{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T21:07:19Z","timestamp":1789160839496,"version":"build-2803163510"},"reference-count":170,"publisher":"Elsevier BV","license":[{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/tdm\/userlicense\/1.0\/"},{"start":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T00:00:00Z","timestamp":1790812800000},"content-version":"tdm","delay-in-days":0,"URL":"https:\/\/www.elsevier.com\/legal\/tdmrep-license"},{"start":{"date-parts":[[2026,7,5]],"date-time":"2026-07-05T00:00:00Z","timestamp":1783209600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003130","name":"Research Foundation Flanders","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100003130","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["clinicalkey.com","clinicalkey.com.au","clinicalkey.es","clinicalkey.fr","clinicalkey.jp","elsevier.com","sciencedirect.com"],"crossmark-restriction":true},"short-container-title":["Brain, Behavior, & Immunity - Health"],"published-print":{"date-parts":[[2026,10]]},"DOI":"10.1016\/j.bbih.2026.101299","type":"journal-article","created":{"date-parts":[[2026,7,6]],"date-time":"2026-07-06T15:33:48Z","timestamp":1783352028000},"page":"101299","update-policy":"https:\/\/doi.org\/10.1016\/elsevier_cm_policy","source":"Crossref","is-referenced-by-count":0,"special_numbering":"C","title":["Multimodal approach to identify neuropsychophysiological subgroups in myalgic encephalomyelitis\/chronic fatigue syndrome and their relevance for rehabilitation: protocol for a mechanistic cross-sectional and longitudinal study"],"prefix":"10.1016","volume":"56","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-6891-9686","authenticated-orcid":false,"given":"Ynse","family":"Dooms","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lixin","family":"Qiu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iris","family":"Coppieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elfi","family":"Vergaelen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephan","family":"Claes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patrick","family":"Dupont","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melina","family":"Hehl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Koen","family":"Cuypers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harald","family":"Engler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kirsten","family":"Dombrowski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristin","family":"Verbeke","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Omer","family":"Van den Bergh","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeroen","family":"Raes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lukas","family":"Van Oudenhove","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9432-0333","authenticated-orcid":false,"given":"Maaike","family":"Van Den Houte","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katleen","family":"Bogaerts","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"78","reference":[{"key":"10.1016\/j.bbih.2026.101299_bib1","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1016\/j.jad.2022.04.147","article-title":"General psychopathology and its social correlates in the daily lives of youth","volume":"309","author":"Achterhof","year":"2022","journal-title":"J. Affect. Disord."},{"issue":"10","key":"10.1016\/j.bbih.2026.101299_bib2","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1177\/0141076820951545","article-title":"Cognitive behavioural therapy for chronic fatigue and chronic fatigue syndrome: outcomes from a specialist clinic in the UK","volume":"113","author":"Adamson","year":"2020","journal-title":"J. R. Soc. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib3","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/j.bbi.2018.09.018","article-title":"Brain glial activation in fibromyalgia - a multi-site positron emission tomography investigation","volume":"75","author":"Albrecht","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib5","doi-asserted-by":"crossref","first-page":"864","DOI":"10.1038\/s41380-019-0433-1","article-title":"The neuroinflammatory component of negative affect in patients with chronic pain","volume":"26","author":"Albrecht","year":"2021","journal-title":"Mol. Psychiatr."},{"issue":"17","key":"10.1016\/j.bbih.2026.101299_bib4","doi-asserted-by":"crossref","first-page":"e2038","DOI":"10.1212\/WNL.0000000000007371","article-title":"Imaging of neuroinflammation in migraine with aura: a [(11)C]PBR28 PET\/MRI study","volume":"92","author":"Albrecht","year":"2019","journal-title":"Neurology"},{"issue":"8","key":"10.1016\/j.bbih.2026.101299_bib6","doi-asserted-by":"crossref","DOI":"10.1136\/bmjopen-2019-031672","article-title":"Using structural and functional MRI as a neuroimaging technique to investigate chronic fatigue syndrome\/myalgic encephalopathy: a systematic review","volume":"10","author":"Almutairi","year":"2020","journal-title":"BMJ Open"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib7","article-title":"A focus on the assessment of the autonomic function using heart rate variability","volume":"2025","author":"Amekran","year":"2025","journal-title":"Glob. Cardiol. Sci. Pract."},{"key":"10.1016\/j.bbih.2026.101299_bib8","doi-asserted-by":"crossref","DOI":"10.1016\/j.neuropharm.2021.108719","article-title":"Glutamate metabolism and recycling at the excitatory synapse in health and neurodegeneration","volume":"196","author":"Andersen","year":"2021","journal-title":"Neuropharmacology"},{"issue":"5","key":"10.1016\/j.bbih.2026.101299_bib9","doi-asserted-by":"crossref","first-page":"443","DOI":"10.1016\/j.molmed.2024.02.003","article-title":"Unravelling shared mechanisms: insights from recent ME\/CFS research to illuminate long COVID pathologies","volume":"30","author":"Annesley","year":"2024","journal-title":"Trends Mol. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib10","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1386607","article-title":"Myalgic Encephalomyelitis\/chronic fatigue syndrome: the biology of a neglected disease","volume":"15","author":"Arron","year":"2024","journal-title":"Front. Immunol."},{"issue":"5","key":"10.1016\/j.bbih.2026.101299_bib11","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.3390\/ijms26051896","article-title":"Cognitive dysfunction in myalgic encephalomyelitis\/chronic fatigue syndrome\u2014aetiology and potential treatments","volume":"26","author":"Bansal","year":"2025","journal-title":"Int. J. Mol. Sci."},{"key":"10.1016\/j.bbih.2026.101299_bib12","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1440643","article-title":"Meta-analysis of natural killer cell cytotoxicity in myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"15","author":"Baraniuk","year":"2024","journal-title":"Front. Immunol."},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib13","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1016\/S0165-1781(99)00081-5","article-title":"Quality of life in depression: daily life determinants and variability","volume":"88","author":"Barge-Schaapveld","year":"1999","journal-title":"Psychiatry Res."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib14","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s11307-017-1099-1","article-title":"Increased expression of translocator protein (TSPO) marks pro-inflammatory microglia but does not predict neurodegeneration","volume":"20","author":"Beckers","year":"2018","journal-title":"Mol. Imag. Biol."