{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,20]],"date-time":"2026-10-20T16:33:43Z","timestamp":1792514023435,"version":"4.5.0"},"reference-count":47,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,3,1]],"date-time":"2026-03-01T00:00:00Z","timestamp":1772323200000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,2,3]],"date-time":"2026-02-03T00:00:00Z","timestamp":1770076800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82271172"],"award-info":[{"award-number":["82271172"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82401358"],"award-info":[{"award-number":["82401358"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82171150"],"award-info":[{"award-number":["82171150"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["82196821"],"award-info":[{"award-number":["82196821"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007129","name":"Shandong Province Natural Science Foundation","doi-asserted-by":"publisher","award":["ZR2024QH421"],"award-info":[{"award-number":["ZR2024QH421"]}],"id":[{"id":"10.13039\/501100007129","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100002858","name":"China Postdoctoral Science Foundation","doi-asserted-by":"publisher","award":["2024M761821"],"award-info":[{"award-number":["2024M761821"]}],"id":[{"id":"10.13039\/501100002858","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2026,3]]},"DOI":"10.1016\/j.bbih.2026.101193","type":"journal-article","created":{"date-parts":[[2026,2,7]],"date-time":"2026-02-07T00:42:49Z","timestamp":1770424969000},"page":"101193","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":3,"special_numbering":"C","title":["A Stress-Neuroendocrine-Myeloid Inflammation Axis Is Associated with the Progression of M\u00e9ni\u00e8re's Disease"],"prefix":"10.1016","volume":"52","author":[{"given":"Xiaofei","family":"Li","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongdong","family":"Song","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tongtong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yafeng","family":"Lyu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huirong","family":"Jian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yawei","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jing","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wenjuan","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yinghui","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhaomin","family":"Fan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Na","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daogong","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haibo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2026.101193_bib1","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1097\/MOH.0000000000000589","article-title":"Regulation of stress-induced hematopoiesis","volume":"27","author":"Anderson","year":"2020","journal-title":"Curr. Opin. Hematol."},{"key":"10.1016\/j.bbih.2026.101193_bib2","doi-asserted-by":"crossref","first-page":"595","DOI":"10.1016\/S0022-3999(97)00184-0","article-title":"Stress and symptoms of Meni\u00e8re's disease: a time-series analysis","volume":"43","author":"Andersson","year":"1997","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.bbih.2026.101193_bib3","doi-asserted-by":"crossref","first-page":"1905","DOI":"10.1016\/S0140-6736(09)60326-3","article-title":"Glucocorticoid resistance in inflammatory diseases","volume":"373","author":"Barnes","year":"2009","journal-title":"Lancet"},{"key":"10.1016\/j.bbih.2026.101193_bib4","doi-asserted-by":"crossref","first-page":"421","DOI":"10.1007\/s00234-019-02155-7","article-title":"The value of four stage vestibular hydrops grading and asymmetric perilymphatic enhancement in the diagnosis of Meniere's disease on MRI","volume":"61","author":"Bernaerts","year":"2019","journal-title":"Neuroradiology"},{"key":"10.1016\/j.bbih.2026.101193_bib5","doi-asserted-by":"crossref","first-page":"385","DOI":"10.2307\/2136404","article-title":"A global measure of perceived stress","volume":"24","author":"Cohen","year":"1983","journal-title":"J. Health Soc. Behav."},{"key":"10.1016\/j.bbih.2026.101193_bib6","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.cobeha.2019.01.008","article-title":"The conserved transcriptional response to adversity","volume":"28","author":"Cole","year":"2019","journal-title":"Curr. Opin. Behav. Sci."