{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T06:23:59Z","timestamp":1792045439275,"version":"4.4.0"},"reference-count":65,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,7,1]],"date-time":"2023-07-01T00:00:00Z","timestamp":1688169600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,4,7]],"date-time":"2023-04-07T00:00:00Z","timestamp":1680825600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100008665","name":"Osaka Medical Research Foundation for Intractable Diseases","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100008665","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007683","name":"Nihon University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007683","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007854","name":"Nihon University School of Dentistry Graduate School of Dentistry","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100007854","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000646","name":"Japan Society for the Promotion of Science","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100000646","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2023,7]]},"DOI":"10.1016\/j.bbih.2023.100622","type":"journal-article","created":{"date-parts":[[2023,4,8]],"date-time":"2023-04-08T11:15:15Z","timestamp":1680952515000},"page":"100622","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Microglia cause structural remodeling of noradrenergic axon in the trigeminal spinal subnucleus caudalis after infraorbital nerve injury in rats"],"prefix":"10.1016","volume":"30","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7750-0674","authenticated-orcid":false,"given":"Yoshinori","family":"Hayashi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo","family":"Otsuji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eri","family":"Oshima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzuro","family":"Hitomi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junjun","family":"Ni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kentaro","family":"Urata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ikuko","family":"Shibuta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koichi","family":"Iwata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masamichi","family":"Shinoda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"12","key":"10.1016\/j.bbih.2023.100622_bib1","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1002\/glia.23880","article-title":"Exosomes derived from microglia exposed to elevated pressure amplify the neuroinflammatory response in retinal cells","volume":"68","author":"Aires","year":"2020","journal-title":"Glia"},{"issue":"4","key":"10.1016\/j.bbih.2023.100622_bib2","doi-asserted-by":"crossref","first-page":"2126","DOI":"10.4049\/jimmunol.172.4.2126","article-title":"Exosomes as potent cell-free peptide-based vaccine. I. Dendritic cell-derived exosomes transfer functional MHC class I\/peptide complexes to dendritic cells","volume":"172","author":"Andre","year":"2004","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.bbih.2023.100622_bib3","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1038\/nn.4132","article-title":"Depletion of microglia and inhibition of exosome synthesis halt tau propagation","volume":"18","author":"Asai","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"18","key":"10.1016\/j.bbih.2023.100622_bib4","doi-asserted-by":"crossref","first-page":"6834","DOI":"10.3390\/ijms21186834","article-title":"Microglia-astrocyte communication via C1q contributes to orofacial neuropathic pain associated with infraorbital nerve injury","volume":"21","author":"Asano","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"6836","key":"10.1016\/j.bbih.2023.100622_bib5","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1038\/35078099","article-title":"B cells acquire antigen from target cells after synapse formation","volume":"411","author":"Batista","year":"2001","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbih.2023.100622_bib6","doi-asserted-by":"crossref","first-page":"174","DOI":"10.1016\/j.neuroscience.2009.02.023","article-title":"Noradrenergic neurons in the locus coeruleus contribute to neuropathic pain","volume":"160","author":"Brightwell","year":"2009","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbih.2023.100622_bib7","article-title":"The neuropathic pain: an overview of the current treatment and future therapeutic approaches","volume":"332058738419838383","author":"Cavalli","year":"2019","journal-title":"Int. J. Immunopathol. Pharmacol."