{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:22:14Z","timestamp":1783128134160,"version":"3.54.6"},"reference-count":100,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,7,1]],"date-time":"2026-07-01T00:00:00Z","timestamp":1782864000000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T00:00:00Z","timestamp":1779148800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000054","name":"National Institutes of Health National Cancer Institute","doi-asserted-by":"publisher","award":["R00CA273424"],"award-info":[{"award-number":["R00CA273424"]}],"id":[{"id":"10.13039\/100000054","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000069","name":"National Institute of Arthritis and Musculoskeletal and Skin Diseases","doi-asserted-by":"publisher","award":["R01AR079445"],"award-info":[{"award-number":["R01AR079445"]}],"id":[{"id":"10.13039\/100000069","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100009455","name":"West Virginia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100009455","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100018239","name":"Cancer Institute, West Virginia University","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100018239","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2026,7]]},"DOI":"10.1016\/j.bbih.2026.101262","type":"journal-article","created":{"date-parts":[[2026,5,19]],"date-time":"2026-05-19T22:56:57Z","timestamp":1779231417000},"page":"101262","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Chronotherapeutic administration of neoadjuvant chemotherapy reduces cancer-related fatigue-like behavior"],"prefix":"10.1016","volume":"54","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0295-3943","authenticated-orcid":false,"given":"Claire O.","family":"Kisamore","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caleb A.","family":"Kisamore","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jayla M.","family":"Boyd","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul J.","family":"Owolabi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Divya B.","family":"Kadri","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alan D.","family":"Mizener","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emidio E.","family":"Pistilli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"suffix":"II","given":"William H.","family":"Walker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2026.101262_bib1","article-title":"Paclitaxel resistance in breast cancer: current challenges and recent advanced therapeutic strategies","volume":"43","author":"Abouzeid","year":"2025","journal-title":"Cancer Treat Res Commun"},{"issue":"5","key":"10.1016\/j.bbih.2026.101262_bib2","doi-asserted-by":"crossref","first-page":"1015","DOI":"10.1002\/ijc.35234","article-title":"Chronotherapy in head and neck cancer: a systematic review and meta-analysis","volume":"156","author":"Abusamak","year":"2025","journal-title":"Int. J. Cancer"},{"issue":"5","key":"10.1016\/j.bbih.2026.101262_bib4","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1177\/07487304251349893","article-title":"Time of day-dependent responses to cisplatin treatment in a male mouse model of hepatoma","volume":"40","author":"Akyel","year":"2025","journal-title":"J Biol Rhythms"},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib3","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1007\/s00204-025-03968-7","article-title":"The impact of circadian rhythm disruption on oxaliplatin tolerability and pharmacokinetics in Cry1-\/-Cry2-\/- mice under constant darkness","volume":"99","author":"Akyel","year":"2025","journal-title":"Arch. Toxicol."},{"key":"10.1016\/j.bbih.2026.101262_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.774347","article-title":"Chronic fatigue in cancer, brain connectivity and reluctance to engage in physical activity: a mini-review","volume":"11","author":"Andr\u00e9","year":"2021","journal-title":"Front. Oncol."},{"issue":"3","key":"10.1016\/j.bbih.2026.101262_bib6","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/j.1439-0310.1979.tb00290.x","article-title":"Circadian rhythms: influences of internal and external factors on the period measured in constant conditions","volume":"49","author":"Aschoff","year":"1979","journal-title":"Z. Tierpsychol."