{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T13:37:29Z","timestamp":1787319449371,"version":"build-2736575974"},"reference-count":102,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,10,1]],"date-time":"2020-10-01T00:00:00Z","timestamp":1601510400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,8,9]],"date-time":"2020-08-09T00:00:00Z","timestamp":1596931200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001459","name":"Ministry of Education - Singapore","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001459","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100004412","name":"Human Frontier Science Program","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100004412","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2020,10]]},"DOI":"10.1016\/j.bbih.2020.100128","type":"journal-article","created":{"date-parts":[[2020,8,11]],"date-time":"2020-08-11T12:41:05Z","timestamp":1597149665000},"page":"100128","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Urolithin-A attenuates neurotoxoplasmosis and alters innate response towards predator odor"],"prefix":"10.1016","volume":"8","author":[{"given":"Sijie","family":"Tan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen Han","family":"Tong","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2592-6796","authenticated-orcid":false,"given":"Ajai","family":"Vyas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib1","first-page":"369","article-title":"Focus: Organelles: in vitro screening to identify anti-toxoplasma compounds and in silico modeling for bioactivities and toxicity","volume":"92","author":"Adeyemi","year":"2019","journal-title":"Yale J. Biol. Med."},{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib2","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2020.e03495","article-title":"Altered redox status, DNA damage and modulation of L-tryptophan metabolism contribute to antimicrobial action of curcumin","volume":"6","author":"Adeyemi","year":"2020","journal-title":"Heliyon"},{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032489","article-title":"Chronic Toxoplasma infection modifies the structure and the risk of host behavior","volume":"7","author":"Afonso","year":"2012","journal-title":"PloS One"},{"issue":"9","key":"10.1016\/j.bbih.2020.100128_bib4","doi-asserted-by":"crossref","first-page":"976","DOI":"10.1111\/cns.13136","article-title":"Urolithin A-activated autophagy but not mitophagy protects against ischemic neuronal injury by inhibiting ER stress in vitro and in vivo","volume":"25","author":"Ahsan","year":"2019","journal-title":"CNS Neurosci. Ther."},{"issue":"8","key":"10.1016\/j.bbih.2020.100128_bib5","doi-asserted-by":"crossref","first-page":"730","DOI":"10.1016\/j.apjtm.2016.06.012","article-title":"Toxoplasmosis and anti-Toxoplasma effects of medicinal plant extracts-A mini-review","volume":"9","author":"Al Nasr","year":"2016","journal-title":"Asian Pac. J. Trop. Med."},{"key":"10.1016\/j.bbih.2020.100128_bib6","doi-asserted-by":"crossref","first-page":"273","DOI":"10.2147\/DDDT.S60973","article-title":"Drugs in development for toxoplasmosis: advances, challenges, and current status","volume":"11","author":"Alday","year":"2017","journal-title":"Drug Des. Dev. Ther."},{"issue":"2","key":"10.1016\/j.bbih.2020.100128_bib7","doi-asserted-by":"crossref","DOI":"10.1128\/AAC.01866-16","article-title":"Genetic evidence for cytochrome b Qi site inhibition by 4 (1H)-quinolone-3-diarylethers and antimycin in Toxoplasma gondii","volume":"61","author":"Alday","year":"2017","journal-title":"Antimicrob. Agents Chemother."},{"issue":"6","key":"10.1016\/j.bbih.2020.100128_bib8","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1038\/s42255-019-0073-4","article-title":"The mitophagy activator urolithin A is safe and induces a molecular signature of improved mitochondrial and cellular health in humans","volume":"1","author":"Andreux","year":"2019","journal-title":"Nat. Metabol."},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib9","first-page":"43","article-title":"Anti-toxoplasmosis activity of herbal medicines: narrative review","volume":"2","author":"Arab-Mazar","year":"2017","journal-title":"Herb. Med. J."