{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,18]],"date-time":"2026-09-18T13:08:54Z","timestamp":1789736934575,"version":"4.0.1"},"reference-count":131,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,3,1]],"date-time":"2025-03-01T00:00:00Z","timestamp":1740787200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,2,23]],"date-time":"2025-02-23T00:00:00Z","timestamp":1740268800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100005946","name":"Jackson Laboratory","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100005946","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008476","name":"University of California, Irvine","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008476","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007880","name":"Johns Hopkins University","doi-asserted-by":"publisher","award":["101045"],"award-info":[{"award-number":["101045"]}],"id":[{"id":"10.13039\/100007880","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100006928","name":"Ohio State University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100006928","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG028271"],"award-info":[{"award-number":["R01AG028271"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R03AG067061"],"award-info":[{"award-number":["R03AG067061"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2025,3]]},"DOI":"10.1016\/j.bbih.2025.100969","type":"journal-article","created":{"date-parts":[[2025,2,25]],"date-time":"2025-02-25T04:35:52Z","timestamp":1740458152000},"page":"100969","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":4,"special_numbering":"C","title":["Ligature-induced periodontitis in a transgenic mouse model of Alzheimer's disease dysregulates neuroinflammation, exacerbates cognitive impairment, and accelerates amyloid pathology"],"prefix":"10.1016","volume":"44","author":[{"given":"Daniela M.","family":"Jimenez-Harrison","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael J.","family":"Butler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haanya","family":"Ijaz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rami","family":"Alsabbagh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Menaz N.","family":"Bettes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James W.","family":"DeMarsh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sabrina E.","family":"Mackey-Alfonso","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie M.","family":"Muscat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bryan D.","family":"Alvarez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jade A.","family":"Blackwell","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ashton","family":"Taylor","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeferson","family":"Jantsch","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A.","family":"Sanchez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sarah B.","family":"Peters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7224-4109","authenticated-orcid":false,"given":"Ruth M.","family":"Barrientos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2025.100969_bib1","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/j.jim.2013.05.002","article-title":"Optimization of the ligature-induced periodontitis model in mice","volume":"394","author":"Abe","year":"2013","journal-title":"J. Immunol. Methods"},{"key":"10.1016\/j.bbih.2025.100969_bib2","doi-asserted-by":"crossref","first-page":"1375","DOI":"10.1172\/JCI10530","article-title":"IL-4 abrogates osteoclastogenesis through STAT6-dependent inhibition of NF-kappaB","volume":"107","author":"Abu-Amer","year":"2001","journal-title":"J. Clin. Investig."},{"key":"10.1016\/j.bbih.2025.100969_bib3","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3233\/JAD-2008-14305","article-title":"Reduced expression of the inhibitory synapse Scaffolding protein gephyrin in alzheimer's disease","volume":"14","author":"Agarwal","year":"2008","journal-title":"J. Alzheim. Dis."},{"key":"10.1016\/j.bbih.2025.100969_bib4","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1037\/a0018320","article-title":"Lesions of the rat perirhinal cortex spare the acquisition of a complex configural visual discrimination yet impair object recognition","volume":"124","author":"Aggleton","year":"2010","journal-title":"Behav. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib5","doi-asserted-by":"crossref","first-page":"875091","DOI":"10.3389\/fmicb.2022.875091","article-title":"Periodontitis induced by orthodontic wire ligature drives oral microflora dysbiosis and aggravates alveolar bone loss in an improved murine model","volume":"13","author":"Ai","year":"2022","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbih.2025.100969_bib6","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S0197-4580(00)00124-X","article-title":"Inflammation and Alzheimer's disease","volume":"21","author":"Akiyama","year":"2000","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2025.100969_bib7","doi-asserted-by":"crossref","first-page":"3708","DOI":"10.1002\/alz.13809","article-title":"2024 Alzheimer's disease facts and figures","volume":"20","author":"Alzheimer's Association","year":"2024","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2025.100969_bib8","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1161\/01.ATV.0000078603.90302.4A","article-title":"Periodontal disease is associated with brachial artery endothelial dysfunction and systemic inflammation","volume":"23","author":"Amar","year":"2003","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbih.2025.100969_bib9","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.neurobiolaging.2018.06.002","article-title":"Doxycycline counteracts neuroinflammation restoring memory in Alzheimer's disease mouse models","volume":"70","author":"Balducci","year":"2018","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2025.100969_bib10","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1038\/s41368-022-00183-3","article-title":"Periodontitis may induce gut microbiota dysbiosis via salivary microbiota","volume":"14","author":"Bao","year":"2022","journal-title":"Int. J. Oral Sci."