},{"key":"10.1016\/j.bbih.2026.101299_bib15","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini","year":"1995","journal-title":"J. Royal Statist. Soc. Serie. b-methodol."},{"issue":"8","key":"10.1016\/j.bbih.2026.101299_bib16","doi-asserted-by":"crossref","first-page":"1132","DOI":"10.1176\/ajp.151.8.1132","article-title":"Initial reliability and validity of a new retrospective measure of child abuse and neglect","volume":"151","author":"Bernstein","year":"1994","journal-title":"Am. J. Psychiatry"},{"key":"10.1016\/j.bbih.2026.101299_bib17","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.neubiorev.2021.01.001","article-title":"The brain under stress-A systematic review and activation likelihood estimation meta-analysis of changes in BOLD signal associated with acute stress exposure","volume":"124","author":"Berretz","year":"2021","journal-title":"Neurosci. Biobehav. Rev."},{"key":"10.1016\/j.bbih.2026.101299_bib18","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.bbi.2015.07.004","article-title":"Chronic fatigue syndrome and circulating cytokines: a systematic review","volume":"50","author":"Blundell","year":"2015","journal-title":"Brain Behav. Immun."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib19","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1038\/s41398-023-02567-3","article-title":"Brain mediators of negative affect-induced physical symptom reporting in patients with functional somatic syndromes","volume":"13","author":"Bogaerts","year":"2023","journal-title":"Transl. Psychiatry"},{"issue":"4","key":"10.1016\/j.bbih.2026.101299_bib20","doi-asserted-by":"crossref","first-page":"603","DOI":"10.1016\/j.mri.2015.12.008","article-title":"Abnormal resting state functional connectivity in patients with chronic fatigue syndrome: an arterial spin-labeling fMRI study","volume":"34","author":"Boissoneault","year":"2016","journal-title":"Magn. Reson. Imaging"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib21","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1111\/cpf.12393","article-title":"Static and dynamic functional connectivity in patients with chronic fatigue syndrome: use of arterial spin labelling fMRI","volume":"38","author":"Boissoneault","year":"2018","journal-title":"Clin. Physiol. Funct. Imag."},{"issue":"2","key":"10.1016\/j.bbih.2026.101299_bib22","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1016\/0165-1781(89)90047-4","article-title":"The Pittsburgh sleep quality index: a new instrument for psychiatric practice and research","volume":"28","author":"Buysse","year":"1989","journal-title":"Psychiatry Res."},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib23","doi-asserted-by":"crossref","first-page":"E197","DOI":"10.1503\/jpn.210124","article-title":"The functional and structural associations of aberrant microglial activity in major depressive disorder","volume":"47","author":"Cakmak","year":"2022","journal-title":"J. Psychiatry Neurosci."},{"key":"10.1016\/j.bbih.2026.101299_bib24","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1016\/B978-0-12-816386-3.00047-8","article-title":"PET imaging of neuroinflammation","author":"Chaney","year":"2021","journal-title":"Mol. Imaging"},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib25","doi-asserted-by":"crossref","first-page":"576","DOI":"10.1007\/s11481-013-9460-x","article-title":"Magnetic resonance spectroscopy to assess neuroinflammation and neuropathic pain","volume":"8","author":"Chang","year":"2013","journal-title":"J. Neuroimmune Pharmacol."},{"issue":"7","key":"10.1016\/j.bbih.2026.101299_bib26","doi-asserted-by":"crossref","first-page":"592","DOI":"10.2174\/1389203716666150630135720","article-title":"Interaction between microbes and host intestinal health: modulation by dietary nutrients and gut-brain-endocrine-immune axis","volume":"16","author":"Chen","year":"2015","journal-title":"Curr. Protein Pept. Sci."},{"issue":"4\u20135","key":"10.1016\/j.bbih.2026.101299_bib27","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1159\/000017321","article-title":"N-acetyl aspartate: a marker for neuronal loss or mitochondrial dysfunction","volume":"20","author":"Clark","year":"1998","journal-title":"Dev. Neurosci."},{"key":"10.1016\/j.bbih.2026.101299_bib29","unstructured":"Clarke W, Berrington A, Jbabdi S. FSL-MRS pipelines and fitting visualisation. https:\/\/pages.fmrib.ox.ac.uk\/fsl\/fsl_mrs_practicals\/marbel_meeting\/6_fitting_vis_pipelines.html (accessed 13 January 2026)."},{"key":"10.1016\/j.bbih.2026.101299_bib28","series-title":"Introduction to Magnetic Resonance Spectroscopy Acquisition and Analysis","first-page":"208","author":"Clarke","year":"2025"},{"key":"10.1016\/j.bbih.2026.101299_bib30","series-title":"The Social Psychology of Health","article-title":"Perceived stress in a probability sample of the United States","author":"Cohen","year":"1988"},{"key":"10.1016\/j.bbih.2026.101299_bib31","year":"2015"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib32","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1016\/j.neuroimage.2007.02.033","article-title":"Functional neuroimaging correlates of mental fatigue induced by cognition among chronic fatigue syndrome patients and controls","volume":"36","author":"Cook","year":"2007","journal-title":"Neuroimage"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib33","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1186\/s12883-019-1433-0","article-title":"A systematic review of cytokines in chronic fatigue syndrome\/myalgic encephalomyelitis\/systemic exertion intolerance disease (ME\/CFS\/SEID)","volume":"19","author":"Corbitt","year":"2019","journal-title":"BMC Neurol."},{"key":"10.1016\/j.bbih.2026.101299_bib34","doi-asserted-by":"crossref","first-page":"622","DOI":"10.1016\/j.neuroimage.2018.06.001","article-title":"The effect of machine learning regression algorithms and sample size on individualized behavioral prediction with functional connectivity features","volume":"178","author":"Cui","year":"2018","journal-title":"Neuroimage"},{"issue":"8","key":"10.1016\/j.bbih.2026.101299_bib35","doi-asserted-by":"crossref","first-page":"461","DOI":"10.1038\/s41575-019-0157-3","article-title":"The role of short-chain fatty acids in microbiota-gut-brain communication","volume":"16","author":"Dalile","year":"2019","journal-title":"Nat. Rev. Gastroenterol. Hepatol."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib36","doi-asserted-by":"crossref","first-page":"205","DOI":"10.1186\/s12859-022-04675-1","article-title":"Statistical power for cluster analysis","volume":"23","author":"Dalmaijer","year":"2022","journal-title":"BMC Bioinf."},{"key":"10.1016\/j.bbih.2026.101299_bib37","doi-asserted-by":"crossref","first-page":"415","DOI":"10.1016\/j.bbi.2023.07.023","article-title":"TSPO PET brain inflammation imaging: a transdiagnostic systematic review and meta-analysis of 156 case-control studies","volume":"113","author":"De Picker","year":"2023","journal-title":"Brain Behav. Immun."},{"issue":"5","key":"10.1016\/j.bbih.2026.101299_bib38","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1139\/jpn.0541","article-title":"The Montreal imaging stress task: using functional imaging to investigate the effects of perceiving and processing psychosocial stress in the human brain","volume":"30","author":"Dedovic","year":"2005","journal-title":"J. Psychiatry Neurosci."