{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T21:28:32Z","timestamp":1790544512863,"version":"4.1.0"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2020,12,1]],"date-time":"2020-12-01T00:00:00Z","timestamp":1606780800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2020,9,17]],"date-time":"2020-09-17T00:00:00Z","timestamp":1600300800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001691","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","award":["JP16K19317"],"award-info":[{"award-number":["JP16K19317"]}],"id":[{"id":"10.13039\/501100001691","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100014421","name":"EA Pharma Co., Ltd.","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100014421","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2020,12]]},"DOI":"10.1016\/j.bbih.2020.100149","type":"journal-article","created":{"date-parts":[[2020,9,22]],"date-time":"2020-09-22T17:42:49Z","timestamp":1600796569000},"page":"100149","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":32,"special_numbering":"C","title":["An enriched environment prevents cognitive impairment in an Alzheimer\u2019s disease model by enhancing the secretion of exosomal microRNA-146a from the choroid plexus"],"prefix":"10.1016","volume":"9","author":[{"given":"Masako","family":"Nakano","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Kubota","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shin","family":"Hashizume","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiji","family":"Kobayashi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takako S.","family":"Chikenji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuki","family":"Saito","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mineko","family":"Fujimiya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2020.100149_bib1","doi-asserted-by":"crossref","first-page":"181","DOI":"10.3389\/fneur.2014.00181","article-title":"Up-regulation of miRNA-146a in progressive, age-related inflammatory neurodegenerative disorders of the human CNS","volume":"5","author":"Alexandrov","year":"2014","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbih.2020.100149_bib2","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.2174\/1567205014666170706112701","article-title":"Developmental expression and dysregulation of miR-146a and miR-155 in down\u2019s syndrome and mouse models of down\u2019s syndrome and alzheimer\u2019s disease","volume":"14","author":"Arena","year":"2017","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbih.2020.100149_bib3","doi-asserted-by":"crossref","first-page":"534","DOI":"10.4103\/1673-5374.180372","article-title":"The choroid plexus-cerebrospinal fluid interface in Alzheimer\u2019s disease: more than just a barrier","volume":"11","author":"Balusu","year":"2016","journal-title":"Neural regeneration research"},{"key":"10.1016\/j.bbih.2020.100149_bib4","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.15252\/emmm.201606271","article-title":"Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles","volume":"8","author":"Balusu","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbih.2020.100149_bib5","doi-asserted-by":"crossref","first-page":"e304","DOI":"10.1038\/tp.2013.77","article-title":"Opposing actions of environmental enrichment and Alzheimer\u2019s disease on the expression of hippocampal microRNAs in mouse models","volume":"3","author":"Barak","year":"2013","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbih.2020.100149_bib6","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1126\/science.1252945","article-title":"Aging. Aging-induced type I interferon response at the choroid plexus negatively affects brain function","volume":"346","author":"Baruch","year":"2014","journal-title":"Science"},{"key":"10.1016\/j.bbih.2020.100149_bib7","doi-asserted-by":"crossref","first-page":"2264","DOI":"10.1073\/pnas.1211270110","article-title":"CNS-specific immunity at the choroid plexus shifts toward destructive Th2 inflammation in brain aging","volume":"110","author":"Baruch","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U.S.A."},{"key":"10.1016\/j.bbih.2020.100149_bib8","doi-asserted-by":"crossref","first-page":"7967","DOI":"10.1038\/ncomms8967","article-title":"Breaking immune tolerance by targeting Foxp3(+) regulatory T cells mitigates Alzheimer\u2019s disease pathology","volume":"6","author":"Baruch","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2020.100149_bib9","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1006\/bbrc.2000.3301","article-title":"Vasopressin V1a receptor signaling in a rat choroid plexus cell line","volume":"275","author":"Battle","year":"2000","journal-title":"Biochem. Biophys. Res. Commun."},{"key":"10.1016\/j.bbih.2020.100149_bib10","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1177\/0300985813502820","article-title":"MicroRNAs: history, biogenesis, and their evolving role in animal development and disease","volume":"51","author":"Bhaskaran","year":"2014","journal-title":"Veterinary pathology"},{"key":"10.1016\/j.bbih.2020.100149_bib11","doi-asserted-by":"crossref","first-page":"10884","DOI":"10.1523\/JNEUROSCI.2909-05.2005","article-title":"Choroid plexus megalin is involved in neuroprotection by serum insulin-like growth factor I","volume":"25","author":"Carro","year":"2005","journal-title":"J.