{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T00:53:08Z","timestamp":1785459188558,"version":"3.56.0"},"reference-count":119,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2023,11,1]],"date-time":"2023-11-01T00:00:00Z","timestamp":1698796800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2023,9,16]],"date-time":"2023-09-16T00:00:00Z","timestamp":1694822400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000065","name":"National Institute of Neurological Disorders and Stroke","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000065","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2023,11]]},"DOI":"10.1016\/j.bbih.2023.100688","type":"journal-article","created":{"date-parts":[[2023,9,17]],"date-time":"2023-09-17T11:37:53Z","timestamp":1694950673000},"page":"100688","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":13,"special_numbering":"C","title":["A potential therapeutic target: The role of neutrophils in the central nervous system"],"prefix":"10.1016","volume":"33","author":[{"given":"Isabel","family":"Salken","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Javier","family":"Provencio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9184-895X","authenticated-orcid":false,"given":"Aminata P.","family":"Coulibaly","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1464","key":"10.1016\/j.bbih.2023.100688_bib1","doi-asserted-by":"crossref","first-page":"2309","DOI":"10.1098\/rstb.2005.1766","article-title":"The role of an astrocytic NADPH oxidase in the neurotoxicity of amyloid beta peptides","volume":"360","author":"Abramov","year":"2005","journal-title":"Philos Trans R Soc B Biol Sci"},{"issue":"5","key":"10.1016\/j.bbih.2023.100688_bib2","doi-asserted-by":"crossref","first-page":"334","DOI":"10.1016\/j.it.2016.03.005","article-title":"Aging: a temporal dimension for neutrophils","volume":"37","author":"Adrover","year":"2016","journal-title":"Trends Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1038\/s41467-020-20599-x","article-title":"Intratumoral IL-12 delivery empowers CAR-T cell immunotherapy in a pre-clinical model of glioblastoma","volume":"12","author":"Agliardi","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2023.100688_bib4","volume":"vol. 361","author":"Albrengues","year":"2019"},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib5","doi-asserted-by":"crossref","first-page":"381","DOI":"10.4049\/jimmunol.1200409","article-title":"Neutrophil cerebrovascular transmigration triggers rapid neurotoxicity through release of proteases associated with decondensed DNA","volume":"189","author":"Allen","year":"2012","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbih.2023.100688_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2022.949451","article-title":"Extracellular vesicles from A23187-treated neutrophils cause cGAS-STING-dependent IL-6 production by macrophages","volume":"13","author":"Allen","year":"2022","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2023.100688_bib7","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1146\/annurev-immunol-020711-074942","article-title":"Neutrophil function: from mechanisms to disease","volume":"30","author":"Amulic","year":"2012","journal-title":"Annu. Rev. Immunol."},{"issue":"8","key":"10.1016\/j.bbih.2023.100688_bib8","doi-asserted-by":"crossref","first-page":"1982","DOI":"10.1002\/ijc.29945","article-title":"Type i IFNs induce anti-tumor polarization of tumor associated neutrophils in mice and human","volume":"138","author":"Andzinski","year":"2016","journal-title":"Int. J. Cancer"},{"issue":"March","key":"10.1016\/j.bbih.2023.100688_bib9","first-page":"1","article-title":"Neutrophils as a potential therapeutic target in Alzheimer's disease","volume":"14","author":"Aries","year":"2023","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbih.2023.100688_bib10","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1084\/jem.20200652","article-title":"Targeting potential drivers of COVID-19: neutrophil extracellular traps","volume":"217","author":"Barnes","year":"2020","journal-title":"J. Exp. Med."},{"issue":"14","key":"10.1016\/j.bbih.2023.100688_bib11","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1200\/JCO.2004.12.149","article-title":"Incidence proportions of brain metastases in patients diagnosed (1973 to 2001) in the Metropolitan Detroit Cancer Surveillance System","volume":"22","author":"Barnholtz-Sloan","year":"2004","journal-title":"J. Clin. Oncol."