{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,28]],"date-time":"2026-10-28T02:50:23Z","timestamp":1793155823508,"version":"4.5.0"},"reference-count":190,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbih.2024.100928","type":"journal-article","created":{"date-parts":[[2024,12,24]],"date-time":"2024-12-24T04:28:57Z","timestamp":1735014537000},"page":"100928","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":15,"special_numbering":"C","title":["Interaction between Th17 and central nervous system in multiple sclerosis"],"prefix":"10.1016","volume":"43","author":[{"given":"Shixin","family":"Lai","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yue","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bo","family":"Liu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haiqi","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9739-7686","authenticated-orcid":false,"given":"Kongyang","family":"Ma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib1","doi-asserted-by":"crossref","first-page":"7799","DOI":"10.1038\/s41598-018-26088-y","article-title":"Amelioration of Experimental autoimmune encephalomyelitis and DSS induced colitis by NTG-A-009 through the inhibition of Th1 and Th17 cells differentiation","volume":"8","author":"Acharya","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2024.100928_bib3","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2022.104580","article-title":"CC chemokine receptor 5 antagonist alleviates inflammation by regulating IFN-\u03b3\/IL-10 and STAT4\/Smad 3 signaling in a mouse model of autoimmune encephalomyelitis","volume":"379","author":"Ahmad","year":"2022","journal-title":"Cell. Immunol."},{"key":"10.1016\/j.bbih.2024.100928_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2023.176086","article-title":"MAP kinase inhibitor PD98059 regulates Th1, Th9, Th17, and natural T regulatory cells in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis","volume":"959","author":"Ahmad","year":"2023","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbih.2024.100928_bib5","doi-asserted-by":"crossref","DOI":"10.1016\/j.msard.2023.104658","article-title":"S3I-201, a selective stat3 inhibitor, ameliorates clinical symptoms in a mouse model of experimental autoimmune encephalomyelitis through the regulation of multiple intracellular signalling in Th1, Th17, and treg cells","volume":"73","author":"Ahmad","year":"2023","journal-title":"Mult Scler Relat Disord"},{"issue":"9","key":"10.1016\/j.bbih.2024.100928_bib6","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11092502","article-title":"Auranofin modulates thioredoxin reductase\/nrf2 signaling in peripheral immune cells and the CNS in a mouse model of relapsing-remitting EAE","volume":"11","author":"Al-Kharashi","year":"2023","journal-title":"Biomedicines"},{"issue":"20","key":"10.1016\/j.bbih.2024.100928_bib7","doi-asserted-by":"crossref","DOI":"10.3390\/ijms242015273","article-title":"Histamine H4 receptor antagonist ameliorates the progression of experimental autoimmune encephalomyelitis via regulation of T-cell imbalance","volume":"24","author":"Aldossari","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib8","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines11061511","article-title":"DAPTA, a C-C chemokine receptor 5 (CCR5), leads to the downregulation of Notch\/NF-\u03baB signaling and proinflammatory mediators in CD40(+) cells in experimental autoimmune encephalomyelitis model in SJL\/J mice","volume":"11","author":"Alghibiwi","year":"2023","journal-title":"Biomedicines"},{"issue":"7","key":"10.1016\/j.bbih.2024.100928_bib9","doi-asserted-by":"crossref","DOI":"10.3390\/pharmaceutics13070925","article-title":"Pharmacological inhibition of STAT3 by stattic ameliorates clinical symptoms and reduces autoinflammation in myeloid, lymphoid, and neuronal tissue compartments in relapsing-remitting model of experimental autoimmune encephalomyelitis in SJL\/J mice","volume":"13","author":"Alhazzani","year":"2021","journal-title":"Pharmaceutics"},{"key":"10.1016\/j.bbih.2024.100928_bib200","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.molimm.2022.02.017","article-title":"CCR1 antagonist ameliorates experimental autoimmune encephalomyelitis by inhibition of Th9\/Th22-related markers in the brain and periphery","volume":"144","author":"Al-Mazroua","year":"2022","journal-title":"Molecular Immunology"},{"key":"10.1016\/j.bbih.2024.100928_bib10","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.brainresbull.2023.01.003","article-title":"Mitogen-activated protein kinase inhibitor PD98059 improves neuroimmune dysfunction in experimental autoimmune encephalomyelitis in SJL\/J mice through the inhibition of nuclear factor-kappa B signaling in B cells","volume":"194","author":"Alomar","year":"2023","journal-title":"Brain Res. Bull."},{"issue":"16","key":"10.1016\/j.bbih.2024.100928_bib11","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241612991","article-title":"Histamine H4 receptor agonist, 4-methylhistamine, aggravates disease progression and promotes pro-inflammatory signaling in B cells in an experimental autoimmune encephalomyelitis mouse model","volume":"24","author":"Alsaad","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib12","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1186\/s12974-024-03270-w","article-title":"Coenzyme A fueling with pantethine limits autoreactive T cell pathogenicity in experimental neuroinflammation","volume":"21","author":"Angiari","year":"2024","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2024.100928_bib13","doi-asserted-by":"crossref","DOI":"10.1016\/j.expneurol.2022.113997","article-title":"Cathepsin B inhibitor alleviates Th1, Th17, and Th22 transcription factor signaling dysregulation in experimental autoimmune encephalomyelitis","volume":"351","author":"Ansari","year":"2022","journal-title":"Exp. Neurol."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib14","doi-asserted-by":"crossref","DOI":"10.1016\/j.imbio.2022.152245","article-title":"CCR1 antagonist J-113863 corrects the imbalance of pro- and anti-inflammatory cytokines in a SJL\/J mouse model of relapsing-remitting multiple sclerosis","volume":"227","author":"Ansari","year":"2022","journal-title":"Immunobiology"},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib15","article-title":"BJ-3105, a 6-Alkoxypyridin-3-ol analog, impairs T cell differentiation and prevents experimental autoimmune encephalomyelitis disease progression","volume":"12","author":"Ashour","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib16","doi-asserted-by":"crossref","first-page":"1001","DOI":"10.1084\/jem.20111675","article-title":"B cell depletion therapy ameliorates autoimmune disease through ablation of IL-6-producing B cells","volume":"209","author":"Barr","year":"2012","journal-title":"J. Exp. Med."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2024.100928_bib17","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/S0920-1211(03)00118-9","article-title":"Focal cortical dysplasia and intractable epilepsy in adults: clinical, EEG, imaging, and surgical features","volume":"55","author":"Bautista","year":"2003","journal-title":"Epilepsy Res."},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib18","doi-asserted-by":"crossref","first-page":"1058","DOI":"10.1136\/annrheumdis-2013-204816","article-title":"MOR103, a human monoclonal antibody to granulocyte-macrophage colony-stimulating factor, in the treatment of patients with moderate rheumatoid arthritis: results of a phase Ib\/IIa randomised, double-blind, placebo-controlled, dose-escalation trial","volume":"74","author":"Behrens","year":"2015","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbih.2024.100928_bib19","doi-asserted-by":"crossref","first-page":"28","DOI":"10.1016\/j.bbi.2017.08.001","article-title":"Th17 cells in depression","volume":"69","author":"Beurel","year":"2018","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib20","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000000870","article-title":"Interleukin-26, preferentially produced by T(H)17 lymphocytes, regulates CNS barrier function","volume":"7","author":"Broux","year":"2020","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib21","doi-asserted-by":"crossref","first-page":"791","DOI":"10.1586\/ern.10.38","article-title":"Treating multiple sclerosis with monoclonal antibodies: a 2010 update","volume":"10","author":"Buttmann","year":"2010","journal-title":"Expert Rev. Neurother."