{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T10:33:31Z","timestamp":1779359611001,"version":"3.51.4"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,11,1]],"date-time":"2021-11-01T00:00:00Z","timestamp":1635724800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T00:00:00Z","timestamp":1630281600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI007613"],"award-info":[{"award-number":["T32 AI007613"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000918","name":"New York Community Trust","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000918","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001945","name":"American Psychological Foundation","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100001945","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006108","name":"National Center for Advancing Translational Sciences","doi-asserted-by":"publisher","award":["UL1TR000457"],"award-info":[{"award-number":["UL1TR000457"]}],"id":[{"id":"10.13039\/100006108","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000230","name":"Manitoba Arts Council","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000230","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000054","name":"National Cancer Institute","doi-asserted-by":"publisher","award":["K99 CA245488"],"award-info":[{"award-number":["K99 CA245488"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2021,11]]},"DOI":"10.1016\/j.bbih.2021.100342","type":"journal-article","created":{"date-parts":[[2021,8,31]],"date-time":"2021-08-31T02:25:47Z","timestamp":1630376747000},"page":"100342","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":5,"special_numbering":"C","title":["Childhood sexual abuse history amplifies the link between disease burden and inflammation among older adults with HIV"],"prefix":"10.1016","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0753-0859","authenticated-orcid":false,"given":"Heather M.","family":"Derry","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2828-8718","authenticated-orcid":false,"given":"Carrie D.","family":"Johnston","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9071-6659","authenticated-orcid":false,"given":"Mark","family":"Brennan-Ing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stephen","family":"Karpiak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9778-3213","authenticated-orcid":false,"given":"Chelsie O.","family":"Burchett","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yuan-Shan","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9449-5873","authenticated-orcid":false,"given":"Eugenia L.","family":"Siegler","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2145-148X","authenticated-orcid":false,"given":"Marshall J.","family":"Glesby","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbih.2021.100342_bib1","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1016\/S0749-3797(18)30622-6","article-title":"Screening for depression in well older adults: evaluation of a short form of the CES-D","volume":"10","author":"Andresen","year":"1994","journal-title":"Am. J. Prev. Med."},{"issue":"6","key":"10.1016\/j.bbih.2021.100342_bib2","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1016\/j.chiabu.2004.10.014","article-title":"A\u00a0meta-analysis of the relationship of child sexual abuse to HIV risk behavior among women","volume":"29","author":"Arriola","year":"2005","journal-title":"Child Abuse Negl."},{"issue":"6","key":"10.1016\/j.bbih.2021.100342_bib3","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1001\/jamapsychiatry.2019.0097","article-title":"Agreement between prospective and retrospective measures of childhood maltreatment: a systematic review and meta-analysis","volume":"76","author":"Baldwin","year":"2019","journal-title":"JAMA Psychiatr."},{"issue":"5","key":"10.1016\/j.bbih.2021.100342_bib4","doi-asserted-by":"crossref","first-page":"642","DOI":"10.1038\/mp.2015.67","article-title":"Childhood trauma and adulthood inflammation: a meta-analysis of peripheral C-reactive protein, interleukin-6 and tumour necrosis factor-\u03b1","volume":"21","author":"Baumeister","year":"2016","journal-title":"Mol. Psychiatr."