{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,29]],"date-time":"2026-06-29T09:40:40Z","timestamp":1782726040998,"version":"3.54.5"},"reference-count":59,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,2,1]],"date-time":"2023-02-01T00:00:00Z","timestamp":1675209600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2022,12,23]],"date-time":"2022-12-23T00:00:00Z","timestamp":1671753600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000874","name":"Brain and Behavior Research Foundation","doi-asserted-by":"publisher","award":["18740"],"award-info":[{"award-number":["18740"]}],"id":[{"id":"10.13039\/100000874","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000925","name":"National Health and Medical Research Council","doi-asserted-by":"publisher","award":["1156072"],"award-info":[{"award-number":["1156072"]}],"id":[{"id":"10.13039\/501100000925","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001778","name":"Deakin University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100001778","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2023,2]]},"DOI":"10.1016\/j.bbih.2022.100581","type":"journal-article","created":{"date-parts":[[2022,12,24]],"date-time":"2022-12-24T12:26:28Z","timestamp":1671884788000},"page":"100581","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response"],"prefix":"10.1016","volume":"27","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5399-1245","authenticated-orcid":false,"given":"Adam J.","family":"Walker","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mohammadreza","family":"Mohebbi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Maes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ken","family":"Walder","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chiara C.","family":"Bortolasci","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zoe SJ.","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chee H.","family":"Ng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie M.","family":"Ashton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3677-7503","authenticated-orcid":false,"given":"Lesley","family":"Berk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajeet B.","family":"Singh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gin S.","family":"Malhi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olivia M.","family":"Dean","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2022.100581_bib1","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1136\/jnnp-2019-320912","article-title":"Efficacy and safety of anti-inflammatory agents for the treatment of major depressive disorder: a systematic review and meta-analysis of randomised controlled trials","volume":"91","author":"Bai","year":"2020","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbih.2022.100581_bib2","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1159\/000513093","article-title":"Association of chemokine (C-C motif) receptor 5 and ligand 5 with recovery from major depressive disorder and related neurocognitive impairment","volume":"27","author":"Bauer","year":"2020","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.bbih.2022.100581_bib3","doi-asserted-by":"crossref","first-page":"529","DOI":"10.1016\/S0022-3999(97)00139-6","article-title":"Acute phase proteins in major depression","volume":"43","author":"Berk","year":"1997","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.bbih.2022.100581_bib4","doi-asserted-by":"crossref","first-page":"779","DOI":"10.1001\/jamapsychiatry.2019.0673","article-title":"Biomarker-guided anti-inflammatory therapies: from promise to reality check","volume":"76","author":"Berk","year":"2019","journal-title":"JAMA Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib5","first-page":"1334","article-title":"Expression and activity of metalloproteinases in depression","volume":"22","author":"Bobinska","year":"2016","journal-title":"Med. Sci. Mon. Int. Med. J. Exp. Clin. Res."},{"key":"10.1016\/j.bbih.2022.100581_bib6","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1007\/s11126-019-09707-3","article-title":"Minocycline for depressive symptoms: a meta-analysis of randomized, double-blinded, placebo-controlled trials","volume":"91","author":"Cai","year":"2020","journal-title":"Psychiatr. Q."},{"key":"10.1016\/j.bbih.2022.100581_bib7","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.biopsych.2021.05.008","article-title":"Brain-Derived neurotrophic factor signaling in depression and antidepressant action","volume":"90","author":"Castren","year":"2021","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib8","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1016\/j.jpsychires.2016.08.020","article-title":"Blood-based immune-endocrine biomarkers of treatment response in depression","volume":"83","author":"Chan","year":"2016","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbih.2022.100581_bib9","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1016\/j.immuni.2010.07.018","article-title":"Lipid-cytokine-chemokine cascade drives neutrophil recruitment in a murine model of inflammatory arthritis","volume":"33","author":"Chou","year":"2010","journal-title":"Immunity"},{"key":"10.1016\/j.bbih.2022.100581_bib10","doi-asserted-by":"crossref","first-page":"391","DOI":"10.2165\/11632000-000000000-00000","article-title":"Minocycline: therapeutic potential in psychiatry","volume":"26","author":"Dean","year":"2012","journal-title":"CNS Drugs"},{"key":"10.1016\/j.bbih.2022.100581_bib11","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1177\/0004867417709357","article-title":"Adjunctive minocycline treatment for major depressive disorder: a proof of concept trial","volume":"51","author":"Dean","year":"2017","journal-title":"Aust. N. Z. J. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib12","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.euroneuro.2022.10.003","article-title":"Current approaches to precision medicine in psychiatry: are we just spinning our wheels?","volume":"66","author":"Dean","year":"2022","journal-title":"Eur. Neuropsychopharmacol"},{"key":"10.1016\/j.bbih.2022.100581_bib13","doi-asserted-by":"crossref","first-page":"2095","DOI":"10.1182\/blood.V87.6.2095.bloodjournal8762095","article-title":"Biologic basis for interleukin-1 in disease","volume":"87","author":"Dinarello","year":"1996","journal-title":"Blood"},{"key":"10.1016\/j.bbih.2022.100581_bib14","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1038\/s41380-018-0096-3","article-title":"What does plasma CRP tell us about peripheral and central inflammation in depression?","volume":"25","author":"Felger","year":"2020","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib15","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1016\/j.biopsych.2020.04.024","article-title":"Identifying immunophenotypes of inflammation in depression: dismantling the monolith","volume":"88","author":"Felger","year":"2020","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib16","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.3389\/fimmu.2019.01412","article-title":"Structural basis of IL-1 family cytokine signaling","volume":"10","author":"Fields","year":"2019","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2022.100581_bib17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/bph.12139","article-title":"Minocycline: far beyond an antibiotic","volume":"169","author":"Garrido-Mesa","year":"2013","journal-title":"Br. J. Pharmacol."},{"key":"10.1016\/j.bbih.2022.100581_bib18","doi-asserted-by":"crossref","first-page":"1696","DOI":"10.1038\/mp.2016.3","article-title":"A meta-analysis of blood cytokine network alterations in psychiatric patients: comparisons between schizophrenia, bipolar disorder and depression","volume":"21","author":"Goldsmith","year":"2016","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib19","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1007\/s00213-015-3943-9","article-title":"Circulating cytotoxic T cells and natural killer cells as potential predictors for antidepressant response in melancholic depression. Restoration of T regulatory cell populations after antidepressant therapy","volume":"233","author":"Grosse","year":"2016","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbih.2022.100581_bib20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1017\/neu.2021.44","article-title":"Exploring interleukin-6, lipopolysaccharide-binding protein and brain-derived neurotrophic factor following 12 weeks of adjunctive minocycline treatment for depression","volume":"34","author":"Hasebe","year":"2022","journal-title":"Acta Neuropsychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib21","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/S2215-0366(20)30138-3","article-title":"Minocycline and celecoxib as adjunctive treatments for bipolar depression: a multicentre, factorial design randomised controlled trial","volume":"7","author":"Husain","year":"2020","journal-title":"Lancet Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib22","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/PSY.0b013e3181dbf489","article-title":"Stress, food, and inflammation: psychoneuroimmunology and nutrition at the cutting edge","volume":"72","author":"Kiecolt-Glaser","year":"2010","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbih.2022.100581_bib23","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1111\/acps.12698","article-title":"Peripheral cytokine and chemokine alterations in depression: a meta-analysis of 82 studies","volume":"135","author":"Kohler","year":"2017","journal-title":"Acta Psychiatr. Scand."},{"key":"10.1016\/j.bbih.2022.100581_bib24","first-page":"4195","article-title":"Peripheral alterations in cytokine and chemokine levels after antidepressant drug treatment for major depressive disorder: systematic review and meta-analysis","volume":"55","author":"Kohler","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbih.2022.100581_bib25","doi-asserted-by":"crossref","first-page":"877","DOI":"10.1001\/archpsyc.59.10.877","article-title":"Mediators and moderators of treatment effects in randomized clinical trials","volume":"59","author":"Kraemer","year":"2002","journal-title":"Arch. Gen. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib26","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1038\/mp.2017.205","article-title":"Chemokines in depression in health and in inflammatory illness: a systematic review and meta-analysis","volume":"23","author":"Leighton","year":"2018","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib27","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1038\/s41380-019-0474-5","article-title":"Peripheral cytokine levels and response to antidepressant treatment in depression: a systematic review and meta-analysis","volume":"25","author":"Liu","year":"2020","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib28","doi-asserted-by":"crossref","first-page":"741","DOI":"10.1186\/s12888-022-04410-3","article-title":"Plasma complement C3 and C3a are increased in major