},{"key":"10.1016\/j.bbih.2020.100128_bib10","doi-asserted-by":"crossref","first-page":"7363","DOI":"10.2147\/IJN.S181896","article-title":"Curcumin nanoemulsion as a novel chemical for the treatment of acute and chronic toxoplasmosis in mice","volume":"13","author":"Azami","year":"2018","journal-title":"Int. J. Nanomed."},{"issue":"1452","key":"10.1016\/j.bbih.2020.100128_bib11","doi-asserted-by":"crossref","first-page":"1591","DOI":"10.1098\/rspb.2000.1182","article-title":"Fatal attraction in rats infected with Toxoplasma gondii","volume":"267","author":"Berdoy","year":"2000","journal-title":"Proc. Roy. Soc. Lond. B Biol. Sci."},{"key":"10.1016\/j.bbih.2020.100128_bib12","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1146\/annurev-micro-091014-104100","article-title":"Lytic cycle of Toxoplasma gondii: 15 years later","volume":"69","author":"Blader","year":"2015","journal-title":"Annu. Rev. Microbiol."},{"key":"10.1016\/j.bbih.2020.100128_bib13","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cois.2018.11.004","article-title":"Ontogenetic strategies in insect herbivores and their impact on tri-trophic interactions","volume":"32","author":"Boege","year":"2019","journal-title":"Curr. Opin. Insect Sci."},{"issue":"2","key":"10.1016\/j.bbih.2020.100128_bib14","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1016\/j.celrep.2019.12.019","article-title":"Neuroinflammation-associated aspecific manipulation of mouse predator fear by toxoplasma gondii","volume":"30","author":"Boillat","year":"2020","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbih.2020.100128_bib15","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1016\/j.micpath.2015.01.001","article-title":"Sulfamethoxazole-trimethoprim associated with resveratrol for the treatment of toxoplasmosis in mice: influence on the activity of enzymes involved in brain neurotransmission","volume":"79","author":"Bottari","year":"2015","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bbih.2020.100128_bib16","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.micpath.2015.07.013","article-title":"Effects of sulfamethoxazole-trimethoprim associated to resveratrol on its free form and complexed with 2-hydroxypropyl-\u03b2-cyclodextrin on cytokines levels of mice infected by Toxoplasma gondii","volume":"87","author":"Bottari","year":"2015","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bbih.2020.100128_bib17","doi-asserted-by":"crossref","first-page":"166","DOI":"10.1016\/j.micpath.2016.04.002","article-title":"Synergistic effects of resveratrol (free and inclusion complex) and sulfamethoxazole-trimetropim treatment on pathology, oxidant\/antioxidant status and behavior of mice infected with Toxoplasma gondii","volume":"95","author":"Bottari","year":"2016","journal-title":"Microb. Pathog."},{"issue":"2","key":"10.1016\/j.bbih.2020.100128_bib18","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1005447","article-title":"Neurons are the primary target cell for the brain-tropic intracellular parasite Toxoplasma gondii","volume":"12","author":"Cabral","year":"2016","journal-title":"PLoS Pathog."},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib19","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1007\/s00394-003-0396-4","article-title":"Evaluation of the bioavailability and metabolism in the rat of punicalagin, an antioxidant polyphenol from pomegranate juice","volume":"42","author":"Cerd\u00e1","year":"2003","journal-title":"Eur. J. Nutr."},{"issue":"4","key":"10.1016\/j.bbih.2020.100128_bib20","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1007\/s00394-004-0461-7","article-title":"The potent in vitro antioxidant ellagitannins from pomegranate juice are metabolised into bioavailable but poor antioxidant hydroxy-6H-dibenzopyran-6-one derivatives by the colonic microflora of healthy humans","volume":"43","author":"Cerd\u00e1","year":"2004","journal-title":"Eur. J. Nutr."