},{"key":"10.1016\/j.bbih.2026.101262_bib7","doi-asserted-by":"crossref","first-page":"328","DOI":"10.1016\/j.neuropharm.2014.05.039","article-title":"Mouse social stress induces increased fear conditioning, helplessness and fatigue to physical challenge together with markers of altered immune and dopamine function","volume":"85","author":"Azzinnari","year":"2014","journal-title":"Neuropharmacology"},{"key":"10.1016\/j.bbih.2026.101262_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.116362","article-title":"Upcycling the anthracyclines: new mechanisms of action, toxicology, and pharmacology","volume":"459","author":"Bayles","year":"2023","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib9","first-page":"51","article-title":"Patterns of fatigue and activity and rest during adjuvant breast cancer chemotherapy","volume":"25","author":"Berger","year":"1998","journal-title":"Oncol. Nurs. Forum"},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib10","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1002\/jcsm.12294","article-title":"Dysregulation of metabolic\u2010associated pathways in muscle of breast cancer patients: preclinical evaluation of interleukin\u201015 targeting fatigue","volume":"9","author":"Bohlen","year":"2018","journal-title":"J. Cachexia Sarcopenia Muscle"},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib11","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1038\/s41523-024-00676-w","article-title":"Dose dense versus 3 weekly AC during neoadjuvant chemoimmunotherapy for triple negative breast cancer","volume":"10","author":"Bonadio","year":"2024","journal-title":"NPJ Breast Cancer"},{"key":"10.1016\/j.bbih.2026.101262_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/srep41220","article-title":"Time-of-day dictates transcriptional inflammatory responses to cytotoxic chemotherapy","volume":"7","author":"Borniger","year":"2017","journal-title":"Sci. Rep."},{"issue":"7","key":"10.1016\/j.bbih.2026.101262_bib13","doi-asserted-by":"crossref","first-page":"863","DOI":"10.1016\/j.bbi.2007.03.013","article-title":"Cancer-related fatigue: links with inflammation in cancer patients and survivors","volume":"21","author":"Bower","year":"2007","journal-title":"Brain Behav. Immun."},{"issue":"10","key":"10.1016\/j.bbih.2026.101262_bib14","doi-asserted-by":"crossref","first-page":"597","DOI":"10.1038\/nrclinonc.2014.127","article-title":"Cancer-related fatigue\u2014mechanisms, risk factors, and treatments","volume":"11","author":"Bower","year":"2014","journal-title":"Nat. Rev. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib16","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1200\/JCO.2000.18.4.743","article-title":"Fatigue in breast cancer survivors: occurrence, correlates, and impact on quality of life","volume":"18","author":"Bower","year":"2000","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib17","doi-asserted-by":"crossref","first-page":"751","DOI":"10.1002\/cncr.21671","article-title":"Fatigue in long\u2010term breast carcinoma survivors","volume":"106","author":"Bower","year":"2006","journal-title":"Cancer"},{"issue":"0","key":"10.1016\/j.bbih.2026.101262_bib15","first-page":"S48","article-title":"Inflammation and cancer-related fatigue: mechanisms, contributing factors, and treatment implications","volume":"30","author":"Bower","year":"2012","journal-title":"Brain Behav. Immun."},{"issue":"12","key":"10.1016\/j.bbih.2026.101262_bib18","doi-asserted-by":"crossref","first-page":"1046","DOI":"10.1093\/jnci\/82.12.1046","article-title":"Phase I trial of 5-day continuous venous infusion of oxaliplatin at circadian rhythm-modulated rate compared with constant rate","volume":"82","author":"Caussanel","year":"1990","journal-title":"J Natl Cancer Inst"},{"key":"10.1016\/j.bbih.2026.101262_bib19","first-page":"1507","article-title":"Retrospective analysis of chronomodulated chemotherapy versus conventional chemotherapy with paclitaxel, carboplatin, and 5-fluorouracil in patients with recurrent and\/or metastatic head and neck squamous cell carcinoma","volume":"6","author":"Chen","year":"2013","journal-title":"OncoTargets Ther."},{"issue":"11","key":"10.1016\/j.bbih.2026.101262_bib20","article-title":"Exercise for the management of cancer\u2010related fatigue in adults","volume":"11","author":"Cramp","year":"2012","journal-title":"Cochrane Database Syst. Rev."