},{"issue":"6","key":"10.1016\/j.bbih.2023.100688_bib12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1007\/s10787-017-0367-7","article-title":"Oleuropein and hydroxytyrosol inhibit the N-formyl-methionyl-leucyl-phenylalanine-induced neutrophil degranulation and chemotaxis via AKT, p38, and ERK1\/2 MAP-Kinase inhibition","volume":"25","author":"Bedouhene","year":"2017","journal-title":"Inflammopharmacology"},{"issue":"December","key":"10.1016\/j.bbih.2023.100688_bib13","article-title":"Neutrophil metabolism in the cancer context","volume":"57","author":"Bodac","year":"2021","journal-title":"Semin. Immunol."},{"issue":"5","key":"10.1016\/j.bbih.2023.100688_bib14","doi-asserted-by":"crossref","first-page":"657","DOI":"10.1016\/j.immuni.2010.11.011","article-title":"Neutrophils, from marrow to microbes","volume":"33","author":"Borregaard","year":"2010","journal-title":"Immunity"},{"issue":"5663","key":"10.1016\/j.bbih.2023.100688_bib15","doi-asserted-by":"crossref","first-page":"1532","DOI":"10.1126\/science.1092385","article-title":"Neutrophil extracellular traps kill bacteria","volume":"303","author":"Brinkmann","year":"2004","journal-title":"Science"},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib16","doi-asserted-by":"crossref","first-page":"389","DOI":"10.1038\/s42255-022-00550-8","article-title":"Switching to the cyclic pentose phosphate pathway powers the oxidative burst in activated neutrophils","volume":"4","author":"Britt","year":"2022","journal-title":"Nat. Metab."},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib17","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111128","article-title":"Engineering chimeric antigen receptor neutrophils from human pluripotent stem cells for targeted cancer immunotherapy","volume":"40","author":"Chang","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbih.2023.100688_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.redox.2022.102532","article-title":"Therapeutic inhibition of MPO stabilizes pre-existing high risk atherosclerotic plaque","volume":"58","author":"Chen","year":"2022","journal-title":"Redox Biol."},{"key":"10.1016\/j.bbih.2023.100688_bib19","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.neuropharm.2012.06.051","article-title":"The NMDA receptor as a target for cognitive enhancement","volume":"64","author":"Collingridge","year":"2013","journal-title":"Neuropharmacology"},{"issue":"4","key":"10.1016\/j.bbih.2023.100688_bib20","first-page":"1859","article-title":"Molecular sequence of events and signaling pathways in cerebral metastases","volume":"38","author":"Cooper","year":"2018","journal-title":"Anticancer Res."},{"key":"10.1016\/j.bbih.2023.100688_bib21","volume":"vol. 64","author":"Cosentino","year":"1999"},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib22","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1111\/imr.13123","article-title":"Neutrophil modulation of behavior and cognition in health and disease: the unexplored role of an innate immune cell","volume":"311","author":"Coulibaly","year":"2022","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib23","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1007\/s12028-019-00871-9","article-title":"RAR-related orphan receptor gamma T (RoR\u03b3t)-Related cytokines play a role in neutrophil infiltration of the central nervous system after subarachnoid hemorrhage","volume":"33","author":"Coulibaly","year":"2020","journal-title":"Neurocritical Care"},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib24","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1038\/s41593-018-0329-4","article-title":"Neutrophil adhesion in brain capillaries reduces cortical blood flow and impairs memory function in Alzheimer's disease mouse models","volume":"22","author":"Cruz Hern\u00e1ndez","year":"2019","journal-title":"Nat. Neurosci."},{"issue":"Suppl. 2","key":"10.1016\/j.bbih.2023.100688_bib25","article-title":"CXCR4, the master regulator of neutrophil trafficking in homeostasis and disease","volume":"48","author":"De Filippo","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"issue":"2","key":"10.1016\/j.bbih.2023.100688_bib26","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1152\/physrev.00023.2009","article-title":"Proteases and proteolysis in Alzheimer disease: a multifactorial view on the disease process","volume":"90","author":"De Strooper","year":"2010","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbih.2023.100688_bib27","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1016\/j.ebiom.2019.08.004","article-title":"NMDA receptor modulation of glutamate release in activated neutrophils","volume":"47","author":"del Arroyo","year":"2019","journal-title":"EBioMedicine"},{"key":"10.1016\/j.bbih.2023.100688_bib28","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1111\/imr.12499","article-title":"The immune system's role in sepsis progression, resolution, and long-term outcome","volume":"274","author":"Delano","year":"2016","journal-title":"Immunol. Rev."