},{"key":"10.1016\/j.bbih.2026.101193_bib7","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1111\/imm.13863","article-title":"Multiomic-based immune response profiling in migraine, vestibular migraine and Meniere's disease","volume":"173","author":"Cruz-Granados","year":"2024","journal-title":"Immunology"},{"key":"10.1016\/j.bbih.2026.101193_bib8","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1016\/j.otc.2010.05.004","article-title":"Allergy and its relation to Meniere's disease","volume":"43","author":"Derebery","year":"2010","journal-title":"Otolaryngol Clin North Am"},{"key":"10.1016\/j.bbih.2026.101193_bib9","doi-asserted-by":"crossref","DOI":"10.1016\/j.clim.2023.109632","article-title":"Single-cell immune profiling of Meniere Disease patients","volume":"252","author":"Flook","year":"2023","journal-title":"Clin. Immunol."},{"key":"10.1016\/j.bbih.2026.101193_bib10","doi-asserted-by":"crossref","first-page":"5974","DOI":"10.1038\/s41598-018-23911-4","article-title":"Proinflammatory cytokines and response to molds in mononuclear cells of patients with Meniere disease","volume":"8","author":"Frejo","year":"2018","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2026.101193_bib11","doi-asserted-by":"crossref","first-page":"49","DOI":"10.21053\/ceo.2021.00920","article-title":"Cytokines and inflammation in meniere disease","volume":"15","author":"Frejo","year":"2022","journal-title":"Clin. Exp Otorhinolaryngol."},{"key":"10.1016\/j.bbih.2026.101193_bib12","doi-asserted-by":"crossref","first-page":"866","DOI":"10.1016\/j.anl.2023.03.006","article-title":"Relationship between stress levels and endolymphatic space volume in Meniere's disease","volume":"50","author":"Fujita","year":"2023","journal-title":"Auris Nasus Larynx"},{"key":"10.1016\/j.bbih.2026.101193_bib13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0026759","article-title":"High prevalence of systemic autoimmune diseases in patients with Meniere's disease","volume":"6","author":"Gazquez","year":"2011","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2026.101193_bib14","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1038\/s41586-023-06568-6","article-title":"The \u03b2(1)-adrenergic receptor links sympathetic nerves to T cell exhaustion","volume":"622","author":"Globig","year":"2023","journal-title":"Nature"},{"key":"10.1016\/j.bbih.2026.101193_bib15","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1136\/annrheumdis-2019-215782","article-title":"Transcriptome reprogramming and myeloid skewing in haematopoietic stem and progenitor cells in systemic lupus erythematosus","volume":"79","author":"Grigoriou","year":"2020","journal-title":"Ann. Rheum. Dis."},{"key":"10.1016\/j.bbih.2026.101193_bib16","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1016\/j.bbi.2018.05.014","article-title":"Perioperative inhibition of beta-adrenergic and COX2 signaling in a clinical trial in breast cancer patients improves tumor Ki-67 expression, serum cytokine levels, and PBMCs transcriptome","volume":"73","author":"Haldar","year":"2018","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101193_bib17","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.heares.2017.12.009","article-title":"Immune cells and non-immune cells with immune function in mammalian cochleae","volume":"362","author":"Hu","year":"2018","journal-title":"Hear. Res."},{"key":"10.1016\/j.bbih.2026.101193_bib18","doi-asserted-by":"crossref","first-page":"3143","DOI":"10.3389\/fimmu.2018.03143","article-title":"Control of Leukocyte trafficking by stress-associated hormones","volume":"9","author":"Ince","year":"2018","journal-title":"Front. Immunol."},{"key":"10.1016\/j.bbih.2026.101193_bib19","doi-asserted-by":"crossref","DOI":"10.3389\/fneur.2022.804777","article-title":"Relationship between the onset of m\u00e9ni\u00e8re's disease and sympathetic hyperactivity","volume":"13","author":"Ishii","year":"2022","journal-title":"Front. Neurol."