{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,30]],"date-time":"2026-04-30T09:17:23Z","timestamp":1777540643460,"version":"3.51.4"},"reference-count":108,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,1,29]],"date-time":"2020-01-29T00:00:00Z","timestamp":1580256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.bbih.2020.100043","type":"journal-article","created":{"date-parts":[[2020,1,30]],"date-time":"2020-01-30T11:45:31Z","timestamp":1580384731000},"page":"100043","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":24,"special_numbering":"C","title":["Therapeutic efficacy of environmental enrichment on behavioral, endocrine, and synaptic alterations in an animal model of maternal immune activation"],"prefix":"10.1016","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5796-8034","authenticated-orcid":false,"given":"Xin","family":"Zhao","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3297-8623","authenticated-orcid":false,"given":"Alejandro N.","family":"Rond\u00f3n-Ortiz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Erika P.","family":"Lima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Madeline","family":"Puracchio","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryland C.","family":"Roderick","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7069-486X","authenticated-orcid":false,"given":"Amanda C.","family":"Kentner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbih.2020.100043_bib1","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/dneu.20765","article-title":"Postsynaptic BDNF-TrkB signaling in synapse maturation, plasticity, and disease","volume":"70","author":"Yoshii","year":"2010","journal-title":"Dev. Neurobiol."},{"issue":"6","key":"10.1016\/j.bbih.2020.100043_bib2","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1001\/archpsyc.60.6.565","article-title":"Sex differences in the risk of schizophrenia: evidence from meta-analysis","volume":"60","author":"Aleman","year":"2003","journal-title":"Arch. Gen. Psychiatr."},{"issue":"5","key":"10.1016\/j.bbih.2020.100043_bib3","doi-asserted-by":"crossref","first-page":"927","DOI":"10.1176\/ajp.2006.163.5.927","article-title":"Prenatal exposure to maternal genital and reproductive infections and adult schizophrenia","volume":"163","author":"Babulas","year":"2006","journal-title":"Am. J. Psychiatr."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib4","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1196\/annals.1296.033","article-title":"Prenatal immune challenge affects growth, behavior, and brain dopamine in offspring","volume":"1018","author":"Bakos","year":"2004","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib5","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/j.neuroscience.2009.08.054","article-title":"Enriched environment influences hormonal status and hippocampal brain derived neurotrophic factor in a sex dependent manner","volume":"164","author":"Bakos","year":"2009","journal-title":"Neuroscience"},{"issue":"11","key":"10.1016\/j.bbih.2020.100043_bib6","doi-asserted-by":"crossref","first-page":"2837","DOI":"10.1523\/JNEUROSCI.4447-07.2008","article-title":"NMDA receptor plasticity in the perirhinal and prefrontal cortices is crucial for the acquisition of long-term object-in-place associative memory","volume":"28","author":"Barker","year":"2008","journal-title":"J.\u00a0Neurosci."},{"issue":"29","key":"10.1016\/j.bbih.2020.100043_bib7","doi-asserted-by":"crossref","first-page":"10721","DOI":"10.1523\/JNEUROSCI.6413-10.2011","article-title":"When is the hippocampus involved in recognition memory?","volume":"31","author":"Barker","year":"2011","journal-title":"J.\u00a0Neurosci."},{"issue":"11","key":"10.1016\/j.bbih.2020.100043_bib8","doi-asserted-by":"crossref","first-page":"2948","DOI":"10.1523\/JNEUROSCI.5289-06.2007","article-title":"Recognition memory for objects, place, and temporal order: a disconnection analysis of the role of the medial prefrontal cortex and perirhinal cortex","volume":"27","author":"Barker","year":"2007","journal-title":"J.\u00a0Neurosci."},{"issue":"2\u20133","key":"10.1016\/j.bbih.2020.100043_bib9","doi-asserted-by":"crossref","first-page":"586","DOI":"10.1016\/j.ejphar.2010.09.083","article-title":"Hyperactivity of the hypothalamus\u2013pituitary\u2013adrenal axis in lipopolysaccharide-induced neurodevelopmental model of schizophrenia in rats: effects of antipsychotic drugs","volume":"650","author":"Basta-Kaim","year":"2011","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib10","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1016\/j.neubiorev.2010.07.002","article-title":"Sex bias in neuroscience and biomedical research","volume":"35","author":"Beery","year":"2011","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib11","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1113\/jphysiol.2002.031369","article-title":"PSD-95 