},{"key":"10.1016\/j.bbih.2025.100969_bib11","doi-asserted-by":"crossref","first-page":"723","DOI":"10.1016\/j.neurobiolaging.2005.03.010","article-title":"Peripheral infection and aging interact to impair hippocampal memory consolidation","volume":"27","author":"Barrientos","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2025.100969_bib12","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.neuroscience.2015.03.007","article-title":"Neuroinflammation in the normal aging hippocampus","volume":"309","author":"Barrientos","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbih.2025.100969_bib13","doi-asserted-by":"crossref","DOI":"10.1111\/acel.12873","article-title":"Temporal and regional progression of Alzheimer's disease-like pathology in 3xTg-AD mice","volume":"18","author":"Belfiore","year":"2019","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbih.2025.100969_bib14","doi-asserted-by":"crossref","first-page":"2443","DOI":"10.1073\/pnas.041493198","article-title":"IL-4 inhibits osteoclast formation through a direct action on osteoclast precursors via peroxisome proliferator-activated receptor gamma 1","volume":"98","author":"Bendixen","year":"2001","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbih.2025.100969_bib15","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/B978-0-12-385883-2.00008-4","article-title":"The genetics of Alzheimer's disease","volume":"107","author":"Bertram","year":"2012","journal-title":"Prog Mol Biol Transl Sci"},{"key":"10.1016\/j.bbih.2025.100969_bib16","doi-asserted-by":"crossref","first-page":"157","DOI":"10.3233\/JAD-200064","article-title":"Clinical and bacterial markers of periodontitis and their association with incident all-cause and alzheimer's disease dementia in a large national survey","volume":"75","author":"Beydoun","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2025.100969_bib17","doi-asserted-by":"crossref","first-page":"1183415","DOI":"10.3389\/fmicb.2023.1183415","article-title":"Porphyromonas gingivalis induces an inflammatory response via the cGAS-STING signaling pathway in a periodontitis mouse model","volume":"14","author":"Bi","year":"2023","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbih.2025.100969_bib18","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1474-9728.2004.00101.x","article-title":"How chronic inflammation can affect the brain and support the development of Alzheimer's disease in old age: the role of microglia and astrocytes","volume":"3","author":"Blasko","year":"2004","journal-title":"Aging Cell"},{"key":"10.1016\/j.bbih.2025.100969_bib19","doi-asserted-by":"crossref","first-page":"14515","DOI":"10.1073\/pnas.0406344101","article-title":"Spatial memory, recognition memory, and the hippocampus","volume":"101","author":"Broadbent","year":"2004","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbih.2025.100969_bib20","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.bbi.2020.06.010","article-title":"Fatty food, fatty acids, and microglial priming in the adult and aged hippocampus and amygdala","volume":"89","author":"Butler","year":"2020","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2025.100969_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2019.00008","article-title":"A specific role of hippocampal NMDA receptors and arc protein in rapid encoding of novel environmental representations and a more general long-term consolidation function","volume":"13","author":"Bye","year":"2019","journal-title":"Frontiers in Behavioral Neuroscience"},{"issue":"1","key":"10.1016\/j.bbih.2025.100969_bib22","first-page":"S1","article-title":"A new classification scheme for periodontal and peri-implant diseases and conditions - introduction and key changes from the 1999 classification","volume":"89","author":"Caton","year":"2018","journal-title":"J. Periodontol."},{"issue":"64","key":"10.1016\/j.bbih.2025.100969_bib23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12002","article-title":"Inflammatory and immune pathways in the pathogenesis of periodontal disease","volume":"2000","author":"Cekici","year":"2014","journal-title":"Periodontol"},{"key":"10.1016\/j.bbih.2025.100969_bib24","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1186\/s13024-019-0307-7","article-title":"Reduced presynaptic vesicle stores mediate cellular and network plasticity defects in an early-stage mouse model of Alzheimer's disease","volume":"14","author":"Chakroborty","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbih.2025.100969_bib25","doi-asserted-by":"crossref","DOI":"10.1002\/jbm4.10474","article-title":"Guidelines for micro-computed tomography analysis of rodent dentoalveolar tissues","volume":"5","author":"Chavez","year":"2021","journal-title":"JBMR Plus"},{"key":"10.1016\/j.bbih.2025.100969_bib26","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s13195-017-0282-6","article-title":"Association between chronic periodontitis and the risk of Alzheimer's disease: a retrospective, population-based, matched-cohort study","volume":"9","author":"Chen","year":"2017","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bbih.2025.100969_bib27","doi-asserted-by":"crossref","first-page":"755925","DOI":"10.3389\/fcimb.2021.755925","article-title":"Porphyromonas gingivalis-induced cognitive impairment is associated with gut dysbiosis, neuroinflammation, and glymphatic dysfunction","volume":"11","author":"Chi","year":"2021","journal-title":"Front. Cell. Infect. Microbiol."