},{"key":"10.1016\/j.bbih.2023.100622_bib8","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms4633","article-title":"MHC-I expression renders catecholaminergic neurons susceptible to T-cell-mediated degeneration","author":"Cebrian","year":"2014","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bbih.2023.100622_bib9","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.neuron.2020.08.002","article-title":"Sensory experience engages microglia to shape neural connectivity through a non-phagocytic mechanism","volume":"108","author":"Cheadle","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.bbih.2023.100622_bib10","first-page":"193440","article-title":"Proteinase-activated receptor 2 sensitizes transient receptor potential vanilloid 1, transient receptor potential vanilloid 4, and transient receptor potential ankyrin 1 in paclitaxel-induced neuropathic pain","author":"Chen","year":"2011","journal-title":"Neuroscience"},{"issue":"46","key":"10.1016\/j.bbih.2023.100622_bib11","doi-asserted-by":"crossref","first-page":"14415","DOI":"10.1523\/JNEUROSCI.4569-09.2009","article-title":"T-cell infiltration and signaling in the adult dorsal spinal cord is a major contributor to neuropathic pain-like hypersensitivity","volume":"29","author":"Costigan","year":"2009","journal-title":"J. Neurosci."},{"issue":"7070","key":"10.1016\/j.bbih.2023.100622_bib12","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1038\/nature04223","article-title":"BDNF from microglia causes the shift in neuronal anion gradient underlying neuropathic pain","volume":"438","author":"Coull","year":"2005","journal-title":"Nature"},{"issue":"15","key":"10.1016\/j.bbih.2023.100622_bib13","doi-asserted-by":"crossref","first-page":"4048","DOI":"10.1016\/j.cell.2021.06.018","article-title":"GABA-receptive microglia selectively sculpt developing inhibitory circuits","volume":"184","author":"Favuzzi","year":"2021","journal-title":"Cell"},{"issue":"7912","key":"10.1016\/j.bbih.2023.100622_bib14","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/s41586-022-04777-z","article-title":"Neuropathic pain caused by miswiring and abnormal end organ targeting","volume":"606","author":"Gangadharan","year":"2022","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbih.2023.100622_bib15","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1038\/nn.4189","article-title":"Injured sensory neuron-derived CSF1 induces microglial proliferation and DAP12-dependent pain","volume":"19","author":"Guan","year":"2016","journal-title":"Nat. Neurosci."},{"issue":"48","key":"10.1016\/j.bbih.2023.100622_bib16","doi-asserted-by":"crossref","first-page":"17370","DOI":"10.1523\/JNEUROSCI.4152-11.2011","article-title":"Microglial Ca(2+)-activated K(+) channels are possible molecular targets for the analgesic effects of S-ketamine on neuropathic pain","volume":"31","author":"Hayashi","year":"2011","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2023.100622_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/srep02744","article-title":"The intrinsic microglial molecular clock controls synaptic strength via the circadian expression of cathepsin S","author":"Hayashi","year":"2013","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2023.100622_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms11697","article-title":"BK channels in microglia are required for morphine-induced hyperalgesia","author":"Hayashi","year":"2016","journal-title":"Nat. Commun."},{"issue":"6","key":"10.1016\/j.bbih.2023.100622_bib19","doi-asserted-by":"crossref","first-page":"1077","DOI":"10.1097\/ALN.0b013e31818dac9c","article-title":"Gabapentin acts within the locus coeruleus to alleviate neuropathic pain","volume":"109","author":"Hayashida","year":"2008","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbih.2023.100622_bib20","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.29808","article-title":"Functional dichotomy in spinal- vs prefrontal-projecting locus coeruleus modules splits descending noradrenergic analgesia from ascending aversion and anxiety in rats","volume":"6","author":"Hirschberg","year":"2017","journal-title":"Elife"},{"issue":"41","key":"10.1016\/j.bbih.2023.100622_bib21","doi-asserted-by":"crossref","first-page":"12855","DOI":"10.1523\/JNEUROSCI.1699-09.2009","article-title":"Retrograde viral vector-mediated inhibition of pontospinal noradrenergic neurons causes hyperalgesia in rats","volume":"29","author":"Howorth","year":"2009","journal-title":"J. Neurosci."},{"issue":"9","key":"10.1016\/j.bbih.2023.100622_bib22","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1016\/j.pain.2013.05.010","article-title":"Endogenous analgesic action of the pontospinal noradrenergic system spatially restricts and temporally delays the progression of neuropathic pain following tibial nerve injury","volume":"154","author":"Hughes","year":"2013","journal-title":"Pain"},{"issue":"5499","key":"10.1016\/j.bbih.2023.100622_bib23","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1126\/science.290.5499.2155","article-title":"Functional requirement for class I MHC in CNS development and plasticity","volume":"290","author":"Huh","year":"2000","journal-title":"Science"},{"issue":"9","key":"10.1016\/j.bbih.2023.100622_bib24","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1038\/ni0903-815","article-title":"What is trogocytosis and what is its purpose?","volume":"4","author":"Joly","year":"2003","journal-title":"Nat. Immunol."