{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,18]],"date-time":"2026-05-18T14:28:14Z","timestamp":1779114494050,"version":"3.51.4"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,4,10]],"date-time":"2022-04-10T00:00:00Z","timestamp":1649548800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2022,7]]},"DOI":"10.1016\/j.bbih.2022.100461","type":"journal-article","created":{"date-parts":[[2022,4,11]],"date-time":"2022-04-11T21:43:07Z","timestamp":1649713387000},"page":"100461","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":19,"special_numbering":"C","title":["Chronic stress increases transcriptomic indicators of biological aging in mouse bone marrow leukocytes"],"prefix":"10.1016","volume":"22","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1887-3953","authenticated-orcid":false,"given":"Kelly E.","family":"Rentscher","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Judith E.","family":"Carroll","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lilian R.","family":"Polsky","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Donald M.","family":"Lamkin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"5","key":"10.1016\/j.bbih.2022.100461_bib1","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1182\/blood-2018-04-845420","article-title":"Acute myeloid leukemia induces protumoral p16INK4a-driven senescence in the bone marrow microenvironment","volume":"133","author":"Abdul-Aziz","year":"2019","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bbih.2022.100461_bib2","doi-asserted-by":"crossref","first-page":"1698","DOI":"10.1016\/j.psyneuen.2013.02.004","article-title":"Good stress, bad stress and oxidative stress: insights from anticipatory cortisol reactivity","volume":"38","author":"Aschbacher","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1006\/hbeh.2001.1653","article-title":"Social stress induces glucocorticoid resistance in subordinate animals","volume":"39","author":"Avitsur","year":"2001","journal-title":"Horm. Behav."},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib4","doi-asserted-by":"crossref","first-page":"241","DOI":"10.1007\/s00204-011-0674-5","article-title":"The cytoprotective role of the Keap1-Nrf2 pathway","volume":"85","author":"Baird","year":"2011","journal-title":"Arch. Toxicol."},{"issue":"7372","key":"10.1016\/j.bbih.2022.100461_bib5","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1038\/nature10600","article-title":"Clearance of p16 Ink4a-positive senescent cells delays ageing-associated disorders","volume":"479","author":"Baker","year":"2011","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbih.2022.100461_bib6","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3000599","article-title":"A\u00a0proteomic atlas of senescence-associated secretomes for aging biomarker development","volume":"18","author":"Basisty","year":"2020","journal-title":"PLoS Biol."},{"issue":"14","key":"10.1016\/j.bbih.2022.100461_bib7","doi-asserted-by":"crossref","first-page":"1611","DOI":"10.2174\/1381612043384664","article-title":"Oxygen, reactive oxygen species and tissue damage","volume":"10","author":"Bergamini","year":"2005","journal-title":"Curr. Pharmaceut. Des."},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib8","doi-asserted-by":"crossref","first-page":"1920","DOI":"10.1073\/pnas.0438019100","article-title":"A\u00a0mechanism converting psychosocial stress into mononuclear cell activation","volume":"100","author":"Bierhaus","year":"2003","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"12","key":"10.1016\/j.bbih.2022.100461_bib9","doi-asserted-by":"crossref","first-page":"1701","DOI":"10.1038\/mp.2016.144","article-title":"Nrf2-dependent persistent oxidative stress results in stress-induced vulnerability to depression","volume":"22","author":"Bouvier","year":"2017","journal-title":"Mol. Psychiatr."},{"issue":"9","key":"10.1016\/j.bbih.2022.100461_bib10","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1038\/nrm2233","article-title":"Cellular senescence: when bad things happen to good cells","volume":"8","author":"Campisi","year":"2007","journal-title":"Nat. Rev. Mol. Cell Biol."},{"issue":"16","key":"10.1016\/j.bbih.2022.100461_bib11","doi-asserted-by":"crossref","first-page":"5995","DOI":"10.1073\/pnas.1118355109","article-title":"Chronic stress, glucocorticoid receptor resistance, inflammation, and disease risk","volume":"109","author":"Cohen","year":"2012","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"7","key":"10.1016\/j.bbih.2022.100461_bib12","doi-asserted-by":"crossref","first-page":"1049","DOI":"10.1016\/j.bbi.2008.02.006","article-title":"Social regulation of leukocyte homeostasis: the role of glucocorticoid sensitivity","volume":"22","author":"Cole","year":"2008","journal-title":"Brain Behav. Immun."},{"issue":"8","key":"10.1016\/j.bbih.2022.100461_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pgen.1004601","article-title":"Human social Genomics","volume":"10","author":"Cole","year":"2014","journal-title":"PLoS Genet."