{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T05:46:07Z","timestamp":1789883167377,"version":"4.0.1"},"reference-count":34,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbih.2024.100931","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T08:31:09Z","timestamp":1736065869000},"page":"100931","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0397-7904","authenticated-orcid":false,"given":"Ganesh","family":"Bushi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashok Kumar","family":"Balaraman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Gaidhane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suhas","family":"Ballal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjay","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahakshit","family":"Bhat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shilpa","family":"Sharma","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M Ravi","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aashna","family":"Sinha","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mahalaqua Nazli","family":"Khatib","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nishant","family":"Rai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sanjit","family":"Sah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ambanna","family":"Yappalparvi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2117-1856","authenticated-orcid":false,"given":"Shailesh Kumar","family":"Samal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Doddolla","family":"Lingamaiah","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Muhammed","family":"Shabil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"11","key":"10.1016\/j.bbih.2024.100931_bib1","first-page":"38","article-title":"[The clinical and serological manifestations of Lyme disease in Russia]","volume":"67","author":"Anan'eva","year":"1995","journal-title":"Ter. Arkh."},{"issue":"6","key":"10.1016\/j.bbih.2024.100931_bib2","doi-asserted-by":"crossref","first-page":"1340","DOI":"10.1093\/ije\/dyi129","article-title":"Post-Lyme borreliosis syndrome: a meta-analysis of reported symptoms","volume":"34","author":"Cairns","year":"2005","journal-title":"Int. J. Epidemiol."},{"issue":"1\u20132","key":"10.1016\/j.bbih.2024.100931_bib3","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1007\/BF03040423","article-title":"Clinical and epidemiological features of Lyme borreliosis in Bulgaria","volume":"116","author":"Christova","year":"2004","journal-title":"Wien Klin. Wochenschr."},{"issue":"4","key":"10.1016\/j.bbih.2024.100931_bib4","doi-asserted-by":"crossref","first-page":"e252","DOI":"10.1016\/j.ijid.2011.12.004","article-title":"Ultrasonographic evaluation of knee joints in patients with Lyme disease","volume":"16","author":"Czupryna","year":"2012","journal-title":"Int. J. Infect. Dis."},{"key":"10.1016\/j.bbih.2024.100931_bib5","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1007\/s100960000391","article-title":"Full spectrum of clinical, serological, and epidemiological features of complicated forms of Lyme borreliosis in the Paris, France, area","volume":"19","author":"Dh\u00f4te","year":"2000","journal-title":"Eur. J. Clin. Microbiol. Infect. Dis."},{"issue":"1","key":"10.1016\/j.bbih.2024.100931_bib6","first-page":"44","article-title":"Steps in undertaking meta-analysis and addressing heterogeneity in meta-analysis","volume":"1","author":"Gandhi","year":"2023","journal-title":"The Evidence"},{"issue":"7","key":"10.1016\/j.bbih.2024.100931_bib7","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.arcped.2021.08.001","article-title":"Lyme neuroborreliosis in pediatrics: a retrospective, descriptive study in southwest France","volume":"28","author":"Garrabe","year":"2021","journal-title":"Arch. Pediatr."},{"issue":"1","key":"10.1016\/j.bbih.2024.100931_bib8","doi-asserted-by":"crossref","first-page":"756","DOI":"10.1186\/s12879-022-07686-8","article-title":"Non-specific symptoms and post-treatment Lyme disease syndrome in patients with Lyme borreliosis: a prospective cohort study in Belgium (2016-2020)","volume":"22","author":"Geebelen","year":"2022","journal-title":"BMC Infect. Dis."},{"issue":"9","key":"10.1016\/j.bbih.2024.100931_bib9","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1093\/cid\/ciu106","article-title":"Lyme disease: neurology, neurobiology, and behavior","volume":"58","author":"Halperin","year":"2014","journal-title":"Clin. Infect. Dis."},{"issue":"7","key":"10.1016\/j.bbih.2024.100931_bib10","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2015-010247","article-title":"Plea for routinely presenting prediction intervals in meta-analysis","volume":"6","author":"IntHout","year":"2016","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.bbih.2024.100931_bib11","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1097\/INF.0000000000002493","article-title":"Comparison of neuroborreliosis between children and adults","volume":"39","author":"Krawczuk","year":"2020","journal-title":"Pediatr. Infect. Dis. J."},{"issue":"1","key":"10.1016\/j.bbih.2024.100931_bib12","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1002\/jrsm.1316","article-title":"A comparison of heterogeneity variance estimators in simulated random\u2010effects meta\u2010analyses","volume":"10","author":"Langan","year":"2019","journal-title":"Res. Synth. Methods"},{"key":"10.1016\/j.bbih.2024.100931_bib13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/1471-2288-14-45","article-title":"Newcastle-Ottawa Scale: comparing reviewers' to authors' assessments","volume":"14","author":"Lo","year":"2014","journal-title":"BMC Med. Res. Methodol."},{"issue":"21","key":"10.1016\/j.bbih.2024.100931_bib14","doi-asserted-by":"crossref","first-page":"1438","DOI":"10.1056\/NEJM199011223232102","article-title":"Chronic neurologic manifestations of Lyme disease","volume":"323","author":"Logigian","year":"1990","journal-title":"N. Engl. J. Med."