{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:57:59Z","timestamp":1781053079425,"version":"3.54.1"},"reference-count":16,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,4,11]],"date-time":"2026-04-11T00:00:00Z","timestamp":1775865600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["UM1AI068636"],"award-info":[{"award-number":["UM1AI068636"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["#R01 MH115849"],"award-info":[{"award-number":["#R01 MH115849"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["R01 AG062387"],"award-info":[{"award-number":["R01 AG062387"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbih.2026.101241","type":"journal-article","created":{"date-parts":[[2026,4,14]],"date-time":"2026-04-14T17:00:40Z","timestamp":1776186040000},"page":"101241","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Linking neuroinflammation and neurodegeneration to cognitive decline in HIV"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4931-752X","authenticated-orcid":false,"given":"Ronald J.","family":"Ellis","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajing","family":"Bao","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Huichao","family":"Chen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Letendre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmed","family":"Chenna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brandon","family":"Yee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Winslow","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christos","family":"Petropoulos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shelli","family":"Farhadian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shibani S.","family":"Mukerji","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Albert","family":"Anderson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"1","key":"10.1016\/j.bbih.2026.101241_bib1","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1080\/07853890.2020.1814962","article-title":"Important role of microglia in HIV-1 associated neurocognitive disorders and the molecular pathways implicated in its pathogenesis","volume":"53","author":"Borrajo","year":"2021","journal-title":"Ann. Med."},{"issue":"36","key":"10.1016\/j.bbih.2026.101241_bib2","doi-asserted-by":"crossref","first-page":"22385","DOI":"10.1074\/jbc.272.36.22385","article-title":"The Tat protein of HIV-1 induces tumor necrosis factor-alpha production. Implications for HIV-1-associated neurological diseases","volume":"272","author":"Chen","year":"1997","journal-title":"J. Biol. Chem."},{"issue":"3","key":"10.1016\/j.bbih.2026.101241_bib3","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1007\/s13365-022-01081-4","article-title":"Higher cerebrospinal fluid biomarkers of neuronal injury in HIV-associated neurocognitive impairment","volume":"28","author":"Ellis","year":"2022","journal-title":"J. Neurovirol."},{"issue":"3","key":"10.1016\/j.bbih.2026.101241_bib4","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1097\/WCO.0b013e32834695fb","article-title":"Current understanding of HIV-associated neurocognitive disorders pathogenesis","volume":"24","author":"Gannon","year":"2011","journal-title":"Curr. Opin. Neurol."},{"issue":"11","key":"10.1016\/j.bbih.2026.101241_bib7","doi-asserted-by":"crossref","DOI":"10.1001\/jamanetworkopen.2023.44194","article-title":"Plasma biomarkers of alzheimer disease in women with and without HIV","volume":"6","author":"Li","year":"2023","journal-title":"JAMA Netw. Open"},{"issue":"5","key":"10.1016\/j.bbih.2026.101241_bib8","doi-asserted-by":"crossref","first-page":"400","DOI":"10.2174\/1570162X14666160324124558","article-title":"Mechanisms of HIV neuropathogenesis: role of cellular communication systems","volume":"14","author":"Malik","year":"2016","journal-title":"Curr. HIV Res."},{"issue":"4","key":"10.1016\/j.bbih.2026.101241_bib10","doi-asserted-by":"crossref","first-page":"946","DOI":"10.1093\/infdis\/jiae623","article-title":"Plasma neurofilament light chain and glial fibrillary acidic protein as biomarkers of cognitive decline in people with human immunodeficiency virus","volume":"231","author":"Mukerji","year":"2025","journal-title":"J. Infect. Dis."},{"issue":"11","key":"10.1016\/j.bbih.2026.101241_bib23","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1097\/QAD.0b013e32832c4152","article-title":"AIDS Clinical Trials Group 736 Study Team. Impact of combination antiretroviral therapy on cerebrospinal fluid HIV RNA and neurocognitive performance","volume":"23","author":"Marra","year":"2009","journal-title":"AIDS"},{"issue":"11","key":"10.1016\/j.bbih.2026.101241_bib11","doi-asserted-by":"crossref","first-page":"3505","DOI":"10.1093\/brain\/awab223","article-title":"Plasma GFAP is an early marker of amyloid-\u03b2 but not tau pathology in Alzheimer's disease","volume":"144","author":"Pereira","year":"2021","journal-title":"Brain J. Neurol."},{"issue":"5","key":"10.1016\/j.bbih.2026.101241_bib12","doi-asserted-by":"crossref","first-page":"702","DOI":"10.1007\/s13365-018-0695-4","article-title":"Plasma neuronal exosomes serve as biomarkers of cognitive impairment in HIV infection and Alzheimer's disease","volume":"25","author":"Pulliam","year":"2019","journal-title":"J. Neurovirol."},{"key":"10.1016\/j.bbih.2026.101241_bib13","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1016\/j.pneurobio.2016.04.003","article-title":"HIV\/neuroAIDS biomarkers","volume":"157","author":"Rahimian","year":"2017","journal-title":"Prog. Neurobiol."},{"issue":"13","key":"10.1016\/j.bbih.2026.101241_bib22","doi-asserted-by":"crossref","first-page":"1314","DOI":"10.1212\/01.wnl.0000268487.78753.0f","article-title":"ACTG A5090 Team. A multicenter trial of selegiline transdermal system for HIV-associated cognitive impairment","volume":"69","author":"Schifitto","year":"2007","journal-title":"Neurology"},{"issue":"3","key":"10.1016\/j.bbih.2026.101241_bib15","doi-asserted-by":"crossref","first-page":"924","DOI":"10.1111\/jgs.17569","article-title":"Polypharmacy in older adults with HIV infection: effects on the brain","volume":"70","author":"Smith","year":"2022","journal-title":"J. Am. Geriatr. Soc."},{"issue":"2","key":"10.1016\/j.bbih.2026.101241_bib16","doi-asserted-by":"crossref","first-page":"156","DOI":"10.1007\/s13365-023-01116-4","article-title":"Blood and cerebrospinal fluid biomarker changes in patients with HIV-associated neurocognitive impairment treated with lithium: analysis from a randomised placebo-controlled trial","volume":"29","author":"Thela","year":"2023","journal-title":"J. Neurovirol."},{"issue":"19","key":"10.1016\/j.bbih.2026.101241_bib18","doi-asserted-by":"crossref","first-page":"e2610","DOI":"10.1212\/WNL.0000000000010752","article-title":"Global prevalence and burden of HIV-associated neurocognitive disorder: a meta-analysis","volume":"95","author":"Wang","year":"2020","journal-title":"Neurology"},{"issue":"10","key":"10.1016\/j.bbih.2026.101241_bib20","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1212\/WNL.0b013e3181f11bd8","article-title":"Cardiovascular risk factors associated with lower baseline cognitive performance in HIV-positive persons","volume":"75","author":"Wright","year":"2010","journal-title":"Neurology"}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626000748?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626000748?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T00:08:36Z","timestamp":1781050116000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354626000748"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":16,"alternative-id":["S2666354626000748"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101241","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Linking neuroinflammation and neurodegeneration to cognitive decline in HIV","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101241","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101241"}}