},{"issue":"6","key":"10.1016\/j.bbih.2022.100461_bib14","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1093\/bioinformatics\/bti038","article-title":"Expression-based monitoring of transcription factor activity: the TELiS database","volume":"21","author":"Cole","year":"2005","journal-title":"Bioinformatics"},{"issue":"9","key":"10.1016\/j.bbih.2022.100461_bib15","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/gb-2007-8-9-r189","article-title":"Social regulation of gene expression in human leukocytes","volume":"8","author":"Cole","year":"2007","journal-title":"Genome Biol."},{"issue":"2","key":"10.1016\/j.bbih.2022.100461_bib16","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/j.cell.2007.07.003","article-title":"Cellular senescence in cancer and aging","volume":"130","author":"Collado","year":"2007","journal-title":"Cell"},{"issue":"3","key":"10.1016\/j.bbih.2022.100461_bib17","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41419-018-0300-z","article-title":"Transcriptional repression of DNA repair genes is a hallmark and a cause of cellular senescence article","volume":"9","author":"Collin","year":"2018","journal-title":"Cell Death Dis."},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib19","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1016\/j.pnpbp.2010.03.004","article-title":"DNA brain damage after stress in rats","volume":"34","author":"Consiglio","year":"2010","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2022.100461_bib20","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1146\/annurev-pathol-121808-102144","article-title":"The senescence-associated secretory phenotype: the dark side of tumor suppression","volume":"5","author":"Copp\u00e9","year":"2010","journal-title":"Annu. Rev. Pathol."},{"issue":"2","key":"10.1016\/j.bbih.2022.100461_bib21","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1158\/2159-8290.CD-16-0241","article-title":"Cellular senescence promotes adverse effects of chemotherapy and cancer relapse","volume":"7","author":"Demaria","year":"2017","journal-title":"Cancer Discov."},{"issue":"2","key":"10.1016\/j.bbih.2022.100461_bib22","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/0306-4530(94)90005-1","article-title":"Induction of plasma interleukin-6 by circulating adrenaline in the rat","volume":"19","author":"DeRijk","year":"1994","journal-title":"Psychoneuroendocrinology"},{"issue":"27","key":"10.1016\/j.bbih.2022.100461_bib23","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.0105-2896.2005.00259.x","article-title":"The role of CD8+ T-cell replicative senescence in human aging","volume":"205","author":"Effros","year":"2005","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.bbih.2022.100461_bib24","doi-asserted-by":"crossref","first-page":"7","DOI":"10.14310\/horm.2002.1217","article-title":"Psychological and metabolic stress: a recipe for accelerated cellular aging?","volume":"8","author":"Epel","year":"2009","journal-title":"Hormones (Basel)"},{"key":"10.1016\/j.bbih.2022.100461_bib25","series-title":"Psychoneuroimmunology","first-page":"27","article-title":"Innervation of lymphoid tissue","author":"Felten","year":"1991"},{"issue":"9","key":"10.1016\/j.bbih.2022.100461_bib26","doi-asserted-by":"crossref","first-page":"1142","DOI":"10.1016\/j.psyneuen.2004.01.007","article-title":"Cat exposure induces both intra- and extracellular Hsp72: the role of adrenal hormones","volume":"29","author":"Fleshner","year":"2004","journal-title":"Psychoneuroendocrinology"},{"issue":"1\u20132","key":"10.1016\/j.bbih.2022.100461_bib27","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jneuroim.2005.06.012","article-title":"Genomic profiling of restraint stress-induced alterations in mouse T lymphocytes","volume":"167","author":"Flint","year":"2005","journal-title":"J.\u00a0Neuroimmunol."},{"key":"10.1016\/j.bbih.2022.100461_bib28","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.mrgentox.2014.12.003","article-title":"Dynamic regulation of cerebral DNA repair genes by psychological stress","volume":"778","author":"Forsberg","year":"2015","journal-title":"Mutat. Res. Genet. Toxicol. Environ. Mutagen"},{"issue":"S1","key":"10.1016\/j.bbih.2022.100461_bib29","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1093\/gerona\/glu057","article-title":"Chronic inflammation (Inflammaging) and its potential contribution to age-associated diseases","volume":"69","author":"Franceschi","year":"2014","journal-title":"Journals Gerontol - Ser A Biol Sci Med Sci."},{"issue":"5\u20136","key":"10.1016\/j.bbih.2022.100461_bib30","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1007\/s11357-018-0047-6","article-title":"Nrf2 deficiency in aged mice exacerbates cellular senescence promoting cerebrovascular inflammation","volume":"40","author":"Fulop","year":"2018","journal-title":"GeroScience"},{"issue":"2","key":"10.1016\/j.bbih.2022.100461_bib31","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/j.mbs.2012.12.007","article-title":"Statistical properties of the quantile normalization method for density curve alignment","volume":"242","author":"Gall\u00f3n","year":"2013","journal-title":"Math. Biosci."