},{"issue":"5","key":"10.1016\/j.bbih.2021.100342_bib5","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1016\/j.bbi.2011.11.007","article-title":"Inflammation and reactivation of latent herpesviruses in older adults","volume":"26","author":"Bennett","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2021.100342_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fmed.2018.00316","article-title":"Inflammation\u2013Nature\u2019s way to efficiently respond to all types of challenges: implications for understanding and managing \u201cthe epidemic\u201d of chronic diseases","volume":"5","author":"Bennett","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.bbih.2021.100342_bib7","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","author":"Bernstein","year":"1994","journal-title":"Am. J. Psychiatr. Am. J. Psychiatr."},{"issue":"3","key":"10.1016\/j.bbih.2021.100342_bib8","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1093\/infdis\/jiw173","article-title":"Interleukin 6 is a stronger predictor of clinical events than high-sensitivity C-reactive protein or D-dimer during HIV infection","volume":"214","author":"Borges","year":"2016","journal-title":"J.\u00a0Infect. Dis."},{"issue":"6","key":"10.1016\/j.bbih.2021.100342_bib9","doi-asserted-by":"crossref","first-page":"566","DOI":"10.1097\/PSY.0b013e31829683bd","article-title":"Varieties of anger and the inverse link between education and inflammation: toward an integrative framework","volume":"75","author":"Boylan","year":"2013","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbih.2021.100342_bib10","series-title":"The Experience and Impact of Interpersonal Violence Among Older Adults with HIV","author":"Brennan-Ing","year":"2020"},{"issue":"2","key":"10.1016\/j.bbih.2021.100342_bib11","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.psym.2014.10.006","article-title":"The syndemic illness of HIV and trauma: implications for a trauma-informed model of care","volume":"56","author":"Brezing","year":"2015","journal-title":"Psychosomatics"},{"key":"10.1016\/j.bbih.2021.100342_bib12","series-title":"Partial normalization of biomarkers of inflammation and immune activation among virally suppressed men with HIV infection and high ART adherence","volume":"7","author":"Castillo-Mancilla","year":"2020"},{"issue":"1","key":"10.1016\/j.bbih.2021.100342_bib13","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/npp.2016.198","article-title":"Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?","volume":"42","author":"Danese","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbih.2021.100342_bib14","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2018.00610","article-title":"Inflammatory measures in depressed patients with and without a history of adverse childhood experiences","volume":"9","author":"de Punder","year":"2018","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.bbih.2021.100342_bib15","article-title":"Links between inflammation, mood, and physical function among older adults with HIV","author":"Derry","year":"2021","journal-title":"J.\u00a0Gerontol. B"},{"key":"10.1016\/j.bbih.2021.100342_bib16","series-title":"HIV and Aging in San Francisco: Findings from the Research on Older Adults with HIV (ROAH) 2.0 San Francisco Study","author":"Erenrich","year":"2018"},{"issue":"3","key":"10.1016\/j.bbih.2021.100342_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1037\/a0028595","article-title":"Childhood adversity and herpesvirus latency in breast cancer survivors","volume":"32","author":"Fagundes","year":"2013","journal-title":"Health Psychol.: Off. J. Div. Health Psychol. Am. Psychol. Assoc."},{"issue":"4","key":"10.1016\/j.bbih.2021.100342_bib18","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/S0749-3797(98)00017-8","article-title":"Relationship of childhood abuse and household dysfunction to many of the leading causes of death in adults: the adverse childhood experiences (ACE) study","volume":"14","author":"Felitti","year":"1998","journal-title":"Am. J. Prev. Med."},{"issue":"12","key":"10.1016\/j.bbih.2021.100342_bib19","doi-asserted-by":"crossref","first-page":"1822","DOI":"10.1038\/s41591-019-0675-0","article-title":"Chronic inflammation in the etiology of disease across the life span","volume":"25","author":"Furman","year":"2019","journal-title":"Nat. Med."},{"issue":"1","key":"10.1016\/j.bbih.2021.100342_bib20","doi-asserted-by":"crossref","first-page":"143","DOI":"10.20411\/pai.v5i1.365","article-title":"Pathogenesis of aging and age-related comorbidities in people with HIV: highlights from the HIV ACTION workshop","volume":"5","author":"Gabuzda","year":"2020","journal-title":"Pathogen. Immun."},{"issue":"5","key":"10.1016\/j.bbih.2021.100342_bib21","doi-asserted-by":"crossref","first-page":"782","DOI":"10.1007\/s12160-017-9891-3","article-title":"Resilience resources moderate the association of adverse childhood experiences with adulthood inflammation","volume":"51","author":"Gouin","year":"2017","journal-title":"Ann. Behav. Med."