{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T07:03:31Z","timestamp":1770966211169,"version":"3.50.1"},"reference-count":46,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100012698","name":"Jack Brockhoff Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100012698","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014607","name":"Royal Children's Hospital Foundation","doi-asserted-by":"publisher","award":["2018-984"],"award-info":[{"award-number":["2018-984"]}],"id":[{"id":"10.13039\/100014607","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1091124"],"award-info":[{"award-number":["APP1091124"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1102590"],"award-info":[{"award-number":["APP1102590"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["APP1123677"],"award-info":[{"award-number":["APP1123677"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003842","name":"Ilhan Food Allergy Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003842","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004752","name":"State Government of Victoria","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100004752","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008650","name":"Rotary Club of Eureka","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008650","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bbih.2020.100146","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T16:25:17Z","timestamp":1601310317000},"page":"100146","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Exposure to adversity and inflammatory outcomes in mid and late childhood"],"prefix":"10.1016","volume":"9","author":[{"given":"Meredith","family":"O'Connor","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anne-Louise","family":"Ponsonby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5438-480X","authenticated-orcid":false,"given":"Fiona","family":"Collier","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0949-9229","authenticated-orcid":false,"given":"Richard","family":"Liu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter D.","family":"Sly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Azzopardi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kate","family":"Lycett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sharon","family":"Goldfeld","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9497-1902","authenticated-orcid":false,"given":"Sarah J.","family":"Arnup","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Burgner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2246-0644","authenticated-orcid":false,"given":"Naomi","family":"Priest","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Vuillermin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mimi L.K.","family":"Tang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Richard","family":"Saffery","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John","family":"Carlin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Len","family":"Harrison","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbih.2020.100146_bib1","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.amepre.2010.03.015","article-title":"Building a framework for global surveillance of the public health implications of adverse childhood experiences","volume":"39","author":"Anda","year":"2010","journal-title":"Am. J. Prev. Med."},{"issue":"5","key":"10.1016\/j.bbih.2020.100146_bib2","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/mp.2015.67","article-title":"Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-\u03b1","volume":"21","author":"Baumeister","year":"2016","journal-title":"Mol. Psychiatr."},{"issue":"10","key":"10.1016\/j.bbih.2020.100146_bib3","doi-asserted-by":"crossref","first-page":"e517","DOI":"10.1016\/S2468-2667(19)30145-8","article-title":"Life course health consequences and associated annual costs of adverse childhood experiences across Europe and North America: a systematic review and meta-analysis","volume":"4","author":"Bellis","year":"2019","journal-title":"Lancet Pub. Health"},{"key":"10.1016\/j.bbih.2020.100146_bib4","doi-asserted-by":"crossref","first-page":"S51","DOI":"10.1016\/j.acap.2017.04.161","article-title":"Methods to assess adverse childhood experiences of children and families: toward approaches to promote child well-being in policy and practice","volume":"17","author":"Bethell","year":"2017","journal-title":"Acade. Pediatr."},{"issue":"10064","key":"10.1016\/j.bbih.2020.100146_bib5","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0140-6736(16)31389-7","article-title":"Early childhood development coming of age: science through the life course","volume":"389","author":"Black","year":"2017","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2020.100146_bib6","series-title":"Paper Presented at: ACSPRI Social Science Methodology Conference; December 10-13, 2006","article-title":"Measuring the socio-economic position of families in HILDA & LSAC","author":"Blakemore","year":"2006"},{"issue":"3","key":"10.1016\/j.bbih.2020.100146_bib7","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.paed.2017.12.008","article-title":"Adverse childhood experiences","volume":"28","author":"Boullier","year":"2018","journal-title":"Paediatr. Child Health"},{"issue":"Suppl. 2","key":"10.1016\/j.bbih.2020.100146_bib8","doi-asserted-by":"crossref","first-page":"17143","DOI":"10.1073\/pnas.1121264109","article-title":"Toward a new biology of social adversity","volume":"109","author":"Boyce","year":"2012","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"7","key":"10.1016\/j.bbih.2020.100146_bib9","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/j.acap.2016.11.015","article-title":"Prevent, screen, heal: collective action to fight the toxic effects of early life adversity","volume":"17","author":"Burke Harris","year":"2017","journal-title":"Acade. Pediatr."