},{"issue":"4","key":"10.1016\/j.bbih.2023.100622_bib25","doi-asserted-by":"crossref","first-page":"1784","DOI":"10.4049\/jimmunol.130.4.1784","article-title":"Interleukin 2-mediated immune interferon (IFN-gamma) production by human T cells and T cell subsets","volume":"130","author":"Kasahara","year":"1983","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2023.100622_bib26","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/ni742","article-title":"T cells down-modulate peptide-MHC complexes on APCs in vivo","volume":"3","author":"Kedl","year":"2002","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbih.2023.100622_bib27","article-title":"Pannexin 1 role in the trigeminal ganglion in infraorbital nerve injury-induced mechanical allodynia","author":"Kurisu","year":"2022","journal-title":"Oral Dis."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2023.100622_bib28","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.pain.2005.02.009","article-title":"Minocycline attenuates mechanical allodynia and proinflammatory cytokine expression in rat models of pain facilitation","volume":"115","author":"Ledeboer","year":"2005","journal-title":"Pain"},{"issue":"50","key":"10.1016\/j.bbih.2023.100622_bib29","doi-asserted-by":"crossref","first-page":"17091","DOI":"10.1523\/JNEUROSCI.4403-10.2010","article-title":"CX3CR1 in microglia regulates brain amyloid deposition through selective protofibrillar amyloid-beta phagocytosis","volume":"30","author":"Liu","year":"2010","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2023.100622_bib30","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.neuroscience.2016.05.057","article-title":"Noradrenergic Locus Coeruleus pathways in pain modulation","volume":"338","author":"Llorca-Torralba","year":"2016","journal-title":"Neuroscience"},{"issue":"3","key":"10.1016\/j.bbih.2023.100622_bib31","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.4049\/jimmunol.0900798","article-title":"Novel MHC class I structures on exosomes","volume":"183","author":"Lynch","year":"2009","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.bbih.2023.100622_bib32","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1177\/02698811211069110","article-title":"Modulation of microglial activation by antidepressants","volume":"36","author":"Mariani","year":"2022","journal-title":"J. Psychopharmacol."},{"issue":"41","key":"10.1016\/j.bbih.2023.100622_bib33","doi-asserted-by":"crossref","first-page":"7965","DOI":"10.1523\/JNEUROSCI.0284-20.2020","article-title":"Alcohol increases exosome release from microglia to promote complement C1q-induced cellular death of proopiomelanocortin neurons in the hypothalamus in a rat model of fetal alcohol spectrum disorders","volume":"40","author":"Mukherjee","year":"2020","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbih.2023.100622_bib34","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aap7388","article-title":"MHC class I in dopaminergic neurons suppresses relapse to reward seeking","volume":"4","author":"Murakami","year":"2018","journal-title":"Sci. Adv."},{"issue":"2","key":"10.1016\/j.bbih.2023.100622_bib35","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1016\/j.neuroscience.2007.03.045","article-title":"Intrathecal administration of ATP produces long-lasting allodynia in rats: differential mechanisms in the phase of the induction and maintenance","volume":"147","author":"Nakagawa","year":"2007","journal-title":"Neuroscience"},{"issue":"12","key":"10.1016\/j.bbih.2023.100622_bib36","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1084\/jem.186.12.2023","article-title":"Interferon gamma gene expression in sensory neurons: evidence for autocrine gene regulation","volume":"186","author":"Neumann","year":"1997","journal-title":"J. Exp. Med."},{"issue":"5726","key":"10.1016\/j.bbih.2023.100622_bib37","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1126\/science.1110647","article-title":"Resting microglial cells are highly dynamic surveillants of brain parenchyma in vivo","volume":"308","author":"Nimmerjahn","year":"2005","journal-title":"Science"},{"issue":"1","key":"10.1016\/j.bbih.2023.100622_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-23832-3","article-title":"Decreased PPARgamma in the trigeminal spinal subnucleus caudalis due to neonatal injury contributes to incision-induced mechanical allodynia in female rats","volume":"12","author":"Otsuji","year":"2022","journal-title":"Sci. Rep."