},{"issue":"3","key":"10.1016\/j.bbih.2022.100461_bib32","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.biopsycho.2005.11.011","article-title":"The relation between psychological factors and DNA-damage: a critical review","volume":"72","author":"Gidron","year":"2006","journal-title":"Biol. Psychol."},{"issue":"3","key":"10.1016\/j.bbih.2022.100461_bib33","doi-asserted-by":"crossref","first-page":"859","DOI":"10.1128\/MCB.16.3.859","article-title":"Regulation of p16CDKN2 expression and its implications for cell immortalization and senescence","volume":"16","author":"Hara","year":"1996","journal-title":"Mol. Cell Biol."},{"issue":"2","key":"10.1016\/j.bbih.2022.100461_bib34","doi-asserted-by":"crossref","first-page":"219","DOI":"10.4161\/cc.23368","article-title":"Pharmacological blockade of a \u03b22AR-\u03b2-arrestin-1 signaling cascade prevents the accumulation of DNA damage in a behavioral stress model","volume":"12","author":"Hara","year":"2013","journal-title":"Cell Cycle"},{"issue":"7","key":"10.1016\/j.bbih.2022.100461_bib35","doi-asserted-by":"crossref","first-page":"754","DOI":"10.1038\/nm.3589","article-title":"Chronic variable stress activates hematopoietic stem cells","volume":"20","author":"Heidt","year":"2014","journal-title":"Nat. Med."},{"issue":"2","key":"10.1016\/j.bbih.2022.100461_bib36","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/0165-5728(94)90027-2","article-title":"Stress-induced changes attributable to the sympathetic nervous system during experimental influenza viral infection in DBA\/2 inbred mouse strain","volume":"53","author":"Hermann","year":"1994","journal-title":"J.\u00a0Neuroimmunol."},{"issue":"9","key":"10.1016\/j.bbih.2022.100461_bib37","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1038\/nri3042","article-title":"Reciprocal regulation of the neural and innate immune systems","volume":"11","author":"Irwin","year":"2011","journal-title":"Nat. Rev. Immunol."},{"issue":"5","key":"10.1016\/j.bbih.2022.100461_bib38","doi-asserted-by":"crossref","first-page":"1789","DOI":"10.1152\/japplphysiol.00390.2005","article-title":"Adrenergic receptors mediate stress-induced elevations in extracellular Hsp72","volume":"99","author":"Johnson","year":"2005","journal-title":"J.\u00a0Appl. Physiol."},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib39","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1536\/ihj.17-313","article-title":"Catecholamine-induced senescence of endothelial cells and bone marrow cells promotes cardiac dysfunction in mice","volume":"59","author":"Katsuumi","year":"2018","journal-title":"Int. Heart J."},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib40","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1111\/j.1474-9726.2012.00827.x","article-title":"The heat shock transcription factor Hsf1 is downregulated in DNA damage-associated senescence, contributing to the maintenance of senescence phenotype","volume":"11","author":"Kim","year":"2012","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbih.2022.100461_bib41","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.ebiom.2017.04.013","article-title":"Cellular senescence: a translational perspective","volume":"21","author":"Kirkland","year":"2017","journal-title":"EBioMedicine"},{"issue":"1","key":"10.1016\/j.bbih.2022.100461_bib42","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1751-9861.2008.00025.x","article-title":"Psychological stress and oxidative damage in lymphocytes of aerobically fit and unfit individuals","volume":"13","author":"Knickelbein","year":"2008","journal-title":"J.\u00a0Appl. Biobehav. Res."},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib43","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1016\/j.bbi.2012.01.013","article-title":"Chronic stress enhances progression of acute lymphoblastic leukemia via \u03b2-adrenergic signaling","volume":"26","author":"Lamkin","year":"2012","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2022.100461_bib44","series-title":"Transcriptional Repression of the D-type Cyclin-dependent Kinase Inhibitor Pl6 by the Retinoblastoma Susceptibility Gene Product pRb","author":"Li","year":"1994"},{"issue":"1","key":"10.1016\/j.bbih.2022.100461_bib45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.2174\/156720208783565654","article-title":"Repeated restraint and nerve growth factor Administration in male and female mice: effect on sympathetic and cardiovascular mediators of the stress response","volume":"5","author":"Manni","year":"2008","journal-title":"Curr. Neurovascular Res."