{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T01:17:30Z","timestamp":1790817450028,"version":"4.1.0"},"reference-count":70,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,1]],"date-time":"2024-12-01T00:00:00Z","timestamp":1733011200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbih.2024.100920","type":"journal-article","created":{"date-parts":[[2024,12,5]],"date-time":"2024-12-05T22:24:55Z","timestamp":1733437495000},"page":"100920","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium"],"prefix":"10.1016","volume":"43","author":[{"given":"Paul","family":"Denver","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas","family":"Tortorelli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karen","family":"Hov","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jens Petter","family":"Berg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lasse M.","family":"Giil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arshed","family":"Nazmi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Lopez-Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daire","family":"Healy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carol","family":"Murray","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robyn","family":"Barry","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leiv Otto","family":"Watne","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1423-5209","authenticated-orcid":false,"given":"Colm","family":"Cunningham","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2024.100920_bib1","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.99364","article-title":"Targeting inflammatory monocytes in sepsis-associated encephalopathy and long-term cognitive impairment","volume":"3","author":"Andonegui","year":"2018","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbih.2024.100920_bib2","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12987-017-0063-4","article-title":"Barrier dysfunction or drainage reduction: differentiating causes of CSF protein increase","volume":"14","author":"Asgari","year":"2017","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.bbih.2024.100920_bib3","doi-asserted-by":"crossref","first-page":"1162","DOI":"10.15252\/emmm.201606271","article-title":"Identification of a novel mechanism of blood-brain communication during peripheral inflammation via choroid plexus-derived extracellular vesicles","volume":"8","author":"Balusu","year":"2016","journal-title":"EMBO Mol. Med."},{"key":"10.1016\/j.bbih.2024.100920_bib4","doi-asserted-by":"crossref","first-page":"14641","DOI":"10.1523\/JNEUROSCI.2173-12.2012","article-title":"Intracisternal interleukin-1 receptor antagonist prevents postoperative cognitive decline and neuroinflammatory response in aged rats","volume":"32","author":"Barrientos","year":"2012","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2024.100920_bib5","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4049\/jimmunol.177.5.3344","article-title":"Functional analysis of the chemokine receptor CCR3 on airway epithelial cells","volume":"177","author":"Beck","year":"2006","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbih.2024.100920_bib6","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1016\/j.immuni.2016.04.005","article-title":"Brain endothelial- and epithelial-specific interferon receptor chain 1 drives virus-induced sickness behavior and cognitive impairment","volume":"44","author":"Blank","year":"2016","journal-title":"Immunity"},{"key":"10.1016\/j.bbih.2024.100920_bib7","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1159\/000116918","article-title":"Protein analyses in cerebrospinal fluid. I. Influence of concentration gradients for proteins on cerebrospinal fluid\/serum albumin ratio","volume":"33","author":"Blennow","year":"1993","journal-title":"Eur. Neurol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100920_bib70","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1017\/S1478951517000104","article-title":"Subsyndromal delirium in the intensive care setting: Phenomenological characteristics and discrimination of subsyndromal delirium versus no and full-syndromal delirium","volume":"16","author":"Boettger","year":"2018","journal-title":"Palliat. Support Care"},{"issue":"1","key":"10.1016\/j.bbih.2024.100920_bib8","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/alz.13419","article-title":"Advancing specificity in delirium: the delirium subtyping initiative","volume":"20","author":"Bowman","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2024.100920_bib9","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1186\/1742-2094-9-242","article-title":"Changes in serum and cerebrospinal fluid cytokines in response to non-neurological surgery: an observational