{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,4]],"date-time":"2026-06-04T06:38:31Z","timestamp":1780555111106,"version":"3.54.1"},"reference-count":74,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,2,1]],"date-time":"2025-02-01T00:00:00Z","timestamp":1738368000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2024,12,21]],"date-time":"2024-12-21T00:00:00Z","timestamp":1734739200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["R37 AA17531"],"award-info":[{"award-number":["R37 AA17531"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000027","name":"National Institute on Alcohol Abuse and Alcoholism","doi-asserted-by":"publisher","award":["F31 AA030928"],"award-info":[{"award-number":["F31 AA030928"]}],"id":[{"id":"10.13039\/100000027","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2025,2]]},"DOI":"10.1016\/j.bbih.2024.100933","type":"journal-article","created":{"date-parts":[[2025,1,5]],"date-time":"2025-01-05T03:31:05Z","timestamp":1736047865000},"page":"100933","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":1,"special_numbering":"C","title":["Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage population density"],"prefix":"10.1016","volume":"43","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4631-8474","authenticated-orcid":false,"given":"Stephen C.","family":"Gironda","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel W.","family":"Centanni","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeffrey L.","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"4","key":"10.1016\/j.bbih.2024.100933_bib1","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1017\/S1461145710001288","article-title":"5-Hydroxytryptophan during critical postnatal period improves cognitive performances and promotes dendritic spine maturation in genetic mouse model of phenylketonuria","volume":"14","author":"Andolina","year":"2011","journal-title":"Int. J. Neuropsychopharmacol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib2","doi-asserted-by":"crossref","DOI":"10.1136\/bmjpo-2020-000939","article-title":"Bullying in children: impact on child health","volume":"5","author":"Armitage","year":"2021","journal-title":"BMJ Paediatrics Open"},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib3","doi-asserted-by":"crossref","first-page":"8749","DOI":"10.1038\/s41598-021-87899-0","article-title":"Chronic intermittent ethanol promotes ventral subiculum hyperexcitability via increases in extrinsic basolateral amygdala input and local network activity","volume":"11","author":"Bach","year":"2021","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bbih.2024.100933_bib4","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1016\/j.tins.2020.02.004","article-title":"Synthesizing views to understand sex differences in response to early life adversity","volume":"43","author":"Bath","year":"2020","journal-title":"Trends Neurosci."},{"issue":"6","key":"10.1016\/j.bbih.2024.100933_bib5","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1097\/YCO.0000000000000900","article-title":"The impact of bullying in childhood and adolescence","volume":"36","author":"Bhatia","year":"2023","journal-title":"Curr. Opin. Psychiatr."},{"key":"10.1016\/j.bbih.2024.100933_bib6","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2021.775404","article-title":"Maternal separation stress affects voluntary ethanol intake in a sex dependent manner","volume":"12","author":"Bertagna","year":"2021","journal-title":"Front. Physiol."},{"issue":"13","key":"10.1016\/j.bbih.2024.100933_bib7","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110600","article-title":"Early stress-induced impaired microglial pruning of excitatory synapses on immature CRH-expressing neurons provokes aberrant adult stress responses","volume":"38","author":"Bolton","year":"2022","journal-title":"Cell Rep."