depressive disorder independent of childhood trauma","volume":"22","author":"Luo","year":"2022","journal-title":"BMC Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib29","doi-asserted-by":"crossref","first-page":"401","DOI":"10.1016\/j.jpsychires.2021.03.010","article-title":"Comparison of inflammatory, nutrient, and neurohormonal indicators in patients with schizophrenia, bipolar disorder and major depressive disorder","volume":"137","author":"Lyu","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbih.2022.100581_bib30","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1006\/cyto.1997.0238","article-title":"Increased serum IL-6 and IL-1 receptor antagonist concentrations in major depression and treatment resistant depression","volume":"9","author":"Maes","year":"1997","journal-title":"Cytokine"},{"key":"10.1016\/j.bbih.2022.100581_bib31","doi-asserted-by":"crossref","first-page":"8885","DOI":"10.1007\/s12035-018-1016-x","article-title":"The compensatory immune-regulatory reflex system (CIRS) in depression and bipolar disorder","volume":"55","author":"Maes","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbih.2022.100581_bib32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0165-1781(96)02915-0","article-title":"Acute phase proteins in schizophrenia, mania and major depression: modulation by psychotropic drugs","volume":"66","author":"Maes","year":"1997","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.bbih.2022.100581_bib33","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/0278-5846(94)90079-5","article-title":"Natural killer cell activity in major depression: relation to circulating natural killer cells, cellular indices of the immune response, and depressive phenomenology","volume":"18","author":"Maes","year":"1994","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbih.2022.100581_bib34","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/0165-0327(96)00038-9","article-title":"Alterations in iron metabolism and the erythron in major depression: further evidence for a chronic inflammatory process","volume":"40","author":"Maes","year":"1996","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbih.2022.100581_bib35","doi-asserted-by":"crossref","first-page":"4158","DOI":"10.1038\/s41380-020-00951-9","article-title":"The kynurenine pathway in major depressive disorder, bipolar disorder, and schizophrenia: a meta-analysis of 101 studies","volume":"26","author":"Marx","year":"2021","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib36","doi-asserted-by":"crossref","first-page":"4926","DOI":"10.1007\/s12035-022-02889-1","article-title":"Interactions among brain-derived neurotrophic factor and neuroimmune pathways are key components of the major psychiatric disorders","volume":"59","author":"Mehterov","year":"2022","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbih.2022.100581_bib37","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1038\/npp.2016.90","article-title":"Immune and neuroendocrine mechanisms of stress vulnerability and resilience","volume":"42","author":"Menard","year":"2017","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbih.2022.100581_bib38","doi-asserted-by":"crossref","DOI":"10.1016\/j.psychres.2022.114857","article-title":"Brain-Derived Neurotrophic Factor (BDNF) as a biomarker of treatment response in patients with Treatment Resistant Depression (TRD): a systematic review & meta-analysis","volume":"317","author":"Meshkat","year":"2022","journal-title":"Psychiatr. Res."},{"key":"10.1016\/j.bbih.2022.100581_bib39","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1016\/j.biopsych.2020.01.014","article-title":"Depression heterogeneity and its biological underpinnings: toward immunometabolic depression","volume":"88","author":"Milaneschi","year":"2020","journal-title":"Biol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib40","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S2215-0366(20)30357-6","article-title":"Trial failures of anti-inflammatory drugs in depression","volume":"7","author":"Miller","year":"2020","journal-title":"Lancet Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib41","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1177\/0004867418796955","article-title":"Leaky brain in neurological and psychiatric disorders: drivers and consequences","volume":"52","author":"Morris","year":"2018","journal-title":"Aust. N. Z. J. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib42","doi-asserted-by":"crossref","first-page":"5767","DOI":"10.1007\/s12035-017-0793-y","article-title":"Cell death pathways: a novel therapeutic approach for neuroscientists","volume":"55","author":"Morris","year":"2018","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbih.2022.100581_bib43","doi-asserted-by":"crossref","first-page":"1251","DOI":"10.3389\/fphar.2019.01251","article-title":"The role of intercellular adhesion molecule-1 in the pathogenesis of psychiatric disorders","volume":"10","author":"Muller","year":"2019","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbih.2022.100581_bib44","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1038\/s41386-020-00948-6","article-title":"Augmentation therapy with minocycline in treatment-resistant depression patients with low-grade peripheral inflammation: results from a double-blind randomised clinical trial","volume":"46","author":"Nettis","year":"2021","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbih.2022.100581_bib45","doi-asserted-by":"crossref","first-page":"1958","DOI":"10.1017\/S0033291719001454","article-title":"Prevalence