},{"issue":"18","key":"10.1016\/j.bbih.2026.101299_bib39","doi-asserted-by":"crossref","first-page":"1420","DOI":"10.1089\/ars.2020.8230","article-title":"Are circulating fibroblast growth factor 21 and N-Terminal prohormone of brain natriuretic peptide promising novel biomarkers in myalgic encephalomyelitis\/chronic fatigue syndrome?","volume":"34","author":"Domingo","year":"2021","journal-title":"Antioxid. Redox Signaling"},{"issue":"6","key":"10.1016\/j.bbih.2026.101299_bib40","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1053\/j.gastro.2016.03.035","article-title":"Rome IV-Functional GI disorders: disorders of gut-brain interaction","volume":"150","author":"Drossman","year":"2016","journal-title":"Gastroenterology"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib41","doi-asserted-by":"crossref","first-page":"268","DOI":"10.3390\/ijms27010268","article-title":"Insights into the complex biological network underlying myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"27","author":"Dudova","year":"2026","journal-title":"Int. J. Mol. Sci."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib43","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1038\/s41592-018-0235-4","article-title":"fMRIPrep: a robust preprocessing pipeline for functional MRI","volume":"16","author":"Esteban","year":"2019","journal-title":"Nat. Methods"},{"key":"10.1016\/j.bbih.2026.101299_bib42","article-title":"FMRIPrep (Version 20.2.6)","author":"Esteban","year":"2018","journal-title":"Zenodo"},{"key":"10.1016\/j.bbih.2026.101299_bib44","doi-asserted-by":"crossref","DOI":"10.3389\/fpsyg.2022.920556","article-title":"The link between energy-related sensations and metabolism: implications for treating fatigue","volume":"13","author":"Filippi","year":"2022","journal-title":"Front. Psychol."},{"issue":"10","key":"10.1016\/j.bbih.2026.101299_bib45","doi-asserted-by":"crossref","first-page":"2916","DOI":"10.1007\/s12671-025-02647-z","article-title":"Self-compassion, other-compassion, and subjective sleep quality indicators in a clinical population: an experience sampling study","volume":"16","author":"Fraser","year":"2025","journal-title":"Mindfulness"},{"key":"10.1016\/j.bbih.2026.101299_bib46","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1007\/BF01172967","article-title":"The dimensions of perfectionism","volume":"14","author":"Frost","year":"1990","journal-title":"Cognit. Ther. Res."},{"issue":"12","key":"10.1016\/j.bbih.2026.101299_bib47","doi-asserted-by":"crossref","first-page":"953","DOI":"10.7326\/0003-4819-121-12-199412150-00009","article-title":"The chronic fatigue syndrome: a comprehensive approach to its definition and study","volume":"121","author":"Fukuda","year":"1994","journal-title":"Ann. Intern. Med."},{"issue":"7","key":"10.1016\/j.bbih.2026.101299_bib48","doi-asserted-by":"crossref","first-page":"4204","DOI":"10.1093\/cercor\/bhaa048","article-title":"Multiple brain networks mediating stimulus-pain relationships in humans","volume":"30","author":"Geuter","year":"2020","journal-title":"Cerebr. Cortex"},{"issue":"10","key":"10.1016\/j.bbih.2026.101299_bib49","article-title":"Factors influencing the prognosis of patients with myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"12","author":"Ghali","year":"2022","journal-title":"Diagnostics (Basel)"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib51","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1186\/s12967-023-04179-3","article-title":"Proteomics and cytokine analyses distinguish myalgic encephalomyelitis\/chronic fatigue syndrome cases from controls","volume":"21","author":"Giloteaux","year":"2023","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib50","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1186\/s12967-020-02560-0","article-title":"Cytokine profiling of extracellular vesicles isolated from plasma in myalgic encephalomyelitis\/chronic fatigue syndrome: a pilot study","volume":"18","author":"Giloteaux","year":"2020","journal-title":"J. Transl. Med."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib52","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00213-021-05986-6","article-title":"Neurochemical abnormalities in chronic fatigue syndrome: a pilot magnetic resonance spectroscopy study at 7 tesla","volume":"239","author":"Godlewska","year":"2022","journal-title":"Psychopharmacology (Berl)"},{"key":"10.1016\/j.bbih.2026.101299_bib53","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1016\/j.bbi.2019.06.010","article-title":"Patients with fibromyalgia and chronic fatigue syndrome show increased hsCRP compared to healthy controls","volume":"81","author":"Groven","year":"2019","journal-title":"Brain Behav. Immun."},{"issue":"6","key":"10.1016\/j.bbih.2026.101299_bib54","doi-asserted-by":"crossref","first-page":"939","DOI":"10.1002\/ana.25731","article-title":"Extra-axial inflammatory signal in parameninges in migraine with visual aura","volume":"87","author":"Hadjikhani","year":"2020","journal-title":"Ann. Neurol."},{"key":"10.1016\/j.bbih.2026.101299_bib55","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.bbi.2013.06.010","article-title":"The neuroinflammation marker translocator protein is not elevated in individuals with mild-to-moderate depression: a [11C]PBR28 PET study","volume":"33","author":"Hannestad","year":"2013","journal-title":"Brain Behav. Immun."},{"key":"10.1016\/j.bbih.2026.101299_bib56","first-page":"88","article-title":"The decoding toolbox (TDT): a versatile software package for multivariate analyses of functional imaging data","volume":"8","author":"Hebart","year":"2014","journal-title":"Front. Neuroinf."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib57","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1186\/s12888-018-1983-5","article-title":"The dynamical signature of anhedonia in major depressive disorder: positive emotion dynamics, reactivity, and recovery","volume":"19","author":"Heininga","year":"2019","journal-title":"BMC Psychiatry"},{"issue":"12","key":"10.1016\/j.bbih.2026.101299_bib58","article-title":"Mapping the complexity of ME\/CFS: evidence for abnormal energy metabolism, altered immune profile, and vascular dysfunction","volume":"6","author":"Heng","year":"2025","journal-title":"Cell Rep. Med."},{"issue":"5","key":"10.1016\/j.bbih.2026.101299_bib59","doi-asserted-by":"crossref","first-page":"545","DOI":"10.1111\/j.1469-8986.1985.tb01649.x","article-title":"Individual differences in autonomic response: conditioned association or conditioned fear?","volume":"22","author":"Hodes","year":"1985","journal-title":"Psychophysiology"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib60","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.biopsych.2017.08.005","article-title":"Elevated translocator protein in anterior cingulate in major depression and a role for inflammation in suicidal thinking: a positron emission tomography study","volume":"83","author":"Holmes","year":"2018","journal-title":"Biol. Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib61","doi-asserted-by":"crossref","DOI":"10.1126\/sciadv.1400121","article-title":"Distinct plasma immune signatures in ME\/CFS are present early in the course of illness","volume":"1","author":"Hornig","year":"2015","journal-title":"Sci. Adv."