},{"issue":"6","key":"10.1016\/j.bbih.2024.100933_bib8","doi-asserted-by":"crossref","first-page":"1202","DOI":"10.1111\/acer.13075","article-title":"Adolescent social isolation as a model of heightened vulnerability to comorbid alcoholism and anxiety disorders","volume":"40","author":"Butler","year":"2016","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"14","key":"10.1016\/j.bbih.2024.100933_bib9","doi-asserted-by":"crossref","first-page":"4999","DOI":"10.3390\/ijms21144999","article-title":"Long-term impact of early-life stress on hippocampal plasticity: spotlight on astrocytes","volume":"21","author":"\u00c7al\u0131\u015fkan","year":"2020","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bbih.2024.100933_bib10","doi-asserted-by":"crossref","first-page":"468","DOI":"10.3390\/jcm9020468","article-title":"Microglial function in the effects of early-life stress on brain and behavioral development","volume":"9","author":"Catale","year":"2020","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbih.2024.100933_bib11","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2020.100249","article-title":"Exposure to different early-life stress experiences results in differentially altered DNA methylation in the brain and immune system","volume":"13","author":"Catale","year":"2020","journal-title":"Neurobiology of Stress"},{"issue":"6","key":"10.1016\/j.bbih.2024.100933_bib12","doi-asserted-by":"crossref","first-page":"3913","DOI":"10.1007\/s12035-022-02830-6","article-title":"Early life social stress causes sex- and region-dependent dopaminergic changes that are prevented by minocycline","volume":"59","author":"Catale","year":"2022","journal-title":"Mol. Neurobiol."},{"issue":"11","key":"10.1016\/j.bbih.2024.100933_bib13","doi-asserted-by":"crossref","first-page":"1109","DOI":"10.1038\/s41592-019-0615-4","article-title":"Light-sheet microscopy of cleared tissues with isotropic, subcellular resolution","volume":"16","author":"Chakraborty","year":"2019","journal-title":"Nat. Methods"},{"issue":"Suppl. 1","key":"10.1016\/j.bbih.2024.100933_bib14","first-page":"E394","article-title":"Adolescent rearing conditions influence the relationship between initial anxiety-like behavior and ethanol drinking in male long evans rats","volume":"37","author":"Chappell","year":"2013","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"9","key":"10.1016\/j.bbih.2024.100933_bib15","doi-asserted-by":"crossref","first-page":"1579","DOI":"10.1038\/s41386-019-0326-7","article-title":"Early life alcohol exposure primes hypothalamic microglia to later-life hypersensitivity to immune stress: possible epigenetic mechanism","volume":"44","author":"Chastain","year":"2019","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib16","doi-asserted-by":"crossref","first-page":"99","DOI":"10.1038\/npp.2016.198","article-title":"Psychoneuroimmunology of early-life stress: the hidden wounds of childhood trauma?","volume":"42","author":"Danese","year":"2017","journal-title":"Neuropsychopharmacology"},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib17","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-017-01747-8","article-title":"Characterizing microglia activation: a spatial statistics approach to maximize information extraction","volume":"7","author":"Davis","year":"2017","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.bbih.2024.100933_bib18","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1037\/adb0000394","article-title":"Examining the pathways between bully victimization, depression, academic achievement, and problematic drinking in adolescence","volume":"32","author":"Davis","year":"2018","journal-title":"Psychol. Addict. Behav."},{"key":"10.1016\/j.bbih.2024.100933_bib19","doi-asserted-by":"crossref","DOI":"10.1016\/j.biopha.2024.116316","article-title":"Ethanol binge drinking exposure during adolescence displays long-lasting motor dysfunction related to cerebellar neurostructural damage even after long-term withdrawal in female Wistar rats","volume":"173","author":"de Oliveira","year":"2024","journal-title":"Biomed. Pharmacother."},{"key":"10.1016\/j.bbih.2024.100933_bib20","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.neuroscience.2018.11.028","article-title":"Chronic intermittent ethanol exposure selectively increases synaptic excitability in the ventral domain of the rat Hippocampus","volume":"398","author":"Ewin","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbih.2024.100933_bib21","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1016\/j.psyneuen.2013.11.006","article-title":"Chronic exposure to exogenous glucocorticoids primes microglia to pro-inflammatory stimuli and induces NLRP3 mRNA in the hippocampus","volume":"40","author":"Frank","year":"2014","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib22","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1038\/s41398-021-01478-5","article-title":"Ibudilast, a neuroimmune modulator, reduces heavy drinking and alcohol cue-elicited neural activation: a randomized