},{"key":"10.1016\/j.bbih.2021.100342_bib22","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104509","article-title":"Interpersonal capitalization moderates the associations of chronic caregiving stress and depression with inflammation","volume":"112","author":"Gouin","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2021.100342_bib23","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.brat.2016.11.001","article-title":"Regression-based statistical mediation and moderation analysis in clinical research: observations, recommendations, and implementation","volume":"98","author":"Hayes","year":"2017","journal-title":"Behav. Res. Ther."},{"issue":"7","key":"10.1016\/j.bbih.2021.100342_bib24","doi-asserted-by":"crossref","first-page":"984","DOI":"10.1093\/cid\/cir989","article-title":"Does an index composed of clinical data reflect effects of inflammation, coagulation, and monocyte activation on mortality among those aging with HIV?","volume":"54","author":"Justice","year":"2012","journal-title":"Clin. Infect. Dis."},{"issue":"4","key":"10.1016\/j.bbih.2021.100342_bib25","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1007\/s11904-020-00509-y","article-title":"Immunomodulatory and anti-inflammatory strategies to reduce comorbidity risk in people with HIV","volume":"17","author":"Kettelhut","year":"2020","journal-title":"Curr. HIV AIDS Rep."},{"issue":"11","key":"10.1016\/j.bbih.2021.100342_bib26","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1176\/appi.ajp.2015.15020152","article-title":"Inflammation: depression fans the flames and feasts on the heat","volume":"172","author":"Kiecolt-Glaser","year":"2015","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.bbih.2021.100342_bib27","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.bbi.2019.04.028","article-title":"Early life adversity exposure and circulating markers of inflammation in children and adolescents: a systematic review and meta-analysis","volume":"86","author":"Kuhlman","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"11","key":"10.1016\/j.bbih.2021.100342_bib28","doi-asserted-by":"crossref","first-page":"1994","DOI":"10.1093\/aje\/kwz190","article-title":"Inflammation and risk of depression in HIV: prospective findings from the multicenter AIDS cohort study","volume":"188","author":"Lu","year":"2019","journal-title":"Am. J. Epidemiol."},{"key":"10.1016\/j.bbih.2021.100342_bib29","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.bbi.2020.08.006","article-title":"Early childhood adversity in adult patients with metastatic lung cancer: cross-sectional analysis of symptom burden and inflammation","volume":"90","author":"McFarland","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"11","key":"10.1016\/j.bbih.2021.100342_bib30","doi-asserted-by":"crossref","first-page":"1038","DOI":"10.1001\/jamapediatrics.2018.2537","article-title":"Prevalence of adverse childhood experiences from the 2011-2014 behavioral risk factor surveillance system in 23 states","volume":"172","author":"Merrick","year":"2018","journal-title":"JAMA Pediatr."},{"key":"10.1016\/j.bbih.2021.100342_bib31","article-title":"Influences of the menopause transition and adverse childhood experiences on peripheral basal inflammatory markers","volume":"15","author":"Metcalf","year":"2021","journal-title":"Brain, Behav. Immun. Health"},{"issue":"1","key":"10.1016\/j.bbih.2021.100342_bib32","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1038\/npp.2016.146","article-title":"Inflammation in fear- and anxiety-based disorders: PTSD, GAD, and beyond","volume":"42","author":"Michopoulos","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"6","key":"10.1016\/j.bbih.2021.100342_bib33","doi-asserted-by":"crossref","first-page":"959","DOI":"10.1037\/a0024768","article-title":"Psychological stress in childhood and susceptibility to the chronic diseases of aging: moving toward a model of behavioral and biological mechanisms","volume":"137","author":"Miller","year":"2011","journal-title":"Psychol. Bull."},{"issue":"7","key":"10.1016\/j.bbih.2021.100342_bib34","first-page":"833","article-title":"Is HIV a model of accelerated or accentuated aging?","volume":"69","author":"Pathai","year":"2014","journal-title":"J.\u00a0Gerontol. Series A, Biol. Sci. Med. Sci."