regulates synaptic transmission and plasticity in rat cerebral cortex","volume":"546","author":"B\u00e9\u00efque","year":"2003","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bbih.2020.100043_bib12","doi-asserted-by":"crossref","first-page":"S186","DOI":"10.1016\/j.psyneuen.2009.05.021","article-title":"The role of FKBP5, a co-chaperone of the glucocorticoid receptor in the pathogenesis and therapy of affective and anxiety disorders","volume":"34","author":"Binder","year":"2009","journal-title":"Psychoneuroendocrinology"},{"issue":"6","key":"10.1016\/j.bbih.2020.100043_bib13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.1016\/j.bbi.2010.03.005","article-title":"Effects of prenatal infection on brain development and behavior: a review of findings from animal models","volume":"24","author":"Boksa","year":"2010","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.bbih.2020.100043_bib14","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0031-9384(95)02043-8","article-title":"Effects of housing on male and female rats: crowding stresses males but calms females","volume":"58","author":"Brown","year":"1995","journal-title":"Physiol. Behav."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib16","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.psychres.2003.12.014","article-title":"Impaired performance in a working memory binding task in patients with schizophrenia","volume":"125","author":"Burglen","year":"2004","journal-title":"Psychiatr. Res."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib17","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1203\/00006450-200001000-00013","article-title":"Cytokine induction in fetal rat brains and brain injury in neonatal rats after maternal lipopolysaccharide administration","volume":"47","author":"Cai","year":"2000","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbih.2020.100043_bib18","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/j.neuroscience.2012.06.016","article-title":"The impact of environmental enrichment on sex-specific neurochemical circuitries\u2013effects on brain-derived neurotrophic factor and the serotonergic system","volume":"220","author":"Chourbaji","year":"2012","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41398-019-0423-8","article-title":"Sex and gender bias in the experimental neurosciences: the case of the maternal immune activation model","volume":"9","author":"Coiro","year":"2019","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbih.2020.100043_bib21","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.bbi.2015.07.022","article-title":"Impaired synaptic development in a maternal immune activation mouse model of neurodevelopmental disorders","volume":"50","author":"Coiro","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2020.100043_bib22","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.bbi.2014.06.020","article-title":"Environmental enrichment mitigates the sex-specific effects of gestational inflammation on social engagement and the hypothalamic pituitary adrenal axis-feedback system","volume":"42","author":"Connors","year":"2014","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2020.100043_bib23","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/j.psyneuen.2014.10.021","article-title":"Environmental enrichment models a naturalistic form of maternal separation and shapes the anxiety response patterns of offspring","volume":"52","author":"Connors","year":"2015","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2020.100043_bib24","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.bbi.2016.12.008","article-title":"Evolution of structural abnormalities in the rat brain following in utero exposure to maternal immune activation: a longitudinal in vivo MRI study","volume":"63","author":"Crum","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2020.100043_bib25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.3389\/neuro.08.025.2009","article-title":"Social enrichment during postnatal development induces transgenerational effects on emotional and reproductive behavior in mice","volume":"3","author":"Curley","year":"2009","journal-title":"Front. Behav. Neurosci."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib26","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/S0031-9384(98)00066-3","article-title":"Effects of strawbedding on physiological responses to stressors and behavior in growing pigs","volume":"64","author":"de Jong","year":"1998","journal-title":"Physiol. Behav."