{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:29:44Z","timestamp":1783484984908,"version":"3.55.0"},"reference-count":64,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,10,28]],"date-time":"2024-10-28T00:00:00Z","timestamp":1730073600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2024,12]]},"DOI":"10.1016\/j.bbih.2024.100899","type":"journal-article","created":{"date-parts":[[2024,11,16]],"date-time":"2024-11-16T14:40:14Z","timestamp":1731768014000},"page":"100899","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":7,"special_numbering":"C","title":["Associations of plasma SMOC1 and soluble IL6RA levels with the progression from mild cognitive impairment to dementia"],"prefix":"10.1016","volume":"42","author":[{"given":"Xavier","family":"Morat\u00f3","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raquel","family":"Puerta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Cano","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adelina","family":"Orellana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"de Rojas","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda","family":"Capdevila","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Montrreal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mait\u00e9e","family":"Rosende-Roca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo","family":"Garc\u00eda-Gonz\u00e1lez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Claudia","family":"Oliv\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Garc\u00eda-Guti\u00e9rrez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Josep","family":"Bl\u00e1zquez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea","family":"Miguel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ra\u00fal","family":"N\u00fa\u00f1ez-Llaves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vanesa","family":"Pytel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Montserrat","family":"Alegret","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Victoria","family":"Fern\u00e1ndez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marta","family":"Marqui\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergi","family":"Valero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Enrique","family":"Cavazos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Santos","family":"Ma\u00f1es","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Merc\u00e8","family":"Boada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alfredo","family":"Cabrera-Socorro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2633-2495","authenticated-orcid":false,"given":"Agust\u00edn","family":"Ruiz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2024.100899_bib1","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1016\/j.ajhg.2010.12.002","article-title":"Mutations in the SPARC-related modular calcium-binding protein 1 gene, SMOC1, cause waardenburg anophthalmia syndrome","volume":"88","author":"Abouzeid","year":"2011","journal-title":"Am. J. Hum. Genet."},{"key":"10.1016\/j.bbih.2024.100899_bib2","doi-asserted-by":"crossref","first-page":"1913","DOI":"10.1002\/alz.12841","article-title":"Plasma and CSF biomarkers in a memory clinic: head-to-head comparison of phosphorylated tau immunoassays","volume":"19","author":"Ashton","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2024.100899_bib3","doi-asserted-by":"crossref","first-page":"W147","DOI":"10.1093\/nar\/gkw419","article-title":"Heatmapper: web-enabled heat mapping for all","volume":"44","author":"Babicki","year":"2016","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbih.2024.100899_bib4","doi-asserted-by":"crossref","DOI":"10.15252\/msb.20199356","article-title":"Proteome profiling in cerebrospinal fluid reveals novel biomarkers of Alzheimer's disease","volume":"16","author":"Bader","year":"2020","journal-title":"Mol. Syst. Biol."},{"key":"10.1016\/j.bbih.2024.100899_bib5","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1007\/s00406-003-0405-x","article-title":"Polymorphisms of the gene encoding the inflammatory cytokine interleukin-6 determine the magnitude of the increase in soluble interleukin-6 receptor levels in Alzheimer's disease. Results of a pilot study","volume":"253","author":"Bagli","year":"2003","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.bbih.2024.100899_bib6","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1016\/j.neuron.2019.12.015","article-title":"Deep Multilayer brain proteomics identifies molecular networks in Alzheimer's disease progression","volume":"105","author":"Bai","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.bbih.2024.100899_bib7","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer's disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbih.2024.100899_bib8","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1038\/s41588-022-01024-z","article-title":"New insights into the genetic etiology of Alzheimer's disease and related dementias","volume":"54","author":"Bellenguez","year":"2022","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbih.2024.100899_bib9","doi-asserted-by":"crossref","first-page":"1471","DOI":"10.1001\/jamaneurol.2021.3671","article-title":"Differences between plasma and cerebrospinal fluid glial fibrillary Acidic protein levels across the Alzheimer disease continuum","volume":"78","author":"Benedet","year":"2021","journal-title":"JAMA Neurol."