{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:40:26Z","timestamp":1781880026927,"version":"3.54.5"},"reference-count":29,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,5,1]],"date-time":"2025-05-01T00:00:00Z","timestamp":1746057600000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,3,6]],"date-time":"2025-03-06T00:00:00Z","timestamp":1741219200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R01AG053582"],"award-info":[{"award-number":["R01AG053582"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["R21AG073750"],"award-info":[{"award-number":["R21AG073750"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2025,5]]},"DOI":"10.1016\/j.bbih.2025.100974","type":"journal-article","created":{"date-parts":[[2025,3,7]],"date-time":"2025-03-07T17:18:49Z","timestamp":1741367929000},"page":"100974","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":6,"special_numbering":"C","title":["Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery"],"prefix":"10.1016","volume":"45","author":[{"given":"Christopher","family":"Simon","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Occam Kelly","family":"Graves","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oluwaseun","family":"Akeju","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tina B.","family":"McKay","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2025.100974_bib1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1186\/s40478-023-01625-7","article-title":"Traumatic brain injury induces TDP-43 mislocalization and neurodegenerative effects in tissue distal to the primary injury site in a non-transgenic mouse","volume":"11","author":"Bjorklund","year":"2023","journal-title":"Acta Neuropathol. commun."},{"key":"10.1016\/j.bbih.2025.100974_bib2","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1016\/j.molmed.2011.06.004","article-title":"TDP-43 functions and pathogenic mechanisms implicated in TDP-43 proteinopathies","volume":"17","author":"Cohen","year":"2011","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbih.2025.100974_bib3","doi-asserted-by":"crossref","first-page":"1978","DOI":"10.1038\/s41598-021-81599-5","article-title":"Serum naturally occurring anti-TDP-43 auto-antibodies are increased in amyotrophic lateral sclerosis","volume":"11","author":"Conti","year":"2021","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2025.100974_bib4","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0140248","article-title":"Inflammation induces TDP-43 mislocalization and aggregation","volume":"10","author":"Correia","year":"2015","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2025.100974_bib5","doi-asserted-by":"crossref","first-page":"2809","DOI":"10.1093\/brain\/aws190","article-title":"Delirium is a strong risk factor for dementia in the oldest-old: a population-based cohort study","volume":"135","author":"Davis","year":"2012","journal-title":"Brain"},{"key":"10.1016\/j.bbih.2025.100974_bib6","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/jnen\/nlaa162","article-title":"TDP-43 vasculopathy in the spinal cord in sporadic amyotrophic lateral sclerosis (sALS) and frontal cortex in sALS\/FTLD-TDP","volume":"80","author":"Ferrer","year":"2021","journal-title":"J. Neuropathol. Exp. Neurol."},{"key":"10.1016\/j.bbih.2025.100974_bib7","doi-asserted-by":"crossref","first-page":"823","DOI":"10.1016\/S1474-4422(15)00101-5","article-title":"The interface between delirium and dementia in elderly adults","volume":"14","author":"Fong","year":"2015","journal-title":"Lancet Neurol."},{"key":"10.1016\/j.bbih.2025.100974_bib8","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1038\/s41582-022-00698-7","article-title":"The inter-relationship between delirium and dementia: the importance of delirium prevention","volume":"18","author":"Fong","year":"2022","journal-title":"Nat. Rev. Neurol."},{"key":"10.1016\/j.bbih.2025.100974_bib9","doi-asserted-by":"crossref","first-page":"803","DOI":"10.1176\/appi.ajp.2008.08020181","article-title":"Postoperative delirium","volume":"165","author":"Fricchione","year":"2008","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.bbih.2025.100974_bib10","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1016\/j.jad.2019.03.024","article-title":"Serum levels of TDP-43 in late-life patients with depressive episode","volume":"250","author":"Ichikawa","year":"2019","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbih.2025.100974_bib11","doi-asserted-by":"crossref","first-page":"911","DOI":"10.1016\/S0140-6736(13)60688-1","article-title":"Delirium in elderly people","volume":"383","author":"Inouye","year":"2014","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2025.100974_bib12","doi-asserted-by":"crossref","first-page":"382","DOI":"10.1038\/s41591-023-02788-5","article-title":"A fluid biomarker reveals loss of TDP-43 splicing repression in presymptomatic ALS\u2013FTD","volume":"30","author":"Irwin","year":"2024","journal-title":"Nat. Med."},{"key":"10.1016\/j.bbih.2025.100974_bib13","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1186\/s13195-022-01091-8","article-title":"Serum total TDP-43 levels are decreased in frontotemporal dementia patients with C9orf72 repeat expansion or concomitant motoneuron disease phenotype","volume":"14","author":"Katisko","year":"2022","journal-title":"Alzheimers Res. Ther."},{"key":"10.1016\/j.bbih.2025.100974_bib14","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1007\/s00401-019-02077-x","article-title":"The basis of clinicopathological heterogeneity in TDP-43 proteinopathy","volume":"138","author":"Kawakami","year":"2019","journal-title":"Acta Neuropathol."