of low-grade inflammation in depression: a systematic review and meta-analysis of CRP levels","volume":"49","author":"Osimo","year":"2019","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbih.2022.100581_bib46","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1038\/s41398-021-01481-w","article-title":"Toll-like receptor 4 methylation grade is linked to depressive symptom severity","volume":"11","author":"Rasmusson","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbih.2022.100581_bib47","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1038\/s41598-018-36507-9","article-title":"The antidepressant impact of minocycline in rodents: a systematic review and meta-analysis","volume":"9","author":"Reis","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2022.100581_bib48","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jad.2017.10.042","article-title":"Efficacy and tolerability of minocycline for depression: a systematic review and meta-analysis of clinical trials","volume":"227","author":"Rosenblat","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbih.2022.100581_bib49","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/s41398-017-0073-7","article-title":"Treatment of bipolar depression with minocycline and\/or aspirin: an adaptive, 2x2 double-blind, randomized, placebo-controlled, phase IIA clinical trial","volume":"8","author":"Savitz","year":"2018","journal-title":"Transl. Psychiatry"},{"issue":"Suppl. 20","key":"10.1016\/j.bbih.2022.100581_bib50","first-page":"22","article-title":"The Mini-International Neuropsychiatric Interview (M.I.N.I.): the development and validation of a structured diagnostic psychiatric interview for DSM-IV and ICD-10","volume":"59","author":"Sheehan","year":"1998","journal-title":"J. Clin. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib51","series-title":"Inflammasomes Action as an Important Mechanism in Experimental and Clinical Depression. Inflammation and Immunity in Depression","first-page":"161","author":"Singhal","year":"2018"},{"key":"10.1016\/j.bbih.2022.100581_bib52","doi-asserted-by":"crossref","first-page":"1271","DOI":"10.3389\/fpsyg.2020.01271","article-title":"Changes of serum melatonin, interleukin-6, homocysteine, and complement C3 and C4 levels in patients with depression","volume":"11","author":"Tao","year":"2020","journal-title":"Front. Psychol."},{"key":"10.1016\/j.bbih.2022.100581_bib53","doi-asserted-by":"crossref","DOI":"10.1016\/j.pnpbp.2020.110173","article-title":"Role of interleukin 8 in depression and other psychiatric disorders","volume":"106","author":"Tsai","year":"2021","journal-title":"Prog. Neuro-Psychopharmacol. Biol. Psychiatry"},{"key":"10.1016\/j.bbih.2022.100581_bib54","doi-asserted-by":"crossref","first-page":"61","DOI":"10.2174\/1574887112666171128134552","article-title":"The emerging role of complement C3 as A biomarker of insulin resistance and cardiometabolic diseases: preclinical and clinical evidence","volume":"13","author":"Ursini","year":"2018","journal-title":"Rev. Recent Clin. Trials"},{"key":"10.1016\/j.bbih.2022.100581_bib55","doi-asserted-by":"crossref","first-page":"729","DOI":"10.1001\/jamapsychiatry.2017.0984","article-title":"Association of microvascular dysfunction with late-life depression: a systematic review and meta-analysis","volume":"74","author":"van Agtmaal","year":"2017","journal-title":"JAMA Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib56","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/mp.2016.46","article-title":"Inflammasome signaling affects anxiety- and depressive-like behavior and gut microbiome composition","volume":"21","author":"Wong","year":"2016","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib57","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1152\/physiol.00029.2013","article-title":"Matrix metalloproteinase-9: many shades of function in cardiovascular disease","volume":"28","author":"Yabluchanskiy","year":"2013","journal-title":"Physiology"},{"key":"10.1016\/j.bbih.2022.100581_bib58","doi-asserted-by":"crossref","first-page":"784","DOI":"10.1177\/0004867420965697","article-title":"Minocycline as adjunctive treatment for major depressive disorder: pooled data from two randomized controlled trials","volume":"55","author":"Zazula","year":"2021","journal-title":"Aust. N. Z. J. Psychiatr."},{"key":"10.1016\/j.bbih.2022.100581_bib59","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1016\/j.jad.2015.09.074","article-title":"The association between serum ferritin levels and post-stroke depression","volume":"190","author":"Zhu","year":"2016","journal-title":"J. Affect. Disord."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354622001715?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354622001715?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:27:12Z","timestamp":1762986432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354622001715"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,2]]},"references-count":59,"alternative-id":["S2666354622001715"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2022.100581","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2023,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Adjunctive minocycline for major depressive disorder: A sub-study exploring peripheral immune-inflammatory markers and associated treatment response","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2022.100581","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100581"}}