},{"key":"10.1016\/j.bbih.2024.100899_bib10","doi-asserted-by":"crossref","first-page":"385","DOI":"10.3233\/JAD-170602","article-title":"Cerebrospinal fluid and plasma levels of inflammation differentially relate to CNS markers of Alzheimer's disease pathology and neuronal damage","volume":"62","author":"Bettcher","year":"2018","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2024.100899_bib11","doi-asserted-by":"crossref","DOI":"10.1002\/alz.13455","article-title":"The potential clinical value of plasma biomarkers in Alzheimer's disease","volume":"19","author":"Blennow","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2024.100899_bib12","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1001\/archneur.55.10.1305","article-title":"T-lymphocyte interleukin 6 receptor binding in patients with dementia of Alzheimer type","volume":"55","author":"Bongioanni","year":"1998","journal-title":"Arch. Neurol."},{"key":"10.1016\/j.bbih.2024.100899_bib13","doi-asserted-by":"crossref","first-page":"1385","DOI":"10.3233\/JAD-221010","article-title":"Cerebrospinal fluid sTREM-2, GFAP, and \u03b2-S100 in Symptomatic Sporadic Alzheimer's disease: microglial, Astrocytic, and APOE Contributions along the Alzheimer's disease continuum","volume":"92","author":"Bonomi","year":"2023","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2024.100899_bib14","doi-asserted-by":"crossref","first-page":"629","DOI":"10.3233\/JAD-201565","article-title":"Different inflammatory signatures in Alzheimer's disease and frontotemporal dementia cerebrospinal fluid","volume":"81","author":"Bostr\u00f6m","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2024.100899_bib15","doi-asserted-by":"crossref","first-page":"2503","DOI":"10.1523\/JNEUROSCI.2830-13.2014","article-title":"Trans-signaling is a dominant mechanism for the pathogenic actions of interleukin-6 in the brain","volume":"34","author":"Campbell","year":"2014","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2024.100899_bib16","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-14755-5","article-title":"Assessment of Variability in the SOMAscan assay","volume":"7","author":"Candia","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2024.100899_bib17","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1016\/j.bbamcr.2009.12.001","article-title":"ADAM17-mediated shedding of the IL6R induces cleavage of the membrane stub by gamma-secretase","volume":"1803","author":"Chalaris","year":"2010","journal-title":"Biochim. Biophys. Acta"},{"key":"10.1016\/j.bbih.2024.100899_bib18","doi-asserted-by":"crossref","first-page":"1110","DOI":"10.1038\/s41590-023-01521-1","article-title":"Monocyte-derived IL-6 programs microglia to rebuild damaged brain vasculature","volume":"24","author":"Choi","year":"2023","journal-title":"Nat. Immunol."},{"key":"10.1016\/j.bbih.2024.100899_bib19","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1038\/s41374-022-00830-7","article-title":"High-throughput proteomics: a methodological mini-review","volume":"102","author":"Cui","year":"2022","journal-title":"Laboratory Investigation 2022"},{"key":"10.1016\/j.bbih.2024.100899_bib20","doi-asserted-by":"crossref","DOI":"10.1186\/s13195-022-01113-5","article-title":"Multi-platform proteomic analysis of Alzheimer's disease cerebrospinal fluid and plasma reveals network biomarkers associated with proteostasis and the matrisome","volume":"14","author":"Dammer","year":"2022","journal-title":"Alzheimer's Res. Ther."},{"key":"10.1016\/j.bbih.2024.100899_bib21","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.1021\/acs.jproteome.8b00809","article-title":"Proteomes of paired human cerebrospinal fluid and plasma: relation to blood-brain barrier permeability in Older adults","volume":"18","author":"Dayon","year":"2019","journal-title":"J. Proteome Res."