},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib23","first-page":"302","article-title":"Inflammatory status along the brain-liver axis in animals vulnerable to prenatal stress: Sex-related implications for stress-induced comorbidities","volume":"15","author":"D'Aprile","year":"2025","journal-title":"Transl. Psychiatry"},{"key":"10.1016\/j.bbih.2026.101262_bib21","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2025.106035","article-title":"The metabolic basis of cancer-related fatigue","volume":"169","author":"Dantzer","year":"2025","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"2","key":"10.1016\/j.bbih.2026.101262_bib22","doi-asserted-by":"crossref","first-page":"164","DOI":"10.3109\/09553000903419304","article-title":"Three endpoints of in vivo tumour radiobiology and their statistical estimation","volume":"86","author":"Demidenko","year":"2010","journal-title":"Intl J Radiat Biol"},{"issue":"488","key":"10.1016\/j.bbih.2026.101262_bib24","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.aav0936","article-title":"Resistance to neoadjuvant chemotherapy in triple negative breast cancer mediated by a reversible drug-tolerant state","volume":"11","author":"Echeverria","year":"2019","journal-title":"Sci. Transl. Med."},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib25","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1007\/BF00684890","article-title":"Phase I study of oxaliplatin in patients with advanced cancer","volume":"25","author":"Extra","year":"1990","journal-title":"Cancer Chemother. Pharmacol."},{"issue":"6","key":"10.1016\/j.bbih.2026.101262_bib26","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.annonc.2020.02.016","article-title":"Cancer-related fatigue: ESMO clinical practice guidelines for diagnosis and treatment","volume":"31","author":"Fabi","year":"2020","journal-title":"Ann. Oncol."},{"issue":"10","key":"10.1016\/j.bbih.2026.101262_bib27","doi-asserted-by":"crossref","first-page":"1860","DOI":"10.1002\/cncr.30527","article-title":"Survivorship after lower gastrointestinal cancer: patient\u2010reported outcomes and planning for care","volume":"123","author":"Frick","year":"2017","journal-title":"Cancer"},{"issue":"22","key":"10.1016\/j.bbih.2026.101262_bib28","doi-asserted-by":"crossref","first-page":"3562","DOI":"10.1200\/JCO.2006.06.1440","volume":"24","author":"Giacchetti","year":"2006","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbih.2026.101262_bib29","doi-asserted-by":"crossref","first-page":"240","DOI":"10.1186\/1471-2407-6-240","article-title":"Fatigue states after cancer treatment occur both in association with, and independent of, mood disorder: a longitudinal study","volume":"6","author":"Goldstein","year":"2006","journal-title":"BMC Cancer"},{"issue":"7","key":"10.1016\/j.bbih.2026.101262_bib30","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.4103\/jcrt.JCRT_883_17","article-title":"Induction chronomodulated chemotherapy plus radiotherapy for nasopharyngeal carcinoma: a Phase II prospective randomized study","volume":"14","author":"Gou","year":"2018","journal-title":"J Cancer Res Ther"},{"issue":"6","key":"10.1016\/j.bbih.2026.101262_bib31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/sj.bjc.6600168","article-title":"Circadian optimisation of irinotecan and oxaliplatin efficacy in mice with Glasgow osteosarcoma","volume":"86","author":"Granda","year":"2002","journal-title":"Br. J. Cancer"},{"issue":"9","key":"10.1016\/j.bbih.2026.101262_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/cpz1.70195","article-title":"The effort-based forage task: an ethological behavioral test for assessing motivation and apathy-related behavior in mice","volume":"5","author":"Grayson","year":"2025","journal-title":"Curr. Protoc."},{"issue":"8","key":"10.1016\/j.bbih.2026.101262_bib33","doi-asserted-by":"crossref","DOI":"10.1111\/gbb.12578","article-title":"A novel mutation in Slc2a4 as a mouse model of fatigue","volume":"18","author":"Groot","year":"2019","journal-title":"Genes Brain Behav"},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib34","first-page":"55","article-title":"Origins of timed cancer treatment: early marker rhythm-guided individualized chronochemotherapy","volume":"6","author":"Halberg","year":"2006","journal-title":"J Exp Ther Oncol"},{"issue":"12","key":"10.1016\/j.bbih.2026.101262_bib35","doi-asserted-by":"crossref","first-page":"1665","DOI":"10.1080\/0284186X.2017.1342862","article-title":"Mindfulness-based