},{"issue":"10","key":"10.1016\/j.bbih.2020.100043_bib27","doi-asserted-by":"crossref","first-page":"2749","DOI":"10.1111\/j.1460-9568.2006.04798.x","article-title":"Anxiolytic-like effects of the selective metabotropic glutamate receptor 5 antagonist MPEP after its intra-amygdaloid microinjection in three different non-conditioned rat models of anxiety","volume":"23","author":"De La Mora","year":"2006","journal-title":"Eur. J. Neurosci."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib28","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1038\/nrn2055","article-title":"Regulatory mechanisms of AMPA receptors in synaptic plasticity","volume":"8","author":"Derkach","year":"2007","journal-title":"Nat. Rev. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib29","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/S0074-7742(04)59003-7","article-title":"The synaptic pathology of schizophrenia: is aberrant neurodevelopment and plasticity to blame","volume":"59","author":"Eastwood","year":"2004","journal-title":"Int. Rev. Neurobiol."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib30","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/WCO.0000000000000186","article-title":"Autism and the synapse: emerging mechanisms and mechanism-based therapies","volume":"28","author":"Ebrahimi-Fakhari","year":"2015","journal-title":"Curr. Opin. Neurol."},{"issue":"6","key":"10.1016\/j.bbih.2020.100043_bib31","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.ijdevneu.2011.02.011","article-title":"Intrauterine inflammation, insufficient to induce parturition, still evokes fetal and neonatal brain injury","volume":"29","author":"Elovitz","year":"2011","journal-title":"Int. J. Dev. Neurosci."},{"issue":"7","key":"10.1016\/j.bbih.2020.100043_bib32","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.1016\/j.bbi.2011.04.005","article-title":"Acute amygdaloid response to systemic inflammation","volume":"25","author":"Engler","year":"2011","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib33","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1006\/nlme.1995.1043","article-title":"Early environmental stimulation produces long-lasting changes on \u03b2-adrenoceptor transduction system","volume":"64","author":"Escorihuela","year":"1995","journal-title":"Neurobiol. Learn. Mem."},{"issue":"6301","key":"10.1016\/j.bbih.2020.100043_bib34","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1126\/science.aag3194","article-title":"Maternal immune activation: implications for neuropsychiatric disorders","volume":"353","author":"Estes","year":"2016","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib35","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1016\/0304-3940(92)90494-R","article-title":"Increased expression of brain-derived neurotrophic factor mRNA in rat hippocampus is associated with improved spatial memory and enriched environment","volume":"138","author":"Falkenberg","year":"1992","journal-title":"Neurosci. Lett."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib36","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1093\/schbul\/16.2.211","article-title":"Influence of gender in schizophrenia as related to other psychopathological syndromes","volume":"16","author":"Flor-Henry","year":"1990","journal-title":"Schizophr. Bull."},{"issue":"5","key":"10.1016\/j.bbih.2020.100043_bib37","doi-asserted-by":"crossref","first-page":"1838","DOI":"10.1523\/JNEUROSCI.17-05-01838.1997","article-title":"Activation of amygdala cholecystokininB receptors potentiates the acoustic startle response in the rat","volume":"17","author":"Frankland","year":"1997","journal-title":"J.\u00a0Neurosci."},{"issue":"6","key":"10.1016\/j.bbih.2020.100043_bib38","doi-asserted-by":"crossref","first-page":"R1024","DOI":"10.1152\/ajpregu.00664.2003","article-title":"Maternal LPS induces cytokines in the amniotic fluid and corticotropin releasing hormone in the fetal rat brain","volume":"286","author":"Gayle","year":"2004","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"key":"10.1016\/j.bbih.2020.100043_bib39","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.bbi.2015.09.015","article-title":"Prenatal immune activation causes hippocampal synaptic deficits in the absence of overt microglia anomalies","volume":"55","author":"Giovanoli","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.bbih.2020.100043_bib40","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/0031-9384(94)90341-7","article-title":"Effects of environmental enrichment on aggressive behavior, dominance hierarchies, and endocrine states in male DBA\/2J mice","volume":"56","author":"Haemisch","year":"1994","journal-title":"Physiol. Behav."