{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T16:06:53Z","timestamp":1787069213000,"version":"build-2736575974"},"reference-count":67,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,7,1]],"date-time":"2021-07-01T00:00:00Z","timestamp":1625097600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,4,14]],"date-time":"2021-04-14T00:00:00Z","timestamp":1618358400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"NIH","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2021,7]]},"DOI":"10.1016\/j.bbih.2021.100260","type":"journal-article","created":{"date-parts":[[2021,4,19]],"date-time":"2021-04-19T11:42:55Z","timestamp":1618832575000},"page":"100260","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":21,"special_numbering":"C","title":["Sex differences in a murine model of Cerebral Amyloid Angiopathy"],"prefix":"10.1016","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9250-4585","authenticated-orcid":false,"given":"Michael E.","family":"Maniskas","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexis F.","family":"Mack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Morales-Scheihing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carson","family":"Finger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liang","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7952-8526","authenticated-orcid":false,"given":"Robia","family":"Paulter","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akihiko","family":"Urayama","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise D.","family":"McCullough","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2852-6093","authenticated-orcid":false,"given":"Bharti","family":"Manwani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"7","key":"10.1016\/j.bbih.2021.100260_bib1","doi-asserted-by":"crossref","first-page":"1719","DOI":"10.1161\/STROKEAHA.117.020461","article-title":"Diverse inflammatory response after cerebral microbleeds includes coordinated microglial migration and proliferation","volume":"49","author":"Ahn","year":"2018","journal-title":"Stroke"},{"issue":"3","key":"10.1016\/j.bbih.2021.100260_bib2","first-page":"826","article-title":"Interleukin-2 improves amyloid pathology, synaptic failure and memory in Alzheimer\u2019s disease mice","volume":"140","author":"Alves","year":"2017","journal-title":"Brain"},{"issue":"4","key":"10.1016\/j.bbih.2021.100260_bib3","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/s11883-012-0254-z","article-title":"The pathophysiology and clinical presentation of cerebral amyloid angiopathy","volume":"14","author":"Auriel","year":"2012","journal-title":"Curr. Atherosclerosis Rep."},{"issue":"6","key":"10.1016\/j.bbih.2021.100260_bib4","doi-asserted-by":"crossref","first-page":"685","DOI":"10.1001\/archpsyc.62.6.685","article-title":"Sex differences in the clinical manifestations of Alzheimer disease pathology","volume":"62","author":"Barnes","year":"2005","journal-title":"Arch. Gen. Psychiatr."},{"issue":"8","key":"10.1016\/j.bbih.2021.100260_bib5","doi-asserted-by":"crossref","first-page":"2843","DOI":"10.1096\/fj.08-105866","article-title":"IFN-gamma enhances neurogenesis in wild-type mice and in a mouse model of Alzheimer\u2019s disease","volume":"22","author":"Baron","year":"2008","journal-title":"Faseb. J."},{"issue":"1","key":"10.1016\/j.bbih.2021.100260_bib6","doi-asserted-by":"crossref","first-page":"e89","DOI":"10.1002\/cpns.89","article-title":"Assaying fear memory discrimination and generalization: methods and concepts","volume":"91","author":"Bergstrom","year":"2020","journal-title":"Curr Protoc Neurosci"},{"key":"10.1016\/j.bbih.2021.100260_bib7","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neurobiolaging.2015.10.010","article-title":"The APOE4 allele shows opposite sex bias in microbleeds and Alzheimer\u2019s disease of humans and mice","volume":"37","author":"Cacciottolo","year":"2016","journal-title":"Neurobiol. Aging"},{"issue":"3","key":"10.1016\/j.bbih.2021.100260_bib8","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1016\/S0002-9440(10)64064-3","article-title":"Augmented senile plaque load in aged female beta-amyloid precursor protein-transgenic mice","volume":"158","author":"Callahan","year":"2001","journal-title":"Am. J. Pathol."},{"issue":"7","key":"10.1016\/j.bbih.2021.100260_bib9","doi-asserted-by":"crossref","first-page":"1829","DOI":"10.1093\/brain\/awx047","article-title":"Emerging concepts in sporadic cerebral amyloid angiopathy","volume":"140","author":"Charidimou","year":"2017","journal-title":"Brain"},{"key":"10.1016\/j.bbih.2021.100260_bib10","doi-asserted-by":"crossref","first-page":"130","DOI":"10.3389\/fnagi.2015.00130","article-title":"Menopause, obesity and inflammation: interactive risk factors for Alzheimer\u2019s disease","volume":"7","author":"Christensen","year":"2015","journal-title":"Front. Aging Neurosci."