},{"issue":"2","key":"10.1016\/j.bbih.2022.100461_bib46","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1080\/10253890.2018.1542683","article-title":"Hypertension linked to allostatic load: from psychosocial stress to inflammation and mitochondrial dysfunction","volume":"22","author":"Mar\u00f3n","year":"2019","journal-title":"Stress"},{"issue":"2","key":"10.1016\/j.bbih.2022.100461_bib47","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1038\/sj.leu.2401303","article-title":"Enhanced expression of p16(ink4a) is associated with a poor prognosis in childhood acute lymphoblastic leukemia","volume":"13","author":"Mekki","year":"1999","journal-title":"Leukemia"},{"issue":"6","key":"10.1016\/j.bbih.2022.100461_bib48","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1037\/0278-6133.21.6.531","article-title":"Chronic psychological stress and the regulation of pro-inflammatory cytokines: a glucocorticoid-resistance model","volume":"21","author":"Miller","year":"2002","journal-title":"Health Psychol."},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib49","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.biopsych.2008.03.017","article-title":"A\u00a0functional genomic fingerprint of chronic stress in humans: blunted glucocorticoid and increased NF-\u03baB signaling","volume":"64","author":"Miller","year":"2008","journal-title":"Biol. Psychiatr."},{"issue":"1","key":"10.1016\/j.bbih.2022.100461_bib50","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.bbi.2014.05.016","article-title":"Greater inflammatory activity and blunted glucocorticoid signaling in monocytes of chronically stressed caregivers","volume":"41","author":"Miller","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.bbih.2022.100461_bib51","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1016\/j.bbi.2007.03.008","article-title":"Autonomic innervation and regulation of the immune system (1987-2007)","volume":"21","author":"Nance","year":"2007","journal-title":"Brain Behav. Immun."},{"issue":"9","key":"10.1016\/j.bbih.2022.100461_bib52","doi-asserted-by":"crossref","first-page":"2328","DOI":"10.1523\/JNEUROSCI.2568-17.2018","article-title":"Corticosterone production during repeated social defeat causes monocyte mobilization from the bone marrow, glucocorticoid resistance, and neurovascular adhesion molecule expression","volume":"38","author":"Niraula","year":"2018","journal-title":"J.\u00a0Neurosci."},{"key":"10.1016\/j.bbih.2022.100461_bib53","volume":"vol. 29","author":"Nishio","year":"2007"},{"issue":"7","key":"10.1016\/j.bbih.2022.100461_bib54","doi-asserted-by":"crossref","first-page":"1316","DOI":"10.18632\/aging.100971","article-title":"Unbiased analysis of senescence associated secretory phenotype (SASP) to identify common components following different genotoxic stresses","volume":"8","author":"\u00d6zcan","year":"2016","journal-title":"Aging (Albany NY)"},{"issue":"9","key":"10.1016\/j.bbih.2022.100461_bib55","doi-asserted-by":"crossref","DOI":"10.1242\/jcs.210724","article-title":"Acute HSF1 depletion induces cellular senescence through the MDM2-p53-p21 pathway in human diploid fibroblasts","volume":"131","author":"Oda","year":"2018","journal-title":"J.\u00a0Cell Sci."},{"issue":"41","key":"10.1016\/j.bbih.2022.100461_bib56","doi-asserted-by":"crossref","first-page":"16574","DOI":"10.1073\/pnas.1310655110","article-title":"Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via -adrenergic induction of myelopoiesis","volume":"110","author":"Powell","year":"2013","journal-title":"Proc. Natl. Acad. Sci. Unit. States Am."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2022.100461_bib57","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1016\/S0165-5728(03)00042-0","article-title":"Molecular mechanisms of glucocorticoid resistance in splenocytes of socially stressed male mice","volume":"137","author":"Quan","year":"2003","journal-title":"J.\u00a0Neuroimmunol."},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib58","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12778","article-title":"Social stress shortens lifespan in mice","volume":"17","author":"Razzoli","year":"2018","journal-title":"Aging Cell"},{"issue":"2","key":"10.1016\/j.bbih.2022.100461_bib59","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1210\/en.2006-0983","article-title":"Adrenal insufficiency and colonic inflammation after a novel chronic psycho-social stress paradigm in mice: implications and mechanisms","volume":"148","author":"Reber","year":"2007","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbih.2022.100461_bib60","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2018.12.006","article-title":"Chronic stress exposure and daily stress appraisals relate to biological aging marker p16 INK4a","volume":"102","author":"Rentscher","year":"2019","journal-title":"Psychoneuroendocrinology"},{"issue":"8","key":"10.1016\/j.bbih.2022.100461_bib61","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1111\/j.1751-9004.2011.00368.x","article-title":"Restorative biological processes and health","volume":"5","author":"Robles","year":"2011","journal-title":"Soc Personal Psychol Compass"},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib62","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1083\/jcb.201009094","article-title":"Four faces of cellular senescence","volume":"192","author":"Rodier","year":"2011","journal-title":"J.