{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T03:35:33Z","timestamp":1773891333617,"version":"3.50.1"},"reference-count":53,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,2,1]],"date-time":"2026-02-01T00:00:00Z","timestamp":1769904000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2025,11,30]],"date-time":"2025-11-30T00:00:00Z","timestamp":1764460800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2026,2]]},"DOI":"10.1016\/j.bbih.2025.101154","type":"journal-article","created":{"date-parts":[[2025,12,6]],"date-time":"2025-12-06T00:43:24Z","timestamp":1764981804000},"page":"101154","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Accelerated Theta Burst Stimulation Transcranial Magnetic Stimulation (iTBS-TMS) Pururauka program for severe depressive episode and suicide ideation"],"prefix":"10.1016","volume":"51","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5096-6941","authenticated-orcid":false,"given":"Hesed","family":"Virto-Farfan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlos","family":"Virto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7652-4789","authenticated-orcid":false,"given":"Gustavo E.","family":"Tafet","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"78","reference":[{"issue":"2","key":"10.1016\/j.bbih.2025.101154_bib1","doi-asserted-by":"crossref","DOI":"10.1002\/brb3.70329","article-title":"Effects of repetitive transcranial magnetic stimulation on tumor necrosis factor alpha in neuropsychological disorders: a systematic review and meta-analysis","volume":"15","author":"Asadizeidabadi","year":"2025","journal-title":"Brain Behav"},{"issue":"1","key":"10.1016\/j.bbih.2025.101154_bib2","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1038\/s41398-023-02537-9","article-title":"Network effects of stanford Neuromodulation Therapy (SNT) in treatment-resistant major depressive disorder: a randomized, controlled trial","volume":"13","author":"Batail","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2025.101154_bib3","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-20274-9","article-title":"Reduced subgenual cingulate-dorsolateral prefrontal connectivity as an electrophysiological marker for depression","volume":"12","author":"Benschop","year":"2022","journal-title":"Sci. Rep."},{"issue":"2","key":"10.1016\/j.bbih.2025.101154_bib4","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1017\/S0033291713000512","article-title":"Response, remission and drop-out rates following high-frequency repetitive transcranial magnetic stimulation (rTMS) for treating major depression: a systematic review and meta-analysis of randomized, double-blind and sham-controlled trials","volume":"44","author":"Berlim","year":"2014","journal-title":"Psychol. Med."},{"issue":"10131","key":"10.1016\/j.bbih.2025.101154_bib5","doi-asserted-by":"crossref","first-page":"1683","DOI":"10.1016\/S0140-6736(18)30295-2","article-title":"Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial","volume":"391","author":"Blumberger","year":"2018","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2025.101154_bib6","series-title":"Suicide Data and Statistics [Internet]. Suicide Prevention","year":"2024"},{"key":"10.1016\/j.bbih.2025.101154_bib7","article-title":"Efficacy and tolerability of repetitive transcranial magnetic stimulation on suicidal ideation: a systemic review and meta-analysis","volume":"13","author":"Chen","year":"2022","journal-title":"Front. Psychiatr."},{"issue":"2","key":"10.1016\/j.bbih.2025.101154_bib8","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1002\/wps.20128","article-title":"Risks of all-cause and suicide mortality in mental disorders: a meta-review","volume":"13","author":"Chesney","year":"2014","journal-title":"World Psychiatry"},{"issue":"2","key":"10.1016\/j.bbih.2025.101154_bib9","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1176\/appi.ajp.2021.20101429","article-title":"Stanford Neuromodulation Therapy (SNT): a double-blind randomized controlled trial","volume":"179","author":"Cole","year":"2022","journal-title":"Am. J. Psychiatr."},{"issue":"4","key":"10.1016\/j.bbih.2025.101154_bib10","doi-asserted-by":"crossref","first-page":"697","DOI":"10.3390\/jpm13040697","article-title":"Investigating the role of maintenance TMS protocols for major depression: systematic review and future perspectives for personalized interventions","volume":"13","author":"d'Andrea","year":"2023","journal-title":"J. Personalized Med."},{"issue":"1","key":"10.1016\/j.bbih.2025.101154_bib11","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1017\/S1461145708008973","article-title":"Reduced amygdala-prefrontal coupling in major depression: association with MAOA genotype and illness severity","volume":"12","author":"Dannlowski","year":"2009","journal-title":"Int. J. Neuropsychopharmacol."