{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:42:08Z","timestamp":1762638128695,"version":"build-2065373602"},"reference-count":43,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2025,11,1]],"date-time":"2025-11-01T00:00:00Z","timestamp":1761955200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,10,12]],"date-time":"2025-10-12T00:00:00Z","timestamp":1760227200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2025,11]]},"DOI":"10.1016\/j.bbih.2025.101121","type":"journal-article","created":{"date-parts":[[2025,10,15]],"date-time":"2025-10-15T19:30:08Z","timestamp":1760556608000},"page":"101121","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Combined effects of calorie restriction and chronic stress on systemic inflammation and gut microbiota in rats exposed to Leptospira interrogans lipopolysaccharide"],"prefix":"10.1016","volume":"49","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0860-4445","authenticated-orcid":false,"given":"Pavlo","family":"Petakh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yaroslav","family":"Stravskyy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Iryna","family":"Halabitska","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alina","family":"Pavliuk","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Oleksandr","family":"Kamyshnyi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2025.101121_bib1","doi-asserted-by":"crossref","DOI":"10.3390\/jcm13216394","article-title":"Immunology of stress: a review article","volume":"13","author":"Alotiby","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbih.2025.101121_bib2","doi-asserted-by":"crossref","DOI":"10.1080\/19490976.2024.2327409","article-title":"Stress in the microbiome-immune crosstalk","volume":"16","author":"Beurel","year":"2024","journal-title":"Gut Microbes"},{"key":"10.1016\/j.bbih.2025.101121_bib3","doi-asserted-by":"crossref","first-page":"1085","DOI":"10.1016\/0031-9384(95)02043-8","article-title":"Effects of housing on male and female rats: crowding stresses males but calms females","volume":"58","author":"Brown","year":"1995","journal-title":"Physiol. Behav."},{"key":"10.1016\/j.bbih.2025.101121_bib4","doi-asserted-by":"crossref","first-page":"38703","DOI":"10.1074\/jbc.M111.275370","article-title":"Glucocorticoids sensitize the innate immune system through regulation of the NLRP3 inflammasome","volume":"286","author":"Busillo","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbih.2025.101121_bib5","doi-asserted-by":"crossref","DOI":"10.1128\/mbio.01906-24","article-title":"Gut microbiota-derived butyrate improved acute leptospirosis in hamster via promoting macrophage ROS mediated by HDAC3 inhibition","volume":"15","author":"Chen","year":"2024","journal-title":"mBio"},{"key":"10.1016\/j.bbih.2025.101121_bib6","doi-asserted-by":"crossref","first-page":"81","DOI":"10.30802\/AALAS-JAALAS-23-000007","article-title":"Histological alterations in the internal organs of Wistar Han rats (Rattus norvegicus) euthanized by five different methods","volume":"63","author":"Costa","year":"2024","journal-title":"J. American Association Laboratory Animal Sci."},{"key":"10.1016\/j.bbih.2025.101121_bib7","first-page":"6546","article-title":"The less we eat, the longer We Live: can caloric restriction help us become Centenarians?","volume":"23","author":"Dakic","year":"2022"},{"key":"10.1016\/j.bbih.2025.101121_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.arr.2020.101038","article-title":"Calorie restriction for enhanced longevity: the role of novel dietary strategies in the present obesogenic environment","volume":"64","author":"Dorling","year":"2020","journal-title":"Ageing Res. Rev."},{"key":"10.1016\/j.bbih.2025.101121_bib9","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1016\/j.cmet.2018.08.005","article-title":"Functional gut microbiota remodeling contributes to the caloric restriction-induced metabolic improvements","volume":"28","author":"Fabbiano","year":"2018","journal-title":"Cell Metab."},{"key":"10.1016\/j.bbih.2025.101121_bib10","doi-asserted-by":"crossref","first-page":"688","DOI":"10.1093\/gerona\/60.6.688","article-title":"Caloric restriction decreases survival of aged mice in response to primary influenza infection","volume":"60","author":"Gardner","year":"2005","journal-title":"J. Gerontol.Series A, Biol. Sci.Med.Sci."},{"key":"10.1016\/j.bbih.2025.101121_bib11","doi-asserted-by":"crossref","DOI":"10.1063\/5.0055784","article-title":"A qualitative mathematical model of the immune response under the effect of stress","volume":"31","author":"Gonzalez Herrero","year":"2021","journal-title":"Chaos"},{"issue":"162","key":"10.1016\/j.bbih.2025.101121_bib12","doi-asserted-by":"crossref","first-page":"3749","DOI":"10.4049\/jimmunol.162.7.3749","article-title":"Cutting edge: Toll-like receptor 4 (TLR4)-deficient mice are hyporesponsive to lipopolysaccharide: evidence for TLR4 as the Lps gene product","author":"Hoshino","year":"1999","journal-title":"J. Immunol.(Baltimore, Md."},{"key":"10.1016\/j.bbih.2025.101121_bib13","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1615\/CritRevImmunol.v32.i1.30","article-title":"Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease","volume":"32","author":"Iyer","year":"2012","journal-title":"Crit. Rev. Immunol."