{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,7]],"date-time":"2026-09-07T03:54:10Z","timestamp":1788753250294,"version":"build-2803163510"},"reference-count":166,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,1,1]],"date-time":"2020-01-01T00:00:00Z","timestamp":1577836800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2019,9,30]],"date-time":"2019-09-30T00:00:00Z","timestamp":1569801600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100007726","name":"ASD","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007726","id-type":"DOI","asserted-by":"publisher"}]},{"name":"FDA"},{"DOI":"10.13039\/100011408","name":"USA","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100011408","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2020,1]]},"DOI":"10.1016\/j.bbih.2019.100003","type":"journal-article","created":{"date-parts":[[2019,11,18]],"date-time":"2019-11-18T01:34:50Z","timestamp":1574040890000},"page":"100003","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["The aetiology of social deficits within mental health disorders: The role of the immune system and endogenous opioids"],"prefix":"10.1016","volume":"1","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3559-1141","authenticated-orcid":false,"given":"Sarah J.","family":"Charles","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5925-795X","authenticated-orcid":false,"given":"Miguel","family":"Farias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9982-9702","authenticated-orcid":false,"given":"Robin I.M.","family":"Dunbar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"10","key":"10.1016\/j.bbih.2019.100003_bib2","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1016\/0006-3223(93)90041-B","article-title":"Pain perception threshold in major depression","volume":"34","author":"Adler","year":"1993","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbih.2019.100003_bib3","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.neubiorev.2017.08.019","article-title":"Treatment resistant depression: a multi-scale, systems biology approach","volume":"84","author":"Akil","year":"2018","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbih.2019.100003_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2019.07.005","article-title":"Heterogeneity in psychiatric diagnostic classification","author":"Allsopp","year":"2019","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbih.2019.100003_bib5","doi-asserted-by":"crossref","first-page":"2869","DOI":"10.1111\/bph.14060","article-title":"Antidepressant-like effects of BU10119, a novel buprenorphine analogue with mixed kappa\/mu receptor antagonist properties, in mice","volume":"175","author":"Almatroudi","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2019.100003_bib6","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1159\/000335095","article-title":"Inflammation mobilizes local resources to control hyperalgesia: the role of endogenous opioid peptides","volume":"89","author":"Alves","year":"2012","journal-title":"Pharmacology"},{"key":"10.1016\/j.bbih.2019.100003_bib7","first-page":"299.00","article-title":"Diagnostic and statistical manual of mental disorders (DSM-5\u00ae)","author":"American Psychiatric Association","year":"2013","journal-title":"Am. Psychiatr. Pub"},{"key":"10.1016\/j.bbih.2019.100003_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/S0924-977X(17)31615-2","article-title":"Mu-opioid receptor availability in schizophrenia patients: a PET study using [11C]-carfentanil","volume":"27","author":"Ashok","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"7\u20138","key":"10.1016\/j.bbih.2019.100003_bib9","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1016\/j.autrev.2004.07.036","article-title":"Is autism an autoimmune disease?","volume":"3","author":"Ashwood","year":"2004","journal-title":"Autoimmun. Rev."},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib10","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1080\/10446670410001722096","article-title":"A\u00a0review of autism and the immune response","volume":"11","author":"Ashwood","year":"2004","journal-title":"J.\u00a0Immunol. Res."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib11","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s00296-017-3866-3","article-title":"Association between cortisol levels and pain threshold in systemic sclerosis and major depression","volume":"38","author":"Bagnato","year":"2018","journal-title":"Rheumatol. Int."},{"issue":"5","key":"10.1016\/j.bbih.2019.100003_bib165","doi-asserted-by":"crossref","first-page":"e258","DOI":"10.1038\/tp.2013.34","article-title":"Sniffing around oxytocin: Review and meta-analyses of trials in healthy and clinical groups with implications for pharmacotherapy","volume":"3","author":"Bakermans-Kranenburg","year":"2013","journal-title":"Translational Psychiatry"},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib164","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1097\/YPG.0b013e3283643684","article-title":"A\u00a0sociability gene? Meta-analysis of oxytocin receptor genotype effects in humans","volume":"24","author":"Bakermans-Kranenburg","year":"2014","journal-title":"Psychiatric genetics"},{"issue":"1\u20132","key":"10.1016\/j.bbih.2019.100003_bib12","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.pain.2005.05.016","article-title":"Pain perception in major depression depends on pain modality","volume":"117","author":"B\u00e4r","year":"2005","journal-title":"Pain"},{"issue":"13","key":"10.1016\/j.bbih.2019.100003_bib13","doi-asserted-by":"crossref","first-page":"5277","DOI":"10.1073\/pnas.0710225105","article-title":"Variation at the mu-opioid receptor gene (OPRM1) influences attachment behavior in infant primates","volume":"105","author":"Barr","year":"2008","journal-title":"Proc. Natl. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1172\/JCI34431","article-title":"A\u00a0calculated response: control of inflammation by the innate immune system","volume":"118","author":"Barton","year":"2008","journal-title":"J.\u00a0Clin. Investig."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/0304-3940(89)90393-5","article-title":"Cells of the rat lateral habenula respond to high-threshold somatosensory inputs","volume":"96","author":"Benabid","year":"1989","journal-title":"Neurosci. Lett."