},{"issue":"5","key":"10.1016\/j.bbih.2023.100688_bib29","doi-asserted-by":"crossref","first-page":"1333","DOI":"10.1084\/jem.20161621","article-title":"Splenic Ly6Ghigh mature and Ly6Gint immature neutrophils contribute to eradication of S. pneumoniae","volume":"214","author":"Deniset","year":"2017","journal-title":"J. Exp. Med."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib30","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1073\/pnas.0303510101","article-title":"Neurotoxic effects of polymorphonuclear granulocytes on hippocampal primary cultures","volume":"101","author":"Dinkel","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"2","key":"10.1016\/j.bbih.2023.100688_bib31","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1002\/ana.25159","article-title":"Neutrophil hyperactivation correlates with Alzheimer's disease progression","volume":"83","author":"Dong","year":"2018","journal-title":"Ann. Neurol."},{"issue":"19","key":"10.1016\/j.bbih.2023.100688_bib32","doi-asserted-by":"crossref","first-page":"4711","DOI":"10.1182\/blood-2008-09-177287","article-title":"CXCR4 is a key regulator of neutrophil release from the bone marrow under basal and stress granulopoiesis conditions","volume":"113","author":"Eash","year":"2009","journal-title":"Blood"},{"issue":"9","key":"10.1016\/j.bbih.2023.100688_bib33","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.7150\/ijbs.4679","article-title":"Interleukin-6, a major cytokine in the central nervous system","volume":"8","author":"Erta","year":"2012","journal-title":"Int. J. Biol. Sci."},{"issue":"S1","key":"10.1016\/j.bbih.2023.100688_bib34","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1002\/ajh.25418","article-title":"An introduction to chimeric antigen receptor (CAR) T-cell immunotherapy for human cancer","volume":"94","author":"Feins","year":"2019","journal-title":"Am. J. Hematol."},{"issue":"7163","key":"10.1016\/j.bbih.2023.100688_bib35","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1038\/nature06185","article-title":"Phagocyte-derived catecholamines enhance acute inflammatory injury","volume":"449","author":"Flierl","year":"2007","journal-title":"Nature"},{"issue":"47","key":"10.1016\/j.bbih.2023.100688_bib36","doi-asserted-by":"crossref","first-page":"6816","DOI":"10.1038\/sj.onc.1210764","article-title":"Transcriptional control of granulocyte and monocyte development","volume":"26","author":"Friedman","year":"2007","journal-title":"Oncogene"},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib37","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1016\/j.intimp.2013.06.034","article-title":"Neutrophil cell surface receptors and their intracellular signal transduction pathways","volume":"17","author":"Futosi","year":"2013","journal-title":"Int. Immunopharm."},{"issue":"2","key":"10.1016\/j.bbih.2023.100688_bib38","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.85841","article-title":"Glioblastoma-infiltrated innate immune cells resemble M0 macrophage phenotype","volume":"1","author":"Gabrusiewicz","year":"2016","journal-title":"JCI Insight"},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib39","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s00441-017-2626-8","article-title":"Myeloperoxidase-immunoreactive cells are significantly increased in brain areas affected by neurodegeneration in Parkinson's and Alzheimer's disease","volume":"369","author":"Gellhaar","year":"2017","journal-title":"Cell Tissue Res."},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib40","doi-asserted-by":"crossref","first-page":"912","DOI":"10.1016\/j.ygyno.2006.05.043","article-title":"Lactate dehydrogenase 5 (LDH-5) expression in endometrial cancer relates to the activated VEGF\/VEGFR2(KDR) pathway and prognosis","volume":"103","author":"Giatromanolaki","year":"2006","journal-title":"Gynecol. Oncol."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib41","doi-asserted-by":"crossref","first-page":"324","DOI":"10.4049\/jimmunol.1300858","article-title":"\u03b22 integrin\u2013mediated crawling on endothelial ICAM-1 and ICAM-2 is a prerequisite for transcellular neutrophil diapedesis across the inflamed blood\u2013brain barrier","volume":"192","author":"Gorina","year":"2014","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib42","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.ccr.2011.08.012","article-title":"Tumor entrained neutrophils inhibit seeding in the premetastatic lung","volume":"20","author":"Granot","year":"2011","journal-title":"Cancer Cell"},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib43","doi-asserted-by":"crossref","first-page":"724","DOI":"10.1111\/j.1471-4159.2004.02527.x","article-title":"Neuronal expression of myeloperoxidase is increased in Alzheimer's disease","volume":"90","author":"Green","year":"2004","journal-title":"J. Neurochem."