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib41","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1016\/j.neuroscience.2010.01.006","article-title":"Prenatal exposure to lipopolysaccharide results in cognitive deficits in age-increasing offspring rats","volume":"166","author":"Hao","year":"2010","journal-title":"Neuroscience"},{"issue":"10","key":"10.1016\/j.bbih.2020.100043_bib42","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1002\/dneu.22043","article-title":"Prenatal and postnatal animal models of immune activation: relevance to a range of neurodevelopmental disorders","volume":"72","author":"Harvey","year":"2012","journal-title":"Dev. Neurobiol."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib43","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1002\/dev.20116","article-title":"Alterations in behavior in adult offspring mice following maternal inflammation during pregnancy","volume":"48","author":"Hava","year":"2006","journal-title":"Dev. Psychobiol."},{"issue":"4","key":"10.1016\/j.bbih.2020.100043_bib44","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1006\/anbe.1999.1390","article-title":"To nest communally or not to nest communally: a review of rodent communal nesting and nursing","volume":"59","author":"Hayes","year":"2000","journal-title":"Anim. Behav."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib45","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1177\/0269881114563634","article-title":"Glutamate and dopamine in schizophrenia: an update for the 21st century","volume":"29","author":"Howes","year":"2015","journal-title":"J.\u00a0Psychopharmacol."},{"key":"10.1016\/j.bbih.2020.100043_bib46","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1016\/j.neuroscience.2011.11.011","article-title":"Altered object-in-place recognition memory, prepulse inhibition, and locomotor activity in the offspring of rats exposed to a viral mimetic during pregnancy","volume":"201","author":"Howland","year":"2012","journal-title":"Neuroscience"},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib47","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1111\/nyas.12547","article-title":"The glutamate hypothesis of schizophrenia: evidence from human brain tissue studies","volume":"1338","author":"Hu","year":"2015","journal-title":"Ann. N. Y. Acad. Sci."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib48","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1006\/anbe.1996.0179","article-title":"Housing and welfare in laboratory rats: time-budgeting and pathophysiology in single-sex groups","volume":"52","author":"Hurst","year":"1996","journal-title":"Anim. Behav."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib49","doi-asserted-by":"crossref","first-page":"255","DOI":"10.3109\/09638288.2013.788218","article-title":"An enriched environment increases activity in stroke patients undergoing rehabilitation in a mixed rehabilitation unit: a pilot non-randomized controlled trial","volume":"36","author":"Janssen","year":"2014","journal-title":"Disabil. Rehabil."},{"issue":"8","key":"10.1016\/j.bbih.2020.100043_bib50","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1096\/fj.02-0333fje","article-title":"Long-lasting effects of neonatal dexamethasone treatment on spatial learning and hippocampal synaptic plasticity: involvement of the NMDA receptor complex","volume":"17","author":"Kamphuis","year":"2003","journal-title":"Faseb. J."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib51","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1113\/jphysiol.2005.090191","article-title":"Short periods of prenatal stress affect growth, behaviour and hypothalamo\u2013pituitary\u2013adrenal axis activity in male Guinea pig offspring","volume":"566","author":"Kapoor","year":"2005","journal-title":"J.\u00a0Physiol."},{"key":"10.1016\/j.bbih.2020.100043_bib52","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1016\/j.bbi.2016.03.013","article-title":"Environmental enrichment rescues the effects of early life inflammation on markers of synaptic transmission and plasticity","volume":"57","author":"Kentner","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2020.100043_bib53","doi-asserted-by":"crossref","first-page":"399","DOI":"10.1016\/j.neuroscience.2017.11.035","article-title":"Complex environmental rearing enhances social salience and affects hippocampal corticotropin releasing hormone receptor expression in a sex-specific manner","volume":"369","author":"Kentner","year":"2018","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib54","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1038\/s41386-018-0185-7","article-title":"Maternal immune activation: reporting guidelines to improve the rigor, reproducibility, and transparency of the model","volume":"44","author":"Kentner","year":"2019","journal-title":"Neuropsychopharmacology"},{"issue":"4","key":"10.1016\/j.bbih.2020.100043_bib55","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1159\/000290040","article-title":"Prenatal lipopolysaccharide reduces social behavior in male offspring","volume":"17","author":"Kirsten","year":"2010","journal-title":"Neuroimmunomodulation"},{"issue":"10","key":"10.1016\/j.bbih.2020.100043_bib56","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.1002\/jnr.23089","article-title":"Hypoactivity of the central dopaminergic system and autistic-like behavior induced by a single early prenatal exposure to lipopolysaccharide","volume":"90","author":"Kirsten","year":"2012","journal-title":"J.