{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T20:26:10Z","timestamp":1791491170758,"version":"4.3.4"},"reference-count":76,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T00:00:00Z","timestamp":1751328000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,5,19]],"date-time":"2025-05-19T00:00:00Z","timestamp":1747612800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100021202","name":"Alliance de recherche num\u00e9rique du Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100021202","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000192","name":"Ontario Ministry of Economic Development and Innovation","doi-asserted-by":"publisher","award":["13440"],"award-info":[{"award-number":["13440"]}],"id":[{"id":"10.13039\/501100000192","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000038","name":"Natural Sciences and Engineering Research Council of Canada","doi-asserted-by":"publisher","award":["2020-04302"],"award-info":[{"award-number":["2020-04302"]}],"id":[{"id":"10.13039\/501100000038","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000092","name":"Ontario Genomics Institute","doi-asserted-by":"publisher","award":["OGI-149"],"award-info":[{"award-number":["OGI-149"]}],"id":[{"id":"10.13039\/501100000092","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100008762","name":"Genome Canada","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008762","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000024","name":"Canadian Institutes of Health Research","doi-asserted-by":"publisher","award":["ECD-144627"],"award-info":[{"award-number":["ECD-144627"]}],"id":[{"id":"10.13039\/501100000024","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2025,7]]},"DOI":"10.1016\/j.bbih.2025.101023","type":"journal-article","created":{"date-parts":[[2025,5,20]],"date-time":"2025-05-20T05:19:40Z","timestamp":1747718380000},"page":"101023","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":2,"special_numbering":"C","title":["Modulating effects of environmental enrichment on stress-induced changes in the gut microbiome"],"prefix":"10.1016","volume":"46","author":[{"given":"Kevin B.","family":"Smith","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Murack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Butcher","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Abby","family":"Hinterberger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Stintzi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacky","family":"Liang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Despina A.","family":"Tata","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0449-0217","authenticated-orcid":false,"given":"Nafissa","family":"Ismail","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2025.101023_bib1","doi-asserted-by":"crossref","first-page":"56","DOI":"10.3892\/br.2020.1363","article-title":"Examining the central effects of chronic stressful social isolation on rats","volume":"13","author":"Alshammari","year":"2020","journal-title":"Biomed. Rep"},{"key":"10.1016\/j.bbih.2025.101023_bib2","doi-asserted-by":"crossref","first-page":"381","DOI":"10.1080\/10253890701824051","article-title":"Effects of social isolation and environmental enrichment on atherosclerosis in ApoE\u2212\/\u2212 mice: research Report","volume":"11","author":"Bernberg","year":"2008","journal-title":"Stress"},{"key":"10.1016\/j.bbih.2025.101023_bib3","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1210\/edrv-17-1-64","article-title":"Immune-neuro-endocrine interactions: facts and hypotheses","volume":"17","author":"Besedovsky","year":"1996","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbih.2025.101023_bib4","doi-asserted-by":"crossref","first-page":"926","DOI":"10.1002\/hbm.21052","article-title":"The role of puberty in the developing adolescent brain","volume":"31","author":"Blakemore","year":"2010","journal-title":"Hum. Brain Mapp."