{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:34:07Z","timestamp":1762986847277,"version":"3.45.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,3,1]],"date-time":"2020-03-01T00:00:00Z","timestamp":1583020800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,2,10]],"date-time":"2020-02-10T00:00:00Z","timestamp":1581292800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1109283"],"award-info":[{"award-number":["APP1109283"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2020,3]]},"DOI":"10.1016\/j.bbih.2020.100048","type":"journal-article","created":{"date-parts":[[2020,2,12]],"date-time":"2020-02-12T20:20:56Z","timestamp":1581538856000},"page":"100048","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":8,"special_numbering":"C","title":["Investigating the gut-brain axis in a neurodevelopmental rodent model of schizophrenia"],"prefix":"10.1016","volume":"3","author":[{"given":"Max W.","family":"Katz-Barber","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon L.","family":"Hollins","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Annalisa","family":"Cuskelly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2096-3376","authenticated-orcid":false,"given":"Angeline J.W.","family":"Leong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ariel","family":"Dunn","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lauren","family":"Harms","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Deborah M.","family":"Hodgson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbih.2020.100048_bib1","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1016\/j.clinthera.2015.03.002","article-title":"Gut microbiota: the conductor in the orchestra of immune\u2013neuroendocrine communication","volume":"37","author":"Aidy","year":"2015","journal-title":"Clin. Therapeut."},{"issue":"6","key":"10.1016\/j.bbih.2020.100048_bib2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1002\/ajmg.b.32567","article-title":"Microbiome, inflammation, epigenetic alterations, and mental diseases","volume":"174","author":"Alam","year":"2017","journal-title":"Am. J. Med. Genet. Part B: Neuropsychiatric Genetics"},{"article-title":"Tha Laboratory Rat. Handbook of Experimental Animals","year":"2000","author":"Allmann-Iselin","key":"10.1016\/j.bbih.2020.100048_bib3"},{"key":"10.1016\/j.bbih.2020.100048_bib4","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1016\/j.physbeh.2018.04.033","article-title":"Measuring corticosterone concentrations over a physiological dynamic range in female rats","volume":"194","author":"Bekhbat","year":"2018","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbih.2020.100048_bib5","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbr.2016.03.003","article-title":"Brief anesthesia by isoflurane alters plasma corticosterone levels distinctly in male and female rats: implications for tissue collection methods","volume":"305","author":"Bekhbat","year":"2016","journal-title":"Behav. Brain Res."},{"issue":"12","key":"10.1016\/j.bbih.2020.100048_bib6","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1111\/j.1365-2982.2011.01796.x","article-title":"The anxiolytic effect of Bifidobacterium longum NCC3001 involves vagal pathways for gut-brain communication","volume":"23","author":"Bercik","year":"2011","journal-title":"Neuro Gastroenterol. Motil."},{"issue":"4","key":"10.1016\/j.bbih.2020.100048_bib7","doi-asserted-by":"crossref","first-page":"324","DOI":"10.1016\/j.biopsych.2013.09.037","article-title":"Autoimmunity, inflammation, and psychosis_ A search for peripheral markers","volume":"75","author":"Bergink","year":"2014","journal-title":"Biol. Psychiatr."},{"issue":"7","key":"10.1016\/j.bbih.2020.100048_bib8","doi-asserted-by":"crossref","first-page":"2107","DOI":"10.1111\/j.1572-0241.2001.03943.x","article-title":"The comorbid occurrence of other diagnoses in patients with ulcerative colitis and crohn\u2019s disease","volume":"96","author":"Cucino","year":"2001","journal-title":"Am. J. Gastroenterol."},{"year":"2018","series-title":"The Neuroendocrinology of the Microbiota-Gut-Brain Axis: A Behavioural Perspective. Frontiers in Neuroendocrinology","author":"Cussotto","key":"10.1016\/j.bbih.2020.100048_bib9"},{"issue":"4","key":"10.1016\/j.bbih.2020.100048_bib10","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1016\/j.jchemneu.2010.07.005","article-title":"Differential treatment regimen-related effects of cannabinoids on D1 and D2 receptors in adolescent and adult rat brain","volume":"40","author":"Dalton","year":"2010","journal-title":"J.\u00a0Chem. Neuroanat."},{"issue":"1","key":"10.1016\/j.bbih.2020.100048_bib11","first-page":"1","article-title":"Synergistic effect between maternal infection and adolescent cannabinoid exposure on serotonin 5HT 1AReceptor binding in the Hippocampus: testing the \u201ctwo hit\u201d","volume":"2012","author":"Dalton","year":"2012","journal-title":"Hypothesis Dev. Schizophrenia"},{"issue":"6","key":"10.1016\/j.bbih.2020.100048_bib12","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.micres.2006.09.004","article-title":"Quantification of Bifidobacterium spp. and Lactobacillus spp. in rat fecal samples by real-time PCR","volume":"163","author":"Delroisse","year":"2008","journal-title":"Microbiol. Res."},{"key":"10.1016\/j.bbih.2020.100048_bib13","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1016\/j.semcdb.2017.09.010","article-title":"Perinatal inflammation and adult psychopathology: from preclinical models to humans","volume":"77","author":"Depino","year":"2018","journal-title":"Semin. Cell Dev. Biol."