\u00a0Neurosci. Res."},{"issue":"12","key":"10.1016\/j.bbih.2020.100043_bib57","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0082244","article-title":"LPS exposure increases maternal corticosterone levels, causes placental injury and increases IL-1\u03b2 levels in adult rat offspring: relevance to autism","volume":"8","author":"Kirsten","year":"2013","journal-title":"PloS One"},{"issue":"11","key":"10.1016\/j.bbih.2020.100043_bib58","doi-asserted-by":"crossref","first-page":"643","DOI":"10.1038\/nrneurol.2014.187","article-title":"Maternal immune activation and abnormal brain development across CNS disorders","volume":"10","author":"Knuesel","year":"2014","journal-title":"Nat. Rev. Neurol."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib59","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0149-7634(97)00008-0","article-title":"Age, experience and the changing brain","volume":"22","author":"Kolb","year":"1998","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbih.2020.100043_bib60","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1016\/j.neuropharm.2013.04.005","article-title":"BDNF-induced local protein synthesis and synaptic plasticity","volume":"76","author":"Leal","year":"2014","journal-title":"Neuropharmacology"},{"issue":"13","key":"10.1016\/j.bbih.2020.100043_bib61","doi-asserted-by":"crossref","first-page":"3358","DOI":"10.1523\/JNEUROSCI.3642-17.2018","article-title":"Maternal and early postnatal immune activation produce dissociable effects on neurotransmission in mPFC\u2013amygdala circuits","volume":"38","author":"Li","year":"2018","journal-title":"J.\u00a0Neurosci."},{"issue":"4","key":"10.1016\/j.bbih.2020.100043_bib62","doi-asserted-by":"crossref","first-page":"282","DOI":"10.1139\/jpn.0429","article-title":"Using animal models to test a neurodevelopmental hypothesis of schizophrenia","volume":"29","author":"Lipska","year":"2004","journal-title":"J.\u00a0Psychiatry Neurosci."},{"key":"10.1016\/j.bbih.2020.100043_bib63","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.neuroscience.2015.04.048","article-title":"Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation","volume":"298","author":"MacRae","year":"2015","journal-title":"Neuroscience"},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib64","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1016\/S0018-506X(03)00002-3","article-title":"Effects of different forms of environmental enrichment on behavioral, endocrinological, and immunological parameters in male mice","volume":"43","author":"Marashi","year":"2003","journal-title":"Horm. Behav."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib65","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.pneurobio.2009.10.018","article-title":"Epidemiology-driven neurodevelopmental animal models of schizophrenia","volume":"90","author":"Meyer","year":"2010","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbih.2020.100043_bib66","series-title":"Applying Regression and Correlation: A Guide for Students and Researchers","author":"Miles","year":"2001"},{"issue":"5","key":"10.1016\/j.bbih.2020.100043_bib67","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1111\/j.1365-2826.2004.01173.x","article-title":"Effect of environmental enrichment on stress related systems in rats","volume":"16","author":"Moncek","year":"2004","journal-title":"J.\u00a0Neuroendocrinol."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib68","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1186\/s12883-014-0203-2","article-title":"GAME (Goals-Activity-Motor Enrichment): protocol of a single blind randomised controlled trial of motor training, parent education and environmental enrichment for infants at high risk of cerebral palsy","volume":"14","author":"Morgan","year":"2014","journal-title":"BMC Neurol."},{"issue":"6","key":"10.1016\/j.bbih.2020.100043_bib69","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1002\/cne.21162","article-title":"Ontogeny of hippocampal corticosteroid receptors: effects of antenatal glucocorticoids in human and mouse","volume":"499","author":"Noorlander","year":"2006","journal-title":"J.\u00a0Comp. Neurol."