},{"key":"10.1016\/j.bbih.2025.101154_bib12","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.cpr.2014.10.006","article-title":"Neurostimulation as an intervention for treatment resistant depression: from research on mechanisms towards targeted neurocognitive strategies","volume":"41","author":"De Raedt","year":"2015","journal-title":"Clin. Psychol. Rev."},{"issue":"17","key":"10.1016\/j.bbih.2025.101154_bib13","doi-asserted-by":"crossref","first-page":"3042","DOI":"10.1523\/JNEUROSCI.2226-22.2023","article-title":"Microglial cytokines mediate plasticity induced by 10 Hz repetitive magnetic stimulation","volume":"43","author":"Eichler","year":"2023","journal-title":"J. Neurosci."},{"issue":"3","key":"10.1016\/j.bbih.2025.101154_bib14","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1056\/NEJMra1902944","article-title":"Suicide","volume":"382","author":"Fazel","year":"2020","journal-title":"N. Engl. J. Med."},{"issue":"9905","key":"10.1016\/j.bbih.2025.101154_bib15","doi-asserted-by":"crossref","first-page":"1646","DOI":"10.1016\/S0140-6736(13)60899-5","article-title":"Premature mortality in epilepsy and the role of psychiatric comorbidity: a total population study","volume":"382","author":"Fazel","year":"2013","journal-title":"Lancet"},{"issue":"3","key":"10.1016\/j.bbih.2025.101154_bib16","doi-asserted-by":"crossref","first-page":"326","DOI":"10.1001\/jamapsychiatry.2013.3935","article-title":"Suicide, fatal injuries, and other causes of premature mortality in patients with traumatic brain injury: a 41-year Swedish population study","volume":"71","author":"Fazel","year":"2014","journal-title":"JAMA Psychiatry"},{"issue":"5","key":"10.1016\/j.bbih.2025.101154_bib18","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1001\/archgenpsychiatry.2010.46","article-title":"Daily left prefrontal transcranial magnetic stimulation therapy for major depressive disorder: a sham-controlled randomized trial","volume":"67","author":"George","year":"2010","journal-title":"Arch. Gen. Psychiatry"},{"issue":"6","key":"10.1016\/j.bbih.2025.101154_bib19","doi-asserted-by":"crossref","first-page":"1753","DOI":"10.1016\/j.brs.2023.11.010","article-title":"EEG synchronized left prefrontal transcranial magnetic stimulation (TMS) for treatment resistant depression is feasible and produces an entrainment dependent clinical response: a randomized controlled double blind clinical trial","volume":"16","author":"George","year":"2023","journal-title":"Brain Stimul."},{"issue":"4","key":"10.1016\/j.bbih.2025.101154_bib20","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1001\/jamapsychiatry.2017.4602","article-title":"Epidemiology of adult DSM-5 major depressive disorder and ts specifiers in the United States","volume":"75","author":"Hasin","year":"2018","journal-title":"JAMA Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2025.101154_bib21","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/s12868-022-00735-7","article-title":"High-frequency repetitive transcranial magnetic stimulation (rTMS) protects against ischemic stroke by inhibiting M1 microglia polarization through let-7b-5p\/HMGA2\/NF-\u03baB signaling pathway","volume":"23","author":"Hong","year":"2022","journal-title":"BMC Neurosci."},{"issue":"2","key":"10.1016\/j.bbih.2025.101154_bib22","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/j.neuron.2004.12.033","article-title":"Theta burst stimulation of the human motor cortex","volume":"45","author":"Huang","year":"2005","journal-title":"Neuron"},{"issue":"3","key":"10.1016\/j.bbih.2025.101154_bib23","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.neuron.2020.02.003","article-title":"Closed-loop theta stimulation in the orbitofrontal cortex prevents reward-based learning","volume":"106","author":"Knudsen","year":"2020","journal-title":"Neuron"},{"issue":"10","key":"10.1016\/j.bbih.2025.101154_bib24","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1016\/j.jagp.2020.07.007","article-title":"Accelerated intermittent theta burst stimulation in late-life depression: a possible option for older depressed adults in need of ECT during the COVID-19 pandemic","volume":"28","author":"Konstantinou","year":"2020","journal-title":"Am. J. Geriatr. Psychiatr."},{"issue":"11","key":"10.1016\/j.bbih.2025.101154_bib25","doi-asserted-by":"crossref","first-page":"2150","DOI":"10.1016\/j.clinph.2014.05.021","article-title":"Evidence-based guidelines on the therapeutic use of repetitive transcranial magnetic stimulation (rTMS)","volume":"125","author":"Lefaucheur","year":"2014","journal-title":"Clin. Neurophysiol."