\u00a0Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.bbih.2020.100149_bib12","doi-asserted-by":"crossref","first-page":"1618","DOI":"10.1016\/j.neurobiolaging.2005.09.039","article-title":"Blockade of the insulin-like growth factor I receptor in the choroid plexus originates Alzheimer\u2019s-like neuropathology in rodents: new cues into the human disease?","volume":"27","author":"Carro","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2020.100149_bib13","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1523\/JNEUROSCI.2544-04.2005","article-title":"3-Hydroxy-3-methylglutaryl-coenzyme A reductase inhibitors attenuate beta-amyloid-induced microglial inflammatory responses","volume":"25","author":"Cordle","year":"2005","journal-title":"J.\u00a0Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.bbih.2020.100149_bib14","doi-asserted-by":"crossref","first-page":"6986175","DOI":"10.1155\/2016\/6986175","article-title":"Exploring new inflammatory biomarkers and pathways during LPS-induced M1 polarization","volume":"2016","author":"Cunha","year":"2016","journal-title":"Mediat. Inflamm."},{"key":"10.1016\/j.bbih.2020.100149_bib15","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.it.2016.01.006","article-title":"Type I\/II interferon balance in the regulation of brain physiology and pathology","volume":"37","author":"Deczkowska","year":"2016","journal-title":"Trends Immunol."},{"key":"10.1016\/j.bbih.2020.100149_bib16","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1056\/NEJMoa1210951","article-title":"A\u00a0phase 3 trial of semagacestat for treatment of Alzheimer\u2019s disease","volume":"369","author":"Doody","year":"2013","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbih.2020.100149_bib17","doi-asserted-by":"crossref","first-page":"163","DOI":"10.14348\/molcells.2017.0011","article-title":"Signaling pathways controlling microglia chemotaxis","volume":"40","author":"Fan","year":"2017","journal-title":"Mol. Cell."},{"issue":"Suppl. 1","key":"10.1016\/j.bbih.2020.100149_bib18","doi-asserted-by":"crossref","first-page":"S123","DOI":"10.1016\/S0197-4580(03)00051-4","article-title":"Neurons, glia, and plasticity in normal brain aging","volume":"24","author":"Finch","year":"2003","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2020.100149_bib19","doi-asserted-by":"crossref","first-page":"e167","DOI":"10.1038\/cddis.2011.50","article-title":"Astrocytes are important mediators of Abeta-induced neurotoxicity and tau phosphorylation in primary culture","volume":"2","author":"Garwood","year":"2011","journal-title":"Cell Death Dis."},{"key":"10.1016\/j.bbih.2020.100149_bib20","doi-asserted-by":"crossref","first-page":"17","DOI":"10.3389\/fncel.2015.00017","article-title":"Choroid plexus dysfunction impairs beta-amyloid clearance in a triple transgenic mouse model of Alzheimer\u2019s disease","volume":"9","author":"Gonzalez-Marrero","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbih.2020.100149_bib21","doi-asserted-by":"crossref","first-page":"2123","DOI":"10.1038\/ncomms3123","article-title":"Choroid plexus transcytosis and exosome shuttling deliver folate into brain parenchyma","volume":"4","author":"Grapp","year":"2013","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2020.100149_bib22","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1126\/science.1072994","article-title":"The amyloid hypothesis of Alzheimer\u2019s disease: progress and problems on the road to therapeutics","volume":"297","author":"Hardy","year":"2002","journal-title":"Science"},{"key":"10.1016\/j.bbih.2020.100149_bib23","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.1096\/fj.09-136945","article-title":"Complex environment experience rescues impaired neurogenesis, enhances synaptic plasticity, and attenuates neuropathology in familial Alzheimer\u2019s disease-linked APPswe\/PS1DeltaE9 mice","volume":"24","author":"Hu","year":"2010","journal-title":"Faseb. J. : official publication of the Federation of American Societies for Experimental Biology"},{"key":"10.1016\/j.bbih.2020.100149_bib24","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0044789","article-title":"MicroRNA-146a: a key regulator of astrocyte-mediated inflammatory response","volume":"7","author":"Iyer","year":"2012","journal-title":"PloS One"},{"key":"10.1016\/j.bbih.2020.100149_bib25","doi-asserted-by":"crossref","first-page":"1712","DOI":"10.1038\/s41598-018-19442-7","article-title":"Activated forms of astrocytes with higher GLT-1 expression are associated with cognitive normal subjects with Alzheimer pathology in human brain","volume":"8","author":"Kobayashi","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2020.100149_bib26","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0204252","article-title":"An