},{"key":"10.1016\/j.bbih.2020.100043_bib70","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1016\/j.bbi.2019.08.192","article-title":"Environmental influences on placental programming and offspring outcomes following maternal immune activation","volume":"83","author":"N\u00fa\u00f1ez Estevez","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"18","key":"10.1016\/j.bbih.2020.100043_bib71","doi-asserted-by":"crossref","first-page":"3599","DOI":"10.1002\/cne.22735","article-title":"The vertebrate mesolimbic reward system and social behavior network: a comparative synthesis","volume":"519","author":"O\u2019Connell","year":"2011","journal-title":"J.\u00a0Comp. Neurol."},{"issue":"4","key":"10.1016\/j.bbih.2020.100043_bib72","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.bbi.2012.01.015","article-title":"Maternal immune activation by LPS selectively alters specific gene expression profiles of interneuron migration and oxidative stress in the fetus without triggering a fetal immune response","volume":"26","author":"Oskvig","year":"2012","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.bbih.2020.100043_bib73","doi-asserted-by":"crossref","first-page":"546","DOI":"10.1016\/j.biopsych.2005.07.031","article-title":"Immune activation during pregnancy in mice leads to dopaminergic hyperfunction and cognitive impairment in the offspring: a neurodevelopmental animal model of schizophrenia","volume":"59","author":"Ozawa","year":"2006","journal-title":"Biol. Psychiatr."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib74","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1186\/s12974-017-0981-8","article-title":"Acute in utero exposure to lipopolysaccharide induces inflammation in the pre-and postnatal brain and alters the glial cytoarchitecture in the developing amygdala","volume":"14","author":"O\u2019Loughlin","year":"2017","journal-title":"J.\u00a0Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib75","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.ajp.2012.08.010","article-title":"BDNF\u2013TrkB signaling and neuroprotection in schizophrenia","volume":"6","author":"Pandya","year":"2013","journal-title":"Asian J. Psychiatr."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib76","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1159\/000319828","article-title":"Maternal immune activation and autism spectrum disorder: interleukin-6 signaling as a key mechanistic pathway","volume":"18","author":"Parker-Athill","year":"2010","journal-title":"Neurosignals"},{"key":"10.1016\/j.bbih.2020.100043_bib77","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.physbeh.2017.01.045","article-title":"Alteration of neurotrophin and cytokine expression in lymphocytes as novel peripheral markers of spatial memory deficits induced by prenatal stress","volume":"173","author":"Pascuan","year":"2017","journal-title":"Physiol. Behav."},{"issue":"7","key":"10.1016\/j.bbih.2020.100043_bib78","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1016\/j.molmed.2011.03.001","article-title":"Maternal infection and immune involvement in autism","volume":"17","author":"Patterson","year":"2011","journal-title":"Trends Mol. Med."},{"issue":"7","key":"10.1016\/j.bbih.2020.100043_bib79","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1038\/npp.2017.7","article-title":"Maternal immune activation causes behavioral impairments and altered cerebellar cytokine and synaptic protein expression","volume":"42","author":"Pendyala","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib80","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/S0306-4522(99)00316-4","article-title":"Changes in brain nerve growth factor levels and nerve growth factor receptors in rats exposed to environmental enrichment for one year","volume":"94","author":"Pham","year":"1999","journal-title":"Neuroscience"},{"issue":"9","key":"10.1016\/j.bbih.2020.100043_bib81","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/j.biopsych.2011.06.007","article-title":"Abnormal trajectories of neurodevelopment and behavior following in utero insult in the rat","volume":"70","author":"Piontkewitz","year":"2011","journal-title":"Biol. Psychiatr."},{"issue":"4542","key":"10.1016\/j.bbih.2020.100043_bib82","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1126\/science.6121377","article-title":"Abnormal glutamate metabolism in an adult-onset degenerative neurological disorder","volume":"216","author":"Plaitakis","year":"1982","journal-title":"Science"},{"issue":"6","key":"10.1016\/j.bbih.2020.100043_bib83","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1023\/A:1013290826504","article-title":"The abnormal regulation of gene expression in autistic brain tissue","volume":"31","author":"Purcell","year":"2001","journal-title":"J.\u00a0Autism Dev. Disord."},{"issue":"31","key":"10.1016\/j.bbih.2020.100043_bib84","doi-asserted-by":"crossref","first-page":"5104","DOI":"10.2174\/1381612819666131216114240","article-title":"The novel object recognition test in rodents in relation to cognitive impairment in schizophrenia","volume":"20","author":"Rajagopal","year":"2014","journal-title":"Curr. Pharmaceut. Des."