},{"key":"10.1016\/j.bbih.2026.101193_bib20","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1136\/gutjnl-2020-322712","article-title":"Amelioration of systemic inflammation in advanced chronic liver disease upon beta-blocker therapy translates into improved clinical outcomes","volume":"70","author":"Jachs","year":"2021","journal-title":"Gut"},{"key":"10.1016\/j.bbih.2026.101193_bib21","doi-asserted-by":"crossref","first-page":"194","DOI":"10.1016\/j.genhosppsych.2023.07.008","article-title":"Validation of the Chinese version of the Perceived Stress Scale-10 integrating exploratory graph analysis and confirmatory factor analysis","volume":"84","author":"Jiang","year":"2023","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.bbih.2026.101193_bib22","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/j.bbi.2014.10.007","article-title":"beta2-Adrenergic receptors in immunity and inflammation: stressing NF-kappaB","volume":"45","author":"Kolmus","year":"2015","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101193_bib23","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1097\/MOO.0000000000000909","article-title":"Infectious causes and mimickers of meniere's disease","volume":"31","author":"Kurtzman","year":"2023","journal-title":"Curr. Opin. Otolaryngol. Head Neck Surg."},{"key":"10.1016\/j.bbih.2026.101193_bib24","doi-asserted-by":"crossref","DOI":"10.1038\/s41577-025-01199-6","article-title":"Connection and communication between the nervous and immune systems","author":"Leunig","year":"2025","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2026.101193_bib25","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3233\/VES-150549","article-title":"Diagnostic criteria for Meniere's disease","volume":"25","author":"Lopez-Escamez","year":"2015","journal-title":"J. Vestib. Res."},{"key":"10.1016\/j.bbih.2026.101193_bib26","doi-asserted-by":"crossref","first-page":"5","DOI":"10.1053\/meta.2002.33184","article-title":"Neuroendocrine aspects of the response to stress","volume":"51","author":"Miller","year":"2002","journal-title":"Metabolism"},{"key":"10.1016\/j.bbih.2026.101193_bib27","doi-asserted-by":"crossref","DOI":"10.3390\/jcm10184052","article-title":"Clinical and cytokine profile in patients with early and late onset meniere disease","volume":"10","author":"Moleon","year":"2021","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbih.2026.101193_bib28","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1038\/nrendo.2018.5","article-title":"Adrenal disease: imitating the cortisol profile improves the immune system","volume":"14","author":"M\u00fcller","year":"2018","journal-title":"Nat. Rev. Endocrinol."},{"key":"10.1016\/j.bbih.2026.101193_bib29","doi-asserted-by":"crossref","DOI":"10.1038\/nrdp.2016.28","article-title":"Meniere's disease","volume":"2","author":"Nakashima","year":"2016","journal-title":"Nat. Rev. Dis. Primers"},{"key":"10.1016\/j.bbih.2026.101193_bib30","doi-asserted-by":"crossref","first-page":"1758","DOI":"10.1002\/jnr.21625","article-title":"Bone marrow-derived cells expressing Iba1 are constitutively present as resident tissue macrophages in the mouse cochlea","volume":"86","author":"Okano","year":"2008","journal-title":"J. Neurosci. Res."},{"key":"10.1016\/j.bbih.2026.101193_bib31","doi-asserted-by":"crossref","first-page":"1903","DOI":"10.3174\/ajnr.A4822","article-title":"Blood-Labyrinth barrier permeability in meniere disease and idiopathic sudden sensorineural hearing loss: findings on delayed postcontrast 3D-FLAIR MRI","volume":"37","author":"Pakdaman","year":"2016","journal-title":"AJNR Am J. Neuroradiol."},{"key":"10.1016\/j.bbih.2026.101193_bib32","doi-asserted-by":"crossref","first-page":"16574","DOI":"10.1073\/pnas.1310655110","article-title":"Social stress up-regulates inflammatory gene expression in the leukocyte transcriptome via \u03b2-adrenergic induction of myelopoiesis","volume":"110","author":"Powell","year":"2013","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"key":"10.1016\/j.bbih.2026.101193_bib33","doi-asserted-by":"crossref","first-page":"406","DOI":"10.1016\/S0140-6736(08)61161-7","article-title":"Meniere's disease","volume":"372","author":"Sajjadi","year":"2008","journal-title":"Lancet (London, England)"},{"key":"10.1016\/j.bbih.2026.101193_bib34","doi-asserted-by":"crossref","first-page":"171","DOI":"10.3389\/fphar.2015.00171","article-title":"Adrenergic regulation of innate immunity: a review","volume":"6","author":"Scanzano","year":"2015","journal-title":"Front. Pharmacol."},{"key":"10.1016\/j.bbih.2026.101193_bib35","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1038\/s41577-020-0387-1","article-title":"Neuronal regulation of immunity: why, how and where?","volume":"21","author":"Schiller","year":"2021","journal-title":"Nat. Rev. Immunol."},{"key":"10.1016\/j.bbih.2026.101193_bib36","doi-asserted-by":"crossref","first-page":"4651","DOI":"10.1158\/1078-0432.CCR-17-0152","article-title":"Perioperative COX-2 and beta-adrenergic blockade improves metastatic biomarkers in breast cancer patients in a Phase-II randomized trial","volume":"23","author":"Shaashua","year":"2017","journal-title":"Clin. Cancer Res."