{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:11:50Z","timestamp":1783973510446,"version":"3.55.0"},"reference-count":58,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,8,1]],"date-time":"2026-08-01T00:00:00Z","timestamp":1785542400000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T00:00:00Z","timestamp":1781913600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, &amp; Immunity - Health"],"published-print":{"date-parts":[[2026,8]]},"DOI":"10.1016\/j.bbih.2026.101289","type":"journal-article","created":{"date-parts":[[2026,6,20]],"date-time":"2026-06-20T15:15:43Z","timestamp":1781968543000},"page":"101289","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["PCSK9 at the intersection of lipid metabolism, immunometabolism, and psychiatric disorders: A narrative review"],"prefix":"10.1016","volume":"55","author":[{"given":"Folkert H.","family":"van Bruggen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Roger S.","family":"McIntyre","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"issue":"9","key":"10.1016\/j.bbih.2026.101289_bib1","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0310396","article-title":"Investigating the association of the effect of genetically proxied PCSK9i with mood disorders using cis-pQTLs: a drug-target Mendelian randomization study","volume":"19","author":"Aman","year":"2024","journal-title":"PLoS One"},{"issue":"2","key":"10.1016\/j.bbih.2026.101289_bib2","doi-asserted-by":"crossref","DOI":"10.1161\/JAHA.118.010838","article-title":"Pretreatment with PCSK9 inhibitor protects the brain against cardiac ischemia\/Reperfusion Injury through a reduction of neuronal inflammation and amyloid beta aggregation","volume":"8","author":"Apaijai","year":"2019","journal-title":"J. Am. Heart Assoc."},{"key":"10.1016\/j.bbih.2026.101289_bib3","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1155\/2017\/8356537","article-title":"The LDL receptor-related protein 1: at the crossroads of lipoprotein metabolism and insulin signaling","volume":"2017","author":"Au","year":"2017","journal-title":"J. Diabetes Res."},{"key":"10.1016\/j.bbih.2026.101289_bib4","doi-asserted-by":"crossref","DOI":"10.1016\/j.neubiorev.2023.105155","article-title":"Proprotein convertase subtilisin\/kexin type 9 (PCSK9) in the central nervous system","volume":"149","author":"Bell","year":"2023","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbih.2026.101289_bib5","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2022.847310","article-title":"A systematic review and meta-analysis of lipid signatures in post-traumatic stress disorder","volume":"13","author":"Bharti","year":"2022","journal-title":"Front. Psychiatr."},{"key":"10.1016\/j.bbih.2026.101289_bib6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.jpsychires.2021.05.036","article-title":"A systematic review and meta-analysis of lipid metabolomic signatures of major depressive disorder","volume":"139","author":"Bharti","year":"2021","journal-title":"J. Psychiatr. Res."},{"key":"10.1016\/j.bbih.2026.101289_bib7","doi-asserted-by":"crossref","first-page":"1667","DOI":"10.2147\/NDT.S480921","article-title":"Lack of efficacy of Simvastatin adjunctive therapy for patients with schizophrenia: a meta-analysis of randomized controlled trials","volume":"20","author":"Chen","year":"2024","journal-title":"Neuropsychiatric Dis. Treat."},{"issue":"5","key":"10.1016\/j.bbih.2026.101289_bib8","doi-asserted-by":"crossref","first-page":"445","DOI":"10.1007\/s11745-014-3895-6","article-title":"PCSK9 is present in human cerebrospinal fluid and is maintained at remarkably constant concentrations throughout the course of the day","volume":"49","author":"Chen","year":"2014","journal-title":"Lipids"},{"key":"10.1016\/j.bbih.2026.101289_bib9","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1016\/j.jad.2022.05.113","article-title":"The effects of Statin monotherapy on depressive symptoms: a systematic review and meta-analysis","volume":"311","author":"De Giorgi","year":"2022","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbih.2026.101289_bib10","article-title":"Cholesterol metabolism and oxysterols in neurodegenerative disorders: spotlight on Alzheimer's disease","volume":"41","author":"Delac","year":"2025","journal-title":"Curr. Opin. Endocr. Metab. Res."