},{"issue":"6","key":"10.1016\/j.bbih.2025.101023_bib77","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0031-9384(95)02043-8","article-title":"Effects of housing on male and female rats: Crowding stresses males but calms females","volume":"58","author":"Brown","year":"1995","journal-title":"Physiol. Behav"},{"key":"10.1016\/j.bbih.2025.101023_bib5","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.bbi.2016.08.002","article-title":"Age and sex differences in immune response following LPS treatment in mice","volume":"58","author":"Cai","year":"2016","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2025.101023_bib6","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1038\/nmeth.3869","article-title":"DADA2: high-resolution sample inference from Illumina amplicon data","volume":"13","author":"Callahan","year":"2016","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbih.2025.101023_bib7","doi-asserted-by":"crossref","first-page":"3401","DOI":"10.1016\/j.celrep.2019.05.042","article-title":"Dynamic and asymmetric changes of the microbial communities after cohousing in laboratory mice","volume":"27","author":"Caruso","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.bbih.2025.101023_bib8","doi-asserted-by":"crossref","first-page":"60","DOI":"10.1016\/j.neurobiolaging.2016.08.019","article-title":"Association of brain amyloidosis with pro-inflammatory gut bacterial taxa and peripheral inflammation markers in cognitively impaired elderly","volume":"49","author":"Cattaneo","year":"2017","journal-title":"Neurobiol. Aging"},{"key":"10.1016\/j.bbih.2025.101023_bib9","article-title":"Gut microbiome alterations precede cerebral amyloidosis and microglial pathology in a mouse model of alzheimer's disease","author":"Chen","year":"2020","journal-title":"BioMed Res. Int."},{"key":"10.1016\/j.bbih.2025.101023_bib10","first-page":"1258","article-title":"Interferon \u03b3 induces translocation of commensal Escherichia coli across gut epithelial cells via a lipid raft--mediated process","volume":"128","author":"Clark","year":"2005","journal-title":"Gastroenterology (New York, N. Y., 1943)"},{"key":"10.1016\/j.bbih.2025.101023_bib11","doi-asserted-by":"crossref","first-page":"e73","DOI":"10.1038\/cti.2016.17","article-title":"Regulation of immune cell function by short-chain fatty acids","volume":"5","author":"Corr\u00eaa-Oliveira","year":"2016","journal-title":"Clin. Transl. Immunol."},{"key":"10.1016\/j.bbih.2025.101023_bib12","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.pbb.2006.12.001","article-title":"Adolescent cortical development: a critical period of vulnerability for addiction","volume":"86","author":"Crews","year":"2007","journal-title":"Pharmacol. Biochem. Behav."},{"key":"10.1016\/j.bbih.2025.101023_bib13","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1152\/physrev.00039.2016","article-title":"Neuroimmune interactions: from the brain to the immune system and vice versa","volume":"98","author":"Dantzer","year":"2018","journal-title":"Physiol. Rev."},{"key":"10.1016\/j.bbih.2025.101023_bib14","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1016\/j.psyneuen.2012.03.007","article-title":"Regulation of the stress response by the gut microbiota: implications for psychoneuroendocrinology","volume":"37","author":"Dinan","year":"2012","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2025.101023_bib15","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.bpsgos.2023.04.007","article-title":"Chronic stress exposure alters the gut barrier: sex-specific effects on microbiota and jejunum tight junctions","volume":"4","author":"Doney","year":"2024","journal-title":"Biol. Psychiatry Glob. Open Sci."},{"key":"10.1016\/j.bbih.2025.101023_bib16","doi-asserted-by":"crossref","DOI":"10.1016\/j.yfrne.2020.100896","article-title":"Do different types of stress differentially alter behavioural and neurobiological outcomes associated with depression in rodent models? A systematic review","volume":"61","author":"Du Preez","year":"2021","journal-title":"Front. Neuroendocrinol."},{"key":"10.1016\/j.bbih.2025.101023_bib17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.bbr.2005.06.025","article-title":"Effects of social and physical enrichment on open field activity differ in male and female Sprague-Dawley rats","volume":"165","author":"Elliott","year":"2005","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2025.101023_bib18","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1016\/j.neures.2021.04.007","article-title":"Environmental enrichment modulates HPA axis reprogramming in adult male rats exposed to early adolescent stress","volume":"172","author":"Fan","year":"2021","journal-title":"Neurosci. Res."