study","volume":"9","author":"Bromander","year":"2012","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2024.100920_bib10","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.jpsychores.2014.06.014","article-title":"Cerebrospinal fluid markers of neuroinflammation in delirium: a role for interleukin-1beta in delirium after hip fracture","volume":"77","author":"Cape","year":"2014","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.bbih.2024.100920_bib11","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1186\/s12987-020-0173-2","article-title":"Increased age and male sex are independently associated with higher frequency of blood-cerebrospinal fluid barrier dysfunction using the albumin quotient","volume":"17","author":"Castellazzi","year":"2020","journal-title":"Fluids Barriers CNS"},{"key":"10.1016\/j.bbih.2024.100920_bib12","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1002\/ana.22082","article-title":"Role of interleukin-1beta in postoperative cognitive dysfunction","volume":"68","author":"Cibelli","year":"2010","journal-title":"Ann. Neurol."},{"issue":"11","key":"10.1016\/j.bbih.2024.100920_bib13","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1016\/j.tins.2021.07.002","article-title":"Macrophages on the margin: choroid plexus immune responses","volume":"44","author":"Cui","year":"2021","journal-title":"Trends Neurosci"},{"key":"10.1016\/j.bbih.2024.100920_bib14","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2012.07.012","article-title":"At the extreme end of the psychoneuroimmunological spectrum: delirium as a maladaptive sickness behaviour response","volume":"28","author":"Cunningham","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2024.100920_bib15","doi-asserted-by":"crossref","first-page":"1847","DOI":"10.1152\/physrev.00004.2013","article-title":"Cerebrospinal fluid secretion by the choroid plexus","volume":"93","author":"Damkier","year":"2013","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbih.2024.100920_bib16","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.1016\/j.cell.2021.04.003","article-title":"A cellular and spatial map of the choroid plexus across brain ventricles and ages","volume":"184","author":"Dani","year":"2021","journal-title":"Cell"},{"key":"10.1016\/j.bbih.2024.100920_bib17","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1038\/nrn2297","article-title":"From inflammation to sickness and depression: when the immune system subjugates the brain","volume":"9","author":"Dantzer","year":"2008","journal-title":"Nat. Rev. Neurosci."},{"key":"10.1016\/j.bbih.2024.100920_bib18","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1093\/brain\/aws190","article-title":"Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study","volume":"135","author":"Davis","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.bbih.2024.100920_bib19","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.jagp.2014.08.005","article-title":"Worsening cognitive impairment and neurodegenerative pathology progressively increase risk for delirium","volume":"23","author":"Davis","year":"2015","journal-title":"Am. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.bbih.2024.100920_bib20","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1002\/ana.26771","article-title":"Role of blood-brain barrier dysfunction in delirium following non-cardiac surgery in older adults","volume":"94","author":"Devinney","year":"2023","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbih.2024.100920_bib21","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1124\/pr.117.014647","article-title":"Neuroimmune axes of the blood-brain barriers and blood-brain interfaces: bases for physiological regulation, disease states, and pharmacological interventions","volume":"70","author":"Erickson","year":"2018","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbih.2024.100920_bib22","doi-asserted-by":"crossref","first-page":"2221","DOI":"10.1038\/s41598-022-06034-9","article-title":"Cytokine changes in cerebrospinal fluid and plasma after emergency orthopaedic surgery","volume":"12","author":"Fertleman","year":"2022","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2024.100920_bib23","doi-asserted-by":"crossref","first-page":"1570","DOI":"10.1212\/WNL.0b013e3181a4129a","article-title":"Delirium accelerates cognitive decline in Alzheimer disease","volume":"72","author":"Fong","year":"2009","journal-title":"Neurology"},{"key":"10.1016\/j.bbih.2024.100920_bib24","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1007\/BF02279767","article-title":"Integrity of the blood-CSF barrier in dementia of Alzheimer type: CSF\/serum ratios of albumin and IgG","volume":"240","author":"Frolich","year":"1991","journal-title":"Eur. Arch. Psychiatr. Clin. Neurosci."