"crossref","first-page":"2372","DOI":"10.1007\/s00018-008-8053-y","article-title":"Behavior of neural stem cells in the Alzheimer brain","volume":"65","author":"Waldau","year":"2008","journal-title":"Cell. Mol. Life Sci."},{"issue":"6","key":"10.1016\/j.bbi.2026.107077_b0555","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1016\/j.biopsych.2010.04.029","article-title":"A role for p11 in the antidepressant action of brain-derived neurotrophic factor","volume":"68","author":"Warner-Schmidt","year":"2010","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbi.2026.107077_b0400","doi-asserted-by":"crossref","first-page":"88","DOI":"10.3389\/fgene.2014.00088","article-title":"Using mice to model Alzheimer's dementia: an overview of the clinical disease and the preclinical behavioral changes in 10 mouse models","volume":"5","author":"Webster","year":"2014","journal-title":"Front. Genet."},{"issue":"5","key":"10.1016\/j.bbi.2026.107077_b0360","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.14336\/AD.2019.1125","article-title":"Relationships between Mitochondrial Dysfunction and Neurotransmission failure in Alzheimer's Disease","volume":"11","author":"Wong","year":"2020","journal-title":"Aging Dis."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0545","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1186\/s12974-022-02617-5","article-title":"Promoted CD4(+) T cell-derived IFN-\u03b3\/IL-10 by photobiomodulation therapy modulates neurogenesis to ameliorate cognitive deficits in APP\/PS1 and 3xTg-AD mice","volume":"19","author":"Wu","year":"2022","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.bbi.2026.107077_b0495","doi-asserted-by":"crossref","DOI":"10.3390\/cells10020321","article-title":"TREM2 Mediates Microglial Anti-Inflammatory Activations in Alzheimer's Disease: Lessons Learned from Transcriptomics","volume":"10","author":"Xue","year":"2021","journal-title":"Cells"},{"issue":"3","key":"10.1016\/j.bbi.2026.107077_b0170","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.brs.2022.05.018","article-title":"Antidepressant-like effects of transcorneal electrical stimulation in rat models","volume":"15","author":"Yu","year":"2022","journal-title":"Brain Stimul."},{"issue":"1","key":"10.1016\/j.bbi.2026.107077_b0535","doi-asserted-by":"crossref","DOI":"10.3390\/ijms26010338","article-title":"Data Mining Approach to Melatonin Treatment in Alzheimer's Disease: New Gene Targets MMP2 and NR3C1","volume":"26","author":"Zhang","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbi.2026.107077_b0335","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110809","article-title":"Melatonin attenuates sevoflurane-induced hippocampal damage and cognitive deficits in neonatal mice by suppressing CypD in parvalbumin neurons","volume":"204","author":"Zou","year":"2023","journal-title":"Brain Res. Bull."}],"container-title":["Brain, Behavior, and Immunity"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126008251?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S0889159126008251?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,10,31]],"date-time":"2026-10-31T11:46:53Z","timestamp":1793447213000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S0889159126008251"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2027,2]]},"references-count":123,"alternative-id":["S0889159126008251"],"URL":"https:\/\/doi.org\/10.1016\/j.bbi.2026.107077","relation":{},"ISSN":["0889-1591"],"issn-type":[{"value":"0889-1591","type":"print"}],"subject":[],"published":{"date-parts":[[2027,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Melatonin ameliorates behavioral deficits in 5xFAD mice through modulation of neurogenesis, neuroimmune responses, neurotransmission, and metabolic pathways","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, and Immunity","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbi.2026.107077","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.","name":"copyright","label":"Copyright"}],"article-number":"107077"}}