},{"key":"10.1016\/j.bbih.2020.100146_bib10","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1016\/j.bbi.2018.02.007","article-title":"Adverse childhood experiences and adult inflammation: findings from the 1958 British birth cohort","volume":"69","author":"Chen","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bbih.2020.100146_bib11","doi-asserted-by":"crossref","first-page":"259","DOI":"10.1037\/hea0000701","article-title":"Psychosocial stress and C-reactive protein from mid-adolescence to young adulthood","volume":"38","author":"Chiang","year":"2019","journal-title":"Health Psychol."},{"key":"10.1016\/j.bbih.2020.100146_bib12","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1136\/bmjopen-2017-020261","article-title":"Child Health CheckPoint Team. Child Health CheckPoint: cohort summary and methodology of a physical health and biospecimen module for the Longitudinal Study of Australian Children","volume":"9","author":"Clifford","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.bbih.2020.100146_bib13","series-title":"Longitudinal Study of Australian Children's Child Health CheckPoint Data User Guide","author":"Clifford","year":"2018"},{"key":"10.1016\/j.bbih.2020.100146_bib14","doi-asserted-by":"crossref","first-page":"j3683","DOI":"10.1136\/bmj.j3683","article-title":"Statistics notes: percentage differences, symmetry, and natural logarithms","volume":"358","author":"Cole","year":"2017","journal-title":"Br. Med. J."},{"issue":"5","key":"10.1016\/j.bbih.2020.100146_bib15","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1038\/s41390-019-0307-x","article-title":"Glycoprotein acetyls (GlycA) at 12 months are associated with high-sensitivity C-reactive protein and early life inflammatory immune measures","volume":"85","author":"Collier","year":"2019","journal-title":"Pediatr. Res."},{"issue":"4","key":"10.1016\/j.bbih.2020.100146_bib16","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1111\/jcpp.12891","article-title":"Commentary: biological embedding of childhood adversity: where do we go from here? A reflection on Koss and Gunnar (2018)","volume":"59","author":"Danese","year":"2018","journal-title":"JCPP (J. Child Psychol. Psychiatry)"},{"key":"10.1016\/j.bbih.2020.100146_bib17","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1146\/annurev-psych-010416-044208","article-title":"Hidden wounds? Inflammatory links between childhood trauma and psychopathology","volume":"68","author":"Danese","year":"2017","journal-title":"Annu. Rev. Psychol."},{"issue":"4","key":"10.1016\/j.bbih.2020.100146_bib18","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1073\/pnas.0610362104","article-title":"Childhood maltreatment predicts adult inflammation in a life-course study","author":"Danese","year":"2007","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"14","key":"10.1016\/j.bbih.2020.100146_bib19","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1056\/NEJMoa032804","article-title":"C-reactive protein and other circulating markers of inflammation in the prediction of coronary Heart disease","volume":"350","author":"Danesh","year":"2004","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbih.2020.100146_bib20","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.bbi.2018.02.013","article-title":"Rethinking IL-6 and CRP: why they are more than inflammatory biomarkers, and why it matters","volume":"70","author":"Del Giudice","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"Suppl. 3","key":"10.1016\/j.bbih.2020.100146_bib21","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1136\/bmjopen-2017-020900","article-title":"Metabolomics: population epidemiology and concordance in Australian children aged 11\u201312 years and their parents","volume":"9","author":"Ellul","year":"2019","journal-title":"BMJ open"},{"issue":"6","key":"10.1016\/j.bbih.2020.100146_bib22","doi-asserted-by":"crossref","first-page":"1342","DOI":"10.1037\/a0031808","article-title":"Cumulative risk and child development","volume":"13","author":"Evans","year":"2013","journal-title":"Psychol. Bull."},{"issue":"4","key":"10.1016\/j.bbih.2020.100146_bib23","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the Adverse Childhood Experiences (ACE) Study","volume":"14","author":"Felitti","year":"1998","journal-title":"Am. J. Prev. Med."},{"issue":"2","key":"10.1016\/j.bbih.2020.100146_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001606","article-title":"Biomarker profiling by nuclear magnetic resonance spectroscopy for the prediction of all-cause mortality: an observational study of 17,345 persons","volume":"11","author":"Fischer","year":"2014","journal-title":"PLoS Med."},{"issue":"7","key":"10.1016\/j.bbih.2020.100146_bib25","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1111\/jpc.13860","article-title":"Surveying social adversity in pregnancy: the antenatal risk burden experienced by Australian women","volume":"54","author":"Goldfeld","year":"2018","journal-title":"J.\u00a0Paediatr. Child Health"},{"issue":"8","key":"10.1016\/j.bbih.2020.100146_bib26","doi-asserted-by":"crossref","first-page":"e356","DOI":"10.1016\/S2468-2667(17)30118-4","article-title":"The effect of multiple adverse childhood experiences on health: a systematic review and meta-analysis","volume":"2","author":"Hughes","year":"2017","journal-title":"Lancet Pub. Health"},{"issue":"3","key":"10.1016\/j.bbih.2020.100146_bib27","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1007\/s10654-019-00501-w","article-title":"The disjunctive cause criterion by VanderWeele: an easy solution to a complex problem?","volume":"34","author":"Ikram","year":"2019","journal-title":"Eur. J. Epidemiol."