},{"issue":"8","key":"10.1016\/j.bbih.2019.100003_bib158","doi-asserted-by":"crossref","first-page":"807","DOI":"10.1212\/WNL.0b013e3182662098","article-title":"Endogenous opioid systems Current concepts and clinical correlations","volume":"79","author":"Benarroch","year":"2012","journal-title":"Neurology"},{"key":"10.1016\/j.bbih.2019.100003_bib166","doi-asserted-by":"crossref","first-page":"8026","DOI":"10.1073\/pnas.1120666109","article-title":"The genetic architecture of economic and political preferences","volume":"109","author":"Benjamin","year":"2012","journal-title":"Proceedings of the National Academy of Sciences, USA"},{"issue":"1519","key":"10.1016\/j.bbih.2019.100003_bib16","doi-asserted-by":"crossref","first-page":"1005","DOI":"10.1098\/rstb.2008.0213","article-title":"The habenular nuclei: a conserved asymmetric relay station in the vertebrate brain","volume":"364","author":"Bianco","year":"2009","journal-title":"Philos. Trans. R. Soc. Biol. Sci."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib17","doi-asserted-by":"crossref","first-page":"257","DOI":"10.21307\/ane-2017-025","article-title":"Immune dysfunction and neuroinflammation in autism spectrum disorder","volume":"76","author":"Bj\u00f8rklund","year":"2016","journal-title":"Acta Neurobiol. Exp."},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib18","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1093\/schbul\/sbj013","article-title":"The structure of negative symptoms within schizophrenia: implications for assessment","volume":"32","author":"Blanchard","year":"2006","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbih.2019.100003_bib19","doi-asserted-by":"crossref","DOI":"10.4049\/jimmunol.0802763","article-title":"Mechanisms of opioid-mediated inhibition of human T cell receptor signaling","author":"B\u00f6rner","year":"2009","journal-title":"J.\u00a0Immunol."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2019.100003_bib20","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jneuroim.2013.07.012","article-title":"Mu opioid receptor agonist-selective regulation of interleukin-4 in T lymphocytes","volume":"263","author":"B\u00f6rner","year":"2013","journal-title":"J.\u00a0Neuroimmunol."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/0165-1781(95)02601-R","article-title":"Low-dose naltrexone effects on plasma chemistries and clinical symptoms in autism: a double-blind, placebo-controlled study","volume":"58","author":"Bouvard","year":"1995","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbih.2019.100003_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2019.04.009","article-title":"Targeting opioid dysregulation in depression for the development of novel therapeutics","author":"Browne","year":"2019","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbih.2019.100003_bib23","doi-asserted-by":"crossref","first-page":"46","DOI":"10.3389\/fnsyn.2018.00046","article-title":"Dysregulation of the lateral habenula in major depressive disorder","volume":"10","author":"Browne","year":"2018","journal-title":"Front. Synaptic Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s00213-012-2794-x","article-title":"The behavioral, anatomical and pharmacological parallels between social attachment, love and addiction","volume":"224","author":"Burkett","year":"2012","journal-title":"Psychopharmacology"},{"issue":"11","key":"10.1016\/j.bbih.2019.100003_bib25","doi-asserted-by":"crossref","first-page":"2200","DOI":"10.1038\/npp.2011.117","article-title":"Activation of \u03bc-opioid receptors in the dorsal striatum is necessary for adult social attachment in monogamous prairie voles","volume":"36","author":"Burkett","year":"2011","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbih.2019.100003_bib26","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cobeha.2016.12.003","article-title":"Neuroinflammation\u2014a co-occurring phenomenon linking chronic pain and opioid dependence","volume":"13","author":"Cahill","year":"2017","journal-title":"Curr Opin. Behav. Sci."},{"issue":"6","key":"10.1016\/j.bbih.2019.100003_bib27","doi-asserted-by":"crossref","first-page":"1283","DOI":"10.1097\/00004583-199311000-00024","article-title":"Naltrexone in autistic children: behavioral symptoms and attentional learning","volume":"32","author":"Campbell","year":"1993","journal-title":"J.\u00a0Am. Acad. Child Adolesc. Psychiatry"},{"issue":"1-3","key":"10.1016\/j.bbih.2019.100003_bib161","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/j.schres.2008.03.004","article-title":"Coagulation and inflammation markers during atypical or typical antipsychotic treatment in schizophrenia patients and drug-free first-degree relatives","volume":"103","author":"Carrizo","year":"2008","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib28","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1038\/sj.npp.1300856","article-title":"The mu-opioid receptor polymorphism A118G predicts cortisol responses to naloxone and stress","volume":"31","author":"Chong","year":"2006","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib29","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1098\/rsbl.2009.0670","article-title":"Rowers\u2019 high: behavioural synchrony is correlated with elevated pain thresholds","volume":"6","author":"Cohen","year":"2010","journal-title":"Biol. Lett."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib30","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1093\/oxfordjournals.schbul.a007038","article-title":"The stress cascade and schizophrenia: etiology and onset","volume":"29","author":"Corcoran","year":"2003","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbih.2019.100003_bib31","series-title":"Immunopharmacology and Inflammation","first-page":"107","article-title":"Neural regulation of inflammation: pharmacological mechanisms and therapeutic perspectives","author":"Cosentino","year":"2018"},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib32","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbih.2019.100003_bib33","first-page":"21","article-title":"The social brain hypothesis and its relevance to social psychology","author":"Dunbar","year":"2007","journal-title":"Evol. Soc. Mind: Evol. Psychol. Soc. Cognit."},{"issue":"5","key":"10.1016\/j.bbih.2019.100003_bib34","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1080\/03014460902960289","article-title":"The social brain hypothesis and its implications for social evolution","volume":"36","author":"Dunbar","year":"2009","journal-title":"Ann. Hum. Biol."},{"issue":"6","key":"10.1016\/j.bbih.2019.100003_bib35","doi-asserted-by":"crossref","first-page":"1086","DOI":"10.1345\/aph.1G499","article-title":"Pediatrics efficacy and safety of naltrexone use in pediatric patients with autistic disorder","volume":"40","author":"Eichaar","year":"2006","journal-title":"Ann. Pharmacother."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib36","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1007\/s40489-015-0051-z","article-title":"Exploring the potential role of inflammation as an etiological process in ASD","volume":"2","author":"Elias","year":"2015","journal-title":"Rev. J. Autism Dev. Disord."