{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T10:13:57Z","timestamp":1781086437698,"version":"3.54.1"},"reference-count":85,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,2,26]],"date-time":"2022-02-26T00:00:00Z","timestamp":1645833600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.bbih.2022.100436","type":"journal-article","created":{"date-parts":[[2022,3,29]],"date-time":"2022-03-29T13:25:34Z","timestamp":1648560334000},"page":"100436","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":9,"special_numbering":"C","title":["Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6410-6654","authenticated-orcid":false,"given":"Marianne","family":"Foiselle","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susana","family":"Barbosa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oph\u00e9lia","family":"Godin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ching-Lien","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wahid","family":"Boukouaci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Myrtille","family":"Andre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bruno","family":"Aouizerate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Berna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Barau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Delphine","family":"Capdevielle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre","family":"Vidailhet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Chereau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laetitia","family":"Davidovic","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-Michel","family":"Dorey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline","family":"Dubertret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julien","family":"Dubreucq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catherine","family":"Faget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Fond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sylvain","family":"Leigner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierre-Michel","family":"Llorca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmina","family":"Mallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Misdrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emanuela","family":"Martinuzzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christine","family":"Passerieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Romain","family":"Rey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Baptiste","family":"Pignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Urbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Franck","family":"Sch\u00fcrhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Glaichenhaus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marion","family":"Leboyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3992-9565","authenticated-orcid":false,"given":"Ryad","family":"Tamouza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Berna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Haffen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leboyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Llorca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sch\u00fcrhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V.","family":"Barteau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Bensalem","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Godin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Laouamri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Souryis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Leboyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Offerlin-Meyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Pignon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Sch\u00fcrhoff","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Sz\u00f6ke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B.","family":"Aouizerate","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Deloge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Misdrahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Vil\u00e0","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"O.","family":"Blanc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"I.","family":"Ch\u00e9reau","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Denizot","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.M.","family":"Honciuc","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Lacelle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.M.","family":"Llorca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Pires","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Dubertret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Mallet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Portalier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.","family":"Dubreucq","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Fluttaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Gabayet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Roman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Chesnoy-Servanin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T.","family":"D'Amato","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J.M.","family":"Dorey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"R.","family":"Rey","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Vehier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Lan\u00e7on","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Faget","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"E.","family":"Metairie","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Peri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Vaillant","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L.","family":"Boyer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G.","family":"Fond","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F.","family":"Berna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P.","family":"Vidailhet","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A.","family":"Zinetti-Bertschy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D.","family":"Capdevielle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"Yazbek","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"S.","family":"Esselin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Jarroir","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Passerieux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M.","family":"Urbach","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"S22","key":"10.1016\/j.bbih.2022.100436_bib1","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1192\/S0007125000292581","article-title":"Assessing depression in schizophrenia : the calgary depression scale","volume":"163","author":"Addington","year":"1993","journal-title":"Br. J. Psychiatr."},{"issue":"11","key":"10.1016\/j.bbih.2022.100436_bib3","doi-asserted-by":"crossref","first-page":"1543","DOI":"10.1016\/j.metabol.2013.07.001","article-title":"Maladaptive immune and inflammatory pathways lead to cardiovascular insulin resistance","volume":"62","author":"Aroor","year":"2013","journal-title":"Metabolism"},{"key":"10.1016\/j.bbih.2022.100436_bib4","doi-asserted-by":"crossref","first-page":"16","DOI":"10.3389\/fnmol.2016.00016","article-title":"Inflammation and elevation of interleukin-12p40 in patients with schizophrenia","volume":"9","author":"Bedrossian","year":"2016","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbih.2022.100436_bib6","first-page":"1132","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","volume":"1132","author":"Bernstein","year":"1994","journal-title":"Am. J. Psychiatr."},{"issue":"5","key":"10.1016\/j.bbih.2022.100436_bib7","doi-asserted-by":"crossref","first-page":"446","DOI":"10.3390\/ph14050446","article-title":"Cytokine level changes in schizophrenia patients with and without metabolic syndrome treated with atypical antipsychotics","volume":"14","author":"Boiko","year":"2021","journal-title":"Pharmaceuticals"},{"key":"10.1016\/j.bbih.2022.100436_bib8","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.psyneuen.2015.03.003","article-title":"Increase systemic levels of IL-23 as a possible constitutive marker in schizophrenia","volume":"56","author":"Borovcanin","year":"2015","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/j.bbih.2022.100436_bib9","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1016\/j.neuroimage.2010.12.028","article-title":"Penalized least squares regression methods and applications to neuroimaging","volume":"55","author":"Bunea","year":"2011","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbih.2022.100436_bib10","article-title":"Mice : Multivariate imputation by chained equations in R","volume":"1\u201368","author":"Buuren","year":"2010","journal-title":"J.\u00a0Stat. Software"},{"issue":"4","key":"10.1016\/j.bbih.2022.100436_bib11","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1159\/000446543","article-title":"Inflammaging, metabolic syndrome and melatonin : a call for treatment studies","volume":"104","author":"Cardinali","year":"2017","journal-title":"Neuroendocrinology"},{"issue":"2\u20133","key":"10.1016\/j.bbih.2022.100436_bib12","doi-asserted-by":"crossref","first-page":"290","DOI":"10.1016\/j.schres.2016.01.010","article-title":"Cardiometabolic risk factors in young people at ultra-high risk for psychosis : a systematic review and meta-analysis","volume":"170","author":"Carney","year":"2016","journal-title":"Schizophr. Res."