},{"key":"10.1016\/j.bbih.2020.100128_bib21","first-page":"1","article-title":"Activation of the miR-34a-mediated SIRT1\/mTOR signaling pathway by urolithin A attenuates d-galactose-induced brain aging in mice","author":"Chen","year":"2019","journal-title":"Neurotherapeutics"},{"issue":"7526","key":"10.1016\/j.bbih.2020.100128_bib22","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1038\/nature13800","article-title":"A\u00a0three-dimensional human neural cell culture model of Alzheimer\u2019s disease","volume":"515","author":"Choi","year":"2014","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib23","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1007\/s00436-010-1832-z","article-title":"The effect of essential oils from Thymus broussonetii Boiss on transmission of Toxoplasma gondii cysts in mice","volume":"107","author":"Dahbi","year":"2010","journal-title":"Parasitol. Res."},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib24","doi-asserted-by":"crossref","first-page":"33","DOI":"10.7326\/0003-4819-116-1-33","article-title":"Treatment of toxoplasmic encephalitis in patients with AIDS: a randomized trial comparing pyrimethamine plus clindamycin to pyrimethamine plus sulfadiazine","volume":"116","author":"Dannemann","year":"1992","journal-title":"Ann. Intern. Med."},{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib25","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/1028415X.2017.1360558","article-title":"Pomegranate ellagitannin-gut microbial-derived metabolites, urolithins, inhibit neuroinflammation in vitro","volume":"22","author":"DaSilva","year":"2019","journal-title":"Nutr. Neurosci."},{"issue":"5","key":"10.1016\/j.bbih.2020.100128_bib26","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1021\/np900749b","article-title":"Action of a pentacyclic triterpenoid, maslinic acid, against Toxoplasma gondii","volume":"73","author":"De Pablos","year":"2010","journal-title":"J.\u00a0Nat. Prod."},{"key":"10.1016\/j.bbih.2020.100128_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejmech.2019.111711","article-title":"Recent progress on anti-Toxoplasma drugs discovery: design, synthesis and screening","author":"Deng","year":"2019","journal-title":"Eur. J. Med. Chem."},{"key":"10.1016\/j.bbih.2020.100128_bib28","doi-asserted-by":"crossref","first-page":"103467","DOI":"10.1016\/j.bioorg.2019.103467","article-title":"Synthesis, in vitro and in vivo biological evaluation of dihydroartemisinin derivatives with potential anti-Toxoplasma gondii agents","volume":"94","author":"Deng","year":"2020","journal-title":"Bioorg. Chem."},{"issue":"39","key":"10.1016\/j.bbih.2020.100128_bib29","doi-asserted-by":"crossref","first-page":"15936","DOI":"10.1073\/pnas.1208069109","article-title":"Endochin-like quinolones are highly efficacious against acute and latent experimental toxoplasmosis","volume":"109","author":"Doggett","year":"2012","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib30","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2202-8-36","article-title":"Differential development of neuronal physiological responsiveness in two human neural stem cell lines","volume":"8","author":"Donato","year":"2007","journal-title":"BMC Neurosci."},{"key":"10.1016\/j.bbih.2020.100128_bib31","series-title":"Toxoplasmosis of Animals and Humans","author":"Dubey","year":"2016"},{"key":"10.1016\/j.bbih.2020.100128_bib32","series-title":"Toxoplasma Gondii","first-page":"1","article-title":"The history and life cycle of Toxoplasma gondii","author":"Dubey","year":"2020"},{"issue":"2","key":"10.1016\/j.bbih.2020.100128_bib33","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1128\/CMR.11.2.267","article-title":"Structures of Toxoplasma gondiitachyzoites, bradyzoites, and sporozoites and biology and development of tissue cysts","volume":"11","author":"Dubey","year":"1998","journal-title":"Clin. Microbiol. Rev."},{"issue":"4","key":"10.1016\/j.bbih.2020.100128_bib34","doi-asserted-by":"crossref","DOI":"10.1128\/CMR.00057-17","article-title":"Treatment of toxoplasmosis: historical perspective, animal models, and current clinical practice","volume":"31","author":"Dunay","year":"2018","journal-title":"Clin. Microbiol. Rev."},{"issue":"7","key":"10.1016\/j.bbih.2020.100128_bib35","doi-asserted-by":"crossref","first-page":"2863","DOI":"10.1007\/s00436-016-5041-2","article-title":"Effects of Thymus vulgaris ethanolic extract on chronic toxoplasmosis in a mouse model","volume":"115","author":"Eraky","year":"2016","journal-title":"Parasitol. Res."