},{"issue":"6","key":"10.1016\/j.bbih.2023.100688_bib44","doi-asserted-by":"crossref","first-page":"1915","DOI":"10.3892\/ijmm.2016.2769","article-title":"CNTF protects neurons from hypoxic injury through the activation of STAT3pTyr705","volume":"38","author":"Gu","year":"2016","journal-title":"Int. J. Mol. Med."},{"key":"10.1016\/j.bbih.2023.100688_bib45","doi-asserted-by":"crossref","first-page":"925","DOI":"10.1038\/s41590-023-01505-1","article-title":"Age-induced alterations of granulopoiesis generate atypical neutrophils that aggravate stroke pathology","volume":"24","author":"Gullotta","year":"2023","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.bbih.2023.100688_bib46","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1010700","article-title":"Mitochondrial ROS production by neutrophils is required for host antimicrobial function against Streptococcus pneumoniae and is controlled by A2B adenosine receptor signaling","volume":"18","author":"Herring","year":"2022","journal-title":"PLoS Pathog."},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib47","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1189\/jlb.0702375","article-title":"Cross-talk between tumor cells and neutrophils through the Fas (APO-1, CD95)\/FasL system: human glioma cells enhance cell viability and stimulate cytokine production in neutrophils","volume":"73","author":"Hor","year":"2003","journal-title":"J. Leukoc. Biol."},{"issue":"16","key":"10.1016\/j.bbih.2023.100688_bib48","doi-asserted-by":"crossref","first-page":"2944","DOI":"10.1111\/febs.14466","article-title":"A guide to chemokines and their receptors","volume":"285","author":"Hughes","year":"2018","journal-title":"FEBS J."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib49","first-page":"1","article-title":"Neutrophil metabolic shift during their lifecycle: impact on their survival and activation","volume":"21","author":"Injarabian","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"9","key":"10.1016\/j.bbih.2023.100688_bib50","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1038\/s41568-020-0281-y","article-title":"Neutrophil diversity and plasticity in tumour progression and therapy","volume":"20","author":"Jaillon","year":"2020","journal-title":"Nat. Rev. Cancer"},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib51","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1016\/j.gendis.2017.02.003","article-title":"Aerobic glycolysis and high level of lactate in cancer metabolism and microenvironment","volume":"4","author":"Jiang","year":"2017","journal-title":"Genes Dis"},{"issue":"15","key":"10.1016\/j.bbih.2023.100688_bib52","doi-asserted-by":"crossref","first-page":"2783","DOI":"10.1182\/blood-2009-12-258491","article-title":"Lack of glucose recycling between endoplasmic reticulum and cytoplasm underlies cellular dysfunction in glucose-6-phosphatase-\u03b2-deficient neutrophils in a congenital neutropenia syndrome","volume":"116","author":"Jun","year":"2010","journal-title":"Blood"},{"key":"10.1016\/j.bbih.2023.100688_bib53","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2020.581457","article-title":"Neutrophils as orchestrators in tumor development and metastasis formation","volume":"10","author":"Kalafati","year":"2020","journal-title":"Front. Oncol."},{"issue":"September 2019","key":"10.1016\/j.bbih.2023.100688_bib54","article-title":"The role of neutrophils in neuro-immune modulation","volume":"151","author":"Kanashiro","year":"2020","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbih.2023.100688_bib55","first-page":"2689","volume":"vol. 189","author":"Kaplan","year":"2013"},{"issue":"6","key":"10.1016\/j.bbih.2023.100688_bib56","doi-asserted-by":"crossref","first-page":"6","DOI":"10.3390\/ijms21061954","article-title":"Role of neutrophils and myeloid-derived suppressor cells in glioma progression and treatment resistance","volume":"21","author":"Khan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"4","key":"10.1016\/j.bbih.2023.100688_bib57","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1002\/JLB.3A0320-210R","article-title":"Neutrophils produce proinflammatory or anti-inflammatory extracellular vesicles depending on the environmental conditions","volume":"109","author":"Kolonics","year":"2021","journal-title":"J. Leukoc. Biol."