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib22","doi-asserted-by":"crossref","first-page":"1800","DOI":"10.4049\/jimmunol.180.3.1800","article-title":"Autocrine regulation of IL-21 production in human T lymphocytes","volume":"180","author":"Caprioli","year":"2008","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib23","doi-asserted-by":"crossref","first-page":"614","DOI":"10.1016\/j.immuni.2020.07.012","article-title":"The conserved non-coding sequences CNS6 and CNS9 control cytokine-induced rorc transcription during T helper 17 cell differentiation","volume":"53","author":"Chang","year":"2020","journal-title":"Immunity"},{"issue":"626","key":"10.1016\/j.bbih.2024.100928_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abj0473","article-title":"DICAM promotes T(H)17 lymphocyte trafficking across the blood-brain barrier during autoimmune neuroinflammation","volume":"14","author":"Charabati","year":"2022","journal-title":"Sci. Transl. Med."},{"issue":"9","key":"10.1016\/j.bbih.2024.100928_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.111741","article-title":"Vitamin B5 rewires Th17 cell metabolism via impeding PKM2 nuclear translocation","volume":"41","author":"Chen","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbih.2024.100928_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.phymed.2023.154917","article-title":"Magnolol as STAT3 inhibitor for treating multiple sclerosis by restricting Th17 cells","volume":"117","author":"Chen","year":"2023","journal-title":"Phytomedicine"},{"key":"10.1016\/j.bbih.2024.100928_bib27","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jaut.2013.08.003","article-title":"IL-27p28 inhibits central nervous system autoimmunity by concurrently antagonizing Th1 and Th17 responses","volume":"50","author":"Chong","year":"2014","journal-title":"J. Autoimmun."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib28","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1186\/s12974-016-0536-4","article-title":"CXCR3 signaling in glial cells ameliorates experimental autoimmune encephalomyelitis by restraining the generation of a pro-Th17 cytokine milieu and reducing CNS-infiltrating Th17 cells","volume":"13","author":"Chung","year":"2016","journal-title":"J. Neuroinflammation"},{"issue":"2","key":"10.1016\/j.bbih.2024.100928_bib29","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.cell.2012.09.016","article-title":"A validated regulatory network for Th17 cell specification","volume":"151","author":"Ciofani","year":"2012","journal-title":"Cell"},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib30","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1038\/ni.2027","article-title":"ROR\u03b3t drives production of the cytokine GM-CSF in helper T cells, which is essential for the effector phase of autoimmune neuroinflammation","volume":"12","author":"Codarri","year":"2011","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib31","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/ana.25927","article-title":"Role of B Cells in multiple sclerosis and related disorders","volume":"89","author":"Comi","year":"2021","journal-title":"Ann. Neurol."},{"issue":"4","key":"10.1016\/j.bbih.2024.100928_bib32","doi-asserted-by":"crossref","first-page":"e117","DOI":"10.1212\/NXI.0000000000000117","article-title":"Randomized phase 1b trial of MOR103, a human antibody to GM-CSF, in multiple sclerosis","volume":"2","author":"Constantinescu","year":"2015","journal-title":"Neurol Neuroimmunol Neuroinflamm"},{"issue":"11","key":"10.1016\/j.bbih.2024.100928_bib33","doi-asserted-by":"crossref","first-page":"6056","DOI":"10.1073\/pnas.1919893117","article-title":"Histone H3K27me3 demethylases regulate human Th17 cell development and effector functions by impacting on metabolism","volume":"117","author":"Cribbs","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib34","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1016\/j.cell.2011.07.033","article-title":"Control of TH17\/treg balance by hypoxia-inducible factor 1","volume":"146","author":"Dang","year":"2011","journal-title":"Cell"},{"key":"10.1016\/j.bbih.2024.100928_bib35","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.650708","article-title":"Baricitinib ameliorates experimental autoimmune encephalomyelitis by modulating the janus kinase\/signal transducer and activator of transcription signaling pathway","volume":"12","author":"Dang","year":"2021","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib36","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1586\/ern.13.17","article-title":"Treating multiple sclerosis with monoclonal antibodies: a 2013 update","volume":"13","author":"Dei\u00df","year":"2013","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bbih.2024.100928_bib37","article-title":"BRD4 expression in microglia supports recruitment of T cells into the CNS and exacerbates EAE","author":"Dey","year":"2024","journal-title":"bioRxiv"},{"issue":"8","key":"10.1016\/j.bbih.2024.100928_bib38","doi-asserted-by":"crossref","first-page":"1599","DOI":"10.1084\/jem.20091663","article-title":"Peroxisome proliferator-activated receptor delta limits the expansion of pathogenic Th cells during central nervous system autoimmunity","volume":"207","author":"Dunn","year":"2010","journal-title":"J. Exp. Med."},{"issue":"8","key":"10.1016\/j.bbih.2024.100928_bib39","doi-asserted-by":"crossref","first-page":"1230","DOI":"10.1038\/s41590-023-01568-0","volume":"24","year":"2023","journal-title":"Nat. Immunol."},{"issue":"18","key":"10.1016\/j.bbih.2024.100928_bib40","doi-asserted-by":"crossref","first-page":"12933","DOI":"10.1074\/jbc.274.18.12933","article-title":"Transforming growth factor-\u03b21 induces interleukin-6 expression via activating protein-1 consisting of JunD homodimers in primary human lung fibroblasts","volume":"274","author":"Eickelberg","year":"1999","journal-title":"J. Biol. Chem."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib41","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1111\/imm.13340","article-title":"Temporal overexpression of IL\u201022 and Reg3\u03b3 differentially impacts the severity of experimental autoimmune encephalomyelitis","volume":"164","author":"Eken","year":"2021","journal-title":"Immunology"},{"issue":"8","key":"10.1016\/j.bbih.2024.100928_bib42","doi-asserted-by":"crossref","first-page":"4957","DOI":"10.4049\/jimmunol.0900735","article-title":"Differential effect of IL-27 on developing versus committed Th17 cells","volume":"183","author":"El-behi","year":"2009","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib43","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1038\/ni.2031","article-title":"The encephalitogenicity of T(H)17 cells is dependent on IL-1- and IL-23-induced production of the cytokine GM-CSF","volume":"12","author":"El-Behi","year":"2011","journal-title":"Nat. Immunol."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib44","doi-asserted-by":"crossref","first-page":"725","DOI":"10.1002\/glia.22637","article-title":"The selective anti-IL17A monoclonal antibody secukinumab (AIN457) attenuates IL17A-induced levels of IL6 in human astrocytes","volume":"62","author":"Elain","year":"2014","journal-title":"Glia"},{"key":"10.1016\/j.bbih.2024.100928_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.jaut.2024.103262","article-title":"Pin1 maintains the effector program of pathogenic Th17 cells in autoimmune neuroinflammation","volume":"147","author":"Fan","year":"2024","journal-title":"J. Autoimmun."