},{"issue":"12","key":"10.1016\/j.bbih.2024.100931_bib15","doi-asserted-by":"crossref","first-page":"1350","DOI":"10.1136\/jnnp.2004.060731","article-title":"Clinical features of double infection with tick-borne encephalitis and Lyme borreliosis transmitted by tick bite","volume":"77","author":"Logina","year":"2006","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"issue":"10","key":"10.1016\/j.bbih.2024.100931_bib16","first-page":"51","article-title":"Lessons learned from a Rhode Island academic out-patient lyme and tick-borne disease clinic","volume":"103","author":"McCarthy","year":"2013","journal-title":"R. I. Med. J."},{"issue":"1","key":"10.1016\/j.bbih.2024.100931_bib17","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cll.2010.01.003","volume":"30","author":"Murray","year":"2010","journal-title":"Clin. Lab. Med."},{"issue":"1","key":"10.1016\/j.bbih.2024.100931_bib18","doi-asserted-by":"crossref","first-page":"33","DOI":"10.5604\/12321966.1229002","article-title":"Estimation of cognitive and affective disorders occurrence in patients with Lyme borreliosis","volume":"24","author":"Oczko-Grzesik","year":"2017","journal-title":"Ann. Agric. Environ. Med."},{"key":"10.1016\/j.bbih.2024.100931_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.ijsu.2021.105906","article-title":"The PRISMA 2020 statement: an updated guideline for reporting systematic reviews","volume":"88","author":"Page","year":"2021","journal-title":"Int. J. Surg."},{"issue":"4","key":"10.1016\/j.bbih.2024.100931_bib20","first-page":"1040","article-title":"Neurologic complications of lyme disease","volume":"27","author":"Roos","year":"2021","journal-title":"Continuum"},{"issue":"5","key":"10.1016\/j.bbih.2024.100931_bib21","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1001\/jama.283.5.609","article-title":"Long-term outcomes of persons with Lyme disease","volume":"283","author":"Seltzer","year":"2000","journal-title":"JAMA"},{"issue":"8","key":"10.1016\/j.bbih.2024.100931_bib22","doi-asserted-by":"crossref","first-page":"560","DOI":"10.7326\/0003-4819-121-8-199410150-00002","article-title":"The long-term clinical outcomes of Lyme disease. A population-based retrospective cohort study","volume":"121","author":"Shadick","year":"1994","journal-title":"Ann. Intern. Med."},{"issue":"12","key":"10.1016\/j.bbih.2024.100931_bib23","doi-asserted-by":"crossref","first-page":"919","DOI":"10.7326\/0003-4819-131-12-199912210-00003","article-title":"Musculoskeletal and neurologic outcomes in patients with previously treated Lyme disease","volume":"131","author":"Shadick","year":"1999","journal-title":"Ann. Intern. Med."},{"issue":"12","key":"10.1016\/j.bbih.2024.100931_bib24","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1542\/pir.35.12.500","article-title":"Borrelia burgdorferi (Lyme disease)","volume":"35","author":"Shapiro","year":"2014","journal-title":"Pediatr. Rev."},{"key":"10.1016\/j.bbih.2024.100931_bib25","series-title":"Lyme Disease. StatPearls","author":"Skar","year":"2024"},{"issue":"6","key":"10.1016\/j.bbih.2024.100931_bib26","doi-asserted-by":"crossref","first-page":"421","DOI":"10.7326\/0003-4819-136-6-200203190-00005","article-title":"Clinical characteristics and treatment outcome of early Lyme disease in patients with microbiologically confirmed erythema migrans","volume":"136","author":"Smith","year":"2002","journal-title":"Ann. Intern. Med."},{"issue":"2","key":"10.1016\/j.bbih.2024.100931_bib27","doi-asserted-by":"crossref","first-page":"91","DOI":"10.5435\/00124635-201102000-00004","article-title":"Lyme disease and the orthopaedic implications of lyme arthritis","volume":"19","author":"Smith","year":"2011","journal-title":"J. Am. Acad. Orthop. Surg."},{"issue":"8","key":"10.1016\/j.bbih.2024.100931_bib28","article-title":"Lyme disease and post-treatment lyme disease syndrome: current and developing treatment options","volume":"15","author":"Talbot","year":"2023","journal-title":"Cureus"},{"issue":"9","key":"10.1016\/j.bbih.2024.100931_bib29","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0185723","article-title":"IgE reactivity to \u03b1-Gal in relation to Lyme borreliosis","volume":"12","author":"Tjernberg","year":"2017","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbih.2024.100931_bib30","doi-asserted-by":"crossref","first-page":"e93","DOI":"10.1542\/peds.112.2.e93","article-title":"Long-term neuropsychologic and health outcomes of children with facial nerve palsy attributable to Lyme disease","volume":"112","author":"V\u00e1zquez","year":"2003","journal-title":"Pediatrics"},{"issue":"11","key":"10.1016\/j.bbih.2024.100931_bib31","first-page":"2249","article-title":"Outcomes of children treated for Lyme disease","volume":"25","author":"Wang","year":"1998","journal-title":"J. Rheumatol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100931_bib32","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1002\/ijgo.14672","article-title":"Association between maternal e-cigarette use during pregnancy and low gestational weight gain","volume":"162","author":"Wen","year":"2023","journal-title":"Int. J. Gynaecol. Obstet."},{"issue":"1","key":"10.1016\/j.bbih.2024.100931_bib33","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.51418","article-title":"Tick-borne disease infections and chronic musculoskeletal pain","volume":"7","author":"Zychowski","year":"2024","journal-title":"JAMA Netw. Open"},{"issue":"1","key":"10.1016\/j.bbih.2024.100931_bib34","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.51418","article-title":"Tick-borne disease infections and chronic musculoskeletal pain","volume":"7","author":"Zychowski","year":"2024","journal-title":"JAMA Netw. Open"}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624002096?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624002096?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,1,24]],"date-time":"2025-01-24T17:24:47Z","timestamp":1737739487000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354624002096"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":34,"alternative-id":["S2666354624002096"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100931","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Lyme disease associated neurological and musculoskeletal symptoms: A systematic review and meta-analysis","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100931","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100931"}}