},{"issue":"4","key":"10.1016\/j.bbih.2023.100622_bib39","doi-asserted-by":"crossref","first-page":"1938","DOI":"10.1152\/jn.00575.2001","article-title":"Inhibition of glutamatergic synaptic input to spinal lamina II(o) neurons by presynaptic alpha(2)-adrenergic receptors","volume":"87","author":"Pan","year":"2002","journal-title":"J. Neurophysiol."},{"issue":"6048","key":"10.1016\/j.bbih.2023.100622_bib40","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science"},{"issue":"7806","key":"10.1016\/j.bbih.2023.100622_bib41","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1038\/s41586-020-2200-5","article-title":"Injured adult neurons regress to an embryonic transcriptional growth state","volume":"581","author":"Poplawski","year":"2020","journal-title":"Nature"},{"issue":"4","key":"10.1016\/j.bbih.2023.100622_bib42","doi-asserted-by":"crossref","DOI":"10.3390\/cells10040874","article-title":"Chemogenetic activation of CX3CR1-expressing spinal microglia using Gq-DREADD elicits mechanical allodynia in male mice","volume":"10","author":"Saika","year":"2021","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.bbih.2023.100622_bib43","doi-asserted-by":"crossref","first-page":"691","DOI":"10.1016\/j.neuron.2012.03.026","article-title":"Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner","volume":"74","author":"Schafer","year":"2012","journal-title":"Neuron"},{"issue":"1","key":"10.1016\/j.bbih.2023.100622_bib44","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1111\/head.12272","article-title":"Orofacial pain: a guide for the headache physician","volume":"54","author":"Shephard","year":"2014","journal-title":"Headache"},{"issue":"4","key":"10.1016\/j.bbih.2023.100622_bib45","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.stem.2010.08.014","article-title":"Microglia shape adult hippocampal neurogenesis through apoptosis-coupled phagocytosis","volume":"7","author":"Sierra","year":"2010","journal-title":"Cell Stem Cell"},{"issue":"8","key":"10.1016\/j.bbih.2023.100622_bib46","doi-asserted-by":"crossref","first-page":"1081","DOI":"10.1038\/nn.4053","article-title":"Different immune cells mediate mechanical pain hypersensitivity in male and female mice","volume":"18","author":"Sorge","year":"2015","journal-title":"Nat. Neurosci."},{"issue":"6","key":"10.1016\/j.bbih.2023.100622_bib47","doi-asserted-by":"crossref","first-page":"1164","DOI":"10.1016\/j.cell.2007.10.036","article-title":"The classical complement cascade mediates CNS synapse elimination","volume":"131","author":"Stevens","year":"2007","journal-title":"Cell"},{"issue":"2","key":"10.1016\/j.bbih.2023.100622_bib48","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41380-019-0609-8","article-title":"Microglial regional heterogeneity and its role in the brain","volume":"25","author":"Tan","year":"2020","journal-title":"Mol. Psychiatr."},{"issue":"6601","key":"10.1016\/j.bbih.2023.100622_bib49","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.abl6773","article-title":"Microglia-mediated degradation of perineuronal nets promotes pain","volume":"377","author":"Tansley","year":"2022","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bbih.2023.100622_bib50","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2021220118","article-title":"A subset of spinal dorsal horn interneurons crucial for gating touch-evoked pain-like behavior","volume":"118","author":"Tashima","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"key":"10.1016\/j.bbih.2023.100622_bib51","doi-asserted-by":"crossref","DOI":"10.1038\/srep23701","article-title":"Bone marrow-derived cells in the population of spinal microglia after peripheral nerve injury","author":"Tashima","year":"2016","journal-title":"Sci. Rep."},{"issue":"8","key":"10.1016\/j.bbih.2023.100622_bib52","doi-asserted-by":"crossref","first-page":"2580","DOI":"10.1523\/JNEUROSCI.21-08-02580.2001","article-title":"Minocycline, a tetracycline derivative, is neuroprotective against excitotoxicity by inhibiting activation and proliferation of microglia","volume":"21","author":"Tikka","year":"2001","journal-title":"J. Neurosci."},{"issue":"19","key":"10.1016\/j.bbih.2023.100622_bib53","doi-asserted-by":"crossref","first-page":"8032","DOI":"10.1073\/pnas.0810420106","article-title":"IFN-gamma receptor signaling mediates spinal microglia activation driving neuropathic pain","volume":"106","author":"Tsuda","year":"2009","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"6950","key":"10.1016\/j.bbih.2023.100622_bib54","doi-asserted-by":"crossref","first-page":"778","DOI":"10.1038\/nature01786","article-title":"P2X4 receptors induced in spinal microglia gate tactile allodynia after nerve injury","volume":"424","author":"Tsuda","year":"2003","journal-title":"Nature"},{"issue":"9","key":"10.1016\/j.bbih.2023.100622_bib55","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1007\/s11916-019-0803-z","article-title":"Off-label antidepressant use for treatment and management of chronic pain: evolving understanding and comprehensive review","volume":"23","author":"Urits","year":"2019","journal-title":"Curr. Pain Headache Rep."