},{"key":"10.1016\/j.bbih.2025.101023_bib78","series-title":"The Mouse Brain in Stereotaxic Coordinates","author":"Franklin","year":"1997"},{"key":"10.1016\/j.bbih.2025.101023_bib19","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/j.neuroscience.2015.06.035","article-title":"Age and sex differences in c-Fos expression and serum corticosterone concentration following LPS treatment","volume":"305","author":"Girard-Joyal","year":"2015","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbih.2025.101023_bib20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.yhbeh.2016.12.009","article-title":"Effect of LPS treatment on tyrosine hydroxylase expression and Parkinson-like behaviors","volume":"89","author":"Girard-Joyal","year":"2017","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbih.2025.101023_bib21","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/j.bbi.2022.02.022","article-title":"The immunomodulatory effects of social isolation in mice are linked to temperature control","volume":"102","author":"Hamilton","year":"2022","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2025.101023_bib22","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1038\/s41386-018-0167-9","article-title":"Sex differences in the hypothalamic\u2013pituitary\u2013adrenal axis' response to stress: an important role for gonadal hormones","volume":"44","author":"Heck","year":"2019","journal-title":"Neuropsychopharmacology"},{"key":"10.1016\/j.bbih.2025.101023_bib23","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1159\/000126839","article-title":"Regulatory changes in neuroendocrine stress-integrative circuitry produced by a variable stress paradigm","volume":"61","author":"Herman","year":"1995","journal-title":"Neuroendocrinology"},{"key":"10.1016\/j.bbih.2025.101023_bib24","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/S0166-2236(96)10069-2","article-title":"Neurocircuitry of stress: central control of the hypothalamo\u2013pituitary\u2013adrenocortical axis","volume":"20","author":"Herman","year":"1997","journal-title":"Trends Neurosci."},{"key":"10.1016\/j.bbih.2025.101023_bib25","doi-asserted-by":"crossref","first-page":"1170","DOI":"10.1016\/j.psyneuen.2012.11.003","article-title":"Pubertal immune challenge blocks the ability of estradiol to enhance performance on cognitive tasks in adult female mice","volume":"38","author":"Ismail","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2025.101023_bib26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1016\/j.neuroscience.2012.09.047","article-title":"A pubertal immune challenge alters the antidepressant-like effects of chronic estradiol treatment in inbred and outbred adult female mice","volume":"249","author":"Ismail","year":"2013","journal-title":"Neuroscience"},{"key":"10.1016\/j.bbih.2025.101023_bib27","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.bbr.2016.11.006","article-title":"Puberty as a vulnerable period to the effects of immune challenges: focus on sex differences","volume":"320","author":"Kane","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2025.101023_bib28","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.112814","article-title":"Enriched environment effect on lipopolysaccharide-induced spatial learning, memory impairment and hippocampal inflammatory cytokine levels in male rats","volume":"394","author":"Keymoradzadeh","year":"2020","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2025.101023_bib29","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/S0149-7634(00)00027-0","article-title":"The effects of hormones on sex differences in infection: from genes to behavior","volume":"24","author":"Klein","year":"2000","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbih.2025.101023_bib30","doi-asserted-by":"crossref","first-page":"626","DOI":"10.1038\/nri.2016.90","article-title":"Sex differences in immune responses","volume":"16","author":"Klein","year":"2016","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2025.101023_bib31","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.psyneuen.2018.12.224","article-title":"Pubertal immune stress transiently alters spatial memory processes in adulthood","volume":"102","author":"Kolmogorova","year":"2019","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2025.101023_bib32","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol."},{"issue":"Suppl. 1","key":"10.1016\/j.bbih.2025.101023_bib33","first-page":"172","article-title":"The hypothalamic-pituitary-adrenal and the hypothalamic- pituitary-gonadal axes interplay","volume":"3","author":"Mastorakos","year":"2006","journal-title":"Pediatr. Endocrinol. Rev."},{"key":"10.1016\/j.bbih.2025.101023_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.yhbeh.2020.104845","article-title":"Adolescent social instability stress leads to immediate and lasting sex-specific changes in the neuroendocrine-immune-gut axis in rats","volume":"126","author":"McCormick","year":"2020","journal-title":"Horm. Behav."