},{"key":"10.1016\/j.bbih.2024.100920_bib25","doi-asserted-by":"crossref","first-page":"714","DOI":"10.1038\/nm.4340","article-title":"CX3CR1(+) monocytes modulate learning and learning-dependent dendritic spine remodeling via TNF-alpha","volume":"23","author":"Garre","year":"2017","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbih.2024.100920_bib26","article-title":"Measurements below the detection limit","volume":"142","author":"Giskeodegard","year":"2022","journal-title":"Tidsskr. Nor. Laegeforen"},{"key":"10.1016\/j.bbih.2024.100920_bib27","doi-asserted-by":"crossref","DOI":"10.1523\/JNEUROSCI.6361-11.2013","article-title":"Cyclooxygenase-1-dependent prostaglandins mediate susceptibility to systemic inflammation-induced acute cognitive dysfunction","volume":"33","author":"Griffin","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2024.100920_bib28","doi-asserted-by":"crossref","first-page":"3015","DOI":"10.1038\/s41467-021-23111-1","article-title":"Transcriptional signature in microglia associated with Abeta plaque phagocytosis","volume":"12","author":"Grubman","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2024.100920_bib29","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1002\/gps.4720","article-title":"CSF biomarkers in delirium: a systematic review","volume":"33","author":"Hall","year":"2018","journal-title":"Int. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.bbih.2024.100920_bib30","doi-asserted-by":"crossref","first-page":"211","DOI":"10.1186\/s12974-016-0681-9","article-title":"Perioperative cerebrospinal fluid and plasma inflammatory markers after orthopedic surgery","volume":"13","author":"Hirsch","year":"2016","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2024.100920_bib31","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1159\/000443789","article-title":"Blood-cerebrospinal fluid barrier integrity in delirium determined by Q-albumin","volume":"41","author":"Hov","year":"2016","journal-title":"Dement. Geriatr. Cognit. Disord."},{"key":"10.1016\/j.bbih.2024.100920_bib32","doi-asserted-by":"crossref","first-page":"941","DOI":"10.7326\/0003-4819-113-12-941","article-title":"Clarifying confusion: the confusion assessment method. A new method for detection of delirium","volume":"113","author":"Inouye","year":"1990","journal-title":"Ann. Intern. Med."},{"key":"10.1016\/j.bbih.2024.100920_bib33","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","article-title":"Delirium in elderly people","volume":"383","author":"Inouye","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2024.100920_bib34","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1017\/S1041610204000390","article-title":"The Informant Questionnaire on cognitive decline in the elderly (IQCODE): a review","volume":"16","author":"Jorm","year":"2004","journal-title":"Int. Psychogeriatr."},{"key":"10.1016\/j.bbih.2024.100920_bib35","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1097\/00003246-198510000-00009","article-title":"Apache II: a severity of disease classification system","volume":"13","author":"Knaus","year":"1985","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbih.2024.100920_bib36","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.15252\/embr.201541499","article-title":"Central CCL2 signaling onto MCH neurons mediates metabolic and behavioral adaptation to inflammation","volume":"17","author":"Le Thuc","year":"2016","journal-title":"EMBO Rep."},{"key":"10.1016\/j.bbih.2024.100920_bib37","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.immuni.2018.12.012","article-title":"Cell-type-specific interleukin 1 receptor 1 signaling in the brain regulates distinct neuroimmune activities","volume":"50","author":"Liu","year":"2019","journal-title":"Immunity"},{"key":"10.1016\/j.bbih.2024.100920_bib38","doi-asserted-by":"crossref","first-page":"1151","DOI":"10.1111\/j.1532-5415.2011.03428.x","article-title":"Cerebrospinal fluid interleukin-8 levels are higher in people with hip fracture with perioperative delirium than in controls","volume":"59","author":"MacLullich","year":"2011","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbih.2024.100920_bib39","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1001\/jama.2012.6857","article-title":"Postoperative delirium: a 76-year-old woman with delirium following surgery","volume":"308","author":"Marcantonio","year":"2012","journal-title":"JAMA"},{"key":"10.1016\/j.bbih.2024.100920_bib40","doi-asserted-by":"crossref","DOI":"10.1038\/srep15862","article-title":"The Chemokine MIP-1alpha\/CCL3 impairs mouse hippocampal synaptic transmission, plasticity and memory","volume":"5","author":"Marciniak","year":"2015","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2024.100920_bib41","doi-asserted-by":"crossref","first-page":"2822","DOI":"10.1210\/en.2008-1610","article-title":"Altered iron metabolism is part of the choroid plexus response to peripheral inflammation","volume":"150","author":"Marques","year":"2009","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbih.2024.100920_bib42","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1111\/jgs.14238","article-title":"Associations between delirium and preoperative cerebrospinal fluid C-reactive protein, interleukin-6, and interleukin-6 receptor in individuals with acute hip fracture","volume":"64","author":"Neerland","year":"2016","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbih.2024.100920_bib43","doi-asserted-by":"crossref","first-page":"900","DOI":"10.1002\/gps.4233","article-title":"Preoperative risk factors for postoperative delirium following hip fracture repair: a systematic review","volume":"30","author":"Oh","year":"2015","journal-title":"Int. J. Geriatr. Psychiatr."