},{"key":"10.1016\/j.bbih.2020.100128_bib36","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/270418","article-title":"Biological significance of urolithins, the gut microbial ellagic Acid-derived metabolites: the evidence so far","volume":"2013","author":"Espin","year":"2013","journal-title":"Evid. Based Complement Alternat. Med."},{"key":"10.1016\/j.bbih.2020.100128_bib37","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1016\/j.bbi.2013.11.012","article-title":"Patterns of Toxoplasma gondii cyst distribution in the forebrain associate with individual variation in predator odor avoidance and anxiety-related behavior in male Long\u2013Evans rats","volume":"37","author":"Evans","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2020.100128_bib38","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.jns.2015.02.028","article-title":"Neurobiological studies on the relationship between toxoplasmosis and neuropsychiatric diseases","volume":"351","author":"Fabiani","year":"2015","journal-title":"J.\u00a0Neurol. Sci."},{"issue":"5","key":"10.1016\/j.bbih.2020.100128_bib39","doi-asserted-by":"crossref","first-page":"668","DOI":"10.1039\/C5NP00127G","article-title":"Strategies for target identification of antimicrobial natural products","volume":"33","author":"Farha","year":"2016","journal-title":"Nat. Prod. Rep."},{"issue":"6","key":"10.1016\/j.bbih.2020.100128_bib40","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1007\/BF00535321","article-title":"An ultrastructural study of the early development and tissue cyst formation of Toxoplasma gondii in the brains of mice","volume":"73","author":"Ferguson","year":"1987","journal-title":"Parasitol. Res."},{"issue":"8","key":"10.1016\/j.bbih.2020.100128_bib41","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1007\/BF00930955","article-title":"Tissue cyst rupture in mice chronically infected with Toxoplasma gondii","volume":"75","author":"Ferguson","year":"1989","journal-title":"Parasitol. Res."},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-11512-6","article-title":"Polyphenols journey through blood-brain barrier towards neuronal protection","volume":"7","author":"Figueira","year":"2017","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib43","doi-asserted-by":"crossref","first-page":"517","DOI":"10.4269\/ajtmh.1987.36.517","article-title":"Cyst rupture as a pathogenic mechanism of toxoplasmic encephalitis","volume":"36","author":"Frenkel","year":"1987","journal-title":"Am. J. Trop. Med. Hyg."},{"issue":"3919","key":"10.1016\/j.bbih.2020.100128_bib44","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1126\/science.167.3919.893","article-title":"Toxoplasma gondii in cats: fecal stages identified as coccidian oocysts","volume":"167","author":"Frenkel","year":"1970","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib45","doi-asserted-by":"crossref","first-page":"281","DOI":"10.4103\/0974-777X.83536","article-title":"Toxoplasmosis: a global threat","volume":"3","author":"Furtado","year":"2011","journal-title":"J.\u00a0Global Infect. Dis."},{"issue":"8","key":"10.1016\/j.bbih.2020.100128_bib46","doi-asserted-by":"crossref","first-page":"1341","DOI":"10.1021\/acschemneuro.5b00051","article-title":"Fate of microbial metabolites of dietary polyphenols in rats: is the brain their target destination?","volume":"6","author":"Gasperotti","year":"2015","journal-title":"ACS Chem. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib47","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s12974-019-1450-3","article-title":"Urolithin A attenuates memory impairment and neuroinflammation in APP\/PS1 mice","volume":"16","author":"Gong","year":"2019","journal-title":"J.\u00a0Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib48","doi-asserted-by":"crossref","first-page":"654","DOI":"10.1186\/s13071-015-1268-5","article-title":"Characterization of Toxoplasma gondii glyoxalase 1 and evaluation of inhibitory effects of curcumin on the enzyme and parasite cultures","volume":"8","author":"Goo","year":"2015","journal-title":"Parasites Vectors"},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib49","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1128\/AAC.03663-14","article-title":"Antimalarial action of artesunate involves DNA damage mediated by reactive oxygen species","volume":"59","author":"Gopalakrishnan","year":"2015","journal-title":"Antimicrob. Agents Chemother."