trial","volume":"11","author":"Grodin","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbih.2024.100933_bib23","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1016\/j.neuroscience.2017.12.039","article-title":"Microglial priming as trained immunity in the brain","volume":"405","author":"Haley","year":"2019","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbih.2024.100933_bib24","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12887-020-02116-7","article-title":"Validation of the AUDIT scale and factors associated with alcohol use disorder in adolescents: results of a National Lebanese Study","volume":"20","author":"Hallit","year":"2020","journal-title":"BMC Pediatr."},{"key":"10.1016\/j.bbih.2024.100933_bib25","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.744690","article-title":"Impact of early life stress on reward circuit function and regulation","volume":"12","author":"Hanson","year":"2021","journal-title":"Front. Psychiatr."},{"issue":"27","key":"10.1016\/j.bbih.2024.100933_bib26","doi-asserted-by":"crossref","first-page":"6475","DOI":"10.1523\/JNEUROSCI.0651-17.2017","article-title":"Tactile defensiveness and impaired adaptation of neuronal activity in the Fmr1 knock-out mouse model of autism","volume":"37","author":"He","year":"2017","journal-title":"J. Neurosci.: The Off. J. Soc. Neurosci."},{"key":"10.1016\/j.bbih.2024.100933_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.drugalcdep.2023.111026","article-title":"Adolescent intermittent ethanol exposure alters adult exploratory and affective behaviors, and cerebellar Grin2b expression in C57BL\/6J mice","volume":"253","author":"Healey","year":"2023","journal-title":"Drug Alcohol Depend."},{"key":"10.1016\/j.bbih.2024.100933_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuroimage.2019.116493","article-title":"Early life stress and brain function: activity and connectivity associated with processing emotion and reward","volume":"209","author":"Herzberg","year":"2020","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbih.2024.100933_bib29","doi-asserted-by":"crossref","DOI":"10.1016\/j.pbb.2022.173360","article-title":"Early life stress and substance use disorders: the critical role of adolescent substance use","volume":"215","author":"Kirsch","year":"2022","journal-title":"Pharmacol. Biochem. Behav."},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib30","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/npp.2009.110","article-title":"Neurocircuitry of addiction","volume":"35","author":"Koob","year":"2010","journal-title":"Neuropsychopharmacology"},{"issue":"3","key":"10.1016\/j.bbih.2024.100933_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1590\/1516-4446-2018-0183","article-title":"From anatomy to function: the role of the somatosensory cortex in emotional regulation","volume":"41","author":"Kropf","year":"2018","journal-title":"Rev. Bras. Psiquiatr."},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib32","doi-asserted-by":"crossref","first-page":"e5","DOI":"10.4110\/in.2018.18.e5","article-title":"Tissue-specific role of CX3CR1 expressing immune cells and their relationships with human disease","volume":"18","author":"Lee","year":"2018","journal-title":"Immune Network"},{"issue":"12","key":"10.1016\/j.bbih.2024.100933_bib33","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.biopsych.2018.05.022","article-title":"From traumatic childhood to cocaine abuse: the critical function of the immune system","volume":"84","author":"Lo Iacono","year":"2018","journal-title":"Biol. Psychiatr."},{"issue":"4","key":"10.1016\/j.bbih.2024.100933_bib34","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1111\/adb.12373","article-title":"Social threat exposure in juvenile mice promotes cocaine-seeking by altering blood clotting and brain vasculature","volume":"22","author":"Lo Iacono","year":"2017","journal-title":"Addiction Biol."},{"key":"10.1016\/j.bbih.2024.100933_bib35","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.neuropharm.2015.12.011","article-title":"Regulation of nucleus accumbens transcript levels in mice by early-life social stress and cocaine","volume":"103","author":"Lo Iacono","year":"2016","journal-title":"Neuropharmacology"},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib36","doi-asserted-by":"crossref","first-page":"3561","DOI":"10.1038\/s41467-021-23674-z","article-title":"Delineation of an insula-BNST circuit engaged by struggling behavior that regulates avoidance in mice","volume":"12","author":"Luchsinger","year":"2021","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2024.100933_bib37","doi-asserted-by":"crossref","DOI":"10.1038\/srep25663","article-title":"CSF1R blockade slows the progression of amyotrophic lateral sclerosis by reducing microgliosis and invasion of macrophages into peripheral nerves","volume":"6","author":"Mart\u00ednez-Muriana","year":"2016","journal-title":"Sci. Rep."