},{"issue":"50","key":"10.1016\/j.bbih.2026.101299_bib62","doi-asserted-by":"crossref","DOI":"10.1073\/pnas.2415119121","article-title":"Transcriptional reprogramming primes CD8+ T cells toward exhaustion in Myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"121","author":"Iu","year":"2024","journal-title":"Proc. Natl. Acad. Sci. U. S. A"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib63","article-title":"[11C]-(R)-PK11195 positron emission tomography in patients with complex regional pain syndrome: a pilot study","volume":"96","author":"Jeon","year":"2017","journal-title":"Medicine (Baltim.)"},{"key":"10.1016\/j.bbih.2026.101299_bib64","doi-asserted-by":"crossref","DOI":"10.1016\/j.psyneuen.2019.104578","article-title":"The role of low-grade inflammation in ME\/CFS (Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome) - associations with symptoms","volume":"113","author":"Jonsj\u00f6","year":"2020","journal-title":"Psychoneuroendocrinology"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib65","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines10010034","article-title":"In vivo cerebral translocator protein (TSPO) binding and its relationship with blood adiponectin levels in treatment-na\u00efve young adults with major depression: a [(11)C]PK11195 PET study","volume":"10","author":"Joo","year":"2021","journal-title":"Biomedicines"},{"issue":"4","key":"10.1016\/j.bbih.2026.101299_bib66","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.3758\/s13428-011-0107-7","article-title":"ARTiiFACT: a tool for heart rate artifact processing and heart rate variability analysis","volume":"43","author":"Kaufmann","year":"2011","journal-title":"Behav. Res. Methods"},{"issue":"7","key":"10.1016\/j.bbih.2026.101299_bib67","doi-asserted-by":"crossref","first-page":"3771","DOI":"10.1007\/s12035-023-03784-z","article-title":"Dysregulation of the Kynurenine pathway, cytokine expression pattern, and proteomics profile link to symptomology in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"61","author":"Kavyani","year":"2024","journal-title":"Mol. Neurobiol."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib68","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1159\/000523975","article-title":"Basic concepts and hormonal regulators of the stress system","volume":"96","author":"Kazakou","year":"2023","journal-title":"Horm. Res. Paediatr."},{"issue":"6","key":"10.1016\/j.bbih.2026.101299_bib69","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jpsychores.2015.08.008","article-title":"Capturing the post-exertional exacerbation of fatigue following physical and cognitive challenge in patients with chronic fatigue syndrome","volume":"79","author":"Keech","year":"2015","journal-title":"J. Psychosom. Res."},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib70","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1016\/j.pscychresns.2015.10.014","article-title":"Altered resting-state functional connectivity in women with chronic fatigue syndrome","volume":"234","author":"Kim","year":"2015","journal-title":"Psychiatry Res."},{"issue":"13","key":"10.1016\/j.bbih.2026.101299_bib71","doi-asserted-by":"crossref","first-page":"2776","DOI":"10.1017\/S0033291720004894","article-title":"Modelling the temporal interplay between stress and affective disturbances in pathways to psychosis: an experience sampling study","volume":"52","author":"Klippel","year":"2022","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib72","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1016\/j.neuroimage.2015.06.059","article-title":"Psychosocial versus physiological stress - meta-analyses on deactivations and activations of the neural correlates of stress reactions","volume":"119","author":"Kogler","year":"2015","journal-title":"Neuroimage"},{"issue":"9","key":"10.1016\/j.bbih.2026.101299_bib73","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1046\/j.1525-1497.2001.016009606.x","article-title":"The PHQ-9: validity of a brief depression severity measure","volume":"16","author":"Kroenke","year":"2001","journal-title":"J. Gen. Intern. Med."},{"issue":"2","key":"10.1016\/j.bbih.2026.101299_bib74","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1097\/00006842-200203000-00008","article-title":"The PHQ-15: validity of a new measure for evaluating the severity of somatic symptoms","volume":"64","author":"Kroenke","year":"2002","journal-title":"Psychosom. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib75","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1016\/j.jneumeth.2015.02.021","article-title":"GraphVar: a user-friendly toolbox for comprehensive graph analyses of functional brain connectivity","volume":"245","author":"Kruschwitz","year":"2015","journal-title":"J. Neurosci. Methods"},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib76","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1017\/S0033291723003148","article-title":"Does the effect of cognitive behavior therapy for chronic fatigue syndrome (ME\/CFS) vary by patient characteristics? A systematic review and individual patient data meta-analysis","volume":"54","author":"Kuut","year":"2024","journal-title":"Psychol. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib77","series-title":"Technology in Mental Health Care Delivery Systems","first-page":"119","article-title":"Behavioral treatment and bio-behavioral assessment: computer applications","author":"Lang","year":"1980"},{"key":"10.1016\/j.bbih.2026.101299_bib78","series-title":"A Physiotherapist's Guide to Understanding and Managing ME\/CFS","author":"Leslie","year":"2023"},{"issue":"9","key":"10.1016\/j.bbih.2026.101299_bib79","doi-asserted-by":"crossref","first-page":"920","DOI":"10.3109\/00365529709011203","article-title":"Stool form scale as a useful guide to intestinal transit time","volume":"32","author":"Lewis","year":"1997","journal-title":"Scand. J. Gastroenterol."},{"key":"10.1016\/j.bbih.2026.101299_bib80","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1016\/j.jad.2018.08.021","article-title":"Microglial markers in the frontal cortex are related to cognitive dysfunctions in major depressive disorder","volume":"241","author":"Li","year":"2018","journal-title":"J. Affect. Disord."},{"key":"10.1016\/j.bbih.2026.101299_bib81","article-title":"Altered effective connectivity of resting-state networks by Tai chi chuan in chronic fatigue syndrome patients: a multivariate granger causality study","volume":"13","author":"Li","year":"2022","journal-title":"Front. Neurol."},{"issue":"Pt 3","key":"10.1016\/j.bbih.2026.101299_bib82","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1093\/brain\/awu377","article-title":"Evidence for brain glial activation in chronic pain patients","volume":"138","author":"Loggia","year":"2015","journal-title":"Brain"},{"key":"10.1016\/j.bbih.2026.101299_bib83","doi-asserted-by":"crossref","DOI":"10.3389\/fnins.2024.1395769","article-title":"A blood-free modeling approach for the quantification of the blood-to-brain tracer exchange in TSPO PET imaging","volume":"18","author":"Maccioni","year":"2024","journal-title":"Front. Neurosci."