},{"issue":"5","key":"10.1016\/j.bbih.2022.100436_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019590","article-title":"Life expectancy at birth for people with serious mental illness and other major disorders from a secondary mental health care case register in London","volume":"6","author":"Chang","year":"2011","journal-title":"PLoS One"},{"issue":"15","key":"10.1016\/j.bbih.2022.100436_bib14","doi-asserted-by":"crossref","first-page":"3219","DOI":"10.1017\/S0033291716001902","article-title":"Impaired glucose tolerance in first-episode drug-naive patients with schizophrenia : relationships with clinical phenotypes and cognitive deficits","volume":"46","author":"Chen","year":"2016","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbih.2022.100436_bib15","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1016\/j.schres.2016.09.012","article-title":"Prevalence of metabolic syndrome in female and male patients at risk of psychosis","volume":"181","author":"Cordes","year":"2017","journal-title":"Schizophr. Res."},{"issue":"2","key":"10.1016\/j.bbih.2022.100436_bib16","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1002\/wps.20420","article-title":"Prevalence, incidence and mortality from cardiovascular disease in patients with pooled and specific severe mental illness : a large-scale meta-analysis of 3,211,768 patients and 113,383,368 controls","volume":"16","author":"Correll","year":"2017","journal-title":"World Psychiatr."},{"issue":"10","key":"10.1016\/j.bbih.2022.100436_bib17","doi-asserted-by":"crossref","first-page":"8170","DOI":"10.1007\/s12035-016-0309-1","article-title":"Functional implications of the IL-23\/IL-17 immune axis in schizophrenia","volume":"54","author":"Debnath","year":"2017","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbih.2022.100436_bib18","series-title":"Third Report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel III)","year":"2002"},{"issue":"1\u20133","key":"10.1016\/j.bbih.2022.100436_bib21","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1016\/j.schres.2010.02.1028","article-title":"Higher white blood cell counts are associated with an increased risk for metabolic syndrome and more severe psychopathology in non-diabetic patients with schizophrenia","volume":"118","author":"Fan","year":"2010","journal-title":"Schizophr. Res."},{"key":"10.1016\/j.bbih.2022.100436_bib22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.bbi.2020.12.025","article-title":"The intersection of inflammation and metabolism in neuropsychiatric disorders","volume":"93","author":"Felger","year":"2021","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2022.100436_bib23","series-title":"Structured Clinical Interview for DSM-IV axis I Disorders","author":"First","year":"1997"},{"issue":"10","key":"10.1016\/j.bbih.2022.100436_bib24","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1038\/s41574-018-0059-4","article-title":"Inflammaging : a new immune\u2013metabolic viewpoint for age-related diseases","volume":"14","author":"Franceschi","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib25","first-page":"1","article-title":"Regularization paths for generalized linear models via coordinate descent","volume":"33","author":"Friedman","year":"2010","journal-title":"J.\u00a0Stat. Software"},{"key":"10.1016\/j.bbih.2022.100436_bib26","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2018.05.002","article-title":"Profiling inflammatory signatures of schizophrenia : a cross-sectional and meta-analysis study","volume":"71","author":"Frydecka","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.bbih.2022.100436_bib27","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.cmet.2012.04.001","article-title":"Inflammation and lipid signaling in the etiology of insulin resistance","volume":"15","author":"Glass","year":"2012","journal-title":"Cell Metabol."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2022.100436_bib28","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1016\/j.schres.2015.07.047","article-title":"Metabolic syndrome, abdominal obesity and hyperuricemia in schizophrenia : results from the FACE-SZ cohort","volume":"168","author":"Godin","year":"2015","journal-title":"Schizophr. Res."},{"issue":"6","key":"10.1016\/j.bbih.2022.100436_bib29","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.17m12007","article-title":"Metabolic syndrome and illness severity predict relapse at 1-year follow-up in schizophrenia : the FACE-SZ cohort","volume":"79","author":"Godin","year":"2018","journal-title":"J.\u00a0Clin. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100436_bib31","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2020.00046","article-title":"Inflammation and negative symptoms of schizophrenia : implications for reward processing and motivational deficits","volume":"11","author":"Goldsmith","year":"2020","journal-title":"Front. Psychiatr."},{"issue":"3","key":"10.1016\/j.bbih.2022.100436_bib32","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1007\/s11121-007-0070-9","article-title":"How many imputations are really needed? Some practical clarifications of multiple imputation theory","volume":"8","author":"Graham","year":"2007","journal-title":"Prev. Sci."