},{"key":"10.1016\/j.bbih.2024.100920_bib44","doi-asserted-by":"crossref","first-page":"4191","DOI":"10.1038\/s41598-019-40544-3","article-title":"Cerebrospinal fluid spermidine, glutamine and putrescine predict postoperative delirium following elective orthopaedic surgery","volume":"9","author":"Pan","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2024.100920_bib45","doi-asserted-by":"crossref","first-page":"23357","DOI":"10.1074\/jbc.M309283200","article-title":"Eotaxin-3\/CCL26 is a natural antagonist for CC chemokine receptors 1 and 5. A human chemokine with a regulatory role","volume":"279","author":"Petkovic","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbih.2024.100920_bib46","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.3233\/JAD-190941","article-title":"Cerebrospinal fluid levels of interleukin-8 in delirium, dementia, and cognitively healthy patients","volume":"73","author":"Sajjad","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2024.100920_bib47","doi-asserted-by":"crossref","first-page":"827","DOI":"10.1001\/jama.1992.03480060073033","article-title":"Risk factors for delirium in hospitalized elderly","volume":"267","author":"Schor","year":"1992","journal-title":"JAMA"},{"key":"10.1016\/j.bbih.2024.100920_bib48","doi-asserted-by":"crossref","first-page":"200","DOI":"10.14336\/AD.2020.0103","article-title":"The interstitial system of the brain in Health and disease","volume":"11","author":"Shetty","year":"2020","journal-title":"Aging Dis"},{"key":"10.1016\/j.bbih.2024.100920_bib49","doi-asserted-by":"crossref","first-page":"520","DOI":"10.1016\/j.toxrep.2021.03.002","article-title":"Increased cytokine expression in the choroid plexus stroma and epithelium in response to endotoxin-induced systemic inflammation in mice","volume":"8","author":"Shimada","year":"2021","journal-title":"Toxicol Rep"},{"key":"10.1016\/j.bbih.2024.100920_bib50","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1016\/j.neuron.2020.08.024","article-title":"Tracking calcium dynamics and immune surveillance at the choroid plexus blood-cerebrospinal fluid interface","volume":"108","author":"Shipley","year":"2020","journal-title":"Neuron"},{"key":"10.1016\/j.bbih.2024.100920_bib51","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41380-019-0403-7","article-title":"Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms","volume":"24","author":"Skelly","year":"2019","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2024.100920_bib52","doi-asserted-by":"crossref","first-page":"1533","DOI":"10.1038\/s41380-019-0403-7","article-title":"Acute transient cognitive dysfunction and acute brain injury induced by systemic inflammation occur by dissociable IL-1-dependent mechanisms","volume":"24","author":"Skelly","year":"2019","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2024.100920_bib53","doi-asserted-by":"crossref","DOI":"10.1371\/annotation\/90c76048-2edd-4315-8404-4d9d8cbd411e","article-title":"A systematic analysis of the peripheral and CNS effects of systemic LPS, IL-1beta, [corrected] TNF-alpha and IL-6 challenges in C57BL\/6 mice","volume":"8","author":"Skelly","year":"2013","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2024.100920_bib54","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.neurobiolaging.2017.06.028","article-title":"CSF\/serum albumin ratio in dementias: a cross-sectional study on 1861 patients","volume":"59","author":"Skillback","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2024.100920_bib55","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1016\/j.bja.2020.12.040","article-title":"Electrophysiological signatures of acute systemic lipopolysaccharide-induced inflammation: potential implications for delirium science","volume":"126","author":"Sultan","year":"2021","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbih.2024.100920_bib56","doi-asserted-by":"crossref","first-page":"219","DOI":"10.1016\/j.bja.2022.01.005","article-title":"Postoperative delirium and changes in the blood-brain barrier, neuroinflammation, and cerebrospinal fluid lactate: a prospective cohort study","volume":"129","author":"Taylor","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbih.2024.100920_bib57","doi-asserted-by":"crossref","first-page":"667","DOI":"10.2119\/molmed.2014.00143","article-title":"Stimulation of the alpha7 nicotinic acetylcholine receptor protects against neuroinflammation after tibia fracture and endotoxemia in mice","volume":"20","author":"Terrando","year":"2015","journal-title":"Mol. Med."