},{"key":"10.1016\/j.bbih.2025.101023_bib35","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/j.psyneuen.2012.10.003","article-title":"Environmental enrichment influences brain cytokine variations elicited by social defeat in mice","volume":"38","author":"McQuaid","year":"2013","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2025.101023_bib36","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbr.2016.09.004","article-title":"Corticosterone and immune cytokine characterization following environmental manipulation in female WKY rats","volume":"316","author":"Mileva","year":"2017","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2025.101023_bib37","first-page":"247","article-title":"SEPP: SAT\u00e9-enabled phylogenetic placement","author":"Mirarab","year":"2012","journal-title":"Pac. Symp. Biocomput. Pac. Symp. Biocomput."},{"key":"10.1016\/j.bbih.2025.101023_bib38","doi-asserted-by":"crossref","first-page":"4888","DOI":"10.1210\/en.2016-1317","article-title":"Neonatal androgen exposure causes persistent gut microbiota dysbiosis related to metabolic disease in adult female rats","volume":"157","author":"Moreno-Indias","year":"2016","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbih.2025.101023_bib39","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2020.113001","article-title":"Chronic sleep disruption induces depression-like behavior in adolescent male and female mice and sensitization of the hypothalamic-pituitary-adrenal axis in adolescent female mice","volume":"399","author":"Murack","year":"2021","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2025.101023_bib40","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainres.2023.148283","article-title":"Environmental enrichment alters LPS-induced changes in BDNF and PSD-95 expressions during puberty","volume":"1806","author":"Murack","year":"2023","journal-title":"Brain Res."},{"key":"10.1016\/j.bbih.2025.101023_bib41","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bbi.2023.03.009","article-title":"Effects of pair-housing pubertal and adult male and female mice on LPS-induced age-dependent immune responses: a potential role for the gut microbiota","volume":"110","author":"Murray","year":"2023","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2025.101023_bib42","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1016\/j.bbi.2019.06.016","article-title":"Probiotic consumption during puberty mitigates LPS-induced immune responses and protects against stress-induced depression- and anxiety-like behaviors in adulthood in a sex-specific manner","volume":"81","author":"Murray","year":"2019","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2025.101023_bib43","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104481","article-title":"Pubertal probiotic blocks LPS-induced anxiety and the associated neurochemical and microbial outcomes, in a sex dependent manner","volume":"112","author":"Murray","year":"2020","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2025.101023_bib44","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1385\/IR:23:2-3:281","article-title":"Effects of androgens on T and B lymphocyte development","volume":"23","author":"Olsen","year":"2001","journal-title":"Immunol. Res."},{"key":"10.1016\/j.bbih.2025.101023_bib45","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1203\/01.pdr.0000250014.92242.f3","article-title":"Effects of butyrate on intestinal barrier function in a caco-2 cell monolayer model of intestinal barrier","volume":"61","author":"Peng","year":"2007","journal-title":"Pediatr. Res."},{"key":"10.1016\/j.bbih.2025.101023_bib46","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1210\/endo-65-3-369","article-title":"Organizing action of prenatally administered testosterone propionate on the tissues mediating mating behavior in the female Guinea pig","volume":"65","author":"Phoenix","year":"1959","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbih.2025.101023_bib47","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s40750-016-0050-z","article-title":"To remove or not to remove: the impact of outlier handling on significance testing in testosterone data","volume":"3","author":"Pollet","year":"2017","journal-title":"Adapt. Hum. Behav. Physiol."