},{"issue":"6","key":"10.1016\/j.bbih.2021.100260_bib11","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0178490","article-title":"Age-dependent regulation of obesity and Alzheimer-related outcomes by hormone therapy in female 3xTg-AD mice","volume":"12","author":"Christensen","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2021.100260_bib12","series-title":"Methods of Behavior Analysis in Neuroscience. Frontiers in Neuroscience. Boca Raton (FL)","article-title":"Cued and contextual fear conditioning for rodents","author":"Curzon","year":"2009"},{"issue":"19","key":"10.1016\/j.bbih.2021.100260_bib13","doi-asserted-by":"crossref","first-page":"20296","DOI":"10.1074\/jbc.M312946200","article-title":"Early-onset and robust cerebral microvascular accumulation of amyloid beta-protein in transgenic mice expressing low levels of a vasculotropic Dutch\/Iowa mutant form of amyloid beta-protein precursor","volume":"279","author":"Davis","year":"2004","journal-title":"J.\u00a0Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbih.2021.100260_bib14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1161\/CIRCRESAHA.116.308426","article-title":"Vascular cognitive impairment","volume":"120","author":"Dichgans","year":"2017","journal-title":"Circ. Res."},{"key":"10.1016\/j.bbih.2021.100260_bib15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1111\/jnc.13607","article-title":"Neuroinflammation: the devil is in the details","volume":"139","author":"DiSabato","year":"2016","journal-title":"J.\u00a0Neurochem."},{"issue":"8","key":"10.1016\/j.bbih.2021.100260_bib16","doi-asserted-by":"crossref","first-page":"870","DOI":"10.2174\/1567205014666170317113606","article-title":"Impact of cytokines and chemokines on Alzheimer\u2019s disease neuropathological hallmarks","volume":"14","author":"Domingues","year":"2017","journal-title":"Curr. Alzheimer Res."},{"issue":"1","key":"10.1016\/j.bbih.2021.100260_bib17","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1186\/s12974-020-01770-z","article-title":"Interleukin-9 regulates macrophage activation in the progressive multiple sclerosis brain","volume":"17","author":"Donninelli","year":"2020","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.bbih.2021.100260_bib18","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.nicl.2017.05.002","article-title":"Amyloid positron emission tomography in sporadic cerebral amyloid angiopathy: a systematic critical update","volume":"15","author":"Farid","year":"2017","journal-title":"Neuroimage Clin"},{"issue":"2","key":"10.1016\/j.bbih.2021.100260_bib19","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1161\/STROKEAHA.118.023788","article-title":"Blood-brain barrier leakage and microvascular lesions in cerebral amyloid angiopathy","volume":"50","author":"Freeze","year":"2019","journal-title":"Stroke"},{"key":"10.1016\/j.bbih.2021.100260_bib20","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.neuint.2018.11.014","article-title":"Sex differences in risk factors for vascular contributions to cognitive impairment & dementia","volume":"127","author":"Gannon","year":"2019","journal-title":"Neurochem. Int."},{"issue":"2","key":"10.1016\/j.bbih.2021.100260_bib21","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1161\/STROKEAHA.117.016990","article-title":"Diagnosis of cerebral amyloid angiopathy: evolution of the Boston criteria","volume":"49","author":"Greenberg","year":"2018","journal-title":"Stroke"},{"issue":"4","key":"10.1016\/j.bbih.2021.100260_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1002\/9780470942390.mo150068","article-title":"Assessing cognition in mice","volume":"5","author":"Holter","year":"2015","journal-title":"Curr Protoc Mouse Biol"},{"issue":"4","key":"10.1016\/j.bbih.2021.100260_bib23","doi-asserted-by":"crossref","first-page":"844","DOI":"10.1016\/j.neuron.2013.10.008","article-title":"The pathobiology of vascular dementia","volume":"80","author":"Iadecola","year":"2013","journal-title":"Neuron"},{"issue":"9","key":"10.1016\/j.bbih.2021.100260_bib24","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1080\/13803395.2012.712676","article-title":"Greater cognitive deterioration in women than men with Alzheimer\u2019s disease: a meta analysis","volume":"34","author":"Irvine","year":"2012","journal-title":"J.\u00a0Clin. Exp. Neuropsychol."