},{"issue":"5","key":"10.1016\/j.bbih.2019.100003_bib37","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1080\/14737175.2017.1307737","article-title":"Moving forward: how depression heterogeneity hinders progress in treatment and research","volume":"17","author":"Fried","year":"2017","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bbih.2019.100003_bib38","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.jad.2014.10.010","article-title":"Depression is not a consistent syndrome: an investigation of unique symptom patterns in the STAR* D study","volume":"172","author":"Fried","year":"2015","journal-title":"J.\u00a0Affect. Disord."},{"issue":"12","key":"10.1016\/j.bbih.2019.100003_bib39","doi-asserted-by":"crossref","DOI":"10.1002\/gps.4645","article-title":"Depression with inflammation: longitudinal analysis of a proposed depressive subtype in community dwelling older adults","volume":"32","author":"Gallagher","year":"2017","journal-title":"Int. J. Geriatr. Psychiatr."},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib40","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.psychres.2011.08.014","article-title":"Inflammatory markers in antipsychotic-na\u00efve patients with nonaffective psychosis and deficit vs. nondeficit features","volume":"198","author":"Garcia-Rizo","year":"2012","journal-title":"Psychiatr. Res."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib41","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1037\/a0032332","article-title":"Endogenous opioids mediate the sexual inhibition but not the drug hypersensitivity induced by sexual satiation in male rats","volume":"127","author":"Gardu\u00f1o-Guti\u00e9rrez","year":"2013","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.bbih.2019.100003_bib42","doi-asserted-by":"crossref","DOI":"10.1111\/spc3.12471","article-title":"Why inflammation and the activities of the immune system matter for social and personality psychology (and not only for those who study health)","author":"Gassen","year":"2019","journal-title":"Soc. Personal. Psychol. Compass"},{"key":"10.1016\/j.bbih.2019.100003_bib43","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jaut.2013.05.005","article-title":"Immunological and autoimmune considerations of autism spectrum disorders","volume":"44","author":"Gesundheit","year":"2013","journal-title":"J.\u00a0Autoimmun."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib44","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/s12888-016-1177-y","article-title":"Is treatment-resistant schizophrenia categorically distinct from treatment-responsive schizophrenia? A systematic review","volume":"17","author":"Gillespie","year":"2017","journal-title":"BMC Psychiatr."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib45","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1038\/nri1571","article-title":"Stress-induced immune dysfunction: implications for health","volume":"5","author":"Glaser","year":"2005","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2019.100003_bib46","doi-asserted-by":"crossref","first-page":"127","DOI":"10.3389\/fnbeh.2018.00127","article-title":"A\u00a0comprehensive overview on stress neurobiology: basic concepts and clinical implications","volume":"12","author":"Godoy","year":"2018","journal-title":"Front. Behav. Neurosci."},{"issue":"4314025","key":"10.1016\/j.bbih.2019.100003_bib47","article-title":"Evidence of mitochondrial dysfunction in autism: biochemical links, genetic-based associations, and non-energy-related mechanisms","volume":"2017","author":"Griffiths","year":"2017","journal-title":"Oxidative Med. Cell. Longev."},{"issue":"35","key":"10.1016\/j.bbih.2019.100003_bib48","doi-asserted-by":"crossref","first-page":"12217","DOI":"10.1523\/JNEUROSCI.1053-15.2015","article-title":"Inflammatory pain promotes increased opioid self-administration: role of dysregulated ventral tegmental area \u03bc opioid receptors","volume":"35","author":"Hip\u00f3lito","year":"2015","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbih.2019.100003_bib49","doi-asserted-by":"crossref","first-page":"1211","DOI":"10.1038\/mp.2013.96","article-title":"Response of the [mu]-opioid system to social rejection and acceptance","volume":"18","author":"Hsu","year":"2013","journal-title":"Mol. Psychiatr."},{"issue":"9b","key":"10.1016\/j.bbih.2019.100003_bib50","doi-asserted-by":"crossref","first-page":"3591","DOI":"10.1111\/j.1582-4934.2008.00535.x","article-title":"Epigenetic programming of \u03bc-opioid receptor gene in mouse brain is regulated by MeCP2 and brg1 chromatin remodelling factor","volume":"13","author":"Hwang","year":"2009","journal-title":"J.\u00a0Cell Mol. Med."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib51","doi-asserted-by":"crossref","first-page":"3222","DOI":"10.1016\/j.neuroimage.2011.10.090","article-title":"Inflammation selectively enhances amygdala activity to socially threatening images","volume":"59","author":"Inagaki","year":"2012","journal-title":"Neuroimage"},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib52","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1016\/S0031-9384(03)00148-3","article-title":"Is social attachment an addictive disorder?","volume":"79","author":"Insel","year":"2003","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbih.2019.100003_bib53","series-title":"Post by former NIMH director Thomas Insel: transforming diagnosis [blog post]","author":"Insel","year":"2013"},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib1","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1124\/jpet.105.091991","article-title":"Antiexudative effects of opioids and expression of \u03ba-and \u03b4-opioid receptors during intestinal inflammation in mice: involvement of nitric oxide","volume":"316","author":"Jim\u00e9nez","year":"2006","journal-title":"J.\u00a0Pharmacol. Exp. Ther."},{"key":"10.1016\/j.bbih.2019.100003_bib54","first-page":"25267","article-title":"Pain tolerance predicts human social network size","volume":"6","author":"Johnson","year":"2016","journal-title":"Scient. Rpts"},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib55","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1001\/jamapsychiatry.2015.1977","article-title":"Inflammation and specific symptoms of depression","volume":"73","author":"Jokela","year":"2016","journal-title":"JAMA Psychiatr."},{"issue":"7","key":"10.1016\/j.bbih.2019.100003_bib56","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopsych.2005.08.001","article-title":"Cortisol, the cortisol-dehydroepiandrosterone ratio, and pro-inflammatory cytokines in patients with current major depressive disorder comorbid with borderline personality disorder","volume":"59","author":"Kahl","year":"2006","journal-title":"Biol. Psychiatr."