{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T14:34:48Z","timestamp":1790174088475,"version":"4.1.0"},"reference-count":75,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2021,12,1]],"date-time":"2021-12-01T00:00:00Z","timestamp":1638316800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2021,9,29]],"date-time":"2021-09-29T00:00:00Z","timestamp":1632873600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2021,12]]},"DOI":"10.1016\/j.bbih.2021.100360","type":"journal-article","created":{"date-parts":[[2021,10,1]],"date-time":"2021-10-01T07:03:31Z","timestamp":1633071811000},"page":"100360","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":46,"special_numbering":"C","title":["Anxiety, depression, and asthma: New perspectives and approaches for psychoneuroimmunology research"],"prefix":"10.1016","volume":"18","author":[{"given":"Jasmine I.","family":"Caulfield","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2021.100360_bib1","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1097\/PSY.0b013e3182864ee3","article-title":"Examining the relationship between depression and asthma exacerbations in a prospective follow-up study","volume":"75","author":"Ahmedani","year":"2013","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbih.2021.100360_bib2","first-page":"1","article-title":"Trends in asthm a prevalence, health care use, and mortality in the United States, 2001-2010","volume":"94","author":"Akinbami","year":"2012","journal-title":"NCHS Data Brief"},{"key":"10.1016\/j.bbih.2021.100360_bib3","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-2354","article-title":"Changing trends in asthma prevalence among children","volume":"137","author":"Akinbami","year":"2016","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbih.2021.100360_bib4","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1164\/ajrccm.162.3.9908085","article-title":"Risk factors for pediatric asthma","volume":"162","author":"Aligne","year":"2000","journal-title":"Am. J. Respir. Crit. Care Med."},{"key":"10.1016\/j.bbih.2021.100360_bib5","doi-asserted-by":"crossref","first-page":"534","DOI":"10.1016\/j.yhbeh.2006.06.031","article-title":"Sex differences in depression and anxiety disorders: potential biological determinants","volume":"50","author":"Altemus","year":"2006","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbih.2021.100360_bib6","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1016\/j.rmed.2013.12.012","article-title":"Anxiety, depression and personality traits in severe, prednisone-dependent asthma","volume":"108","author":"Amelink","year":"2014","journal-title":"Respir. Med."},{"key":"10.1016\/j.bbih.2021.100360_bib7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.bbi.2017.01.015","article-title":"Immune activation in lactating dams alters sucklings' brain cytokines and produces non-overlapping behavioral deficits in adult female and male offspring: a novel neurodevelopmental model of sex-specific psychopathology","volume":"63","author":"Arad","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2021.100360_bib8","doi-asserted-by":"crossref","first-page":"1541","DOI":"10.1042\/CS20160487","article-title":"Cellular and molecular mechanisms of asthma and COPD","volume":"131","author":"Barnes","year":"2017","journal-title":"Clin. Sci."},{"key":"10.1016\/j.bbih.2021.100360_bib9","doi-asserted-by":"crossref","first-page":"514","DOI":"10.3390\/ph3030514","article-title":"Inhaled corticosteroids","volume":"3","author":"Barnes","year":"2010","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbih.2021.100360_bib10","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/S0140-6736(15)00156-7","article-title":"Risk factors for asthma: is prevention possible?","volume":"386","author":"Beasley","year":"2015","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2021.100360_bib11","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1289\/ehp.1306560","article-title":"Maternal stress and effects of prenatal air pollution on offspring mental health outcomes in mice","volume":"121","author":"Bolton","year":"2013","journal-title":"Environ. Health Perspect."},{"key":"10.1016\/j.bbih.2021.100360_bib12","doi-asserted-by":"crossref","first-page":"476","DOI":"10.3389\/fncel.2015.00476","article-title":"Neuroinflammation and depression: microglia activation, extracellular microvesicles and microRNA dysregulation","volume":"9","author":"Brites","year":"2015","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbih.2021.100360_bib13","first-page":"271","volume":"N 320","author":"Burrows","year":"1989","journal-title":"Association of asthma with serum IgE levels and skin-test reactivity to allergens"},{"key":"10.1016\/j.bbih.2021.100360_bib14","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1056\/NEJM200102013440507","volume":"344","author":"Busse","year":"2001","journal-title":"Asthma. N. Engl. J. Med."