},{"issue":"8","key":"10.1016\/j.bbih.2024.100928_bib46","doi-asserted-by":"crossref","first-page":"5245","DOI":"10.4049\/jimmunol.178.8.5245","article-title":"Granulocyte-macrophage colony-stimulating factor (CSF) and macrophage CSF-dependent macrophage phenotypes display differences in cytokine profiles and transcription factor activities: implications for CSF blockade in inflammation","volume":"178","author":"Fleetwood","year":"2007","journal-title":"J. Immunol."},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib48","doi-asserted-by":"crossref","first-page":"1379","DOI":"10.1046\/j.1523-1747.2003.12603.x","article-title":"Interleukin-21 inhibits dendritic cell-mediated T cell activation and induction of contact hypersensitivity in vivo","volume":"121","author":"Foster","year":"2003","journal-title":"J. Invest. Dermatol."},{"key":"10.1016\/j.bbih.2024.100928_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.ejphar.2022.175127","article-title":"Cinnamoyloxy-mammeisin, a coumarin from propolis of stingless bees, attenuates Th17 cell differentiation and autoimmune inflammation via STAT3 inhibition","volume":"929","author":"Franchin","year":"2022","journal-title":"Eur. J. Pharmacol."},{"issue":"2","key":"10.1016\/j.bbih.2024.100928_bib50","doi-asserted-by":"crossref","first-page":"683","DOI":"10.4049\/jimmunol.178.2.683","article-title":"TCR activation eliminates glutamate receptor GluR3 from the cell surface of normal human T cells, via an autocrine\/paracrine granzyme B-mediated proteolytic cleavage","volume":"178","author":"Ganor","year":"2007","journal-title":"J. Immunol."},{"issue":"8","key":"10.1016\/j.bbih.2024.100928_bib51","doi-asserted-by":"crossref","first-page":"1331","DOI":"10.1038\/s41590-023-01553-7","article-title":"Transcription factor EGR2 controls homing and pathogenicity of T(H)17 cells in the central nervous system","volume":"24","author":"Gao","year":"2023","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib52","doi-asserted-by":"crossref","first-page":"11","DOI":"10.2165\/11596920-000000000-00000","article-title":"Monoclonal antibodies and recombinant immunoglobulins for the treatment of multiple sclerosis","volume":"26","author":"Gensicke","year":"2012","journal-title":"CNS Drugs"},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib54","doi-asserted-by":"crossref","first-page":"2445","DOI":"10.1038\/s41467-022-30032-0","article-title":"Versican promotes T helper 17 cytotoxic inflammation and impedes oligodendrocyte precursor cell remyelination","volume":"13","author":"Ghorbani","year":"2022","journal-title":"Nat. Commun."},{"issue":"7318","key":"10.1016\/j.bbih.2024.100928_bib55","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature09447","article-title":"Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling","volume":"467","author":"Ghoreschi","year":"2010","journal-title":"Nature"},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib57","doi-asserted-by":"crossref","first-page":"1680","DOI":"10.1172\/JCI33342","article-title":"The type I IFN induction pathway constrains Th17-mediated autoimmune inflammation in mice","volume":"118","author":"Guo","year":"2008","journal-title":"J. Clin. Invest."},{"key":"10.1016\/j.bbih.2024.100928_bib58","doi-asserted-by":"crossref","DOI":"10.1177\/17562864241239117","article-title":"Treatment algorithms of relapsing multiple sclerosis: an exploration based on the available disease-modifying therapies in China","volume":"17","author":"Guo","year":"2024","journal-title":"Therapeutic Advances in Neurological Disorders"},{"key":"10.1016\/j.bbih.2024.100928_bib59","first-page":"772","volume":"vol. 17","author":"Guo Xiuli","year":"2018"},{"key":"10.1016\/j.bbih.2024.100928_bib60","doi-asserted-by":"crossref","first-page":"3056","DOI":"10.3389\/fimmu.2019.03056","article-title":"Intercellular adhesion molecule-1 (ICAM-1) and ICAM-2 differentially contribute to peripheral activation and CNS entry of autoaggressive Th1 and Th17 cells in experimental autoimmune encephalomyelitis","volume":"10","author":"Haghayegh Jahromi","year":"2019","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib61","doi-asserted-by":"crossref","first-page":"1233","DOI":"10.1142\/S0192415X23500568","article-title":"Total flavonoids of Astragalus inhibit activated CD4[formula: see text] T cells and regulate differentiation of Th17\/Th1\/treg cells in experimental autoimmune encephalomyelitis mice by JAK\/STAT and NF[formula: see text]B signaling pathways","volume":"51","author":"Han","year":"2023","journal-title":"Am. J. Chin. Med."},{"issue":"11","key":"10.1016\/j.bbih.2024.100928_bib62","doi-asserted-by":"crossref","first-page":"1123","DOI":"10.1038\/ni1254","article-title":"Interleukin 17-producing CD4+ effector T cells develop via a lineage distinct from the T helper type 1 and 2 lineages","volume":"6","author":"Harrington","year":"2005","journal-title":"Nat. Immunol."},{"issue":"7","key":"10.1016\/j.bbih.2024.100928_bib63","doi-asserted-by":"crossref","first-page":"4313","DOI":"10.4049\/jimmunol.179.7.4313","article-title":"Cutting edge: an in vivo requirement for STAT3 signaling in TH17 development and TH17-dependent autoimmunity","volume":"179","author":"Harris","year":"2007","journal-title":"J. Immunol."},{"issue":"36","key":"10.1016\/j.bbih.2024.100928_bib64","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2023174118","article-title":"Bcl6 controls meningeal Th17-B cell interaction in murine neuroinflammation","volume":"118","author":"Hartlehnert","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib65","doi-asserted-by":"crossref","first-page":"774","DOI":"10.1007\/s13311-022-01214-x","article-title":"Antibody therapies for progressive multiple sclerosis and for promoting repair","volume":"19","author":"Havla","year":"2022","journal-title":"Neurotherapeutics"},{"issue":"7","key":"10.1016\/j.bbih.2024.100928_bib66","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1007\/s00415-016-8128-x","article-title":"Activity of secukinumab, an anti-IL-17A antibody, on brain lesions in RRMS: results from a randomized, proof-of-concept study","volume":"263","author":"Havrdov\u00e1","year":"2016","journal-title":"J. Neurol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib67","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms8216","article-title":"The CREB\/CRTC2 pathway modulates autoimmune disease by promoting Th17 differentiation","volume":"6","author":"Hernandez","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2024.100928_bib68","doi-asserted-by":"crossref","DOI":"10.3389\/fnut.2023.1146748","article-title":"Gut microbiome-modulated dietary strategies in EAE and multiple sclerosis","volume":"10","author":"Hoffman","year":"2023","journal-title":"Front. Nutr."},{"key":"10.1016\/j.bbih.2024.100928_bib69","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.615898","article-title":"Interleukin-19 abrogates experimental autoimmune encephalomyelitis by attenuating antigen-presenting cell activation","volume":"12","author":"Horiuchi","year":"2021","journal-title":"Front. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib70","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1186\/s13104-020-05427-1","article-title":"Epigenetic mechanisms shape the underlining expression regulatory mechanisms of the STAT3 in multiple sclerosis disease","volume":"13","author":"Hosseini","year":"2020","journal-title":"BMC Res. Notes"},{"key":"10.1016\/j.bbih.2024.100928_bib71","doi-asserted-by":"crossref","DOI":"10.1016\/j.lfs.2021.119395","article-title":"Ruxolitinib attenuates experimental autoimmune encephalomyelitis (EAE) development as animal models of multiple sclerosis (MS)","volume":"276","author":"Hosseini","year":"2021","journal-title":"Life Sci."},{"issue":"4","key":"10.1016\/j.bbih.2024.100928_bib72","doi-asserted-by":"crossref","first-page":"1023","DOI":"10.1096\/fj.09-141978","article-title":"Cellular mechanisms of IL-17-induced blood-brain barrier disruption","volume":"24","author":"Huppert","year":"2010","journal-title":"Faseb. J."