},{"issue":"7","key":"10.1016\/j.bbih.2019.100003_bib57","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1016\/0306-4530(95)00023-2","article-title":"Opiate systems in mother and infant primates coordinate intimate contact during reunion","volume":"20","author":"Kalin","year":"1995","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib58","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1111\/acps.12959","article-title":"Clinical factors predicting treatment resistant depression: affirmative results from the European multicenter study","volume":"139","author":"Kautzky","year":"2019","journal-title":"Acta Psychiatr. Scand."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib59","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1037\/a0032329","article-title":"Modulation of male song by naloxone in the medial preoptic nucleus","volume":"127","author":"Kelm-Nelson","year":"2013","journal-title":"Behav. Neurosci."},{"issue":"433","key":"10.1016\/j.bbih.2019.100003_bib60","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1111\/j.1600-0447.2007.00966.x","article-title":"Epidemiology of subtypes of depression","volume":"115","author":"Kessing","year":"2007","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.bbih.2019.100003_bib61","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0306-4530(89)90065-6","article-title":"Beta-endorphin concentrations in cerebrospinal fluid of monkeys are influenced by grooming relationships","volume":"14","author":"Keverne","year":"1989","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"10.1016\/j.bbih.2019.100003_bib62","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1292\/jvms.12-0454","article-title":"Naloxone blocks the deterioration of male sexual behavior induced by alarm pheromone in rats","volume":"75","author":"Kobayashi","year":"2013","journal-title":"J.\u00a0Vet. Med. Sci."},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib63","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1097\/00004583-199502000-00018","article-title":"Naltrexone in young autistic children: a double-blind, placebo-controlled crossover study","volume":"34","author":"Kolmen","year":"1995","journal-title":"J.\u00a0Am. Acad. Child Adolesc. Psychiatry"},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib64","article-title":"The common pathophysiology underlying the metabolic syndrome, schizophrenia and depression. A review","volume":"159","author":"Kucerova","year":"2015","journal-title":"Biomed. Pap. Med. Facult. Palacky Univ. Olomouc"},{"key":"10.1016\/j.bbih.2019.100003_bib65","first-page":"455","article-title":"Depression subtypes and inflammation: atypical rather than melancholic depression is linked with immunometabolic dysregulations","author":"Lamers","year":"2018","journal-title":"Inflamm. Immun. Depress."},{"issue":"7","key":"10.1016\/j.bbih.2019.100003_bib66","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1017\/S0033291717002483","article-title":"Metabolic and inflammatory markers: associations with individual depressive symptoms","volume":"48","author":"Lamers","year":"2018","journal-title":"Psychol. Med."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib67","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1017\/S2045796013000498","article-title":"What is in a name? Renaming schizophrenia as a starting point for moving ahead with its re-conceptualization","volume":"22","author":"Lasalvia","year":"2013","journal-title":"Epidemiol. Psychiatr. Sci."},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib68","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1038\/mp.2016.81","article-title":"Disrupted habenula function in major depression","volume":"22","author":"Lawson","year":"2017","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2019.100003_bib69","doi-asserted-by":"crossref","first-page":"742","DOI":"10.3389\/fnins.2018.00742","article-title":"Transcriptomic characterization of the human habenula highlights drug metabolism and the neuroimmune system","volume":"12","author":"Le Foll","year":"2018","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib70","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.jagp.2016.09.009","article-title":"Inflammation in schizophrenia: cytokine levels and their relationships to demographic and clinical variables","volume":"25","author":"Lee","year":"2017","journal-title":"Am. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.bbih.2019.100003_bib71","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/hup.618","article-title":"The epidemiology of pain in depression","volume":"19","author":"L\u00e9pine","year":"2004","journal-title":"Hum. Psychopharmacol. Clin. Exp."},{"key":"10.1016\/j.bbih.2019.100003_bib72","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.bbr.2014.04.042","article-title":"Pain and depression comorbidity: a preclinical perspective","volume":"276","author":"Li","year":"2015","journal-title":"Behav. Brain Res."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib73","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1007\/s11481-009-9145-7","article-title":"Inducible expression of functional mu opioid receptors in murine dendritic cells","volume":"4","author":"Li","year":"2009","journal-title":"J.\u00a0Neuroimmune Pharmacol."},{"key":"10.1016\/j.bbih.2019.100003_bib74","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/j.expneurol.2016.08.010","article-title":"Why depression and pain often coexist and mutually reinforce: role of the lateral habenula","volume":"284","author":"Li","year":"2016","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbih.2019.100003_bib75","doi-asserted-by":"crossref","first-page":"31","DOI":"10.3389\/fnbeh.2017.00031","article-title":"Role of the lateral habenula in pain-associated depression","volume":"11","author":"Li","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbih.2019.100003_bib76","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/j.expneurol.2019.05.005","article-title":"Hypoactivity of the lateral habenula contributes to negative symptoms and cognitive dysfunction of schizophrenia in rats","volume":"318","author":"Li","year":"2019","journal-title":"Exp. Neurol."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib77","first-page":"5","article-title":"Opioid system modulates the immune function: a review","volume":"1","author":"Liang","year":"2016","journal-title":"Transl. Perioper. Pain Med."