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib85","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1016\/j.yhbeh.2012.03.015","article-title":"Sex effects on neurodevelopmental outcomes of innate immune activation during prenatal and neonatal life","volume":"62","author":"Rana","year":"2012","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbih.2020.100043_bib86","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.pharmthera.2015.01.001","article-title":"The poly (I: C)-induced maternal immune activation model in preclinical neuropsychiatric drug discovery","volume":"149","author":"Reisinger","year":"2015","journal-title":"Pharmacol. Ther."},{"issue":"6","key":"10.1016\/j.bbih.2020.100043_bib87","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1172\/JCI117272","article-title":"Prenatal immune challenge alters the hypothalamic-pituitary-adrenocortical axis in adult rats","volume":"93","author":"Reul","year":"1994","journal-title":"J.\u00a0Clin. Invest."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib88","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/S0306-4530(99)00058-X","article-title":"Glucocorticoids and the regulation of memory consolidation","volume":"25","author":"Roozendaal","year":"2000","journal-title":"Psychoneuroendocrinology"},{"issue":"11","key":"10.1016\/j.bbih.2020.100043_bib89","doi-asserted-by":"crossref","first-page":"1516","DOI":"10.1177\/0269215517705181","article-title":"Embedding an enriched environment in an acute stroke unit increases activity in people with stroke: a controlled before\u2013after pilot study","volume":"31","author":"Rosbergen","year":"2017","journal-title":"Clin. Rehabil."},{"issue":"8","key":"10.1016\/j.bbih.2020.100043_bib90","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1016\/j.neuropsychologia.2010.03.018","article-title":"Spatial working memory deficits in GluA1 AMPA receptor subunit knockout mice reflect impaired short-term habituation: evidence for Wagner\u2019s dual-process memory model","volume":"48","author":"Sanderson","year":"2010","journal-title":"Neuropsychologia"},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib91","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1038\/nn1412","article-title":"Restoration of spatial working memory by genetic rescue of GluR-A\u2013deficient mice","volume":"8","author":"Schmitt","year":"2005","journal-title":"Nat. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib92","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1016\/S0091-3057(02)00790-6","article-title":"Dissociable effects of isolation rearing and environmental enrichment on exploration, spatial learning and HPA activity in adult rats","volume":"73","author":"Schrijver","year":"2002","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"2","key":"10.1016\/j.bbih.2020.100043_bib93","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1037\/0735-7036.107.2.216","article-title":"Communal reproductive success in rats (Rattus norvegicus): effects of group composition and prior social experience","volume":"107","author":"Schultz","year":"1993","journal-title":"J.\u00a0Comp. Psychol."},{"issue":"6\u20137","key":"10.1016\/j.bbih.2020.100043_bib94","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1016\/j.neuint.2007.03.012","article-title":"The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention","volume":"51","author":"Sheldon","year":"2007","journal-title":"Neurochem. Int."},{"issue":"40","key":"10.1016\/j.bbih.2020.100043_bib95","doi-asserted-by":"crossref","first-page":"10695","DOI":"10.1523\/JNEUROSCI.2178-07.2007","article-title":"Maternal immune activation alters fetal brain development through interleukin-6","volume":"27","author":"Smith","year":"2007","journal-title":"J.\u00a0Neurosci."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib96","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1093\/schbul\/sbn121","article-title":"Association between prenatal exposure to bacterial infection and risk of schizophrenia","volume":"35","author":"S\u00f8rensen","year":"2008","journal-title":"Schizophr. Bull."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib97","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.acthis.2003.11.003","article-title":"ACTH-producing cells of 21-day-old rat fetuses after maternal dexamethasone exposure","volume":"106","author":"Stojanoski","year":"2004","journal-title":"Acta Histochem."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib98","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00429-005-0057-x","article-title":"The pituitary-adrenal axis of fetal rats after maternal dexamethasone treatment","volume":"211","author":"Stojanoski","year":"2006","journal-title":"Anat. Embryol."