interventions for women with breast cancer: an updated systematic review and meta-analysis","volume":"56","author":"Haller","year":"2017","journal-title":"Acta Oncol"},{"issue":"4043","key":"10.1016\/j.bbih.2026.101262_bib36","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1126\/science.177.4043.80","article-title":"Increased tolerance of leukemic mice to Arabinosyl cytosine with schedule adjusted to circadian System","volume":"177","author":"Haus","year":"1972","journal-title":"Science"},{"issue":"S1","key":"10.1016\/j.bbih.2026.101262_bib37","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1634\/theoncologist.12-S1-4","article-title":"Cancer-Related fatigue: the Scale of the problem","volume":"12","author":"Hofman","year":"2007","journal-title":"Oncologist"},{"issue":"4695","key":"10.1016\/j.bbih.2026.101262_bib38","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1126\/science.3883493","article-title":"Circadian timing of cancer chemotherapy","volume":"228","author":"Hrushesky","year":"1985","journal-title":"Science"},{"issue":"7","key":"10.1016\/j.bbih.2026.101262_bib39","doi-asserted-by":"crossref","first-page":"1403","DOI":"10.1200\/JCO.1993.11.7.1403","article-title":"Circadian cancer therapy","volume":"11","author":"Hrushesky","year":"1993","journal-title":"J. Clin. Oncol."},{"issue":"35","key":"10.1016\/j.bbih.2026.101262_bib40","article-title":"Application of biomarkers in the assessment and treatment of cancer-related fatigue","volume":"4","author":"Hu","year":"2025","journal-title":"Holist Integr Oncol"},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib41","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/s41467-023-35979-2","article-title":"Influence of circadian clocks on adaptive immunity and vaccination responses","volume":"14","author":"Ince","year":"2023","journal-title":"Nat Comm"},{"issue":"3","key":"10.1016\/j.bbih.2026.101262_bib42","first-page":"237","article-title":"Functional and molecular characterisation of EO771.LMB tumours, a new C57BL\/6-mouse-derived model of spontaneously metastatic mammary cancer","volume":"8","author":"Johnstone","year":"2015","journal-title":"Dis Models Mech."},{"issue":"3","key":"10.1016\/j.bbih.2026.101262_bib43","article-title":"Evaluation of reference genes for gene expression studies in mouse and N2a cell ischemic stroke models using quantitative real-time PCR","volume":"19","author":"Kang","year":"2018","journal-title":"BMC Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib44","article-title":"Prevalence of cancer-related fatigue based on severity: a systematic review and meta-analysis","volume":"13","author":"Kang","year":"2023","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2026.101262_bib45","doi-asserted-by":"crossref","DOI":"10.1016\/j.breast.2026.104700","article-title":"The trajectory of fatigue over time in breast cancer patients treated with chemotherapy: exploring the effect of anthracycline-based chemotherapy","volume":"85","author":"Kastelein","year":"2026","journal-title":"Breast"},{"key":"10.1016\/j.bbih.2026.101262_bib46","doi-asserted-by":"crossref","unstructured":"Kim, D. W., Byun J. M., Lee, J., et al. Chemotherapy delivery time affects treatment outcomes of female patients with diffuse large B cell lymphoma. (2023 Jan). JCI Insight, 8(2), e164767. https:\/\/doi.org\/10.1172\/jci.insight.164767.","DOI":"10.1172\/jci.insight.164767"},{"key":"10.1016\/j.bbih.2026.101262_bib47","doi-asserted-by":"crossref","DOI":"10.1016\/j.taap.2022.115863","article-title":"Circadian disruption and cisplatin chronotherapy for mammary carcinoma","volume":"436","author":"Koritala","year":"2022","journal-title":"Toxicol. Appl. Pharmacol."},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib48","doi-asserted-by":"crossref","first-page":"2705","DOI":"10.1038\/s41598-022-25322-y","article-title":"Four-year follow-up on fatigue and sleep quality of a three-armed partly randomized controlled study in breast cancer survivors with cancer-related fatigue","volume":"13","author":"Kr\u00f6z","year":"2023","journal-title":"Sci. Rep."},{"issue":"5","key":"10.1016\/j.bbih.2026.101262_bib49","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1111\/j.1349-7006.1990.tb02591.x","article-title":"Tumor growth rate and prognosis of breast cancer mainly detected by mass screening","volume":"81","author":"Kuroishi","year":"1990","journal-title":"Jpn. J. Cancer Res."