},{"key":"10.1016\/j.bbih.2022.100436_bib33","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1146\/annurev-immunol-031210-101322","article-title":"Inflammatory mechanisms in obesity","volume":"29","author":"Gregor","year":"2011","journal-title":"Annu. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.bbih.2022.100436_bib34","doi-asserted-by":"crossref","first-page":"452","DOI":"10.1016\/S2215-0366(15)00115-7","article-title":"Pathophysiological mechanisms of increased cardiometabolic risk in people with schizophrenia and other severe mental illnesses","volume":"2","author":"Henderson","year":"2015","journal-title":"Lancet Psychiatr."},{"issue":"8","key":"10.1016\/j.bbih.2022.100436_bib35","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1002\/da.22512","article-title":"Bidirectional prospective associations of metabolic syndrome components with depression, anxiety, and antidepressant use","volume":"33","author":"Hiles","year":"2016","journal-title":"Depress. Anxiety"},{"issue":"6","key":"10.1016\/j.bbih.2022.100436_bib36","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1016\/j.cell.2010.02.034","article-title":"Endoplasmic reticulum stress and the inflammatory basis of metabolic disease","volume":"140","author":"Hotamisligil","year":"2010","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbih.2022.100436_bib37","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1176\/appi.ajp.2016.16050503","article-title":"Treatment-resistant schizophrenia : treatment response and resistance in psychosis (TRRIP) working group consensus guidelines on diagnosis and terminology","volume":"174","author":"Howes","year":"2017","journal-title":"Am. J. Psychiatr."},{"issue":"2","key":"10.1016\/j.bbih.2022.100436_bib38","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1093\/schbul\/13.2.261","article-title":"The positive and negative syndrome scale (PANSS) for schizophrenia","volume":"13","author":"Kay","year":"1987","journal-title":"Schizophr. Bull."},{"key":"10.1016\/j.bbih.2022.100436_bib39","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/j.schres.2019.04.021","article-title":"Total and differential white blood cell counts, inflammatory markers, adipokines, and incident metabolic syndrome in phase 1 of the clinical antipsychotic trials of intervention effectiveness study","volume":"209","author":"Kelly","year":"2019","journal-title":"Schizophr. Res."},{"issue":"3","key":"10.1016\/j.bbih.2022.100436_bib40","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1016\/S2215-0366(14)00122-9","article-title":"Inflammation and immunity in schizophrenia : implications for pathophysiology and treatment","volume":"2","author":"Khandaker","year":"2015","journal-title":"Lancet Psychiatr."},{"issue":"3","key":"10.1016\/j.bbih.2022.100436_bib41","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.clim.2012.06.009","article-title":"Delivery of IL-12p40 ameliorates DSS-induced colitis by suppressing IL-17A expression and inflammation in the intestinal mucosa","volume":"144","author":"Kim","year":"2012","journal-title":"Clin. Immunol."},{"issue":"9","key":"10.1016\/j.bbih.2022.100436_bib42","doi-asserted-by":"crossref","first-page":"838","DOI":"10.1097\/PSY.0000000000000863","article-title":"Psychotic, mood, and anxiety disorders and venous thromboembolism : a systematic review and meta-analysis","volume":"82","author":"Kowal","year":"2020","journal-title":"Psychosom. Med."},{"issue":"2","key":"10.1016\/j.bbih.2022.100436_bib43","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s12038-018-9751-8","article-title":"Human cathelicidin LL-37\u2013Does it influence the homeostatic imbalance in mental disorders?","volume":"43","author":"Kozlowska","year":"2018","journal-title":"J.\u00a0Biosci."},{"key":"10.1016\/j.bbih.2022.100436_bib44","article-title":"Building predictive models in R using the caret package","volume":"28","author":"Kuhn","year":"2008","journal-title":"J.\u00a0Stat. Software"},{"issue":"7","key":"10.1016\/j.bbih.2022.100436_bib45","doi-asserted-by":"crossref","first-page":"1102","DOI":"10.1017\/S0033291717002483","article-title":"Metabolic and inflammatory markers : associations with individual depressive symptoms","volume":"48","author":"Lamers","year":"2018","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbih.2022.100436_bib46","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.bbi.2020.04.002","article-title":"Depression profilers and immuno-metabolic dysregulation : longitudinal results from the NESDA study","volume":"88","author":"Lamers","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bbih.2022.100436_bib47","article-title":"Metabolic syndrome and inflammation markers in patients with schizophrenia and recurrent depressive disorder","volume":"26","author":"Lasi\u0107","year":"2014","journal-title":"Psychiatr. Danub."},{"issue":"2","key":"10.1016\/j.bbih.2022.100436_bib48","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1097\/YCO.0b013e32835035ca","article-title":"Life expectancy and cardiovascular mortality in persons with schizophrenia","volume":"25","author":"Laursen","year":"2012","journal-title":"Curr. Opin. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100436_bib49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jpsychires.2019.06.011","article-title":"A\u00a0novel biomarker of cardiometabolic pathology in schizophrenia?","volume":"117","author":"Lee","year":"2019","journal-title":"J.\u00a0Psychiatr. Res."},{"issue":"10","key":"10.1016\/j.bbih.2022.100436_bib50","doi-asserted-by":"crossref","first-page":"2361","DOI":"10.1007\/s00125-015-3684-7","article-title":"IL-7 receptor deletion ameliorates diet-induced obesity and insulin resistance in mice","volume":"58","author":"Lee","year":"2015","journal-title":"Diabetologia"},{"key":"10.1016\/j.bbih.2022.100436_bib51","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.pnpbp.2018.04.006","article-title":"Relation of inflammatory markers with symptoms of psychotic disorders : a large cohort study","volume":"86","author":"Liemburg","year":"2018","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib52","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1007\/s00213-014-3650-y","article-title":"Decreased serum TNF-alpha levels in chronic schizophrenia patients on long-term antipsychotics : correlation with psychopathology and cognition","volume":"232","author":"Lv","year":"2015","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.bbih.2022.100436_bib54","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1007\/s10238-014-0323-4","article-title":"Metabolic syndrome and chronic arthritis : effects of anti-TNF-\u03b1 therapy","volume":"15","author":"Maruotti","year":"2015","journal-title":"Clin. Exp. Med."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib55","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.clindermatol.2017.09.004","article-title":"Pathophysiology of the metabolic syndrome","volume":"36","author":"McCracken","year":"2018","journal-title":"Clin. Dermatol."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib56","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/j.schres.2005.07.014","article-title":"Prevalence of the metabolic syndrome in patients with schizophrenia : baseline results from the Clinical Antipsychotic Trials of Intervention Effectiveness (CATIE) schizophrenia trial and comparison with national estimates from NHANES III","volume":"80","author":"McEvoy","year":"2005","journal-title":"Schizophr. Res."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib57","first-page":"17","article-title":"Metabolic syndrome and health-related quality of life in patients with schizophrenia","volume":"41","author":"Medeiros-Ferreira","year":"2013","journal-title":"Actas Esp. Psiquiatr."},{"issue":"7","key":"10.1016\/j.bbih.2022.100436_bib59","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.biopsych.2011.04.013","article-title":"Meta-analysis of cytokine alterations in schizophrenia : clinical status and antipsychotic effects","volume":"70","author":"Miller","year":"2011","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100436_bib60","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.bbi.2012.08.016","article-title":"Total and differential white blood cell counts, high-sensitivity C-reactive protein, and the metabolic syndrome in non-affective psychoses","volume":"31","author":"Miller","year":"2013","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib61","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-021-21533-5","article-title":"The neutrophil antimicrobial peptide cathelicidin promotes Th17 differentiation","volume":"12","author":"Minns","year":"2021","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bbih.2022.100436_bib62","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1093\/schbul\/sbr148","article-title":"Prevalence of metabolic syndrome and metabolic abnormalities in schizophrenia and related disorders\u2014a systematic review and meta-analysis","volume":"39","author":"Mitchell","year":"2013","journal-title":"Schizophr. Bull."},{"issue":"5","key":"10.1016\/j.bbih.2022.100436_bib63","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1093\/schbul\/sbv028","article-title":"Cortisol and inflammatory biomarkers predict poor treatment response in first episode psychosis","volume":"41","author":"Mondelli","year":"2015","journal-title":"Schizophr. Bull."},{"issue":"8","key":"10.1016\/j.bbih.2022.100436_bib64","doi-asserted-by":"crossref","first-page":"963","DOI":"10.2174\/1381612822666151215102420","article-title":"The many neuroprogressive actions of tryptophan catabolites (TRYCATs) that may be associated with the pathophysiology of neuro-immune disorders","volume":"22","author":"Morris","year":"2016","journal-title":"Curr. Pharmaceut. Des."},{"issue":"8","key":"10.1016\/j.bbih.2022.100436_bib65","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1089\/met.2014.0164","article-title":"Relationship between serum IL-12 and p40 subunit concentrations and lipid parameters in overweight and obese women","volume":"13","author":"Nikolajuk","year":"2015","journal-title":"Metab. Syndr. Relat. Disord."