},{"key":"10.1016\/j.bbih.2025.100969_bib28","doi-asserted-by":"crossref","first-page":"527543","DOI":"10.3389\/fnmol.2020.527543","article-title":"Object recognition memory: distinct yet complementary roles of the mouse CA1 and perirhinal cortex","volume":"13","author":"Cinalli","year":"2020","journal-title":"Front. Mol. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib29","doi-asserted-by":"crossref","first-page":"9275","DOI":"10.1523\/JNEUROSCI.2614-05.2005","article-title":"Central and systemic endotoxin challenges exacerbate the local inflammatory response and increase neuronal death during chronic neurodegeneration","volume":"25","author":"Cunningham","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib30","doi-asserted-by":"crossref","first-page":"951","DOI":"10.3233\/JAD-210092","article-title":"Combination of plasma neurofilament light chain and mini-mental state examination score predicts progression from mild cognitive impairment to alzheimer's disease within 5 years","volume":"82","author":"Darmanthe","year":"2021","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2025.100969_bib31","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1902\/jop.2013.130225","article-title":"Evaluation of the host response in various models of induced periodontal disease in mice","volume":"85","author":"de Molon","year":"2014","journal-title":"J. Periodontol."},{"key":"10.1016\/j.bbih.2025.100969_bib32","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1007\/s00784-015-1607-0","article-title":"Long-term evaluation of oral gavage with periodontopathogens or ligature induction of experimental periodontal disease in mice","volume":"20","author":"de Molon","year":"2016","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.bbih.2025.100969_bib33","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1002\/jemt.23101","article-title":"Characterization of ligature-induced experimental periodontitis","volume":"81","author":"de Molon","year":"2018","journal-title":"Microsc. Res. Tech."},{"key":"10.1016\/j.bbih.2025.100969_bib34","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s00784-020-03489-w","article-title":"Association between periodontitis and Alzheimer's disease and its impact on the self-perceived oral health status: a case-control study","volume":"25","author":"de Oliveira Araujo","year":"2021","journal-title":"Clin Oral Investig"},{"key":"10.1016\/j.bbih.2025.100969_bib35","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1002\/ana.410270502","article-title":"Synapse loss in frontal cortex biopsies in Alzheimer's disease: correlation with cognitive severity","volume":"27","author":"DeKosky","year":"1990","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbih.2025.100969_bib36","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.1002\/hipo.22046","article-title":"Perirhinal cortex represents nonspatial, but not spatial, information in rats foraging in the presence of objects: comparison with lateral entorhinal cortex","volume":"22","author":"Deshmukh","year":"2012","journal-title":"Hippocampus"},{"key":"10.1016\/j.bbih.2025.100969_bib37","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s13024-019-0333-5","article-title":"The neuropathological diagnosis of Alzheimer's disease","volume":"14","author":"DeTure","year":"2019","journal-title":"Mol. Neurodegener."},{"key":"10.1016\/j.bbih.2025.100969_bib38","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/s41432-021-0214-y","article-title":"Does periodontal disease elevate the risk of Alzheimer's disease and mild cognitive impairment?","volume":"22","author":"Dhingra","year":"2021","journal-title":"Evid Based Dent"},{"key":"10.1016\/j.bbih.2025.100969_bib39","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.aau3333","article-title":"Porphyromonas gingivalis in Alzheimer's disease brains: evidence for disease causation and treatment with small-molecule inhibitors","volume":"5","author":"Dominy","year":"2019","journal-title":"Sci. Adv."},{"key":"10.1016\/j.bbih.2025.100969_bib40","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3233\/JAD-200982","article-title":"Inflammation in alzheimer's disease: do sex and APOE matter?","volume":"78","author":"Duarte-Guterman","year":"2020","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2025.100969_bib41","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1177\/1533317506289260","article-title":"Systemic inflammatory markers and risk of dementia","volume":"21","author":"Dziedzic","year":"2006","journal-title":"Am J Alzheimers Dis Other Demen"},{"key":"10.1016\/j.bbih.2025.100969_bib42","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1016\/j.adaj.2018.04.023","article-title":"Periodontitis in US adults: national health and nutrition examination survey 2009-2014","volume":"149","author":"Eke","year":"2018","journal-title":"J. Am. Dent. Assoc."},{"key":"10.1016\/j.bbih.2025.100969_bib43","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1096\/fj.09-139634","article-title":"RAGE-dependent signaling in microglia contributes to neuroinflammation, Abeta accumulation, and impaired learning\/memory in a mouse model of Alzheimer's disease","volume":"24","author":"Fang","year":"2010","journal-title":"FASEB J."