},{"key":"10.1016\/j.bbih.2021.100360_bib15","doi-asserted-by":"crossref","first-page":"226","DOI":"10.1016\/j.pharmthera.2011.01.014","article-title":"Immune system to brain signaling: neuropsychopharmacological implications","volume":"130","author":"Capuron","year":"2011","journal-title":"Pharmacol. Ther."},{"key":"10.1016\/j.bbih.2021.100360_bib16","doi-asserted-by":"crossref","first-page":"188","DOI":"10.3389\/fnbeh.2018.00188","article-title":"Asthma induction during development and adult lung function, behavior and brain gene expression","volume":"12","author":"Caulfield","year":"2018","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbih.2021.100360_bib17","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1016\/j.bbr.2017.02.046","article-title":"Peri-adolescent asthma symptoms cause adult anxiety-related behavior and neurobiological processes in mice","volume":"326","author":"Caulfield","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2021.100360_bib18","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00213-020-05666-x","article-title":"Inhaled corticosteroids as treatment for adolescent asthma: effects on adult anxiety-related outcomes in a murine model","volume":"238","author":"Caulfield","year":"2021","journal-title":"Psychopharmacology (Berlin)"},{"key":"10.1016\/j.bbih.2021.100360_bib19","doi-asserted-by":"crossref","first-page":"577450","DOI":"10.1016\/j.jneuroim.2020.577450","article-title":"Peri-adolescent asthma: acute impacts on innate immune response, corticosterone, and microglia in mice","volume":"350","author":"Caulfield","year":"2021","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.bbih.2021.100360_bib20","doi-asserted-by":"crossref","first-page":"453","DOI":"10.1080\/10253890.2018.1459557","article-title":"Timing matters: the interval between acute stressors withing chronic mild stress modifies behavioral and physiologic stress responses in male rats","volume":"21","author":"Cavigelli","year":"2018","journal-title":"Stress"},{"key":"10.1016\/j.bbih.2021.100360_bib21","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.jpsychires.2013.10.015","article-title":"Higher risk of developing major depression and bipolar disorder in later life among adolescents with asthma: a nationwide prospective study","volume":"49","author":"Chen","year":"2014","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.bbih.2021.100360_bib22","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1001\/archpsyc.60.8.837","article-title":"Prevalence and development of psychiatric disorders in childhood and adolescence","volume":"60","author":"Costello","year":"2003","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.bbih.2021.100360_bib23","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2018-027925","article-title":"Systematic review and meta-analysis of the association between peripheral inflammatory cytokines and generalised anxiety disorder","volume":"9","author":"Costello","year":"2019","journal-title":"BMJ Open"},{"key":"10.1016\/j.bbih.2021.100360_bib24","doi-asserted-by":"crossref","first-page":"1339","DOI":"10.1016\/S0149-2918(01)80113-2","article-title":"A\u00a0review of the pharmacology and pharmacokinetics of inhaled fluticasone propionate and mometasone furoate","volume":"23","author":"Crim","year":"2001","journal-title":"Clin. Therapeut."},{"key":"10.1016\/j.bbih.2021.100360_bib25","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1016\/j.envint.2018.09.036","article-title":"Short-term exposure to air pollution: associations with lung function and inflammatory markers in non-smoking, healthy adults","volume":"121","author":"Dauchet","year":"2018","journal-title":"Environ. Int."},{"key":"10.1016\/j.bbih.2021.100360_bib26","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41598-019-55539-3","article-title":"Allergen-induced anxiety-like behavior is associated with disruption of medial prefrontal cortex - amygdala circuit","volume":"9","author":"Dehdar","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2021.100360_bib27","first-page":"1","article-title":"Anxiety in youth with asthma: a meta-analysis","volume":"9999","author":"Dudeney","year":"2017","journal-title":"Pediatr. Pulmonol."},{"key":"10.1016\/j.bbih.2021.100360_bib28","first-page":"1","article-title":"Asthma prevalence among women aged 18 to 44 in the United States: national health and nutrition examination survey 2001\u20132016","author":"Flores","year":"2019","journal-title":"J.