},{"key":"10.1016\/j.bbih.2026.101299_bib84","doi-asserted-by":"crossref","DOI":"10.7717\/peerj.13234","article-title":"The variability of emotions, physical complaints, intention, and self-efficacy: an ecological momentary assessment study in older adults","volume":"10","author":"Maes","year":"2022","journal-title":"PeerJ"},{"issue":"4","key":"10.1016\/j.bbih.2026.101299_bib85","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0232475","article-title":"A systematic review of neurological impairments in myalgic encephalomyelitis\/chronic fatigue syndrome using neuroimaging techniques","volume":"15","author":"Maksoud","year":"2020","journal-title":"PLoS One"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib86","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1186\/s12916-023-02893-9","article-title":"Biomarkers for myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS): a systematic review","volume":"21","author":"Maksoud","year":"2023","journal-title":"BMC Med."},{"key":"10.1016\/j.bbih.2026.101299_bib87","doi-asserted-by":"crossref","DOI":"10.1016\/j.jns.2021.117326","article-title":"Modulatory effects of cognitive exertion on regional functional connectivity of the salience network in women with ME\/CFS: a pilot study","volume":"422","author":"Manca","year":"2021","journal-title":"J. Neurol. Sci."},{"key":"10.1016\/j.bbih.2026.101299_bib88","article-title":"Fibromyalgia: when distress becomes (Un)sympathetic pain","volume":"2012","author":"Martinez-Lavin","year":"2012","journal-title":"Pain Res Treat."},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib89","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1097\/RHU.0000000000000089","article-title":"Sympathetic nervous system dysfunction in fibromyalgia, chronic fatigue syndrome, irritable bowel syndrome, and interstitial cystitis: a review of case-control studies","volume":"20","author":"Mart\u00ednez-Mart\u00ednez","year":"2014","journal-title":"J. Clin. Rheumatol."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib90","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1186\/s12888-019-2049-z","article-title":"Remote assessment of disease and relapse in major depressive disorder (RADAR-MDD): a multi-centre prospective cohort study protocol","volume":"19","author":"Matcham","year":"2019","journal-title":"BMC Psychiatry"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib91","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/s13550-020-00617-1","article-title":"Coexistence of cerebral hypometabolism and neuroinflammation in the thalamo-limbic-brainstem region in young women with functional somatic syndrome","volume":"10","author":"Matsudaira","year":"2020","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.bbih.2026.101299_bib92","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2019.109893","article-title":"Post-exertional malaise is associated with greater symptom burden and psychological distress in patients diagnosed with chronic fatigue syndrome","volume":"129","author":"May","year":"2020","journal-title":"J. Psychosom. Res."},{"issue":"15","key":"10.1016\/j.bbih.2026.101299_bib93","doi-asserted-by":"crossref","DOI":"10.3390\/ijms241511937","article-title":"Surveying the metabolic and dysfunctional profiles of T cells and NK cells in myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"24","author":"Maya","year":"2023","journal-title":"Int. J. Mol. Sci."},{"issue":"2","key":"10.1016\/j.bbih.2026.101299_bib94","doi-asserted-by":"crossref","first-page":"188","DOI":"10.1177\/1359105316664139","article-title":"Deconstructing post-exertional malaise: an exploratory factor analysis","volume":"24","author":"McManimen","year":"2019","journal-title":"J. Health Psychol."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib95","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1097\/HRP.0000000000000323","article-title":"The effects of peripheral inflammation on the Brain-A neuroimaging perspective","volume":"30","author":"Millett","year":"2022","journal-title":"Harv. Rev. Psychiatr."},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib96","doi-asserted-by":"crossref","first-page":"811","DOI":"10.3390\/jcm14030811","article-title":"Assessment of autonomic nervous system function in patients with chronic fatigue syndrome and Post-COVID-19 syndrome presenting with recurrent syncope","volume":"14","author":"Milovanovic","year":"2025","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib97","series-title":"Autonomic Nervous System Monitoring - Heart Rate Variability","article-title":"Root mean square of the successive differences as marker of the parasympathetic system and difference in the outcome after ANS stimulation","author":"Minarini","year":"2020"},{"issue":"34","key":"10.1016\/j.bbih.2026.101299_bib98","doi-asserted-by":"crossref","first-page":"E7150","DOI":"10.1073\/pnas.1710519114","article-title":"Cytokine signature associated with disease severity in chronic fatigue syndrome patients","volume":"114","author":"Montoya","year":"2017","journal-title":"Proc. Natl. Acad. Sci. U. S. A."},{"issue":"10","key":"10.1016\/j.bbih.2026.101299_bib99","doi-asserted-by":"crossref","first-page":"2015","DOI":"10.1017\/S0033291716000477","article-title":"Neural effects of social environmental stress - an activation likelihood estimation meta-analysis","volume":"46","author":"Mothersill","year":"2016","journal-title":"Psychol. Med."},{"issue":"2","key":"10.1016\/j.bbih.2026.101299_bib101","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1007\/s10072-021-05810-1","article-title":"Structural and functional connections between the autonomic nervous system, hypothalamic\u2013pituitary\u2013adrenal axis, and the immune system: a context and time dependent stress response network","volume":"43","author":"Mueller","year":"2022","journal-title":"Neurol. Sci."},{"issue":"10","key":"10.1016\/j.bbih.2026.101299_bib102","doi-asserted-by":"crossref","first-page":"2285","DOI":"10.1097\/j.pain.0000000000002927","article-title":"Evidence of neuroinflammation in fibromyalgia syndrome: a [ 18 F]DPA-714 positron emission tomography study","volume":"164","author":"Mueller","year":"2023","journal-title":"Pain"},{"issue":"2","key":"10.1016\/j.bbih.2026.101299_bib100","doi-asserted-by":"crossref","first-page":"562","DOI":"10.1007\/s11682-018-0029-4","article-title":"Evidence of widespread metabolite abnormalities in myalgic encephalomyelitis\/chronic fatigue syndrome: assessment with whole-brain magnetic resonance spectroscopy","volume":"14","author":"Mueller","year":"2020","journal-title":"Brain Imaging Behav."},{"issue":"2","key":"10.1016\/j.bbih.2026.101299_bib104","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1002\/wps.20513","article-title":"Experience sampling methodology in mental health research: new insights and technical developments","volume":"17","author":"Myin-Germeys","year":"2018","journal-title":"World Psychiatry"},{"key":"10.1016\/j.bbih.2026.101299_bib103","series-title":"Conducting, and Analyzing ESM Studies","article-title":"The open handbook of experience sampling methodology: a step-by-step guide to designing","author":"Myin-Germeys","year":"2026"},{"key":"10.1016\/j.bbih.2026.101299_bib105","doi-asserted-by":"crossref","first-page":"826","DOI":"10.3389\/fneur.2020.00826","article-title":"How myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) progresses: the natural history of ME\/CFS","volume":"11","author":"Nacul","year":"2020","journal-title":"Front. Neurol."