},{"key":"10.1016\/j.bbih.2025.100969_bib44","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1038\/s41582-018-0032-9","article-title":"Sex differences in Alzheimer disease - the gateway to precision medicine","volume":"14","author":"Ferretti","year":"2018","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbih.2025.100969_bib45","doi-asserted-by":"crossref","first-page":"717","DOI":"10.1016\/j.neurobiolaging.2005.03.013","article-title":"mRNA up-regulation of MHC II and pivotal pro-inflammatory genes in normal brain aging","volume":"27","author":"Frank","year":"2006","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2025.100969_bib46","doi-asserted-by":"crossref","first-page":"2849","DOI":"10.1093\/brain\/awac083","article-title":"Microglial large extracellular vesicles propagate early synaptic dysfunction in Alzheimer's disease","volume":"145","author":"Gabrielli","year":"2022","journal-title":"Brain"},{"key":"10.1016\/j.bbih.2025.100969_bib47","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1111\/jre.13062","article-title":"The effect of Porphyromonas gingivalis on the gut microbiome of mice in relation to aging","volume":"57","author":"Giri","year":"2022","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.bbih.2025.100969_bib48","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1007\/s13311-014-0295-9","article-title":"Genetics of Alzheimer's disease","volume":"11","author":"Guerreiro","year":"2014","journal-title":"Neurotherapeutics"},{"key":"10.1016\/j.bbih.2025.100969_bib49","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1016\/j.bbi.2009.10.002","article-title":"Sustained hippocampal IL-1\u03b2 overexpression impairs contextual and spatial memory in transgenic mice","volume":"24","author":"Hein","year":"2010","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbih.2025.100969_bib50","first-page":"S11","article-title":"Diagnosis and classification of periodontal disease","volume":"54","author":"Highfield","year":"2009","journal-title":"Aust. Dent. J."},{"key":"10.1016\/j.bbih.2025.100969_bib51","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1016\/j.neuron.2010.11.030","article-title":"Tau mislocalization to dendritic spines mediates synaptic dysfunction independently of neurodegeneration","volume":"68","author":"Hoover","year":"2010","journal-title":"Neuron"},{"key":"10.1016\/j.bbih.2025.100969_bib52","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1186\/s13041-018-0406-3","article-title":"Differential modulation of NMDA and AMPA receptors by cellular prion protein and copper ions","volume":"11","author":"Huang","year":"2018","journal-title":"Mol. Brain"},{"key":"10.1016\/j.bbih.2025.100969_bib53","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1038\/s41514-017-0015-x","article-title":"Periodontitis induced by bacterial infection exacerbates features of Alzheimer's disease in transgenic mice","volume":"3","author":"Ishida","year":"2017","journal-title":"NPJ Aging Mech Dis"},{"key":"10.1016\/j.bbih.2025.100969_bib54","doi-asserted-by":"crossref","first-page":"785276","DOI":"10.3389\/fnins.2021.785276","article-title":"Systematic phenotyping and characterization of the 3xTg-AD mouse model of alzheimer's disease","volume":"15","author":"Javonillo","year":"2021","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib55","doi-asserted-by":"crossref","first-page":"1141339","DOI":"10.3389\/fncel.2023.1141339","article-title":"Porphyromonas gingivalis-induced periodontitis could contribute to cognitive impairment in Sprague-Dawley rats via the P38 MAPK signaling pathway","volume":"17","author":"Jin","year":"2023","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib56","doi-asserted-by":"crossref","first-page":"11","DOI":"10.3389\/fncel.2014.00011","article-title":"Selective increases of AMPA, NMDA, and kainate receptor subunit mRNAs in the hippocampus and orbitofrontal cortex but not in prefrontal cortex of human alcoholics","volume":"8","author":"Jin","year":"2014","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib57","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/S0197-4580(98)00007-4","article-title":"Volumes of the entorhinal and perirhinal cortices in Alzheimer's disease","volume":"19","author":"Juottonen","year":"1998","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2025.100969_bib58","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1016\/j.jalz.2007.08.004","article-title":"Inflammation and Alzheimer's disease: possible role of periodontal diseases","volume":"4","author":"Kamer","year":"2008","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2025.100969_bib59","doi-asserted-by":"crossref","first-page":"18561","DOI":"10.1038\/s41598-020-75517-4","article-title":"Microglial response to experimental periodontitis in a murine model of Alzheimer's disease","volume":"10","author":"Kantarci","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2025.100969_bib60","doi-asserted-by":"crossref","first-page":"6555","DOI":"10.1038\/s41598-019-43076-y","article-title":"Synapse loss and progress of Alzheimer's disease -A network model","volume":"9","author":"Kashyap","year":"2019","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2025.100969_bib61","doi-asserted-by":"crossref","first-page":"1862","DOI":"10.4049\/jimmunol.0803007","article-title":"The mechanism of osteoclast differentiation induced by IL-1","volume":"183","author":"Kim","year":"2009","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbih.2025.100969_bib62","doi-asserted-by":"crossref","first-page":"575","DOI":"10.1016\/j.trci.2018.06.014","article-title":"Inflammation as a central mechanism in Alzheimer's disease","volume":"4","author":"Kinney","year":"2018","journal-title":"Alzheimers Dement (N Y)"},{"key":"10.1016\/j.bbih.2025.100969_bib63","doi-asserted-by":"crossref","first-page":"8843","DOI":"10.1523\/JNEUROSCI.2868-05.2005","article-title":"Lipopolysaccharide-induced inflammation exacerbates tau pathology by a cyclin-dependent kinase 5-mediated pathway in a transgenic model of Alzheimer's disease","volume":"25","author":"Kitazawa","year":"2005","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib64","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/978-1-4939-8994-2_10","article-title":"The Y-maze for assessment of spatial working and reference memory in mice","volume":"1916","author":"Kraeuter","year":"2019","journal-title":"Methods Mol. Biol."