},{"issue":"3","key":"10.1016\/j.bbih.2026.101289_bib11","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1007\/s40264-020-01021-3","article-title":"PCSK9 inhibitors and neurocognitive adverse drug reactions: analysis of individual case safety reports from the eudravigilance database","volume":"44","author":"di Mauro","year":"2021","journal-title":"Drug Saf."},{"issue":"2","key":"10.1016\/j.bbih.2026.101289_bib12","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1007\/s10557-021-07242-7","article-title":"Neurocognitive disorders associated with PCSK9 inhibitors: a pharmacovigilance disproportionality analysis","volume":"37","author":"Gouverneur","year":"2023","journal-title":"Cardiovasc. Drugs Ther."},{"key":"10.1016\/j.bbih.2026.101289_bib13","doi-asserted-by":"crossref","DOI":"10.3389\/fnagi.2021.685594","article-title":"The cerebrospinal fluid profile of cholesterol metabolites in parkinson's disease and their association with disease state and clinical features","volume":"13","author":"Griffiths","year":"2021","journal-title":"Front. Aging Neurosci."},{"issue":"4","key":"10.1016\/j.bbih.2026.101289_bib14","doi-asserted-by":"crossref","first-page":"519","DOI":"10.32598\/bcn.2022.4044.1","article-title":"The PCSK9 protein is not necessarily a risk factor for major depressive disorder","volume":"15","author":"Habibitabar","year":"2024","journal-title":"Basic and Clinical Neuroscience Journal"},{"issue":"3","key":"10.1016\/j.bbih.2026.101289_bib15","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1161\/CIRCULATIONAHA.123.064498","article-title":"PCSK9: from nature's loss to patient's gain","volume":"149","author":"Hobbs","year":"2024","journal-title":"Circulation"},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib16","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1007\/s00213-021-06042-z","article-title":"PCSK9 mediates dyslipidemia induced by olanzapine treatment in schizophrenia patients","volume":"239","author":"Huang","year":"2022","journal-title":"Psychopharmacology"},{"issue":"4","key":"10.1016\/j.bbih.2026.101289_bib17","doi-asserted-by":"crossref","DOI":"10.1096\/fj.202301748R","article-title":"<scp>PCSK9<\/scp> dysregulates cholesterol homeostasis and triglyceride metabolism in olanzapine\u2010induced hepatic steatosis via both receptor\u2010dependent and receptor\u2010independent pathways","volume":"38","author":"Huang","year":"2024","journal-title":"FASEB J."},{"issue":"9","key":"10.1016\/j.bbih.2026.101289_bib18","doi-asserted-by":"crossref","DOI":"10.1016\/j.jlr.2023.100426","article-title":"PCSK9 and the nervous system: a no-brainer?","volume":"64","author":"Jaafar","year":"2023","journal-title":"Journal of Lipid Research"},{"issue":"12","key":"10.1016\/j.bbih.2026.101289_bib19","doi-asserted-by":"crossref","first-page":"2515","DOI":"10.1194\/jlr.R026658","article-title":"The PCSK9 decade","volume":"53","author":"Lambert","year":"2012","journal-title":"Journal of Lipid Research"},{"issue":"6","key":"10.1016\/j.bbih.2026.101289_bib20","doi-asserted-by":"crossref","first-page":"1163","DOI":"10.1111\/acer.14039","article-title":"PCSK9 is increased in cerebrospinal fluid of individuals with alcohol use disorder","volume":"43","author":"Lee","year":"2019","journal-title":"Alcohol Clin. Exp. Res."},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib21","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1007\/s11064-024-04272-z","article-title":"Inhibition of PCSK9 protects against cerebral ischemia\u2012reperfusion injury via attenuating microcirculatory dysfunction","volume":"50","author":"Luo","year":"2025","journal-title":"Neurochem. Res."},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib22","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1186\/s12933-020-01158-6","article-title":"Depression and cardiovascular Risk\u2014Association among beck depression inventory, PCSK9 levels and insulin resistance","volume":"19","author":"Macchi","year":"2020","journal-title":"Cardiovasc. Diabetol."},{"issue":"7","key":"10.1016\/j.bbih.2026.101289_bib23","doi-asserted-by":"crossref","first-page":"1305","DOI":"10.1161\/ATVBAHA.116.307023","article-title":"Central nervous system lipoproteins","volume":"36","author":"Mahley","year":"2016","journal-title":"Arterioscler. Thromb. Vasc. Biol."