},{"issue":"2","key":"10.1016\/j.bbih.2020.100128_bib50","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4315\/0362-028X.JFP-14-328","article-title":"Prevalence and risk factors for Toxoplasma gondii infection in meat animals and meat products destined for human consumption","volume":"78","author":"Guo","year":"2015","journal-title":"J.\u00a0Food Protect."},{"key":"10.1016\/j.bbih.2020.100128_bib51","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/j.foodcont.2014.05.047","article-title":"Natural products as antimicrobial agents","volume":"46","author":"Gyawali","year":"2014","journal-title":"Food Contr."},{"issue":"6","key":"10.1016\/j.bbih.2020.100128_bib53","doi-asserted-by":"crossref","first-page":"1833","DOI":"10.1002\/pmic.200500556","article-title":"2-DE proteome analysis of a proliferating and differentiating human neuronal stem cell line (ReNcell VM)","volume":"6","author":"Hoffrogge","year":"2006","journal-title":"Proteomics"},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-017-01525-6","article-title":"Rottler in-mediated inhibition of Toxoplasma gondii growth in BeWo trophoblast-like cells","volume":"7","author":"Ietta","year":"2017","journal-title":"Sci. Rep."},{"issue":"13","key":"10.1016\/j.bbih.2020.100128_bib55","doi-asserted-by":"crossref","first-page":"2355","DOI":"10.1007\/s00018-018-2808-x","article-title":"A\u00a0latent ability to persist: differentiation in Toxoplasma gondii","volume":"75","author":"Jeffers","year":"2018","journal-title":"Cell. Mol. Life Sci."},{"key":"10.1016\/j.bbih.2020.100128_bib56","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1146\/annurev-food-030810-153709","article-title":"Pomegranate as a functional food and nutraceutical source","volume":"2","author":"Johanningsmeier","year":"2011","journal-title":"Annu. Rev. Food Sci. Technol."},{"issue":"2","key":"10.1016\/j.bbih.2020.100128_bib57","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1093\/clinids\/22.2.268","article-title":"Pyrimethamine-clindamycin vs. pyrimethamine-sulfadiazine as acute and long-term therapy for toxoplasmic encephalitis in patients with AIDS","volume":"22","author":"Katlama","year":"1996","journal-title":"Clin. Infect. Dis."},{"issue":"12","key":"10.1016\/j.bbih.2020.100128_bib58","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1016\/j.ijpara.2008.06.002","article-title":"Control of the risk of human toxoplasmosis transmitted by meat","volume":"38","author":"Kijlstra","year":"2008","journal-title":"Int. J. Parasitol."},{"issue":"4","key":"10.1016\/j.bbih.2020.100128_bib59","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nmeth.1438","article-title":"Toxoplasma secreting Cre recombinase for analysis of host-parasite interactions","volume":"7","author":"Koshy","year":"2010","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbih.2020.100128_bib60","series-title":"Toxoplasma Gondii","first-page":"1043","article-title":"Cerebral toxoplasmosis","author":"Koshy","year":"2020"},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib61","doi-asserted-by":"crossref","first-page":"202","DOI":"10.3390\/ijms21010202","article-title":"Neuroprotective effects of pomegranate juice against Parkinson\u2019s disease and presence of ellagitannins-derived metabolite\u2014urolithin A\u2014in the brain","volume":"21","author":"Kujawska","year":"2020","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbih.2020.100128_bib62","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.phymed.2018.06.032","article-title":"Anti-inflammatory and antioxidant mechanisms of urolithin B in activated microglia","volume":"55","author":"Lee","year":"2019","journal-title":"Phytomedicine"},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib63","doi-asserted-by":"crossref","first-page":"7","DOI":"10.3347\/kjp.2020.58.1.7","article-title":"4-Hydroxybenzaldehyde restricts the intracellular growth of toxoplasma gondii by inducing SIRT1-mediated autophagy in macrophages","volume":"58","author":"Lee","year":"2020","journal-title":"Kor. J. Parasitol."},{"issue":"5","key":"10.1016\/j.bbih.2020.100128_bib64","first-page":"766","article-title":"Metacytofil in is a potent therapeutic drug candidate for toxoplasmosis","volume":"221","author":"Leesombun","year":"2020","journal-title":"J.\u00a0Infect. Dis."