},{"key":"10.1016\/j.bbih.2019.100003_bib157","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.2147\/NDT.S147317","article-title":"Atypical depression: current perspectives","volume":"13","author":"\u0141ojko","year":"2017","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.bbih.2019.100003_bib78","doi-asserted-by":"crossref","first-page":"430","DOI":"10.3389\/fnbeh.2014.00430","article-title":"State-dependent \u03bc-opioid modulation of social motivation\u2013a model","volume":"8","author":"L\u00f8seth","year":"2014","journal-title":"Front. Behav. Neurosci."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2019.100003_bib79","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/S0006-8993(10)80036-8","article-title":"Further studies on interactions between periaqueductal gray, nucleus accumbens and habenula in antinociception","volume":"583","author":"Ma","year":"1992","journal-title":"Brain Res."},{"issue":"9\u201310","key":"10.1016\/j.bbih.2019.100003_bib80","doi-asserted-by":"crossref","first-page":"985","DOI":"10.1163\/000579511X596624","article-title":"The brain opioid theory of social attachment: a review of the evidence","volume":"148","author":"Machin","year":"2011","journal-title":"Behaviour"},{"issue":"12","key":"10.1016\/j.bbih.2019.100003_bib81","doi-asserted-by":"crossref","first-page":"2739","DOI":"10.1253\/circj.CJ-11-1184","article-title":"Chronic inflammation links cardiovascular, metabolic and renal diseases","volume":"75","author":"Manabe","year":"2011","journal-title":"Circ. J."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib82","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1017\/S1461145798001047","article-title":"Pain threshold is reduced in depression","volume":"1","author":"Marazziti","year":"1998","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"7","key":"10.1016\/j.bbih.2019.100003_bib83","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159097","article-title":"Mu opioid receptor actions in the lateral habenula","volume":"11","author":"Margolis","year":"2016","journal-title":"PloS one"},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib84","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/dev.420280202","article-title":"Effects of opioid receptor blockade on the social behavior of rhesus monkeys living in large family groups","volume":"28","author":"Martel","year":"1995","journal-title":"Dev. Psychobiol."},{"issue":"7203","key":"10.1016\/j.bbih.2019.100003_bib85","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1038\/nature07201","article-title":"Origin and physiological roles of inflammation","volume":"454","author":"Medzhitov","year":"2008","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib86","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1038\/npp.2016.158","article-title":"The role of the immune system in autism spectrum disorder","volume":"42","author":"Meltzer","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib87","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.pharmthera.2011.06.003","article-title":"Inflammatory processes in schizophrenia: a promising neuroimmunological target for the treatment of negative\/cognitive symptoms and beyond","volume":"132","author":"Meyer","year":"2011","journal-title":"Pharmacol. Ther."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib88","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1002\/da.22084","article-title":"Cytokine targets in the brain: impact on neurotransmitters and neurocircuits","volume":"30","author":"Miller","year":"2013","journal-title":"Depress. Anxiety"},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib89","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1111\/nyas.13864","article-title":"Effects of inflammation on social processes and implications for health","volume":"1428","author":"Moieni","year":"2018","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib90","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1006\/nimg.1999.0455","article-title":"Covariation of activity in habenula and dorsal raphe nuclei following tryptophan depletion","volume":"10","author":"Morris","year":"1999","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbih.2019.100003_bib91","doi-asserted-by":"crossref","first-page":"372","DOI":"10.3389\/fnins.2015.00372","article-title":"The role of inflammation in schizophrenia","volume":"9","author":"M\u00fcller","year":"2015","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib92","doi-asserted-by":"crossref","first-page":"18","DOI":"10.4306\/pi.2016.13.1.18","article-title":"Bipolar disorder: role of inflammation and the development of disease biomarkers","volume":"13","author":"Muneer","year":"2016","journal-title":"Psychiatr. Investig."},{"key":"10.1016\/j.bbih.2019.100003_bib93","article-title":"A\u00a0review of the conceptualisation and risk factors associated with treatment-resistant depression","volume":"2017","author":"Murphy","year":"2017","journal-title":"Depress. Res. Treat."},{"issue":"6","key":"10.1016\/j.bbih.2019.100003_bib163","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1177\/1745691615600138","article-title":"Does oxytocin increase trust in humans? A critical review of research","volume":"10","author":"Nave","year":"2015","journal-title":"Perspectives on Psychological Science"},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib94","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1016\/S0149-7634(97)00052-3","article-title":"Brain substrates of infant\u2013mother attachment: contributions of opioids, oxytocin, and norepinephrine","volume":"22","author":"Nelson","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"8","key":"10.1016\/j.bbih.2019.100003_bib95","first-page":"17","article-title":"Prevalence and management of treatment-resistant depression","volume":"68","author":"Nemeroff","year":"2007","journal-title":"J.