},{"issue":"13","key":"10.1016\/j.bbih.2023.100688_bib58","doi-asserted-by":"crossref","first-page":"6454","DOI":"10.1073\/pnas.93.13.6454","article-title":"Targeting of proteins to granule subsets is determined by timing and not by sorting: the specific granule protein NGAL is localized to azurophil granules when expressed in HL-60 cells","volume":"93","author":"Le Cabec","year":"1996","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"14","key":"10.1016\/j.bbih.2023.100688_bib59","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1016\/j.micinf.2003.09.014","article-title":"Phagocytosis by neutrophils","volume":"5","author":"Lee","year":"2003","journal-title":"Microb. Infect."},{"issue":"4","key":"10.1016\/j.bbih.2023.100688_bib60","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1016\/S0021-9258(18)88742-7","article-title":"The action of leucocytes on glucose","volume":"11","author":"Levene","year":"1912","journal-title":"J. Biol. Chem."},{"issue":"9","key":"10.1016\/j.bbih.2023.100688_bib61","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1038\/nri2156","article-title":"Getting to the site of inflammation: the leukocyte adhesion cascade updated","volume":"7","author":"Ley","year":"2007","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib62","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s12964-019-0471-y","article-title":"The regulatory roles of neutrophils in adaptive immunity","volume":"17","author":"Li","year":"2019","journal-title":"Cell Commun. Signal."},{"issue":"August","key":"10.1016\/j.bbih.2023.100688_bib63","first-page":"1","article-title":"Roles of neutrophils in glioma and brain metastases","volume":"12","author":"Lin","year":"2021","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib64","doi-asserted-by":"crossref","first-page":"610","DOI":"10.1038\/ki.1992.325","article-title":"Mild renal ischemia activates primed neutrophils to cause acute renal failure","volume":"42","author":"Linas","year":"1992","journal-title":"Kidney Int."},{"issue":"5","key":"10.1016\/j.bbih.2023.100688_bib65","doi-asserted-by":"crossref","DOI":"10.1002\/jev2.12223","article-title":"Extracellular vesicles from lung tissue drive bone marrow neutrophil recruitment in inflammation","volume":"11","author":"Liu","year":"2022","journal-title":"J. Extracell. Vesicles"},{"issue":"2","key":"10.1016\/j.bbih.2023.100688_bib66","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1002\/JLB.4MR0820-011R","article-title":"Brief review on the roles of neutrophils in cancer development","volume":"109","author":"Long","year":"2021","journal-title":"J. Leukoc. Biol."},{"issue":"14","key":"10.1016\/j.bbih.2023.100688_bib67","doi-asserted-by":"crossref","first-page":"1752","DOI":"10.1038\/onc.2012.201","article-title":"Neutrophil chemokines secreted by tumor cells mount a lung antimetastatic response during renal cell carcinoma progression","volume":"32","author":"L\u00f3pez-Lago","year":"2013","journal-title":"Oncogene"},{"issue":"2","key":"10.1016\/j.bbih.2023.100688_bib68","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1038\/sj.cdd.4401320","article-title":"Functional characterization of mitochondria in neutrophils: a role restricted to apoptosis","volume":"11","author":"Maianski","year":"2004","journal-title":"Cell Death Differ."},{"issue":"8","key":"10.1016\/j.bbih.2023.100688_bib69","doi-asserted-by":"crossref","first-page":"889","DOI":"10.1002\/glia.20973","article-title":"The role and therapeutic potential of monocytic cells in Alzheimer's disease","volume":"58","author":"Malm","year":"2010","journal-title":"Glia"},{"issue":"12","key":"10.1016\/j.bbih.2023.100688_bib70","doi-asserted-by":"crossref","DOI":"10.3390\/cells8121477","article-title":"The brain entangled: the contribution of neutrophil extracellular traps to the diseases of the central nervous system","volume":"8","author":"Manda-Handzlik","year":"2019","journal-title":"Cells"},{"issue":"November","key":"10.1016\/j.bbih.2023.100688_bib71","first-page":"1","article-title":"Tumor associated neutrophils. Their role in tumorigenesis, metastasis, prognosis and therapy","volume":"9","author":"Masucci","year":"2019","journal-title":"Front. Oncol."},{"issue":"6","key":"10.1016\/j.bbih.2023.100688_bib72","doi-asserted-by":"crossref","DOI":"10.1172\/JCI143759","article-title":"Neutrophil dynamics in the tumor microenvironment","volume":"131","author":"McFarlane","year":"2021","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbih.2023.100688_bib73","first-page":"16","volume":"vol. 5","author":"McKenzie","year":"1998"},{"issue":"10","key":"10.1016\/j.bbih.2023.100688_bib74","doi-asserted-by":"crossref","first-page":"1169","DOI":"10.1182\/blood.2020007008","article-title":"Neutrophil extracellular traps contribute to immunothrombosis in COVID-19 acute respiratory distress syndrome","volume":"136","author":"Middleton","year":"2020","journal-title":"Blood"},{"issue":"6","key":"10.1016\/j.bbih.2023.100688_bib75","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1002\/jlb.65.6.875","article-title":"Regulation of neutrophil Fc\u03b3RIIIb (CD16) surface expression following delayed apoptosis in response to GM-CSF and sodium butyrate","volume":"65","author":"Moulding","year":"1999","journal-title":"J. Leukoc. Biol."