enriched environment prevents diabetes-induced cognitive impairment in rats by enhancing exosomal miR-146a secretion from endogenous bone marrow-derived mesenchymal stem cells","volume":"13","author":"Kubota","year":"2018","journal-title":"PloS One"},{"key":"10.1016\/j.bbih.2020.100149_bib27","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.molmet.2018.01.013","article-title":"Insulin-like growth factor receptor signaling regulates working memory, mitochondrial metabolism, and amyloid-beta uptake in astrocytes","volume":"9","author":"Logan","year":"2018","journal-title":"Molecular metabolism"},{"key":"10.1016\/j.bbih.2020.100149_bib28","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/j.omtn.2019.10.002","article-title":"Intranasal administration of miR-146a agomir rescued the pathological process and cognitive impairment in an AD mouse model","volume":"18","author":"Mai","year":"2019","journal-title":"Mol. Ther. Nucleic Acids"},{"key":"10.1016\/j.bbih.2020.100149_bib29","doi-asserted-by":"crossref","first-page":"136","DOI":"10.3389\/fncel.2015.00136","article-title":"The choroid plexus is modulated by various peripheral stimuli: implications to diseases of the central nervous system","volume":"9","author":"Marques","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbih.2020.100149_bib30","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1016\/j.neurobiolaging.2013.07.005","article-title":"MicroRNAs in Alzheimer\u2019s disease: differential expression in hippocampus and cell-free cerebrospinal fluid","volume":"35","author":"Muller","year":"2014","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2020.100149_bib31","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1038\/s41467-018-03507-2","article-title":"The choroid plexus is an important circadian clock component","volume":"9","author":"Myung","year":"2018","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2020.100149_bib32","doi-asserted-by":"crossref","first-page":"10772","DOI":"10.1038\/s41598-020-67460-1","article-title":"Bone marrow-derived mesenchymal stem cells improve cognitive impairment in an Alzheimer\u2019s disease model by increasing the expression of microRNA-146a in hippocampus","volume":"10","author":"Nakano","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2020.100149_bib33","doi-asserted-by":"crossref","first-page":"24805","DOI":"10.1038\/srep24805","article-title":"Bone marrow-derived mesenchymal stem cells improve diabetes-induced cognitive impairment by exosome transfer into damaged neurons and astrocytes","volume":"6","author":"Nakano","year":"2016","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2020.100149_bib34","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1016\/S0140-6736(00)03589-3","article-title":"Pathological correlates of late-onset dementia in a multicentre, community-based population in england and wales. Neuropathology group of the medical Research council cognitive function and ageing study (MRC CFAS)","volume":"357","author":"Neuropathology","year":"2001","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2020.100149_bib35","doi-asserted-by":"crossref","first-page":"10129","DOI":"10.1523\/JNEUROSCI.1202-06.2006","article-title":"Intraneuronal beta-amyloid aggregates, neurodegeneration, and neuron loss in transgenic mice with five familial Alzheimer\u2019s disease mutations: potential factors in amyloid plaque formation","volume":"26","author":"Oakley","year":"2006","journal-title":"J.\u00a0Neurosci. : the official journal of the Society for Neuroscience"},{"key":"10.1016\/j.bbih.2020.100149_bib36","doi-asserted-by":"crossref","first-page":"649","DOI":"10.1111\/bph.13139","article-title":"Microglial M1\/M2 polarization and metabolic states","volume":"173","author":"Orihuela","year":"2016","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbih.2020.100149_bib37","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1186\/s12974-017-0967-6","article-title":"Anti-inflammatory effects of astroglial alpha 7 nicotinic acetylcholine receptors are mediated by inhibition of the NF-kappaB pathway and activation of the Nrf 2 pathway","volume":"14","author":"Patel","year":"2017","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.bbih.2020.100149_bib38","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1152\/physrev.00041.2013","article-title":"Astrocyte reactivity and reactive astrogliosis: costs and benefits","volume":"94","author":"Pekny","year":"2014","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbih.2020.100149_bib39","doi-asserted-by":"crossref","first-page":"851","DOI":"10.3233\/JAD-131430","article-title":"Environmental enrichment lessens cognitive decline in APP23 mice without affecting brain sirtuin expression","volume":"42","author":"Polito","year":"2014","journal-title":"J.