},{"key":"10.1016\/j.bbih.2024.100899_bib22","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-021-22491-8","article-title":"Common variants in Alzheimer's disease and risk stratification by polygenic risk scores","volume":"12","author":"de Rojas","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2024.100899_bib23","doi-asserted-by":"crossref","first-page":"1963","DOI":"10.1681\/ASN.2008060653","article-title":"Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1","volume":"20","author":"Dreieicher","year":"2009","journal-title":"J. Am. Soc. Nephrol."},{"key":"10.1016\/j.bbih.2024.100899_bib24","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-022-01356-1","article-title":"The amyloid plaque proteome in early onset Alzheimer's disease and Down syndrome","volume":"10","author":"Drummond","year":"2022","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.bbih.2024.100899_bib25","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3233\/JAD-122002","article-title":"A longitudinal follow-up of 550 mild cognitive impairment patients: evidence for large conversion to dementia rates and detection of major risk factors involved","volume":"34","author":"Espinosa","year":"2013","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2024.100899_bib26","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.3233\/JAD-210254","article-title":"BIOFACE: a Prospective study of risk factors, cognition, and biomarkers in a cohort of individuals with early-onset mild cognitive impairment. Study Rationale and research protocols","volume":"83","author":"Esteban De Antonio","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2024.100899_bib27","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1038\/s41380-023-01976-6","article-title":"The association between inflammatory markers in blood and cerebrospinal fluid: a systematic review and meta-analysis","volume":"28","author":"Gigase","year":"2023","journal-title":"Molecular Psychiatry 2023"},{"key":"10.1016\/j.bbih.2024.100899_bib28","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0015004","article-title":"Aptamer-based multiplexed proteomic technology for biomarker discovery","volume":"5","author":"Gold","year":"2010","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2024.100899_bib29","doi-asserted-by":"crossref","first-page":"356","DOI":"10.1016\/S0006-8993(97)01355-3","article-title":"Decreased soluble interleukin-6 receptor in cerebrospinal fluid of patients with Alzheimer's disease","volume":"780","author":"Hampel","year":"1998","journal-title":"Brain Res."},{"key":"10.1016\/j.bbih.2024.100899_bib30","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s00406-004-0558-2","article-title":"Pattern of interleukin-6 receptor complex immunoreactivity between cortical regions of rapid autopsy normal and Alzheimer's disease brain","volume":"255","author":"Hampel","year":"2005","journal-title":"Eur Arch Psychiatry Clin Neurosci"},{"key":"10.1016\/j.bbih.2024.100899_bib31","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1002\/alz.12316","article-title":"The Alzheimer's Association international guidelines for handling of cerebrospinal fluid for routine clinical measurements of amyloid \u03b2 and tau","volume":"17","author":"Hansson","year":"2021","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2024.100899_bib32","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1152\/physrev.00011.2010","article-title":"Physiology of microglia","volume":"91","author":"Helmut","year":"2011","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbih.2024.100899_bib33","doi-asserted-by":"crossref","DOI":"10.1002\/alz.13859","article-title":"Revised criteria for diagnosis and staging of Alzheimer's disease: Alzheimer's Association Workgroup","author":"Jack","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2024.100899_bib34","doi-asserted-by":"crossref","first-page":"1979","DOI":"10.1038\/s41591-023-02476-4","article-title":"Cerebrospinal fluid proteomics define the natural history of autosomal dominant Alzheimer's disease","volume":"29","author":"Johnson","year":"2023","journal-title":"Nat Med"},{"key":"10.1016\/j.bbih.2024.100899_bib35","doi-asserted-by":"crossref","first-page":"658","DOI":"10.1016\/j.jalz.2014.05.1757","article-title":"Convergent genetic and expression data implicate immunity in Alzheimer's disease","volume":"11","author":"Jones","year":"2015","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2024.100899_bib36","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1056\/NEJMoa1211103","article-title":"Variant of TREM2 associated with the risk of Alzheimer's disease","volume":"368","author":"Jonsson","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbih.2024.100899_bib37","doi-asserted-by":"crossref","first-page":"2526","DOI":"10.1093\/eurheartj\/ehad293","article-title":"Modifiable cardiovascular risk factors and genetics for targeted prevention of dementia","volume":"44","author":"Juul Rasmussen","year":"2023","journal-title":"Eur. Heart J."