\u00a0Asthma"},{"key":"10.1016\/j.bbih.2021.100360_bib29","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1038\/mp.2011.76","article-title":"Air pollution impairs cognition, provokes depressive-like behaviors and alters hippocampal cytokine expression and morphology","volume":"16","author":"Fonken","year":"2011","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2021.100360_bib30","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/2045-7022-2-2","article-title":"Mechanisms of allergen-specific immunotherapy","volume":"2","author":"Fujita","year":"2012","journal-title":"Clin. Transl. Allergy"},{"key":"10.1016\/j.bbih.2021.100360_bib31","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jad.2008.07.022","article-title":"Immune system dysregulation in adolescent major depressive disorder","volume":"115","author":"Gabbay","year":"2009","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.bbih.2021.100360_bib32","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.resp.2019.05.004","article-title":"Altered brain network integrity in patients with asthma: a structural connectomic diffusion tensor imaging study","volume":"266","author":"Gao","year":"2019","journal-title":"Respir. Physiol. Neurobiol."},{"key":"10.1016\/j.bbih.2021.100360_bib33","doi-asserted-by":"crossref","first-page":"256","DOI":"10.1016\/j.jpeds.2018.09.021","article-title":"Prevalence and treatment of depression, anxiety, and conduct problems in US children","volume":"206","author":"Ghandour","year":"2019","journal-title":"J.\u00a0Pediatr."},{"key":"10.1016\/j.bbih.2021.100360_bib34","doi-asserted-by":"crossref","first-page":"468","DOI":"10.1016\/j.bbi.2010.11.008","article-title":"Effects of stressors and immune activating agents on peripheral and central cytokines in mouse strains that differ in stressor responsivity","volume":"25","author":"Gibb","year":"2011","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2021.100360_bib35","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1016\/j.bbi.2012.11.010","article-title":"Poly I: C-induced activation of the immune response is accompanied by depression and anxiety-like behaviours, kynurenine pathway activation and reduced BDNF expression","volume":"28","author":"Gibney","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2021.100360_bib36","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.otc.2007.11.007","article-title":"Asthma history and presentation","volume":"41","author":"Gordon","year":"2008","journal-title":"Otolaryngol. Clin."},{"key":"10.1016\/j.bbih.2021.100360_bib37","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.cyto.2015.05.014","article-title":"IL-4 and IL-13 signaling in allergic airway disease","volume":"75","author":"Gour","year":"2015","journal-title":"Cytokine"},{"key":"10.1016\/j.bbih.2021.100360_bib38","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1742-2094-5-15","article-title":"Minocycline attenuates lipopolysaccharide (LPS)-induced neuroinflammation, sickness behavior, and anhedonia","volume":"5","author":"Henry","year":"2008","journal-title":"J.\u00a0Neuroinflammation"},{"key":"10.1016\/j.bbih.2021.100360_bib39","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1111\/j.1365-2222.2008.02971.x","article-title":"Pathogenesis of asthma","volume":"38","author":"Holgate","year":"2008","journal-title":"Clin. Exp. Allergy"},{"key":"10.1016\/j.bbih.2021.100360_bib40","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1186\/s40413-016-0117-0","article-title":"The use of inhaled corticosteroids in pediatric asthma\u00a0\u200b: update","volume":"9","author":"Hossny","year":"2016","journal-title":"World Allergy Organ. J."},{"key":"10.1016\/j.bbih.2021.100360_bib41","article-title":"Sex differences in anxiety disorders: a review","volume":"4","author":"Jalnapurkar","year":"2018","journal-title":"J\u00a0Psychiatr Depress Anxiety"},{"key":"10.1016\/j.bbih.2021.100360_bib42","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.jadohealth.2007.05.023","article-title":"The Prevalence of DSM-IV anxiety and depressive disorders in youth with asthma compared with controls","volume":"41","author":"Katon","year":"2007","journal-title":"J.\u00a0Adolesc. Health"},{"key":"10.1016\/j.bbih.2021.100360_bib43","first-page":"168","article-title":"Lifetime prevalence and age-of-onset distributions of mental disorders in the World Health Organization's world mental health survey initiative","volume":"6","author":"Kessler","year":"2007","journal-title":"World Psychiatr."},{"key":"10.1016\/j.bbih.2021.100360_bib44","doi-asserted-by":"crossref","first-page":"24s","DOI":"10.1183\/09031936.01.00229601","article-title":"Cytokines in asthma","volume":"18","author":"Kips","year":"2001","journal-title":"Eur. Respir. J."},{"key":"10.1016\/j.bbih.2021.100360_bib45","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1097\/MCP.0000000000000248","article-title":"Pulmonary health effects of air pollution","volume":"22","author":"Kurt","year":"2016","journal-title":"Curr. Opin. Pulm. Med."