},{"key":"10.1016\/j.bbih.2026.101289_bib24","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1016\/j.jpsychires.2020.12.007","article-title":"Exploring brain insulin resistance in adults with bipolar depression using extracellular vesicles of neuronal origin","volume":"133","author":"Mansur","year":"2021","journal-title":"J. Psychiatr. Res."},{"issue":"10","key":"10.1016\/j.bbih.2026.101289_bib25","doi-asserted-by":"crossref","first-page":"885","DOI":"10.1176\/appi.ajp.2021.21080814","article-title":"Surrogate markers of insulin resistance in predicting major depressive disorder: metabolism metastasizes to the brain","volume":"178","author":"McIntyre","year":"2021","journal-title":"Am. J. Psychiatr."},{"key":"10.1016\/j.bbih.2026.101289_bib26","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2025.107660","article-title":"Sex-dependent behavioral responses and phenotypic traits of Pcsk9 knockout mice in anxiety- and depression-like paradigms","volume":"183","author":"Nasini","year":"2026","journal-title":"Psychoneuroendocrinology"},{"key":"10.1016\/j.bbih.2026.101289_bib27","article-title":"Proprotein convertase subtilisin\/Kexin type 9 (PCSK9) in the brain and relevance for neuropsychiatric disorders","volume":"14","author":"O'Connell","year":"2020","journal-title":"Front. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib28","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1177\/13872877241284213","article-title":"Influence of APOE4 genotype on PCSK9-lipids association in cerebrospinal fluid and serum of patients in the Alzheimer's disease continuum","volume":"102","author":"Papotti","year":"2024","journal-title":"J. Alzheimers Dis."},{"key":"10.1016\/j.bbih.2026.101289_bib30","doi-asserted-by":"crossref","DOI":"10.1016\/j.phrs.2025.107652","article-title":"Neuronal PCSK9 regulates cognitive performances via the modulation of ApoER2 synaptic localization","volume":"213","author":"Pelucchi","year":"2025","journal-title":"Pharmacol. Res."},{"key":"10.1016\/j.bbih.2026.101289_bib31","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.genhosppsych.2024.05.001","article-title":"Statins as an adjuvant therapy for patients with schizophrenia: an up-to-date systematic review and meta-analysis","volume":"89","author":"Peng","year":"2024","journal-title":"Gen. Hosp. Psychiatry"},{"key":"10.1016\/j.bbih.2026.101289_bib32","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.jad.2016.07.033","article-title":"Depression and serum low-density lipoprotein: a systematic review and meta-analysis","volume":"206","author":"Persons","year":"2016","journal-title":"J. Affect. Disord."},{"issue":"2","key":"10.1016\/j.bbih.2026.101289_bib33","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0005-2736(03)00024-5","article-title":"Role of cholesterol in synapse formation and function","volume":"1610","author":"Pfrieger","year":"2003","journal-title":"Biochimica et Biophysica Acta (BBA) - Biomembranes"},{"issue":"4","key":"10.1016\/j.bbih.2026.101289_bib34","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1016\/j.plipres.2011.06.002","article-title":"Cholesterol metabolism in neurons and astrocytes","volume":"50","author":"Pfrieger","year":"2011","journal-title":"Prog. Lipid Res."},{"issue":"8","key":"10.1016\/j.bbih.2026.101289_bib35","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0220254","article-title":"Proprotein convertase subtilisin\/kexin type 9 (PCSK9) in Alzheimer's disease: a genetic and proteomic multi-cohort study","volume":"14","author":"Picard","year":"2019","journal-title":"PLoS One"},{"issue":"6","key":"10.1016\/j.bbih.2026.101289_bib36","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1192\/bjp.bp.117.200907","article-title":"Cholesterol and triglyceride levels in first-episode psychosis: systematic review and meta-analysis","volume":"211","author":"Pillinger","year":"2017","journal-title":"Br. J. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib37","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1016\/S2215-0366(19)30416-X","article-title":"Comparative effects of 18 antipsychotics on metabolic function in patients with schizophrenia, predictors of metabolic dysregulation, and association with psychopathology: a systematic review and network meta-analysis","volume":"7","author":"Pillinger","year":"2020","journal-title":"Lancet Psychiatry"},{"key":"10.1016\/j.bbih.2026.101289_bib29","doi-asserted-by":"crossref","DOI":"10.3389\/fnmol.2022.1084633","article-title":"PCSK9 deficiency alters brain lipid composition without affecting brain development and function","volume":"15","author":"P\u00e4rn","year":"2023","journal-title":"Front. Mol. Neurosci."},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib38","doi-asserted-by":"crossref","first-page":"2267","DOI":"10.1038\/s41598-018-20425-x","article-title":"PCSK9 induces a pro-inflammatory response in macrophages","volume":"8","author":"Ricci","year":"2018","journal-title":"Sci. Rep."},{"issue":"11","key":"10.1016\/j.bbih.2026.101289_bib39","doi-asserted-by":"crossref","first-page":"1042","DOI":"10.1111\/dom.12536","article-title":"Effect of statin therapy on plasma proprotein convertase subtilisin kexin 9 (<scp>PCSK9<\/scp>) concentrations: a systematic review and meta\u2010analysis of clinical trials","volume":"17","author":"Sahebkar","year":"2015","journal-title":"Diabetes Obes. Metabol."},{"issue":"23","key":"10.1016\/j.bbih.2026.101289_bib40","doi-asserted-by":"crossref","DOI":"10.3390\/ijms222312640","article-title":"PCSK9 induces tissue factor expression by activation of TLR4\/NFkB signaling","volume":"22","author":"Scalise","year":"2021","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib41","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.biopsych.2004.03.019","article-title":"Altered thalamic membrane phospholipids in schizophrenia: a postmortem study","volume":"56","author":"Schmitt","year":"2004","journal-title":"Biol. Psychiatry"},{"issue":"10","key":"10.1016\/j.bbih.2026.101289_bib42","doi-asserted-by":"crossref","first-page":"4266","DOI":"10.1021\/pr800188y","article-title":"High throughput lipidomic profiling of schizophrenia and bipolar disorder brain tissue reveals alterations of free fatty acids, phosphatidylcholines, and ceramides","volume":"7","author":"Schwarz","year":"2008","journal-title":"J. Proteome Res."},{"issue":"5","key":"10.1016\/j.bbih.2026.101289_bib43","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/nrd3699","article-title":"The biology and therapeutic targeting of the proprotein convertases","volume":"11","author":"Seidah","year":"2012","journal-title":"Nat. Rev. Drug Discov."},{"key":"10.1016\/j.bbih.2026.101289_bib44","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.psychres.2018.02.018","article-title":"Adjunctive therapy with statins in schizophrenia patients: a meta-analysis and implications","volume":"262","author":"Shen","year":"2018","journal-title":"Psychiatry Res."},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib45","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1007\/s12160-008-9045-8","article-title":"Are cholesterol and depression inversely related? A meta-analysis of the association between two cardiac risk factors","volume":"36","author":"Shin","year":"2008","journal-title":"Ann. Behav. Med."},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib46","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1186\/s12987-020-00196-2","article-title":"Choroid plexus and the blood\u2013cerebrospinal fluid barrier in disease","volume":"17","author":"Sol\u00e1r","year":"2020","journal-title":"Fluids Barriers CNS"},{"issue":"4","key":"10.1016\/j.bbih.2026.101289_bib47","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.bpsgos.2023.01.004","article-title":"Tissue-specific oxysterols as predictors of antidepressant (Escitalopram) treatment response in patients with major depressive disorder","volume":"3","author":"Sun","year":"2023","journal-title":"Biological Psychiatry Global Open Science"},{"key":"10.1016\/j.bbih.2026.101289_bib48","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2021.711734","article-title":"Brain-specific oxysterols and risk of schizophrenia in clinical high-risk subjects and patients with schizophrenia","volume":"12","author":"Sun","year":"2021","journal-title":"Front. Psychiatr."