},{"issue":"5","key":"10.1016\/j.bbih.2020.100128_bib65","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1017\/S0031182015001985","article-title":"Induction of autophagy interferes the tachyzoite to bradyzoite transformation of Toxoplasma gondii","volume":"143","author":"Li","year":"2016","journal-title":"Parasitology"},{"key":"10.1016\/j.bbih.2020.100128_bib66","series-title":"Toxoplasma Gondii","first-page":"293","article-title":"Toxoplasmosis in wild and domestic animals","author":"Lindsay","year":"2020"},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib67","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1080\/14756366.2019.1584622","article-title":"Synthesis and biological evaluation of ursolic acid derivatives bearing triazole moieties as potential anti-Toxoplasma gondii agents","volume":"34","author":"Luan","year":"2019","journal-title":"J.\u00a0Enzym. Inhib. Med. Chem."},{"issue":"21","key":"10.1016\/j.bbih.2020.100128_bib68","doi-asserted-by":"crossref","first-page":"2318","DOI":"10.1016\/j.phytochem.2006.08.006","article-title":"Polyphenol oxidases in plants and fungi: going places?","volume":"67","author":"Mayer","year":"2006","journal-title":"Rev. Phytochem."},{"key":"10.1016\/j.bbih.2020.100128_bib69","series-title":"Drug\u2019s 5000% Price Rise Puts Spotlight on Soaring US Drug Costs","author":"McCarthy","year":"2015"},{"issue":"11","key":"10.1016\/j.bbih.2020.100128_bib70","doi-asserted-by":"crossref","first-page":"1574","DOI":"10.1021\/acsinfecdis.8b00133","volume":"4","author":"McConnell","year":"2018","journal-title":"ACS Infect. Dis."},{"key":"10.1016\/j.bbih.2020.100128_bib71","series-title":"Toxoplasma Gondii","first-page":"117","article-title":"Human toxoplasma infection","author":"McLeod","year":"2020"},{"key":"10.1016\/j.bbih.2020.100128_bib72","article-title":"Host cell preference of Toxoplasma gondii cysts in murine brain: a confocal study","volume":"1","author":"Melzer","year":"2010","journal-title":"J.\u00a0Neuroparasitol."},{"issue":"23","key":"10.1016\/j.bbih.2020.100128_bib73","doi-asserted-by":"crossref","first-page":"8956","DOI":"10.1021\/jf061674h","article-title":"Absorption, metabolism, and antioxidant effects of pomegranate (punica granatum L.) polyphenols after ingestion of a standardized extract in healthy human volunteers","volume":"54","author":"Mertens-Talcott","year":"2006","journal-title":"J.\u00a0Agric. Food Chem."},{"key":"10.1016\/j.bbih.2020.100128_bib74","doi-asserted-by":"crossref","first-page":"928","DOI":"10.2307\/3286588","article-title":"Oral infections with Toxoplasma cysts and oocysts in felines, other mammals, and in birds","author":"Miller","year":"1972","journal-title":"J.\u00a0Parasitol."},{"issue":"4","key":"10.1016\/j.bbih.2020.100128_bib75","first-page":"898","article-title":"Global status of Toxoplasma gondii infection: systematic review and prevalence snapshots","volume":"36","author":"Molan","year":"2019","journal-title":"Trop. Biomed."},{"issue":"11","key":"10.1016\/j.bbih.2020.100128_bib76","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.1128\/EC.00262-07","article-title":"Artemisinin induces calcium-dependent protein secretion in the protozoan parasite Toxoplasma gondii","volume":"6","author":"Nagamune","year":"2007","journal-title":"Eukaryot. Cell"},{"issue":"4","key":"10.1016\/j.bbih.2020.100128_bib77","doi-asserted-by":"crossref","first-page":"160","DOI":"10.7883\/yoken.JJID.2004.160","article-title":"Toxoplasmosis in HIV\/AIDS patients: a current situation","volume":"57","author":"Nissapatorn","year":"2004","journal-title":"Jpn. J. Infect. Dis."},{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib78","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1111\/pim.12157","article-title":"Toxoplasma gondii-induced neuronal alterations","volume":"37","author":"Parlog","year":"2015","journal-title":"Parasite Immunol."},{"issue":"23","key":"10.1016\/j.bbih.2020.100128_bib79","doi-asserted-by":"crossref","first-page":"1643","DOI":"10.1056\/NEJM199212033272306","article-title":"Toxoplasmosis of the central nervous system in the acquired immunodeficiency syndrome","volume":"327","author":"Porter","year":"1992","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"24","key":"10.1016\/j.bbih.2020.100128_bib80","doi-asserted-by":"crossref","first-page":"1308","DOI":"10.1056\/NEJM196512092732404","article-title":"Isolation of the encysted form of Toxoplasma gondii from human skeletal muscle and brain","volume":"273","author":"Remington","year":"1965","journal-title":"N.