},{"key":"10.1016\/j.bbih.2021.100360_bib46","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1016\/j.bbi.2020.04.084","article-title":"Modulation of fear behavior and neuroimmune alterations in house dust mite exposed A\/J mice, a model of severe asthma","volume":"88","author":"Lewkowich","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2021.100360_bib47","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1002\/alr.22464","article-title":"Worldwide asthma epidemiology: insights from the global health data exchange database","volume":"10","author":"Mattiuzzi","year":"2020","journal-title":"Int. Forum Allergy Rhinol."},{"key":"10.1016\/j.bbih.2021.100360_bib48","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1080\/02770900802444187","article-title":"Sex differences in asthma","volume":"45","author":"McCallister","year":"2008","journal-title":"J.\u00a0Asthma"},{"key":"10.1016\/j.bbih.2021.100360_bib49","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1016\/j.neuropharm.2011.07.014","article-title":"Stress and anxiety: structural plasticity and epigenetic regulation as a consequence of stress","volume":"62","author":"McEwen","year":"2012","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbih.2021.100360_bib50","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1016\/j.jaac.2013.11.013","article-title":"Inflammation in children and adolescents with neuropsychiatric disorders: a systematic review","volume":"53","author":"Mitchell","year":"2014","journal-title":"J.\u00a0Am. Acad. Child Adolesc. Psychiatry"},{"key":"10.1016\/j.bbih.2021.100360_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.envres.2020.109242","article-title":"Traffic-related particulate matter affects behavior, inflammation, and neural integrity in a developmental rodent model","volume":"183","author":"Nephew","year":"2020","journal-title":"Environ. Res."},{"key":"10.1016\/j.bbih.2021.100360_bib52","series-title":"National Institutes of Mental Health","year":"2021"},{"key":"10.1016\/j.bbih.2021.100360_bib53","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.jpsychires.2011.08.006","article-title":"Proinflammatory cytokines in the prefrontal cortex of teenage suicide victims","volume":"46","author":"Pandey","year":"2012","journal-title":"J.\u00a0Psychiatr. Res."},{"key":"10.1016\/j.bbih.2021.100360_bib54","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1600-0447.2009.01438.x","article-title":"The current status of urban-rural differences in psychiatric disorders","volume":"121","author":"Peen","year":"2010","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.bbih.2021.100360_bib55","first-page":"921","article-title":"Psychological considerations of the child with asthma","volume":"58","author":"Peters","year":"2011","journal-title":"Pediatr. Clin."},{"key":"10.1016\/j.bbih.2021.100360_bib56","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1542\/peds.2006-0249","article-title":"Asthma symptom burden: relationship to asthma severity and anxiety and depression symptoms","volume":"118","author":"Richardson","year":"2006","journal-title":"Pediatrics"},{"key":"10.1016\/j.bbih.2021.100360_bib57","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1016\/j.bbi.2017.01.016","article-title":"Microbes and mental health: a review","volume":"66","author":"Rieder","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2021.100360_bib58","doi-asserted-by":"crossref","first-page":"2341","DOI":"10.1007\/s11682-019-00188-3","article-title":"Subcortical gray matter volumes in asthma: associations with asthma duration, control, and anxiety","volume":"14","author":"Ritz","year":"2020","journal-title":"Brain Imaging Behav"},{"key":"10.1016\/j.bbih.2021.100360_bib59","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0040921","article-title":"Are there neurophenotypes for asthma? functional brain imaging of the interaction between emotion and inflammation in asthma","volume":"7","author":"Rosenkranz","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2021.100360_bib60","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1016\/j.bbi.2016.03.024","article-title":"Mind-body interactions in the regulation of airway inflammation in asthma: a PET study of acute and chronic stress","volume":"58","author":"Rosenkranz","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2021.100360_bib61","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.yhbeh.2012.02.018","article-title":"Sex, glia, and development: interactions in health and disease","volume":"62","author":"Schwarz","year":"2012","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbih.2021.100360_bib62","doi-asserted-by":"crossref","first-page":"3437","DOI":"10.1001\/jama.1992.03490240045034","article-title":"The influence of age and sex on asthma admissions","volume":"268","author":"Skobeloff","year":"1992","journal-title":"J.\u00a0Am. Med. Assoc."