\u00a0Clin. Psychiatry"},{"key":"10.1016\/j.bbih.2019.100003_bib96","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/j.pbb.2013.04.015","article-title":"Morphine dependence and withdrawal induced changes in cholinergic signaling","volume":"109","author":"Neugebauer","year":"2013","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"Suppl. l_1","key":"10.1016\/j.bbih.2019.100003_bib97","doi-asserted-by":"crossref","first-page":"i4","DOI":"10.1093\/bja\/aeu090","article-title":"Morphine stimulates cancer progression and mast cell activation and impairs survival in transgenic mice with breast cancer","volume":"113","author":"Nguyen","year":"2014","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbih.2019.100003_bib98","series-title":"Symptoms: depression","author":"NHS","year":"2016"},{"issue":"14","key":"10.1016\/j.bbih.2019.100003_bib99","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1097\/00001756-199909290-00026","article-title":"Social defeat stress increases expression of \u03bc-opioid receptor mRNA in rat ventral tegmental area","volume":"10","author":"Nikulina","year":"1999","journal-title":"Neuroreport"},{"issue":"6","key":"10.1016\/j.bbih.2019.100003_bib100","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1038\/sj.npp.1300658","article-title":"Prolonged effects of repeated social defeat stress on mRNA expression and function of \u03bc-opioid receptors in the ventral tegmental area of rats","volume":"30","author":"Nikulina","year":"2005","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbih.2019.100003_bib101","doi-asserted-by":"crossref","first-page":"3621","DOI":"10.1002\/hbm.22866","article-title":"Adult attachment style is associated with cerebral \u03bc-opioid receptor availability in humans","volume":"36","author":"Nummenmaa","year":"2015","journal-title":"Human Brain Mapp"},{"issue":"21","key":"10.1016\/j.bbih.2019.100003_bib102","doi-asserted-by":"crossref","first-page":"4751","DOI":"10.1093\/hmg\/dds314","article-title":"Genetic\u2013epigenetic interaction modulates \u03bc-opioid receptor regulation","volume":"21","author":"Oertel","year":"2012","journal-title":"Hum. Mol. Genet."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib103","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/j.bbi.2011.08.007","article-title":"The role of immune dysfunction in the pathophysiology of autism","volume":"26","author":"Onore","year":"2012","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib104","first-page":"15","article-title":"Emotions as viewed by psychoanalysis and neuroscience: an exercise in consilience","volume":"1","author":"Panksepp","year":"1999","journal-title":"Neuro-psychoanalysis"},{"key":"10.1016\/j.bbih.2019.100003_bib105","first-page":"607","article-title":"The biology of social attachments: opiates alleviate separation distress","volume":"13","author":"Panksepp","year":"1978","journal-title":"Biol. Psychiatr."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib106","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/0149-7634(80)90036-6","article-title":"Endogenous opioids and social behavior","volume":"4","author":"Panksepp","year":"1980","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"5","key":"10.1016\/j.bbih.2019.100003_bib107","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/0091-3057(80)90011-8","article-title":"Opioid blockade and social comfort in chicks","volume":"13","author":"Panksepp","year":"1980","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbih.2019.100003_bib108","series-title":"The psychobiology of prosocial behaviors: separation distress, play and altruism. Altruism and Aggression: social and biological origins","author":"Panksepp","year":"1986"},{"issue":"6","key":"10.1016\/j.bbih.2019.100003_bib109","doi-asserted-by":"crossref","first-page":"554","DOI":"10.1016\/j.euroneuro.2017.04.001","article-title":"Why are depressed patients inflamed? A reflection on 20 years of research on depression, glucocorticoid resistance and inflammation","volume":"27","author":"Pariante","year":"2017","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"9","key":"10.1016\/j.bbih.2019.100003_bib110","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.tins.2008.06.006","article-title":"The HPA axis in major depression: classical theories and new developments","volume":"31","author":"Pariante","year":"2008","journal-title":"Trends Neurosci."},{"issue":"5","key":"10.1016\/j.bbih.2019.100003_bib111","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1016\/S0006-3223(00)01088-X","article-title":"Glucocorticoid receptors in major depression: relevance to pathophysiology and treatment","volume":"49","author":"Pariante","year":"2001","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.bbih.2019.100003_bib112","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.brainres.2013.04.004","article-title":"Infusion of endomorphin-1 (EM-1) in the MPOA and the Me modulate sexual and socio-sexual behavior in the male rat","volume":"1517","author":"Parra-G\u00e1mez","year":"2013","journal-title":"Brain Res."},{"key":"10.1016\/j.bbih.2019.100003_bib113","doi-asserted-by":"crossref","first-page":"2750","DOI":"10.1111\/bph.13808","article-title":"\u03bc opioid receptor, social behaviour and autism spectrum disorder: reward matters","volume":"175","author":"Pellissier","year":"2018","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbih.2019.100003_bib114","doi-asserted-by":"crossref","first-page":"S62","DOI":"10.1016\/j.euroneuro.2017.12.090","article-title":"Clinical heterogeneity in major depressive disorder","volume":"28","author":"Penninx","year":"2018","journal-title":"Eur. Neuropsychopharmacol."},{"issue":"7","key":"10.1016\/j.bbih.2019.100003_bib162","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1111\/ejn.12490","article-title":"Stress and VTA synapses: implications for addiction and depression","volume":"39","author":"Polter","year":"2014","journal-title":"Eur. J. Neurosci."},{"issue":"14","key":"10.1016\/j.bbih.2019.100003_bib159","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1111\/bph.13750","article-title":"Opioids and the immune system-friend or foe","volume":"175","author":"Plein","year":"2018","journal-title":"Br. J. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib115","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s12974-017-0938-y","article-title":"Bridging autism spectrum disorders and schizophrenia through inflammation and biomarkers-pre-clinical and clinical investigations","volume":"14","author":"Prata","year":"2017","journal-title":"J.\u00a0Neuroinflammation"},{"issue":"6","key":"10.1016\/j.bbih.2019.100003_bib116","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1097\/01.pra.0000407965.34604.4a","article-title":"What do the terms \u201cdrug-specific response\/remission rate\u201d and \u201cplacebo\u201d really mean?","volume":"17","author":"Preskorn","year":"2011","journal-title":"J.\u00a0Psychiatr. Pract\u00ae"},{"key":"10.1016\/j.bbih.2019.100003_bib117","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1016\/j.neuroscience.2014.11.053","article-title":"The effects of morphine, naloxone, and \u03ba opioid manipulation on endocrine functioning and social behavior in monogamous titi monkeys (Callicebus cupreus)","volume":"287","author":"Ragen","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbih.2019.100003_bib118","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/mp.2012.2","article-title":"The evolutionary significance of depression in Pathogen Host Defense (PATHOS-D)","volume":"18","author":"Raison","year":"2013","journal-title":"Mol. Psychiatr."