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib68","doi-asserted-by":"crossref","first-page":"63","DOI":"10.31887\/DCNS.2018.20.1\/bpenninx","article-title":"Metabolic syndrome in psychiatric patients : overview, mechanisms, and implications","volume":"20","author":"Penninx","year":"2018","journal-title":"Dialogues Clin. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib69","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/andr.12296","article-title":"Metabolic syndrome and the seminal cytokine network in morbidly obese males","volume":"5","author":"Pilatz","year":"2017","journal-title":"Andrology"},{"issue":"3","key":"10.1016\/j.bbih.2022.100436_bib70","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1001\/jamapsychiatry.2016.3803","article-title":"Impaired glucose homeostasis in first-episode schizophrenia : a systematic review and meta-analysis","volume":"74","author":"Pillinger","year":"2017","journal-title":"JAMA Psychiatr."},{"issue":"6","key":"10.1016\/j.bbih.2022.100436_bib71","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1192\/bjp.bp.117.200907","article-title":"Cholesterol and triglyceride levels in first-episode psychosis : systematic review and meta-analysis","volume":"211","author":"Pillinger","year":"2017","journal-title":"Br. J. Psychiatr."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib72","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S2215-0366(19)30416-X","article-title":"Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology : a systematic review and network meta-analysis","volume":"7","author":"Pillinger","year":"2020","journal-title":"Lancet Psychiatr."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib74","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1210\/jc.2017-01625","article-title":"Associations between cellular aging markers and metabolic syndrome : findings from the CARDIA study","volume":"103","author":"R\u00e9v\u00e9sz","year":"2018","journal-title":"J.\u00a0Clin. Endocrinol. Metabol."},{"key":"10.1016\/j.bbih.2022.100436_bib75","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.phrs.2015.07.022","article-title":"Metabolic syndrome and obesity among users of second generation antipsychotics : a global challenge for modern psychopharmacology","volume":"101","author":"Rojo","year":"2015","journal-title":"Pharmacol. Res."},{"issue":"2","key":"10.1016\/j.bbih.2022.100436_bib76","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1176\/appi.ajp.160.2.284","article-title":"Impaired fasting glucose tolerance in first-episode, drug-naive patients with schizophrenia","volume":"160","author":"Ryan","year":"2003","journal-title":"Am. J. Psychiatr."},{"issue":"2","key":"10.1016\/j.bbih.2022.100436_bib77","first-page":"238","article-title":"Expression of interleukins 7 & 8 in peripheral blood mononuclear cells from patients with metabolic syndrome : a preliminary study","volume":"140","author":"Saidijam","year":"2014","journal-title":"Indian J. Med. Res."},{"issue":"7","key":"10.1016\/j.bbih.2022.100436_bib78","doi-asserted-by":"crossref","first-page":"630","DOI":"10.2174\/1389202919666180726125645","article-title":"A\u00a0network biology approach for assessing the role of pathologic adipose tissues in insulin resistance using meta-analysis of microarray datasets","volume":"19","author":"Saxena","year":"2018","journal-title":"Curr. Genom."},{"issue":"6","key":"10.1016\/j.bbih.2022.100436_bib96","doi-asserted-by":"crossref","first-page":"728","DOI":"10.1016\/j.eurpsy.2015.05.004","article-title":"FondaMental Academic Centers of Expertise for Schizophrenia (FACE-SZ) collaborators","volume":"30","author":"Sch\u00fcrhoff","year":"2015","journal-title":"Eur Psychiatry"},{"issue":"4","key":"10.1016\/j.bbih.2022.100436_bib79","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1530\/EC-17-0011","article-title":"Sex, BMI and age differences in metabolic syndrome : the Dutch Lifelines Cohort Study","volume":"6","author":"Slagter","year":"2017","journal-title":"Endocrine Connect."},{"issue":"5","key":"10.1016\/j.bbih.2022.100436_bib80","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1111\/j.1464-5491.2007.02092.x","article-title":"Impaired glucose tolerance in first-episode drug-na\u00efve patients with schizophrenia","volume":"24","author":"Spelman","year":"2007","journal-title":"Diabet. Med."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib81","doi-asserted-by":"crossref","first-page":"25","DOI":"10.7150\/ijms.13800","article-title":"Systematic review of metabolic syndrome biomarkers : a panel for early detection, management, and risk stratification in the West Virginian population","volume":"13","author":"Srikanthan","year":"2016","journal-title":"Int. J. Med. Sci."