},{"key":"10.1016\/j.bbih.2021.100360_bib63","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1016\/S0149-7634(00)00014-2","article-title":"The adolescent brain and age-related behavioral manifestations","volume":"24","author":"Spear","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbih.2021.100360_bib64","doi-asserted-by":"crossref","first-page":"207","DOI":"10.3389\/fnbeh.2017.00207","article-title":"Microglial over-activation by social defeat stress contributes to anxiety-and depressive-like behaviors","volume":"11","author":"Stein","year":"2017","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbih.2021.100360_bib65","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1176\/ps.2008.59.12.1383","article-title":"Depression and anxiety in the United States: findings from the 2006 behavioral risk factor surveillance system","volume":"59","author":"Strine","year":"2008","journal-title":"Psychiatr. Serv."},{"key":"10.1016\/j.bbih.2021.100360_bib66","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.anai.2012.03.003","article-title":"Contribution of stress to asthma worsening through mast cell activation","volume":"109","author":"Theoharides","year":"2012","journal-title":"Ann. Allergy Asthma Immunol."},{"key":"10.1016\/j.bbih.2021.100360_bib67","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1186\/1471-2458-12-204","article-title":"Global asthma prevalence in adults: findings from the cross-sectional world health survey","volume":"12","author":"To","year":"2012","journal-title":"BMC Publ. Health"},{"key":"10.1016\/j.bbih.2021.100360_bib68","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1016\/j.bbi.2009.02.017","article-title":"Allergic rhinitis induces anxiety-like behavior and altered social interaction in rodents","volume":"23","author":"Tonelli","year":"2009","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2021.100360_bib69","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0165-0327(99)00110-X","article-title":"Prevalence of DSM IV anxiety and affective disorders in a pediatric population of asthmatic children and adolescents","volume":"58","author":"Vila","year":"2000","journal-title":"J.\u00a0Affect. Disord."},{"key":"10.1016\/j.bbih.2021.100360_bib70","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1186\/1742-4933-11-5","article-title":"Air pollution and subclinical airway inflammation in the SALIA cohort study","volume":"11","author":"Vossoughi","year":"2014","journal-title":"Immun. Ageing"},{"key":"10.1016\/j.bbih.2021.100360_bib71","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1017\/S0954579416000687","article-title":"The dynamics of internalizing and externalizing comorbidity across the early school years","volume":"28","author":"Wilner","year":"2016","journal-title":"Dev. Psychopathol."},{"key":"10.1016\/j.bbih.2021.100360_bib72","doi-asserted-by":"crossref","first-page":"1491","DOI":"10.1016\/j.psyneuen.2012.02.003","article-title":"Peripheral innate immune challenge exaggerated microglia activation, increased the number of inflammatory CNS macrophages, and prolonged social withdrawal in socially defeated mice","volume":"37","author":"Wohleb","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2021.100360_bib73","doi-asserted-by":"crossref","first-page":"922","DOI":"10.3109\/02770903.2016.1161050","article-title":"Altered intrinsic regional brain activity in female asthmatics with or without depressive symptoms: a resting-state functional magnetic resonance imaging study","volume":"53","author":"Xiong","year":"2016","journal-title":"J.\u00a0Asthma"},{"key":"10.1016\/j.bbih.2021.100360_bib74","doi-asserted-by":"crossref","first-page":"2814","DOI":"10.1016\/j.jaip.2020.04.041","article-title":"Recent trends in current asthma prevalence among US adults, 2009-2018","volume":"8","author":"Zhou","year":"2020","journal-title":"J.\u00a0Allergy Clin. Immunol. Pract."},{"key":"10.1016\/j.bbih.2021.100360_bib75","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.brainresbull.2018.09.006","article-title":"Chronic asthma-induced behavioral and hippocampal neuronal morphological changes are concurrent with BDNF, cofilin1 and Cdc42\/RhoA alterations in immature mice","volume":"143","author":"Zhuang","year":"2018","journal-title":"Brain Res. Bull."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354621001630?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354621001630?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:28:21Z","timestamp":1762986501000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354621001630"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12]]},"references-count":75,"alternative-id":["S2666354621001630"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2021.100360","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2021,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Anxiety, depression, and asthma: New perspectives and approaches for psychoneuroimmunology research","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2021.100360","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2021 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100360"}}