},{"issue":"21","key":"10.1016\/j.bbih.2019.100003_bib119","doi-asserted-by":"crossref","first-page":"9140","DOI":"10.1523\/JNEUROSCI.4123-12.2013","article-title":"\u03bc-Opioid receptors within subregions of the striatum mediate pair bond formation through parallel yet distinct reward mechanisms","volume":"33","author":"Resendez","year":"2013","journal-title":"J.\u00a0Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib120","first-page":"125","article-title":"Bipolar disorder and inflammation","volume":"39","author":"Rosenblat","year":"2016","journal-title":"Psychiatr. Clin."},{"key":"10.1016\/j.bbih.2019.100003_bib121","doi-asserted-by":"crossref","first-page":"150","DOI":"10.3389\/fphys.2014.00150","article-title":"Evidence linking oxidative stress, mitochondrial dysfunction, and inflammation in the brain of individuals with autism","volume":"5","author":"Rossignol","year":"2014","journal-title":"Front. Physiol."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib122","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1007\/s11481-005-9009-8","article-title":"Modulation of immune function by morphine: implications for susceptibility to infection","volume":"1","author":"Roy","year":"2006","journal-title":"J.\u00a0Neuroimmune Pharmacol."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib123","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1111\/jir.12122","article-title":"Are opioid antagonists effective in attenuating the core symptoms of autism spectrum conditions in children: a systematic review","volume":"59","author":"Roy","year":"2015","journal-title":"J.\u00a0Intellect. Disabil. Res."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2019.100003_bib124","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.psychres.2014.02.016","article-title":"Elevated IL-6 levels in patients with atypical depression but not in patients with typical depression","volume":"217","author":"Rudolf","year":"2014","journal-title":"Psychiatry Res."},{"issue":"8","key":"10.1016\/j.bbih.2019.100003_bib125","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1191\/0269216306pm1124oa","article-title":"Opioids and the immune system","volume":"20","author":"Sacerdote","year":"2006","journal-title":"Palliat. Med."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib126","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1080\/17522439.2017.1344294","article-title":"Pain perception in people diagnosed with schizophrenia: where we are and where we are going","volume":"9","author":"Sakson-Obada","year":"2017","journal-title":"Psychosis"},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib127","doi-asserted-by":"crossref","first-page":"366","DOI":"10.3390\/ph4020366","article-title":"Opioid antagonists may reverse endogenous opiate \u201cdependence\u201d in the treatment of self-injurious behavior","volume":"4","author":"Sandman","year":"2011","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbih.2019.100003_bib128","doi-asserted-by":"crossref","first-page":"16734","DOI":"10.1074\/jbc.M112.347583","article-title":"Opiate antagonist prevents \u03bc-and \u03b4-opiate receptor dimerization to facilitate ability of agonist to control ethanol-altered natural natural killer cell functions and mammary tumor growth","volume":"287","author":"Sarkar","year":"2012","journal-title":"J.\u00a0Biol. Chem."},{"issue":"6","key":"10.1016\/j.bbih.2019.100003_bib129","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1016\/j.cell.2009.04.019","article-title":"Dissociation of the opioid receptor mechanisms that control mechanical and heat pain","volume":"137","author":"Scherrer","year":"2009","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib130","first-page":"351","article-title":"Opioid-immune interactions in autism: behavioural and immunological assessment during a double-blind treatment with naltrexone","volume":"32","author":"Scifo","year":"1996","journal-title":"Annali dell\u2019Istituto superiore di sanita"},{"issue":"17","key":"10.1016\/j.bbih.2019.100003_bib131","doi-asserted-by":"crossref","first-page":"5876","DOI":"10.1523\/JNEUROSCI.3604-09.2010","article-title":"Differential neuromodulation of acquisition and retrieval of avoidance learning by the lateral habenula and ventral tegmental area","volume":"30","author":"Shumake","year":"2010","journal-title":"J.\u00a0Neurosci."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib132","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1037\/a0035302","article-title":"From stress to inflammation and major depressive disorder: a social signal transduction theory of depression","volume":"140","author":"Slavich","year":"2014","journal-title":"Psychol. Bull."},{"issue":"8","key":"10.1016\/j.bbih.2019.100003_bib133","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1001\/jamapsychiatry.2015.0486","article-title":"Serotonin states and social anxiety","volume":"72","author":"Stein","year":"2015","journal-title":"JAMA Psychiatr."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib134","doi-asserted-by":"crossref","first-page":"840","DOI":"10.1016\/j.rasd.2009.01.007","article-title":"Autism and immune factors: a comprehensive review","volume":"3","author":"Stigler","year":"2009","journal-title":"Res. Autism Spectr. Disord."},{"issue":"11","key":"10.1016\/j.bbih.2019.100003_bib135","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1097\/j.pain.0000000000000304","article-title":"Decreased pain sensitivity among people with schizophrenia: a meta-analysis of experimental pain induction studies","volume":"156","author":"Stubbs","year":"2015","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib136","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.psychres.2011.07.006","article-title":"Inflammation in psychotic disorders: a population-based study","volume":"189","author":"Suvisaari","year":"2011","journal-title":"Psychiatry Res."},{"key":"10.1016\/j.bbih.2019.100003_bib137","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1001\/jamapsychiatry.2013.272","article-title":"Microglial activation in young adults with autism spectrum disorder","volume":"70","author":"Suzuki","year":"2013","journal-title":"JAMA Psychiatr."},{"key":"10.1016\/j.bbih.2019.100003_bib138","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neulet.2016.02.060","article-title":"Mu-Opioid (MOP) receptor mediated G-protein signaling is impaired in specific brain regions in a rat model of schizophrenia","volume":"619","author":"Sz\u0171cs","year":"2016","journal-title":"Neurosci. Lett."},{"key":"10.1016\/j.bbih.2019.100003_bib139","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.neures.2016.11.002","article-title":"Infection and inflammation in schizophrenia and bipolar disorder","volume":"115","author":"Tanaka","year":"2017","journal-title":"Neurosci. Res."