},{"issue":"9","key":"10.1016\/j.bbih.2026.101262_bib50","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1016\/j.chembiol.2023.08.014","article-title":"Metabolic and chemical architecture of the mammalian circadian clock","volume":"30","author":"Laothamatas","year":"2023","journal-title":"Cell Chem. Biol."},{"issue":"10","key":"10.1016\/j.bbih.2026.101262_bib57","doi-asserted-by":"crossref","first-page":"1738","DOI":"10.1158\/2767-9764.CRC-25-0240","article-title":"Immune activation signatures associated with fatigue in cancer patients undergoing immune checkpoint inhibitor therapy","volume":"5","author":"Li","year":"2025","journal-title":"Cancer Res. Commun."},{"issue":"3","key":"10.1016\/j.bbih.2026.101262_bib56","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1007\/s00280-015-2804-x","article-title":"Cisplatin-based chronotherapy for advanced non-small cell lung cancer patients: a randomized controlled study and its pharmacokinetics analysis","volume":"76","author":"Li","year":"2015","journal-title":"Cancer Chemother. Pharmacol."},{"key":"10.1016\/j.bbih.2026.101262_bib58","doi-asserted-by":"crossref","DOI":"10.1177\/1534735419855134","article-title":"Influence of yoga on cancer-related fatigue and on mediational relationships between changes in sleep and cancer-related fatigue: a nationwide, multicenter randomized controlled trial of yoga in cancer survivors","volume":"18","author":"Lin","year":"2019","journal-title":"Integr. Cancer Ther."},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib51","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1200\/JCO.1990.8.4.705","article-title":"Chemotherapy of advanced ovarian cancer with 4'-O-tetrahydropyranyl doxorubicin and cisplatin: a randomized phase II trial with an evaluation of circadian timing and dose-intensity","volume":"8","author":"L\u00e9vi","year":"1990","journal-title":"J. Clin. Oncol."},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib52","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1002\/1097-0142(19920215)69:4<893::AID-CNCR2820690410>3.0.CO;2-X","article-title":"A chronopharmacologic phase II clinical trial with 5\u2010fluorouracil, folinic acid, and oxaliplatin using an ambulatory multichannel programmable pump. High antitumor effectiveness against metastatic colorectal cancer","volume":"69","author":"L\u00e9vi","year":"1992","journal-title":"Cancer"},{"issue":"9079","key":"10.1016\/j.bbih.2026.101262_bib54","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1016\/S0140-6736(97)03358-8","article-title":"Randomised multicentre trial of chronotherapy with oxaliplatin, fluorouracil, and folinic acid in metastatic colorectal cancer. International Organization for Cancer Chronotherapy","volume":"350","author":"L\u00e9vi","year":"1997","journal-title":"Lancet."},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1146\/annurev-pharmtox-051920-095416","article-title":"Circadian regulation of drug responses: toward sex-specific and personalized chronotherapy","volume":"64","author":"L\u00e9vi","year":"2024","journal-title":"Annu. Rev. Pharmacol. Toxicol."},{"issue":"21","key":"10.1016\/j.bbih.2026.101262_bib53","doi-asserted-by":"crossref","first-page":"1608","DOI":"10.1093\/jnci\/86.21.1608","article-title":"Chronomodulated versus fixed-infusion\u2014Rate delivery of ambulatory chemotherapy with oxaliplatin, fluorouracil, and folinic acid (leucovorin) in patients with colorectal cancer metastases: a randomized multi-institutional trial","volume":"86","author":"L\u00e9vi","year":"1994","journal-title":"J Natl Cancer Inst"},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib59","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1002\/cncr.21234","article-title":"Cognitive impairment, fatigue, and cytokine levels in patients with acute myelogenous leukemia or myelodysplastic syndrome","volume":"104","author":"Meyers","year":"2005","journal-title":"Cancer"},{"issue":"9","key":"10.1016\/j.bbih.2026.101262_bib60","doi-asserted-by":"crossref","first-page":"3342","DOI":"10.1073\/pnas.0611724104","article-title":"Circadian and CLOCK-controlled regulation of the mouse transcriptome and cell proliferation","volume":"104","author":"Miller","year":"2007","journal-title":"Proc Natl Acad Sci U S A."