},{"issue":"7","key":"10.1016\/j.bbih.2020.100043_bib99","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1002\/dev.21750","article-title":"Differences in the persistence of spatial memory deficits induced by a chronic stressor in adolescents compared to juveniles","volume":"60","author":"Stylianakis","year":"2018","journal-title":"Dev. Psychobiol."},{"key":"10.1016\/j.bbih.2020.100043_bib100","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/2042-6410-3-15","article-title":"Sexually dimorphic effects of a prenatal immune challenge on social play and vasopressin expression in juvenile rats","volume":"3","author":"Taylor","year":"2012","journal-title":"Biol. Sex Differ."},{"issue":"3","key":"10.1016\/j.bbih.2020.100043_bib101","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of enviromental enrichment","volume":"1","author":"Van Praag","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"issue":"5973","key":"10.1016\/j.bbih.2020.100043_bib102","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1126\/science.327.5973.1571","article-title":"Of mice and women: the bias in animal models","volume":"327","author":"Wald","year":"2010","journal-title":"Science"},{"issue":"4","key":"10.1016\/j.bbih.2020.100043_bib103","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1016\/S0031-9384(01)00543-1","article-title":"Environmental enrichment: effects on spatial memory and hippocampal CREB immunoreactivity","volume":"73","author":"Williams","year":"2001","journal-title":"Physiol. Behav."},{"issue":"17","key":"10.1016\/j.bbih.2020.100043_bib104","doi-asserted-by":"crossref","first-page":"4243","DOI":"10.1523\/JNEUROSCI.0480-05.2005","article-title":"Glutamate receptors in perirhinal cortex mediate encoding, retrieval, and consolidation of object recognition memory","volume":"25","author":"Winters","year":"2005","journal-title":"J.\u00a0Neurosci."},{"issue":"4","key":"10.1016\/j.bbih.2020.100043_bib105","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1037\/bne0000068","article-title":"Environmental enrichment as a therapy for autism: a clinical trial replication and extension","volume":"129","author":"Woo","year":"2015","journal-title":"Behav. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib106","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.bbr.2007.08.025","article-title":"Enriched environment prevents chronic stress-induced spatial learning and memory deficits","volume":"187","author":"Wright","year":"2008","journal-title":"Behav. Brain Res."},{"issue":"8","key":"10.1016\/j.bbih.2020.100043_bib107","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0104433","article-title":"Gender-dependent effects of maternal immune activation on the behavior of mouse offspring","volume":"9","author":"Xuan","year":"2014","journal-title":"PloS One"},{"issue":"9","key":"10.1016\/j.bbih.2020.100043_bib108","doi-asserted-by":"crossref","first-page":"2033","DOI":"10.1096\/fj.06-7856com","article-title":"D-cycloserine improves functional recovery and reinstates long-term potentiation (LTP) in a mouse model of closed head injury","volume":"21","author":"Yaka","year":"2007","journal-title":"Faseb. J."},{"issue":"1","key":"10.1016\/j.bbih.2020.100043_bib109","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1159\/000355466","article-title":"Maternal immune activation increases the corticosterone response to acute stress without affecting the hypothalamic monoamine content and sleep patterns in male mice offspring","volume":"21","author":"Zager","year":"2014","journal-title":"Neuroimmunomodulation"},{"issue":"10","key":"10.1016\/j.bbih.2020.100043_bib110","doi-asserted-by":"crossref","first-page":"1778","DOI":"10.1038\/sj.npp.1300248","article-title":"Immune activation during pregnancy in rats leads to a postpubertal emergence of disrupted latent inhibition, dopaminergic hyperfunction, and altered limbic morphology in the offspring: a novel neurodevelopmental model of schizophrenia","volume":"28","author":"Zuckerman","year":"2003","journal-title":"Neuropsychopharmacology"}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620300089?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620300089?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:20:36Z","timestamp":1762986036000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354620300089"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":108,"alternative-id":["S2666354620300089"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100043","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Therapeutic efficacy of environmental enrichment on behavioral, endocrine, and synaptic alterations in an animal model of maternal immune activation","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100043","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100043"}}