},{"key":"10.1016\/j.bbih.2025.100969_bib65","doi-asserted-by":"crossref","first-page":"e1007","DOI":"10.1212\/WNL.0000000000007032","article-title":"Blood neurofilament light chain as a biomarker of MS disease activity and treatment response","volume":"92","author":"Kuhle","year":"2019","journal-title":"Neurology"},{"key":"10.1016\/j.bbih.2025.100969_bib66","doi-asserted-by":"crossref","first-page":"796","DOI":"10.1523\/JNEUROSCI.3501-06.2007","article-title":"Abeta oligomer-induced aberrations in synapse composition, shape, and density provide a molecular basis for loss of connectivity in Alzheimer's disease","volume":"27","author":"Lacor","year":"2007","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib67","doi-asserted-by":"crossref","first-page":"173","DOI":"10.3389\/fnsys.2015.00173","article-title":"The role of prefrontal cortex in working memory: a mini review","volume":"9","author":"Lara","year":"2015","journal-title":"Front. Syst. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib68","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1111\/jgs.14449","article-title":"Periodontitis as a modifiable risk factor for dementia: a nationwide population-based cohort study","volume":"65","author":"Lee","year":"2017","journal-title":"J. Am. Geriatr. Soc."},{"key":"10.1016\/j.bbih.2025.100969_bib69","doi-asserted-by":"crossref","first-page":"444","DOI":"10.3389\/fbioe.2020.00444","article-title":"A simplified and effective method for generation of experimental murine periodontitis model","volume":"8","author":"Li","year":"2020","journal-title":"Front. Bioeng. Biotechnol."},{"key":"10.1016\/j.bbih.2025.100969_bib70","doi-asserted-by":"crossref","first-page":"1254","DOI":"10.2174\/1567205017666200103111253","article-title":"Midlife modifiable risk factors for dementia: a systematic review and meta-analysis of 34 prospective cohort studies","volume":"16","author":"Li","year":"2019","journal-title":"Curr. Alzheimer Res."},{"key":"10.1016\/j.bbih.2025.100969_bib71","doi-asserted-by":"crossref","first-page":"17423","DOI":"10.1038\/s41598-024-67177-5","article-title":"Peripheral inflammation is associated with brain atrophy and cognitive decline linked to mild cognitive impairment and Alzheimer's disease","volume":"14","author":"Liang","year":"2024","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2025.100969_bib72","doi-asserted-by":"crossref","first-page":"683","DOI":"10.3389\/fphys.2020.00683","article-title":"Potential bidirectional relationship between periodontitis and alzheimer's disease","volume":"11","author":"Liccardo","year":"2020","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbih.2025.100969_bib73","article-title":"Application of ligature-induced periodontitis in mice to explore the molecular mechanism of periodontal disease","volume":"22","author":"Lin","year":"2021","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbih.2025.100969_bib74","article-title":"Novel object recognition test for the investigation of learning and memory in mice","volume":"126","author":"Lueptow","year":"2017","journal-title":"J. Vis. Exp."},{"key":"10.1016\/j.bbih.2025.100969_bib75","first-page":"6605","article-title":"TNF-alpha and RANKL promote osteoclastogenesis by upregulating RANK via the NF-kappaB pathway","volume":"17","author":"Luo","year":"2018","journal-title":"Mol. Med. Rep."},{"key":"10.1016\/j.bbih.2025.100969_bib76","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1038\/s41398-021-01349-z","article-title":"Pro-inflammatory interleukin-6 signaling links cognitive impairments and peripheral metabolic alterations in Alzheimer's disease","volume":"11","author":"Lyra e Silva","year":"2021","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbih.2025.100969_bib77","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1177\/00220345211037220","article-title":"Dementia and the risk of periodontitis: a population-based cohort study","volume":"101","author":"Ma","year":"2022","journal-title":"J. Dent. Res."},{"key":"10.1016\/j.bbih.2025.100969_bib78","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1016\/j.bbi.2024.07.021","article-title":"Short-term high fat diet impairs memory, exacerbates the neuroimmune response, and evokes synaptic degradation via a complement-dependent mechanism in a mouse model of Alzheimer's disease","volume":"121","author":"Mackey-Alfonso","year":"2024","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2025.100969_bib79","doi-asserted-by":"crossref","first-page":"2247","DOI":"10.1038\/s41596-018-0035-4","article-title":"An experimental murine model to study periodontitis","volume":"13","author":"Marchesan","year":"2018","journal-title":"Nat. Protoc."