},{"issue":"6","key":"10.1016\/j.bbih.2026.101299_bib106","doi-asserted-by":"crossref","first-page":"945","DOI":"10.2967\/jnumed.113.131045","article-title":"Neuroinflammation in patients with chronic fatigue syndrome\/myalgic encephalomyelitis: an (1)(1)C-(R)-PK11195 PET study","volume":"55","author":"Nakatomi","year":"2014","journal-title":"J. Nucl. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib107","doi-asserted-by":"crossref","DOI":"10.1016\/j.invent.2021.100395","article-title":"Internet and smartphone-based ecological momentary assessment and personalized advice (PROfeel) in adolescents with chronic conditions: a feasibility study","volume":"25","author":"Nap-van der Vlist","year":"2021","journal-title":"Internet Interventions"},{"key":"10.1016\/j.bbih.2026.101299_bib108","series-title":"Multidisciplinary Care: Myalgic Encephalomyelitis (Or Encephalopathy)\/Chronic Fatigue Syndrome: Diagnosis and Management","year":"2021"},{"key":"10.1016\/j.bbih.2026.101299_bib109","series-title":"Pharmacological Interventions. Myalgic Encephalomyelitis (Or Encephalopathy)\/Chronic Fatigue Syndrome: Diagnosis and Management","year":"2021"},{"issue":"43","key":"10.1016\/j.bbih.2026.101299_bib110","doi-asserted-by":"crossref","DOI":"10.1097\/MD.0000000000017600","article-title":"Evidence of altered cardiac autonomic regulation in myalgic encephalomyelitis\/chronic fatigue syndrome: a systematic review and meta-analysis","volume":"98","author":"Nelson","year":"2019","journal-title":"Medicine"},{"issue":"11","key":"10.1016\/j.bbih.2026.101299_bib112","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pcbi.1010634","article-title":"Brain-wide connectome inferences using functional connectivity MultiVariate pattern analyses (fc-MVPA)","volume":"18","author":"Nieto-Castanon","year":"2022","journal-title":"PLoS Comput. Biol."},{"key":"10.1016\/j.bbih.2026.101299_bib111","series-title":"CONN Functional Connectivity Toolbox: RRID:SCR_009550","first-page":"63","author":"Nieto-Castanon","year":"2022"},{"key":"10.1016\/j.bbih.2026.101299_bib113","series-title":"Somatoform Dissociation: Phenomena, Measurement, and Theoretical Issues","article-title":"Traumatic experiences checklist","author":"Nijenhuis","year":"1999"},{"key":"10.1016\/j.bbih.2026.101299_bib114","doi-asserted-by":"crossref","DOI":"10.1016\/j.jneumeth.2020.108827","article-title":"Osprey: open-source processing, reconstruction & estimation of magnetic resonance spectroscopy data","volume":"343","author":"Oeltzschner","year":"2020","journal-title":"J. Neurosci. Methods"},{"key":"10.1016\/j.bbih.2026.101299_bib115","series-title":"MINI-S Mini International Neuropsychiatric Interview-Simplified, Dutch Version 1.1 (DSM-5)","author":"Overbeek","year":"2019"},{"key":"10.1016\/j.bbih.2026.101299_bib116","series-title":"Statistical Parametric Mapping: the Analysis of Functional Brain Images","author":"Penny WF","year":"2011"},{"issue":"12","key":"10.1016\/j.bbih.2026.101299_bib117","doi-asserted-by":"crossref","DOI":"10.3390\/biomedicines13123001","article-title":"Comparable immune alterations and inflammatory signatures in ME\/CFS and long COVID","volume":"13","author":"Petrov","year":"2025","journal-title":"Biomedicines"},{"key":"10.1016\/j.bbih.2026.101299_bib118","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1016\/j.neubiorev.2021.11.020","article-title":"Brain activation elicited by acute stress: an ALE meta-analysis","volume":"132","author":"Qiu","year":"2022","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib119","doi-asserted-by":"crossref","DOI":"10.1212\/NXI.0000000000001113","article-title":"No signs of neuroinflammation in women with chronic fatigue syndrome or Q fever fatigue syndrome using the TSPO ligand [(11)C]-PK11195","volume":"9","author":"Raijmakers","year":"2022","journal-title":"Neurol. Neuroimmunol. Neuroinflamm."},{"key":"10.1016\/j.bbih.2026.101299_bib120","doi-asserted-by":"crossref","DOI":"10.1016\/j.bbi.2025.106098","article-title":"Killer cell immunoglobulin-like receptor (KIR) alleles suggested to be associated with myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"130","author":"Ramadan","year":"2025","journal-title":"Brain Behav. Immun."},{"issue":"2","key":"10.1016\/j.bbih.2026.101299_bib121","first-page":"201","article-title":"The Need for Controllability and Predictability questionnaire (NCP-q): psychometric properties and preliminary findings in a clinical sample","volume":"13","author":"Ramakers","year":"2025","journal-title":"Health Psychol. Rep."},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib122","article-title":"The bidirectional relationship between the gut microbiome and mental health: a comprehensive review","volume":"17","author":"Rathore","year":"2025","journal-title":"Cureus"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib123","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1186\/s13550-018-0401-9","article-title":"PET radioligand binding to translocator protein (TSPO) is increased in unmedicated depressed subjects","volume":"8","author":"Richards","year":"2018","journal-title":"EJNMMI Res."},{"key":"10.1016\/j.bbih.2026.101299_bib124","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.3389\/fimmu.2018.01028","article-title":"Association of T and NK cell phenotype with the diagnosis of Myalgic Encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"9","author":"Rivas","year":"2018","journal-title":"Front. Immunol."},{"issue":"8","key":"10.1016\/j.bbih.2026.101299_bib125","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1038\/s41592-025-02763-7","article-title":"MRIcroGL: voxel-based visualization for neuroimaging","volume":"22","author":"Rorden","year":"2025","journal-title":"Nat. Methods"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib126","doi-asserted-by":"crossref","first-page":"720","DOI":"10.1186\/s12967-023-04587-5","article-title":"A scoping review of 'Pacing' for management of Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome (ME\/CFS): lessons learned for the long COVID pandemic","volume":"21","author":"Sanal-Hayes","year":"2023","journal-title":"J. Transl. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib127","article-title":"Large-scale investigation confirms TRPM3 ion channel dysfunction in Myalgic Encephalomyelitis\/Chronic Fatigue Syndrome","volume":"12","author":"Sasso","year":"2025","journal-title":"Front Med (Lausanne)"},{"issue":"16","key":"10.1016\/j.bbih.2026.101299_bib128","doi-asserted-by":"crossref","DOI":"10.3390\/cancers13164198","article-title":"Neuroinflammation and its association with cognition, neuronal markers and peripheral inflammation after chemotherapy for breast cancer","volume":"13","author":"Schroyen","year":"2021","journal-title":"Cancers (Basel)"},{"issue":"4","key":"10.1016\/j.bbih.2026.101299_bib130","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1016\/S2215-0366(18)30048-8","article-title":"Association of translocator protein total distribution volume with duration of untreated major depressive disorder: a cross-sectional study","volume":"5","author":"Setiawan","year":"2018","journal-title":"Lancet Psychiatry"},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib129","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1001\/jamapsychiatry.2014.2427","article-title":"Role of translocator protein density, a marker of neuroinflammation, in the brain during major depressive episodes","volume":"72","author":"Setiawan","year":"2015","journal-title":"JAMA Psychiatry"},{"issue":"2","key":"10.1016\/j.bbih.2026.101299_bib131","doi-asserted-by":"crossref","first-page":"325","DOI":"10.3390\/jcm13020325","article-title":"Advancing research and treatment: an overview of clinical trials in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS) and future perspectives","volume":"13","author":"Seton","year":"2024","journal-title":"J. Clin. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib132","doi-asserted-by":"crossref","first-page":"258","DOI":"10.3389\/fpubh.2017.00258","article-title":"An overview of heart rate variability metrics and norms","volume":"5","author":"Shaffer","year":"2017","journal-title":"Front. Public Health"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib133","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1186\/s12967-020-02506-6","article-title":"Neuroimaging characteristics of myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS): a systematic review","volume":"18","author":"Shan","year":"2020","journal-title":"J. Transl. Med."},{"issue":"5","key":"10.1016\/j.bbih.2026.101299_bib134","doi-asserted-by":"crossref","DOI":"10.1002\/mco2.70168","article-title":"Gut microbiota dysbiosis: pathogenesis, diseases, prevention, and therapy","volume":"6","author":"Shen","year":"2025","journal-title":"MedComm"},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib135","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1556\/Mental.10.2009.3.5","article-title":"A questionnaire based study of subjective sleep quality: the psychometric evaluation of the Hungarian version of the Groningen sleep quality scale","volume":"10","author":"Simor","year":"2009","journal-title":"Ment\u00e1lhigi\u00e9n\u00e9 es Pszichoszomatika"},{"issue":"17","key":"10.1016\/j.bbih.2026.101299_bib136","doi-asserted-by":"crossref","first-page":"14412","DOI":"10.1021\/acsomega.2c00588","article-title":"The 18-kDa translocator protein PET tracers as a diagnostic marker for neuroinflammation: development and current standing","volume":"7","author":"Singh","year":"2022","journal-title":"ACS Omega"},{"issue":"12","key":"10.1016\/j.bbih.2026.101299_bib137","doi-asserted-by":"crossref","first-page":"1998","DOI":"10.1016\/j.psyneuen.2012.04.012","article-title":"Introducing the Maastricht Acute Stress Test (MAST): a quick and non-invasive approach to elicit robust autonomic and glucocorticoid stress responses","volume":"37","author":"Smeets","year":"2012","journal-title":"Psychoneuroendocrinology"},{"issue":"10","key":"10.1016\/j.bbih.2026.101299_bib138","doi-asserted-by":"crossref","first-page":"1092","DOI":"10.1001\/archinte.166.10.1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","journal-title":"Arch. Intern. Med."},{"key":"10.1016\/j.bbih.2026.101299_bib139","doi-asserted-by":"crossref","DOI":"10.3389\/fimmu.2024.1352744","article-title":"The gastrointestinal microbiota in the development of ME\/CFS: a critical view and potential perspectives","volume":"15","author":"Stallmach","year":"2024","journal-title":"Front. Immunol."},{"issue":"11","key":"10.1016\/j.bbih.2026.101299_bib140","doi-asserted-by":"crossref","DOI":"10.3390\/microorganisms8111715","article-title":"The influence of probiotics on the firmicutes\/bacteroidetes ratio in the treatment of obesity and inflammatory bowel disease","volume":"8","author":"Stojanov","year":"2020","journal-title":"Microorganisms"},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib141","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1111\/1467-9868.00346","article-title":"A direct approach to false discovery rates","volume":"64","author":"Storey","year":"2002","journal-title":"J. R. Stat. Soc., Ser. B Stat. Methodol."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib142","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1111\/j.1467-9868.2004.00439.x","article-title":"Strong control, conservative point estimation and simultaneous conservative consistency of false discovery rates: a unified approach","volume":"66","author":"Storey","year":"2003","journal-title":"J. R. Stat. Soc., Ser. B Stat. Methodol."},{"key":"10.1016\/j.bbih.2026.101299_bib143","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/j.neubiorev.2019.08.011","article-title":"Inflammatory proteins are altered in chronic fatigue syndrome-A systematic review and meta-analysis","volume":"107","author":"Strawbridge","year":"2019","journal-title":"Neurosci. Biobehav. Rev."},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib144","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1089\/brain.2022.0049","article-title":"Connectivity between salience and default mode networks and subcortical nodes distinguishes between two classes of myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"13","author":"Su","year":"2023","journal-title":"Brain Connect."},{"issue":"4","key":"10.1016\/j.bbih.2026.101299_bib145","first-page":"226","article-title":"Antibody-Dependent Cell-mediated Cytotoxicity (ADCC) in familial Myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS)","volume":"8","author":"Sung","year":"2020","journal-title":"Fatigue"},{"key":"10.1016\/j.bbih.2026.101299_bib146","series-title":"Recent Research in Myalgic encephalomyelitis\/chronic Fatigue Syndrome: an Evidence Map [Internet]","author":"Todhunter-Brown","year":"2025"},{"issue":"10","key":"10.1016\/j.bbih.2026.101299_bib147","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0186566","article-title":"Multiple co-clustering based on nonparametric mixture models with heterogeneous marginal distributions","volume":"12","author":"Tokuda","year":"2017","journal-title":"PLoS One"},{"issue":"4","key":"10.1016\/j.bbih.2026.101299_bib148","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1097\/j.pain.0000000000002108","article-title":"Thalamic neuroinflammation as a reproducible and discriminating signature for chronic low back pain","volume":"162","author":"Torrado-Carvajal","year":"2021","journal-title":"Pain"},{"key":"10.1016\/j.bbih.2026.101299_bib149","doi-asserted-by":"crossref","DOI":"10.1177\/13591053261420598","article-title":"Identifying post-exertional malaise subtypes: differentiating physical and mental PEM manifestations","author":"Tuzzolino","year":"2026","journal-title":"J. Health Psychol."},{"key":"10.1016\/j.bbih.2026.101299_bib150","series-title":"The Palgrave Handbook of Occupational Stress","first-page":"117","article-title":"Stress assessment in daily life using the experience sampling method","author":"Vaessen","year":"2023"},{"issue":"8","key":"10.1016\/j.bbih.2026.101299_bib151","doi-asserted-by":"crossref","first-page":"1735","DOI":"10.1017\/S0033291723003690","article-title":"Disentangling pain and fatigue in chronic fatigue syndrome: a resting state connectivity study before and after cognitive behavioral therapy","volume":"54","author":"van der Schaaf","year":"2024","journal-title":"Psychol. Med."},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib152","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1136\/gutjnl-2015-309618","article-title":"Stool consistency is strongly associated with gut microbiota richness and composition, enterotypes and bacterial growth rates","volume":"65","author":"Vandeputte","year":"2016","journal-title":"Gut"},{"key":"10.1016\/j.bbih.2026.101299_bib153","doi-asserted-by":"crossref","DOI":"10.1016\/j.jchromb.2024.124299","article-title":"The optimization and validation of a gas chromatography-mass spectrometry method to analyze the concentration of acetate, propionate and butyrate in human plasma or serum","volume":"1247","author":"Vandermeulen","year":"2024","journal-title":"J. Chromatogr., B: Anal. Technol. Biomed. Life Sci."