},{"key":"10.1016\/j.bbih.2020.100048_bib14","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.bbi.2016.12.010","article-title":"The microbiome, immunity, and schizophrenia and bipolar disorder","volume":"62","author":"Dickerson","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"C","key":"10.1016\/j.bbih.2020.100048_bib15","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.pnpbp.2015.09.006","article-title":"Increased white matter neuron density in a rat model of maternal immune activation \u2014 implications for schizophrenia","volume":"65","author":"Duchatel","year":"2016","journal-title":"Prog. Neuropsycho Pharmacol. Biol. Psychiat."},{"key":"10.1016\/j.bbih.2020.100048_bib16","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neubiorev.2013.11.006","article-title":"Inflammation and the two-hit hypothesis of schizophrenia","volume":"38","author":"Feigenson","year":"2014","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbih.2020.100048_bib17","series-title":"Handbook of Neurochemistry and Molecular Neurobiology","first-page":"467","article-title":"Schizophrenia and immune responses","author":"Gaughran","year":"2008"},{"issue":"5778","key":"10.1016\/j.bbih.2020.100048_bib18","doi-asserted-by":"crossref","first-page":"1355","DOI":"10.1126\/science.1124234","article-title":"Metagenomic analysis of the human distal gut microbiome","volume":"312","author":"Gill","year":"2006","journal-title":"Science"},{"key":"10.1016\/j.bbih.2020.100048_bib19","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0920-9964(96)00099-0","article-title":"The relationship between schizophrenia and irritable bowel syndrome (IBS)","volume":"23","author":"Gupta","year":"1997","journal-title":"Schizophr. Res."},{"issue":"4","key":"10.1016\/j.bbih.2020.100048_bib20","doi-asserted-by":"crossref","first-page":"1767","DOI":"10.1016\/j.neuropharm.2011.11.022","article-title":"A\u00a0stereological comparison of GAD67 and reelin expression in the hippocampal stratum oriens of offspring from two mouse models of maternal inflammation during pregnancy","volume":"62","author":"Harvey","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbih.2020.100048_bib21","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.pneurobio.2016.06.005","article-title":"MicroRNA: small RNA mediators of the brains genomic response to environmental stress","volume":"143","author":"Hollins","year":"2016","journal-title":"Prog. Neurobiol."},{"key":"10.1016\/j.bbih.2020.100048_bib22","series-title":"Advances in Psychobiology","first-page":"1","article-title":"The gut-brain Axis in neuropsychopathology","author":"Hollins","year":"2018"},{"key":"10.1016\/j.bbih.2020.100048_bib23","series-title":"Small RNA Regulation of Neural Gene Expression in Response to Environmental Exposure Associated with Neuropsychiatric Syndromes","first-page":"1","author":"Hollins","year":"2016"},{"issue":"9","key":"10.1016\/j.bbih.2020.100048_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/tp.2014.99","article-title":"Alteration of imprinted Dlk1-Dio3 miRNA cluster expression in the entorhinal cortex induced by maternal immune activation and adolescent cannabinoid exposure","volume":"4","author":"Hollins","year":"2014","journal-title":"Transl. Psychiatry"},{"issue":"C","key":"10.1016\/j.bbih.2020.100048_bib25","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbi.2016.02.021","article-title":"Alteration of transcriptional networks in the entorhinal cortex after maternal immune activation and adolescent cannabinoid exposure","volume":"56","author":"Hollins","year":"2016","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.bbih.2020.100048_bib26","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1073\/pnas.1114122109","article-title":"BDNF and glucocorticoids regulate corticotrophin- releasing hormone (CRH) homeostasis in the hypothalamus","volume":"109","author":"Jeanneteau","year":"2012","journal-title":"Pnas"},{"issue":"1","key":"10.1016\/j.bbih.2020.100048_bib27","first-page":"1","article-title":"Suppression of gut dysbiosis by Bifidobacterium longum alleviates cognitive decline in 5XFAD transgenic and aged mice","volume":"9","author":"Lee","year":"2019","journal-title":"Sci. Rep."},{"issue":"1","key":"10.1016\/j.bbih.2020.100048_bib28","doi-asserted-by":"crossref","first-page":"11","DOI":"10.5217\/ir.2015.13.1.11","article-title":"Intestinal permeability regulation by tight junction: implication on inflammatory bowel diseases","volume":"13","author":"Lee","year":"2015","journal-title":"Intest. Res."},{"author":"Livak","key":"10.1016\/j.bbih.2020.100048_bib29"},{"issue":"5","key":"10.1016\/j.bbih.2020.100048_bib30","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1023\/A:1013863205647","article-title":"Regulation of corticotropin-releasing hormone (CRH) transcription and CRH mRNA stability by glucocorticoids","volume":"21","author":"Ma","year":"2001","journal-title":"Cell. Mol. Neurobiol."