},{"issue":"5","key":"10.1016\/j.bbih.2026.101262_bib61","doi-asserted-by":"crossref","DOI":"10.1172\/jci.insight.126190","article-title":"The motivation for exercise over palatable food is dictated by cannabinoid type-1 receptors","volume":"4","author":"Muguruza","year":"2019","journal-title":"JCI Insight"},{"issue":"7","key":"10.1016\/j.bbih.2026.101262_bib62","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1001\/jamaoncol.2016.6914","article-title":"Comparison of treatments for cancer-related fatigue","volume":"3","author":"Mustian","year":"2017","journal-title":"JAMA Oncol."},{"key":"10.1016\/j.bbih.2026.101262_bib63","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.bbi.2014.07.013","article-title":"Tumor growth increases neuroinflammation, fatigue and depressive-like behavior prior to alterations in muscle function","volume":"43","author":"Norden","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"10","key":"10.1016\/j.bbih.2026.101262_bib64","doi-asserted-by":"crossref","first-page":"2168","DOI":"10.3390\/ijms18102168","article-title":"Molecular aspects of circadian pharmacology and relevance for cancer chronotherapy","volume":"18","author":"Ozturk","year":"2017","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbih.2026.101262_bib65","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1016\/j.bbi.2024.01.014","article-title":"The fatigue-inducing effects of cancer and its therapy are characterized by decreased physical activity in the absence of any motivational deficit","volume":"117","author":"Phan","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib66","first-page":"235","article-title":"Phase III study of mitomycin-c with protracted venous infusion or circadian-timed infusion of 5-fluorouracil in advanced colorectal carcinoma","volume":"3","author":"Price","year":"2004","journal-title":"Clin. Colorectal Cancer"},{"issue":"5","key":"10.1016\/j.bbih.2026.101262_bib67","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.neuron.2020.09.002","article-title":"Neuronal activity regulates blood-brain barrier efflux transport through endothelial circadian genes","volume":"108","author":"Pulido","year":"2020","journal-title":"Neuron"},{"issue":"2","key":"10.1016\/j.bbih.2026.101262_bib68","first-page":"119","article-title":"Development of a mouse model for assessing fatigue during chemotherapy","volume":"61","author":"Ray","year":"2011","journal-title":"Comp. Med."},{"issue":"3","key":"10.1016\/j.bbih.2026.101262_bib69","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1096\/fj.07-9574LSF","article-title":"Dose translation from animal to human studies revisited","volume":"22","author":"Reagan-Shaw","year":"2008","journal-title":"FASEB J."},{"issue":"3","key":"10.1016\/j.bbih.2026.101262_bib70","doi-asserted-by":"crossref","first-page":"201","DOI":"10.3109\/07420529309073888","article-title":"Circadian time-dependent response of childhood lymphoblastic leukemia to chemotherapy: a long-term follow-up study of survival","volume":"10","author":"Rivard","year":"1993","journal-title":"Chronobiol Intl"},{"issue":"6","key":"10.1016\/j.bbih.2026.101262_bib72","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.3390\/cancers16061087","article-title":"Retrospective observational study to determine the epidemiology and treatment patterns of patients with triple-negative breast cancer","volume":"16","author":"Rosi\u0144ska","year":"2024","journal-title":"Cancers (Basel)"},{"issue":"6","key":"10.1016\/j.bbih.2026.101262_bib73","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1002\/ijc.34791","article-title":"Cancer-related fatigue: towards a more targeted approach based on classification by biomarkers and psychological factors","volume":"154","author":"Schmidt","year":"2024","journal-title":"Int. J. Cancer"},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib74","first-page":"413","article-title":"The association between fatigue and inflammatory marker levels in cancer patients: a quantitative review","volume":"21","author":"Schubert","year":"2007","journal-title":"BBI"},{"issue":"9","key":"10.1016\/j.bbih.2026.101262_bib76","first-page":"4277","article-title":"Comparison of clinical efficacy between chrono-chemotherapy and conventional chemotherapy in patients with non-small cell lung cancer","volume":"13","author":"Shang","year":"2023","journal-title":"Am. J. Cancer Res."