},{"key":"10.1016\/j.bbih.2025.100974_bib15","doi-asserted-by":"crossref","first-page":"950","DOI":"10.1097\/ALN.0000000000004922","article-title":"Serum neurofilament light and postoperative delirium in cardiac surgery: a preplanned secondary analysis of a prospective observational study","volume":"140","author":"Khalifa","year":"2024","journal-title":"Anesthesiology"},{"key":"10.1016\/j.bbih.2025.100974_bib16","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1097\/CCM.0000000000002483","article-title":"Preoperative cognitive performance and postoperative delirium are independently associated with future dementia in older people who have undergone cardiac surgery: a longitudinal cohort study","volume":"45","author":"Lingehall","year":"2017","journal-title":"Crit. Care Med."},{"key":"10.1016\/j.bbih.2025.100974_bib17","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s40035-024-00419-8","article-title":"In vivo diagnosis of TDP-43 proteinopathies: in search of biomarkers of clinical use","volume":"13","author":"L\u00f3pez-Carbonero","year":"2024","journal-title":"Transl. Neurodegener."},{"key":"10.1016\/j.bbih.2025.100974_bib18","doi-asserted-by":"crossref","first-page":"1281","DOI":"10.1093\/gerona\/61.12.1281","article-title":"Serum biomarkers for delirium","volume":"61","author":"Marcantonio","year":"2006","journal-title":"J. Gerontol. Series A: Biol. Sci. Med. Sci."},{"key":"10.1016\/j.bbih.2025.100974_bib19","doi-asserted-by":"crossref","first-page":"1266","DOI":"10.1152\/physiol.2024.39.S1.1266","article-title":"Investigating the role of TDP-43 microvasculopathy on neurovascular unit function in the setting of COVID-19 and alzheimer's disease and related dementias","volume":"39","author":"Mathew","year":"2024","journal-title":"Physiology"},{"key":"10.1016\/j.bbih.2025.100974_bib20","doi-asserted-by":"crossref","first-page":"e13","DOI":"10.1016\/j.bja.2022.04.002","article-title":"Tau as a serum biomarker of delirium after major cardiac surgery: a single centre case-control study","volume":"129","author":"McKay","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbih.2025.100974_bib21","doi-asserted-by":"crossref","first-page":"286","DOI":"10.1111\/nan.12430","article-title":"Prevalence of transactive response DNA\u2010binding protein 43 (TDP\u201043) proteinopathy in cognitively normal older adults: systematic review and meta\u2010analysis","volume":"44","author":"Nascimento","year":"2018","journal-title":"Neuropathol. Appl. Neurobiol."},{"key":"10.1016\/j.bbih.2025.100974_bib22","doi-asserted-by":"crossref","first-page":"1306","DOI":"10.1056\/NEJMoa1301372","article-title":"Long-term cognitive impairment after critical illness","volume":"369","author":"Pandharipande","year":"2013","journal-title":"N. Engl. J. Med."},{"key":"10.1016\/j.bbih.2025.100974_bib23","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/j.bja.2021.11.041","article-title":"Influence of perioperative dexmedetomidine on the incidence of postoperative delirium in adult patients undergoing cardiac surgery","volume":"129","author":"Patel","year":"2022","journal-title":"Br. J. Anaesth."},{"key":"10.1016\/j.bbih.2025.100974_bib24","article-title":"Nighttime dexmedetomidine for delirium prevention in non-mechanically ventilated patients after cardiac surgery (MINDDS): a single-centre, parallel-arm, randomised, placebo-controlled superiority trial","volume":"56","author":"Qu","year":"2023","journal-title":"E. Clin. Med."},{"key":"10.1016\/j.bbih.2025.100974_bib25","doi-asserted-by":"crossref","first-page":"4649","DOI":"10.1002\/alz.13896","article-title":"Entorhinal vessel density correlates with phosphorylated tau and TDP\u201043 pathology","volume":"20","author":"Rodr\u00edguez","year":"2024","journal-title":"Alzheimer's Dementia"},{"key":"10.1016\/j.bbih.2025.100974_bib26","article-title":"Perivascular phosphorylated TDP\u201043 inclusions are associated with Alzheimer's disease pathology and loss of CD146 and Aquaporin\u20104","author":"Santiago","year":"2024","journal-title":"Brain Pathol."},{"key":"10.1016\/j.bbih.2025.100974_bib27","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2017-020316","article-title":"Minimizing ICU Neurological Dysfunction with Dexmedetomidine-induced Sleep (MINDDS): protocol for a randomised, double-blind, parallel-arm, placebo-controlled trial","volume":"8","author":"Shelton","year":"2018","journal-title":"BMJ Open"},{"key":"10.1016\/j.bbih.2025.100974_bib28","first-page":"1097","article-title":"Serum transactive response DNA binding protein 43 associates with poor short-term neurologic outcome after return of spontaneous circulation following cardiac arrest","volume":"10","author":"Sun","year":"2023","journal-title":"Shock"},{"key":"10.1016\/j.bbih.2025.100974_bib29","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1038\/s41572-020-00223-4","article-title":"Delirium","volume":"6","author":"Wilson","year":"2020","journal-title":"Nat. Rev. Dis. Primers"}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354625000328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354625000328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,4,25]],"date-time":"2025-04-25T01:40:44Z","timestamp":1745545244000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354625000328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,5]]},"references-count":29,"alternative-id":["S2666354625000328"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2025.100974","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2025,5]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Elevated TDP-43 serum levels associated with postoperative delirium following major cardiac surgery","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2025.100974","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"100974"}}