},{"issue":"Jul 13","key":"10.1016\/j.bbih.2026.101289_bib50","doi-asserted-by":"crossref","first-page":"787","DOI":"10.1080\/17512433.2020.1787832","article-title":"Serious adverse events and deaths in PCSK9 inhibitor trials reported on ClinicalTrials.gov: a systematic review","author":"van Bruggen","year":"2020","journal-title":"Expert Rev. Clin. Pharmacol."},{"key":"10.1016\/j.bbih.2026.101289_bib49","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbih.2025.101166","article-title":"Neuroinflammation and insulin resistance in major depression and bipolar disorder: implications for clinical trials evaluating immunometabolic targeted therapies","volume":"51","author":"van Bruggen","year":"2026","journal-title":"Brain, Behavior, & Immunity - Health"},{"issue":"2","key":"10.1016\/j.bbih.2026.101289_bib51","doi-asserted-by":"crossref","DOI":"10.1016\/j.diabet.2021.101284","article-title":"Liraglutide reduces plasma PCSK9 in patients with type 2 diabetes not treated with statins","volume":"48","author":"Verg\u00e8s","year":"2022","journal-title":"Diabetes Metabol."},{"key":"10.1016\/j.bbih.2026.101289_bib52","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1016\/j.bbi.2023.11.008","article-title":"PCSK9 ablation attenuates A\u03b2 pathology, neuroinflammation and cognitive dysfunctions in 5XFAD mice","volume":"115","author":"Vilella","year":"2024","journal-title":"Brain Behav. Immun."},{"issue":"12","key":"10.1016\/j.bbih.2026.101289_bib53","doi-asserted-by":"crossref","first-page":"2884","DOI":"10.3390\/biomedicines12122884","article-title":"Discordance between triglycerides, remnant cholesterol and systemic inflammation in patients with schizophrenia","volume":"12","author":"Wang","year":"2024","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbih.2026.101289_bib54","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyt.2023.1203444","article-title":"Statin for mood and inflammation among adult patients with major depressive disorder: an updated meta-analysis","volume":"14","author":"Xiao","year":"2023","journal-title":"Front. Psychiatr."},{"issue":"10","key":"10.1016\/j.bbih.2026.101289_bib55","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0311625","article-title":"Association between triglyceride and depression: a systematic review and meta-analysis","volume":"19","author":"Xu","year":"2024","journal-title":"PLoS One"},{"key":"10.1016\/j.bbih.2026.101289_bib56","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbih.2022.100441","article-title":"Blood-brain barrier dysfunction in bipolar disorder: molecular mechanisms and clinical implications","volume":"21","author":"Zhao","year":"2022","journal-title":"Brain, Behavior, & Immunity - Health"},{"key":"10.1016\/j.bbih.2026.101289_bib57","doi-asserted-by":"crossref","DOI":"10.1016\/j.intimp.2023.111195","article-title":"PCSK9 inhibitor protects against ischemic cerebral injury by attenuating inflammation via the GPNMB\/CD44 pathway","volume":"126","author":"Zheng","year":"2024","journal-title":"Int. Immunopharmacol."},{"issue":"1","key":"10.1016\/j.bbih.2026.101289_bib58","doi-asserted-by":"crossref","first-page":"5639","DOI":"10.1038\/s41598-022-09610-1","article-title":"Metformin ameliorates hepatic steatosis induced by olanzapine through inhibiting LXR\u03b1\/PCSK9 pathway","volume":"12","author":"Zhu","year":"2022","journal-title":"Sci. Rep."}],"container-title":["Brain, Behavior, &amp; Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001225?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001225?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,7,13]],"date-time":"2026-07-13T20:03:47Z","timestamp":1783973027000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354626001225"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,8]]},"references-count":58,"alternative-id":["S2666354626001225"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101289","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,8]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"PCSK9 at the intersection of lipid metabolism, immunometabolism, and psychiatric disorders: A narrative review","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101289","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101289"}}