},{"issue":"10","key":"10.1016\/j.bbih.2024.100933_bib38","doi-asserted-by":"crossref","first-page":"1908","DOI":"10.1111\/acer.14694","article-title":"Primed for addiction: a critical review of the role of microglia in the neurodevelopmental consequences of adolescent alcohol drinking","volume":"45","author":"Melbourne","year":"2021","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"16","key":"10.1016\/j.bbih.2024.100933_bib39","doi-asserted-by":"crossref","first-page":"8678","DOI":"10.3390\/ijerph18168678","article-title":"Mechanisms of ethanol-induced cerebellar ataxia: underpinnings of neuronal death in the cerebellum","volume":"18","author":"Mitoma","year":"2021","journal-title":"Int. J. Environ. Res. Publ. Health"},{"issue":"3","key":"10.1016\/j.bbih.2024.100933_bib40","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1111\/adb.12101","article-title":"The cerebellum and addiction: insights gained from neuroimaging research","volume":"19","author":"Moulton","year":"2014","journal-title":"Addiction Biol."},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib41","doi-asserted-by":"crossref","first-page":"7236","DOI":"10.1038\/s41598-020-64075-4","article-title":"Long-term aberrations to cerebellar endocannabinoids induced by early-life stress","volume":"10","author":"Moussa-Tooks","year":"2020","journal-title":"Sci. Rep."},{"issue":"6","key":"10.1016\/j.bbih.2024.100933_bib42","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0124-18.2018","article-title":"High-fidelity imaging in brain-wide structural studies using light-sheet microscopy","volume":"5","author":"M\u00fcllenbroich","year":"2018","journal-title":"eNeuro"},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib43","doi-asserted-by":"crossref","first-page":"1679","DOI":"10.1096\/fj.201900567RR","article-title":"Pharmacological inhibition of CSF1R by GW2580 reduces microglial proliferation and is protective against neuroinflammation and dopaminergic neurodegeneration","volume":"34","author":"Neal","year":"2020","journal-title":"FASEB J.: Off. Publ. Fed. Am. Soc. Exp. Biol."},{"issue":"4","key":"10.1016\/j.bbih.2024.100933_bib44","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.it.2019.02.001","article-title":"Priming microglia for innate immune memory in the brain","volume":"40","author":"Neher","year":"2019","journal-title":"Trends Immunol."},{"issue":"4","key":"10.1016\/j.bbih.2024.100933_bib45","doi-asserted-by":"crossref","first-page":"933","DOI":"10.31083\/j.jin2004094","article-title":"Repetitive binge-like consumption based on the Drinking-in-the-Dark model alters the microglial population in the mouse hippocampus","volume":"20","author":"Nelson","year":"2021","journal-title":"J. Integr. Neurosci."},{"key":"10.1016\/j.bbih.2024.100933_bib46","doi-asserted-by":"crossref","DOI":"10.1016\/j.ynstr.2020.100269","article-title":"A novel mouse model for vulnerability to alcohol dependence induced by early-life adversity","volume":"13","author":"Okhuarobo","year":"2020","journal-title":"Neurobiology of Stress"},{"issue":"6048","key":"10.1016\/j.bbih.2024.100933_bib47","doi-asserted-by":"crossref","first-page":"1456","DOI":"10.1126\/science.1202529","article-title":"Synaptic pruning by microglia is necessary for normal brain development","volume":"333","author":"Paolicelli","year":"2011","journal-title":"Science (New York, N.Y.)"},{"key":"10.1016\/j.bbih.2024.100933_bib48","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3389\/fnsyn.2017.00009","article-title":"Function and dysfunction of microglia during brain development: consequences for synapses and neural circuits","volume":"9","author":"Paolicelli","year":"2017","journal-title":"Front. Synaptic Neurosci."},{"issue":"21","key":"10.1016\/j.bbih.2024.100933_bib49","doi-asserted-by":"crossref","first-page":"3458","DOI":"10.1016\/j.neuron.2022.10.020","article-title":"Microglia states and nomenclature: a field at its crossroads","volume":"110","author":"Paolicelli","year":"2022","journal-title":"Neuron"},{"key":"10.1016\/j.bbih.2024.100933_bib50","article-title":"Early childhood stress is associated with blunted development of ventral tegmental area functional connectivity","volume":"47","author":"Park","year":"2021","journal-title":"Dev. Cognit. Neurosci."