\u00a0Engl. J. Med."},{"issue":"8","key":"10.1016\/j.bbih.2020.100128_bib81","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1038\/nm.4132","article-title":"Urolithin A induces mitophagy and prolongs lifespan in C. elegans and increases muscle function in rodents","volume":"22","author":"Ryu","year":"2016","journal-title":"Nat. Med."},{"issue":"4","key":"10.1016\/j.bbih.2020.100128_bib82","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1645\/13-451.1","article-title":"A\u00a0thiazole derivative of artemisinin moderately reduces Toxoplasma gondii cyst burden in infected mice","volume":"100","author":"Schultz","year":"2014","journal-title":"J.\u00a0Parasitol."},{"issue":"10","key":"10.1016\/j.bbih.2020.100128_bib83","doi-asserted-by":"crossref","first-page":"2481","DOI":"10.1093\/jn\/136.10.2481","article-title":"Pomegranate juice ellagitannin metabolites are present in human plasma and some persist in urine for up to 48 hours","volume":"136","author":"Seeram","year":"2006","journal-title":"J.\u00a0Nutr."},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib84","doi-asserted-by":"crossref","first-page":"9017","DOI":"10.1038\/s41598-019-45220-0","article-title":"Different phenotypic plastic responses to predators observed among aphid lineages specialized on different host plants","volume":"9","author":"Sentis","year":"2019","journal-title":"Sci. Rep."},{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib85","doi-asserted-by":"crossref","first-page":"186","DOI":"10.2174\/1574891X10666150410120321","article-title":"Anti-Toxoplasma activity of natural products: a review","volume":"9","author":"Sepulveda-Arias","year":"2014","journal-title":"Recent Pat. Anti-Infect. Drug Discov."},{"key":"10.1016\/j.bbih.2020.100128_bib86","series-title":"International Review of Neurobiology","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/bs.irn.2016.08.008","article-title":"Toxoplasma gondii\u2014a gastrointestinal pathogen associated with human brain diseases","author":"Severance","year":"2016"},{"issue":"2","key":"10.1016\/j.bbih.2020.100128_bib87","first-page":"238","article-title":"Licochalcone A: an effective and low-toxicity compound against Toxoplasma gondii in vitro and in vivo","volume":"8","author":"Si","year":"2018","journal-title":"Int. J. Parasitol.: Drugs Drug Resist."},{"key":"10.1016\/j.bbih.2020.100128_bib88","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1055\/a-1088-8449","article-title":"In vitro and in vivo activity of anogeissus leiocarpa bark extract and isolated metabolites against toxoplasma gondii","volume":"86","author":"Spalenka","year":"2020","journal-title":"Planta Med."},{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib89","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1111\/j.1574-6976.2011.00305.x","article-title":"Mechanisms of Toxoplasma gondii persistence and latency","volume":"36","author":"Sullivan","year":"2012","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.bbih.2020.100128_bib90","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.51029","article-title":"Tritrophic metabolism of plant chemical defenses and its effects on herbivore and predator performance","volume":"8","author":"Sun","year":"2019","journal-title":"Elife"},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib91","first-page":"1","article-title":"Pomegranate activates TFEB to promote autophagy-lysosomal fitness and mitophagy","volume":"9","author":"Tan","year":"2019","journal-title":"Sci. Rep."},{"issue":"13","key":"10.1016\/j.bbih.2020.100128_bib92","doi-asserted-by":"crossref","first-page":"2040","DOI":"10.1080\/10408398.2018.1437023","article-title":"Polyphenols and bioavailability: an update","volume":"59","author":"Teng","year":"2019","journal-title":"Crit. Rev. Food Sci. Nutr."},{"issue":"12\u201313","key":"10.1016\/j.bbih.2020.100128_bib93","doi-asserted-by":"crossref","first-page":"1217","DOI":"10.1016\/S0020-7519(00)00124-7","article-title":"Toxoplasma gondii: from animals to humans","volume":"30","author":"Tenter","year":"2000","journal-title":"Int. J. Parasitol."