},{"key":"10.1016\/j.bbih.2026.101193_bib37","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1177\/0961203318815595","article-title":"The Perceived Stress Scale-10 (PSS-10) is reliable and has construct validity in Chinese patients with systemic lupus erythematosus","volume":"28","author":"Sun","year":"2019","journal-title":"Lupus"},{"key":"10.1016\/j.bbih.2026.101193_bib38","doi-asserted-by":"crossref","first-page":"300","DOI":"10.1159\/000089412","article-title":"Personal factors involved in onset or progression of Meniere's disease and low-tone sensorineural hearing loss","volume":"67","author":"Takahashi","year":"2005","journal-title":"ORL J. Otorhinolaryngol. Relat Spec."},{"key":"10.1016\/j.bbih.2026.101193_bib40","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1097\/MAO.0000000000000732","article-title":"Mental health and subjective well-being of individuals with meniere's: Cross-sectional analysis in the UK biobank","volume":"36","author":"Tyrrell","year":"2015","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.bbih.2026.101193_bib41","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.immuni.2018.05.004","article-title":"Sympathetic neuronal activation triggers Myeloid progenitor proliferation and differentiation","volume":"49","author":"Vasamsetti","year":"2018","journal-title":"Immunity"},{"key":"10.1016\/j.bbih.2026.101193_bib42","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.neubiorev.2021.06.013","article-title":"Glucocorticoid resistance and \u03b22-adrenergic receptor signaling pathways promote peripheral pro-inflammatory conditions associated with chronic psychological stress: a systematic review across species","volume":"128","author":"Walsh","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbih.2026.101193_bib43","article-title":"Intratympanic corticosteroids for Meniere's disease","volume":"2","author":"Webster","year":"2023","journal-title":"Cochrane Database Syst. Rev."},{"key":"10.1016\/j.bbih.2026.101193_bib44","doi-asserted-by":"crossref","first-page":"13820","DOI":"10.1523\/JNEUROSCI.1671-13.2013","article-title":"Stress-induced recruitment of bone marrow-derived monocytes to the brain promotes anxiety-like behavior","volume":"33","author":"Wohleb","year":"2013","journal-title":"J. Neurosci."},{"key":"10.1016\/j.bbih.2026.101193_bib45","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1097\/MAO.0000000000001592","article-title":"Stress and unusual events exacerbate symptoms in Meniere's disease: a longitudinal Study","volume":"39","author":"Yeo","year":"2018","journal-title":"Otol. Neurotol."},{"key":"10.1016\/j.bbih.2026.101193_bib46","doi-asserted-by":"crossref","DOI":"10.1155\/2020\/8851525","article-title":"Cisplatin-Induced Stria vascularis damage is associated with inflammation and Fibrosis","volume":"2020","author":"Zhang","year":"2020","journal-title":"Neural Plast."},{"key":"10.1016\/j.bbih.2026.101193_bib47","doi-asserted-by":"crossref","first-page":"1249","DOI":"10.1038\/s41467-023-36949-4","article-title":"Serum\/glucocorticoid-inducible kinase 1 deficiency induces NLRP3 inflammasome activation and autoinflammation of macrophages in a murine endolymphatic hydrops model","volume":"14","author":"Zhang","year":"2023","journal-title":"Nat. Commun."},{"key":"10.1016\/j.bbih.2026.101193_bib48","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-022-20774-8","article-title":"Elevated G-CSF, IL8, and HGF in patients with definite Meniere's disease may indicate the role of NET formation in triggering autoimmunity and autoinflammation","volume":"12","author":"Zou","year":"2022","journal-title":"Sci. Rep."}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626000268?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626000268?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,5,16]],"date-time":"2026-05-16T08:10:48Z","timestamp":1778919048000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354626000268"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,3]]},"references-count":47,"alternative-id":["S2666354626000268"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101193","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,3]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"A Stress-Neuroendocrine-Myeloid Inflammation Axis Is Associated with the Progression of M\u00e9ni\u00e8re's Disease","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101193","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101193"}}