},{"issue":"2","key":"10.1016\/j.bbih.2020.100048_bib31","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1093\/schbul\/20.2.263","article-title":"Prenatal influenza infections and adult schizophrenia","volume":"20","author":"Mednick","year":"1994","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbih.2020.100048_bib32","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1016\/j.bbi.2016.07.144","article-title":"Effects of immune activation during early or late gestation on schizophrenia-related behaviour in adult rat offspring","volume":"63","author":"Meehan","year":"2017","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.bbih.2020.100048_bib33","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1017\/S0007114510004319","article-title":"Assessment of psychotropic-like properties of a probiotic formulation ( Lactobacillus helveticus R0052 and Bifidobacterium longum R0175) in rats and human subjects","volume":"105","author":"Messaoudi","year":"2010","journal-title":"Br. J. Nutr."},{"issue":"3","key":"10.1016\/j.bbih.2020.100048_bib34","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1080\/07315724.2018.1487346","article-title":"The effects of probiotic formulation pretreatment (lactobacillus helveticus R0052 and bifidobacterium longum R0175) on a lipopolysaccharide rat model","volume":"38","author":"Mohammadi","year":"2019","journal-title":"J.\u00a0Am. Coll. Nutr."},{"issue":"9584","key":"10.1016\/j.bbih.2020.100048_bib35","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1016\/S0140-6736(07)61162-3","article-title":"Cannabis use and risk of psychotic or affective mental health outcomes: a systematic review","volume":"370","author":"Moore","year":"2007","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2020.100048_bib36","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.pnpbp.2014.08.018","article-title":"Schizophrenia and the gut\u2013brain axis","volume":"56","author":"Nemani","year":"2015","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"issue":"4","key":"10.1016\/j.bbih.2020.100048_bib37","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1093\/femsre\/fuu010","article-title":"Microbial endocrinology: the interplay between the microbiota and the endocrine system","volume":"39","author":"Neuman","year":"2015","journal-title":"FEMS Microbiol. Rev."},{"issue":"3","key":"10.1016\/j.bbih.2020.100048_bib38","doi-asserted-by":"crossref","first-page":"141","DOI":"10.12938\/bmfh.2016-004","article-title":"Effect of repeated oral administration of Bifidobacterium longum BB536 on apomorphine-induced rearing behavior in mice","volume":"35","author":"Orikasa","year":"2016","journal-title":"Biosci. Microbio. Food Health"},{"year":"1998","series-title":"The Rat Brain in Sterotaxic Coordinates","author":"Paxinos","key":"10.1016\/j.bbih.2020.100048_bib39"},{"key":"10.1016\/j.bbih.2020.100048_bib40","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2017.00077","article-title":"Effects of immune activation during early or late gestation on N-Methyl-d-Aspartate receptor measures in adult rat offspring","volume":"8","author":"Rahman","year":"2017","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.bbih.2020.100048_bib41","first-page":"624","article-title":"The laboratory rat- relating its age with Human\u2019s.pdf","author":"Sengupta","year":"2013","journal-title":"Int. J. Prevent. Med."},{"issue":"3","key":"10.1016\/j.bbih.2020.100048_bib42","doi-asserted-by":"crossref","first-page":"e57700","DOI":"10.1371\/journal.pone.0057700","article-title":"Functional programming of the autonomic nervous system by early life immune exposure: implications for anxiety","volume":"8","author":"Sominsky","year":"2013","journal-title":"PloS One"},{"key":"10.1016\/j.bbih.2020.100048_bib43","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"C","key":"10.1016\/j.bbih.2020.100048_bib44","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.cellimm.2016.03.007","article-title":"Droplet digital PCR quantifies host inflammatory transcripts in feces reliably and reproducibly","volume":"303","author":"Stauber","year":"2016","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.bbih.2020.100048_bib45","first-page":"3","article-title":"Effects of prenatal stress on developmental anatomy of the brain and adult behavioural pathology","volume":"3","author":"Ulup\u0131nar","year":"2009","journal-title":"Anatomy. Int. J. Exp. Clin. Anat."},{"issue":"4","key":"10.1016\/j.bbih.2020.100048_bib46","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1176\/ajp.156.4.617","article-title":"Minor physical anomalies, dermatoglyphic asymmetries, and cortisol levels in adolescents with schizotypal personality disorder","volume":"156","author":"Weinstein","year":"1999","journal-title":"Am. J. Psychiatr."},{"issue":"2","key":"10.1016\/j.bbih.2020.100048_bib47","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau8317","article-title":"The gut microbiome from patients with schizophrenia modulates the glutamate-glutamine-GABA cycle and schizophrenia-relevant behaviors in mice","volume":"5","author":"Zheng","year":"2019","journal-title":"Sci. Adv."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620300132?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620300132?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:20:14Z","timestamp":1762986014000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354620300132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,3]]},"references-count":47,"alternative-id":["S2666354620300132"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100048","relation":{},"ISSN":["2666-3546"],"issn-type":[{"type":"print","value":"2666-3546"}],"subject":[],"published":{"date-parts":[[2020,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Investigating the gut-brain axis in a neurodevelopmental rodent model of schizophrenia","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100048","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100048"}}