},{"key":"10.1016\/j.bbih.2024.100933_bib51","article-title":"Protection of tissue physicochemical properties using polyfunctional crosslinkers","author":"Park","year":"2018","journal-title":"Nat. Biotechnol."},{"key":"10.1016\/j.bbih.2024.100933_bib52","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1038\/s41398-022-02265-6","article-title":"Early-life stress lastingly impacts microglial transcriptome and function under basal and immune-challenged conditions","volume":"12","author":"Reemst","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib53","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.physbeh.2004.10.007","article-title":"Evaluation of a simple model of ethanol drinking to intoxication in C57BL\/6J mice","volume":"84","author":"Rhodes","year":"2005","journal-title":"Physiol. Behav."},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib54","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1111\/adb.12184","article-title":"Social defeat in adolescent mice increases vulnerability to alcohol consumption","volume":"21","author":"Rodriguez\u2010Arias","year":"2016","journal-title":"Addiction Biol."},{"issue":"5","key":"10.1016\/j.bbih.2024.100933_bib56","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1016\/j.amepre.2015.05.031","article-title":"2010 National and State costs of excessive alcohol consumption","volume":"49","author":"Sacks","year":"2015","journal-title":"Am. J. Prev. Med."},{"issue":"6","key":"10.1016\/j.bbih.2024.100933_bib57","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1007\/BF02463354","article-title":"Distribution of microglia and astrocytes in different regions of the normal adult rat brain","volume":"29","author":"Savchenko","year":"1997","journal-title":"Neurophysiology"},{"issue":"3","key":"10.1016\/j.bbih.2024.100933_bib58","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1523\/JNEUROSCI.2516-12.2013","article-title":"Adolescent morphine exposure affects long-term microglial function and later-life relapse liability in a model of addiction","volume":"33","author":"Schwarz","year":"2013","journal-title":"J. Neurosci."},{"issue":"8","key":"10.1016\/j.bbih.2024.100933_bib59","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1038\/mp.2016.25","article-title":"Alcohol affects brain functional connectivity and its coupling with behavior: greater effects in male heavy drinkers","volume":"22","author":"Shokri-Kojori","year":"2017","journal-title":"Mol. Psychiatr."},{"issue":"5","key":"10.1016\/j.bbih.2024.100933_bib60","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1007\/s12035-018-1325-0","article-title":"Cocaine mediated neuroinflammation: role of dysregulated autophagy in pericytes","volume":"56","author":"Sil","year":"2019","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbih.2024.100933_bib61","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1016\/j.neuropharm.2015.05.025","article-title":"Adolescent social isolation increases anxiety-like behavior and ethanol intake and impairs fear extinction in adulthood: possible role of disrupted noradrenergic signaling","volume":"97","author":"Skelly","year":"2015","journal-title":"Neuropharmacology"},{"issue":"7","key":"10.1016\/j.bbih.2024.100933_bib62","doi-asserted-by":"crossref","first-page":"1468","DOI":"10.1111\/acer.14640","article-title":"Adverse social experiences in adolescent rats result in persistent sex-dependent effects on alcohol-seeking behavior","volume":"45","author":"Surakka","year":"2021","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"5","key":"10.1016\/j.bbih.2024.100933_bib63","doi-asserted-by":"crossref","first-page":"2348","DOI":"10.1038\/s44319-024-00130-9","article-title":"Lifelong absence of microglia alters hippocampal glutamatergic networks but not synapse and spine density","volume":"25","author":"Surala","year":"2024","journal-title":"EMBO Rep."},{"issue":"4","key":"10.1016\/j.bbih.2024.100933_bib64","doi-asserted-by":"crossref","first-page":"512","DOI":"10.1016\/j.amepre.2022.10.017","article-title":"Associations of adverse childhood experiences with pregnancy and infant health","volume":"64","author":"Swedo","year":"2023","journal-title":"Am. J. Prev. Med."