},{"key":"10.1016\/j.bbih.2024.100920_bib58","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1186\/s40478-021-01245-z","article-title":"Importance of extracellular vesicle secretion at the blood-cerebrospinal fluid interface in the pathogenesis of Alzheimer's disease","volume":"9","author":"Vandendriessche","year":"2021","journal-title":"Acta Neuropathol Commun"},{"key":"10.1016\/j.bbih.2024.100920_bib59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bbi.2016.03.010","article-title":"The blood-brain barrier in systemic inflammation","volume":"60","author":"Varatharaj","year":"2017","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2024.100920_bib60","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1002\/alz.12941","article-title":"Preclinical and translational models for delirium: recommendations for future research from the NIDUS delirium network","volume":"19","author":"Vasunilashorn","year":"2023","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2024.100920_bib61","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/nature10357","article-title":"The ageing systemic milieu negatively regulates neurogenesis and cognitive function","volume":"477","author":"Villeda","year":"2011","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2024.100920_bib62","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1002\/alz.12064","article-title":"Neurovascular and immune mechanisms that regulate postoperative delirium superimposed on dementia","volume":"16","author":"Wang","year":"2020","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2024.100920_bib63","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1111\/jgs.12612","article-title":"Anticholinergic activity in cerebrospinal fluid and serum in individuals with hip fracture with and without delirium","volume":"62","author":"Watne","year":"2014","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbih.2024.100920_bib64","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1186\/1741-7015-12-63","article-title":"The effect of a pre- and postoperative orthogeriatric service on cognitive function in patients with hip fracture: randomized controlled trial (Oslo Orthogeriatric Trial)","volume":"12","author":"Watne","year":"2014","journal-title":"BMC Med."},{"key":"10.1016\/j.bbih.2024.100920_bib65","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/1742-2094-10-122","article-title":"Preoperative cerebrospinal fluid cytokine levels and the risk of postoperative delirium in elderly hip fracture patients","volume":"10","author":"Westhoff","year":"2013","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2024.100920_bib66","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41572-020-00223-4","article-title":"Delirium","volume":"6","author":"Wilson","year":"2020","journal-title":"Nat. Rev. Dis. Prim."},{"key":"10.1016\/j.bbih.2024.100920_bib67","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1001\/jama.2010.1013","article-title":"Delirium in elderly patients and the risk of postdischarge mortality, institutionalization, and dementia: a meta-analysis","volume":"304","author":"Witlox","year":"2010","journal-title":"JAMA"},{"key":"10.1016\/j.bbih.2024.100920_bib68","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s00401-009-0627-8","article-title":"Choroid plexus: biology and pathology","volume":"119","author":"Wolburg","year":"2010","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbih.2024.100920_bib69","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1186\/1471-2318-12-36","article-title":"The effect of a pre- and post-operative orthogeriatric service on cognitive function in patients with hip fracture. The protocol of the Oslo Orthogeriatrics Trial","volume":"12","author":"Wyller","year":"2012","journal-title":"BMC Geriatr."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624001984?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624001984?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:24:32Z","timestamp":1737739472000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354624001984"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":70,"alternative-id":["S2666354624001984"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100920","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chemokine associations with blood cerebrospinal fluid (CSF) barrier permeability and delirium","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100920","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100920"}}