},{"issue":"JULY","key":"10.1016\/j.bbih.2023.100688_bib76","article-title":"Regulatory interactions between neutrophils, tumor cells and T Cells","volume":"10","author":"Oberg","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.bbih.2023.100688_bib77","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1038\/nri.2017.105","article-title":"Neutrophil extracellular traps in immunity and disease","volume":"18","author":"Papayannopoulos","year":"2018","journal-title":"Nat. Rev. Immunol."},{"issue":"MAR","key":"10.1016\/j.bbih.2023.100688_bib78","first-page":"1","article-title":"NETosis in Alzheimer's disease","volume":"8","author":"Pietronigro","year":"2017","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib79","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1016\/j.ccell.2017.02.009","article-title":"The microenvironmental landscape of brain tumors","volume":"31","author":"Quail","year":"2017","journal-title":"Cancer Cell"},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib80","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1111\/imr.12452","article-title":"Molecular mechanisms regulating secretory organelles and endosomes in neutrophils and their implications for inflammation","volume":"273","author":"Ramadass","year":"2016","journal-title":"Immunol. Rev."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib81","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1007\/s10555-020-09951-1","article-title":"Neutrophil-derived granule cargoes: paving the way for tumor growth and progression","volume":"40","author":"Rawat","year":"2021","journal-title":"Cancer Metastasis Rev."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib82","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-07505-2","article-title":"Tumour-elicited neutrophils engage mitochondrial metabolism to circumvent nutrient limitations and maintain immune suppression","volume":"9","author":"Rice","year":"2018","journal-title":"Nat. Commun."},{"issue":"7","key":"10.1016\/j.bbih.2023.100688_bib83","doi-asserted-by":"crossref","first-page":"1542","DOI":"10.1016\/j.bpj.2014.07.070","article-title":"The mechanism of phagocytosis: two stages of engulfment","volume":"107","author":"Richards","year":"2014","journal-title":"Biophys. J."},{"issue":"8","key":"10.1016\/j.bbih.2023.100688_bib84","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.ppat.1008230","article-title":"CXCR4 and MIF are required for neutrophil extracellular trap release triggered by Plasmodium-infected erythrocytes","volume":"16","author":"Rodrigues","year":"2020","journal-title":"PLoS Pathog."},{"issue":"6","key":"10.1016\/j.bbih.2023.100688_bib85","doi-asserted-by":"crossref","first-page":"1439","DOI":"10.1189\/jlb.1008606","article-title":"Ficolin-1 is present in a highly mobilizable subset of human neutrophil granules and associates with the cell surface after stimulation with fMLP","volume":"86","author":"R\u00f8rvig","year":"2009","journal-title":"J. Leukoc. Biol."},{"key":"10.1016\/j.bbih.2023.100688_bib86","doi-asserted-by":"crossref","first-page":"113","DOI":"10.3389\/fphys.2018.00113","article-title":"Neutrophil: a cell with many roles in inflammation or several cell types?","volume":"9","author":"Rosales","year":"2018","journal-title":"Front. Physiol."},{"issue":"3","key":"10.1016\/j.bbih.2023.100688_bib87","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0214150","article-title":"Myeloperoxidase inhibition in mice alters atherosclerotic lesion composition","volume":"14","author":"Roth Flach","year":"2019","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbih.2023.100688_bib88","doi-asserted-by":"crossref","first-page":"411","DOI":"10.1016\/j.cmet.2020.11.016","article-title":"Neutrophils fuel effective immune responses through gluconeogenesis and glycogenesis","volume":"33","author":"Sadiku","year":"2021","journal-title":"Cell Metabol."},{"issue":"2","key":"10.1016\/j.bbih.2023.100688_bib89","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0032366","article-title":"Neutrophil extracellular traps directly induce epithelial and endothelial cell death: a predominant role of histones","volume":"7","author":"Saffarzadeh","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib90","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1128\/iai.63.1.73-81.1995","article-title":"Human immunoglobulin G (IgG) Fc receptor IIA (CD32) polymorphism and IgG2- mediated bacterial phagocytosis by neutrophils","volume":"63","author":"Sanders","year":"1995","journal-title":"Infect. Immun."