},{"issue":"19","key":"10.1016\/j.bbih.2021.100260_bib25","doi-asserted-by":"crossref","first-page":"2469","DOI":"10.1042\/CS20170033","article-title":"Animal models of cerebral amyloid angiopathy","volume":"131","author":"Jakel","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"issue":"2","key":"10.1016\/j.bbih.2021.100260_bib26","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1007\/s12640-015-9589-x","article-title":"Sex dimorphism profile of Alzheimer\u2019s disease-type pathologies in an APP\/PS1 mouse model","volume":"29","author":"Jiao","year":"2016","journal-title":"Neurotox. Res."},{"issue":"4","key":"10.1016\/j.bbih.2021.100260_bib27","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/j.1471-4159.2010.06958.x","article-title":"Experimental models of vascular dementia and vascular cognitive impairment: a systematic review","volume":"115","author":"Jiwa","year":"2010","journal-title":"J.\u00a0Neurochem."},{"issue":"5","key":"10.1016\/j.bbih.2021.100260_bib28","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1177\/0891988716654987","article-title":"Update on vascular dementia","volume":"29","author":"Khan","year":"2016","journal-title":"J.\u00a0Geriatr. Psychiatr. Neurol."},{"issue":"8","key":"10.1016\/j.bbih.2021.100260_bib29","doi-asserted-by":"crossref","first-page":"2052","DOI":"10.1016\/j.neurobiolaging.2013.02.015","article-title":"Small molecule p75NTR ligand prevents cognitive deficits and neurite degeneration in an Alzheimer\u2019s mouse model","volume":"34","author":"Knowles","year":"2013","journal-title":"Neurobiol. Aging"},{"issue":"1","key":"10.1016\/j.bbih.2021.100260_bib30","doi-asserted-by":"crossref","first-page":"54","DOI":"10.5498\/wjp.v6.i1.54","article-title":"Sex differences in cognitive impairment in Alzheimer\u2019s disease","volume":"6","author":"Laws","year":"2016","journal-title":"World J. Psychiatr."},{"key":"10.1016\/j.bbih.2021.100260_bib31","article-title":"Trace fear conditioning in mice","volume":"85","author":"Lugo","year":"2014","journal-title":"JoVE"},{"issue":"8","key":"10.1016\/j.bbih.2021.100260_bib32","doi-asserted-by":"crossref","first-page":"1689","DOI":"10.1016\/j.bbi.2011.06.015","article-title":"Functional recovery in aging mice after experimental stroke","volume":"25","author":"Manwani","year":"2011","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.bbih.2021.100260_bib33","doi-asserted-by":"crossref","first-page":"2076","DOI":"10.2353\/ajpath.2009.090059","article-title":"Interferon-{gamma} differentially affects Alzheimer\u2019s disease pathologies and induces neurogenesis in triple transgenic-AD mice","volume":"175","author":"Mastrangelo","year":"2009","journal-title":"Am. J. Pathol."},{"issue":"5","key":"10.1016\/j.bbih.2021.100260_bib34","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/S1474-4422(16)00067-3","article-title":"Sex differences in Alzheimer\u2019s disease and other dementias","volume":"15","author":"Mazure","year":"2016","journal-title":"Lancet Neurol."},{"issue":"12","key":"10.1016\/j.bbih.2021.100260_bib35","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1016\/j.jamda.2013.05.009","article-title":"Proinflammatory cytokines, aging, and age-related diseases","volume":"14","author":"Michaud","year":"2013","journal-title":"J.\u00a0Am. Med. Dir. Assoc."},{"key":"10.1016\/j.bbih.2021.100260_bib36","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.pneurobio.2017.05.003","article-title":"Brain interference: revisiting the role of IFNgamma in the central nervous system","volume":"156","author":"Monteiro","year":"2017","journal-title":"Prog. Neurobiol."},{"issue":"7","key":"10.1016\/j.bbih.2021.100260_bib37","doi-asserted-by":"crossref","first-page":"708","DOI":"10.1097\/NEN.0b013e31829a25b9","article-title":"APOE-epsilon2 and APOE-epsilon4 correlate with increased amyloid accumulation in cerebral vasculature","volume":"72","author":"Nelson","year":"2013","journal-title":"J.\u00a0Neuropathol. Exp. Neurol."},{"issue":"10","key":"10.1016\/j.bbih.2021.100260_bib38","doi-asserted-by":"crossref","first-page":"1178","DOI":"10.1001\/jamaneurol.2017.2188","article-title":"Apolipoprotein E genotype and sex risk factors for Alzheimer disease: a meta-analysis","volume":"74","author":"Neu","year":"2017","journal-title":"JAMA Neurol"},{"key":"10.1016\/j.bbih.2021.100260_bib39","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s12974-018-1313-3","article-title":"Inflammation: the link between comorbidities, genetics, and Alzheimer\u2019s disease","volume":"15","author":"Newcombe","year":"2018","journal-title":"J.\u00a0Neuroinflammation"},{"issue":"3","key":"10.1016\/j.bbih.2021.100260_bib40","doi-asserted-by":"crossref","first-page":"398","DOI":"10.3758\/BF03195394","article-title":"EthoVision: a versatile video tracking system for automation of behavioral experiments","volume":"33","author":"Noldus","year":"2001","journal-title":"Behav. Res. Methods Instrum. Comput."