},{"key":"10.1016\/j.bbih.2020.100146_bib28","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbi.2019.04.028","article-title":"Early life adversity exposure and circulating markers of inflammation in children and adolescents: a systematic review and meta-analysis","volume":"86","author":"Kuhlman","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.bbih.2020.100146_bib29","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1136\/jech-2016-208646","article-title":"Socioeconomic status in childhood and C reactive protein in adulthood: a systematic review and meta-analysis","volume":"71","author":"Liu","year":"2017","journal-title":"J.\u00a0Epidemiol. Community Health"},{"key":"10.1016\/j.bbih.2020.100146_bib30","series-title":"Measuring Domestic Violence in Longitudinal Research","author":"Loxton","year":"2017"},{"key":"10.1016\/j.bbih.2020.100146_bib31","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1016\/j.amepre.2018.10.016","article-title":"A\u00a0critical assessment of the adverse childhood experiences study at 20 years","volume":"56","author":"McEwen","year":"2019","journal-title":"Am. J. Prev. Med."},{"issue":"6","key":"10.1016\/j.bbih.2020.100146_bib32","doi-asserted-by":"crossref","first-page":"848","DOI":"10.1177\/0956797610370161","article-title":"Harsh family climate in early life presages the emergence of a proinflammatory phenotype in adolescence","volume":"21","author":"Miller","year":"2010","journal-title":"Psychol. Sci."},{"key":"10.1016\/j.bbih.2020.100146_bib33","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1146\/annurev.psych.60.110707.163551","article-title":"Health psychology: developing biologically plausible models linking the social world and physical health","volume":"60","author":"Miller","year":"2009","journal-title":"Annu. Rev. Psychol."},{"issue":"5","key":"10.1016\/j.bbih.2020.100146_bib34","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1016\/j.acap.2019.12.004","article-title":"Inequalities in the distribution of childhood adversity from birth to 11 years","volume":"20","author":"O'Connor","year":"2020","journal-title":"Acad. Pediatr."},{"key":"10.1016\/j.bbih.2020.100146_bib36","doi-asserted-by":"crossref","first-page":"S89","DOI":"10.3138\/cpp.2014-081","article-title":"The potential of social epigenetics for child health policy","author":"Park","year":"2015","journal-title":"Can. Publ. Pol.\/Anal. Polit."},{"issue":"1","key":"10.1016\/j.bbih.2020.100146_bib37","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1001\/2013.jamapsychiatry.4","article-title":"A\u00a0randomized controlled trial of the tumor necrosis factor antagonist infliximab for treatment-resistant depression: the role of baseline inflammatory biomarkers","volume":"70","author":"Raison","year":"2013","journal-title":"JAMA Psychia."},{"issue":"2","key":"10.1016\/j.bbih.2020.100146_bib38","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/jcpp.12928","article-title":"Cumulative childhood risk is associated with a new measure of chronic inflammation in adulthood","volume":"60","author":"Rasmussen","year":"2018","journal-title":"J.\u00a0Child Psychol. Psychiatry Allied Discip."},{"issue":"4","key":"10.1016\/j.bbih.2020.100146_bib39","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.cels.2015.09.007","article-title":"The biomarker GlycA is associated with chronic inflammation and predicts long-term risk of severe infection","volume":"1","author":"Ritchie","year":"2015","journal-title":"Cell Sys."},{"issue":"6","key":"10.1016\/j.bbih.2020.100146_bib40","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1891\/0886-6708.25.6.728","article-title":"Parent-child aggression: association with child abuse potential and parenting styles","volume":"25","author":"Rodriguez","year":"2010","journal-title":"Violence Vict."},{"key":"10.1016\/j.bbih.2020.100146_bib41","series-title":"Multiple Imputation for Nonresponse in Surveys","author":"Rubin","year":"1987"},{"issue":"5","key":"10.1016\/j.bbih.2020.100146_bib42","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1542\/peds.102.SE1.1287","article-title":"Environmental risk factors in infancy","volume":"102","author":"Sameroff","year":"1998","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbih.2020.100146_bib43","series-title":"LSAC Technical Paper No. 1. Sample Design","author":"Soloff","year":"2005"},{"key":"10.1016\/j.bbih.2020.100146_bib44","first-page":"1","article-title":"Principles of confounder selection","author":"VanderWeele","year":"2019","journal-title":"Eur. J. Epidemiol."},{"issue":"4","key":"10.1016\/j.bbih.2020.100146_bib45","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.1093\/ije\/dyv026","article-title":"Cohort profile: the Barwon infant study","volume":"44","author":"Vuillermin","year":"2015","journal-title":"Int. J. Epidemiol."},{"key":"10.1016\/j.bbih.2020.100146_bib46","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1002\/sim.4067","article-title":"Multiple imputation using chained equations: issues and guidance for practice","volume":"30","author":"White","year":"2010","journal-title":"Stat. Med."},{"key":"10.1016\/j.bbih.2020.100146_bib47","first-page":"1","article-title":"Directed acyclic graphs: a tool for causal studies in paediatrics","author":"Williams","year":"2018","journal-title":"Pediatr. Res."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620301113?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620301113?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:25:00Z","timestamp":1762986300000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354620301113"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":46,"alternative-id":["S2666354620301113"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100146","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Exposure to adversity and inflammatory outcomes in mid and late childhood","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100146","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100146"}}