},{"issue":"3","key":"10.1016\/j.bbih.2025.101154_bib26","doi-asserted-by":"crossref","first-page":"359","DOI":"10.3390\/biom11030359","article-title":"Monitoring and modulating inflammation-associated alterations in synaptic plasticity: role of brain stimulation and the blood-brain interface","volume":"11","author":"Lenz","year":"2021","journal-title":"Biomolecules"},{"key":"10.1016\/j.bbih.2025.101154_bib28","doi-asserted-by":"crossref","first-page":"364","DOI":"10.1016\/j.jad.2022.05.107","article-title":"Cortical excitatory and inhibitory correlates of the fronto-limbic circuit in major depression and differential effects of left frontal brain stimulation in a randomized sham-controlled trial","volume":"311","author":"Li","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"7","key":"10.1016\/j.bbih.2025.101154_bib29","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.biopsych.2014.01.023","article-title":"Default mode network mechanisms of transcranial magnetic stimulation in depression","volume":"76","author":"Liston","year":"2014","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2025.101154_bib30","first-page":"28","article-title":"Effects of transcranial magnetic stimulation combined with sertraline on cognitive level, inflammatory response and neurological function in depressive disorder patients with non-suicidal self-injury behavior","volume":"52","author":"Liu","year":"2024","journal-title":"Actas Esp. Psiquiatr."},{"issue":"5","key":"10.1016\/j.bbih.2025.101154_bib31","doi-asserted-by":"crossref","first-page":"800","DOI":"10.1016\/S1388-2457(99)00323-5","article-title":"Modulation of corticospinal excitability by repetitive transcranial magnetic stimulation","volume":"111","author":"Maeda","year":"2000","journal-title":"Clin. Neurophysiol."},{"issue":"12","key":"10.1016\/j.bbih.2025.101154_bib32","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1002\/da.20540","article-title":"Treatment-resistant depression: recent developments and future directions","volume":"25","author":"Mathew","year":"2008","journal-title":"Depress. Anxiety"},{"issue":"1","key":"10.1016\/j.bbih.2025.101154_bib33","doi-asserted-by":"crossref","DOI":"10.4088\/JCP.16cs10905","article-title":"Consensus recommendations for the clinical application of repetitive transcranial magnetic stimulation (rTMS) in the treatment of depression","volume":"79","author":"McClintock","year":"2018","journal-title":"J. Clin. Psychiatry"},{"key":"10.1016\/j.bbih.2025.101154_bib34","doi-asserted-by":"crossref","DOI":"10.1016\/j.pmip.2020.100066","article-title":"Individualized theta-burst stimulation modulates hippocampal activity and connectivity in patients with major depressive disorder","author":"Mielacher","year":"2020","journal-title":"Personalized Medicine in Psychiatry"},{"issue":"7509","key":"10.1016\/j.bbih.2025.101154_bib35","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1136\/bmj.331.7509.155","article-title":"Efficacy of antidepressants in adults","volume":"331","author":"Moncrieff","year":"2005","journal-title":"BMJ"},{"key":"10.1016\/j.bbih.2025.101154_bib36","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.neubiorev.2015.07.014","article-title":"Resting-state functional connectivity in major depressive disorder: a review","volume":"56","author":"Mulders","year":"2015","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"9","key":"10.1016\/j.bbih.2025.101154_bib37","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232863","article-title":"Repetitive transcranial magnetic stimulation activates glial cells and inhibits neurogenesis after pneumococcal meningitis","volume":"15","author":"Muri","year":"2020","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2025.101154_bib38","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.65","article-title":"Major depressive disorder","volume":"2","author":"Otte","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"issue":"8","key":"10.1016\/j.bbih.2025.101154_bib39","doi-asserted-by":"crossref","first-page":"2287","DOI":"10.1038\/s41380-024-02468-x","article-title":"Comparative effectiveness research trial for antidepressant incomplete and non-responders with treatment resistant depression (ASCERTAIN-TRD) a randomized clinical trial","volume":"29","author":"Papakostas","year":"2024","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2025.101154_bib40","author":"Rosas"},{"issue":"12","key":"10.1016\/j.bbih.2025.101154_bib41","doi-asserted-by":"crossref","first-page":"1231","DOI":"10.1056\/NEJMoa052963","article-title":"STAR\u2217D study team. Bupropion-SR, sertraline, or venlafaxine-XR after failure of SSRIs for depression","volume":"354","author":"Rush","year":"2006","journal-title":"N. Engl. J. Med."},{"issue":"7289","key":"10.1016\/j.bbih.2025.101154_bib42","doi-asserted-by":"crossref","first-page":"763","DOI":"10.1038\/nature08855","article-title":"Impaired hippocampal-prefrontal synchrony in a genetic mouse model of schizophrenia","volume":"464","author":"Sigurdsson","year":"2010","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2025.101154_bib43","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.psychres.2018.12.041","article-title":"Accelerated TMS for depression: a systematic review and meta-analysis","volume":"273","author":"Sonmez","year":"2019","journal-title":"Psychiatry Res."