},{"issue":"6","key":"10.1016\/j.bbih.2021.100260_bib41","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1007\/s00401-018-1920-1","article-title":"Sex differences in Alzheimer\u2019s disease and common neuropathologies of aging","volume":"136","author":"Oveisgharan","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"4","key":"10.1016\/j.bbih.2021.100260_bib42","first-page":"803","article-title":"Gender difference in apolipoprotein E-associated risk for familial Alzheimer disease: a possible clue to the higher incidence of Alzheimer disease in women","volume":"58","author":"Payami","year":"1996","journal-title":"Am. J. Hum. Genet."},{"issue":"1","key":"10.1016\/j.bbih.2021.100260_bib43","first-page":"196","article-title":"Effects of brain-derived IL-2 deficiency and the development of Autoimmunity on spatial learning and fear conditioning","volume":"3","author":"Petitto","year":"2015","journal-title":"J\u00a0Neurol Disord"},{"issue":"2","key":"10.1016\/j.bbih.2021.100260_bib44","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1016\/j.jneumeth.2008.12.021","article-title":"Automated scoring of fear-related behavior using EthoVision software","volume":"178","author":"Pham","year":"2009","journal-title":"J.\u00a0Neurosci. Methods"},{"key":"10.1016\/j.bbih.2021.100260_bib45","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.00586","article-title":"Age and age-related diseases: role of inflammation triggers and cytokines","volume":"9","author":"Rea","year":"2018","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2021.100260_bib46","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1007\/s00401-018-1859-2","article-title":"Aging alters the immunological response to ischemic stroke","volume":"136","author":"Ritzel","year":"2018","journal-title":"Acta Neuropathol."},{"issue":"10","key":"10.1016\/j.bbih.2021.100260_bib47","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026612","article-title":"Cortical microhemorrhages cause local inflammation but do not trigger widespread dendrite degeneration","volume":"6","author":"Rosidi","year":"2011","journal-title":"PLoS One"},{"issue":"22","key":"10.1016\/j.bbih.2021.100260_bib48","doi-asserted-by":"crossref","first-page":"2067","DOI":"10.1056\/NEJMoa1105143","article-title":"Regulatory T-cell responses to low-dose interleukin-2 in HCV-induced vasculitis","volume":"365","author":"Saadoun","year":"2011","journal-title":"N.\u00a0Engl. J. Med."},{"key":"10.1016\/j.bbih.2021.100260_bib49","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1750-1326-10-1","article-title":"Abeta reduction in BACE1 heterozygous null 5XFAD mice is associated with transgenic APP level","volume":"10","author":"Sadleir","year":"2015","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbih.2021.100260_bib50","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.bbr.2018.11.022","article-title":"Cognitive decline in Tg2576 mice shows sex-specific differences and correlates with cerebral amyloid-beta","volume":"359","author":"Schmid","year":"2019","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2021.100260_bib51","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-2094-5-7","article-title":"The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective","volume":"5","author":"Shaftel","year":"2008","journal-title":"J.\u00a0Neuroinflammation"},{"issue":"2","key":"10.1016\/j.bbih.2021.100260_bib52","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1007\/s00401-016-1580-y","article-title":"Impact of sex and APOE4 on cerebral amyloid angiopathy in Alzheimer\u2019s disease","volume":"132","author":"Shinohara","year":"2016","journal-title":"Acta Neuropathol."},{"issue":"11","key":"10.1016\/j.bbih.2021.100260_bib53","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.1042\/CS20160607","article-title":"Clinical presentations and epidemiology of vascular dementia","volume":"131","author":"Smith","year":"2017","journal-title":"Clin. Sci. (Lond.)"},{"issue":"4","key":"10.1016\/j.bbih.2021.100260_bib54","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1007\/s11883-003-0048-4","article-title":"Clinical diagnosis of cerebral amyloid angiopathy: validation of the Boston criteria","volume":"5","author":"Smith","year":"2003","journal-title":"Curr. Atherosclerosis Rep."},{"issue":"1","key":"10.1016\/j.bbih.2021.100260_bib55","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.brainresbull.2011.10.004","article-title":"Role of pro-inflammatory cytokines released from microglia in neurodegenerative diseases","volume":"87","author":"Smith","year":"2012","journal-title":"Brain Res. Bull."