},{"key":"10.1016\/j.bbih.2024.100899_bib38","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1038\/s41588-019-0358-2","article-title":"Genetic meta-analysis of diagnosed Alzheimer's disease identifies new risk loci and implicates A\u03b2, tau, immunity and lipid processing","volume":"51","author":"Kunkle","year":"2019","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbih.2024.100899_bib39","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2302720120","article-title":"Multiancestry analysis of the HLA locus in Alzheimer's and Parkinson's diseases uncovers a shared adaptive immune response mediated by HLA-DRB1\u221704 subtypes","volume":"120","author":"Le Guen","year":"2023","journal-title":"Proc Natl Acad Sci U S A"},{"key":"10.1016\/j.bbih.2024.100899_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms24021371","article-title":"The synergic effect of AT(N) profiles and Depression on the risk of conversion to dementia in patients with mild cognitive impairment","volume":"24","author":"Marqui\u00e9","year":"2023","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbih.2024.100899_bib41","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1007\/s00401-013-1177-7","article-title":"The amyloid cascade-inflammatory hypothesis of Alzheimer disease: implications for therapy","volume":"126","author":"McGeer","year":"2013","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbih.2024.100899_bib42","doi-asserted-by":"crossref","first-page":"C554","DOI":"10.1152\/ajpcell.00323.2020","article-title":"Overlapping and distinct biological effects of IL-6 classic and trans-signaling in vascular endothelial cells","volume":"320","author":"Montgomery","year":"2021","journal-title":"Am J Physiol Cell Physiol"},{"key":"10.1016\/j.bbih.2024.100899_bib43","doi-asserted-by":"crossref","DOI":"10.3390\/ijms23136891","article-title":"Establishing in-House cutoffs of CSF Alzheimer's disease biomarkers for the AT(N) stratification of the Alzheimer center Barcelona cohort","volume":"23","author":"Orellana","year":"2022","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbih.2024.100899_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2018.00245","article-title":"Blood-cerebrospinal fluid barrier Gradients in mild cognitive impairment and Alzheimer's disease: Relationship to inflammatory cytokines and chemokines","volume":"10","author":"Ott","year":"2018","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbih.2024.100899_bib45","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1002\/ana.25246","article-title":"Combined neuropathological pathways account for age-related risk of dementia","volume":"84","author":"Power","year":"2018","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbih.2024.100899_bib46","doi-asserted-by":"crossref","DOI":"10.1002\/alz.082299","article-title":"Head\u2010to\u2010head comparison of aptamer\u2010 and antibody\u2010based proteomic platforms in CSF samples of a real\u2010world large cohort of a memory clinic","volume":"19","author":"Puerta","year":"2023","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.bbih.2024.100899_bib47","article-title":"Levels of soluble interleukin 6 receptor and Asp358Ala are associated with cognitive performance and Alzheimer disease biomarkers","volume":"10","author":"Quillen","year":"2023","journal-title":"Neurology(R) neuroimmunology & neuroinflammation"},{"key":"10.1016\/j.bbih.2024.100899_bib48","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0169-328X(97)00356-2","article-title":"Enhancement of beta-amyloid precursor protein transcription and expression by the soluble interleukin-6 receptor\/interleukin-6 complex","volume":"55","author":"Ringheim","year":"1998","journal-title":"Mol. Brain Res."},{"key":"10.1016\/j.bbih.2024.100899_bib49","first-page":"100","article-title":"FACEHBI: a Prospective study of risk factors, biomarkers and cognition in a cohort of individuals with subjective cognitive decline. Study Rationale and research protocols","volume":"4","author":"Rodriguez-Gomez","year":"2017","journal-title":"J Prev Alzheimers Dis"},{"key":"10.1016\/j.bbih.2024.100899_bib50","doi-asserted-by":"crossref","first-page":"666","DOI":"10.1038\/s41577-023-00856-y","article-title":"Targeting IL-6 trans-signalling: past, present and future prospects","volume":"23","author":"Rose-John","year":"2023","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2024.100899_bib51","doi-asserted-by":"crossref","first-page":"988","DOI":"10.1111\/jnc.15116","article-title":"Quantitative proteomic analysis of the frontal cortex in Alzheimer's disease","volume":"156","author":"Sathe","year":"2021","journal-title":"J. Neurochem."