},{"key":"10.1016\/j.bbih.2024.100928_bib73","doi-asserted-by":"crossref","first-page":"3075","DOI":"10.3389\/fimmu.2018.03075","article-title":"Pregnancy epigenetic signature in T helper 17 and T regulatory cells in multiple sclerosis","volume":"9","author":"Iannello","year":"2018","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib74","doi-asserted-by":"crossref","first-page":"1284","DOI":"10.1016\/j.immuni.2016.05.015","article-title":"The MicroRNA-183-96-182 cluster promotes T helper 17 cell pathogenicity by negatively regulating transcription factor Foxo 1 expression","volume":"44","author":"Ichiyama","year":"2016","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib75","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1093\/brain\/awad286","article-title":"ALCAM on human oligodendrocytes mediates CD4 T cell adhesion","volume":"147","author":"Jamann","year":"2024","journal-title":"Brain"},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib76","doi-asserted-by":"crossref","DOI":"10.1038\/s41467-018-03852-2","article-title":"Epigenetic activation during T helper 17 cell differentiation is mediated by Tripartite motif containing 28","volume":"9","author":"Jiang","year":"2018","journal-title":"Nat. Commun."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib77","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1210\/me.2009-0507","article-title":"Structural basis for hydroxycholesterols as natural ligands of orphan nuclear receptor ROR\u03b3","volume":"24","author":"Jin","year":"2010","journal-title":"Mol. Endocrinol."},{"issue":"10","key":"10.1016\/j.bbih.2024.100928_bib78","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1038\/nn.3505","article-title":"Act1 mediates IL-17-induced EAE pathogenesis selectively in NG2+ glial cells","volume":"16","author":"Kang","year":"2013","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbih.2024.100928_bib79","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmthera.2023.108411","article-title":"Lipid metabolism in Th17 cell function","volume":"245","author":"Kanno","year":"2023","journal-title":"Pharmacol. Therapeut."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib80","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1016\/S1474-4422(18)30069-3","article-title":"Effect of natalizumab on disease progression in secondary progressive multiple sclerosis (ASCEND): a phase 3, randomised, double-blind, placebo-controlled trial with an open-label extension","volume":"17","author":"Kapoor","year":"2018","journal-title":"Lancet Neurol."},{"issue":"4","key":"10.1016\/j.bbih.2024.100928_bib81","doi-asserted-by":"crossref","DOI":"10.1101\/cshperspect.a029025","article-title":"Effector T cells in multiple sclerosis","volume":"8","author":"Kaskow","year":"2018","journal-title":"Cold Spring Harb Perspect Med"},{"issue":"9","key":"10.1016\/j.bbih.2024.100928_bib82","doi-asserted-by":"crossref","first-page":"1671","DOI":"10.1185\/030079906X120931","article-title":"A phase I trial of an interleukin-12\/23 monoclonal antibody in relapsing multiple sclerosis","volume":"22","author":"Kasper","year":"2006","journal-title":"Curr. Med. Res. Opin."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib83","first-page":"296","article-title":"Identifying CNS-colonizing T cells as potential therapeutic targets to prevent progression of multiple sclerosis","volume":"2","author":"Kaufmann","year":"2021","journal-title":"M\u00e9d."},{"issue":"10","key":"10.1016\/j.bbih.2024.100928_bib84","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1038\/nm1651","article-title":"Human TH17 lymphocytes promote blood-brain barrier disruption and central nervous system inflammation","volume":"13","author":"Kebir","year":"2007","journal-title":"Nat. Med."},{"issue":"7","key":"10.1016\/j.bbih.2024.100928_bib85","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.immuni.2023.04.013","article-title":"Interleukin-3 coordinates glial-peripheral immune crosstalk to incite multiple sclerosis","volume":"56","author":"Kiss","year":"2023","journal-title":"Immunity"},{"issue":"11","key":"10.1016\/j.bbih.2024.100928_bib86","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/s41582-021-00556-y","article-title":"Apparent changes in the epidemiology and severity of multiple sclerosis","volume":"17","author":"Koch-Henriksen","year":"2021","journal-title":"Nat. Rev. Neurol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib87","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.cellimm.2013.11.002","article-title":"Selective CB2 receptor activation ameliorates EAE by reducing Th17 differentiation and immune cell accumulation in the CNS","volume":"287","author":"Kong","year":"2014","journal-title":"Cell. Immunol."},{"issue":"11","key":"10.1016\/j.bbih.2024.100928_bib88","doi-asserted-by":"crossref","first-page":"1869","DOI":"10.1002\/art.41019","article-title":"Glutaminase 1 inhibition reduces glycolysis and ameliorates lupus\u2010like disease in MRL\/lpr mice and experimental autoimmune encephalomyelitis","volume":"71","author":"Kono","year":"2019","journal-title":"Arthritis Rheumatol."},{"issue":"7152","key":"10.1016\/j.bbih.2024.100928_bib89","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nature05970","article-title":"IL-21 initiates an alternative pathway to induce proinflammatory TH17 cells","volume":"448","author":"Korn","year":"2007","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2024.100928_bib90","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.msard.2016.11.006","article-title":"IL-17 signalling in astrocytes promotes glutamate excitotoxicity: indications for the link between inflammatory and neurodegenerative events in multiple sclerosis","volume":"11","author":"Kostic","year":"2017","journal-title":"Mult Scler Relat Disord"},{"issue":"12","key":"10.1016\/j.bbih.2024.100928_bib91","doi-asserted-by":"crossref","first-page":"8098","DOI":"10.4049\/jimmunol.179.12.8098","article-title":"IL-22 is expressed by Th17 cells in an IL-23-dependent fashion, but not required for the development of autoimmune encephalomyelitis","volume":"179","author":"Kreymborg","year":"2007","journal-title":"J. Immunol."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib92","doi-asserted-by":"crossref","first-page":"1423","DOI":"10.4049\/jimmunol.179.3.1423","article-title":"Cutting edge: opposite effects of IL-1 and IL-2 on the regulation of IL-17+ T cell pool IL-1 subverts IL-2-mediated suppression","volume":"179","author":"Kryczek","year":"2007","journal-title":"J. Immunol."},{"issue":"Pt 10","key":"10.1016\/j.bbih.2024.100928_bib94","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1093\/brain\/aws212","article-title":"Melanoma cell adhesion molecule identifies encephalitogenic T lymphocytes and promotes their recruitment to the central nervous system","volume":"135","author":"Larochelle","year":"2012","journal-title":"Brain"},{"issue":"34","key":"10.1016\/j.bbih.2024.100928_bib95","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2025813118","article-title":"Pro-inflammatory T helper 17 directly harms oligodendrocytes in neuroinflammation","volume":"118","author":"Larochelle","year":"2021","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib96","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.immuni.2007.02.009","article-title":"Interleukin-2 signaling via STAT5 constrains T helper 17 cell generation","volume":"26","author":"Laurence","year":"2007","journal-title":"Immunity"},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib97","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1186\/s12987-023-00441-4","article-title":"The choroid plexus acts as an immune cell reservoir and brain entry site in experimental autoimmune encephalomyelitis","volume":"20","author":"Lazarevic","year":"2023","journal-title":"Fluids Barriers CNS"},{"issue":"10","key":"10.1016\/j.bbih.2024.100928_bib98","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1038\/ni.2416","article-title":"Induction and molecular signature of pathogenic TH17 cells","volume":"13","author":"Lee","year":"2012","journal-title":"Nat. Immunol."