},{"issue":"3","key":"10.1016\/j.bbih.2021.100342_bib35","doi-asserted-by":"crossref","first-page":"499","DOI":"10.1161\/01.CIR.0000052939.59093.45","article-title":"Markers of inflammation and cardiovascular disease application to clinical and public health practice: a statement for healthcare professionals from the centers for disease control and prevention and the American heart association","volume":"107","author":"Pearson","year":"2003","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bbih.2021.100342_bib36","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1097\/QCO.0000000000000510","article-title":"Assessing inflammation and its role in comorbidities among persons living with HIV","volume":"32","author":"Peterson","year":"2019","journal-title":"Curr. Opin. Infect. Dis."},{"key":"10.1016\/j.bbih.2021.100342_bib37","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1016\/j.bbi.2020.11.012","article-title":"Childhood abuse histories predict steeper inflammatory trajectories across time","volume":"91","author":"Renna","year":"2021","journal-title":"Brain Behav. Immun."},{"issue":"10","key":"10.1016\/j.bbih.2021.100342_bib38","doi-asserted-by":"crossref","first-page":"1031","DOI":"10.1001\/jamapsychiatry.2020.0431","article-title":"Psychosocial interventions and immune system function: a systematic review and meta-analysis of randomized clinical trials","volume":"77","author":"Shields","year":"2020","journal-title":"JAMA Psychiatr."},{"issue":"9939","key":"10.1016\/j.bbih.2021.100342_bib39","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1016\/S0140-6736(14)60604-8","article-title":"Trends in underlying causes of death in people with HIV from 1999 to 2011 (D:A:D): a multicohort collaboration","volume":"384","author":"Smith","year":"2014","journal-title":"Lancet"},{"issue":"5","key":"10.1016\/j.bbih.2021.100342_bib40","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1891\/vivi.19.5.507.63686","article-title":"A\u00a0short form of the Revised Conflict Tactics Scales, and typologies for severity and mutuality","volume":"19","author":"Straus","year":"2004","journal-title":"Violence Vict."},{"issue":"6","key":"10.1016\/j.bbih.2021.100342_bib41","doi-asserted-by":"crossref","first-page":"1653","DOI":"10.1007\/s10461-019-02684-5","article-title":"Adverse childhood experiences, smoking and alcohol use, and allostatic load among people living with HIV","volume":"24","author":"Wallace","year":"2020","journal-title":"AIDS Behav."},{"key":"10.1016\/j.bbih.2021.100342_bib42","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.bbi.2019.02.021","article-title":"Effects of SSRIs on peripheral inflammatory markers in patients with major depressive disorder: a systematic review and meta-analysis","volume":"79","author":"Wang","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2021.100342_bib43","volume":"vol. 10","author":"Weathers","year":"1994"},{"issue":"2","key":"10.1016\/j.bbih.2021.100342_bib44","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1037\/a0022915","article-title":"Pathways from childhood abuse and neglect to HIV-risk sexual behavior in middle adulthood","volume":"79","author":"Wilson","year":"2011","journal-title":"J.\u00a0Consult. Clin. Psychol."},{"key":"10.1016\/j.bbih.2021.100342_bib45","series-title":"Oxford Research Encyclopedia of Psychology","article-title":"Inflammation as a biomarker method in lifespan developmental methodology","author":"Wilson","year":"2018"},{"key":"10.1016\/j.bbih.2021.100342_bib46","series-title":"Adverse Childhood Experiences International Questionnaire","author":"World Health Organization","year":"2018"},{"key":"10.1016\/j.bbih.2021.100342_bib47","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.jad.2020.02.044","article-title":"Immune biomarkers alterations in post-traumatic stress disorder: a systematic review and meta-analysis","volume":"268","author":"Yang","year":"2020","journal-title":"J.\u00a0Affect. Disord."}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354621001459?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354621001459?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:25:19Z","timestamp":1762986319000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354621001459"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11]]},"references-count":47,"alternative-id":["S2666354621001459"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2021.100342","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2021,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Childhood sexual abuse history amplifies the link between disease burden and inflammation among older adults with HIV","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2021.100342","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100342"}}