},{"key":"10.1016\/j.bbih.2020.100128_bib94","doi-asserted-by":"crossref","first-page":"33","DOI":"10.3389\/fnbeh.2019.00033","article-title":"Testosterone reduces fear and causes drastic hypomethylation of arginine vasopressin promoter in medial extended amygdala of male mice","volume":"13","author":"Tong","year":"2019","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbih.2020.100128_bib95","doi-asserted-by":"crossref","first-page":"501","DOI":"10.2471\/BLT.12.111732","article-title":"The global burden of congenital toxoplasmosis: a systematic review","volume":"91","author":"Torgerson","year":"2013","journal-title":"Bull. World Health Organ."},{"key":"10.1016\/j.bbih.2020.100128_bib96","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.neubiorev.2018.11.012","article-title":"Toxoplasmosis: a pathway to neuropsychiatric disorders","volume":"96","author":"Tyebji","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"10","key":"10.1016\/j.bbih.2020.100128_bib97","doi-asserted-by":"crossref","DOI":"10.1002\/mnfr.201801237","article-title":"Induction of autophagy and activation of SIRT-1 deacetylation mechanisms mediate neuroprotection by the pomegranate metabolite urolithin A in BV2 microglia and differentiated 3D human neural progenitor cells","volume":"63","author":"Velagapudi","year":"2019","journal-title":"Mol. Nutr. Food Res."},{"issue":"7","key":"10.1016\/j.bbih.2020.100128_bib98","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1004935","article-title":"Mechanisms of host behavioral change in Toxoplasma gondii rodent association","volume":"11","author":"Vyas","year":"2015","journal-title":"PLoS Pathog."},{"issue":"15","key":"10.1016\/j.bbih.2020.100128_bib99","doi-asserted-by":"crossref","first-page":"6442","DOI":"10.1073\/pnas.0608310104","article-title":"Behavioral changes induced by Toxoplasma infection of rodents are highly specific to aversion of cat odors","volume":"104","author":"Vyas","year":"2007","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"12","key":"10.1016\/j.bbih.2020.100128_bib100","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1016\/S1286-4579(01)01459-9","article-title":"Rats, cats, people and parasites: the impact of latent toxoplasmosis on behaviour","volume":"3","author":"Webster","year":"2001","journal-title":"Microb. Infect."},{"issue":"4","key":"10.1016\/j.bbih.2020.100128_bib101","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0004674","article-title":"Behavioral abnormalities in a mouse model of chronic toxoplasmosis are associated with MAG1 antibody levels and cyst burden","volume":"10","author":"Xiao","year":"2016","journal-title":"PLoS Neglected Trop. Dis."},{"issue":"3","key":"10.1016\/j.bbih.2020.100128_bib102","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1021\/acs.jafc.7b03285","article-title":"Urolithins attenuate LPS-induced neuroinflammation in BV2Microglia via MAPK, Akt, and NF-\u03baB signaling pathways","volume":"66","author":"Xu","year":"2018","journal-title":"J.\u00a0Agric. Food Chem."},{"issue":"1","key":"10.1016\/j.bbih.2020.100128_bib103","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1021\/acschemneuro.5b00260","article-title":"Pomegranate\u2019s neuroprotective effects against alzheimer\u2019s disease are mediated by urolithins, its ellagitannin-gut microbial derived metabolites","volume":"7","author":"Yuan","year":"2016","journal-title":"ACS Chem. Neurosci."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620300934?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620300934?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:21:44Z","timestamp":1762986104000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354620300934"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,10]]},"references-count":102,"alternative-id":["S2666354620300934"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100128","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2020,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Urolithin-A attenuates neurotoxoplasmosis and alters innate response towards predator odor","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100128","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100128"}}