},{"key":"10.1016\/j.bbih.2025.101023_bib48","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1677\/joe.0.1150459","article-title":"Relative occupation of type-I and type-II corticosteroid receptors in rat brain following stress and dexamethasone treatment: functional implications","volume":"115","author":"Reul","year":"1987","journal-title":"J. Endocrinol."},{"key":"10.1016\/j.bbih.2025.101023_bib49","doi-asserted-by":"crossref","first-page":"14","DOI":"10.3390\/microorganisms7010014","article-title":"What is the healthy gut microbiota composition? A changing ecosystem across age, environment, diet, and diseases","volume":"7","author":"Rinninella","year":"2019","journal-title":"Microorganisms"},{"key":"10.1016\/j.bbih.2025.101023_bib50","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1038\/nri2565","article-title":"Regulation of innate immune responses in the brain","volume":"9","author":"Rivest","year":"2009","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2025.101023_bib51","doi-asserted-by":"crossref","first-page":"761","DOI":"10.1016\/S0306-4530(01)00064-6","article-title":"How circulating cytokines trigger the neural circuits that control the hypothalamic\u2013pituitary\u2013adrenal axis","volume":"26","author":"Rivest","year":"2001","journal-title":"Psychoneuroendocrinology"},{"issue":"Copenh","key":"10.1016\/j.bbih.2025.101023_bib52","first-page":"298","article-title":"Effect of desoxycorticosterone on inflammation after local administration","volume":"25","author":"Robert","year":"1957","journal-title":"Acta Endocrinol."},{"key":"10.1016\/j.bbih.2025.101023_bib53","doi-asserted-by":"crossref","first-page":"1910","DOI":"10.1016\/j.celrep.2019.04.023","article-title":"Comparison of co-housing and littermate methods for microbiota standardization in mouse models","volume":"27","author":"Robertson","year":"2019","journal-title":"Cell Rep"},{"key":"10.1016\/j.bbih.2025.101023_bib55","doi-asserted-by":"crossref","first-page":"1664","DOI":"10.1210\/en.2005-1432","article-title":"Stress history and pubertal development interact to shape hypothalamic-pituitary-adrenal axis plasticity","volume":"147","author":"Romeo","year":"2006","journal-title":"Endocrinology"},{"key":"10.1016\/j.bbih.2025.101023_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2022.110783","article-title":"Reduced housing density improves statistical power of murine gut microbiota studies","volume":"39","author":"Russell","year":"2022","journal-title":"Cell Rep."},{"key":"10.1016\/j.bbih.2025.101023_bib57","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.physbeh.2014.02.048","article-title":"Increase of glucocorticoid receptor expression after environmental enrichment: relations to spatial memory, exploration and anxiety-related behaviors","volume":"129","author":"Sampedro-Piquero","year":"2014","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbih.2025.101023_bib58","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1038\/nmeth.2019","article-title":"Fiji: an open-source platform for biological-image analysis","volume":"9","author":"Schindelin","year":"2012","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbih.2025.101023_bib59","doi-asserted-by":"crossref","first-page":"1383","DOI":"10.1136\/bmj.1.4667.1383","article-title":"Stress and the general adaptation syndrome","volume":"1","author":"Selye","year":"1950","journal-title":"Br. Med. J."},{"key":"10.1016\/j.bbih.2025.101023_bib60","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1097\/00006842-195005000-00003","article-title":"Adaptive reaction to stress","volume":"12","author":"Selye","year":"1950","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbih.2025.101023_bib61","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1016\/j.imlet.2019.03.005","article-title":"The adaptive immune and stress responses of adult female CD1 mice following exposure to a viral mimetic","volume":"208","author":"Sharma","year":"2019","journal-title":"Immunol. Lett."},{"key":"10.1016\/j.bbih.2025.101023_bib63","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1016\/j.ijdevneu.2018.07.012","article-title":"Sex differences in the peripheral and central immune responses following lipopolysaccharide treatment in pubertal and adult CD-1 mice","volume":"71","author":"Sharma","year":"2018","journal-title":"Int. J. Dev. Neurosci."},{"key":"10.1016\/j.bbih.2025.101023_bib79","doi-asserted-by":"crossref","first-page":"2131","DOI":"10.4049\/jimmunol.1801351","article-title":"Programming effects of pubertal lipopolysaccharide treatment in male and female CD-1 mice","volume":"202","author":"Sharma","year":"2019","journal-title":"J. Immunol."