},{"issue":"18","key":"10.1016\/j.bbih.2021.100260_bib56","doi-asserted-by":"crossref","first-page":"1916","DOI":"10.1212\/WNL.0000000000003288","article-title":"Female advantage in verbal memory: evidence of sex-specific cognitive reserve","volume":"87","author":"Sundermann","year":"2016","journal-title":"Neurology"},{"key":"10.1016\/j.bbih.2021.100260_bib57","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.neurobiolaging.2018.12.019","article-title":"Proinflammatory and anti-inflammatory cytokines in the CSF of patients with Alzheimer\u2019s disease and their correlation with cognitive decline","volume":"76","author":"Taipa","year":"2019","journal-title":"Neurobiol. Aging"},{"issue":"9","key":"10.1016\/j.bbih.2021.100260_bib58","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1089\/neu.2015.3977","article-title":"Performance of male and female C57BL\/6J mice on motor and cognitive tasks commonly used in pre-clinical traumatic brain injury research","volume":"33","author":"Tucker","year":"2016","journal-title":"J.\u00a0Neurotrauma"},{"issue":"6","key":"10.1016\/j.bbih.2021.100260_bib59","doi-asserted-by":"crossref","first-page":"H1128","DOI":"10.1152\/ajpheart.00780.2016","article-title":"Cerebral microhemorrhages: mechanisms, consequences, and prevention","volume":"312","author":"Ungvari","year":"2017","journal-title":"Am. J. Physiol. Heart Circ. Physiol."},{"key":"10.1016\/j.bbih.2021.100260_bib60","doi-asserted-by":"crossref","first-page":"18003","DOI":"10.1038\/nrdp.2018.3","article-title":"Vascular cognitive impairment","volume":"4","author":"van der Flier","year":"2018","journal-title":"Nat Rev Dis Primers"},{"issue":"2","key":"10.1016\/j.bbih.2021.100260_bib61","doi-asserted-by":"crossref","first-page":"483","DOI":"10.2353\/ajpath.2008.071191","article-title":"Tg-SwDI transgenic mice exhibit novel alterations in AbetaPP processing, Abeta degradation, and resilient amyloid angiopathy","volume":"173","author":"Van Vickle","year":"2008","journal-title":"Am. J. Pathol."},{"issue":"3","key":"10.1016\/j.bbih.2021.100260_bib62","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1016\/j.nbd.2003.08.009","article-title":"Gender differences in the amount and deposition of amyloidbeta in APPswe and PS1 double transgenic mice","volume":"14","author":"Wang","year":"2003","journal-title":"Neurobiol. Dis."},{"key":"10.1016\/j.bbih.2021.100260_bib63","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3389\/fnagi.2017.00157","article-title":"YXQN reduces Alzheimer\u2019s disease-like pathology and cognitive decline in APPswePS1dE9 transgenic mice","volume":"9","author":"Wang","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbih.2021.100260_bib64","first-page":"18","article-title":"Ageing, neurodegeneration and brain rejuvenation","author":"Wyss-Coray","year":"2016","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbih.2021.100260_bib65","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1007\/s12264-018-0268-9","article-title":"Sex differences in neuropathology and cognitive behavior in APP\/PS1\/tau triple-transgenic mouse model of Alzheimer\u2019s disease","volume":"34","author":"Yang","year":"2018","journal-title":"Neurosci Bull"},{"issue":"4","key":"10.1016\/j.bbih.2021.100260_bib66","doi-asserted-by":"crossref","first-page":"390","DOI":"10.1111\/bpa.12005","article-title":"A\u00a0shift in microglial beta-amyloid binding in Alzheimer\u2019s disease is associated with cerebral amyloid angiopathy","volume":"23","author":"Zabel","year":"2013","journal-title":"Brain Pathol."},{"issue":"3 Suppl. l","key":"10.1016\/j.bbih.2021.100260_bib67","first-page":"S16","article-title":"Cerebral amyloid angiopathy: progressive disruption of the neurovascular unit","volume":"40","author":"Zipfel","year":"2009","journal-title":"Stroke"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354621000636?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354621000636?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:25:45Z","timestamp":1762986345000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354621000636"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,7]]},"references-count":67,"alternative-id":["S2666354621000636"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2021.100260","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2021,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Sex differences in a murine model of Cerebral Amyloid Angiopathy","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2021.100260","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100260"}}