},{"key":"10.1016\/j.bbih.2025.101121_bib14","doi-asserted-by":"crossref","first-page":"1558","DOI":"10.1093\/advances\/nmaa179","article-title":"Calorie restriction as a new treatment of inflammatory diseases","volume":"12","author":"K\u00f6kten","year":"2021","journal-title":"Adv. Nutr."},{"key":"10.1016\/j.bbih.2025.101121_bib15","first-page":"1","article-title":"The role of leptospiremia and specific immune response in severe leptospirosis","volume":"11","author":"Limothai","year":"2021","journal-title":"J. Scientific Rep."},{"key":"10.1016\/j.bbih.2025.101121_bib16","doi-asserted-by":"crossref","first-page":"402","DOI":"10.1006\/meth.2001.1262","article-title":"Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method","volume":"25","author":"Livak","year":"2001","journal-title":"Methods"},{"key":"10.1016\/j.bbih.2025.101121_bib17","doi-asserted-by":"crossref","first-page":"378","DOI":"10.1038\/s41598-019-57252-7","article-title":"Sodium pentobarbital dosages for exsanguination affect biochemical, molecular and histological measurements in rats","volume":"10","author":"Mohamed","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2025.101121_bib18","doi-asserted-by":"crossref","first-page":"61","DOI":"10.46847\/ujmm.2023.1(4)-061","article-title":"Epidemiologic features of leptospirosis among the population of Ukraine and in military collectives","volume":"4","author":"Ogorodniychuk","year":"2023","journal-title":"Ukrainian J. Military Med."},{"key":"10.1016\/j.bbih.2025.101121_bib19","doi-asserted-by":"crossref","DOI":"10.3390\/biom12121830","article-title":"Weil's disease-immunopathogenesis, multiple organ failure, and potential role of gut microbiota","volume":"12","author":"Petakh","year":"2022","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbih.2025.101121_bib20","doi-asserted-by":"crossref","DOI":"10.3389\/fmicb.2024.1345684","article-title":"Exploring the complex interplay: gut microbiome, stress, and leptospirosis","volume":"15","author":"Petakh","year":"2024","journal-title":"Front. Microbiol."},{"key":"10.1016\/j.bbih.2025.101121_bib21","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1349883","article-title":"Exploring the interplay between posttraumatic stress disorder, gut microbiota, and inflammatory biomarkers: a comprehensive meta-analysis","volume":"15","author":"Petakh","year":"2024","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2025.101121_bib22","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pntd.0012927","article-title":"Prevalence of leptospirosis among soldiers: a systematic review","volume":"19","author":"Petakh","year":"2025","journal-title":"PLoS Neglected Trop. Dis."},{"key":"10.1016\/j.bbih.2025.101121_bib23","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-020-76219-7","article-title":"Caloric restriction modulates the monoaminergic system and metabolic hormones in aged rats","volume":"10","author":"Portero-Tresserra","year":"2020","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2025.101121_bib24","doi-asserted-by":"crossref","first-page":"996","DOI":"10.1111\/1574-6976.12075","article-title":"The first 1000 cultured species of the human gastrointestinal microbiota","volume":"38","author":"Rajili\u0107-Stojanovi\u0107","year":"2014","journal-title":"FEMS Microbiol. Rev."},{"key":"10.1016\/j.bbih.2025.101121_bib25","doi-asserted-by":"crossref","DOI":"10.1016\/j.micpath.2021.104761","article-title":"Enterococcus Faecalis activates NLRP3 inflammasomes leading to increased interleukin-1 beta secretion and pyroptosis of THP-1 macrophages","volume":"154","author":"Ran","year":"2021","journal-title":"Microb. Pathog."},{"key":"10.1016\/j.bbih.2025.101121_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.pharmr.2025.100063","article-title":"Immunomodulatory effects of calorie restriction and its mimetics: a new potential therapeutic approach for autoimmune diseases","volume":"77","author":"Sen","year":"2025","journal-title":"Pharmacol. Rev."},{"key":"10.1016\/j.bbih.2025.101121_bib27","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1186\/s12879-020-04986-9","article-title":"Cytokine response in human leptospirosis with different clinical outcomes: a systematic review","volume":"20","author":"Senavirathna","year":"2020","journal-title":"BMC Infect. Dis."},{"key":"10.1016\/j.bbih.2025.101121_bib28","doi-asserted-by":"crossref","first-page":"671","DOI":"10.1126\/science.abg7292","article-title":"Caloric restriction in humans reveals immunometabolic regulators of health span","volume":"375","author":"Spadaro","year":"2022","journal-title":"Science"},{"key":"10.1016\/j.bbih.2025.101121_bib29","series-title":"Assessment of Serum Macrophage Migration Inhibitory Factor (MIF) as an Early Diagnostic Marker of Leptospirosis","volume":"vol. 11","author":"Sumaiya","year":"2022"},{"key":"10.1016\/j.bbih.2025.101121_bib30","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1128\/CDLI.8.5.1003-1011.2001","article-title":"Effects of calorie restriction on polymicrobial peritonitis induced by cecum ligation and puncture in young C57BL\/6 mice","volume":"8","author":"Sun","year":"2001","journal-title":"Clin. Diagn. Lab. Immunol."