},{"issue":"10","key":"10.1016\/j.bbih.2019.100003_bib140","doi-asserted-by":"crossref","first-page":"20150767","DOI":"10.1098\/rsbl.2015.0767","article-title":"Synchrony and exertion during dance independently raise pain threshold and encourage social bonding","volume":"11","author":"Tarr","year":"2015","journal-title":"Biol. Lett."},{"issue":"5","key":"10.1016\/j.bbih.2019.100003_bib141","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.evolhumbehav.2016.02.004","article-title":"Silent disco: dancing in synchrony leads to elevated pain thresholds and social closeness","volume":"37","author":"Tarr","year":"2016","journal-title":"Evol. Hum. Behav."},{"issue":"12","key":"10.1016\/j.bbih.2019.100003_bib142","first-page":"1257","article-title":"Is pain perception altered in people with depression? A systematic review and meta-analysis of experimental pain research","volume":"17","author":"Thompson","year":"2016","journal-title":"J.\u00a0Pain"},{"key":"10.1016\/j.bbih.2019.100003_bib143","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.2147\/NDT.S87666","article-title":"Pain perception in schizophrenia: influence of neuropeptides, cognitive disorders, and negative symptoms","volume":"11","author":"Urban-Kowalczyk","year":"2015","journal-title":"Neuropsychiatric Dis. Treat."},{"issue":"2","key":"10.1016\/j.bbih.2019.100003_bib160","first-page":"240","article-title":"Depression and schizophrenia: cause, consequence, or trans-diagnostic issue?","volume":"43","author":"Upthegrove","year":"2017","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbih.2019.100003_bib144","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1017\/S0033291798008162","article-title":"A\u00a0comparison of the utility of dimensional and categorical representations of psychosis. UK700 Group","volume":"29","author":"van Os","year":"1999","journal-title":"Psychol. Med."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib145","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/0014-2999(95)00040-R","article-title":"\u03bc-and \u03ba-opioid receptor-meiated opioid effects on social play in juvenile rats","volume":"276","author":"Vanderschuren","year":"1995","journal-title":"Eur. J. Pharmacol."},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib146","doi-asserted-by":"crossref","first-page":"e249","DOI":"10.1038\/tp.2013.27","article-title":"Anxiety disorders and inflammation in a large adult cohort","volume":"3","author":"Vogelzangs","year":"2013","journal-title":"Transl. Psychiatr."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib147","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.neuron.2018.03.002","article-title":"Functional divergence of delta and mu opioid receptor organization in CNS pain circuits","volume":"98","author":"Wang","year":"2018","journal-title":"Neuron"},{"issue":"52","key":"10.1016\/j.bbih.2019.100003_bib148","article-title":"IL-6 is increased in the cerebellum of autistic brain and alters neural cell adhesion, migration and synaptic formation","volume":"8","author":"Wei","year":"2011","journal-title":"J.\u00a0Neuroinflammation"},{"issue":"4","key":"10.1016\/j.bbih.2019.100003_bib149","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/S2215-0366(15)00575-1","article-title":"Predictors of treatment resistance in patients with schizophrenia: a population-based cohort study","volume":"3","author":"Wimberley","year":"2016","journal-title":"Lancet Psychiatr."},{"issue":"1","key":"10.1016\/j.bbih.2019.100003_bib150","doi-asserted-by":"crossref","first-page":"E76","DOI":"10.1208\/aapsj080109","article-title":"CNS drug delivery: opioid peptides and the blood-brain barrier","volume":"8","author":"Witt","year":"2006","journal-title":"AAPS J."},{"issue":"3","key":"10.1016\/j.bbih.2019.100003_bib151","doi-asserted-by":"crossref","first-page":"1068","DOI":"10.4049\/jimmunol.123.3.1068","article-title":"Suggestive evidence for receptors for morphine and methionine-enkephalin on normal human blood T lymphocytes","volume":"123","author":"Wybran","year":"1979","journal-title":"J.\u00a0Immunol."},{"key":"10.1016\/j.bbih.2019.100003_bib152","doi-asserted-by":"crossref","first-page":"636","DOI":"10.3389\/fnhum.2017.00636","article-title":"Altered volume and functional connectivity of the Habenula in Schizophrenia","volume":"11","author":"Zhang","year":"2017","journal-title":"Front. Hum. Neurosci."},{"issue":"8","key":"10.1016\/j.bbih.2019.100003_bib153","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1002\/aur.1977","article-title":"Association between schizophrenia and autism spectrum disorder: a systematic review and meta-analysis","volume":"11","author":"Zheng","year":"2018","journal-title":"Autism Res."},{"issue":"5528","key":"10.1016\/j.bbih.2019.100003_bib154","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1126\/science.1060952","article-title":"Regional mu opioid receptor regulation of sensory and affective dimensions of pain","volume":"293","author":"Zubieta","year":"2001","journal-title":"Science"},{"issue":"5610","key":"10.1016\/j.bbih.2019.100003_bib155","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1126\/science.1078546","article-title":"COMT val158met genotype affects \u03bc-opioid neurotransmitter responses to a pain stressor","volume":"299","author":"Zubieta","year":"2003","journal-title":"Science"},{"issue":"11","key":"10.1016\/j.bbih.2019.100003_bib156","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1001\/archpsyc.60.11.1145","article-title":"Regulation of human affective responses by anterior cingulate and limbic \u03bc-opioid neurotransmission","volume":"60","author":"Zubieta","year":"2003","journal-title":"Arch. Gen. Psychiatr."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354619300031?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354619300031?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:19:20Z","timestamp":1762985960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354619300031"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,1]]},"references-count":166,"alternative-id":["S2666354619300031"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2019.100003","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2020,1]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"The aetiology of social deficits within mental health disorders: The role of the immune system and endogenous opioids","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2019.100003","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2019 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100003"}}