},{"issue":"17","key":"10.1016\/j.bbih.2024.100928_bib99","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.91663","article-title":"IL-23R-activated STAT3\/STAT4 is essential for Th1\/Th17-mediated CNS autoimmunity","volume":"2","author":"Lee","year":"2017","journal-title":"JCI Insight"},{"key":"10.1016\/j.bbih.2024.100928_bib100","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.bbrc.2022.06.081","article-title":"IL-6 activates pathologic Th17 cell via STAT 3 phosphorylation in inflammatory joint of Ankylosing Spondylitis","volume":"620","author":"Lee","year":"2022","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib101","article-title":"IL-10 engages macrophages to shift Th17 cytokine dependency and pathogenicity during T-cell-mediated colitis","volume":"6","author":"Li","year":"2015","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2024.100928_bib102","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.msard.2017.09.003","article-title":"Levels of peripheral Th17 cells and serum Th17-related cytokines in patients with multiple sclerosis: a meta-analysis","volume":"18","author":"Li","year":"2017","journal-title":"Mult Scler Relat Disord"},{"key":"10.1016\/j.bbih.2024.100928_bib103","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2020.590884","article-title":"Rapamycin alleviates the symptoms of multiple sclerosis in experimental autoimmune encephalomyelitis (EAE) through mediating the TAM-TLRs-SOCS pathway","volume":"11","author":"Li","year":"2020","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbih.2024.100928_bib104","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2022.1028653","article-title":"Glial cells and neurologic autoimmune disorders","volume":"16","author":"Li","year":"2022","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbih.2024.100928_bib105","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1354074","article-title":"Formyl peptide receptor 2 regulates dendritic cell metabolism and Th17 cell differentiation during neuroinflammation","volume":"15","author":"Lim","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2024.100928_bib106","doi-asserted-by":"crossref","first-page":"3551","DOI":"10.1038\/ncomms4551","article-title":"Bhlhe40 controls cytokine production by T cells and is essential for pathogenicity in autoimmune neuroinflammation","volume":"5","author":"Lin","year":"2014","journal-title":"Nat. Commun."},{"issue":"2","key":"10.1016\/j.bbih.2024.100928_bib107","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1084\/jem.20150568","article-title":"IL-1-induced Bhlhe40 identifies pathogenic T helper cells in a model of autoimmune neuroinflammation","volume":"213","author":"Lin","year":"2016","journal-title":"J. Exp. Med."},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib109","doi-asserted-by":"crossref","first-page":"505","DOI":"10.1093\/jmcb\/mjv022","article-title":"The histone H3 lysine-27 demethylase Jmjd3 plays a critical role in specific regulation of Th17 cell differentiation","volume":"7","author":"Liu","year":"2015","journal-title":"J. Mol. Cell Biol."},{"key":"10.1016\/j.bbih.2024.100928_bib110","doi-asserted-by":"crossref","DOI":"10.3389\/fncel.2021.679413","article-title":"IL-17 inhibits oligodendrocyte progenitor cell proliferation and differentiation by increasing K(+) channel Kv1.3","volume":"15","author":"Liu","year":"2021","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbih.2024.100928_bib111","doi-asserted-by":"crossref","DOI":"10.1016\/j.cellimm.2022.104500","article-title":"Artemisinin derivative TPN10466 suppresses immune cell migration and Th1\/Th17 differentiation to ameliorate disease severity in experimental autoimmune encephalomyelitis","volume":"373","author":"Liu","year":"2022","journal-title":"Cell. Immunol."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib112","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1586\/14737175.9.3.319","article-title":"Why did IL-12\/IL-23 antibody therapy fail in multiple sclerosis?","volume":"9","author":"Longbrake","year":"2009","journal-title":"Expert Rev. Neurother."},{"key":"10.1016\/j.bbih.2024.100928_bib113","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/978-1-4615-4253-7_8","article-title":"Phosphorylation-dependent prolyl isomerization: a novel cell cycle regulatory mechanism","volume":"4","author":"Lu","year":"2000","journal-title":"Prog. Cell Cycle Res."},{"issue":"4","key":"10.1016\/j.bbih.2024.100928_bib114","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1016\/j.cytogfr.2014.07.013","article-title":"IL-17 and related cytokines involved in the pathology and immunotherapy of multiple sclerosis: current and future developments","volume":"25","author":"Luchtman","year":"2014","journal-title":"Cytokine Growth Factor Rev."},{"issue":"19","key":"10.1016\/j.bbih.2024.100928_bib116","doi-asserted-by":"crossref","first-page":"17125","DOI":"10.1074\/jbc.M109250200","article-title":"CD40 induces interleukin-6 gene transcription in dendritic cells","volume":"277","author":"Mann","year":"2002","journal-title":"J. Biol. Chem."},{"issue":"20","key":"10.1016\/j.bbih.2024.100928_bib117","doi-asserted-by":"crossref","first-page":"2078","DOI":"10.1001\/jama.2022.14236","article-title":"What is multiple sclerosis?","volume":"328","author":"Marcus","year":"2022","journal-title":"JAMA"},{"issue":"9","key":"10.1016\/j.bbih.2024.100928_bib118","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/S1474-4422(08)70174-1","article-title":"Neutralisation of IL12 p40 or IL23 p40 does not block inflammation in multiple sclerosis","volume":"7","author":"Martin","year":"2008","journal-title":"Lancet Neurol."},{"issue":"12","key":"10.1016\/j.bbih.2024.100928_bib119","doi-asserted-by":"crossref","DOI":"10.3390\/cells13121042","article-title":"A camelid-derived STAT-specific nanobody inhibits neuroinflammation and ameliorates experimental autoimmune encephalomyelitis (EAE)","volume":"13","author":"Mbanefo","year":"2024","journal-title":"Cells"},{"issue":"4","key":"10.1016\/j.bbih.2024.100928_bib120","doi-asserted-by":"crossref","first-page":"524","DOI":"10.1016\/j.cmet.2020.08.002","article-title":"The role of HIF in immunity and inflammation","volume":"32","author":"McGettrick","year":"2020","journal-title":"Cell Metabol."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib121","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1002\/glia.22307","article-title":"Regulation of CCL20 expression in astrocytes by IL-6 and IL-17","volume":"60","author":"Meares","year":"2012","journal-title":"Glia"},{"issue":"2","key":"10.1016\/j.bbih.2024.100928_bib122","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pbio.3002000","article-title":"The activity of the aryl hydrocarbon receptor in T cells tunes the gut microenvironment to sustain autoimmunity and neuroinflammation","volume":"21","author":"Merchak","year":"2023","journal-title":"PLoS Biol."},{"issue":"2","key":"10.1016\/j.bbih.2024.100928_bib124","doi-asserted-by":"crossref","first-page":"392","DOI":"10.1016\/j.celrep.2016.05.088","article-title":"RBPJ controls development of pathogenic Th17 cells by regulating IL-23 receptor expression","volume":"16","author":"Meyer Zu Horste","year":"2016","journal-title":"Cell Rep."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib125","doi-asserted-by":"crossref","first-page":"38","DOI":"10.1038\/s41577-022-00746-9","article-title":"IL-17 and IL-17-producing cells in protection versus pathology","volume":"23","author":"Mills","year":"2023","journal-title":"Nat. Rev. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib126","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-63877-0","article-title":"Myelin oligodendrocyte glycoprotein reactive Th17 cells drive Janus Kinase 1 dependent transcriptional reprogramming in astrocytes and alter cell surface cytokine receptor profiles during experimental autoimmune encephalomyelitis","volume":"14","author":"Milne","year":"2024","journal-title":"Sci. Rep."