},{"key":"10.1016\/j.bbih.2025.101121_bib31","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0294236","article-title":"SRplot: a free online platform for data visualization and graphing","volume":"18","author":"Tang","year":"2023","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2025.101121_bib32","doi-asserted-by":"crossref","first-page":"455","DOI":"10.1016\/j.chom.2017.03.002","article-title":"Age-associated microbial dysbiosis promotes intestinal permeability, systemic inflammation, and macrophage dysfunction","volume":"21","author":"Thevaranjan","year":"2017","journal-title":"Cell Host Microbe"},{"key":"10.1016\/j.bbih.2025.101121_bib33","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1186\/1475-2891-10-107","article-title":"Impact of caloric and dietary restriction regimens on markers of health and longevity in humans and animals: a summary of available findings","volume":"10","author":"Trepanowski","year":"2011","journal-title":"Nutr. J."},{"key":"10.1016\/j.bbih.2025.101121_bib34","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.jnutbio.2006.03.008","article-title":"Caloric restriction inhibits up-regulation of inflammatory cytokines and TNF-alpha, and activates IL-10 and haptoglobin in the plasma of streptozotocin-induced diabetic rats","volume":"18","author":"Ugochukwu","year":"2007","journal-title":"J. Nutr. Biochem."},{"year":"2020","series-title":"AVMA Guidelines for the Euthanasia of Animals","author":"Underwood","key":"10.1016\/j.bbih.2025.101121_bib35"},{"key":"10.1016\/j.bbih.2025.101121_bib36","doi-asserted-by":"crossref","first-page":"2215","DOI":"10.1007\/s11357-013-9518-y","article-title":"Interleukin-8 and interleukin-10, brain volume and microstructure, and the influence of calorie restriction in old rhesus macaques","volume":"35","author":"Willette","year":"2013","journal-title":"Age"},{"key":"10.1016\/j.bbih.2025.101121_bib37","doi-asserted-by":"crossref","first-page":"764","DOI":"10.1038\/s41396-021-01122-6","article-title":"Gut microbiota involved in leptospiral infections","volume":"16","author":"Xie","year":"2022","journal-title":"J. ISME"},{"key":"10.1016\/j.bbih.2025.101121_bib38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0036890","article-title":"Estrogen modulates NF\u03baB signaling by enhancing I\u03baB\u03b1 levels and blocking p65 binding at the promoters of inflammatory genes via estrogen receptor-\u03b2","volume":"7","author":"Xing","year":"2012","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2025.101121_bib39","doi-asserted-by":"crossref","first-page":"21041","DOI":"10.1074\/jbc.M111.222091","article-title":"Structure and immunological characterization of the capsular polysaccharide of a pyrogenic liver abscess caused by Klebsiella pneumoniae: activation of macrophages through toll-like receptor 4","volume":"286","author":"Yang","year":"2011","journal-title":"J. Biol. Chem."},{"key":"10.1016\/j.bbih.2025.101121_bib40","doi-asserted-by":"crossref","first-page":"294","DOI":"10.3390\/biom11020294","article-title":"Psychosocial crowding stress-induced changes in synaptic transmission and glutamate receptor expression in the rat frontal cortex","volume":"11","author":"Zelek-Molik","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbih.2025.101121_bib41","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1681\/ASN.2007090982","article-title":"TLR4 signaling mediates inflammation and tissue injury in nephrotoxicity","volume":"19","author":"Zhang","year":"2008","journal-title":"J. Am. Soc. Nephrol. : JASN (J. Am. Soc. Nephrol.)"},{"key":"10.1016\/j.bbih.2025.101121_bib42","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/s11684-018-0670-8","article-title":"Calorie restriction and its impact on gut microbial composition and global metabolism","volume":"12","author":"Zheng","year":"2018","journal-title":"Front. Med."},{"key":"10.1016\/j.bbih.2025.101121_bib43","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1089\/vbz.2023.0007","article-title":"A single clinical case of leptospirosis in a 70-Year-Old man during the military conflict in Ukraine","volume":"23","author":"Zubach","year":"2023","journal-title":"Vector Borne Zoonotic Dis."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354625001796?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354625001796?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2025,11,8]],"date-time":"2025-11-08T21:38:49Z","timestamp":1762637929000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354625001796"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,11]]},"references-count":43,"alternative-id":["S2666354625001796"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2025.101121","relation":{},"ISSN":["2666-3546"],"issn-type":[{"type":"print","value":"2666-3546"}],"subject":[],"published":{"date-parts":[[2025,11]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Combined effects of calorie restriction and chronic stress on systemic inflammation and gut microbiota in rats exposed to Leptospira interrogans lipopolysaccharide","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2025.101121","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101121"}}