\u00a0Cell Biol."},{"issue":"18","key":"10.1016\/j.bbih.2022.100461_bib63","doi-asserted-by":"crossref","first-page":"2909","DOI":"10.1200\/JCO.2008.18.7435","article-title":"Biologic cost of caring for a cancer patient: dysregulation of pro- and anti-inflammatory signaling pathways","volume":"27","author":"Rohleder","year":"2009","journal-title":"J.\u00a0Clin. Oncol."},{"issue":"4","key":"10.1016\/j.bbih.2022.100461_bib64","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1667\/RR14862.1","article-title":"Global gene expression response in mouse models of DNA repair deficiency after gamma irradiation","volume":"189","author":"Rudqvist","year":"2018","journal-title":"Radiat. Res."},{"issue":"7","key":"10.1016\/j.bbih.2022.100461_bib65","doi-asserted-by":"crossref","first-page":"1097","DOI":"10.1016\/j.bbi.2010.04.014","article-title":"Chronic psychosocial stress promotes systemic immune activation and the development of inflammatory Th cell responses","volume":"24","author":"Schmidt","year":"2010","journal-title":"Brain Behav. Immun."},{"issue":"9","key":"10.1016\/j.bbih.2022.100461_bib66","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1016\/j.psyneuen.2013.03.010","article-title":"Stress and telomere biology: a lifespan perspective","volume":"38","author":"Shalev","year":"2013","journal-title":"Psychoneuroendocrinology"},{"issue":"11","key":"10.1016\/j.bbih.2022.100461_bib67","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.3109\/10715762.2010.507670","article-title":"Nrf2-ARE stress response mechanism: a control point in oxidative stress-mediated dysfunctions and chronic inflammatory diseases","volume":"44","author":"Singh","year":"2010","journal-title":"Free Radic. Res."},{"issue":"1","key":"10.1016\/j.bbih.2022.100461_bib68","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.bbi.2007.06.011","article-title":"Stress-induced remodeling of lymphoid innervation","volume":"22","author":"Sloan","year":"2008","journal-title":"Brain Behav. Immun."},{"issue":"5 45\u20135","key":"10.1016\/j.bbih.2022.100461_bib69","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1152\/ajpregu.1999.276.5.R1461","article-title":"Prevention of stress-induced weight loss by third ventricle CRF receptor antagonist","volume":"276","author":"Smagin","year":"1999","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"6 49\u20136","key":"10.1016\/j.bbih.2022.100461_bib70","article-title":"Social stress induces glucocorticoid resistance in macrophages","volume":"280","author":"Stark","year":"2001","journal-title":"Am. J. Physiol. Regul. Integr. Comp. Physiol."},{"issue":"8","key":"10.1016\/j.bbih.2022.100461_bib71","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/nm1447","article-title":"Chronic stress promotes tumor growth and angiogenesis in a mouse model of ovarian carcinoma","volume":"12","author":"Thaker","year":"2006","journal-title":"Nat. Med."},{"issue":"5","key":"10.1016\/j.bbih.2022.100461_bib72","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.tem.2008.12.005","article-title":"Hsps and aging","volume":"20","author":"Tower","year":"2009","journal-title":"Trends Endocrinol. Metabol."},{"key":"10.1016\/j.bbih.2022.100461_bib73","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.bbi.2017.12.011","article-title":"Development of glucocorticoid resistance over one year among mothers of children newly diagnosed with cancer","volume":"69","author":"Walsh","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2022.100461_bib74","article-title":"Modern statistics for the social and behavioral sciences","author":"Wilcox","year":"2017","journal-title":"Mod Stat Soc Behav Sci"},{"key":"10.1016\/j.bbih.2022.100461_bib75","doi-asserted-by":"crossref","DOI":"10.1038\/s41586-021-03547-7","article-title":"An aged immune system drives senescence and ageing of solid organs","author":"Yousefzadeh","year":"2021","journal-title":"Nature"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354622000515?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354622000515?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:25:47Z","timestamp":1762986347000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354622000515"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7]]},"references-count":74,"alternative-id":["S2666354622000515"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2022.100461","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2022,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronic stress increases transcriptomic indicators of biological aging in mouse bone marrow leukocytes","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2022.100461","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2022 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100461"}}