},{"issue":"22","key":"10.1016\/j.bbih.2025.101154_bib44","doi-asserted-by":"crossref","first-page":"617","DOI":"10.15585\/mmwr.mm6722a1","article-title":"Vital signs: trends in state suicide rates - united States, 1999-2016 and circumstances contributing to suicide - 27 states, 2015","volume":"67","author":"Stone","year":"2018","journal-title":"MMWR Morb. Mortal. Wkly. Rep."},{"issue":"6","key":"10.1016\/j.bbih.2025.101154_bib45","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1016\/j.biopsych.2023.04.011","article-title":"Identifying neurophysiological markers of intermittent theta burst stimulation in treatment-resistant depression using transcranial magnetic stimulation-electroencephalography","volume":"94","author":"Strafella","year":"2023","journal-title":"Biol. Psychiatry"},{"key":"10.1016\/j.bbih.2025.101154_bib46","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1016\/j.neuroimage.2017.09.022","article-title":"Towards understanding rTMS mechanism of action: stimulation of the DLPFC causes network-specific increase in functional connectivity","volume":"162","author":"Tik","year":"2017","journal-title":"Neuroimage"},{"key":"10.1016\/j.bbih.2025.101154_bib47","doi-asserted-by":"crossref","first-page":"e26","DOI":"10.1017\/gmh.2016.20","article-title":"Sustainable development goals and mental health: learnings from the contribution of the FundaMentalSDG global initiative","volume":"3","author":"Votruba","year":"2016","journal-title":"Glob Ment Health (Camb)"},{"key":"10.1016\/j.bbih.2025.101154_bib48","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1016\/j.jad.2022.01.047","article-title":"Safety of transcranial magnetic stimulation in unipolar depression: a systematic review and meta-analysis of randomized-controlled trials","volume":"301","author":"Wang","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"3","key":"10.1016\/j.bbih.2025.101154_bib49","doi-asserted-by":"crossref","DOI":"10.1093\/brain\/awx379","article-title":"High-dose spaced theta-burst TMS as a rapid-acting antidepressant in highly refractory depression","volume":"141","author":"Williams","year":"2018","journal-title":"Brain"},{"key":"10.1016\/j.bbih.2025.101154_bib51","series-title":"Preventing Suicide: a Global Imperative","year":"2014"},{"key":"10.1016\/j.bbih.2025.101154_bib52","series-title":"Suicide [Internet]","year":"2024"},{"issue":"7","key":"10.1016\/j.bbih.2025.101154_bib53","doi-asserted-by":"crossref","first-page":"2764","DOI":"10.1038\/s41380-022-01935-7","article-title":"Suicidal behavior across a broad range of psychiatric disorders","volume":"28","author":"Xu","year":"2023","journal-title":"Mol. Psychiatr."},{"issue":"4","key":"10.1016\/j.bbih.2025.101154_bib55","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.165271","article-title":"Pursuing personalized medicine for depression by targeting the lateral or medial prefrontal cortex with deep TMS","volume":"8","author":"Zangen","year":"2023","journal-title":"JCI Insight"},{"issue":"5","key":"10.1016\/j.bbih.2025.101154_bib56","doi-asserted-by":"crossref","first-page":"1848","DOI":"10.1177\/0300060518817417","article-title":"Repetitive transcranial magnetic stimulation increases serum brain-derived neurotrophic factor and decreases interleukin-1\u03b2 and tumor necrosis factor-\u03b1 in elderly patients with refractory depression","volume":"47","author":"Zhao","year":"2019","journal-title":"J. Int. Med. Res."},{"issue":"1","key":"10.1016\/j.bbih.2025.101154_bib57","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.biopsych.2023.12.013","article-title":"Comparisons of accelerated continuous and intermittent theta burst stimulation for treatment-resistant depression and suicidal ideation","volume":"96","author":"Zhao","year":"2024","journal-title":"Biol. Psychiatry"}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354625002121?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354625002121?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,3,19]],"date-time":"2026-03-19T00:43:01Z","timestamp":1773880981000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354625002121"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,2]]},"references-count":53,"alternative-id":["S2666354625002121"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2025.101154","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,2]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Accelerated Theta Burst Stimulation Transcranial Magnetic Stimulation (iTBS-TMS) Pururauka program for severe depressive episode and suicide ideation","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2025.101154","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2025 The Author(s). Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101154"}}