},{"key":"10.1016\/j.bbih.2024.100899_bib52","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.1038\/ng.3916","article-title":"Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease","volume":"49","author":"Sims","year":"2017","journal-title":"Nat. Genet."},{"key":"10.1016\/j.bbih.2024.100899_bib53","doi-asserted-by":"crossref","first-page":"136","DOI":"10.1159\/000071001","article-title":"Inflammatory markers in matched plasma and cerebrospinal fluid from patients with Alzheimer's disease","volume":"16","author":"Sun","year":"2003","journal-title":"Dement. Geriatr. Cogn. Disord"},{"key":"10.1016\/j.bbih.2024.100899_bib54","doi-asserted-by":"crossref","first-page":"D638","DOI":"10.1093\/nar\/gkac1000","article-title":"The STRING database in 2023: protein-protein association networks and functional enrichment analyses for any sequenced genome of interest","volume":"51","author":"Szklarczyk","year":"2023","journal-title":"Nucleic Acids Res."},{"key":"10.1016\/j.bbih.2024.100899_bib55","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.661838","article-title":"Blood-brain barrier Dysfunction Amplifies the development of neuroinflammation: understanding of Cellular Events in brain Microvascular endothelial cells for prevention and Treatment of BBB Dysfunction","volume":"15","author":"Takata","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbih.2024.100899_bib56","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/j.cmet.2017.05.018","article-title":"IL-6\/Stat3-Dependent Induction of a distinct, Obesity-associated NK cell Subpopulation Deteriorates Energy and Glucose Homeostasis","volume":"26","author":"Theurich","year":"2017","journal-title":"Cell Metab"},{"key":"10.1016\/j.bbih.2024.100899_bib57","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1093\/brain\/awab027","article-title":"Co-pathologies in Alzheimer's disease: just multiple pathologies or partners in crime?","volume":"144","author":"Tom\u00e9","year":"2021","journal-title":"Brain"},{"key":"10.1016\/j.bbih.2024.100899_bib58","first-page":"47","article-title":"Review of Pharmacotherapeutic Targets in Alzheimer's disease and its Management using Traditional Medicinal Plants","volume":"14","author":"Tripathi","year":"2024","journal-title":"Degener. Neurol. Neuromuscul. Dis."},{"key":"10.1016\/j.bbih.2024.100899_bib59","first-page":"1","article-title":"The role of peripheral inflammatory insults in Alzheimer's disease: a review and research roadmap","volume":"18","author":"Walker","year":"2023","journal-title":"Molecular Neurodegeneration 2023"},{"key":"10.1016\/j.bbih.2024.100899_bib60","first-page":"1","article-title":"Quantitative mass spectrometry analysis of cerebrospinal fluid protein biomarkers in Alzheimer's disease","volume":"10","author":"Watson","year":"2023","journal-title":"Scientific Data 2023"},{"key":"10.1016\/j.bbih.2024.100899_bib61","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-019-0795-2","article-title":"Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease","volume":"7","author":"Whelan","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.bbih.2024.100899_bib62","doi-asserted-by":"crossref","DOI":"10.1186\/s40478-019-0795-2","article-title":"Multiplex proteomics identifies novel CSF and plasma biomarkers of early Alzheimer's disease","volume":"7","author":"Whelan","year":"2019","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.bbih.2024.100899_bib63","doi-asserted-by":"crossref","DOI":"10.1016\/j.mcpro.2023.100608","article-title":"Dissecting Detergent-Insoluble proteome in Alzheimer's disease by TMTc-corrected Quantitative mass spectrometry","volume":"22","author":"Zaman","year":"2023","journal-title":"Mol. Cell. Proteomics"},{"key":"10.1016\/j.bbih.2024.100899_bib64","doi-asserted-by":"crossref","DOI":"10.1186\/s12014-020-09285-8","article-title":"Targeted mass spectrometry to quantify brain-derived cerebrospinal fluid biomarkers in Alzheimer's disease","volume":"17","author":"Zhou","year":"2020","journal-title":"Clin Proteomics"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624001777?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624001777?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,21]],"date-time":"2025-01-21T02:17:27Z","timestamp":1737425847000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354624001777"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,12]]},"references-count":64,"alternative-id":["S2666354624001777"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100899","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2024,12]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Associations of plasma SMOC1 and soluble IL6RA levels with the progression from mild cognitive impairment to dementia","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100899","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100899"}}