},{"key":"10.1016\/j.bbih.2025.100969_bib80","doi-asserted-by":"crossref","first-page":"709438","DOI":"10.3389\/fphys.2021.709438","article-title":"Periodontal inflammation and systemic diseases: an overview","volume":"12","author":"Martinez-Garcia","year":"2021","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbih.2025.100969_bib81","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1111\/jre.12344","article-title":"Ligature-induced periodontitis in mice induces elevated levels of circulating interleukin-6 but shows only weak effects on adipose and liver tissues","volume":"51","author":"Matsuda","year":"2016","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.bbih.2025.100969_bib82","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0258823","article-title":"Role of TLR4 signaling on Porphyromonas gingivalis LPS-induced cardiac dysfunction in mice","volume":"17","author":"Matsuo","year":"2022","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2025.100969_bib83","doi-asserted-by":"crossref","first-page":"1519","DOI":"10.1093\/brain\/122.8.1519","article-title":"Neocortical and hippocampal glucose hypometabolism following neurotoxic lesions of the entorhinal and perirhinal cortices in the non-human primate as shown by PET: implications for Alzheimer's disease","volume":"122","author":"Meguro","year":"1999","journal-title":"Brain"},{"key":"10.1016\/j.bbih.2025.100969_bib84","doi-asserted-by":"crossref","DOI":"10.3390\/pathogens9110944","article-title":"Porphyromonas gingivalis and its systemic impact: current status","volume":"9","author":"Mei","year":"2020","journal-title":"Pathogens"},{"key":"10.1016\/j.bbih.2025.100969_bib85","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1016\/j.jalz.2019.03.012","article-title":"Association of TLR4 with Alzheimer's disease risk and presymptomatic biomarkers of inflammation","volume":"15","author":"Miron","year":"2019","journal-title":"Alzheimers Dement"},{"key":"10.1016\/j.bbih.2025.100969_bib86","doi-asserted-by":"crossref","first-page":"174506","DOI":"10.1016\/j.ejphar.2021.174506","article-title":"Morin attenuates memory deficits in a rat model of Alzheimer's disease by ameliorating oxidative stress and neuroinflammation","volume":"910","author":"Mohammadi","year":"2021","journal-title":"Eur. J. Pharmacol."},{"key":"10.1016\/j.bbih.2025.100969_bib87","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1083\/jcb.139.1.193","article-title":"Synaptopodin: an actin-associated protein in telencephalic dendrites and renal podocytes","volume":"139","author":"Mundel","year":"1997","journal-title":"J. Cell Biol."},{"key":"10.1016\/j.bbih.2025.100969_bib88","doi-asserted-by":"crossref","first-page":"47","DOI":"10.3233\/BPL-210127","article-title":"The perfect cytokine storm: how peripheral immune challenges impact brain plasticity & memory function in aging","volume":"7","author":"Muscat","year":"2021","journal-title":"Brain Plast."},{"key":"10.1016\/j.bbih.2025.100969_bib89","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1523\/JNEUROSCI.1151-22.2022","article-title":"Selective TLR4 antagonism prevents and reverses morphine-induced persistent postoperative cognitive dysfunction, dysregulation of synaptic elements, and impaired BDNF signaling in aged male rats","volume":"43","author":"Muscat","year":"2023","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib90","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1007\/s12035-012-8324-3","article-title":"Targeting synaptic dysfunction in Alzheimer's disease therapy","volume":"46","author":"Nistic\u00f2","year":"2012","journal-title":"Mol. Neurobiol."},{"key":"10.1016\/j.bbih.2025.100969_bib91","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.neuropharm.2014.10.028","article-title":"Microglial priming and enhanced reactivity to secondary insult in aging, and traumatic CNS injury, and neurodegenerative disease","volume":"96","author":"Norden","year":"2015","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbih.2025.100969_bib92","doi-asserted-by":"crossref","first-page":"680","DOI":"10.15585\/mmwr.mm7120a2","article-title":"Modifiable risk factors for alzheimer disease and related dementias among adults aged >\/=45 Years - United States, 2019","volume":"71","author":"Omura","year":"2022","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"key":"10.1016\/j.bbih.2025.100969_bib93","doi-asserted-by":"crossref","first-page":"758","DOI":"10.4049\/jimmunol.156.2.758","article-title":"IL-13 and IL-4 inhibit bone resorption by suppressing cyclooxygenase-2-dependent prostaglandin synthesis in osteoblasts","volume":"156","author":"Onoe","year":"1996","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbih.2025.100969_bib94","doi-asserted-by":"crossref","first-page":"312","DOI":"10.1186\/s12974-021-02332-7","article-title":"Biologic TNF-\u03b1 inhibitors reduce microgliosis, neuronal loss, and tau phosphorylation in a transgenic mouse model of tauopathy","volume":"18","author":"Ou","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2025.100969_bib95","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1111\/j.1600-0765.1991.tb01649.x","article-title":"The role of inflammatory mediators in the pathogenesis of periodontal disease","volume":"26","author":"Page","year":"1991","journal-title":"J. Periodontal. Res."},{"key":"10.1016\/j.bbih.2025.100969_bib96","first-page":"1322","article-title":"Utilizing electronic dental records to predict neuro-degenerative diseases in a dental setting: a pilot study","volume":"310","author":"Patel","year":"2024","journal-title":"Stud Health Technol Inform"},{"key":"10.1016\/j.bbih.2025.100969_bib97","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1002\/msj.20157","article-title":"Neuropathology of Alzheimer's disease","volume":"77","author":"Perl","year":"2010","journal-title":"Mt. Sinai J. Med."