\u00a0Alzheim. Dis. : JAD"},{"key":"10.1016\/j.bbih.2020.100149_bib40","first-page":"E2403","article-title":"Environmental enrichment and exercise are better than social enrichment to reduce memory deficits in amyloid beta neurotoxicity","volume":"vol. 115","author":"Prado Lima","year":"2018"},{"key":"10.1016\/j.bbih.2020.100149_bib41","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1016\/j.bbi.2018.04.003","article-title":"An enriched environment restores hepatitis B vaccination-mediated impairments in synaptic function through IFN-gamma\/Arginase 1 signaling","volume":"71","author":"Qi","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2020.100149_bib42","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1056\/NEJMra0909142","article-title":"Alzheimer\u2019s disease","volume":"362","author":"Querfurth","year":"2010","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbih.2020.100149_bib43","doi-asserted-by":"crossref","first-page":"1796","DOI":"10.1038\/jcbfm.2009.96","article-title":"Enriched environment reduces apolipoprotein E (ApoE) in reactive astrocytes and attenuates inflammation of the peri-infarct tissue after experimental stroke","volume":"29","author":"Ruscher","year":"2009","journal-title":"J.\u00a0Cerebr. Blood Flow Metabol. : official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"key":"10.1016\/j.bbih.2020.100149_bib44","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1056\/NEJMoa1304839","article-title":"Two phase 3 trials of bapineuzumab in mild-to-moderate Alzheimer\u2019s disease","volume":"370","author":"Salloway","year":"2014","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbih.2020.100149_bib45","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/aps.2017.162","article-title":"Exosomes: new molecular targets of diseases","volume":"39","author":"Samanta","year":"2018","journal-title":"Acta Pharmacol. Sin."},{"key":"10.1016\/j.bbih.2020.100149_bib46","doi-asserted-by":"crossref","first-page":"2473","DOI":"10.15252\/embj.201797397","article-title":"APP mouse models for Alzheimer\u2019s disease preclinical studies","volume":"36","author":"Sasaguri","year":"2017","journal-title":"EMBO J."},{"key":"10.1016\/j.bbih.2020.100149_bib47","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ijdevneu.2007.05.010","article-title":"Beta\/A4-Amyloid increases nerve growth factor production in rat primary hippocampal astrocyte cultures","volume":"25","author":"Schulte-Herbruggen","year":"2007","journal-title":"Int. J. Dev. Neurosci. : the official journal of the International Society for Developmental Neuroscience"},{"key":"10.1016\/j.bbih.2020.100149_bib48","doi-asserted-by":"crossref","first-page":"3409","DOI":"10.1093\/hmg\/ddx230","article-title":"Astrocyte-produced miR-146a as a mediator of motor neuron loss in spinal muscular atrophy","volume":"26","author":"Sison","year":"2017","journal-title":"Hum. Mol. Genet."},{"key":"10.1016\/j.bbih.2020.100149_bib49","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0131340","article-title":"Immediate and long-term outcome of acute H2S intoxication induced coma in unanesthetized rats: effects of methylene blue","volume":"10","author":"Sonobe","year":"2015","journal-title":"PloS One"},{"key":"10.1016\/j.bbih.2020.100149_bib50","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1006\/exnr.2000.7545","article-title":"Human choroid plexus growth factors: what are the implications for CSF dynamics in Alzheimer\u2019s disease?","volume":"167","author":"Stopa","year":"2001","journal-title":"Exp. Neurol."},{"key":"10.1016\/j.bbih.2020.100149_bib51","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1038\/35044558","article-title":"Neural consequences of environmental enrichment","volume":"1","author":"van Praag","year":"2000","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbih.2020.100149_bib52","doi-asserted-by":"crossref","DOI":"10.3791\/52706","article-title":"Morris water maze test: optimization for mouse strain and testing environment","author":"Weitzner","year":"2015","journal-title":"JoVE"},{"key":"10.1016\/j.bbih.2020.100149_bib53","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1042\/AN20110025","article-title":"Early astrocytic atrophy in the entorhinal cortex of a triple transgenic animal model of Alzheimer\u2019s disease","volume":"3","author":"Yeh","year":"2011","journal-title":"ASN neuro"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620301149?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354620301149?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:22:37Z","timestamp":1762986157000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354620301149"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,12]]},"references-count":53,"alternative-id":["S2666354620301149"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100149","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2020,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"An enriched environment prevents cognitive impairment in an Alzheimer\u2019s disease model by enhancing the secretion of exosomal microRNA-146a from the choroid plexus","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2020.100149","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2020 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100149"}}