},{"key":"10.1016\/j.bbih.2025.101023_bib64","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2020.604000","article-title":"Sexual dimorphism in innate immunity: the role of sex hormones and epigenetics","volume":"11","author":"Shepherd","year":"2021","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2025.101023_bib65","doi-asserted-by":"crossref","first-page":"1040","DOI":"10.1038\/nn1326","article-title":"The neural basis of puberty and adolescence","volume":"7","author":"Sisk","year":"2004","journal-title":"Nat. Neurosci."},{"key":"10.1016\/j.bbih.2025.101023_bib66","doi-asserted-by":"crossref","DOI":"10.1016\/j.brainresbull.2023.110701","article-title":"The sex-dependent and enduring impact of pubertal stress on health and disease","volume":"200","author":"Smith","year":"2023","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbih.2025.101023_bib67","article-title":"Environmental enrichment cage for laboratory mice: a downloadable alternative","volume":"4","author":"Smith","year":"2024","journal-title":"Curr. Protoc."},{"key":"10.1016\/j.bbih.2025.101023_bib68","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.brainresbull.2021.09.017","article-title":"Pubertal probiotics mitigate lipopolysaccharide-induced programming of the hypothalamic-pituitary-adrenal axis in male mice only","volume":"177","author":"Smith","year":"2021","journal-title":"Brain Res. Bull."},{"key":"10.1016\/j.bbih.2025.101023_bib80","doi-asserted-by":"crossref","first-page":"114324","DOI":"10.1016\/j.ygcen.2023.114324","article-title":"Enduring sex-dependent effects of lipopolysaccharide treatment on the hypothalamic-pituitary-gonadal axis in mice","volume":"340","author":"Smith","year":"2023","journal-title":"Gen. Comp. Endocrinol."},{"key":"10.1016\/j.bbih.2025.101023_bib71","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1210\/er.2007-0001","article-title":"The complex role of estrogens in inflammation","volume":"28","author":"Straub","year":"2007","journal-title":"Endocr. Rev."},{"key":"10.1016\/j.bbih.2025.101023_bib72","doi-asserted-by":"crossref","DOI":"10.1080\/21688370.2017.1373208","article-title":"Intestinal barrier and gut microbiota: shaping our immune responses throughout life","volume":"5","author":"Takiishi","year":"2017","journal-title":"Tissue Barriers"},{"key":"10.1016\/j.bbih.2025.101023_bib73","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0149-7634(03)00007-1","article-title":"The neurobiological consequences of early stress and childhood maltreatment","volume":"27","author":"Teicher","year":"2003","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbih.2025.101023_bib74","doi-asserted-by":"crossref","DOI":"10.1016\/j.heliyon.2023.e15417","article-title":"The influence of antibiotic treatment on the behavior and gut microbiome of adult rats neonatally insulted with lipopolysaccharide","volume":"9","author":"Tejkalov\u00e1","year":"2023","journal-title":"Heliyon"},{"key":"10.1016\/j.bbih.2025.101023_bib75","doi-asserted-by":"crossref","first-page":"462","DOI":"10.4103\/1673-5374.245470","article-title":"An enriched environment promotes synaptic plasticity and cognitive recovery after permanent middle cerebral artery occlusion in mice","volume":"14","author":"Wang","year":"2019","journal-title":"Neural Regen. Res."},{"key":"10.1016\/j.bbih.2025.101023_bib76","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.immuni.2013.08.013","article-title":"Gender bias in autoimmunity is influenced by microbiota","volume":"39","author":"Yurkovetskiy","year":"2013","journal-title":"Immunity (Camb., Mass.)"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266635462500081X?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S266635462500081X?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:39:20Z","timestamp":1762637960000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S266635462500081X"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,7]]},"references-count":76,"alternative-id":["S266635462500081X"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2025.101023","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2025,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Modulating effects of environmental enrichment on stress-induced changes in the gut microbiome","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2025.101023","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101023"}}