},{"key":"10.1016\/j.bbih.2026.101299_bib154","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.3389\/fneur.2018.01033","article-title":"Neuroinflammation and cytokines in myalgic encephalomyelitis\/chronic fatigue syndrome (ME\/CFS): a critical review of research methods","volume":"9","author":"VanElzakker","year":"2018","journal-title":"Front. Neurol."},{"issue":"5","key":"10.1016\/j.bbih.2026.101299_bib155","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/0022-3999(94)90099-X","article-title":"Dimensional assessment of chronic fatigue syndrome","volume":"38","author":"Vercoulen","year":"1994","journal-title":"J. Psychosom. Res."},{"key":"10.1016\/j.bbih.2026.101299_bib156","doi-asserted-by":"crossref","DOI":"10.3389\/fphys.2023.1257557","article-title":"Post-exertional malaise in daily life and experimental exercise models in patients with myalgic encephalomyelitis\/chronic fatigue syndrome","volume":"14","author":"V\u00f8llestad","year":"2023","journal-title":"Front. Physiol."},{"key":"10.1016\/j.bbih.2026.101299_bib157","doi-asserted-by":"crossref","DOI":"10.2196\/39817","article-title":"Dynamic modelling of mental resilience in young adults: protocol for a longitudinal observational study (DynaM-OBS)","volume":"12","author":"Wackerhagen","year":"2023","journal-title":"JMIR Res. Protoc."},{"key":"10.1016\/j.bbih.2026.101299_bib158","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1016\/j.jneumeth.2018.07.001","article-title":"GraphVar 2.0: a user-friendly toolbox for machine learning on functional connectivity measures","volume":"308","author":"Waller","year":"2018","journal-title":"J. Neurosci. Methods"},{"issue":"1","key":"10.1016\/j.bbih.2026.101299_bib160","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1186\/s40001-024-01747-1","article-title":"Clinical evidence of the link between gut microbiome and myalgic encephalomyelitis\/chronic fatigue syndrome: a retrospective review","volume":"29","author":"Wang","year":"2024","journal-title":"Eur. J. Med. Res."},{"issue":"7","key":"10.1016\/j.bbih.2026.101299_bib159","doi-asserted-by":"crossref","first-page":"3576","DOI":"10.1109\/TCYB.2019.2950568","article-title":"Discovering multiple Co-Clusterings with matrix factorization","volume":"51","author":"Wang","year":"2019","journal-title":"IEEE Trans. Cybern."},{"key":"10.1016\/j.bbih.2026.101299_bib162","series-title":"SF-36 Health Survey Manual and Interpretation Guide","author":"Ware","year":"1993"},{"key":"10.1016\/j.bbih.2026.101299_bib161","series-title":"SF-36 Physical and Mental Health Summary Scales: a Users' Manual","author":"Ware","year":"1994"},{"issue":"6","key":"10.1016\/j.bbih.2026.101299_bib163","doi-asserted-by":"crossref","first-page":"1063","DOI":"10.1037\/0022-3514.54.6.1063","article-title":"Development and validation of brief measures of positive and negative affect: the PANAS scales","volume":"54","author":"Watson","year":"1988","journal-title":"J. Pers. Soc. Psychol."},{"issue":"3","key":"10.1016\/j.bbih.2026.101299_bib164","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1089\/brain.2012.0073","article-title":"Conn: a functional connectivity toolbox for correlated and anticorrelated brain networks","volume":"2","author":"Whitfield-Gabrieli","year":"2012","journal-title":"Brain Connect."},{"issue":"5","key":"10.1016\/j.bbih.2026.101299_bib165","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1002\/acr.20140","article-title":"The American College of Rheumatology preliminary diagnostic criteria for fibromyalgia and measurement of symptom severity","volume":"62","author":"Wolfe","year":"2010","journal-title":"Arthritis Care Res (Hoboken)"},{"key":"10.1016\/j.bbih.2026.101299_bib166","doi-asserted-by":"crossref","DOI":"10.1038\/s41380-026-03608-1","article-title":"Neuroendocrine signature of ME\/CFS: Meta-analytic evidence for bioactive cortisol deficit and exaggerated feedback sensitivity","author":"Woo","year":"2026","journal-title":"Mol. Psychiatr."},{"key":"10.1016\/j.bbih.2026.101299_bib167","doi-asserted-by":"crossref","DOI":"10.1016\/j.jpsychores.2020.110296","article-title":"Towards personalized assessment of fatigue perpetuating factors in patients with chronic fatigue syndrome using ecological momentary assessment: a pilot study","volume":"140","author":"Worm-Smeitink","year":"2021","journal-title":"J. Psychosom. Res."},{"issue":"7","key":"10.1016\/j.bbih.2026.101299_bib168","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0159351","article-title":"Aberrant resting-state functional connectivity in the salience network of Adolescent chronic fatigue syndrome","volume":"11","author":"Wortinger","year":"2016","journal-title":"PLoS One"},{"issue":"9","key":"10.1016\/j.bbih.2026.101299_bib169","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0184325","article-title":"Altered right anterior insular connectivity and loss of associated functions in adolescent chronic fatigue syndrome","volume":"12","author":"Wortinger","year":"2017","journal-title":"PLoS One"},{"issue":"5","key":"10.1016\/j.bbih.2026.101299_bib170","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1016\/j.physbeh.2007.07.001","article-title":"A real-time assessment of the effect of exercise in chronic fatigue syndrome","volume":"92","author":"Yoshiuchi","year":"2007","journal-title":"Physiol. Behav."}],"container-title":["Brain, Behavior, & Immunity - Health"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001328?httpAccept=text\/xml","content-type":"text\/xml","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/api.elsevier.com\/content\/article\/PII:S2666354626001328?httpAccept=text\/plain","content-type":"text\/plain","content-version":"vor","intended-application":"text-mining"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T20:19:17Z","timestamp":1789157957000},"score":1,"resource":{"primary":{"URL":"https:\/\/linkinghub.elsevier.com\/retrieve\/pii\/S2666354626001328"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10]]},"references-count":170,"alternative-id":["S2666354626001328"],"URL":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101299","relation":{},"ISSN":["2666-3546"],"issn-type":[{"value":"2666-3546","type":"print"}],"subject":[],"published":{"date-parts":[[2026,10]]},"assertion":[{"value":"Elsevier","name":"publisher","label":"This article is maintained by"},{"value":"Multimodal approach to identify neuropsychophysiological subgroups in myalgic encephalomyelitis\/chronic fatigue syndrome and their relevance for rehabilitation: protocol for a mechanistic cross-sectional and longitudinal study","name":"articletitle","label":"Article Title"},{"value":"Brain, Behavior, & Immunity - Health","name":"journaltitle","label":"Journal Title"},{"value":"https:\/\/doi.org\/10.1016\/j.bbih.2026.101299","name":"articlelink","label":"CrossRef DOI link to publisher maintained version"},{"value":"article","name":"content_type","label":"Content Type"},{"value":"\u00a9 2026 The Authors. Published by Elsevier Inc.","name":"copyright","label":"Copyright"}],"article-number":"101299"}}