},{"issue":"12","key":"10.1016\/j.bbih.2023.100688_bib91","doi-asserted-by":"crossref","first-page":"1496","DOI":"10.1038\/s41590-020-00813-0","article-title":"A new neutrophil subset promotes CNS neuron survival and axon regeneration","volume":"21","author":"Sas","year":"2020","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbih.2023.100688_bib92","first-page":"47","article-title":"Neutrophilia as a biomarker for overall survival in newly diagnosed high-grade glioma patients undergoing chemoradiation","volume":"10","author":"Schernberg","year":"2018","journal-title":"Clin Transl Radiat Oncol"},{"issue":"45","key":"10.1016\/j.bbih.2023.100688_bib93","first-page":"799","article-title":"Die gliome des erwachsenen","volume":"107","author":"Schneider","year":"2010","journal-title":"Dtsch. \u00c4rztebl."},{"key":"10.1016\/j.bbih.2023.100688_bib94","doi-asserted-by":"crossref","DOI":"10.1016\/j.jbior.2020.100741","article-title":"Devilishly radical NETwork in COVID-19: oxidative stress, neutrophil extracellular traps (NETs), and T cell suppression","volume":"77","author":"Sch\u00f6nrich","year":"2020","journal-title":"Adv Biol Regul"},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib95","doi-asserted-by":"crossref","DOI":"10.1186\/s40635-017-0157-y","article-title":"Myeloperoxidase can differentiate between sepsis and non-infectious SIRS and predicts mortality in intensive care patients with SIRS","volume":"5","author":"Schrijver","year":"2017","journal-title":"Intensive Care Med Exp"},{"issue":"8","key":"10.1016\/j.bbih.2023.100688_bib96","doi-asserted-by":"crossref","first-page":"4157","DOI":"10.4049\/jimmunol.154.8.4157","article-title":"Mobilization of granules and secretory vesicles during in vivo exudation of human neutrophils","volume":"154","author":"Sengel\u00f8v","year":"1995","journal-title":"J. Immunol."},{"issue":"2","key":"10.1016\/j.bbih.2023.100688_bib97","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1016\/j.expneurol.2007.11.024","article-title":"Activated polymorphonuclear cells promote injury and excitability of dorsal root ganglia neurons","volume":"210","author":"Shaw","year":"2008","journal-title":"Exp. Neurol."},{"issue":"SEP","key":"10.1016\/j.bbih.2023.100688_bib98","first-page":"1","article-title":"Granule protein processing and regulated secretion in neutrophils","volume":"5","author":"Sheshachalam","year":"2014","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib99","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s40478-022-01347-2","article-title":"Neutrophil-vascular interactions drive myeloperoxidase accumulation in the brain in Alzheimer's disease","volume":"10","author":"Smyth","year":"2022","journal-title":"Acta Neuropathol Commun"},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib100","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s12974-018-1284-4","article-title":"The role of neutrophil granule proteins in neuroinflammation and Alzheimer's disease","volume":"15","author":"Stock","year":"2018","journal-title":"J. Neuroinflammation"},{"issue":"7745","key":"10.1016\/j.bbih.2023.100688_bib101","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/s41586-019-0915-y","article-title":"Neutrophils escort circulating tumour cells to enable cell cycle progression","volume":"566","author":"Szczerba","year":"2019","journal-title":"Nature"},{"issue":"10","key":"10.1016\/j.bbih.2023.100688_bib102","doi-asserted-by":"crossref","first-page":"5287","DOI":"10.4049\/jimmunol.168.10.5287","article-title":"Localized exocytosis of primary (lysosomal) granules during phagocytosis: role of Ca 2+ -dependent tyrosine phosphorylation and microtubules","volume":"168","author":"Tapper","year":"2002","journal-title":"J. Immunol."},{"issue":"OCT","key":"10.1016\/j.bbih.2023.100688_bib103","first-page":"1","article-title":"Neutrophil-derived cytokines: facts beyond expression","volume":"5","author":"Tecchio","year":"2014","journal-title":"Front. Immunol."},{"issue":"12","key":"10.1016\/j.bbih.2023.100688_bib104","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20201129","article-title":"SARS-CoV-2-triggered neutrophil extracellular traps mediate COVID-19 pathology","volume":"217","author":"Veras","year":"2020","journal-title":"J. Exp. Med."},{"issue":"9","key":"10.1016\/j.bbih.2023.100688_bib105","doi-asserted-by":"crossref","first-page":"1697","DOI":"10.1136\/ard.2009.122655","article-title":"IL-33 induces neutrophil migration in rheumatoid arthritis and is a target of anti-TNF therapy","volume":"69","author":"Verri","year":"2010","journal-title":"Ann. Rheum. Dis."},{"issue":"6","key":"10.1016\/j.bbih.2023.100688_bib106","doi-asserted-by":"crossref","first-page":"683","DOI":"10.1007\/s10875-004-6243-4","article-title":"Oxidative stress level in circulating neutrophils is linked to neurodegenerative diseases","volume":"24","author":"Vitte","year":"2004","journal-title":"J. Clin. Immunol."