},{"issue":"22","key":"10.1016\/j.bbih.2024.100928_bib127","doi-asserted-by":"crossref","first-page":"12269","DOI":"10.1073\/pnas.1918196117","article-title":"Activin-A limits Th17 pathogenicity and autoimmune neuroinflammation via CD39 and CD73 ectonucleotidases and Hif1-alpha-dependent pathways","volume":"117","author":"Morianos","year":"2020","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib128","doi-asserted-by":"crossref","first-page":"102","DOI":"10.15252\/embj.201694615","article-title":"IL\u20101 signaling is critical for expansion but not generation of autoreactive GM\u2010CSF+Th17 cells","volume":"36","author":"Mufazalov","year":"2016","journal-title":"EMBO J."},{"issue":"4","key":"10.1016\/j.bbih.2024.100928_bib129","doi-asserted-by":"crossref","first-page":"641","DOI":"10.1016\/j.bbi.2010.01.014","article-title":"Infiltration of Th1 and Th17 cells and activation of microglia in the CNS during the course of experimental autoimmune encephalomyelitis","volume":"24","author":"Murphy","year":"2010","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.bbih.2024.100928_bib130","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.4049\/jimmunol.0900568","article-title":"IL-27 is a key regulator of IL-10 and IL-17 production by human CD4+ T cells","volume":"183","author":"Murugaiyan","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbih.2024.100928_bib131","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2022.108703","article-title":"Acetyl-11-keto-\u03b2-boswellic acid improves clinical symptoms through modulation of Nrf2 and NF-\u03baB pathways in SJL\/J mouse model of experimental autoimmune encephalomyelitis","volume":"107","author":"Nadeem","year":"2022","journal-title":"Int. Immunopharm."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib132","doi-asserted-by":"crossref","first-page":"427","DOI":"10.2741\/e777","article-title":"Genes associated with T helper 17 cell differentiation and function","volume":"8","author":"Nalbant","year":"2016","journal-title":"Front. Biosci."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib133","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/s12987-019-0165-2","article-title":"Human CD4(+) T cell subsets differ in their abilities to cross endothelial and epithelial brain barriers in vitro","volume":"17","author":"Nishihara","year":"2020","journal-title":"Fluids Barriers CNS"},{"issue":"12","key":"10.1016\/j.bbih.2024.100928_bib134","doi-asserted-by":"crossref","first-page":"4334","DOI":"10.1093\/brain\/awac019","article-title":"Intrinsic blood-brain barrier dysfunction contributes to multiple sclerosis pathogenesis","volume":"145","author":"Nishihara","year":"2022","journal-title":"Brain"},{"issue":"241","key":"10.1016\/j.bbih.2024.100928_bib135","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3008706","article-title":"IL-17 and GM-CSF expression are antagonistically regulated by human T helper cells","volume":"6","author":"Noster","year":"2014","journal-title":"Sci. Transl. Med."},{"issue":"9625","key":"10.1016\/j.bbih.2024.100928_bib136","doi-asserted-by":"crossref","first-page":"1675","DOI":"10.1016\/S0140-6736(08)60726-6","article-title":"Efficacy and safety of ustekinumab, a human interleukin-12\/23 monoclonal antibody, in patients with psoriasis: 52-week results from a randomised, double-blind, placebo-controlled trial (PHOENIX 2)","volume":"371","author":"Papp","year":"2008","journal-title":"Lancet"},{"issue":"88","key":"10.1016\/j.bbih.2024.100928_bib137","doi-asserted-by":"crossref","DOI":"10.1126\/sciimmunol.adg7597","article-title":"Integrin alpha 3 promotes T(H)17 cell polarization and extravasation during autoimmune neuroinflammation","volume":"8","author":"Park","year":"2023","journal-title":"Sci Immunol"},{"key":"10.1016\/j.bbih.2024.100928_bib138","doi-asserted-by":"crossref","first-page":"32","DOI":"10.3389\/fnsys.2012.00032","article-title":"Histamine and neuroinflammation: insights from murine experimental autoimmune encephalomyelitis","volume":"6","author":"Passani","year":"2012","journal-title":"Front. Syst. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib139","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-015-0335-3","article-title":"Interleukin-22 is increased in multiple sclerosis patients and targets astrocytes","volume":"12","author":"Perriard","year":"2015","journal-title":"J. Neuroinflammation"},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib140","doi-asserted-by":"crossref","DOI":"10.1186\/s12974-017-0978-3","article-title":"Effectors of Th1 and Th17 cells act on astrocytes and augment their neuroinflammatory properties","volume":"14","author":"Prajeeth","year":"2017","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2024.100928_bib141","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1016\/j.ejphar.2015.03.042","article-title":"Animal models of multiple sclerosis","volume":"759","author":"Procaccini","year":"2015","journal-title":"Eur. J. Pharmacol."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib142","doi-asserted-by":"crossref","first-page":"1855","DOI":"10.4049\/jimmunol.0903853","article-title":"Regulation of Th1 and Th17 cell differentiation and amelioration of experimental autoimmune encephalomyelitis by natural product compound berberine","volume":"185","author":"Qin","year":"2010","journal-title":"J. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib143","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1007\/s12264-023-01094-x","article-title":"TREM-2 drives development of multiple sclerosis by promoting pathogenic Th17 polarization","volume":"40","author":"Qu","year":"2024","journal-title":"Neurosci. Bull."},{"key":"10.1016\/j.bbih.2024.100928_bib144","doi-asserted-by":"crossref","DOI":"10.1155\/2013\/709493","article-title":"Efficacy of fish oil on serum of TNF \u03b1 , IL-1 \u03b2 , and IL-6 oxidative stress markers in multiple sclerosis treated with interferon beta-1b","volume":"2013","author":"Ramirez-Ramirez","year":"2013","journal-title":"Oxid. Med. Cell. Longev."},{"issue":"11","key":"10.1016\/j.bbih.2024.100928_bib145","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1002\/eji.202149674","article-title":"IL-3 regulates the differentiation of pathogenic Th17 cells","volume":"52","author":"Rani","year":"2022","journal-title":"Eur. J. Immunol."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib146","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1038\/ni.1716","article-title":"C-C chemokine receptor 6-regulated entry of TH-17 cells into the CNS through the choroid plexus is required for the initiation of EAE","volume":"10","author":"Reboldi","year":"2009","journal-title":"Nat. Immunol."},{"issue":"9","key":"10.1016\/j.bbih.2024.100928_bib147","article-title":"A fully humanized IgG-like bispecific antibody for effective dual targeting of CXCR3 and CCR6","volume":"12","author":"Richard","year":"2017","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2024.100928_bib148","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/B978-0-444-52001-2.00008-X","article-title":"The experimental autoimmune encephalomyelitis (EAE) model of MS: utility for understanding disease pathophysiology and treatment","volume":"122","author":"Robinson","year":"2014","journal-title":"Handb. Clin. Neurol."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib149","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1002\/glia.22783","article-title":"IL-17A activates ERK1\/2 and enhances differentiation of oligodendrocyte progenitor cells","volume":"63","author":"Rodgers","year":"2015","journal-title":"Glia"},{"key":"10.1016\/j.bbih.2024.100928_bib150","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2018.03036","article-title":"Metabolic checkpoints in differentiation of helper T cells in tissue inflammation","volume":"9","author":"Roy","year":"2019","journal-title":"Front. Immunol."