},{"key":"10.1016\/j.bbih.2024.100933_bib65","doi-asserted-by":"crossref","first-page":"15","DOI":"10.3389\/fnmol.2015.00015","article-title":"Alteration of somatosensory response in adulthood by early life stress","volume":"8","author":"Takatsuru","year":"2015","journal-title":"Front. Mol. Neurosci."},{"issue":"2","key":"10.1016\/j.bbih.2024.100933_bib66","doi-asserted-by":"crossref","first-page":"351","DOI":"10.1038\/s41380-019-0609-8","article-title":"Microglial regional heterogeneity and its role in the brain","volume":"25","author":"Tan","year":"2020","journal-title":"Mol. Psychiatr."},{"issue":"3","key":"10.1016\/j.bbih.2024.100933_bib67","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.alcohol.2013.08.005","article-title":"\u201cDrinking in the Dark\u201d (DID) procedures: a model of binge-like ethanol drinking in non-dependent mice","volume":"48","author":"Thiele","year":"2014","journal-title":"Alcohol (Fayetteville, N.Y.)"},{"issue":"June 23","key":"10.1016\/j.bbih.2024.100933_bib68","article-title":"Linking external stimuli with internal drives: a role for the ventral Hippocampus","volume":"76","author":"Turner","year":"2022","journal-title":"Curr. Opin. Neurobiol."},{"issue":"7","key":"10.1016\/j.bbih.2024.100933_bib69","doi-asserted-by":"crossref","first-page":"2081","DOI":"10.3390\/jcm9072081","article-title":"The inflammatory response to alcohol consumption and its role in the pathology of alcohol hangover","volume":"9","author":"van de Loo","year":"2020","journal-title":"J. Clin. Med."},{"issue":"1","key":"10.1016\/j.bbih.2024.100933_bib70","doi-asserted-by":"crossref","first-page":"244","DOI":"10.1038\/s41398-022-02001-0","article-title":"The effects of early life adversity on children's mental health and cognitive functioning","volume":"12","author":"Wade","year":"2022","journal-title":"Transl. Psychiatry"},{"issue":"12","key":"10.1016\/j.bbih.2024.100933_bib71","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/j.biopsych.2020.05.011","article-title":"Microglia control escalation of drinking in alcohol-dependent mice: genomic and synaptic drivers","volume":"88","author":"Warden","year":"2020","journal-title":"Biol. Psychiatr."},{"issue":"2","key":"10.1016\/j.bbih.2024.100933_bib72","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1016\/j.neuron.2012.11.022","article-title":"Social deprivation enhances VTA synaptic plasticity and drug-induced contextual learning","volume":"77","author":"Whitaker","year":"2013","journal-title":"Neuron"},{"key":"10.1016\/j.bbih.2024.100933_bib73","doi-asserted-by":"crossref","first-page":"288","DOI":"10.1016\/j.jpsychires.2023.05.064","article-title":"Neural reactivity to threat impacts the association between bullying victimization and suicide risk in youth","volume":"163","author":"Yang","year":"2023","journal-title":"J. Psychiatr. Res."},{"issue":"6","key":"10.1016\/j.bbih.2024.100933_bib74","doi-asserted-by":"crossref","first-page":"1711","DOI":"10.1007\/s00213-018-4875-y","article-title":"Ethanol actions on the ventral tegmental area: novel potential targets on reward pathway neurons","volume":"235","author":"You","year":"2018","journal-title":"Psychopharmacology"},{"issue":"3","key":"10.1016\/j.bbih.2024.100933_bib75","doi-asserted-by":"crossref","first-page":"181","DOI":"10.1016\/j.tins.2023.12.003","article-title":"Tuning neural circuits and behaviors by microglia in the adult brain","volume":"47","author":"Zhao","year":"2024","journal-title":"Trends Neurosci."}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624002114?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354624002114?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:10:34Z","timestamp":1778919034000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354624002114"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,2]]},"references-count":74,"alternative-id":["S2666354624002114"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100933","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2024.07.27.605403","asserted-by":"object"}]},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2025,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Early life psychosocial stress increases binge-like ethanol consumption and CSF1R inhibition prevents stress-induced alterations in microglia and brain macrophage population density","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2024.100933","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100933"}}