},{"key":"10.1016\/j.bbih.2025.100969_bib98","doi-asserted-by":"crossref","DOI":"10.3390\/ijms25084504","article-title":"Periodontitis: a plausible modifiable risk factor for neurodegenerative diseases? A comprehensive review","volume":"25","author":"Plachokova","year":"2024","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbih.2025.100969_bib99","doi-asserted-by":"crossref","first-page":"437","DOI":"10.31887\/DCNS.2016.18.4\/cepperson","article-title":"Considering sex and gender in Alzheimer disease and other dementias","volume":"18","author":"Podcasy","year":"2016","journal-title":"Dialogues Clin. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib100","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1111\/j.1600-051X.2009.01393.x","article-title":"Mouse model of experimental periodontitis induced by Porphyromonas gingivalis\/Fusobacterium nucleatum infection: bone loss and host response","volume":"36","author":"Polak","year":"2009","journal-title":"J. Clin. Periodontol."},{"key":"10.1016\/j.bbih.2025.100969_bib101","doi-asserted-by":"crossref","first-page":"1197","DOI":"10.1021\/acschemneuro.8b00511","article-title":"Inhibition of LTP-induced translation by IL-1\u03b2 reduces the level of newly synthesized proteins in hippocampal dendrites","volume":"10","author":"Prieto","year":"2019","journal-title":"ACS Chem. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib102","doi-asserted-by":"crossref","first-page":"e3162","DOI":"10.21769\/BioProtoc.3162","article-title":"Assessing spatial working memory using the spontaneous alternation Y-maze test in aged male mice","volume":"9","author":"Prieur","year":"2019","journal-title":"Bio Protoc"},{"key":"10.1016\/j.bbih.2025.100969_bib103","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1038\/s41522-023-00462-9","article-title":"Periodontitis salivary microbiota exacerbates colitis-induced anxiety-like behavior via gut microbiota","volume":"9","author":"Qian","year":"2023","journal-title":"NPJ Biofilms Microbiomes"},{"key":"10.1016\/j.bbih.2025.100969_bib104","doi-asserted-by":"crossref","first-page":"903","DOI":"10.1007\/s11064-012-0708-2","article-title":"Neuroinflammation and synaptic loss","volume":"37","author":"Rao","year":"2012","journal-title":"Neurochem. Res."},{"key":"10.1016\/j.bbih.2025.100969_bib105","doi-asserted-by":"crossref","DOI":"10.3390\/molecules27103194","article-title":"Neuroinflammatory markers: key indicators in the pathology of neurodegenerative diseases","volume":"27","author":"Rauf","year":"2022","journal-title":"Molecules"},{"key":"10.1016\/j.bbih.2025.100969_bib106","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0166-4328(02)00272-3","article-title":"Glutamate receptor function in learning and memory","volume":"140","author":"Riedel","year":"2003","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2025.100969_bib107","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/bpa.12785","article-title":"Distinct disease-sensitive GABAergic neurons in the perirhinal cortex of Alzheimer's mice and patients","volume":"30","author":"Sanchez-Mejias","year":"2020","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbih.2025.100969_bib108","doi-asserted-by":"crossref","first-page":"2436","DOI":"10.1128\/IAI.06276-11","article-title":"Fusobacterium nucleatum and Tannerella forsythia induce synergistic alveolar bone loss in a mouse periodontitis model","volume":"80","author":"Settem","year":"2012","journal-title":"Infect. Immun."},{"key":"10.1016\/j.bbih.2025.100969_bib109","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1742-2094-5-7","article-title":"The role of interleukin-1 in neuroinflammation and Alzheimer disease: an evolving perspective","volume":"5","author":"Shaftel","year":"2008","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2025.100969_bib110","doi-asserted-by":"crossref","first-page":"323","DOI":"10.1159\/000156474","article-title":"Neuroinflammation associated with aging sensitizes the brain to the effects of infection or stress","volume":"15","author":"Sparkman","year":"2008","journal-title":"Neuroimmunomodulation"},{"key":"10.1016\/j.bbih.2025.100969_bib111","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.bbr.2015.04.012","article-title":"Early detection of cognitive deficits in the 3xTg-AD mouse model of Alzheimer's disease","volume":"289","author":"Stover","year":"2015","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2025.100969_bib112","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1186\/s13195-023-01162-4","article-title":"Molecular insights into sex-specific metabolic alterations in Alzheimer's mouse brain using multi-omics approach","volume":"15","author":"Strefeler","year":"2023","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bbih.2025.100969_bib113","doi-asserted-by":"crossref","first-page":"592607","DOI":"10.3389\/fncel.2020.592607","article-title":"Synaptic loss in alzheimer's disease: mechanistic insights provided by two-photon in vivo imaging of transgenic mouse models","volume":"14","author":"Subramanian","year":"2020","journal-title":"Front. Cell. Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib114","doi-asserted-by":"crossref","first-page":"14711","DOI":"10.1038\/s41598-020-71528-3","article-title":"Mechanism underlying hippocampal long-term potentiation and depression based on competition between endocytosis and exocytosis of AMPA receptors","volume":"10","author":"Sumi","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2025.100969_bib115","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1016\/j.neuint.2006.05.004","article-title":"Selective loss of synaptic proteins in Alzheimer's disease: evidence for an increased severity with APOE \u025b4","volume":"49","author":"Tannenberg","year":"2006","journal-title":"Neurochem. Int."