},{"issue":"4","key":"10.1016\/j.bbih.2022.100436_bib82","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1348\/014466502760387533","article-title":"The concurrent validity of the global assessment of functioning (GAF)","volume":"41","author":"Startup","year":"2002","journal-title":"Br. J. Clin. Psychol."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib83","doi-asserted-by":"crossref","first-page":"100050","DOI":"10.1016\/j.cytox.2020.100050","article-title":"Relationships between plasma levels and six proinflammatory interleukins and body composition using a new magnetic resonance imaging voxel-based technique","volume":"3","author":"Strand","year":"2021","journal-title":"Cytokine X"},{"issue":"4","key":"10.1016\/j.bbih.2022.100436_bib84","doi-asserted-by":"crossref","first-page":"596","DOI":"10.1016\/j.clnu.2013.10.003","article-title":"Alcohol consumption and risk of metabolic syndrome : a meta-analysis of prospective studies","volume":"33","author":"Sun","year":"2014","journal-title":"Clin. Nutr."},{"key":"10.1016\/j.bbih.2022.100436_bib85","doi-asserted-by":"crossref","first-page":"941","DOI":"10.2147\/NDT.S47450","article-title":"Prevalence of metabolic syndrome and its association with depression in patients with schizophrenia","volume":"9","author":"Suttajit","year":"2013","journal-title":"Neuropsychiatric Dis. Treat."},{"key":"10.1016\/j.bbih.2022.100436_bib86","doi-asserted-by":"crossref","first-page":"408","DOI":"10.1016\/j.pnpbp.2017.07.023","article-title":"The role of Th17 cells in auto-inflammatory neurological disorders","volume":"79","author":"Tahmasebinia","year":"2017","journal-title":"Prog. Neuro Psychopharmacol. Biol. Psychiatr."},{"issue":"2","key":"10.1016\/j.bbih.2022.100436_bib87","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/acps.13125","article-title":"The HLA 8.1 ancestral haplotype in schizophrenia : dual implication in neuro-synaptic pruning and autoimmunity?","volume":"141","author":"Tamouza","year":"2020","journal-title":"Acta Psychiatr. Scand."},{"issue":"15","key":"10.1016\/j.bbih.2022.100436_bib88","doi-asserted-by":"crossref","first-page":"8732","DOI":"10.1073\/pnas.161126098","article-title":"IL-7 is critical for homeostatic proliferation and survival of naive T cells","volume":"98","author":"Tan","year":"2001","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"1","key":"10.1016\/j.bbih.2022.100436_bib89","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/sj.ijo.0801840","article-title":"Increased visceral fat distribution in drug-naive and drug-free patients with schizophrenia","volume":"26","author":"Thakore","year":"2002","journal-title":"Int. J. Obes."},{"issue":"3","key":"10.1016\/j.bbih.2022.100436_bib90","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1079\/BJN20041213","article-title":"Adipokines : inflammation and the pleiotropic role of white adipose tissue","volume":"92","author":"Trayhurn","year":"2004","journal-title":"Br. J. Nutr."},{"issue":"3","key":"10.1016\/j.bbih.2022.100436_bib91","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1002\/wps.20252","article-title":"Risk of metabolic syndrome and its components in people with schizophrenia and related psychotic disorders, bipolar disorder and major depressive disorder : a systematic review and meta-analysis","volume":"14","author":"Vancampfort","year":"2015","journal-title":"World Psychiatr."},{"issue":"6","key":"10.1016\/j.bbih.2022.100436_bib92","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1007\/s00038-013-0501-2","article-title":"Metabolic syndrome and socioeconomic status in France : the French Nutrition and Health Survey (ENNS, 2006\u20132007)","volume":"58","author":"Vernay","year":"2013","journal-title":"Int. J. Publ. Health"},{"issue":"5","key":"10.1016\/j.bbih.2022.100436_bib94","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1192\/bjp.133.5.429","article-title":"A\u00a0rating scale for mania : reliability, validity and sensitivity","volume":"133","author":"Young","year":"1978","journal-title":"Br. J. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100436_bib95","first-page":"46","article-title":"Circulating interleukin-16 in blood of patients with metabolic syndrome and type 2 diabetes mellitus","volume":"5\u20136","author":"Zak","year":"2007","journal-title":"Likars'Ka Sprava"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354622000266?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354622000266?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:27:14Z","timestamp":1762986434000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354622000266"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":85,"alternative-id":["S2666354622000266"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2022.100436","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Immuno-metabolic profile of patients with psychotic disorders and metabolic syndrome. Results from the FACE-SZ cohort","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2022.100436","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100436"}}