},{"issue":"2","key":"10.1016\/j.bbih.2024.100928_bib151","doi-asserted-by":"crossref","first-page":"250","DOI":"10.1016\/j.cmet.2020.01.006","article-title":"Methionine metabolism shapes T helper cell responses through regulation of epigenetic reprogramming","volume":"31","author":"Roy","year":"2020","journal-title":"Cell Metabol."},{"issue":"4","key":"10.1016\/j.bbih.2024.100928_bib152","doi-asserted-by":"crossref","first-page":"2559","DOI":"10.1074\/jbc.M308809200","article-title":"Functional cooperation between interleukin-17 and tumor necrosis factor-\u03b1 is mediated by CCAAT\/Enhancer-binding protein family members","volume":"279","author":"Ruddy","year":"2004","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbih.2024.100928_bib153","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.bbrc.2022.11.088","article-title":"CCL20\/CCR6 chemokine signaling is not essential for pathogenesis in an experimental autoimmune encephalomyelitis mouse model of multiple sclerosis","volume":"641","author":"Sachi","year":"2023","journal-title":"Biochem. Biophys. Res. Commun."},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib154","doi-asserted-by":"crossref","DOI":"10.1212\/WNL.0000000000209135","article-title":"Investigating the prevalence of comorbidity in multiple sclerosis clinical trial populations","volume":"102","author":"Salter","year":"2024","journal-title":"Neurology"},{"issue":"7","key":"10.1016\/j.bbih.2024.100928_bib155","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1007\/s00011-018-1153-8","article-title":"Prostaglandin E2 and IL-23 interconnects STAT3 and RoRgamma pathways to initiate Th17 CD4(+) T-cell development during rheumatoid arthritis","volume":"67","author":"Samuels","year":"2018","journal-title":"Inflamm. Res."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib156","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1007\/s40265-015-0359-0","article-title":"Secukinumab: first global approval","volume":"75","author":"Sanford","year":"2015","journal-title":"Drugs"},{"key":"10.1016\/j.bbih.2024.100928_bib157","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2021.637829","article-title":"Role of the IL-23\/IL-17 pathway in rheumatic diseases: an overview","volume":"12","author":"Schinocca","year":"2021","journal-title":"Front. Immunol."},{"issue":"7253","key":"10.1016\/j.bbih.2024.100928_bib158","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1038\/nature08114","article-title":"The AP-1 transcription factor Batf controls T(H)17 differentiation","volume":"460","author":"Schraml","year":"2009","journal-title":"Nature"},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib159","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1186\/s12974-019-1500-x","article-title":"Contribution of LTi and T(H)17 cells to B cell aggregate formation in the central nervous system in a mouse model of multiple sclerosis","volume":"16","author":"Schropp","year":"2019","journal-title":"J. Neuroinflammation"},{"issue":"9","key":"10.1016\/j.bbih.2024.100928_bib160","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1016\/S1474-4422(08)70173-X","article-title":"Repeated subcutaneous injections of IL12\/23 p40 neutralising antibody, ustekinumab, in patients with relapsing-remitting multiple sclerosis: a phase II, double-blind, placebo-controlled, randomised, dose-ranging study","volume":"7","author":"Segal","year":"2008","journal-title":"Lancet Neurol."},{"issue":"7","key":"10.1016\/j.bbih.2024.100928_bib161","doi-asserted-by":"crossref","first-page":"1215","DOI":"10.1002\/glia.24148","article-title":"The roles of microglia and astrocytes in phagocytosis and myelination: insights from the cuprizone model of multiple sclerosis","volume":"70","author":"Sen","year":"2022","journal-title":"Glia"},{"issue":"26","key":"10.1016\/j.bbih.2024.100928_bib162","doi-asserted-by":"crossref","first-page":"9041","DOI":"10.1073\/pnas.0802218105","article-title":"IL-6 blockade inhibits the induction of myelin antigen-specific Th17 cells and Th1 cells in experimental autoimmune encephalomyelitis","volume":"105","author":"Serada","year":"2008","journal-title":"Proc. Natl. Acad. Sci. USA"},{"issue":"7","key":"10.1016\/j.bbih.2024.100928_bib163","doi-asserted-by":"crossref","first-page":"1367","DOI":"10.1084\/jem.20110278","article-title":"HIF1\u03b1\u2013dependent glycolytic pathway orchestrates a metabolic checkpoint for the differentiation of TH17 and Treg cells","volume":"208","author":"Shi","year":"2011","journal-title":"J. Exp. Med."},{"key":"10.1016\/j.bbih.2024.100928_bib164","article-title":"Th17 cells and inflammation in neurological disorders: possible mechanisms of action","volume":"13","author":"Shi","year":"2022","journal-title":"Front. Immunol."},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib165","doi-asserted-by":"crossref","first-page":"1898","DOI":"10.1016\/j.celrep.2020.01.022","article-title":"Mitochondrial oxidative phosphorylation regulates the fate decision between pathogenic Th17 and regulatory T cells","volume":"30","author":"Shin","year":"2020","journal-title":"Cell Rep."},{"issue":"8","key":"10.1016\/j.bbih.2024.100928_bib166","doi-asserted-by":"crossref","DOI":"10.1084\/jem.20212443","article-title":"IL-24 intrinsically regulates Th17 cell pathogenicity in mice","volume":"219","author":"Sie","year":"2022","journal-title":"J. Exp. Med."},{"issue":"3","key":"10.1016\/j.bbih.2024.100928_bib167","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1016\/j.immuni.2010.08.018","article-title":"In vivo imaging of partially reversible th17 cell-induced neuronal dysfunction in the course of encephalomyelitis","volume":"33","author":"Siffrin","year":"2010","journal-title":"Immunity"},{"issue":"8","key":"10.1016\/j.bbih.2024.100928_bib168","doi-asserted-by":"crossref","first-page":"941","DOI":"10.1007\/s40264-019-00799-1","article-title":"Established and emerging immunological complications of biological therapeutics in multiple sclerosis","volume":"42","author":"Soleimani","year":"2019","journal-title":"Drug Saf."},{"key":"10.1016\/j.bbih.2024.100928_bib169","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2024.109898","article-title":"Th17 cell promotes apoptosis of IL-23R+ neurons in experimental autoimmune encephalomyelitis","volume":"259","author":"Sonar","year":"2024","journal-title":"Clin. Immunol."},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib170","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1189\/jlb.0905503","article-title":"IL-21 enhances SOCS gene expression and inhibits LPS-induced cytokine production in human monocyte-derived dendritic cells","volume":"79","author":"Strengell","year":"2006","journal-title":"J. Leukoc. Biol."},{"issue":"9","key":"10.1016\/j.bbih.2024.100928_bib171","doi-asserted-by":"crossref","first-page":"5948","DOI":"10.4049\/jimmunol.181.9.5948","article-title":"IL-23 promotes maintenance but not commitment to the Th17 lineage","volume":"181","author":"Stritesky","year":"2008","journal-title":"J. Immunol."},{"issue":"9","key":"10.1016\/j.bbih.2024.100928_bib172","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1038\/ni1376","article-title":"Interleukin 27 negatively regulates the development of interleukin 17-producing T helper cells during chronic inflammation of the central nervous system","volume":"7","author":"Stumhofer","year":"2006","journal-title":"Nat. Immunol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib173","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-024-61508-2","article-title":"Astroglial connexin 43 is a novel therapeutic target for chronic multiple sclerosis model","volume":"14","author":"Takase","year":"2024","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bbih.2024.100928_bib174","doi-asserted-by":"crossref","first-page":"1853","DOI":"10.1084\/jem.20170779","article-title":"Trim33 mediates the proinflammatory function of Th17 cells","volume":"215","author":"Tanaka","year":"2018","journal-title":"J. Exp. Med."