},{"key":"10.1016\/j.bbih.2025.100969_bib116","doi-asserted-by":"crossref","first-page":"491","DOI":"10.1016\/j.cden.2005.03.001","article-title":"Etiology and pathogenesis of periodontal diseases","volume":"49","author":"Tatakis","year":"2005","journal-title":"Dent Clin North Am"},{"key":"10.1016\/j.bbih.2025.100969_bib117","doi-asserted-by":"crossref","first-page":"327","DOI":"10.3389\/fnagi.2017.00327","article-title":"Periodontitis and alzheimer's disease: a possible comorbidity between oral chronic inflammatory condition and neuroinflammation","volume":"9","author":"Teixeira","year":"2017","journal-title":"Front. Aging Neurosci."},{"key":"10.1016\/j.bbih.2025.100969_bib118","doi-asserted-by":"crossref","first-page":"437","DOI":"10.4103\/njms.njms_384_21","article-title":"Periodontal status of patients with nontubercular respiratory diseases hospitalized in a tertiary care hospital","volume":"13","author":"Verma","year":"2022","journal-title":"Natl. J. Maxillofac. Surg."},{"key":"10.1016\/j.bbih.2025.100969_bib119","doi-asserted-by":"crossref","first-page":"1148","DOI":"10.14283\/jpad.2024.79","article-title":"Periodontal disease and alzheimer's: insights from a systematic literature network analysis","volume":"11","author":"Villar","year":"2024","journal-title":"J Prev Alzheimers Dis"},{"key":"10.1016\/j.bbih.2025.100969_bib120","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.3233\/JAD-160763","article-title":"Role of glutamate and NMDA receptors in alzheimer's disease","volume":"57","author":"Wang","year":"2017","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2025.100969_bib121","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.bbi.2019.07.002","article-title":"Systemic inflammation linking chronic periodontitis to cognitive decline","volume":"81","author":"Wang","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2025.100969_bib122","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1186\/s12974-023-02747-4","article-title":"IL-1beta and TNF-alpha play an important role in modulating the risk of periodontitis and Alzheimer's disease","volume":"20","author":"Wang","year":"2023","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2025.100969_bib123","series-title":"Dementia Key Facts","author":"WHO","year":"2019"},{"key":"10.1016\/j.bbih.2025.100969_bib124","doi-asserted-by":"crossref","first-page":"3500","DOI":"10.1073\/pnas.83.10.3500","article-title":"Synaptophysin: a marker protein for neuroendocrine cells and neoplasms","volume":"83","author":"Wiedenmann","year":"1986","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbih.2025.100969_bib125","doi-asserted-by":"crossref","first-page":"16150","DOI":"10.1074\/jbc.M117.782490","article-title":"Postsynaptic density 95 (PSD-95) serine 561 phosphorylation regulates a conformational switch and bidirectional dendritic spine structural plasticity","volume":"292","author":"Wu","year":"2017","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbih.2025.100969_bib126","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/j.bbr.2014.02.002","article-title":"Rutin improves spatial memory in Alzheimer's disease transgenic mice by reducing A\u03b2 oligomer level and attenuating oxidative stress and neuroinflammation","volume":"264","author":"Xu","year":"2014","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2025.100969_bib127","first-page":"1299","article-title":"Meta-analysis of modifiable risk factors for Alzheimer's disease","volume":"86","author":"Xu","year":"2015","journal-title":"J. Neurol. Neurosurg. Psychiatry"},{"key":"10.1016\/j.bbih.2025.100969_bib128","first-page":"1555","article-title":"The role of SIRT1 in neuroinflammation and cognitive dysfunction in aged rats after anesthesia and surgery","volume":"11","author":"Yan","year":"2019","journal-title":"Am J Transl Res"},{"key":"10.1016\/j.bbih.2025.100969_bib129","doi-asserted-by":"crossref","first-page":"505","DOI":"10.3233\/JAD-220475","article-title":"Inflammation disrupts cognitive integrity via plasma neurofilament light chain coupling brain networks in alzheimer's disease","volume":"89","author":"Yao","year":"2022","journal-title":"J Alzheimers Dis"},{"key":"10.1016\/j.bbih.2025.100969_bib130","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s12974-020-02065-z","article-title":"Microglial activation contributes to cognitive impairments in rotenone-induced mouse Parkinson's disease model","volume":"18","author":"Zhang","year":"2021","journal-title":"J. Neuroinflammation"},{"key":"10.1016\/j.bbih.2025.100969_bib131","doi-asserted-by":"crossref","first-page":"801","DOI":"10.3233\/JAD-2012-120151","article-title":"Novel object recognition as a facile behavior test for evaluating drug effects in AbetaPP\/PS1 Alzheimer's disease mouse model","volume":"31","author":"Zhang","year":"2012","journal-title":"J Alzheimers Dis"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354625000274?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354625000274?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:10:57Z","timestamp":1778919057000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354625000274"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,3]]},"references-count":131,"alternative-id":["S2666354625000274"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2025.100969","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2025,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Ligature-induced periodontitis in a transgenic mouse model of Alzheimer's disease dysregulates neuroinflammation, exacerbates cognitive impairment, and accelerates amyloid pathology","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2025.100969","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100969"}}