},{"issue":"1","key":"10.1016\/j.bbih.2023.100622_bib56","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s12874-018-0594-7","article-title":"Characterising and justifying sample size sufficiency in interview-based studies: systematic analysis of qualitative health research over a 15-year period","volume":"18","author":"Vasileiou","year":"2018","journal-title":"BMC Med. Res. Methodol."},{"issue":"4","key":"10.1016\/j.bbih.2023.100622_bib57","doi-asserted-by":"crossref","first-page":"1785","DOI":"10.1016\/j.neuroscience.2007.03.016","article-title":"Influence of peripheral nerve injury on response properties of locus coeruleus neurons and coeruleospinal antinociception in the rat","volume":"146","author":"Viisanen","year":"2007","journal-title":"Neuroscience"},{"issue":"13","key":"10.1016\/j.bbih.2023.100622_bib58","doi-asserted-by":"crossref","first-page":"3974","DOI":"10.1523\/JNEUROSCI.4363-08.2009","article-title":"Resting microglia directly monitor the functional state of synapses in vivo and determine the fate of ischemic terminals","volume":"29","author":"Wake","year":"2009","journal-title":"J. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2023.100622_bib59","doi-asserted-by":"crossref","first-page":"1228","DOI":"10.1038\/s41467-018-03566-5","article-title":"Microglia remodel synapses by presynaptic trogocytosis and spine head filopodia induction","volume":"9","author":"Weinhard","year":"2018","journal-title":"Nat. Commun."},{"issue":"3","key":"10.1016\/j.bbih.2023.100622_bib60","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/0165-0173(80)90009-0","article-title":"Descending projections of the locus coeruleus and subcoeruleus\/medial parabrachial nuclei in monkey: axonal transport studies and dopamine-beta-hydroxylase immunocytochemistry","volume":"2","author":"Westlund","year":"1980","journal-title":"Brain Res."},{"issue":"639","key":"10.1016\/j.bbih.2023.100622_bib61","doi-asserted-by":"crossref","first-page":"eabh2557","DOI":"10.1126\/scitranslmed.abh2557","article-title":"GPR177 in A-fiber sensory neurons drives diabetic neuropathic pain via WNT-mediated TRPV1 activation","volume":"14","author":"Xie","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"11","key":"10.1016\/j.bbih.2023.100622_bib62","doi-asserted-by":"crossref","first-page":"1326","DOI":"10.1038\/nm.3978","article-title":"Inhibition of mechanical allodynia in neuropathic pain by TLR5-mediated A-fiber blockade","volume":"21","author":"Xu","year":"2015","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbih.2023.100622_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2019.00504","article-title":"Differences of microglia in the brain and the spinal cord","author":"Xuan","year":"2019","journal-title":"Front. Cell. Neurosci."},{"issue":"26","key":"10.1016\/j.bbih.2023.100622_bib64","doi-asserted-by":"crossref","first-page":"15769","DOI":"10.1073\/pnas.95.26.15769","article-title":"Tetracyclines inhibit microglial activation and are neuroprotective in global brain ischemia","volume":"95","author":"Yrjanheikki","year":"1998","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"2","key":"10.1016\/j.bbih.2023.100622_bib65","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1016\/0304-3959(83)90201-4","article-title":"Ethical guidelines for investigations of experimental pain in conscious animals","volume":"16","author":"Zimmermann","year":"1983","journal-title":"Pain"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354623000364?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354623000364?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:31:14Z","timestamp":1762986674000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354623000364"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,7]]},"references-count":65,"alternative-id":["S2666354623000364"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2023.100622","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2023,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Microglia cause structural remodeling of noradrenergic axon in the trigeminal spinal subnucleus caudalis after infraorbital nerve injury in rats","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2023.100622","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100622"}}