},{"issue":"10","key":"10.1016\/j.bbih.2024.100928_bib175","article-title":"Amelioration of experimental autoimmune encephalomyelitis by Plumbagin through down-regulation of JAK-STAT and NF-\u03baB signaling pathways","volume":"6","author":"Tansey","year":"2011","journal-title":"PLoS One"},{"issue":"10125","key":"10.1016\/j.bbih.2024.100928_bib176","doi-asserted-by":"crossref","first-page":"1000","DOI":"10.1016\/S0140-6736(18)30565-8","article-title":"End of the road for daclizumab in multiple sclerosis","volume":"391","author":"The","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2024.100928_bib177","article-title":"Incidence of multiple sclerosis in China: a nationwide hospital-based study","volume":"1","author":"Tian","year":"2020","journal-title":"Lancet Reg Health West Pac"},{"key":"10.1016\/j.bbih.2024.100928_bib178","doi-asserted-by":"crossref","DOI":"10.1111\/1346-8138.17143","article-title":"Risk of multiple sclerosis in patients with psoriasis receiving anti-IL-17 agents: a case-based review","author":"Tsiogkas","year":"2024","journal-title":"J. Dermatol."},{"issue":"4","key":"10.1016\/j.bbih.2024.100928_bib179","doi-asserted-by":"crossref","first-page":"417","DOI":"10.2174\/1871530322666220921160930","article-title":"Targeting T cell metabolism as a novel approach for treatment of MS: with a focus on PFKFB3 inhibitors","volume":"23","author":"Vakili","year":"2023","journal-title":"Endocr. Metab. Immune Disord. - Drug Targets"},{"issue":"11","key":"10.1016\/j.bbih.2024.100928_bib180","article-title":"Increase in Th17 and T-reg lymphocytes and decrease of IL22 correlate with the recovery phase of acute EAE in rat","volume":"6","author":"Villoslada","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib181","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1111\/j.1600-065X.2012.01152.x","article-title":"mTOR, metabolism, and the regulation of T\u2010cell differentiation and function","volume":"249","author":"Waickman","year":"2012","journal-title":"Immunol. Rev."},{"issue":"14","key":"10.1016\/j.bbih.2024.100928_bib182","doi-asserted-by":"crossref","first-page":"1816","DOI":"10.1177\/1352458520970841","article-title":"Rising prevalence of multiple sclerosis worldwide: insights from the Atlas of MS, third edition","volume":"26","author":"Walton","year":"2020","journal-title":"Mult. Scler."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib183","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.immuni.2011.10.019","article-title":"Transcription of Il17 and Il17f is controlled by conserved noncoding sequence 2","volume":"36","author":"Wang","year":"2012","journal-title":"Immunity"},{"issue":"6","key":"10.1016\/j.bbih.2024.100928_bib184","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1016\/j.cell.2015.10.068","article-title":"CD5L\/AIM regulates lipid biosynthesis and restrains Th17 cell pathogenicity","volume":"163","author":"Wang","year":"2015","journal-title":"Cell"},{"key":"10.1016\/j.bbih.2024.100928_bib185","article-title":"IL-17 induced NOTCH1 activation in oligodendrocyte progenitor cells enhances proliferation and inflammatory gene expression","volume":"8","author":"Wang","year":"2017","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2024.100928_bib186","doi-asserted-by":"crossref","DOI":"10.1038\/s41423-023-01036-7","article-title":"Intricacies of TGF-beta signaling in Treg and Th17 cell biology","author":"Wang","year":"2023","journal-title":"Cell. Mol. Immunol."},{"issue":"9","key":"10.1016\/j.bbih.2024.100928_bib187","doi-asserted-by":"crossref","first-page":"6920","DOI":"10.1007\/s12035-024-03996-x","article-title":"Autophagy in multiple sclerosis: phagocytosis and autophagy of oligodendrocyte precursor cells","volume":"61","author":"Wang","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100928_bib188","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.immuni.2008.12.009","article-title":"Global mapping of H3K4me3 and H3K27me3 reveals specificity and plasticity in lineage fate determination of differentiating CD4+ T cells","volume":"30","author":"Wei","year":"2009","journal-title":"Immunity"},{"issue":"5","key":"10.1016\/j.bbih.2024.100928_bib189","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18051000","article-title":"Interleukin 17A promotes lymphocytes adhesion and induces CCL2 and CXCL1 release from brain endothelial cells","volume":"18","author":"Wojkowska","year":"2017","journal-title":"Int. J. Mol. Sci."},{"issue":"7446","key":"10.1016\/j.bbih.2024.100928_bib190","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1038\/nature11984","article-title":"Induction of pathogenic TH17 cells by inducible salt-sensing kinase SGK1","volume":"496","author":"Wu","year":"2013","journal-title":"Nature"},{"issue":"2","key":"10.1016\/j.bbih.2024.100928_bib191","doi-asserted-by":"crossref","first-page":"308","DOI":"10.1016\/j.immuni.2020.12.010","article-title":"The TGF-beta superfamily cytokine Activin-A is induced during autoimmune neuroinflammation and drives pathogenic Th17 cell differentiation","volume":"54","author":"Wu","year":"2021","journal-title":"Immunity"},{"issue":"25","key":"10.1016\/j.bbih.2024.100928_bib192","doi-asserted-by":"crossref","first-page":"4725","DOI":"10.1523\/JNEUROSCI.2312-22.2023","article-title":"Elevated galectin-3 is associated with aging, multiple sclerosis, and oxidized phosphatidylcholine-induced neurodegeneration","volume":"43","author":"Xue","year":"2023","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.bbih.2024.100928_bib193","doi-asserted-by":"crossref","first-page":"5377","DOI":"10.4049\/jimmunol.177.8.5377","article-title":"Two-sided roles of IL-27: induction of Th1 differentiation on naive CD4+ T cells versus suppression of proinflammatory cytokine production including IL-23-induced IL-17 on activated CD4+ T cells partially through STAT3-dependent mechanism","volume":"177","author":"Yoshimura","year":"2006","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.bbih.2024.100928_bib194","doi-asserted-by":"crossref","first-page":"1297","DOI":"10.1038\/ni.1663","article-title":"Interactions among the transcription factors Runx1, RORgammat and Foxp3 regulate the differentiation of interleukin 17-producing T cells","volume":"9","author":"Zhang","year":"2008","journal-title":"Nat. Immunol."},{"issue":"11","key":"10.1016\/j.bbih.2024.100928_bib195","doi-asserted-by":"crossref","first-page":"5139","DOI":"10.4049\/jimmunol.1401680","article-title":"IL-11 induces Th17 cell responses in patients with early relapsing-remitting multiple sclerosis","volume":"194","author":"Zhang","year":"2015","journal-title":"J. Immunol."},{"issue":"11","key":"10.1016\/j.bbih.2024.100928_bib197","doi-asserted-by":"crossref","first-page":"2079","DOI":"10.1002\/glia.24239","article-title":"The LncRNA AK018453 regulates TRAP1\/Smad signaling in IL-17-activated astrocytes: a potential role in EAE pathogenesis","volume":"70","author":"Zhang","year":"2022","journal-title":"Glia"},{"key":"10.1016\/j.bbih.2024.100928_bib198","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.molimm.2016.12.020","article-title":"IL-22 promotes Fas expression in oligodendrocytes and inhibits FOXP3 expression in T cells by activating the NF-\u03baB pathway in multiple sclerosis","volume":"82","author":"Zhen","year":"2017","journal-title":"Mol. Immunol."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624002060?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624002060?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T12:25:23Z","timestamp":1737721523000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354624002060"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":190,"alternative-id":["S2666354624002060"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100928","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Interaction between Th17 and central nervous system in multiple sclerosis","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100928","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2024 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100928"}}