},{"key":"10.1016\/j.bbih.2026.101262_bib77","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2024.1446321","article-title":"Genes of cancer-related fatigue: a scoping review","volume":"14","author":"Song","year":"2024","journal-title":"Front. Oncol."},{"issue":"16","key":"10.1016\/j.bbih.2026.101262_bib78","doi-asserted-by":"crossref","first-page":"4630","DOI":"10.1002\/hbm.25146","article-title":"Causal role of lateral prefrontal cortex in mental effort and fatigue","volume":"41","author":"Soutschek","year":"2020","journal-title":"Hum. Brain Mapp."},{"issue":"8","key":"10.1016\/j.bbih.2026.101262_bib79","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1016\/j.trecan.2019.07.002","article-title":"Interplay between circadian clock and cancer: new frontiers for cancer treatment","volume":"5","author":"Sulli","year":"2019","journal-title":"Trends Cancer"},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib80","doi-asserted-by":"crossref","DOI":"10.1038\/srep42323","article-title":"Modified forelimb grip strength test detects aging-associated physiological decline in skeletal muscle function in male mice","volume":"7","author":"Takeshita","year":"2017","journal-title":"Sci. Rep."},{"key":"10.1016\/j.bbih.2026.101262_bib81","article-title":"Survival feature and trend of female breast cancer: a comprehensive review of survival analysis from cancer registration data","volume":"79","author":"Tang","year":"2024","journal-title":"Breast"},{"issue":"9","key":"10.1016\/j.bbih.2026.101262_bib82","doi-asserted-by":"crossref","DOI":"10.1523\/ENEURO.0061-25.2025","article-title":"Paclitaxel chemotherapy disrupts circadian gene transcription and function of the suprachiasmatic nuclei in female mice","volume":"12","author":"Tapp","year":"2025","journal-title":"eNeuro"},{"issue":"6","key":"10.1016\/j.bbih.2026.101262_bib84","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1038\/s41416-025-03116-z","article-title":"Fatigue in long-term cancer survivors: prevalence, associated factors, and mortality. A prospective population-based study","volume":"133","author":"Thong","year":"2025","journal-title":"Br. J. Cancer"},{"issue":"2","key":"10.1016\/j.bbih.2026.101262_bib83","doi-asserted-by":"crossref","DOI":"10.1007\/s11864-020-0707-5","article-title":"Cancer-related fatigue: causes and current treatment options","volume":"21","author":"Thong","year":"2020","journal-title":"Curr. Treat. Options Oncol."},{"issue":"9","key":"10.1016\/j.bbih.2026.101262_bib85","first-page":"676","article-title":"Sept). Phase II clinical study of different induction chemotherapy administration methods for nasopharyngeal carcinoma","volume":"37","author":"Ting","year":"2015","journal-title":"Chin. J. Oncol."},{"issue":"2","key":"10.1016\/j.bbih.2026.101262_bib86","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1093\/gerona\/glt023","article-title":"Simple biological informed inflammatory index of two serum cytokines predicts 10 year all-cause mortality in older adults","volume":"69A","author":"Varadhan","year":"2013","journal-title":"J Gerontol A Biol Sci Med Sci"},{"issue":"11","key":"10.1016\/j.bbih.2026.101262_bib71","doi-asserted-by":"crossref","first-page":"1710","DOI":"10.1200\/JCO.1989.7.11.1710","article-title":"Circadian patterning of continuous floxuridine infusion reduces toxicity and allows higher dose intensity in patients with widespread cancer","volume":"7","author":"von Roemeling","year":"1989","journal-title":"J. Clin. Oncol."},{"key":"10.1016\/j.bbih.2026.101262_bib87","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.bbi.2020.07.032","article-title":"Social enrichment attenuates chemotherapy induced pro-inflammatory cytokine production and affective behavior via oxytocin signaling","volume":"89","author":"Walker II","year":"2020","journal-title":"Brain Behav. Immun."},{"issue":"4","key":"10.1016\/j.bbih.2026.101262_bib89","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1080\/07420528.2021.2011306","article-title":"Time-restricted feeding alters the efficiency of mammary tumor growth","volume":"39","author":"Walker II","year":"2022","journal-title":"Chronobiol. Int."},{"key":"10.1016\/j.bbih.2026.101262_bib88","doi-asserted-by":"crossref","DOI":"10.3389\/fonc.2021.752331","article-title":"Circadian influences on chemotherapy efficacy in a mouse model of brain metastases of breast cancer","volume":"11","author":"Walker II","year":"2021","journal-title":"Front. Oncol."