},{"issue":"June","key":"10.1016\/j.bbih.2023.100688_bib107","first-page":"1","article-title":"Priming and de-priming of neutrophil responses in vitro and in vivo","volume":"48","author":"Vogt","year":"2018","journal-title":"Eur. J. Clin. Invest."},{"key":"10.1016\/j.bbih.2023.100688_bib108","volume":"vol. 18","author":"Vojtechova","year":"2022"},{"issue":"September","key":"10.1016\/j.bbih.2023.100688_bib109","first-page":"1","article-title":"Myeloperoxidase deficiency inhibits cognitive decline in the 5XFAD mouse model of Alzheimer's disease","volume":"13","author":"Volkman","year":"2019","journal-title":"Front. Neurosci."},{"issue":"14","key":"10.1016\/j.bbih.2023.100688_bib110","doi-asserted-by":"crossref","first-page":"1991","DOI":"10.1182\/blood-2016-10-744441","article-title":"Neutrophils acquire the capacity for antigen presentation to memory CD4+ T cells in vitro and ex vivo","volume":"129","author":"Vono","year":"2017","journal-title":"Blood"},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib111","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1084\/jem.20040624","article-title":"Hypoxia-induced neutrophil survival is mediated by HIF-1\u03b1-dependent NF-\u03baB activity","volume":"201","author":"Walmsley","year":"2005","journal-title":"J. Exp. Med."},{"issue":"JUN","key":"10.1016\/j.bbih.2023.100688_bib112","article-title":"S100A8\/A9 in inflammation","volume":"9","author":"Wang","year":"2018","journal-title":"Front. Immunol."},{"issue":"47","key":"10.1016\/j.bbih.2023.100688_bib113","doi-asserted-by":"crossref","first-page":"36713","DOI":"10.1074\/jbc.M003017200","article-title":"Priming of the neutrophil respiratory burst involves p38 mitogen-activated protein kinase-dependent exocytosis of flavocytochrome b558-containing granules","volume":"275","author":"Ward","year":"2000","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib114","article-title":"Amyloid beta is an early responder cytokine and immunopeptide of the innate immune system","volume":"6","author":"Weaver","year":"2020","journal-title":"Alzheimer\u2019s Dement Transl Res Clin Interv"},{"issue":"1","key":"10.1016\/j.bbih.2023.100688_bib115","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1164\/ajrccm\/136.1.19","article-title":"Neutrophil-mediated pulmonary vascular injury. Synergistic effect of trace amounts of lipopolysaccharide and neutrophil stimuli on vascular permeability and neutrophil sequestration in the lung","volume":"136","author":"Worthen","year":"1987","journal-title":"Am. Rev. Respir. Dis."},{"key":"10.1016\/j.bbih.2023.100688_bib116","doi-asserted-by":"crossref","DOI":"10.1155\/2019\/8016254","article-title":"Different faces for different places: heterogeneity of neutrophil phenotype and function","volume":"2019","author":"Yang","year":"2019","journal-title":"J Immunol Res"},{"issue":"16","key":"10.1016\/j.bbih.2023.100688_bib117","doi-asserted-by":"crossref","first-page":"2784","DOI":"10.1182\/blood-2013-04-457671","article-title":"NETosis: how vital is it?","volume":"122","author":"Yipp","year":"2013","journal-title":"Blood"},{"issue":"8","key":"10.1016\/j.bbih.2023.100688_bib118","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1038\/nm.3913","article-title":"Neutrophils promote Alzheimer's disease-like pathology and cognitive decline via LFA-1 integrin","volume":"21","author":"Zenaro","year":"2015","journal-title":"Nat Med"},{"issue":"12","key":"10.1016\/j.bbih.2023.100688_bib119","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1089\/ars.2012.5019","article-title":"Hypoxia and metabolic properties of hematopoietic stem cells","volume":"20","author":"Zhang","year":"2014","journal-title":"Antioxidants Redox Signal."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354623001023?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354623001023?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,12]],"date-time":"2025-11-12T22:29:09Z","timestamp":1762986549000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354623001023"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,11]]},"references-count":119,"alternative-id":["S2666354623001023"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2023.100688","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2023,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A potential therapeutic target: The role of neutrophils in the central nervous system","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2023.100688","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2023 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100688"}}