},{"key":"10.1016\/j.bbih.2026.101262_bib91","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/j.bbi.2023.11.020","article-title":"Internal circadian misallignment in a mouse model of chemotherapy induced fatigue","volume":"115","author":"Wang","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"10","key":"10.1016\/j.bbih.2026.101262_bib90","doi-asserted-by":"crossref","DOI":"10.3390\/cancers14102421","article-title":"Induction of fatiuge by specific anthracycline cancer drugs through disruption of the circadian pacemaker","volume":"14","author":"Wang","year":"2022","journal-title":"Cancers"},{"key":"10.1016\/j.bbih.2026.101262_bib92","doi-asserted-by":"crossref","DOI":"10.3389\/fnbeh.2025.1678147","article-title":"Novel behavioral tasks for the measurement of social motivation in mice: a comparison across strains","volume":"19","author":"Wells","year":"2026","journal-title":"Front. Behav. Neurosci."},{"key":"10.1016\/j.bbih.2026.101262_bib93","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.bbi.2013.11.003","article-title":"A role for orexin in cytotoxic chemotherapy-induced fatigue","volume":"37","author":"Weymann","year":"2014","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib94","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-32654-1","article-title":"Comparing passive measures of fatigue-like behavior in mice","volume":"8","author":"Wolff","year":"2018","journal-title":"Sci. Rep."},{"issue":"69","key":"10.1016\/j.bbih.2026.101262_bib99","article-title":"SARS-CoV-2 infection induces a long-lived pro-inflammatory transcriptional profile","volume":"15","author":"Zhang","year":"2023","journal-title":"Genome Med."},{"issue":"45","key":"10.1016\/j.bbih.2026.101262_bib95","doi-asserted-by":"crossref","first-page":"16219","DOI":"10.1073\/pnas.1408886111","article-title":"A circadian gene expression atlas in mammals: implications for biology and medicine","volume":"111","author":"Zhang","year":"2014","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib97","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1038\/s41467-020-20795-9","article-title":"A circadian clock regulates efflux by the blood-brain barrier in mice and human cells","volume":"12","author":"Zhang","year":"2021","journal-title":"Nat. Commun."},{"issue":"1","key":"10.1016\/j.bbih.2026.101262_bib96","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.cell.2018.02.017","article-title":"A circadian clock in the blood-brain barrier regulates xenobiotic efflux","volume":"173","author":"Zhang","year":"2018","journal-title":"Cell"},{"key":"10.1016\/j.bbih.2026.101262_bib98","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbr.2022.113981","article-title":"A spatiotemporal increase of neuronal activity accompanies the motivational effect of wheel running in mice","volume":"432","author":"Zhang","year":"2022","journal-title":"Behav. Brain Res."},{"key":"10.1016\/j.bbih.2026.101262_bib100","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.1016\/j.biopha.2019.01.042","article-title":"ShenQi FuZheng injection ameliorates fatigue-like behavior in mouse models of cancer-related fatigue","volume":"111","author":"Zhu","year":"2019","journal-title":"Biomed. Pharmacother."},{"issue":"6","key":"10.1016\/j.bbih.2026.101262_bib101","first-page":"491","article-title":"A clinically translatable mouse model for chemotherapy-related fatigue","volume":"63","author":"Zombeck","year":"2013","journal-title":"Comp. Med."}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626000955?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626000955?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,4]],"date-time":"2026-07-04T01:10:32Z","timestamp":1783127432000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354626000955"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7]]},"references-count":100,"alternative-id":["S2666354626000955"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101262","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,7]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Chronotherapeutic administration of neoadjuvant chemotherapy reduces cancer-related fatigue-like behavior","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101262","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101262"}}